692 results about "Physiological saline" patented technology

The invention discloses a cervical image classification method and system based on wavelet transform multi-modal fusion, and the method comprises the steps: 1) constructing a multi-branch feature coding network, and respectively processing a cervical OCT image, a colposcope normal saline image, an iodine coating image and an acetic acid white image; 2) introducing wavelet transform to perform frequency domain decomposition on the multi-modal image, obtaining high-frequency and low-frequency components and designing a cross-frequency interaction mechanism to more effectively capture the structure and detail information of the image, and extracting each modal feature through a ResNet-18 backbone network; 3) designing a feature fusion module, performing channel stacking on the three colposcope features, compressing the three colposcope features, and cascading the three colposcope features with the OCT features to form fusion features; (4) feature dimension reduction is achieved through double full connection layers, a weighted voting multi-mode decision classification strategy is adopted, a five-fold cross validation strategy is adopted, and a weighted cross entropy loss function is combined to solve the problem of data imbalance, and (5) finally Softmax classification is carried out.

The invention relates to the related technical field of medical instruments, in particular to a contrast injection device for enhancing nuclear magnetic resonance, which comprises a base, a mounting shell arranged at the upper part of the base, a first barrel arranged at the left upper part in the mounting shell, a second barrel arranged at the right upper part in the mounting shell, and a mixing barrel arranged in the middle of the upper part of the mounting shell, a first piston rod is arranged in the first barrel, a second piston rod is arranged in the second barrel, communicating pipes are respectively communicated between the first barrel and the mixing barrel and between the second barrel and the mixing barrel, a one-way water inlet pipe is arranged at the top of the barrel, and the one-way water inlet pipe is communicated with an external liquid storage tank. By rotating the adjusting screw rod, the adjusting screw rod drives the first wedge-shaped block to move to the position of the needed dosage, then the rodless air cylinder controls the extrusion plate to move upwards, and after the extrusion plate moves upwards and makes contact with the plate body, the piston rods move upwards to inject the contrast agent and normal saline of the corresponding dosage into the mixing barrel to be mixed.

The invention relates to a heparinized gelatin / sodium alginate pancreas islet packaging material with an anti-fibrosis function as well as a preparation method and application of the heparinized gelatin / sodium alginate pancreas islet packaging material. The preparation method comprises the following steps: adding gelatin into normal saline, soaking, performing autoclaved sterilization to obtain a gelatin solution, then adding epsilon-polylysine hydrochloride into the gelatin solution, and finally adding glutamine transaminase for reaction to obtain an epsilon-polylysine grafted gelatin solution; adding heparin into the solution, and reacting to obtain a heparinized gelatin solution; adding sodium alginate and glutamine transaminase, reacting, diluting, preparing hydrogel microspheres by adopting an electrostatic spraying method, and cross-linking to obtain the hydrogel microspheres. According to the invention, heparin molecules are incorporated into a pancreas islet packaging system, so that fibrosis at the periphery of the microspheres can be relieved, the pancreas islet cells are packaged by using the pancreas islet packaging material to prepare the biological artificial pancreas, the pancreas islet cell proliferation and insulin secretion can be promoted, and the pancreas islet packaging material has a good diabetes treatment effect.

The invention discloses a salt-tolerant microbial agent as well as a preparation method and application thereof, and belongs to the technical field of fertilizers. The preparation method comprises the following steps: inoculating a microbial agent into a culture medium for culturing to obtain a bacterial suspension, and collecting thalli; resuspending the thalli by using sterile normal saline to obtain resuspended bacterial liquid; mixing the resuspended bacterial liquid with an embedding liquid to obtain a mixed liquid; dropwise adding the mixed solution into a CaCl2 solution, and curing; and drying to obtain the salt-tolerant microbial agent. The embedding liquid contains 1 to 3g / 100mL of sodium alginate and 1 to 3g / 100mL of polyvinyl alcohol. The influence of a high-salt environment on the microbial agent is isolated by utilizing a physical method, the tolerance of the microbial agent in the high-salt environment is improved, the activity and metabolism efficiency of the microbial agent are improved, and the technical bottleneck of thallus inactivation when a microbial fertilizer and a chemical fertilizer are compounded is solved.

