22 results about "Submucosa" patented technology

The present invention relates to an artificial digestive tract tissue for training in endoscopic submucosal dissection (ESD) and a method for manufacturing the same. Specifically, the invention relates to an artificial digestive tract tissue configured to mimic the mucosal layer, submucosal layer, and muscle layer constituting the human digestive tract tissue in a multilayer structure, such that swelling occurs upon liquid injection and a color change occurs due to changes in salt concentration, and to a casting and curing-based hydrogel molding process for manufacturing the same. According to the present invention, the problems associated with existing animal tissue-based ESD training simulators can be resolved, repeated use is possible, and training tailored to the structural characteristics of specific organs (stomach, large intestine, small intestine, etc.) is possible.

Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of an organ of a subject, wherein the organ is not the esophagus. In some embodiments, the organ is in the gastrointestinal tract. These methods include injecting submucosally into the organ of the subject a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel to form a cushion between the submucosa and the underlying muscularis propria at the region of the organ, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 30 minutes at a temperature of about 37° C.; b) a flow viscosity suitable for infusion into the organ; and c) a stiffness of about 10 to about 400 Pascal (Pa).

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and / or other pulmonary diseases or disorders.

Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and / or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

The invention provides a sodium ion-sensitive digestive tract submucosa injection filler and application thereof. The filler comprises a calcium ion complexing cosolvent, gellan gum, a thickening agent, an osmotic pressure regulator and a pH regulator. By utilizing the characteristic that gellan gum and sodium ions are combined to form gel, the tissue filling material is prepared, the tissue filling material reacts with sodium ions in tissue fluid to form gel after being injected into human tissues, the effects of filling and forming bulges are achieved, and auxiliary substances are specifically added to form a stable and effective filling agent without damage to the body.

The invention discloses an absorbable anti-inflammatory catgut suture and a manufacturing method thereof, and belongs to the technical field of biomedical materials. The catgut suture is prepared from a catgut submucous membrane as a raw material through the steps of cleaning and bulking, degreasing, submucous membrane stripping, decellularization treatment, winding, dehydration and shaping and the like. An enzyme treatment step is introduced in a decellularization treatment stage, so that the immunogenicity of the material is remarkably reduced, and the catgut is endowed with an active anti-inflammatory characteristic. The catgut suture prepared by the method is few in cell residue, complete in collagen structure, appropriate in mechanical strength, light in inflammatory response after being implanted in vivo, high in wound healing speed, excellent in biocompatibility and suitable for various surgical suturing.

An endoscopic tool for facilitating injection of fluid into a tissue submucosa includes a first cannula, a suction source, a fluid lumen, and a second cannula. The first cannula has a suction surface disposed at a distal end and defines a suction lumen. The suction source is coupled to the first cannula and generates a negative pressure within the suction lumen. The second cannula is disposed in a fluid lumen separate from the aspiration lumen, is adapted to be coupled to a fluid source, and carries a needle at a distal end thereof. The tool draws the mucosal layer via aspiration, which expands the submucosal layer and injects fluid via the needle to the expanded portion of the submucosal layer, resulting in an elevated tissue portion around the injection site.

Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and / or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

The application discloses absorbable anti-inflammatory catgut and a manufacturing method thereof, and belongs to the technical field of biomedical materials. The catgut is prepared from a sheep intestinal submucosa, and is prepared through the steps of cleaning and swelling, degreasing, submucosa stripping, decellularization, winding and dehydration shaping. An enzyme treatment step is introduced in the decellularization step, which significantly reduces the immunogenicity of the material and endows the catgut with active anti-inflammatory properties. The catgut prepared by the method has less cell residues, complete collagen structure, appropriate mechanical strength, slight inflammatory reaction after being implanted into a body, fast wound healing speed and excellent biocompatibility, and is suitable for suture of various surgical operations.

The application provides a polyurethane / small intestinal submucosa composite material and a preparation method and application thereof, and belongs to the field of medicines. The polyurethane / small intestinal submucosa composite material with an asymmetric structure is prepared by using a freeze-drying and impregnation drying method and different structural forms of the same components. The composite material is porous sponge on one side and dense film on the other side, can effectively prevent leakage on the basis of guaranteeing mechanical properties, and performs full-layer repair. The composite material can adjust the component ratio according to different requirements, and then adjust the mechanical properties, so as to match the normal bladder mechanical behavior of different species. The preparation method of the composite material is simple and convenient, has high popularization, can be popularized to other polyurethane / extracellular matrix materials, and has a good application prospect.

Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of the esophagus of a subject. These methods include injecting submucosally into the region of the esophagus of the subject a pharmaceutical composition comprising a urinary bladder extracellular matrix (ECM) hydrogel, to form a cushion between the submucosa and the underlying muscularis propria at the region of the esophagus, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 20 minutes at a temperature of about 37° C.; b) a flow viscosity suitable for infusion into the esophagus; and c) a stiffness of about 10 to about 400 Pascal (Pa).

Disclosed is a cryogenic catheter probe, cryogenic ablation system, and use thereof for performing cryogenic ablation of mucosal tissue and / or of both mucosal tissue and submucosal tissue in the gastrointestinal tract of a subject. The cryogenic catheter probe includes a chamber and a channel assembly housed within the chamber. The channel assembly includes a central rail, at least one cryogenic fluid delivery channel, a delivery channel guide, and a sprayer guide. The at least one cryogenic fluid delivery channel has a fluid delivery channel portion and a sprayer connected to the fluid delivery channel portion, and is mounted on the central rail for longitudinal movement along the central rail. The sprayer is configured to release cryogenic spray in at least one treatment zone along the hollow body portion of the chamber.

The utility model relates to the technical field of submucosal injection needles, and discloses a submucosal injection needle for a disposable endoscope, which comprises a handle, an infusion tube is fixedly connected inside the handle, one end of the infusion tube is fixedly connected with an end head, the inner wall of the handle is slidably connected with an infusion push tube, and the end head is fixedly connected with an end head. The end of the infusion tube is fixedly connected to the interior of the infusion push tube, a telescopic hose is arranged in the middle of the infusion tube, a clamping assembly is arranged in the infusion push tube and used for fixing the infusion push tube, and a needle is fixedly connected to one end of the infusion push tube. According to the utility model, the problem that the injection needle is difficult to adapt to diversified clinical requirements due to difficulty in multi-section adjustment according to different mucous membrane thicknesses and operation requirements is solved, and the purposes of accurately controlling the extension length of the needle head according to the mucous membrane thickness and the specific lesion position and ensuring that the needle head accurately pierces into the submucous membrane are achieved.

The invention belongs to the technical field of medical apparatuses and instruments, and discloses a digestive endoscope traction and lifting auxiliary instrument. A traction and lifting assembly of the digestive endoscope traction and lifting auxiliary instrument comprises a clamping assembly and a continuum assembly, an opening and closing push-pull wire of the clamping assembly is in transmission connection with a clamp assembly, and the clamp assembly can be opened or closed by pushing and pulling the opening and closing push-pull wire; the continuum assembly comprises a tubular continuum, a first drawing wire, a second drawing wire, a third drawing wire and a fourth drawing wire, the opening and closing push-pull wire is arranged in the tubular continuum in a penetrating mode, the tubular continuum can be bent up and down by pulling the tail ends of the first drawing wire and the second drawing wire, and the tubular continuum can be bent left and right by pulling the tail ends of the third drawing wire and the fourth drawing wire. According to the invention, tissues can be drawn simultaneously, the submucosa can be exposed, and the operation field can be expanded.

A multifunctional biological plugging pad for a liver section belongs to the field of medical instruments. Aiming at the problems of section bleeding, bile leakage and tissue healing after the hepatic resection, the invention provides the multi-layer composite biological plugging pad. The upper layer is an oxidized regenerated cellulose hemostatic layer with the thickness of 1-2mm; the middle layer is a cross-linked polyacrylate and chitosan composite expansion sealing layer and expands when meeting body fluid to form physical plugging; the lower layer is a decellularized small intestinal submucosa regeneration promoting layer which can promote tissue regeneration; and the bottom surface is coated with an NHS activated polyethylene glycol adhesive layer with the thickness of 10-50 microns. The diameter of the product is 3-15cm, the total thickness is 2-5mm, and the material can be degraded and absorbed in vivo. The device is suitable for the hepatobiliary surgery, the pancreatic surgery and other parenchyma visceral organ resection surgery, operation can be simplified, complications are reduced, and postoperative rehabilitation is promoted.

A stent scaffold combined with amniotic tissue provides for a biocompatible stent that has improved biocompatibility and hemocompatibility. The amnion tissue can be variously modified or unmodified form of amnion tissue such as non-cryo amnion tissue, solubilized amnion tissue, amnion tissue fabric, chemically modified amnion tissue, amnion tissue treated with radiation, amnion tissue treated with heat, or a combination thereof. Materials such as polymer, placental tissue, pericardium tissue, small intestine submucosa can be used in combination with the amnion tissue. The amnion tissue can be attached to the inside, the outside, both inside and outside, or complete encapsulation of the stent scaffold. In some embodiments, at least part of the covering or lining comprises a plurality of layers of amnion tissue. The method of making the biocompatible stent and its delivery and deployment are also discussed.

