33results about How to "Significant antitussive effect" patented technology

The invention relates to a Chinese medicinal composition for clearing heat, dispersing phlegm, ventilating the lung and relieving asthma and process for preparation, wherein the composition comprises Chinese ephedra, licorice root, bitter apricot seed, radish seeds, lepidium seed, purple perilla seed, baikal skullcap root, mulberry bark, clerodendroa cyrtophyllum, cordate houttuynia and gypsum.

A preparation method of a potentilla anserina L. root crude polysaccharide with potentilla anserina L. root as raw material and a use are provided. The method comprises the steps: taking the potentilla anserina L. root medicinal material, and crushing to obtain a potentilla anserina L. root powder; taking the potentilla anserina L. root powder; adding 5-20 times the amount of 60-95% alcohol for immersion or refluxing extraction for 0.5-2 h, repeating 2-3 times, and filtering to remove the alcohol solution; adding water with at least 4 times the weight of the potentilla anserina L. root powder into the potentilla anserina L. root dregs, heating for extraction, after finishing extraction, cooling to the room temperature, filtering to obtain a filtrate, extracting, and repeating 2-3 times; merging the filtrates; carrying out reduced pressure concentration of the merged filtrate until the volume is 1 / 6-1 / 3 that of the original merged filtrate; adding 4 times the amount of 95% ethanol into the concentrated solution, then standing for 24-72 h at the temperature of 4 DEG C, and centrifuging to obtain a crude polysaccharide precipitate; and respectively washing the precipitate with ethanol and acetone for a plurality of times, and carrying out freeze drying to obtain a potentilla anserina L. root polysaccharide extract. The prepared polysaccharide has the antitussive use.

The invention discloses a Manchurian wildginger total polysaccharide extract with cough-relieving activity and a preparation method and application thereof, belonging to the technical field of medicines. The Manchurian wildginger total polysaccharide extract is prepared by subjecting the root and / or tuber of Manchurian wildginger to extraction with a polar solvent, carrying out ethanol precipitation and then carrying out drying under reduced pressure, wherein the yield and the content of the total polysaccharide are 15 wt% and 60 to 80 wt%, respectively. Through a great number of pharmacodynamic tests, it is proved for the first time that the Manchurian wildginger total polysaccharide extract has a substantial cough inhibiting effect which is close to a treatment effect of codeine and shows a better effect on prolonging the incubation period of cough compared with codeine, and it is found out for the first time that the Manchurian wildginger total polysaccharide extract is capable of reducing sensitivity of cough and inhibiting airway inflammations, has good prevention and treatment effects on a variety of cough and can be used for preparation of drugs used for treating diseases related to cough. The Manchurian wildginger total polysaccharide extract has the advantages of definite activity, usage of original plants as experimental materials and low cost.

The invention provides a composition for preventing pneumoconiosis and a preparation method thereof, wherein the composition is prepared from cordyceps militaris, frosted mulberry leaves, tea polyphenols, gingkgo, fructus monordicae extracts, barbary wolfberry fruits, peach kernels, apricot kernels, and malto dextrin, and the preparation method comprises the steps of: (1) soaking the gingkgo, barbary wolfberry fruits, frosted mulberry leaves, peach kernels and apricot kernels in water; (2) heating the soaked materials to be boiling, leaching, then carrying out flocculation precipitation on leach liquor, and concentrating a supernatant fluid into a thick paste; (3) continuously adding water into the rest materials, heating and leaching; (4)mixing and concentrating the two-time extracts into a thick paste, carrying out vacuum drying and then crushing; (5) sieving the extract, and fully mixing with the cordyceps militaris nano powder, malto dextrin, tea polyphenols and fructus monordicae extracts; and (6) fully mixing the extract with the mixture to be uniform, mixing with alcohol, and palletizing. The composition has an obvious free radical scavenging action, reduces ceruloplasmin, obviously restrains pneumoconiosis fibrosis, and greatly improves the respiratory symptoms of patients with pneumoconiosis.