The invention disclosed in this document presents a novel direct in-scope suction system designed for the retrieval of calculus fragments within the body. This system comprises two key components: a calculus fragments retrieval device and a pump unit. The calculus fragments retrieval device features a body with a single working channel that includes both an irrigation port and a suction port, which are connected to respective irrigation and suction pumps via elastomer-based rubber tubes. This setup allows for the controlled infusion of saline solution into the body lumens during lithotripsy procedures, ensuring clear visibility and fragment clearance. The retrieval device includes a trigger lever connected to a pincher tab. When the operator presses the trigger lever, the suction port is opened by releasing the pinched suction tube, increasing pressure inside the body.

The invention discloses a film water collection negative pressure system for an antibacterial operation. The film water collection negative pressure system comprises a water collection main body, a waterproof film and a negative pressure drainage tube. The shape of the water collecting main body is configured to surround a water collecting area on the outer side of a surgical incision on the body surface of a patient, and microporous structures facing the stoma of the human body are distributed on the water collecting main body; the water collecting main body and the water collecting area are covered with the waterproof thin film, the waterproof thin film is provided with a surgical operation opening corresponding to the stoma of the human body in position, and the waterproof thin film is further provided with a liquid passing hole facing the micropore structure; the head end of a tube body of the negative pressure drainage tube is connected with the micropore structure in an attached mode. And the tail end of the tube body of the negative pressure drainage tube is communicated and connected with a negative pressure source. Sterile normal saline for lavage incision can be prevented from flowing to an operating table, a bed sheet and the ground along the body of a patient, the sterile environment of an operation area is guaranteed, the risks of low body temperature, postoperative infection and the like in the operation of the patient are reduced, and the experience of the patient in the perioperative period is improved.

The invention discloses a silk fibroin solution injection capable of forming gel in situ and a preparation method and application thereof.The preparation method comprises the following steps that a regenerated silk fibroin solution with the molecular weight of 100 kDa-250 kDa and a hydrogen bond breaker are evenly mixed to obtain a mixed solution, the mixed solution is subjected to quick-freezing supercooling crystallization and vacuum drying to obtain silk fibroin powder, and the silk fibroin powder is dried to obtain the silk fibroin solution injection capable of forming gel in situ. And sterilizing and dissolving in normal saline to obtain the silk fibroin solution injection. A hydrogen bond breaker is introduced into a high-molecular-weight regenerated silk fibroin solution, a beta folding structure between silk fibroin molecules is inhibited, damage to the silk fibroin molecules in the freeze-drying process is reduced through a quick-freezing and supercooling crystallization method, and aggregation of the silk fibroin molecules is further reduced; after redissolving, an injection is formed and injected into local tissues, the micromolecular hydrogen bond breaker quickly diffuses, and the large molecular weight regenerated silk fibroin recovers hydrogen bond interaction and then forms hydrogel in situ through physical crosslinking, so that in-vivo in-situ gelling of the silk fibroin is realized.

The invention provides a quick replaceable bronchoscope interventional operation robot. The quick replaceable bronchoscope interventional operation robot comprises a base, a bronchoscope structure, a driving device, a first supporting part and a second supporting part, the driving device is fixed on the base, one end of the bronchoscope structure is connected with the driving device, the first supporting part is connected with the bronchoscope structure, one end of the second supporting part is connected with the base, and the other end of the second supporting part is connected with the first supporting part; the bronchoscope structure comprises a bronchoscope which is arranged in a first supporting part in a penetrating manner; the shell is used for opening or closing the bronchoscope structure; a through hole is formed in the shell, is communicated with the bronchoscope and is used for introducing external normal saline into the bronchoscope. The bronchoscope structure is stably supported through the base, the first supporting part and the second supporting part, external normal saline can be introduced into the bronchoscope through the through hole in the shell, the bronchoscope can be flushed in time, it is guaranteed that the visual field of the bronchoscope is clear, and the precision and safety of an operation are improved.

