19 results about "Bacterial pneumonia" patented technology

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation method and application thereof, active ingredients of the traditional Chinese medicine composition including a fermentation product prepared by subjecting traditional Chinese medicine raw materials to anaerobic solid-state fermentation in combination with Lactobacillus helveticus and enzyme preparation; the traditional Chinese medicine raw materials include ginseng, poria cocos, Chinese yam, white lentil, lotus seed, yiyi seed, amomum villosum, platycodon grandiflorum, licorice and dried tangerine or orange peel; and the enzyme preparation includes cellulase and / or cellobiase. The application effectively promotes dissolution of effective ingredients of Shenlingbaizhu powder, significantly enriches antioxidant active ingredients in the fermentation product, relieves inhibition of oxidative stress on immune cells, and greatly improves survival rate and phagocytic efficacy of macrophages, so that the application shows a significant antibacterial pneumonia effect and has an excellent application prospect.

Compositions and methods are provided for treating bacterial infections, including those that are challenging to treat by conventional medications, such as hospital acquired bacterial pneumonia (HABP), ventilator associated bacterial pneumonia (VABP), and bacteremia, caused by carbapenem-resistant bacteria such as Acinetobacter baumannii and Pseudomonas aeruginosa.

The application discloses a dandelion extract capable of neutralizing bacterial toxins and application thereof. The dandelion extract is mainly prepared by the following method: fresh dandelion juice is squeezed, the juice is collected, the juice is centrifuged, the supernatant is collected, the supernatant is ultra-filtered, and components capable of passing through a filter membrane with a molecular weight cut-off of 100 kD and incapable of passing through a filter membrane with a molecular weight cut-off of 3 kD are collected, namely the dandelion extract. The dandelion extract obtained by the application is natural in composition, free of toxic side effects and high in biological activity. Experimental evidence shows that the dandelion extract can protect host cells from attack by directly and specifically combining with toxins, effectively neutralizes the toxicity of bacterial toxins, and has effective prevention and treatment effects on diseases such as systemic bacterial infection, wound infection and bacterial pneumonia. Therefore, the dandelion extract can be used as a new type of anti-microbial and anti-infection functional material and applied to the fields of functional food, health products, medicines or functional cosmetics.

The application discloses a traditional Chinese medicine composition for preventing and treating pig bacterial pneumonia and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following components: Ephedra, apricot kernel, gypsum, Astragalus root, Anemarrhena asphodeloides, Cape jasmine fruit, talc, licorice, honeysuckle, forsythia, rhubarb, mirabilite, peony root and kudzurpini radix. The application studies and clinically applies traditional Chinese medicine by combining traditional preparation technology with modern preparation technology, and adopts the traditional Chinese medicine compound prepared through fermentation to prevent and treat pig bacterial pneumonia, so as to solve the above problems. Through clinical application, the traditional Chinese medicine compound has a treatment effect on pig bacterial pneumonia, and the cure rate can reach 91.83%, and the cure rate can reach 95.97% after fermentation, the drug efficacy is improved, the recurrence is difficult, and there is no drug residue. In addition, the components are common traditional Chinese medicines, the cost is low, the safety is high, and there is no side effect. The application not only reduces the economic loss of breeders, but also meets the demand of people for green food, and conforms to the development trend.

The invention is suitable for the technical field of medical intelligent diagnosis and machine learning, and provides a pneumonia screening and risk prediction model construction method based on a reverse neural network, and the method comprises the steps: firstly carrying out the preprocessing of a bacterial pneumonia clinical symptom data set, and dividing a multi-classification problem into a plurality of binary classification tasks; secondly, constructing a CPT algorithm based on a random forest and a convex hull theory, calculating a feature weight through information gain, and screening out high-contribution symptom features; and finally, inputting the screened features into the optimized BPNN, and obtaining a prediction model through repeated iterative training. The method has good classification accuracy, the number of the selected features is obviously reduced compared with a traditional model, and the method can be used as a clinical auxiliary diagnosis tool, is applied to clinical bacterial pneumonia infection screening and severe risk early warning, and provides decision support for timely treatment.