The invention discloses an asarum total lignan extract and a preparation method and application thereof, belonging to the technical field of medicines. The preparation method comprises the following steps: extracting the root and / or tuber of asarum with a polar solvent and then carrying out concentration and drying so as to obtain an asarum total extract; and dissolving the asarum total extract with water, injecting the dissolved asarum total extract into a macroporous adsorption resin, carrying out gradient elution by using an aqueous ethanol solution, collecting eluate, recovering the solvent and carrying out drying so as to obtain the asarum total lignan extract with a content of 60 to 80 wt%, wherein yield of the asarum total lignan extract is 8.4 wt%. Through a great number of pharmacodynamic tests, it is proved for the first time that the asarum total lignan extract has substantial cough-inhibiting and cough reflex sensitivity-lowering effects which are close to the effects of codeine, and it is found out that the asarum total lignan extract has effects on inhibiting airway inflammations, reducing coughing frequencies and prolonging the incubation period of cough, exerts good prevention and treatment effects on a variety of coughs and can be used for preparation of drugs used for treating diseases related to cough. The asarum total lignan extract has the advantages of definite activity, usage of original plants as experimental materials and low cost.

The invention discloses a Chinese medicinal herb-containing feed additive capable of preventing weaned pig multisystem failure syndrome and pig feed containing the Chinese medicinal herb-containing feed additive. The Chinese medicinal herb-containing feed additive comprises the following ingredients: root of hairy asiabell, bighead atractylodes rhizome, tuckahoe, Chinese yam, radix astragali, white hyacinth bean, coix seed, lotus seed, fructus amomi, dried tangerine or orange peel, parched medicated leaven, parched malt, parched hawthorn fruit, Platycodon grandiflorum, lily, radix stemonae, Polygonum multiflorum, herba epimedii, glossy privet fruit, herba ecliptae, Coptis chinensis, rhizoma picrorhizae, the fruit of Rangoon creeper and liquorice. The Chinese medicinal herb-containing feed additive is 1.5-2wt% of the pig feed, can improve immunity of the weaned pig, prevent weaned pig multisystem failure syndrome, and has the characteristics of cheap price, non-toxic effect and non-side effect.

The invention discloses a preparation method and application of a Chinese magnolcavine fruit volatile oil microcapsule. The preparation method comprises the following steps: taking Chinese magnolcavine fruit volatile oil as a core material, preparing a wall material solution by taking maltodextrin and whey protein as raw materials, then adding a mixed emulsifying agent of monoglyceride and sucrose ester, further adding the core material, emulsifying, homogenizing and performing spray drying to obtain microcapsule particles. According to the preparation method disclosed by the invention, the Chinese magnolcavine fruit volatile oil is wrapped by the polymer material to form the microcapsule, so that the obtained product has relatively good water solubility and stability; pharmacodynamic evaluation proves that the microcapsule has an effect on relieving cough, and the efficacy is above 70% of that of codeine, so that the microcapsule can provide a preferred medicament for treating acute and chronic cough.

The invention provides a liquiritin preparation with the molecular formula of C26H30O13 and the molecular weight of 550. The liquiritin is singly prepared or by matching with other active components or auxiliary materials, and the preparation composition is counted in such a way that 1000 particles contain 40g of liquiritin. The liquiritin preparation has stronger effect for relieving cough and eliminating phlegm, therefore, the preparation can be singly prepared by liquiritin or by the liquiritin matching with other active components or auxiliary materials, can be used for improving symptoms of cough and profuse sputum, and can be applied to the preparation of medicine for curing acute cough, chronic cough and profuse sputum. The liquiritin preparation originates from natural plants, can be made into a health-care product, and provides the natural cough-relieving medicine with less toxic side effect and obvious healing effect for clinical treatment.

The invention provides a food health preserving tea electuary for nourishing yin and moisturizing lung, which belongs to the field of nutritious foods and aims at having a good effect and quickly taking effect. The food health preserving tea electuary is prepared from raw materials such as rhizoma polygonati, prepared rehmannia root, adenophora stricta, fritillaria cirrhosa, soybeans and the like. The food health preserving tea electuary has good effects of reinforcing the vital energy, consolidating the constitution, reinforcing qi, nourishing blood, eliminating phlegm, stopping cough, nourishing yin and moisturizing lung and has the advantages of having a good effect and quickly taking effect.

