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11 results about "Tissue glue" patented technology
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Tissue Adhesive Glue. Tissue adhesive glue has been a revolutionary step in the management of lacerations. Tissue glue is indicated for low tension wounds, or occasionally higher tension wounds that have been properly undermined and layered.
Medical tissue adhesive, medical tissue dry adhesive patch and preparation method and application thereof
ActiveCN116617444BSurgical adhesivesPharmaceutical delivery mechanismAdhesion strengthAnti bacterial
The present application relates to the field of medical tissue adhesive, in particular to a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The present application provides a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The medical tissue adhesive provided by the present application comprises: 1wt%-30wt% of acidic polyglutamic acid; 1wt%-30wt% of spherical protein; and the balance of water. The medical tissue adhesive provided by the present application has high tissue adhesion strength and fast hemostatic sealing speed in a wet physiological environment, meets the requirements of rapid and efficient tissue hemostatic sealing, and can be applied to rapid hemostasis of tissue wounds in a wet physiological environment, sealing of wound liquid leakage, healing and repair of wound tissue, and antibacterial of wounds. Experiments show that the dry adhesive patch made of the adhesive provided by the present application has high tissue adhesion strength in a wet physiological environment, and the adhesion strength to a wet pigskin tissue can reach more than 60kPa.
Owner:CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES
A non-invasive cervical cancer orthotopic model modeling method of mice
The present application relates to in situ model modeling method, especially for a kind of non-invasive cervical cancer in situ model modeling method of mouse, including selecting several 8 weeks old BALB / c-nude mouse, all mice are divided into non-invasive group and operation group, the age, weight of two groups of mice are compared, and there is no statistically significant difference;Non-invasive group is widened with the cotton stick of diameter 3mm and wipes dry vagina, the tumor block with luciferase fluorescence is immersed in modified hydrogel, after heating and making modified hydrogel solidification, the tissue glue mixed with hard gypsum in modified hydrogel is dropped on the surface of modified hydrogel and quickly inserted into vagina, when there is obstruction, stop deepening, pause 30s and wait for tissue glue to be completely dry, when tumor block is fixed in cervix, it is modeling completion;Operation group first opens abdominal cavity, and tumor tissue of same size is sutured on cervix.This kind of non-invasive cervical cancer in situ model modeling method of mouse, using non-invasive method to replace operation method to establish non-invasive cervical cancer in situ model, can reduce the pain of mouse, reduce experimental difficulty.
Owner:SHANGHAI RES CENT FOR MODEL ORGANISMS
A biomimetic medical tissue adhesive and a preparation method thereof
The application relates to the technical field of medical materials, and particularly discloses a kind of bionic medical tissue adhesive and a preparation method thereof.A kind of bionic medical tissue adhesive is made of raw materials containing the following weight parts: alpha-cyano octyl acrylate 30-35 parts;degradable polymer material 20-30 parts;gelatin 1-5 parts;polyethylene glycol 2-5 parts;sterile water 20-30 parts;sodium alginate 2-4 parts;antibacterial agent 8-10 parts;stabilizing protective agent 1-3 parts;mussel extract 1-3 parts;slug extract 1-3 parts;its preparation method is: polyethylene glycol, sterile water, sodium alginate, antibacterial agent, stabilizing protective agent, mussel extract and slug extract are mixed, and stirred uniformly;then alpha-cyano octyl acrylate, degradable polymer material and gelatin are added, heated to 40-60 DEG C and stirred for 20-40 min, and the bionic medical tissue adhesive can be obtained.The bionic medical tissue adhesive of the application can better handle the skin tissue changes occurring in the proliferation period, so that the prominence of the scar formed in the later period is smaller, the whole is relatively flat and smooth, and thus the scar is greatly improved.
Owner:SHANGHAI JIAXIN BIOTECHNOLOGY CO LTD
Application of alpha-n-butyl cyanoacrylate tissue glue in treatment of diverticulum in digestive tract
The invention discloses application of alpha-cyanoacrylate n-butyl ester tissue glue in treatment of diverticulum of digestive tract. The tissue glue is used for preparing a medicine for treating the diverticulum of the digestive tract; during treatment, the diverticulum is injected through an endoscope, tissue glue makes contact with tissue fluid to be rapidly polymerized, the diverticulum is sealed, diverticulum complications are prevented, biocompatibility is good, degradation is achieved, no residues exist, the treatment effective rate is 100%, no complications exist, and the recurrence rate is low.
