Application of marmesine in preparation of cough relieving medicine

An antitussive and drug technology, which is applied to the application field of azadirachtin in the preparation of antitussive drugs, can solve the problems of epilepsy, death, unsuitability for long-term use, etc., and achieves the effect of widening the selection field and high safety.

Active Publication Date: 2015-04-08
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of antitussive has a strong effect, but it is not suitable for long-term use because it often has obvious adverse reactions. For example, dextromethorphan can cause brain damage, seizures, loss of consciousness, irregular heartbeat, respiratory depression, and even death. addictive
At present, there is no research report on the antitussive activity of citridin

Method used

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  • Application of marmesine in preparation of cough relieving medicine
  • Application of marmesine in preparation of cough relieving medicine
  • Application of marmesine in preparation of cough relieving medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 The antitussive effect of citric acid on guinea pig cough induced by citric acid

[0019] (1) Materials

[0020] 1. Experimental animals: Hartly guinea pigs, normal grade, half male and half male, 120, weighing 250-350 g, provided by Guangdong Medical Experimental Animal Center, experimental animal license number: SCXK (Guangdong) 2008-0002.

[0021] 2. Reagents and instruments:

[0022] Citric acid solution: take citric acid (product of Guangdong Guanghua Chemical Factory Co., Ltd.) and saline to make a 17.5% solution. Oral gavage needle: customized by the Experimental Animal Center of Guangdong Occupational Health Inspection Center. YLS-8A Cough Inducing Asthma Apparatus: Product of Shandong Medical Science Equipment Station.

[0023] (2) Experimental method

[0024] Take 120 guinea pigs, place them one by one in a 6L spray plastic container, spray 17.5% citric acid solution through a glass nozzle with a pressure of 600mmHg by ultrasonic spray method, an...

Embodiment 2

[0030] Example 2 Antitussive effect of citrus aurantium on guinea pig cough induced by capsaicin

[0031] (1) Materials

[0032] 1. Experimental animals: Hartley guinea pigs, half male and half female, weighing 250-350 g, ordinary grade, provided by Guangdong Medical Experimental Animal Center, animal qualification certificate number: SCXK (Guangdong) 2008-0002.

[0033] 3. Reagents and instruments:

[0034] Capsaicin solution: capsaicin was provided by Hubei Artek Sugar Chemical Co., Ltd., batch number: 20080604. Weigh capsaicin powder before the experiment, and prepare a solution of 3 mg / ml with ethanol: Tween 80: 0.9% normal saline 1: 1: 8 as the mother solution. During the experiment, the mother solution is diluted with 0.9% normal saline 1: 100 , and its final concentration was 30 μg / ml. Oral gavage needle: customized by the Experimental Animal Center of Guangdong Occupational Health Inspection Center.

[0035] (2) Experimental method

[0036] Take 100 guinea pigs, p...

Embodiment 3

[0042] Example 3 The effect of triciferin on electrical stimulation of cat superior laryngeal nerve cough

[0043] (1) Materials

[0044] 1. Experimental animals: 24 domestic cats, half male and half male, weighing 2.0-3.0 kg. Bought from Conghua, Guangzhou.

[0045] 2. Reagents and instruments:

[0046] Chlorose: produced by A Johnson Mathey Company, batch number: 15879-93-3; NaCl: Shantou Guanghua Chemical Factory, AR, batch number: 20051208; biological function experiment system: Chengdu Taimeng Technology, BL-420E; PEG400: Guanghua Chemical Factory Ltd, AR, lot number: 20050423.

[0047] (2) Experimental method

[0048] Domestic cats were taken and randomly divided into three groups: citridin (20, 40 mg / kg), codeine phosphate (6 mg / kg) and a blank control group, with 6 cats in each group, half male and half male. Anesthetized with 1% chloralose 30 mg / kg ip. The dorsal position of the cat was fixed on the operating table, the superior laryngeal nerve was separated, an...

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PUM

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Abstract

The invention discloses application of marmesine in preparation of a cough relieving medicine. According to the invention, marmesine has an obvious cough relieving effect and is found for the first time; furthermore, the cough relieving manner is a non-central cough relieving manner; side effects of conventional central cough relieving medicines in the aspect of a central nervous system are avoided; the invention provides a brand-new selection and idea for current cough treatment, expands selection fields of cough relieving medicines and also makes a contribution to development in the technical field; the marmesine disclosed by the invention is a compound having a definite chemical structure; for pharmacy, the marmesine can be quantitatively fed and is used for preparing modern dosage forms; and furthermore, the marmesine is high in medicine safety and has a potential to develop the cough relieving medicine.

Description

technical field [0001] The invention relates to a new application of aprincipolin, in particular to the application of aprincipin in the preparation of antitussive medicine. Background technique [0002] Respiratory diseases are common and frequently-occurring diseases, and cough is its common clinical symptom. Under normal circumstances, when the respiratory tract is stimulated (such as inflammation, foreign body), various receptors in the respiratory tract convert this stimulus into a nerve impulse, which is transmitted along the afferent nerve to the cough center, and the cough center is stimulated by the impulse. Cough command, which is transmitted to the smooth muscles of the airway, respiratory muscles, and laryngeal muscles through nerves, causing coughing. So coughing is a defensive reflex activity produced when the respiratory system is stimulated. But cough is also a pathological reaction and is one of the most common symptoms of respiratory diseases. Too freque...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/37A61P11/14
Inventor 李沛波苏薇薇王永刚彭维吴忠
Owner SUN YAT SEN UNIV
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