57 results about "Bacterial pneumonia" patented technology

The invention provides a composition capable of penetrating an intestinal barrier by oral administration. The composition contains a carrier or an auxiliary material of a targeted Microflod cell Dectin-1 receptor, and one or / and a plurality of medicinal components / components, wherein the carrier or the auxiliary material of the target Microflood cell Dectin-1 receptor is beta-glucan, and the carrier or the auxiliary material of the target Microflood cell Dectin-1 receptor is beta-glucan. The effective components / components are traditional Chinese medicine effective components / components, or / and probiotics, or / and chemical medicine components, or / and biological medicines. The invention relates to a composition capable of realizing oral administration and penetrating through an intestinal barrier, which is based on the discovery of the inventor that the composition reaches colon through gastrointestinal tracts, targets colon Microflood cells, is taken by the Microflood cells, penetrates through the intestinal barrier and enters immune tissue Colonic Patches of a colon submucosa. Based on the research, the composition disclosed by the invention can be used for treating various diseases, such as ulcerative colitis, Crohn's disease, colon cancer, rheumatoid arthritis or bacterial pneumonia after being orally taken and absorbed by rectum.

The invention relates to a bacterial pneumonia pathogenic bacterium identification method based on an intelligent Raman technology, which comprises the following steps: S1, setting a type label according to a gram staining characteristic classification mode or the occurrence frequency of bacterial types in bacterial pneumonia infection, and selecting a known strain according to the type label, collecting Raman spectrum data of a known strain; s2, carrying out wave number extraction, background subtraction, smooth noise reduction and normalization preprocessing on the Raman spectrum data; s3, constructing a classification model according to an AlexNet model; s4, dividing the preprocessed Raman spectrum data into a training set and a verification set, and inputting the training set, the verification set and corresponding type labels into a classification model for training to obtain a trained classification model; and S5, acquiring Raman spectrum data of detected bacteria by using a Raman spectrometer, preprocessing the Raman spectrum data, and inputting the preprocessed Raman spectrum data into the trained classification model to obtain the type of the detected bacteria. The bacteria are identified by establishing the classification model, so that the operation complexity is reduced, and the identification time is shortened.

The invention relates to the technical field of probiotic preparations, in particular to an Ackerman bacterium probiotic preparation and application of the Ackerman bacterium probiotic preparation in prevention of bacterial pneumonia of chicks, the Ackerman bacterium probiotic preparation is prepared from the following raw materials in parts by weight: 40-60 parts of compound probiotics, 10-25 parts of prebiotics, 10-18 parts of a carrier and 8-15 parts of a freeze-drying protective additive, the preparation method of the Ackerman bacteria probiotic preparation comprises the following steps: adding the prebiotics and the freeze-drying protective agent into sterile water, and uniformly stirring to prepare a mixed solution; and fully mixing the composite probiotics with the mixed solution and the carrier, performing freeze drying, controlling the water content to be 3-5% after drying, and performing granulation to obtain the Ackerman bacteria probiotic preparation. The Ackerman bacterium probiotic preparation can significantly reduce the morbidity and mortality of bacterial pneumonia of chicks, and provides a new efficient and green disease prevention and control strategy for the poultry breeding industry.

According to the magnetic multifunctional nano-drug, on the basis of traditional ZIF-8, iron ions and defect structures are introduced, a synergistic antibacterial mode of magnetocaloric therapy-sonodynamic therapy-chemodynamic therapy is established for the first time, heat is generated under an alternating magnetic field, and the magnetic multifunctional nano-drug is used for treating bacterial pneumonia. Active oxygen is rapidly generated under ultrasound, existence of iron ions causes Fenton reaction to achieve chemical power therapy and induce ferroptosis to achieve synergistic antibiosis, release of zinc ions promotes polarization of macrophages to reduce inflammation of disease sites, the problems that focus depth is deep, drug resistance is generated, single treatment effect is poor and the like can be solved, and the treatment effect is good. A new thought is provided for treating the bacterial pneumonia.

