5 results about "Tissue glue" patented technology

The present application relates to the field of medical tissue adhesive, in particular to a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The present application provides a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The medical tissue adhesive provided by the present application comprises: 1wt%-30wt% of acidic polyglutamic acid; 1wt%-30wt% of spherical protein; and the balance of water. The medical tissue adhesive provided by the present application has high tissue adhesion strength and fast hemostatic sealing speed in a wet physiological environment, meets the requirements of rapid and efficient tissue hemostatic sealing, and can be applied to rapid hemostasis of tissue wounds in a wet physiological environment, sealing of wound liquid leakage, healing and repair of wound tissue, and antibacterial of wounds. Experiments show that the dry adhesive patch made of the adhesive provided by the present application has high tissue adhesion strength in a wet physiological environment, and the adhesion strength to a wet pigskin tissue can reach more than 60kPa.

The application discloses a medical tissue glue modified formula and injection method for treating esophageal varices, and relates to the field of tissue glue; the medical tissue glue modified formula and injection method for treating esophageal varices introduce polyoxyl glycol as a modifier, not only reduce the brittleness and hardness of n-butyl alpha-cyanoacrylate after polymerization, make the formed vascular embolus more flexible, significantly reduce the cutting risk of traditional hard glue block to thin-walled mucosa, thereby reduce the incidence of postoperative glue leakage ulcer and rebleeding; at the same time, polyoxyl glycol itself as a hardener can synergistically damage the vascular endothelium, accelerate thrombosis and vascular fibrosis, and improve the long-term occlusion effect; secondly, the addition of dragon's blood extract or nano-silver and other antibacterial components in the formula can actively inhibit local bacterial colonization, effectively reduce the risk of postoperative sepsis for the clinical pain points of low immunity and easy infection of patients with cirrhosis.

The present invention relates to a radionuclide dosage regimen for the treatment of gastrointestinal cancer (e.g., hepatocellular carcinoma (HCC)) by brachytherapy employing a two-component surgical sealant and / or adhesive (e.g., tissue glue) and radioisotope-loaded microspheres. The effective dosage range of administration is 0.4-220 MBq, and the specific dosage depends on the size of a target tumor.

The invention discloses a mesoscopic phase enhanced polyphenol-based aggregate adhesive and a preparation method thereof, and relates to the technical field of medical tissue adhesives. The preparation method of the adhesive comprises the following steps: step 1, preparing a polyphenol compound into a solution A; 2, preparing an epoxy group high polymer material into a solution B; 3, diluting a silanization reagent with acidic deionized water to obtain a solution C; and 4, mixing the solution B and the solution C, adding the obtained mixture into the solution A, and carrying out oscillation centrifugation to obtain the mesoscopic phase enhanced polyphenol-based aggregate adhesive. According to the preparation method, an organic-inorganic hybrid composite phase body with a mesoscopic phase structure is assembled around an epoxy polymer material phase after being hydrolyzed by a silanization reagent, so that the hydrogen bond and hydrophobic interaction between the epoxy polymer material phase and a polyphenol compound are enhanced. The prepared adhesive has high adhesion on the tissue surface while having the aim of being degradable, and can be used as a good medical tissue adhesive.