The invention provides an application of licorice flavonoids in preparing antitussives for treating acute and chronic cough caused by a plurality of reasons. The related acute and chronic cough comprises cough symptoms caused by various diseases such as acute and chronic tracheitis, asthma, chronic obstructive disease of lung, idiopathic pulmonary fibrosis, tuberculosis, bacterial pneumonia, bronchiectasis and the like. The licorice flavonoids extracted from liquorice proves to have very strong effect in preventing cough according to pharmacological tests; drug potency thereof is similar to the drug potency of codein in narcotic antitussive; the function mechanism analyses indicate that the licorice flavonoids plays the role of preventing cough through the non-narcotic nerve centre. In addition, the licorice flavonoids extracted from natural plants can also be prepared into health food. The invention solves the problem that the non-narcotic potent antitussives are badly needed, provides a non-narcotic potent antitussives which has fine social and economical benefits.

The invention discloses a traditional Chinese medicine composition for treating chronic cough and a preparation method thereof. The traditional Chinese medicine composition for treating chronic coughis prepared through the following raw materials: liquorice, rhizoma zingiberis, schisandra chinensis and cartialgenous. The traditional Chinese medicine composition for treating chronic cough is prepared by screening a large number of medical components; recombining; and testing; and the traditional Chinese medicine composition for treating chronic cough is prepared through traditional Chinese medicinal materials, so that a patient is safe to take and does not need antibiotic; the patient avoids antibiotics resistance; the traditional Chinese medicine composition has the functions of eliminating phlegm by cooling, alleviating mental depression, eliminating stagnation, dispelling the wind and relieving a cough, and is capable of strengthening the mechanism of the human body, and improving the immunity and the disease resistance and is outstanding in effect of treating chronic cough.

The invention relates to keratin BD-6, a nucleic acid molecule encoding the keratin BD-6, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or a genome integrating the nucleic acid molecule, a preparation method of the keratin BD-6, and a pharmaceutical composition containing the keratin BD-6. The invention further discloses an application of the keratin BD-6, the nucleic acid molecule, the expression vector, a host cell or the pharmaceutical composition in preparation of antipyretic, analgesic, antitussive, expectorant, anticonvulsant, antiepileptic, antihypertensive, anti-inflammatory and antiviral drugs.

The invention relates to a keratin BD-1, a nucleic acid molecule encoding the keratin BD-1, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or a genome integrating the nucleic acid molecule, a preparation method of the keratin BD-1, and a pharmaceutical composition containing the keratin BD-1. The invention further discloses an application of the keratin BD-1, the nucleic acid molecule, the expression vector, the host cell or the pharmaceutical composition in preparation of antipyretic, analgesic, antitussive, expectorant, anticonvulsant, antiepileptic, antihypertensive, anti-inflammatory and antiviral drugs.

The invention provides a drug composition with the active components of levodropropizine, guaifenesin and pseudoephedrine or acceptable salts on the drugs and a preparation method, which is used for treating nasopharynx mucosa hyperemia, nasal obstruction, sneeze, snivel caused by cold and other diseases, cough and expectoration and other symptoms caused by bronchitis. Compared with the common used centrally antitussive drugs on market, the peripherally antitussive drugs of levodropropizine adopted by the invention have the advantages of obvious antitussive effect and less adverse reaction.

An antiviral and antibacterial Chinese medicine in the form of particle, capsule, tablet, pill, oral liquid syrup, injection, etc for treating upper respiratory tract infection, influenza, bronchitis and tonsillitis is prepared from 4-6 Chinese-medicinal materials including scutellaria root, honeysuckle flower, liquorice root, etc.

The present invention relates to a medicine composition containing zinc gluconate for resisting pneumonia diplococcus. Said medicine composition includes paracetamol, zinc gluconate, isothiazine hydrochloride, isatis root extract, lonicera and others. It can quickly obtain therapeutic effect, and its therapeutic effect is high.

An antiviral and antibacterial Chinese medicine in the form of particle, capsule, tablet, pill, oral liquid syrup, injection, etc for treating upper respiratory tract infection, influenza, bronchitis and tonsillitis is prepared from 4-6 Chinese-medicinal materials including scutellaria root, honeysuckle flower, liquorice root, etc.

The invention relates to a keratin BD-15, a nucleic acid molecule encoding the keratin BD-15, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or a genome integrating the nucleic acid molecule, a preparation method of the keratin BD-15, and a pharmaceutical composition containing the keratin BD-15. The invention further discloses an application of the keratin BD-15, the nucleic acid molecule, the expression vector, the host cell or the pharmaceutical composition in preparation of antipyretic, analgesic, antitussive, expectorant, anticonvulsant, antiepileptic, antihypertensive, anti-inflammatory and antiviral drugs.

