The invention discloses a bionic heterogeneous
composite structure bone implant and a preparation method thereof, and relates to the technical field of medical implants.The bionic heterogeneous
composite structure bone implant comprises an inner-layer cross-shaped structure, a middle-layer negative Poisson's ratio structure and an outer-layer
honeycomb structure, and the cross-shaped structure, the negative Poisson's ratio structure and the
honeycomb structure jointly form a bionic
composite structure; and immersing the bionic composite structure subjected to double-network crosslinking into a
drug-containing solution for post-treatment and
drug loading to obtain the bionic heterogeneous composite structure. According to the invention, bionic
adaptation and intelligent optimization of mechanical properties are realized, and the
stress shielding problem is solved; according to the invention,
osseointegration and vascularization processes are obviously accelerated and enhanced, and leap-type improvement of
biological activity is realized; a novel intelligent treatment mode based on in-vivo microenvironment response is developed, and on-demand and accurate
drug delivery is achieved.