The invention relates to application of a traditional Chinese medicine composition in preparation of a medicine for treating or preventing bacterial pneumonia. The traditional Chinese medicine composition comprises 1-3 parts of honey-fried ephedra, 1-10 parts of semen armeniacae amarae, 1-6 parts of platycodon grandiflorum, 1-6 parts of radix peucedani, 1-6 parts of thunberg fritillary bulb, 1-6 parts of radix stemonae, 1-3 parts of oroxylum indicum, 1-10 parts of radix glehniae and 1-3 parts of liquorice. The traditional Chinese medicine composition can obviously reduce leukocyte count and neutrophil of lipopolysaccharide induced pneumonia model rats, increase the percentage of lymphocytes and platelets, and has the effects of inhibiting body inflammatory response, removing antigens and promoting body recovery.

The invention belongs to the technical field of preparation of antibacterial and anti-inflammatory nanoparticles, and particularly relates to a preparation method of magnetocaloric nanoparticles based on piezoelectric catalytic molybdenum disulfide nanoflowers, and the preparation method comprises the following steps: S1, preparing MoS2; in the step S1, MoS2 is prepared by the following steps: weighing 1.235 g of ammonium molybdate and 1.052 g of thioacetamide, dissolving the ammonium molybdate and the thioacetamide in 20 mL of deionized water, and uniformly stirring to obtain a colorless transparent solution; transferring into a 50mL high-pressure reaction kettle, and reacting at 220 DEG C for 8 hours; and repeatedly washing with distilled water and absolute ethyl alcohol for multiple times, and carrying out vacuum drying on the product at 60 DEG C for 48 hours to obtain MoS2. According to the novel antibacterial nano material integrating MHT, PCT and enzyme activity, the synergistic effect of each single treatment means is enhanced, multiple antibacterial effects are achieved, and the treatment efficiency of bacterial pneumonia is improved.

The invention discloses an integrated nano-enzyme with multiple response mechanism synergism, and a preparation method and application thereof. A Z-type heterojunction based on boron nanosheets (B NSs) and rare earth doped iron phosphide (Nd < 0.02 > Fe < 1.98 > P) is constructed for the first time, and CTAB is used for surface modification to obtain a ternary composite nano-enzyme (BFC); according to the present invention, the material is endowed with the multi-response ability (POD / GSHOx enzyme activity synergistic activation) on the bacterial infection microenvironment (low pH and high H2O2), and the nano-enzyme has excellent acoustic-magnetic responsiveness, can break through the depth limitation, and can achieve the precise and controllable generation of the reactive oxygen species (ROS). Under the acidic microenvironment of pulmonary infection, the activity of peroxidase (POD) and glutathione oxidase (GSHOx) is activated, so that efficient and controllable synergistic killing is performed on bacteria.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation method and application thereof, active ingredients of the traditional Chinese medicine composition including a fermentation product prepared by subjecting traditional Chinese medicine raw materials to anaerobic solid-state fermentation in combination with Lactobacillus helveticus and enzyme preparation; the traditional Chinese medicine raw materials include ginseng, poria cocos, Chinese yam, white lentil, lotus seed, yiyi seed, amomum villosum, platycodon grandiflorum, licorice and dried tangerine or orange peel; and the enzyme preparation includes cellulase and / or cellobiase. The application effectively promotes dissolution of effective ingredients of Shenlingbaizhu powder, significantly enriches antioxidant active ingredients in the fermentation product, relieves inhibition of oxidative stress on immune cells, and greatly improves survival rate and phagocytic efficacy of macrophages, so that the application shows a significant antibacterial pneumonia effect and has an excellent application prospect.

The invention belongs to the technical field of medicine preparation, and particularly relates to a nitraria tangutorum composite medicine, which is prepared from the following raw materials in parts by weight: 10 to 30 parts of nitraria tangutorum, 0 to 30 parts of herba elsholtziae, 0 to 20 parts of pink reineckea herb and 0 to 20 parts of stevia rebaudiana. The preparation method comprises the following steps: respectively cleaning and drying the sophora davidii, the elsholtzia, the pink reineckea herb and the stevia rebaudiana according to the proportion, crushing into powder, and uniformly mixing to obtain raw material powder of the sophora davidii combined medicine. The raw material powder can be further prepared into dosage forms such as granules, tablets, capsules or oral liquid. The nitraria tangutorum var. Davidii combined medicine is applied to treatment of pneumonia including bacterial pneumonia, viral pneumonia and the like.