Owner:AFFILIATED HOSPITAL OF NANTONG UNIV
Improved formulation of medical tissue glue for treatment of esophageal varices and injection method
The application discloses a medical tissue glue modified formula and injection method for treating esophageal varices, and relates to the field of tissue glue; the medical tissue glue modified formula and injection method for treating esophageal varices introduce polyoxyl glycol as a modifier, not only reduce the brittleness and hardness of n-butyl alpha-cyanoacrylate after polymerization, make the formed vascular embolus more flexible, significantly reduce the cutting risk of traditional hard glue block to thin-walled mucosa, thereby reduce the incidence of postoperative glue leakage ulcer and rebleeding; at the same time, polyoxyl glycol itself as a hardener can synergistically damage the vascular endothelium, accelerate thrombosis and vascular fibrosis, and improve the long-term occlusion effect; secondly, the addition of dragon's blood extract or nano-silver and other antibacterial components in the formula can actively inhibit local bacterial colonization, effectively reduce the risk of postoperative sepsis for the clinical pain points of low immunity and easy infection of patients with cirrhosis.
Owner:徐婷
Compositions, devices and kits for selective internal radiation therapy of hepatocellular carcinoma
The present invention relates to a radionuclide dosage regimen for the treatment of gastrointestinal cancer (e.g., hepatocellular carcinoma (HCC)) by brachytherapy employing a two-component surgical sealant and / or adhesive (e.g., tissue glue) and radioisotope-loaded microspheres. The effective dosage range of administration is 0.4-220 MBq, and the specific dosage depends on the size of a target tumor.
Owner:BETAGLU THERAPEUTICS AG
Mesoscopic phase enhanced polyphenol-based aggregate adhesive and preparation method thereof
The invention discloses a mesoscopic phase enhanced polyphenol-based aggregate adhesive and a preparation method thereof, and relates to the technical field of medical tissue adhesives. The preparation method of the adhesive comprises the following steps: step 1, preparing a polyphenol compound into a solution A; 2, preparing an epoxy group high polymer material into a solution B; 3, diluting a silanization reagent with acidic deionized water to obtain a solution C; and 4, mixing the solution B and the solution C, adding the obtained mixture into the solution A, and carrying out oscillation centrifugation to obtain the mesoscopic phase enhanced polyphenol-based aggregate adhesive. According to the preparation method, an organic-inorganic hybrid composite phase body with a mesoscopic phase structure is assembled around an epoxy polymer material phase after being hydrolyzed by a silanization reagent, so that the hydrogen bond and hydrophobic interaction between the epoxy polymer material phase and a polyphenol compound are enhanced. The prepared adhesive has high adhesion on the tissue surface while having the aim of being degradable, and can be used as a good medical tissue adhesive.
Owner:SOUTH CHINA UNIV OF TECH
Medical tissue glue for pancreas plugging as well as preparation method and application of medical tissue glue
The invention relates to medical tissue glue for pancreas plugging as well as a preparation method and application of the medical tissue glue. The medical tissue glue composition for forming the medical tissue glue disclosed by the invention comprises a medical tissue glue component and a chelating agent component, wherein the medical tissue glue component comprises a first component and a second component, and the first component comprises four-arm polyethylene glycol amine; the second component is prepared from four arm-polyethylene glycol-succinimide glutaric acid ester; wherein m and n are natural numbers; the chelating agent component comprises polyphenol. The medical tissue glue prepared from the medical tissue glue composition disclosed by the invention can be firmly adhered to the surface of pancreatic tissue and can bear dynamic pressure of pancreatic juice leakage and enzymatic degradation activity of pancreatic juice, and more importantly, the medical tissue glue disclosed by the invention has excellent antibacterial ability and can prevent infection caused by long-term accumulation of pancreatic juice leakage.
Owner:BEIJING BIOSIS HEALING BIOLOGICAL TECH CO LTD
Mechanical grabbing structure with adjusting structure for wet tissue glue spraying
Owner:GUANGZHOU BAIHUA DAILY NECESSITIES CO LTD
High-performance degradable biomedical tissue adhesive and preparation method and application thereof
Owner:SICHUAN UNIV +1
K-type cross-shaped two-way connector for sclerotherapy of esophageal and gastric fundus varicose veins
The utility model discloses a K type cross two-way interface for hardening treatment of esophageal and gastric fundus varicose veins, which relates to the technical field of pipe connecting components and comprises a first through pipe, a conversion cavity is arranged at one end of the first through pipe, a fourth through pipe is arranged at the other end of the conversion cavity, a second through pipe is arranged on one side of the conversion cavity, and a third through pipe is arranged on the other side of the second through pipe. A conversion plate is arranged in the conversion cavity and composed of a first gate plate, a second gate plate, a third gate plate and a fourth gate plate, the first gate plate and the fourth gate plate are oppositely arranged, the included angle between the second gate plate and the third gate plate is 90 degrees, and the included angle between the second gate plate and the fourth gate plate is 45 degrees. The included angle between the first gate plate and the second gate plate is 45 degrees. By arranging a series of structures, the lauromacrogol injection, the tissue glue injection and the 50% glucose injection can be respectively injected without pulling and inserting the liquid injection tube, so that the liquid medicine injection efficiency is improved, and the leakage risk is reduced.
Owner:西安国际医学中心有限公司