The invention relates to the technical field of medical instruments, in particular to a double-sided anti-fog amplification mouth mirror which comprises a mirror body, a rotary connecting mechanism, a micro-channel cleaning system and a handle assembly. A lens main body is formed by fixing a plane mirror (A surface) and an aspheric magnifying lens (B surface) in a back-to-back manner, and a steering engine drives a central connecting rod to realize quick switching of double functions. The lens body is further provided with a heating anti-fog module, the micro-channel system is integrated in the lens frame, the annular distribution cavity is of a double-layer independent structure, the upper layer is communicated with the inclined spraying holes, normal saline is directionally sprayed for preventing fog and removing dirt, and the surface of the lens body is clear through heating of the heating anti-fog module. And the lower layer is communicated with a suction hole to recycle dirt under negative pressure. The handle is integrated with a control button, a foot switch controls washing / suction separately, and single-hand operation is achieved. The problems of view limitation, mirror surface fogging, pollution and single function are systematically solved, and the diagnosis and treatment efficiency and accuracy are remarkably improved.

The invention belongs to the technical field of medical instrument evaluation, particularly relates to a tendon cross-sectional area measuring device and a tendon cross-sectional area measuring method, and provides the tendon cross-sectional area measuring device and the tendon cross-sectional area measuring method on the basis of a volumetric method and a die forming technology. The long and thin cylindrical measuring cylinder is used for containing normal saline, the pressure sensor is used for measuring the hydraulic pressure change caused by the fact that the tendon is immersed in the normal saline, then the liquid volume change is obtained, and the average cross sectional area of the tendon under the corresponding displacement is obtained based on the displacement of the tendon immersed in the liquid. Further, the minimum point of the tendon cross section area is accurately measured, and a reference is provided for a later tensile test.

The present application relates to the technical field of electrolysis therapeutic instrument, and proposes a kind of free puncture hemorrhoid electrolysis therapeutic instrument, including power supply, for providing conversion electric energy to the therapeutic instrument;Control handle, electrically connected with power supply, and the end is equipped with control display system, for grasping and controlling the size of current output;Therapeutic soft pad: electrically connected with power supply, and its upper surface is covered with medical gauze, and is placed in the lower surface of the thigh of the load end of patient, and the thigh skin is fully contacted with the medical gauze added with physiological saline, to form current loop;Free puncture detection expansion probe mechanism, installed on control handle, for tissue examination of anal part and free puncture contact hemorrhoid part, output micro-current.The beneficial effects of the present application are: no need for acupuncture treatment, can reduce the pain and bleeding of patient during treatment, improve the safety of treatment, and use conveniently, treatment is fast.

The present invention relates to an absorber including a first water absorption layer, and a second water absorption layer laminated on the first water absorption layer, in which the first water absorption layer contains water-absorbent resin particles (I) having a water retention capacity of physiological saline of 32 to 80 g / g and a one-minute value of a lockup height of 1.6 cm or less, and the second water absorption layer contains water-absorbent resin particles (II) having a one-minute value of a lockup height of more than 1.6 cm.

The application provides an application of a motion-induced sweat extract in preparation of a medicine for treating, relieving or preventing depression and / or anxiety, and belongs to the field of biological medicine. Specifically, sweat is induced by making a healthy subject perform aerobic exercise of a specific intensity (such as 60%-80% of maximum heart rate), the sweat is collected and eluted by physiological saline, centrifuged and filtered to obtain a biologically active sweat extract. The extract is analyzed by transcriptomics and reverse transcription method to predict the anti-depression potential, and it is proved by in-vivo animal experiments that the extract can significantly improve the anhedonia, behavioral despair and anxiety-like behavior of a depression model mouse, and the effect of a high dose is equivalent to that of a first-line drug fluoxetine. The preparation raw material provided by the application is natural and safe, the preparation process is simple and the cost is low, and a new, easy-to-promote alternative strategy is provided for the prevention and treatment of depression.