The present invention provides an inhalable bionic nanomaterial for treating bacterial pneumonia of the lungs, and a preparation method and application thereof, belonging to the technical field of drug preparation. Mesoporous polydopamine nanoparticles A are prepared by a one-pot synthesis method using block polyether and 3,3',5,5'-tetramethylbenzidine as templates; levofloxacin is added to A, stirred and centrifuged, and freeze-dried to obtain nanoparticles B; RAW264.7 cells are resuspended after centrifugation, homogenized and centrifuged again to collect the supernatant, and the supernatant centrifugal precipitation is the prepared macrophage membrane C; the configured B solution and C are mixed, and a bionic nanomaterial D wrapped in a macrophage membrane coating is prepared by a direct extrusion method. The inhalable bionic nanomaterial prepared by the present invention can cross the complex lung barrier to target the inflammatory site to respond to the release of drugs, and can remove reactive oxygen to relieve lung inflammation, which is of great significance for the treatment of lung infection and has promotion and application value.

Compositions and methods are provided for treating bacterial infections, including those that are challenging to treat by conventional medications, such as hospital acquired bacterial pneumonia (HABP), ventilator associated bacterial pneumonia (VABP), and bacteremia, caused by carbapenem-resistant bacteria such as Acinetobacter baumannii and Pseudomonas aeruginosa.

The application discloses a dandelion extract capable of neutralizing bacterial toxins and application thereof. The dandelion extract is mainly prepared by the following method: fresh dandelion juice is squeezed, the juice is collected, the juice is centrifuged, the supernatant is collected, the supernatant is ultra-filtered, and components capable of passing through a filter membrane with a molecular weight cut-off of 100 kD and incapable of passing through a filter membrane with a molecular weight cut-off of 3 kD are collected, namely the dandelion extract. The dandelion extract obtained by the application is natural in composition, free of toxic side effects and high in biological activity. Experimental evidence shows that the dandelion extract can protect host cells from attack by directly and specifically combining with toxins, effectively neutralizes the toxicity of bacterial toxins, and has effective prevention and treatment effects on diseases such as systemic bacterial infection, wound infection and bacterial pneumonia. Therefore, the dandelion extract can be used as a new type of anti-microbial and anti-infection functional material and applied to the fields of functional food, health products, medicines or functional cosmetics.

The application discloses a traditional Chinese medicine composition for preventing and treating pig bacterial pneumonia and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following components: Ephedra, apricot kernel, gypsum, Astragalus root, Anemarrhena asphodeloides, Cape jasmine fruit, talc, licorice, honeysuckle, forsythia, rhubarb, mirabilite, peony root and kudzurpini radix. The application studies and clinically applies traditional Chinese medicine by combining traditional preparation technology with modern preparation technology, and adopts the traditional Chinese medicine compound prepared through fermentation to prevent and treat pig bacterial pneumonia, so as to solve the above problems. Through clinical application, the traditional Chinese medicine compound has a treatment effect on pig bacterial pneumonia, and the cure rate can reach 91.83%, and the cure rate can reach 95.97% after fermentation, the drug efficacy is improved, the recurrence is difficult, and there is no drug residue. In addition, the components are common traditional Chinese medicines, the cost is low, the safety is high, and there is no side effect. The application not only reduces the economic loss of breeders, but also meets the demand of people for green food, and conforms to the development trend.