Methods for treating or preventing bacterial pneumonia in a subject involve administration of a Prevotella composition to the subject. The Prevotella composition may include cells, or portions thereof, of one or more of P. melaninogenica, P. buccae, P. tannerae, and P. nanceiensis. The composition may be administered by inhalation.

The present application relates to the technical field of nanocarrier, and discloses a multifunctional nanocarrier, a preparation method and application thereof.The multifunctional nanocarrier comprises ginsenoside Rb1 and a cationic polymer, and the cationic polymer is one of polyaminopropyl biguanide PAPB, chitosan CS, polyacrylamide PAM or polyethylenimine PEI.The preparation method is as follows: the ginsenoside is dispersed in physiological saline, a cationic polymer solution is added, and the mixed solution is ultrasonically treated to obtain the multifunctional nanocarrier.The multifunctional nanocarrier, the preparation method and application thereof can specifically target macrophages, can not only promote the macrophage-mediated delivery of Rb1 to the inflammation site in a sepsis-related acute lung injury (ALI) model, relieve inflammation, but also can improve the bacterial clearance rate in blood infection-related ALI and bacterial pneumonia models, reduce inflammation and immune response, and can be used for developing drugs for treating chronic inflammation.

The invention provides application of tetrathiomolybdate in preparation of drugs for inhibiting inflammatory factor storm, and belongs to the technical field of drugs for treating inflammatory factor storm and respiratory system diseases. The general molecular formula of the tetrathiomolybdate is X < + > MoS < 42-Y < + >, and the positions of ionic bonds of four sulfur ions of the tetrathiomolybdate are interchangeable; x + and Y + are the same or different cations; the positive ions are inorganic positive ions and / or organic positive ions which can be dissociated in a solution to generate MoS < 2-> or can be subjected to enzymolysis in a biological system to generate MoS < 2->. The invention discloses unique advantages of a single drug scheme in inflammatory factor storm and respiratory system related diseases, especially bacterial acute respiratory system inflammation, for the first time, and tetrathiomolybdate is used as a single active component for preparing the drug for treating bacterial pneumonia and non-viral acute lung injury / acute respiratory distress syndrome.

The application discloses a volatile oil emulsion of phellodendri chinensis leaves and a preparation method and application thereof, and relates to the field of agricultural and sideline product processing. Specifically, the volatile oil emulsion of phellodendri chinensis leaves comprises the following components: 80-150 parts by weight of volatile oil of phellodendri chinensis leaves, 70-180 parts by volume of an emulsifier, and 1200-2000 parts by volume of water; wherein the volatile oil of phellodendri chinensis leaves is obtained by water vapor distillation. The volatile oil emulsion of phellodendri chinensis leaves has high stability, good palatability, and obvious inhibitory effect on staphylococcus aureus. In addition, the volatile oil emulsion of phellodendri chinensis leaves can effectively alleviate pneumonia of mice infected by staphylococcus aureus, inhibit the activation of NLRP3 inflammasome and the production of inflammatory factors; therefore, the volatile oil emulsion of phellodendri chinensis leaves has an auxiliary treatment effect on bacterial pneumonia and has a good application prospect.

Provided are methods of treating hospital- acquired bacterial pneumonia and ventilator- associated bacterial pneumonia (HABP / VABP) caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complex using durlobactam and sulbactam.

The invention discloses a pharmaceutical composition containing a pseudo-ginseng extract as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The invention provides a pharmaceutical composition containing a pseudo-ginseng extract, and tests prove that the pharmaceutical composition containing the pseudo-ginseng extract has a treatment effect on bacterial pneumonia induced by klebsiella pneumonia. Specifically, the pharmaceutical composition containing the pseudo-ginseng extract can significantly reduce the levels of IL-6, IL-1beta and TNF-alpha in alveolar lavage fluid; the mouse lung index is obviously reduced; the bacterial load in the lung tissue of the mouse is obviously reduced; the mouse lung tissue injury degree is obviously reduced; the number of neutrophils and the number of leukocytes in mouse blood are obviously reduced; the composition also has the effect of remarkably relieving increase of inflammatory factors in serum caused by klebsiella pneumoniae, and the effect is equivalent to or superior to that of a positive control drug ceftriaxone sodium. The invention provides a new choice and idea for clinical treatment of bacterial pneumonia.

