55 results about "Submucosa" patented technology

The invention provides a composition capable of penetrating an intestinal barrier by oral administration. The composition contains a carrier or an auxiliary material of a targeted Microflod cell Dectin-1 receptor, and one or / and a plurality of medicinal components / components, wherein the carrier or the auxiliary material of the target Microflood cell Dectin-1 receptor is beta-glucan, and the carrier or the auxiliary material of the target Microflood cell Dectin-1 receptor is beta-glucan. The effective components / components are traditional Chinese medicine effective components / components, or / and probiotics, or / and chemical medicine components, or / and biological medicines. The invention relates to a composition capable of realizing oral administration and penetrating through an intestinal barrier, which is based on the discovery of the inventor that the composition reaches colon through gastrointestinal tracts, targets colon Microflood cells, is taken by the Microflood cells, penetrates through the intestinal barrier and enters immune tissue Colonic Patches of a colon submucosa. Based on the research, the composition disclosed by the invention can be used for treating various diseases, such as ulcerative colitis, Crohn's disease, colon cancer, rheumatoid arthritis or bacterial pneumonia after being orally taken and absorbed by rectum.

The invention belongs to the technical field of medical equipment. The endoscopic surgery operation quality real-time quantitative evaluation system comprises an endoscopic camera probe used for collecting endoscopic images and an endoscopic handle used for operation. The displacement sensor is integrated on the endoscope camera probe and is used for detecting the endoscope entering speed; the pressure sensor is integrated on the gas injection pipeline and is used for detecting the intracavity pressure; the force sensor is integrated on the endoscope handle and is used for detecting the tissue traction deformation; the optical coherence layer scanning probe is integrated on the endoscope camera probe and used for detecting the thickness of the submucous membrane, and the processing terminal is used for conducting real-time quantitative evaluation on the endoscopic surgery operation quality according to the endoscope entering speed, the intracavity pressure, the thickness of the submucous membrane, the tissue traction deformation image, the included angle between an instrument and a focus normal and the complication response time. According to the invention, full-process datamation real-time accurate evaluation of operation skills and operation safety of operators is realized.

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and / or other pulmonary diseases or disorders.

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, those within the respiratory tract, particularly the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The systems may be used to treat pathogens, such as bacteria and viruses, particularly coronaviruses.

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and / or other pulmonary diseases or disorders.

The invention discloses a submucous membrane multi-point thickness measuring method for endoscopic submucous membrane dissection. The submucous membrane multi-point thickness measuring method comprises the following steps that images are collected, wherein pathological images cut by the endoscopic submucous membrane dissection are obtained; image preprocessing: improving the brightness of the pathological image and the contrast ratio of a bright part, and smoothing the pathological image through Gaussian filtering; image feature extraction: extracting texture features of the pathological image, using a local binary pattern (LBP) algorithm, and generating a vertical coordinate feature map with the same size as the pathological image; feature fusion: superposing the preprocessed noise reduction image, the texture feature image and the ordinate feature map; submucous membrane pathological tissue segmentation: using a UNet neural network to carry out image segmentation task training on the superimposed image; calculating the thickness of multiple points; and quality evaluation. According to the method, the thickness of the submucous membrane is measured through the pathological tissue image, and ESD effect judgment and operation quality control are facilitated.

Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of an organ of a subject, wherein the organ is not the esophagus. In some embodiments, the organ is in the gastrointestinal tract. These methods include injecting submucosally into the organ of the subject a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel to form a cushion between the submucosa and the underlying muscularis propria at the region of the organ, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 30 minutes at a temperature of about 37° C.; b) a flow viscosity suitable for infusion into the organ; and c) a stiffness of about 10 to about 400 Pascal (Pa).

Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and / or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition.

The present invention relates to an artificial digestive tract tissue for training in endoscopic submucosal dissection (ESD) and a method for manufacturing the same. Specifically, the invention relates to an artificial digestive tract tissue configured to mimic the mucosal layer, submucosal layer, and muscle layer constituting the human digestive tract tissue in a multilayer structure, such that swelling occurs upon liquid injection and a color change occurs due to changes in salt concentration, and to a casting and curing-based hydrogel molding process for manufacturing the same. According to the present invention, the problems associated with existing animal tissue-based ESD training simulators can be resolved, repeated use is possible, and training tailored to the structural characteristics of specific organs (stomach, large intestine, small intestine, etc.) is possible.

Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of an organ of a subject, wherein the organ is not the esophagus. In some embodiments, the organ is in the gastrointestinal tract. These methods include injecting submucosally into the organ of the subject a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel to form a cushion between the submucosa and the underlying muscularis propria at the region of the organ, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 30 minutes at a temperature of about 37° C.; b) a flow viscosity suitable for infusion into the organ; and c) a stiffness of about 10 to about 400 Pascal (Pa).

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and / or other pulmonary diseases or disorders.

An endoscope apparatus includes a processor. An image signal includes a first image signal corresponding to first light and a second image signal corresponding to second light. The processor determines at least one of whether or not a submucosa region or a bleeding region is included in an image based on the image signal. In a case where the submucosa region is included, the processor performs conversion processing that increases a combination ratio of the second image signal to the first image signal in an image region including the submucosa region, and allocates a combined image signal to a G-channel. In a case where the bleeding region is included, the processor performs conversion processing that increases a combination ratio of the first image signal to the second image signal in an image region including the bleeding region, and allocates the combined image signal to the G-channel.

The utility model relates to the technical field of medical balloons, in particular to a balloon device which comprises a catheter seat, a flexible catheter, a fixing ring and a balloon. One end of the flexible catheter is communicated with the catheter seat, the other end of the flexible catheter is fixedly connected with the fixing ring, the balloon is arranged on the side, away from the flexible catheter, of the fixing ring, and the flexible catheter is communicated with the balloon through a through hole in the fixing ring. Part of the balloon is attached to the circumferential contour of the fixing ring to form a connecting part, the balloon is fixedly connected with the fixing ring through the connecting part, and the balloon forms an expanding structure extending in the axial direction of the fixing ring after being expanded. In order to solve the technical problem that an existing ESD operation has defects, according to the balloon device, a catheter base is communicated with an external gas-liquid source, gas or liquid can be injected into a balloon through the catheter base so that the balloon can be filled, the filled balloon can eject pathological upper-layer mucous membrane tissue open, the lower layer of the mucous membrane can be exposed, and therefore the balloon device can be used for protecting the upper layer of the mucous membrane. Therefore, a doctor can conveniently perform stripping.

Disclosed in the present disclosure are a chitosan-based temperature-sensitive endoscopic submucosal injection, and a preparation method therefor and use thereof. The injection comprises chitosan suitable for conventional pH value, polyvinylpyrrolidone, sodium β-glycerophosphate, and sodium bicarbonate. The injection has good low-temperature stability and high injectability, and can be injected by means of utilizing a conventional endoscopic injection needle currently in clinical use. Meanwhile, after being injected into the submucosa, the injection can rapidly form a hydrogel with relatively high mechanical strength higher-strength hydrogel under the action of body temperature, and exhibits higher tissue adhesion, which enables more stable support for the elevated state of the mucosal layer, thereby delaying the height decrease, better facilitating ESD operation, and reducing the occurrence probability of complications. Therefore, the injection holds significant practical value in clinical applications.

The invention relates to the field of allergic rhinitis, and discloses an application of sodium hyaluronate in preparation of an external medicine for treating allergic rhinitis. Based on actual clinical efficacy verification, the mechanism of sodium hyaluronate playing efficacy is that sodium hyaluronate can be used for preparing an external medicine for treating allergic rhinitis; sodium hyaluronate is used for reducing drainage lymph nodes in an atopic individual area and generating specificity I gE by nasal submucosa plasma cells, blocking contact between allergens and the surface specificity I gE of sensitized mast cells or sensitized basophilic granulocytes in a sensitized body, stopping development of anaphylaxis and promoting subduing of nasal mucosa inflammation, so that allergy symptoms are eliminated, and the nasal mucosa inflammation eliminating effect is achieved. According to the embodiment of the invention, the result of treating AR by adopting HA nasal drops shows that an obvious effect is achieved 1-2 days after the medicine is taken, the medicine takes effect quickly, the safety is relatively high, and the medicine can be used as a new product for industrial reproducible production.

The present invention provides a method for preparing a mouse intestinal tissue wax block for slicing, which comprises the following steps: sampling of intestinal tissue, fixation of intestinal tissue, dehydration of intestinal tissue, and embedding of intestinal tissue. The present invention has simple steps and convenient operation. The embedded intestinal tissue wax block can keep the intestinal tissue morphology intact during subsequent slicing, without or only occasionally showing muscle layer separation phenomenon; the connective tissue morphology of the submucosal layer is completely presented, which is convenient for scientific researchers to conduct comprehensive observation of specimens, and provides reliable materials for theoretical research on intestinal diseases.

Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and / or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Ingestible devices can deliver therapeutic agents directly to desired tissues of a subject's GI tract, such as the submucosa, mucosa, and / or mucus layer of the GI tract, and methods of using the same. Ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The present disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

A new method is provided that precisely harmonizes the structural and functional biological processes that lead to the optimal reconstruction of ocular surface disorders. The method consists of the administration of a trilaminar (3D) material, which comprises the mucosa, the basement membrane, and the submucosa of the porcine esophagus in a stabilized conformation of integrated layers, which accurately imitates ocular structures, whose mechanical properties, biocompatibility, and integration into the host's tissues, facilitate the structural and functional restoration of lost or damaged ocular tissues. Through the mimesis of the spatial microenvironments generated by their structure and their functional conjugation with the signals of the host's extracellular matrix, the reconstruction of the neo-tissue is successfully guided.

The present invention relates to ingestible devices for delivery of therapeutic agents to the gastrointestinal tract. The ingestible device may deliver a therapeutic agent directly to a desired tissue of the GI tract of a subject, such as a submucosal, mucosal, and / or mucous layer of the GI tract, and methods of using the same. The ingestible device can deliver the therapeutic agent in a safe, efficient and reliable manner. The disclosure also provides a pharmaceutical composition for use in a method of treating a disease or condition in a subject in need thereof.

The invention provides a sodium ion-sensitive digestive tract submucosa injection filler and application thereof. The filler comprises a calcium ion complexing cosolvent, gellan gum, a thickening agent, an osmotic pressure regulator and a pH regulator. By utilizing the characteristic that gellan gum and sodium ions are combined to form gel, the tissue filling material is prepared, the tissue filling material reacts with sodium ions in tissue fluid to form gel after being injected into human tissues, the effects of filling and forming bulges are achieved, and auxiliary substances are specifically added to form a stable and effective filling agent without damage to the body.

This application discloses a multi-point submucosal thickness measurement method for endoscopic submucosal dissection (ESD). The method comprises the following steps: image acquisition: obtaining a pathological image obtained by endoscopic submucosal dissection; image preprocessing: enhancing the brightness and highlight contrast of the pathological image and smoothing the pathological image using Gaussian filtering; image feature extraction: extracting texture features from the pathological image using the local binary pattern (LBP) algorithm and generating a vertical coordinate feature map of the same size as the pathological image; feature fusion: superimposing the denoised image, texture feature image, and vertical coordinate feature map obtained from the preprocessing; submucosal pathological tissue segmentation: training the superimposed image using a UNet neural network for image segmentation; multi-point thickness calculation; and quality assessment. This application measures submucosal thickness using pathological tissue images, facilitating the assessment of ESD efficacy and surgical quality control.

The invention discloses a colorectal polyp scanning system based on a two-photon microscopic imaging system (second harmonic). The colorectal polyp scanning system comprises a two-photon laser microscope system and a data processing system, the two-photon laser microscope system is used for scanning a polyp slice sample and generating a second harmonic (SHG) image; and the data processing system is used for analyzing the SHG image and extracting collagen related information displayed in the SHG image. According to the colorectal polyp scanning system based on the SHG image, marking is not needed, the canceration risk of polyp can be effectively evaluated by detecting the collagen density and distribution of the intrinsic layer and the submucosa of the mucosa in the polyp sample, a scientific basis is provided for early screening of cancer, and the accuracy and convenience of an existing detection means are improved.

To provide methods for dissecting a mucosa and a submucosa from a muscularis propria from a region of an organ of a subject.SOLUTION: Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of an organ of a subject, wherein the organ is not the esophagus. In some embodiments, the organ is in the gastrointestinal tract. These methods include injecting submucosally into the organ of the subject a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel to form a cushion between the submucosa and the underlying muscularis propria at the region of the organ, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 30 minutes at a temperature of about 37°C; b) a flow viscosity suitable for infusion into the organ; and c) a stiffness of about 10 to about 400 Pascal (Pa).SELECTED DRAWING: None

A method for preparing a thermosensitive submucosal injection for endoscopic submucosal dissection (ESD), relating to the technical field of regenerative medicine. The specific method involves constructing a novel thermosensitive submucosal injection solution capable of sustained-release hemostatic drugs and growth factors using high-pH chitosan, polyvinylpyrrolidone, calcium ions, and disodium β-glycerophosphate. This injection has very low viscosity, does not require special injection devices, is able to be injected using conventional endoscopic injection needles currently used in clinical practice, and exhibits high injection rate. Additionally, after being injected into the submucosal layer, this injection rapidly forms a high-strength hydrogel under body temperature, more stably supporting the raised state of the mucosal layer to facilitate ESD operations. It also reduces intraoperative and postoperative bleeding, promotes postoperative wound healing, and holds significant clinical practical application value.