The application discloses a general surgery operation trauma nursing device and belongs to the technical field of medical devices, which comprises a body, and a separation component is arranged on the inside and outside of an operating table, wherein the separation component comprises a collecting frame which is inserted into the operating table, a scraping ring is fixedly connected to the inside of the collecting frame, a protective cover is arranged in the operating table, and a driving motor is arranged in the protective cover. The magnetic block ring is arranged to adsorb metal foreign matters, and the rotating disc accelerates the flow of liquid after rotation, so that the foreign matters and necrotic tissues are quickly separated. Since the magnet ring can adsorb the metal foreign matters during rotation, the foreign matters and necrotic tissues are separated, the foreign matters carrying the necrotic tissues are prevented from sinking into the physiological saline and being difficult to separate, and the rotating disc only accelerates the flow speed of the physiological saline during stirring of the physiological saline, so that the over-dissolution of the necrotic tissues is reduced, and the separation effect of the foreign matters and the necrotic tissues is guaranteed.

The invention discloses a preparation method of a boiling antigen for vibrio parahaemolyticus serum agglutination. The preparation method comprises the following steps: selecting common serotype vibrio parahaemolyticus in monitoring for resuscitation; scraping a ring of placenta by using 10 mu L of an inoculating loop, dissolving the placenta in 1 mL of normal saline to prepare a bacterial suspension, and preparing 3 tubes of bacterial suspensions from each strain; boiling the bacterial suspension in boiling water for 1 hour, 45 minutes and 30 minutes respectively; and after boiling, centrifuging at 10000 rpm for 10 minutes, discarding the supernate, and reserving the precipitate as a boiling antigen for serum agglutination. The result shows that the agglutination accuracy after boiling for 1 hour is 100%, and the agglutination degree is 2 + or above; and no significant difference exists between 45 minutes of boiling and 1 hour of boiling, and no significant difference exists between 30 minutes of boiling. Compared with a high-pressure method, the method has the advantages that the operation time is shortened by 2-3 hours, special equipment certificates are not needed, and the method is suitable for daily detection and food poisoning traceability.

The application discloses a kind of consumable conveying devices, comprising: guide wire conveying unit, guide wire is contained in guide wire coil and passes between the pair of guide wire guide wheels, with the rotation of guide wire guide wheel, guide wire is driven forward or backward to retreat;And catheter / stent conveying unit, catheter / stent is contained in catheter / stent coil and passes between the pair of catheter / stent guide wheels, with the rotation of catheter / stent guide wheel, catheter / stent is driven forward or backward to retreat;Wherein the proximal end of guide wire coil is provided with guide wire wetting section, at guide wire wetting section, the upper end side wall of guide wire coil is provided with drop opening, heparin or physiological saline is dropped through drop opening, to wet guide wire in guide wire coil.The application conveys guide wire, catheter / stent and other medical instruments by conveying device, improves the efficiency of guide wire, catheter or stent into human body, reduces the pollution in the preoperative preparation process of guide wire, catheter or stent, and then simplifies the operation of doctor.

Provided in the present invention is a coronary sinus balloon counterpulsation catheter, comprising a catheter body and a balloon. The catheter body is provided with a first channel and a second channel that extend through the catheter body along the axial direction thereof. The first channel is eccentric to the catheter body. A cross-section of the second channel comprises a first contour line and a second contour line. The first contour line is at least a part of a first circle. The second contour line is at least a part of a second circle. The first contour line is closer to the first channel than the second contour line, and concave sides of the first contour line and the second contour line both face the first channel. The width of the second channel satisfies a predetermined relationship. The balloon is in sealed connection with a distal outer peripheral surface of the catheter body and is in communication with the second channel. The arrangement mode of the first channel and the second channel enables a filling liquid flowing in the second channel to have a relatively low resistance and a relatively high flow rate. In this way, the coronary sinus balloon counterpulsation catheter can use a liquid such as normal saline instead of a gas as a filling medium, thereby avoiding the occurrence of air embolism caused by balloon rupture and improving the safety of use.

