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17 results about "Tissue glue" patented technology
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Tissue Adhesive Glue. Tissue adhesive glue has been a revolutionary step in the management of lacerations. Tissue glue is indicated for low tension wounds, or occasionally higher tension wounds that have been properly undermined and layered.
Polyphenol-based tissue adhesive for promoting wound healing and preparation method thereof
The invention discloses a polyphenol-based tissue adhesive for promoting wound healing and a preparation method thereof, and relates to the technical field of medical tissue adhesives. The preparation method of the tissue adhesive comprises the following steps: step 1, preparing a polyphenol compound and recombinant mussel mucin into a solution, and uniformly stirring for later use, namely a solution A; 2, preparing a temperature response type high polymer material into a solution for later use, namely a solution B; and 3, mixing the solution A prepared in the step 1 and the solution B prepared in the step 2, fully and uniformly mixing, shaking and centrifuging, and discarding the supernatant. By selecting the temperature response type high polymer material, the tissue adhesive is endowed with the characteristic of temperature sensitivity, so that the modulus of the adhesive at the human body temperature is improved, and the colloid contraction can further promote wound closure. The mussel mucin is introduced to stimulate collagen regeneration of the wound part, activate the immune mechanism and remodel the wound microenvironment so as to achieve the purpose of promoting healing.
Owner:CHANGZHOU TAICHU BIOTECHNOLOGY CO LTD
Medical tissue adhesive, medical tissue dry adhesive patch and preparation method and application thereof
ActiveCN116617444BSurgical adhesivesPharmaceutical delivery mechanismAdhesion strengthAnti bacterial
The present application relates to the field of medical tissue adhesive, in particular to a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The present application provides a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The medical tissue adhesive provided by the present application comprises: 1wt%-30wt% of acidic polyglutamic acid; 1wt%-30wt% of spherical protein; and the balance of water. The medical tissue adhesive provided by the present application has high tissue adhesion strength and fast hemostatic sealing speed in a wet physiological environment, meets the requirements of rapid and efficient tissue hemostatic sealing, and can be applied to rapid hemostasis of tissue wounds in a wet physiological environment, sealing of wound liquid leakage, healing and repair of wound tissue, and antibacterial of wounds. Experiments show that the dry adhesive patch made of the adhesive provided by the present application has high tissue adhesion strength in a wet physiological environment, and the adhesion strength to a wet pigskin tissue can reach more than 60kPa.
Owner:CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES
Tissue glue application device
The present disclosure provides a tissue glue application device, which includes: two injection assemblies and a mixer; the two injection assemblies are connected to the mixer through an injection port; each injection assembly includes: an injection shell, a slide column and a push rod; the slide column is inserted into the injection shell from the opening and can slide along the injection shell; the two ends of the slide column are respectively an insertion end and a push-pull end; the insertion end is located in the injection shell, and the push rod is installed on the push-pull end; a liquid inlet hole is provided on the insertion end; a plug for sealing the liquid inlet hole is provided on the push rod; the push rod slides relative to the cavity so that the plug opens the liquid inlet hole and the injection shell and the cavity are connected through the liquid inlet hole. The present disclosure uses two injection assemblies to respectively store a variety of tissue glue raw materials, and can use the sliding action of the push rod to open the liquid inlet hole to mix the powder with the liquid to generate tissue glue, thereby facilitating the immediate production and use of tissue glue, and achieving the advantages of sufficient mixing and reaction of the liquid levels and rapid application.