The invention discloses a visual intracavitary microneedle injection device in the field of medical cosmetology instruments, which comprises a controller and a support part, and one end of the support part is detachably connected with a distraction part; a medicine container needle cylinder is detachably connected into the opening part, scale marks are carved on the surface of the needle cylinder, and a driving assembly used for driving the medicine container needle cylinder to convey medicine and rotate by 360 degrees is arranged in the supporting part. The end, away from the supporting part, of the distraction part is rotationally matched with a connecting ring. By means of an automatic rotary injection mode, 360-degree rotation is gradually carried out in the vagina, uniform rotary injection of medicine is achieved, manual angle adjustment is not needed, in the injection process, the microneedle penetrates through the vaginal mucosa to carry out visual injection, the medicine is accurately sent to the submucosa, medicine absorption is facilitated, the treatment effect is achieved, pain and discomfort of a patient can be reduced, and the application range is wide. Visual injection facilitates big data and AI evaluation on the injection effect, so that a personalized treatment scheme is formulated; meanwhile, the device is easy and convenient to operate and suitable for clinical application and popularization.

The aim of the invention is to provide a traction device for sufficiently exposing the submucosa so as to provide suitable conditions for the dissection device to move freely throughout the entire dissection of the tumoral mucosa. The traction device (1) of the invention is characterised in that it comprises a proximal anchor (3) that is mounted so as to move relative to an elastic member (2) between a minimum proximal distance and a maximum proximal distance, and in that the traction device comprises an adjustment member (6) configured to adjust the maximum proximal distance between the initial maximum proximal distance and a final maximum proximal distance smaller than the initial maximum proximal distance.

The invention discloses an absorbable anti-inflammatory catgut suture and a manufacturing method thereof, and belongs to the technical field of biomedical materials. The catgut suture is prepared from a catgut submucous membrane as a raw material through the steps of cleaning and bulking, degreasing, submucous membrane stripping, decellularization treatment, winding, dehydration and shaping and the like. An enzyme treatment step is introduced in a decellularization treatment stage, so that the immunogenicity of the material is remarkably reduced, and the catgut is endowed with an active anti-inflammatory characteristic. The catgut suture prepared by the method is few in cell residue, complete in collagen structure, appropriate in mechanical strength, light in inflammatory response after being implanted in vivo, high in wound healing speed, excellent in biocompatibility and suitable for various surgical suturing.

The present invention relates to the technical field of image processing, and specifically relates to a redness differentiation calibration (RDC) method for a medical image, the method comprising the following steps: acquiring an original image, and obtaining values L, a and b of the original image; performing redness intensity estimation on the original image by means of the values a and b; performing edge information extraction on the original image by means of the value L; calibrating the original image by means of calculation, so as to obtain a calibration result LQ; and using the obtained LQ and the obtained values a and b to convert a CIELAB color space of the original image into an RGB color space, and outputting a result image. Compared with a conventional method, the present technical solution can effectively estimate the redness intensity, calibrates a mucosal structure and tissue features, and highlights microvessels in a superficial mucosa and a submucosa in an endoscope image; moreover, transformation on a non-red area is less, such that a processed image is more suitable for a doctor to observe and make a diagnosis.

Disclosed is a cryogenic catheter including a probe at the distal end, a shaft at the proximal end, and a cryogenic fluid delivery channel assembly operably coupled to the probe and shaft. The cryogenic fluid delivery channel assembly includes a cryogenic sprayer component, a catheter support wire, and a catheter overtube. The cryogenic sprayer component includes at least one sprayer tube and at least one delivery channel. The sprayer tubes include at least one sprayer through which a cryogenic fluid transported within the at least one delivery channel can be delivered to one or more target areas or treatment zones. The cryogenic fluid delivery channel assembly does not require the use of a central rail. The cryogenic catheter can be used in cryogenic ablation systems and methods involving cryogenic ablation of mucosal tissue and / or of both mucosal tissue and submucosal tissue in the gastrointestinal tract of a subject.