The invention provides a hydrogen-containing normal saline high-tightness vacuum hydrogen locking packaging preparation method, which belongs to the technical field of medical liquid packaging, and comprises the following steps: pressurizing prepared hydrogen by using a hydrogen booster pump so as to store high-pressure hydrogen; high-pressure hydrogen is rapidly filled into the high-pressure pressure tank to permeate into the single bottle of normal saline, the residual hydrogen is recycled for cyclic utilization, bottled hydrogen-containing normal saline is obtained and put into a composite aluminum foil bag to be subjected to vacuumizing treatment and heat sealing treatment, a high-sealing-performance vacuum hydrogen locking aluminum foil bag packaging piece is obtained, and a finished product is detected. And quickly freezing qualified products, and refrigerating and storing the qualified products to complete hydrogen locking preparation. High-pressure hydrogen permeates into a single bottle of normal saline, the traditional hydrogen permeation period of several hours is shortened to dozens of seconds, the composite aluminum foil bag is vacuumized and subjected to heat sealing treatment, hydrogen escape is effectively inhibited, the quality guarantee effect is remarkable, the process operation is simple, the hydrogen is recycled, the cost is saved, and the method is suitable for mass production.

The invention relates to the technical field of heme purification, in particular to a heme extraction and purification method. Comprising the following steps: taking fresh animal blood, centrifugally collecting lower red blood cell precipitate, adding normal saline, uniformly mixing and washing; adding an ethanol solution with the concentration of 1-10%, uniformly mixing, and ultrasonically crushing for 15-60 seconds under the power of 300-800W to obtain erythrocyte crushing liquid; adding an acidic acetone solution into the erythrocyte crushing liquid, uniformly mixing, extracting at normal temperature, centrifuging, and collecting supernate to obtain an acidic acetone extracting solution; slowly adding a NaOH solution to adjust the pH value; adding sodium acetate, stirring, standing, taking precipitate, washing and drying to obtain a crude product; filling a silica gel column; loading the crude product, eluting with an eluent, and collecting an elution component containing a target product; the eluent comprises dichloromethane, methanol and formic acid; and removing the mobile phase in the elution component. The method has the advantages of simple process, low cost, environmental friendliness and capability of obtaining a high-purity product.

This invention provides a transcervical access system for moving fluids transcervically. [Solution] The transcervical access system 100 is effective in transferring a wide range of fluids into the uterine cavity, including the delivery of a hydrogel precursor, saline solution, and imaging fluid. The transcervical access system 100 is also effective in removing fluids, such as residual bodily fluids, residual fluids from procedures, or tissue from the uterine cavity. The transcervical access system 100 includes a flow limiter, such as an outflow limiter 106 and / or a cervical plug. A method of using the transcervical access system 100 involves using the transcervical access system 100 to transcervically access the uterine cavity and to install the hydrogel. The transcervical access system 100 and related methods are useful in preventing adhesions after intrauterine procedures by providing a biodegradable hydrogel within the uterine cavity, including the cervix.

The invention discloses a responsive drug-loaded polysaccharide / collagen polypeptide GTR sustained-release membrane and a preparation method thereof, and belongs to the technical field of oral biological materials. The preparation method comprises the following steps: oxidizing polysaccharide to prepare an oxidized polysaccharide solution; the oxidized polysaccharide is subjected to imidazole and cholesterol group grafting modification, antibacterial and anti-inflammatory drugs are loaded, and responsive drug-loaded nanoparticles are prepared; dissolving the determinated collagen polypeptide in normal saline to prepare a collagen polypeptide solution; and uniformly mixing the collagen polypeptide solution, the oxidized polysaccharide solution and the responsive drug-loaded polysaccharide nanoparticles to prepare the responsive drug-loaded polysaccharide / collagen polypeptide GTR sustained-release membrane. According to the invention, safe and nontoxic oxidized polysaccharide rich in carboxyl and aldehyde is used as a cross-linking agent, and responsive polysaccharide nanoparticles are introduced. The polysaccharide / collagen polypeptide GTR sustained-release membrane prepared by the invention has good biocompatibility, mechanical property, degradation property and long-acting response drug release capability, and can be applied to antibacterial treatment of periodontitis.