The invention relates to the technical field of biological medicines, and discloses application of calcium phosphate-loaded bacterial membrane vesicles in preparation of a preparation for enhancing a bacterial pneumonia prevention effect. The bacterial membrane vesicles are derived from pseudomonas aeruginosa, klebsiella pneumoniae or acinetobacter baumannii; the extraction and purification of the bacterial membrane vesicles comprises the following steps: respectively selecting standard strains, namely pseudomonas aeruginosa, klebsiella pneumoniae and acinetobacter baumannii, and activating and culturing to a logarithmic phase; after the culture is completed, collecting bacterial supernatant through room-temperature centrifugation; and purifying the BMVs crude extract by using a gel filtration chromatography column. According to the application of the bacterial membrane vesicle loaded with the calcium phosphate in preparation of the preparation for enhancing the bacterial pneumonia prevention effect, the calcium phosphate is adopted as a broad-spectrum immunologic adjuvant, an immunologic enhancement system of the calcium phosphate and the bacterial membrane vesicle is efficient, universal and high in targeting specificity, corresponding pathogenic bacterium infectious pneumonia can be accurately prevented, and the preparation method is suitable for large-scale popularization and application. The prevention efficiency of the preparation is obviously improved; meanwhile, the preparation process is simple and mild, and the biological safety is high.

The invention discloses a kit and method for detecting myxovirus drug-resistant protein A based on polypeptide and application, and belongs to the technical field of proteomics. The amino acid sequence of the polypeptide is as shown in SEQ ID No. 29. The polypeptide is obtained based on enzymolysis of an MxA standard substance and screening, a standard curve is established by utilizing the polypeptide and isotope labeled polypeptide, a biological sample is further subjected to enzymolysis to obtain a peptide fragment sample, and MxA in the biological sample can be quantified by detecting the content of the polypeptide in the peptide fragment sample. By utilizing the method disclosed by the invention, the MxA in the biological sample can be rapidly quantified, so that the viral pneumonia and the bacterial pneumonia are diagnosed and distinguished, and the accuracy rate is high.

The invention discloses an OMVs (at) Se bioactive preparation as well as a preparation method and application thereof. According to the preparation, a core-shell structure is formed by coating bacterial outer membrane vesicles with selenium nanoparticles, targeted delivery to lung macrophages is achieved, ferroptosis of the lung macrophages is effectively inhibited, inflammatory response is cooperatively regulated, the immune clearance ability is enhanced, and therefore the efficient immunotherapy effect on bacterial pneumonia is achieved.

Provided are methods of treating hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP / VABP) caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complex using durlobactam and sulbactam.

An explainable artificial intelligence system for early prediction of missed severe diagnoses in intensive care unit patients is provided. The system comprises a data processing module configured to receive and process electronic health record data including patient demographics, vital signs, laboratory results, and diagnostic codes. A machine learning module with ensemble, deep learning, and large language models analyzes processed data to predict likelihood of severe diagnoses including acute myocardial infarction, acute pulmonary embolism, bacterial pneumonia, aortic dissection, meningitis, spinal abscess, bacterial endocarditis, and arterial thromboembolism. An explainability module generates feature importance rankings and provides interpretable explanations for predictions.

Provided are methods of treating hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP / VABP) caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complex using durlobactam and sulbactam.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a composition capable of resisting bacterial pneumonia, a preparation method and application. The composition is prepared by fermenting a mixture of a traditional Chinese medicine composition, oligoisomaltose and a peppermint-flavored powder through complex probiotics. The raw materials of the traditional Chinese medicine composition are 10-25 parts of leaves of loquat, 5-15 parts of momordica grosvenori, 5-15 parts of licorice, 2-10 parts of orange peel and 1-8 parts of fat sea. The complex probiotics are plant lactobacillus HCS03-001, royi mucous lactobacillus HCS02-001 and rhamnose lactobacillus HCS01-013 with a mass ratio of 1-2:1:1. The application uses an extract of homologous raw materials of food and medicine as a culture medium for fermentation, and a composition produced by specific lactic acid bacteria can be used for preparing an anti-bacterial pneumonia product.