The invention relates to the technical field of nano-carriers, and discloses a multifunctional nano-carrier as well as a preparation method and application thereof. The multifunctional nano-carrier comprises ginsenoside Rb1 and a cationic polymer, and the cationic polymer is one of poly (aminopropyl) biguanide (PAPB), chitosan (CS), polyacrylamide (PAM) or polyethyleneimine (PEI). The preparation method comprises the following steps: dispersing ginsenoside in normal saline, adding a cationic polymer solution, and carrying out ultrasonic treatment on the mixed solution to obtain the multifunctional nano-carrier. According to the multifunctional nano-carrier and the preparation method and application thereof, the multifunctional nano-carrier can specifically target macrophages, in a septicemia-related acute lung injury ALI model, macrophage-mediated Rb1 is promoted to be delivered to an inflammation part, inflammation is relieved, and the anti-inflammatory effect is achieved. The clearance rate of ALI related to blood infection and bacteria in a bacterial pneumonia model can be improved, and inflammation and immune response are relieved; the compound can be used for developing medicines for treating chronic inflammation.

The invention is suitable for the technical field of medical intelligent diagnosis and machine learning, and provides a pneumonia screening and risk prediction model construction method based on a reverse neural network, and the method comprises the steps: firstly carrying out the preprocessing of a bacterial pneumonia clinical symptom data set, and dividing a multi-classification problem into a plurality of binary classification tasks; secondly, constructing a CPT algorithm based on a random forest and a convex hull theory, calculating a feature weight through information gain, and screening out high-contribution symptom features; and finally, inputting the screened features into the optimized BPNN, and obtaining a prediction model through repeated iterative training. The method has good classification accuracy, the number of the selected features is obviously reduced compared with a traditional model, and the method can be used as a clinical auxiliary diagnosis tool, is applied to clinical bacterial pneumonia infection screening and severe risk early warning, and provides decision support for timely treatment.

The invention disclosed herein provides a method for treating Community-Acquired Bacterial Pneumonia (CABP) using 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, in either oral or IV doses or a combination of both.

Methods for treating or preventing bacterial pneumonia in a subject involve administration of a Prevotella composition to the subject. The Prevotella composition may include cells, or portions thereof, of one or more of P. melaninogenica, P. buccae, P. tannerae, and P. nanceiensis. The composition may be administered by inhalation.

The present invention refers to an in vitro method for identifying biomarkers or biomarker signatures for the differential diagnosis between viral and bacterial pneumonia in a patient, for the differential diagnosis between viral and bacterial pneumonia in a patient and / or for selecting a therapy for a patient suffering from pneumonia.

To provide a method for treating Community-Acquired Bacterial Pneumonia (CABP).SOLUTION: A method comprises administering, to a subject, 9-[(2,2-dimethyl-propylamino)-methyl]-minocycline or a salt thereof according to a following dosing regimen: (1) three intravenous doses of about 100 mg each, which are administered every 12 hours; (2) subsequent optional one or more intravenous doses of about 100 mg each, each of which is administered 24 hours after the immediate preceding intravenous dose; (3) subsequent optional one oral dose of about 300 mg, which is administered in the morning and 12-24 hours after the immediate preceding intravenous dose; and (4) subsequent optional one or more oral doses of about 300 mg each, each of which is administered 24 hours after the immediate preceding oral dose.SELECTED DRAWING: Figure 1

The present invention discloses the application of a strain in constructing an animal pneumonia model and a construction method, and belongs to the technical field of animal model construction. By adopting the infection strain and construction method provided by the present invention, it is not necessary to inject rats with immunosuppressants such as cyclophosphamide before infection. The rats only need to be adaptively raised to be successfully infected and modeled, which simulates the real infection scene to the maximum extent, shortens the experimental cycle, and saves the experimental cost; the constructed rat pneumonia model is stable for a long time, and by the end of the observation, the lung pathological symptoms and blood infection symptoms have always existed, the sick rats do not heal themselves, and the lungs are severely damaged; the infection strain and construction method provided can provide a reference for the establishment of other bacterial pneumonia models, thereby further laying the foundation for the development of pneumonia drugs and the research on their mechanism of action, and providing more basis and inspiration for clinical guidance of medication.