The invention provides a small-cavity surgical robot with an anti-blocking mechanism, and relates to the technical field of surgical robotics.The small-cavity surgical robot comprises a mechanical arm, an operation platform is rotationally installed on the mechanical arm, an operation instrument used for conducting an operation on a patient is arranged on the operation platform, and a fixing frame is fixedly installed on the operation platform; a circular space between the inner pipe and the outer pipe is divided into two independent areas, the two independent areas are matched with the two connecting pipelines on the outer pipe and the connected micro peristaltic pump, and therefore the inner pipe and the outer pipe can be separated into two independent areas. By means of the design, normal saline and a low-concentration heparin solution can be conveyed respectively, the washing requirement in a conventional operation is met, anticoagulation treatment can be provided for an operation scene with the high blood coagulation risk, the application range of the surgical robot is greatly widened, surgical operation is more targeted and flexible, and the surgical robot is suitable for being popularized and used. And individual differences of different patients can be effectively handled.

The invention discloses a contrast agent filtering device for coronary surgery and a using method thereof, the device is integrally in a plastic bag shape and comprises a filtering bag body, the bottom of the filtering bag body is provided with a transfusion connector and a blood transfusion connector which are provided with sealing covers, and an inner opening is sleeved with a filter screen support with a filter screen; the filter bag body is divided into a filter area and an adsorption particle storage area through a middle seal, a flushing connector and a hanging hole are arranged at the top, and the filter bag body can be matched with a vibration disc for use. The use method comprises the steps that blood containing a contrast agent is extracted and input into the filtering area, the middle seal is opened through pressing, the blood makes full contact with the adsorption particles through vibration or manual extrusion so as to adsorb the contrast agent, then the filtered blood is infused back, and residual plasma can be infused back after being diluted with normal saline. The device is simple in structure, low in cost and easy and convenient to operate, the filtering effect is improved by 30% compared with the prior art, the adsorption rate reaches 75%-85%, contrast agents in blood can be effectively removed, damage to the kidney of a patient is reduced, and the device is particularly suitable for blood treatment of the patient after coronary angiography.

The application discloses a fabric yellowing reagent and a fabric yellowing method, and relates to the technical field of daily chemical products. 5 The fabric yellowing reagent comprises 1-3% of histidine solution and a bacterial suspension with a bacterial concentration of 1*10 5 CFU / mL-9*10 The bacteria are a mixture of one or more of Staphylococcus epidermidis and Micrococcus luteus; the solvent of the histidine solution is normal saline containing 0.15-1% of trypsin peptone; and the solvent of the bacterial suspension is normal saline containing 0.1-0.2% of trypsin soybean peptone liquid culture medium. The fabric yellowing reagent can be used for simulating fabric yellowing, and has good operability, reproducibility and data reliability.

The invention discloses an anaerobic denitrifying bacterial agent as well as a preparation method and application thereof, and belongs to the technical field of water environment treatment. The anaerobic denitrifying bacterium agent is prepared from the following components in parts by weight: 15 to 30 parts of sterile water, 15 to 60 parts of normal saline, 5 to 10 parts of micro-capsule embedded anaerobic denitrifying bacteria, 5 to 20 parts of a porous composite modified carrier, 10 to 30 parts of a carbon source, 4 to 7 parts of nutrient elements, 2.5 to 4 parts of a buffering agent and 1 to 5 parts of a stabilizer, the micro-capsule embedded anaerobic denitrifying bacteria are obtained by embedding anaerobic denitrifying bacteria with an alginic acid gel solution and a calcium chloride solution; the porous composite modified carrier is obtained by crosslinking modified nano iron oxide, modified nano titanium dioxide, a functional polymer solution and glutaraldehyde. The anaerobic denitrifying bacterial agent provided by the invention can effectively improve the efficiency of treating nitrogen pollution of a water body.