Owner:BEIJING BIOSIS HEALING BIOLOGICAL TECH CO LTD
Instant-adhesive strong-tough wet tissue tape and preparation method thereof
The present invention discloses an instant-adhesive strong-tough wet tissue tape and a preparation method thereof. The preparation of the instant-adhesive strong-tough wet tissue tape comprises the following steps: S1, reacting 3,4-dihydroxyphenylacetic acid with glycidyl methacrylate to synthesize 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate; S2, dissolving chitosan in an acrylic acid aqueous solution, then adding 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate and a photoinitiator to obtain a mixed solution; S3, applying the mixed solution to the surface of a polymer film treated with a plasma cleaner, and then curing under ultraviolet light to obtain the instant-adhesive strong-tough wet tissue tape. This invention designs and synthesizes novel catechol compounds with long alkyl side chains and uses them to manufacture an instantly adhesive, strong, and resilient wet tissue tape. This tape is thin, flexible, and optically transparent, conforming to various substrates and allowing visual inspection of the substrate's state. Prior to use, the tape is dry and non-sticky, but upon contact with water or blood, it rapidly bonds to wet biological tissue. The tape exhibits exceptionally strong interfacial toughness and adhesion strength to wet biological tissue, far exceeding existing commercial adhesives and some other wet tissue adhesives. Therefore, the instantly adhesive, strong, and resilient wet tissue tape can be used for wound closure and hemostasis.
Owner:FUJIAN NORMAL UNIV
A non-invasive cervical cancer orthotopic model modeling method of mice
The present application relates to in situ model modeling method, especially for a kind of non-invasive cervical cancer in situ model modeling method of mouse, including selecting several 8 weeks old BALB / c-nude mouse, all mice are divided into non-invasive group and operation group, the age, weight of two groups of mice are compared, and there is no statistically significant difference;Non-invasive group is widened with the cotton stick of diameter 3mm and wipes dry vagina, the tumor block with luciferase fluorescence is immersed in modified hydrogel, after heating and making modified hydrogel solidification, the tissue glue mixed with hard gypsum in modified hydrogel is dropped on the surface of modified hydrogel and quickly inserted into vagina, when there is obstruction, stop deepening, pause 30s and wait for tissue glue to be completely dry, when tumor block is fixed in cervix, it is modeling completion;Operation group first opens abdominal cavity, and tumor tissue of same size is sutured on cervix.This kind of non-invasive cervical cancer in situ model modeling method of mouse, using non-invasive method to replace operation method to establish non-invasive cervical cancer in situ model, can reduce the pain of mouse, reduce experimental difficulty.
Owner:SHANGHAI RES CENT FOR MODEL ORGANISMS
A biomimetic medical tissue adhesive and a preparation method thereof
The application relates to the technical field of medical materials, and particularly discloses a kind of bionic medical tissue adhesive and a preparation method thereof.A kind of bionic medical tissue adhesive is made of raw materials containing the following weight parts: alpha-cyano octyl acrylate 30-35 parts;degradable polymer material 20-30 parts;gelatin 1-5 parts;polyethylene glycol 2-5 parts;sterile water 20-30 parts;sodium alginate 2-4 parts;antibacterial agent 8-10 parts;stabilizing protective agent 1-3 parts;mussel extract 1-3 parts;slug extract 1-3 parts;its preparation method is: polyethylene glycol, sterile water, sodium alginate, antibacterial agent, stabilizing protective agent, mussel extract and slug extract are mixed, and stirred uniformly;then alpha-cyano octyl acrylate, degradable polymer material and gelatin are added, heated to 40-60 DEG C and stirred for 20-40 min, and the bionic medical tissue adhesive can be obtained.The bionic medical tissue adhesive of the application can better handle the skin tissue changes occurring in the proliferation period, so that the prominence of the scar formed in the later period is smaller, the whole is relatively flat and smooth, and thus the scar is greatly improved.
Owner:SHANGHAI JIAXIN BIOTECHNOLOGY CO LTD
Positive pressure injection needle
The utility model discloses a positive pressure injection needle, and particularly relates to the technical field of injection needles, which comprises a confluence cylinder, a circulation cavity is arranged in the confluence cylinder, a sealing cover is arranged at the upper end of the confluence cylinder, a connecting nozzle is mounted at the lower end of the confluence cylinder, and an injection needle is mounted at the lower end of the connecting nozzle. According to the injection needle, the positive pressure state of an inner cavity is guaranteed through the check valves, the problems that most of the tail portions of existing injection needles are communicated with the atmosphere, the tail portions of the existing injection needles are not communicated with the atmosphere, and the tail portions of the existing injection needles are not communicated with the atmosphere are solved. At the moment when the needle point punctures into the varicose vein, blood in a blood vessel with higher pressure quickly flows back into the front end of the injection needle, and an operator needs to inject tissue glue after exhausting, so that the time is prolonged, and the problem that the blood and the tissue glue are easily solidified instantly is solved.
