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Asarum total volatile oil extract and its extraction method and its application in the preparation of medicine for treating chronic cough

A technology of chronic cough and extract, which is applied in the field of preparation and treatment of chronic cough medicine, total volatile oil extract of Asarum and its extraction, can solve problems such as not being effectively promoted, not suitable for large-scale industrial production, and large loss of volatile components , to achieve the effect of simple and easy to control, avoid oxidation and pyrolysis, and good product quality

Active Publication Date: 2017-12-05
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Steam distillation and Soxhlet extraction are very commonly used extraction methods, but these two methods have disadvantages such as time-consuming, solvent-consuming, large loss of extracted volatile components, and unstable heating components.
Other methods are relatively new, but there are immature technical equipment and high cost. They have not been effectively promoted and are not suitable for large-scale industrial production.

Method used

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  • Asarum total volatile oil extract and its extraction method and its application in the preparation of medicine for treating chronic cough
  • Asarum total volatile oil extract and its extraction method and its application in the preparation of medicine for treating chronic cough
  • Asarum total volatile oil extract and its extraction method and its application in the preparation of medicine for treating chronic cough

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Preparation and analysis of the total volatile oil extract of Herba Asarum

[0047] 1.1 Preparation of Asarum volatile oil extract

[0048] Using supercritical CO 2 The extraction device extracts the total volatile oil extract of Asarum, washes the root and / or rhizome of Asarum, dries it, and pulverizes it with a pulverizer to obtain coarse powder of Asarum, which is added to the charging bottle of the extraction kettle, and then Put into the extraction kettle, seal; heat, when the temperature of the extraction kettle reaches 50°C, open the valve of the extraction kettle, when the pressure in the extraction kettle is equal to the pressure of the storage tank, open the exhaust valve to discharge the air, pressurize the system, when the extraction When the pressure of the kettle reaches 35Mpa, the separation kettle Ⅰ and the separation kettle Ⅱ reach 5Mpa, and the separation temperature reaches 40°C, control the CO 2 The flow rate is 40L / h, and the circulation extractio...

Embodiment 2

[0055] Acute antitussive effect of total volatile oil extract of Asarum on guinea pig cough induced by citric acid

[0056] 2.1 Experimental materials

[0057] Experimental animals: ordinary Hartley guinea pigs, half male and half male, weighing 250-350 g, provided by Guangdong Medical Experimental Animal Center, animal qualification certificate number: SCXK (Guangdong) 2008-0002.

[0058] Reagents and instruments: citric acid monohydrate (Guangzhou Chemical Reagent Factory, batch number: 20121001-2), prepared into 0.8M physiological saline solution when used; animal non-invasive Buxco pulmonary function testing system (Buxco, USA); Aeroneb Pro nebulizer ( Aerogen (Ireland) Co., Ltd.); gavage needle (Guangdong Medical Experimental Animal Center).

[0059] 2.2 Experimental method

[0060] The drug efficacy was evaluated by citric acid-induced acute cough model in guinea pigs. Take 112 Hartley guinea pigs, place them one by one in the animal non-invasive Buxco pulmonary funct...

Embodiment 3

[0077] Antitussive effect of total volatile oil extract of Asarum on a guinea pig model with increased chronic cough sensitivity

[0078] 3.1 Experimental materials

[0079] Experimental animals: ordinary Hartley guinea pigs, half male and half male, weighing 250-350 g, provided by Guangdong Medical Experimental Animal Center, animal qualification certificate number: SCXK (Guangdong) 2008-0002.

[0080] Reagents and instruments: citric acid monohydrate (Guangzhou Chemical Reagent Factory, batch number: 20121001-2), prepared into 0.8M physiological saline solution when used; animal non-invasive Buxco pulmonary function testing system (Buxco, USA); Aeroneb Pro nebulizer ( Aerogen (Ireland) Co., Ltd.); cell counting plate (Chumen Medical Instrument Factory, Yuhuan County, Zhejiang); intragastric injection needle (Guangdong Medical Experimental Animal Center).

[0081] 3.2 Experimental method

[0082] The qualified animal screening method is the same as that in Example 2. Get 6...

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Abstract

The invention discloses a total volatile oil extractive of asarum, an extraction method of the total volatile oil extractive and an application of the total volatile oil extractive in preparation of drugs for treating chronic coughs, belongs to the field of natural drugs and discloses a total volatile oil extractive of asarum as well as an extraction method and application of the total volatile oil extractive. The method comprises the steps of placing coarse asarum powder into an extraction kettle of a supercritical CO2 extraction device, and sealing; heating, opening a valve of the extraction kettle when the temperature of the extraction kettle is up to 45-70 DEG C, opening a vent valve to empty air and pressurizing a system when the pressure inside the extraction kettle is equal to that of a storage tank, and controlling the flow rate of CO2 at 35-60L / h and beginning to circularly extract when the pressure of the extraction kettle is up to 30-40Mpa, the pressures of a separation kettle I and a separation kettle II are up to 5-10Mpa and the separation temperature is up to 30-50 DEG C; and after extracting for 60-240 minutes, receiving the extracted total volatile oil extractive of asarum from discharging holes of the separation kettles. A great number of pharmacodynamic tests prove that the total volatile oil extractive of asarum has a remarkable effect on treatment of various chronic coughs and can be used for preparing drugs for treating corresponding diseases.

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and more specifically relates to a total volatile oil extract of asarum and its extraction method and its use in preparing medicine for treating chronic cough. Background technique [0002] Cough is a common and frequently-occurring disease of the respiratory system, and is a common complaint in outpatient departments of the respiratory department. Cough itself is a defensive reflex activity produced when the respiratory system is stimulated. It helps to clear the airway of external irritants and its own secretions. It is a beneficial action and is sometimes seen in healthy people. In general, mild and infrequent coughs can be relieved naturally without the use of antitussives, while long-term frequent or intense coughs are a pathological response, which will not only increase the suffering of patients, affect rest and sleep, but also increase Physical exertion, when severe, can also p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C11B9/02A61K36/264A61P11/14C11B9/00
CPCA61K36/268A61K2236/15A61K2236/37C11B9/00
Inventor 赖克方刘晓东钟伯年钟山聂怡初黄楚琴
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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