The utility model discloses a kind of endoscope surgery pasting film, it is related to medical supplies technical field, including first film, second film, water baffle and liquid collecting and guiding bag.The bottom surface of first film is used to paste on skin.Second film is located on the top surface of first film, and the accommodating cavity that is formed with upward protrusion between second film and first film.Water baffle is located in accommodating cavity, and the region formed by surrounding water baffle is used to accommodate liquid.Liquid collecting and guiding bag is connected with one side of second film, and the bag opening of liquid collecting and guiding bag is towards the opening of water baffle, so that the liquid in the region formed by surrounding water baffle can flow into liquid collecting and guiding bag.In the process of operation by doctor, water baffle can be resisted by second film with physiological saline and patient's blood and other liquids, that is, water baffle plays a blocking role to liquid, so that liquid in the process of operation all stays in the region formed by surrounding water baffle, avoid the pollution of the surrounding environment of operation area.

The application provides a preparation method of polysaccharide vaccine diluent and application to chicken newcastle disease vaccine, and belongs to the technical field of biopharmacy.The application provides a south five canes polysaccharide vaccine diluent and a preparation method thereof, and solves the problems of low uniformity of antibody titer, stress reaction and allergic reaction of the body after inoculation, and influence on the immunization effect of the vaccine caused by the physiological saline or the phosphate buffer solution diluent for diluting the vaccine.The south five canes polysaccharide vaccine diluent can be applied to animal vaccines, including chicken newcastle disease vaccine, and solves the problem that there is no polysaccharide diluent for the chicken newcastle disease vaccine in the prior art.

The utility model discloses a fester drainage and removal device, which belongs to the technical field of medical instruments and comprises an injector, a cleaning and drainage component for cleaning, draining and removing fester and a rotary fixing component for adhering and fixing the cleaning and drainage component. The cleaning drainage assembly comprises a double-channel cleaning assembly and a negative pressure drainage assembly, the double-channel cleaning assembly is installed on the right side of the injector, the negative pressure drainage assembly is installed on the right side of the double-channel cleaning assembly, and the rotary fixing assembly is installed on the left side of the negative pressure drainage assembly. After the double-channel cleaning assembly and the negative pressure drainage assembly are inserted into an esophageal anastomosis fistula, the rotary fixing assembly is attached to the neck, meanwhile, the negative pressure drainage assembly is rotationally fixed, and falling is prevented; the syringe extracts and injects normal saline through pipeline switching of the double-channel cleaning assembly, the negative pressure drainage assembly drains out the normal saline and pus after cleaning through negative pressure and collects the normal saline and the pus, and effective cleaning of the flaccid stoma is achieved.

The present invention discloses a method for determining the content of organic acid metabolites of black plum in colon tissue and its application. The determination method comprises the following steps: (1) adding sterile physiological saline to the colon tissue, grinding, adding methanol to continue grinding, centrifuging, collecting the supernatant, adding methanol and vortexing, centrifuging, and finally adding water and vortexing to obtain a sample solution to be tested; (2) using high performance liquid chromatography-mass spectrometry to draw standard curves of the three organic acids using citric acid, malic acid, and quinic acid standards, wherein citric acid is used in positive ion mode, and malic acid and quinic acid are used in negative ion mode; (3) using the same method to detect the sample to be tested, and the concentration or content of the three organic acid metabolites (citric acid, malic acid, and quinic acid) can be calculated based on the standard curve. The method of the present invention is simple and highly sensitive and can be used to study the mechanism of the effect of black plum on ulcerative colitis.

The utility model relates to the technical field of liquid medicine split charging, and solves the problems that in the split charging process of normal saline, a split charging container is not easy to fix by personnel, so that the fixing effect of the split charging container is poor, the position of the split charging container is easy to incline, and the split charging effect of the split charging container is influenced. The closed guiding-out device comprises a fixing plate, fixing blocks are fixedly installed on the two sides of the top face of the fixing plate, a supporting rod is fixedly installed in the middle of the top face of each fixing block, the other end of each supporting rod is fixedly connected to a top plate, and a positioning assembly is fixedly installed on the surface of each supporting rod. The positioning assembly comprises a connecting plate fixedly connected to the surface of the supporting rod, a threaded rod penetrates through the middle of the surface of the connecting plate in a threaded mode, one end of the threaded rod is rotationally connected with a semi-arc plate, a circular groove is formed in the middle of the top face of the top plate, and an irrigation pipe is inserted into the inner bottom wall of the circular groove.