Owner:THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
Application of alpha-n-butyl cyanoacrylate tissue glue in treatment of diverticulum in digestive tract
The invention discloses application of alpha-cyanoacrylate n-butyl ester tissue glue in treatment of diverticulum of digestive tract. The tissue glue is used for preparing a medicine for treating the diverticulum of the digestive tract; during treatment, the diverticulum is injected through an endoscope, tissue glue makes contact with tissue fluid to be rapidly polymerized, the diverticulum is sealed, diverticulum complications are prevented, biocompatibility is good, degradation is achieved, no residues exist, the treatment effective rate is 100%, no complications exist, and the recurrence rate is low.
Owner:AFFILIATED HOSPITAL OF NANTONG UNIV
Improved formulation of medical tissue glue for treatment of esophageal varices and injection method
The application discloses a medical tissue glue modified formula and injection method for treating esophageal varices, and relates to the field of tissue glue; the medical tissue glue modified formula and injection method for treating esophageal varices introduce polyoxyl glycol as a modifier, not only reduce the brittleness and hardness of n-butyl alpha-cyanoacrylate after polymerization, make the formed vascular embolus more flexible, significantly reduce the cutting risk of traditional hard glue block to thin-walled mucosa, thereby reduce the incidence of postoperative glue leakage ulcer and rebleeding; at the same time, polyoxyl glycol itself as a hardener can synergistically damage the vascular endothelium, accelerate thrombosis and vascular fibrosis, and improve the long-term occlusion effect; secondly, the addition of dragon's blood extract or nano-silver and other antibacterial components in the formula can actively inhibit local bacterial colonization, effectively reduce the risk of postoperative sepsis for the clinical pain points of low immunity and easy infection of patients with cirrhosis.
Owner:徐婷
Compositions, devices and kits for selective internal radiation therapy of hepatocellular carcinoma
The present invention relates to a radionuclide dosage regimen for the treatment of gastrointestinal cancer (e.g., hepatocellular carcinoma (HCC)) by brachytherapy employing a two-component surgical sealant and / or adhesive (e.g., tissue glue) and radioisotope-loaded microspheres. The effective dosage range of administration is 0.4-220 MBq, and the specific dosage depends on the size of a target tumor.
Owner:BETAGLU THERAPEUTICS AG
Mesoscopic phase enhanced polyphenol-based aggregate adhesive and preparation method thereof
The invention discloses a mesoscopic phase enhanced polyphenol-based aggregate adhesive and a preparation method thereof, and relates to the technical field of medical tissue adhesives. The preparation method of the adhesive comprises the following steps: step 1, preparing a polyphenol compound into a solution A; 2, preparing an epoxy group high polymer material into a solution B; 3, diluting a silanization reagent with acidic deionized water to obtain a solution C; and 4, mixing the solution B and the solution C, adding the obtained mixture into the solution A, and carrying out oscillation centrifugation to obtain the mesoscopic phase enhanced polyphenol-based aggregate adhesive. According to the preparation method, an organic-inorganic hybrid composite phase body with a mesoscopic phase structure is assembled around an epoxy polymer material phase after being hydrolyzed by a silanization reagent, so that the hydrogen bond and hydrophobic interaction between the epoxy polymer material phase and a polyphenol compound are enhanced. The prepared adhesive has high adhesion on the tissue surface while having the aim of being degradable, and can be used as a good medical tissue adhesive.