The invention provides an application of licorice flavonoids in preparing antitussives for treating acute and chronic cough caused by a plurality of reasons. The related acute and chronic cough comprises cough symptoms caused by various diseases such as acute and chronic tracheitis, asthma, chronic obstructive disease of lung, idiopathic pulmonary fibrosis, tuberculosis, bacterial pneumonia, bronchiectasis and the like. The licorice flavonoids extracted from liquorice proves to have very strong effect in preventing cough according to pharmacological tests; drug potency thereof is similar to the drug potency of codein in narcotic antitussive; the function mechanism analyses indicate that the licorice flavonoids plays the role of preventing cough through the non-narcotic nerve centre. In addition, the licorice flavonoids extracted from natural plants can also be prepared into health food. The invention solves the problem that the non-narcotic potent antitussives are badly needed, provides a non-narcotic potent antitussives which has fine social and economical benefits.

The invention relates to a throat-clearing food health tea granule, and belongs to the field of nutritional foods. The throat-clearing food health tea granule achieves the purposes of good effect and quick effect. The throat-clearing food health tea granule is prepared by adopting raw materials, namely polygonum multiflorum, peack seeds, fructus forsythiae, bulbus fritillariae cirrhosae, and the like. The throat-clearing food health tea granule disclosed by the invention has the effects of strengthening body resistance and culturing vitality, reinforcing qi and nourishing blood, promoting circulation and removing stasis, refreshing larynx and clearing throat and has the advantages of good effect and quick effect.

The invention provides a liquiritin preparation with the molecular formula of C26H30O13 and the molecular weight of 550. The liquiritin is singly prepared or by matching with other active components or auxiliary materials, and the preparation composition is counted in such a way that 1000 particles contain 40g of liquiritin. The liquiritin preparation has stronger effect for relieving cough and eliminating phlegm, therefore, the preparation can be singly prepared by liquiritin or by the liquiritin matching with other active components or auxiliary materials, can be used for improving symptoms of cough and profuse sputum, and can be applied to the preparation of medicine for curing acute cough, chronic cough and profuse sputum. The liquiritin preparation originates from natural plants, can be made into a health-care product, and provides the natural cough-relieving medicine with less toxic side effect and obvious healing effect for clinical treatment.

The invention discloses a Manchurian wildginger total polysaccharide extract with cough-relieving activity and a preparation method and application thereof, belonging to the technical field of medicines. The Manchurian wildginger total polysaccharide extract is prepared by subjecting the root and / or tuber of Manchurian wildginger to extraction with a polar solvent, carrying out ethanol precipitation and then carrying out drying under reduced pressure, wherein the yield and the content of the total polysaccharide are 15 wt% and 60 to 80 wt%, respectively. Through a great number of pharmacodynamic tests, it is proved for the first time that the Manchurian wildginger total polysaccharide extract has a substantial cough inhibiting effect which is close to a treatment effect of codeine and shows a better effect on prolonging the incubation period of cough compared with codeine, and it is found out for the first time that the Manchurian wildginger total polysaccharide extract is capable of reducing sensitivity of cough and inhibiting airway inflammations, has good prevention and treatment effects on a variety of cough and can be used for preparation of drugs used for treating diseases related to cough. The Manchurian wildginger total polysaccharide extract has the advantages of definite activity, usage of original plants as experimental materials and low cost.

The invention discloses application of marmesine in preparation of a cough relieving medicine. According to the invention, marmesine has an obvious cough relieving effect and is found for the first time; furthermore, the cough relieving manner is a non-central cough relieving manner; side effects of conventional central cough relieving medicines in the aspect of a central nervous system are avoided; the invention provides a brand-new selection and idea for current cough treatment, expands selection fields of cough relieving medicines and also makes a contribution to development in the technical field; the marmesine disclosed by the invention is a compound having a definite chemical structure; for pharmacy, the marmesine can be quantitatively fed and is used for preparing modern dosage forms; and furthermore, the marmesine is high in medicine safety and has a potential to develop the cough relieving medicine.

The present invention relates to an indoleacetic acid derivative and a preparation method and pharmaceutical use thereof. In particular, the present invention relates to a compound shown in general formula (I), a preparation method thereof, a pharmaceutical composition comprising the same, and a use thereof as a cough suppressant in treating a disease such as a cough. The definition of each substituent in the general formula (I) is the same as the definition in the specification.