The present application relates to the technical field of nanocarrier, and discloses a multifunctional nanocarrier, a preparation method and application thereof.The multifunctional nanocarrier comprises ginsenoside Rb1 and a cationic polymer, and the cationic polymer is one of polyaminopropyl biguanide PAPB, chitosan CS, polyacrylamide PAM or polyethylenimine PEI.The preparation method is as follows: the ginsenoside is dispersed in physiological saline, a cationic polymer solution is added, and the mixed solution is ultrasonically treated to obtain the multifunctional nanocarrier.The multifunctional nanocarrier, the preparation method and application thereof can specifically target macrophages, can not only promote the macrophage-mediated delivery of Rb1 to the inflammation site in a sepsis-related acute lung injury (ALI) model, relieve inflammation, but also can improve the bacterial clearance rate in blood infection-related ALI and bacterial pneumonia models, reduce inflammation and immune response, and can be used for developing drugs for treating chronic inflammation.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a composition capable of resisting bacterial pneumonia, a preparation method and application. The composition is prepared by fermenting a mixture of a traditional Chinese medicine composition, isomaltooligosacharide and mint powder through compound probiotics, and the traditional Chinese medicine composition comprises the following raw materials: 10-25 parts of loquat leaves, 5-15 parts of momordica grosvenori, 5-15 parts of liquorice, 2-10 parts of orange peel and 1-8 parts of scaphium scaphigerum. The compound probiotics are prepared from the following components in parts by mass: 1 to 2 parts of plant lactobacillus HCS03-001, 1 to 1 part of lactobacillus reuteri HCS02-001 and 1 part of lactobacillus rhamnosus HCS01-013. The medicinal and edible raw material extracting solution is used as a culture medium for fermentation, and the composition generated by combining specific lactic acid bacteria can be used for preparing bacterial pneumonia resisting products.

The invention belongs to the technical field of biological medicines, and particularly relates to application of acetyl coenzyme A in preparation of a medicine for treating pneumonia. In the invention, klebsiella pneumoniae is used as a representative, the improvement effect of the acetyl coenzyme A on mice with bacterial infectious pneumonia is researched, and the result shows that the acetyl coenzyme A can reduce the lung index of the mice with bacterial pneumonia to different degrees, can reduce the bacterial load in the lung tissue of the mice with bacterial pneumonia, and can improve the lung index of the mice with bacterial pneumonia. The injury of lung tissues of mice with bacterial pneumonia can be improved, and the expression level of inflammatory factors in the lung tissues of the mice with bacterial pneumonia and the oxidative stress level of the lung tissues can be reduced. In conclusion, the invention provides a new application of the acetyl coenzyme A, and a new thought and a theoretical basis are provided for treatment of the bacterial pneumonia.

The invention provides application of tetrathiomolybdate in preparation of drugs for inhibiting inflammatory factor storm, and belongs to the technical field of drugs for treating inflammatory factor storm and respiratory system diseases. The general molecular formula of the tetrathiomolybdate is X < + > MoS < 42-Y < + >, and the positions of ionic bonds of four sulfur ions of the tetrathiomolybdate are interchangeable; x + and Y + are the same or different cations; the positive ions are inorganic positive ions and / or organic positive ions which can be dissociated in a solution to generate MoS < 2-> or can be subjected to enzymolysis in a biological system to generate MoS < 2->. The invention discloses unique advantages of a single drug scheme in inflammatory factor storm and respiratory system related diseases, especially bacterial acute respiratory system inflammation, for the first time, and tetrathiomolybdate is used as a single active component for preparing the drug for treating bacterial pneumonia and non-viral acute lung injury / acute respiratory distress syndrome.

The application discloses a volatile oil emulsion of phellodendri chinensis leaves and a preparation method and application thereof, and relates to the field of agricultural and sideline product processing. Specifically, the volatile oil emulsion of phellodendri chinensis leaves comprises the following components: 80-150 parts by weight of volatile oil of phellodendri chinensis leaves, 70-180 parts by volume of an emulsifier, and 1200-2000 parts by volume of water; wherein the volatile oil of phellodendri chinensis leaves is obtained by water vapor distillation. The volatile oil emulsion of phellodendri chinensis leaves has high stability, good palatability, and obvious inhibitory effect on staphylococcus aureus. In addition, the volatile oil emulsion of phellodendri chinensis leaves can effectively alleviate pneumonia of mice infected by staphylococcus aureus, inhibit the activation of NLRP3 inflammasome and the production of inflammatory factors; therefore, the volatile oil emulsion of phellodendri chinensis leaves has an auxiliary treatment effect on bacterial pneumonia and has a good application prospect.