Owner:SOUTH CHINA UNIV OF TECH
Medical tissue glue for pancreas plugging as well as preparation method and application of medical tissue glue
The invention relates to medical tissue glue for pancreas plugging as well as a preparation method and application of the medical tissue glue. The medical tissue glue composition for forming the medical tissue glue disclosed by the invention comprises a medical tissue glue component and a chelating agent component, wherein the medical tissue glue component comprises a first component and a second component, and the first component comprises four-arm polyethylene glycol amine; the second component is prepared from four arm-polyethylene glycol-succinimide glutaric acid ester; wherein m and n are natural numbers; the chelating agent component comprises polyphenol. The medical tissue glue prepared from the medical tissue glue composition disclosed by the invention can be firmly adhered to the surface of pancreatic tissue and can bear dynamic pressure of pancreatic juice leakage and enzymatic degradation activity of pancreatic juice, and more importantly, the medical tissue glue disclosed by the invention has excellent antibacterial ability and can prevent infection caused by long-term accumulation of pancreatic juice leakage.
Owner:BEIJING BIOSIS HEALING BIOLOGICAL TECH CO LTD
Mechanical grabbing structure with adjusting structure for wet tissue glue spraying
Owner:GUANGZHOU BAIHUA DAILY NECESSITIES CO LTD
Tissue adhesive and its preparation method and application
The present invention relates to the field of medical material technology, and specifically provides a method for preparing a tissue adhesive. The preparation method of the present invention comprises: (1) mixing an amino acid raw material, acrylic acid, a cross-linking agent, a solvent and an initiator, and obtaining a tissue adhesive precursor through a polymerization reaction; (2) mixing the tissue adhesive precursor and a polybasic amino acid to obtain a tissue adhesive; the amino acid raw material comprises an acidic amino acid and / or a polyacidic amino acid; and the cross-linking agent is prepared by reacting a glycidyl acrylate compound and a polyacidic amino acid. The present invention uses a double-bond modified polyacidic amino acid as a macromolecular cross-linking agent, and realizes a stable covalent single network structure through free radical copolymerization with an acrylic acid monomer, and then forms hydrogen bonds and electrostatic interactions with the polybasic amino acid to obtain a reinforced and toughened non-covalent network, thereby realizing a double-network reinforced tissue adhesive network structure, which effectively improves the anti-swelling performance of the tissue adhesive.
Owner:CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES
High-performance degradable biomedical tissue adhesive and preparation method and application thereof
Owner:SICHUAN UNIV +1
K-type cross-shaped two-way connector for sclerotherapy of esophageal and gastric fundus varicose veins
The utility model discloses a K type cross two-way interface for hardening treatment of esophageal and gastric fundus varicose veins, which relates to the technical field of pipe connecting components and comprises a first through pipe, a conversion cavity is arranged at one end of the first through pipe, a fourth through pipe is arranged at the other end of the conversion cavity, a second through pipe is arranged on one side of the conversion cavity, and a third through pipe is arranged on the other side of the second through pipe. A conversion plate is arranged in the conversion cavity and composed of a first gate plate, a second gate plate, a third gate plate and a fourth gate plate, the first gate plate and the fourth gate plate are oppositely arranged, the included angle between the second gate plate and the third gate plate is 90 degrees, and the included angle between the second gate plate and the fourth gate plate is 45 degrees. The included angle between the first gate plate and the second gate plate is 45 degrees. By arranging a series of structures, the lauromacrogol injection, the tissue glue injection and the 50% glucose injection can be respectively injected without pulling and inserting the liquid injection tube, so that the liquid medicine injection efficiency is improved, and the leakage risk is reduced.
Owner:西安国际医学中心有限公司
Biological scaffold and method for fabricating the same
A biological scaffold in the present invention comprises a main body, a biological material layer, and an optional tissue adhesive layer. The main body at least has a non-constituted collagen matrix. The biological material layer is coated at least on a surface of the main body, and the tissue adhesive layer is disposed at least on another surface of the main body. When the biological scaffold is adhered to a tissue through the tissue adhesive layer, a plurality of cells move from the tissue to either the adhesive layer or the biological material layer for tissue repairing or regeneration.
Owner:NAT CHENG KUNG UNIV