The invention relates to a traditional Chinese medicine for treating asthma disease. The traditional Chinese medicine for treating asthma disease is prepared from the following traditional Chinese medicine materials: 15 to 18 g of white mulberry root bark processed with honey, 4 to 8 g of stir-fried bitter almond, 15 to 20 g of radix angelicae pubescentis, 8 to 12 g of burdock, 8 to 12 g of platycodon grandiflorum and 10 to 12 g of couch grass root. The preparation method comprises the following steps: taking the six kinds of medicines and adding water to perform extraction for 3 times; in thefirst time, adding water in an amount which is 12 times that of the medicines, soaking for 0.5 hour and decocting for 1.5 hours; in the second time, adding water in an amount which is 10 times that of the medicines and decocting for 1.5 hours; in the third time, adding water in an amount which is 10 times that of the medicines and decocting for 1.5 hours; combining the decoction, filtering, concentrating the filtrate until about 600 ml, and filtering; and adding ethanol into the filtrate until the alcohol content reaches 70 percent, stirring uniformly, standing for 12 hours, filtering, recovering ethanol from the filtrate under reduced pressure, adding water in the medicine liquid until 600 ml, stirring uniformly, standing for 12 hours, filtering, adding 100 g of cane sugar, 1 g of citricacid, 2 g of sodium benzoate and 0.5 ml of edible essence, stirring to dissolve the materials, adding distilled water to adjust the total amount to 1000 ml, filtering, filling (10 ml / piece) and sterilizing to obtain the traditional Chinese medicine for treating asthma disease. The traditional Chinese medicine for treating asthma disease has remarkable effects of relieving cough, eliminating phlegm and relieving asthma, and can effectively improve the clinical symptoms of patients.

The invention provides a healthy cigarette with antibacterial, antifungal and antivirus effects and asthma and cough relieving functions to solve the problems in the prior art. The healthy cigarette is characterized by being prepared from various substances in percentage by mass as follows: 99%-99.5% of old folium artemisiae argyi, 0.1%-0.5% of mint, 0.2%-0.3% of strawberry oil, 0.1%-0.3% of flavoring tobacco juice and 0.2%-0.4% of honey.

The invention discloses an asarum total lignan extract and a preparation method and application thereof, belonging to the technical field of medicines. The preparation method comprises the following steps: extracting the root and / or tuber of asarum with a polar solvent and then carrying out concentration and drying so as to obtain an asarum total extract; and dissolving the asarum total extract with water, injecting the dissolved asarum total extract into a macroporous adsorption resin, carrying out gradient elution by using an aqueous ethanol solution, collecting eluate, recovering the solvent and carrying out drying so as to obtain the asarum total lignan extract with a content of 60 to 80 wt%, wherein yield of the asarum total lignan extract is 8.4 wt%. Through a great number of pharmacodynamic tests, it is proved for the first time that the asarum total lignan extract has substantial cough-inhibiting and cough reflex sensitivity-lowering effects which are close to the effects of codeine, and it is found out that the asarum total lignan extract has effects on inhibiting airway inflammations, reducing coughing frequencies and prolonging the incubation period of cough, exerts good prevention and treatment effects on a variety of coughs and can be used for preparation of drugs used for treating diseases related to cough. The asarum total lignan extract has the advantages of definite activity, usage of original plants as experimental materials and low cost.

The invention relates to a keratin BD-2, a nucleic acid molecule encoding the keratin BD-2, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or a genome integrating the nucleic acid molecule, a preparation method of the keratin BD-2, and a pharmaceutical composition containing the keratin BD-2. The invention further discloses an application of the keratin BD-2, the nucleic acid molecule, the expression vector, the host cell or the pharmaceutical composition in preparation of antipyretic, analgesic, antitussive, expectorant, anticonvulsant, antiepileptic, antihypertensive, anti-inflammatory and antiviral drugs.

The invention relates to a keratin BD-4, a nucleic acid molecule encoding the keratin BD-4, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or a genome integrating the nucleic acid molecule, a preparation method of the keratin BD-4, and a pharmaceutical composition containing the keratin BD-4. The invention also discloses an application of the keratin BD-4, the nucleic acid molecule, the expression vector, the host cell or the pharmaceutical composition in preparation of antipyretic, analgesic, antitussive, expectorant, anticonvulsant, antiepileptic, antihypertensive, anti-inflammatory and antiviral drugs.