The application belongs to the technical field of traditional Chinese medicine preparation, and discloses a traditional Chinese medicine composition, a preparation method and application thereof. One of the traditional Chinese medicine compositions comprises the following raw materials in parts by weight: Cyclobalanopsis glauca 50-80 parts, tartary buckwheat 30-50 parts, polygonatum 30-50 parts, honeysuckle 30-50 parts, Poria cocos 10-20 parts, gordon euryale seed 10-20 parts, lotus seed 10-20 parts, medlar 10-20 parts, angelica 10-20 parts, yam 5-15 parts, hawthorn 5-15 parts, and sour jujube seed 5-15 parts. The compound preparation has a good blood glucose-lowering effect, can correct the lipid metabolism disorder of diabetic rats, and reduce liver function damage, has a certain protective effect on the liver, and can be applied to the preparation of a medicine for treating non-alcoholic fatty liver. On this basis, in addition to adding part of the medicinal materials, the traditional Chinese medicine composition can also be applied to the preparation of a medicine for treating chronic obstructive pulmonary disease and a medicine for treating bacterial pneumonia.

The invention discloses application of a strain in construction of an animal pneumonia model and a construction method, and belongs to the technical field of animal model construction. By adopting the infection strain and the construction method provided by the invention, an immunosuppressive agent such as cyclophosphamide does not need to be injected into a rat before infection, and artificial infection success modeling can be realized only by adaptively feeding the rat, so that a real infection scene is simulated to the greatest extent, the experimental period is shortened, and the experimental cost is saved; the constructed rat pneumonia model is stable for a long time, lung pathological symptoms and blood infection symptoms always exist until observation is finished, diseased rats do not heal, and the lungs are seriously injured; the provided infection strain and the construction method can provide reference for the establishment of other bacterial pneumonia models, so that a foundation is further laid for the development of pneumonia drugs and the research on the action mechanism of the pneumonia drugs, and more bases and inspiration are provided for clinical guidance of medication.

The invention relates to the technical field of probiotic preparations, and particularly discloses a composition of Ackermann muciniphila and prebiotics and application of the composition in prevention and treatment of poultry bacterial pneumonia. The composition of Ackermann muciniphile and prebiotics is prepared by the following method: performing high-density fermentation culture on Ackermann muciniphile, and performing centrifugation, washing and freeze drying to prepare high-activity bacterial powder; the prebiotics are mixed with the high-activity bacterial powder in proportion after being purified and sterilized, and the activity of the bacterial strain in the storage and use process is protected by adopting a microcapsule embedding technology. The product can be prepared into powder, granules or liquid dosage forms, is convenient to add into poultry feed or drinking water, is added into the feed or drinking water according to the proportion of 0.1-0.5% in the susceptible period of poultry, and can remarkably reduce the incidence rate of poultry bacterial pneumonia after being continuously used for 7-14 days.

The invention discloses a composition for improving lung injury of dogs after bacterial infection as well as a preparation method and application thereof, and relates to the technical field of animal health care products. The composition is prepared from a honeysuckle flower extract, fish collagen peptide, a herba houttuyniae extract, L-carnitine, isoleucine, valine, taurine, glutamine, L-glutamic acid, L-lysine, L-threonine, L-histidine, succinic acid, L-proline, methionine, cysteine and glycine. The composition can effectively relieve dog lung epithelial cell injury caused by streptococcus pneumoniae infection, reduce intracellular lactic dehydrogenase release, improve cellular morphology and reduce inflammatory response and oxidative stress level. The composition disclosed by the invention can improve respiratory tract discomfort symptoms, such as high cough frequency, increased mucus secretion, poor mental state and the like, which still exist after the treatment of the dog bacterial pneumonia through a multi-target effect. The health recovery level of the dogs after conventional antibiotic treatment can be improved.