In endoscopic submucosal dissection, the blood vessels contained within the submucosa are visualized. [Solution] An information processing device according to one embodiment of the present invention includes a highlighting unit that highlights the region of blood vessels contained in the submucosa in the image of an endoscopic system used in endoscopic submucosal dissection for early gastrointestinal malignant tumors.

The invention relates to the technical field of biomedical materials, discloses a preparation method of a bone repair mineralized biological membrane capable of inducing gene expression and a product, and aims at solving the problems that an existing bone repair material HAP crystal is difficult to regulate and control, the mechanical activity and the biological activity are not matched, bone induction is weak, the process is complex and the like. The preparation method comprises the following steps: S1, preparing a decellularized small intestinal submucosa (SIS) membrane and sterilizing; s2, constructing a pDA-PAM (at) SIS composite membrane; s3, inducing directional growth of HAP through ion permeation biomimetic mineralization; and S4, cleaning and drying to obtain the HAP / SIS collagen mineralized biological membrane. The product contains an SIS collagen matrix and low-crystallinity nano HAP (the width is 4-20nm, the length is 31-105nm, and the product is oriented along a c axis), the tensile strength is greater than or equal to 13MPa, the elastic modulus is greater than or equal to 75MPa, the specific surface area is greater than or equal to 60m < 2 > / g, and osteogenic genes such as ALP, Runx2 and the like can be up-regulated by more than or equal to 2 times. The method is mild in process, easy to operate, good in biocompatibility, high in bone conduction and inductivity, suitable for large-scale production and capable of meeting the clinical bone defect repair requirement.

The invention provides a tubular water-cooled radiofrequency ablation electrode. The tubular water-cooled radiofrequency ablation electrode comprises an ablation working section, a radiofrequency unit and a cooling unit, the ablation working section comprises an ablation catheter base handle, a radiofrequency ablation electrode and an insulating blunt end which are connected in sequence, the radiofrequency ablation electrode is of a hollow tubular structure, the tube wall of the radiofrequency ablation electrode forms a radiofrequency emitting surface, and the top end of the radiofrequency ablation electrode is fixedly connected with the insulating blunt end in a sealed mode; the radio frequency unit comprises an electric radio frequency transmitter, an electrode inner temperature thermocouple, an electrode wire, an electrode connecting wire and a dispersed electrode plate. And the cooling unit is a circulating water cooling unit. The device is matched with a minimally invasive surgery, a laparoscope or a rectoscope, a bladder admission passage and a transurethral superior orifice, minimally invasive precise ablation of hyperplasia prostate tissue is achieved, and meanwhile urethral mucosa, submucosa and sphincter inside and outside the urethra are effectively protected. The device is particularly suitable for treating prostatic hyperplasia protruding into the bladder and has the advantages of being accurate in treatment, easy and convenient to operate, rapid in recovery and the like.

This invention discloses a cross-suture device and its method of use, relating to the field of medical device technology. The suture device includes at least two suture components arranged crosswise and marked with different colors, and an adjustment structure. Each suture component contains biocompatible sutures with multiple fixed points spaced apart, anchored to the wound edge by titanium clips. The adjustment structure is integrated into the handle, allowing adjustment of the suture contraction force and traction direction, and features a locking mechanism to prevent rebound. During use, the fixed points are first anchored, and then the sutures are tightened step-by-step according to the color markings, ensuring uniform wound healing and reinforcement. This invention employs cross-segmented sutures to disperse wound tension, significantly reducing the amount of titanium clips used; the color markings facilitate precise operation, shorten surgical time, eliminate submucosal dead space, and reduce the risk of postoperative complications. It is suitable for closing ESD wounds with a diameter >20mm or irregular shapes.

A cannula comprising a hollow tube made of a biocompatible, thermoplastic polymer, memory shape material, tipped with an injection needle or an electrode at it distal end, assumes desired shapes as it distally emerges from a lumen or channel of an instrument such as an introducer or endoscope. The desires shapes include a curvature conforming to an inverse tangent function. The cannula may be supplied alone, with or without an injection needle or electrode, and in a sterile pouch, for use with a device of a user's choice that has a suitable lumen or channel to guide the cannula, of the cannula may be used without such an instrument. The injection needle can be shorter than conventional to thereby inject medication only or primarily in submucosa and can be sharpened only or mostly at it distal end while the remaining portion of a bevel is not sharp, to thereby reduce the size of an opening the needle makes in tissue and helps keep the medication from leaking out of the injection site.