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Adhesive and preparation method thereof

An adhesive and pre-glue technology, applied in surgical adhesives, applications, medical science, etc., can solve problems such as insufficient bonding strength and poor mechanical properties

Inactive Publication Date: 2020-10-23
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, clinical adhesives still have disadvantages such as poor mechanical properties and insufficient bonding strength. Therefore, it is urgent to develop tissue adhesives with high mechanical strength, high bonding strength, and good biological safety.

Method used

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  • Adhesive and preparation method thereof
  • Adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] An adhesive and a preparation method thereof: 5.0 g of bovine serum albumin (BSA) was weighed and dissolved in 10 mL of aqueous solution to form a 50% (wt / vol) BSA aqueous solution, and the mixed solution was stirred at room temperature for about 30 minutes to form a uniform solution. Slowly add 300 μL of 10% (wt / vol) glutaraldehyde solution under stirring at room temperature, and stir at room temperature for 2 minutes to form a pregel. Stir well under the condition of UV (30mW / cm 2 ) in an ultraviolet box, 365nm ultraviolet light is irradiated for 3 minutes to form an adhesive.

Embodiment 2

[0031] An adhesive and a preparation method thereof: 7.0 g of bovine serum albumin (BSA) was weighed and dissolved in 10 mL of aqueous solution to form a 70% (wt / vol) BSA aqueous solution, and the mixed solution was stirred at room temperature for about 40 minutes to form a uniform solution. Slowly add 300 μL of 10% (wt / vol) glutaraldehyde solution under stirring at room temperature, and stir at room temperature for 2 minutes to form a pregel. Stir well under the condition of UV (30mW / cm 2 ) in an ultraviolet box, 380nm ultraviolet light is irradiated for 3 minutes to form an adhesive.

Embodiment 3

[0033] An adhesive and a preparation method thereof: 5.0 g of bovine serum albumin (BSA) was weighed and dissolved in 10 mL of aqueous solution to form a 50% (wt / vol) BSA aqueous solution, and the mixed solution was stirred at room temperature for about 30 minutes to form a uniform solution. Slowly add 300 μL of 10% (wt / vol) glutaraldehyde solution under stirring at room temperature, and stir at room temperature for 2 minutes to form a pre-gel, add 0.6% (wt / vol), that is, 60 mg of dihydropropidine solid powder into the pre-gel, and Stir well under the condition of UV (30mW / cm 2 ) in an ultraviolet box, 365nm ultraviolet light is irradiated for 3 minutes to form an adhesive.

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Abstract

The invention provides an adhesive and a preparation method thereof. The adhesive comprises bovine serum albumin, a cross-linking agent and diazirine. In the adhesive disclosed by the invention, the diazirine can quickly generate carbene under the irradiation of ultraviolet light, the carbene and groups such as-COOH and-NH2 which are close to the carbine are subjected to an insertion reaction to generate covalent bonds, and the interaction force between bovine serum protein molecules and between protein and tissues is enhanced, so that the mechanical strength and the bonding strength of the tissue adhesive are enhanced.

Description

technical field [0001] The invention belongs to the technical field of adhesives, in particular to an adhesive and a preparation method thereof. Background technique [0002] With the advancement of medical technology, the clinical demand for soft tissue adhesives is increasing. According to statistics, more than 4 million surgical operations are performed every year in the world. Surgical sutures or fibers are traditionally used to suture surgical wounds, but a series of problems such as complications caused by air or body fluid leakage have caused serious harm. It may even endanger the life of the patient. As early as the 1950s, people used tissue adhesives to solve the serious problems caused by surgical sutures. [0003] Tissue adhesive is an adhesive that connects two or more materials together through interface adhesion and material cohesion, and is used for tissue bonding instead of surgical sutures. [0004] At present, clinical adhesives still have disadvantages ...

Claims

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Application Information

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IPC IPC(8): A61L24/10
CPCA61L24/108
Inventor 国翠平刘群峰于珊纪禹行耿志杰鲁道欢裴大婷
Owner GUANGDONG PROV MEDICAL INSTR INST
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