89 results about "Tissue adhesives" patented technology

The invention discloses a catechol side group-containing polylysine derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) dissolving catechol acid in an organic phase, firstly adding NHS, stirring and dissolving until the materials are uniformly mixed, then adding EDC.HCl, and stirring and reacting to obtain a catechol-NHS intermediate solution; (2) dissolving polylysine or a salt thereof in a water phase, and adjusting the pH value to 6.0-7.0 by using an alkaline solution to obtain a solution of polylysine or a salt thereof; and (3) adding the intermediate solution obtained in the step (1) into the polylysine or the salt solution thereof obtained in the step (2), and maintaining the pH value of the reaction system at 5.0-6.0 by using an alkaline solution to obtain the catechol side group-containing polylysine derivative. The preparation method is short in reaction time and mild in reaction condition, and the obtained product is high in grafting rate and high in raw material conversion rate and has a good application prospect in the aspects of tissue adhesives and the like.

The invention discloses a medical pressure-sensitive adhesive patch based on citric acid, a preparation method and application, the medical pressure-sensitive adhesive patch is composed of an adhesion layer and an anti-adhesion layer, and the thickness ratio of the adhesion layer to the anti-adhesion layer is 1: 1-100: 1; the adhesion layer is obtained by polymerizing a citric acid unit and a polyhydroxy compound unit; the hydrophobic high-molecular polymer is selected from at least one of a polylactic acid-glycolic acid copolymer, polylactic acid, polyurethane and polyether urethane. According to the preparation method, three carboxyl groups in the citric acid not only can be used for esterification reaction with polyhydric alcohols to form a network, but also can provide excellent adhesive force for contact between the adhesive patch and the tissue surface through electrostatic interaction or hydrogen-bond interaction. The anti-sticking layer prepared from the hydrophobic high-molecular polymer can effectively resist invasion of external moisture and bacteria, so that the service time of the adhesive patch is prolonged; meanwhile, the anti-sticking layer can also play a supporting role, so that the mechanical strength of the adhesive tape is improved.

The present application relates to the field of medical tissue adhesive, in particular to a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The present application provides a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The medical tissue adhesive provided by the present application comprises: 1wt%-30wt% of acidic polyglutamic acid; 1wt%-30wt% of spherical protein; and the balance of water. The medical tissue adhesive provided by the present application has high tissue adhesion strength and fast hemostatic sealing speed in a wet physiological environment, meets the requirements of rapid and efficient tissue hemostatic sealing, and can be applied to rapid hemostasis of tissue wounds in a wet physiological environment, sealing of wound liquid leakage, healing and repair of wound tissue, and antibacterial of wounds. Experiments show that the dry adhesive patch made of the adhesive provided by the present application has high tissue adhesion strength in a wet physiological environment, and the adhesion strength to a wet pigskin tissue can reach more than 60kPa.

The present invention relates to a tissue adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue reactive polymer, and a tissue adhesive device for sealing the dura mater comprising the tissue adhesive polymer blend.

The present invention discloses an instant-adhesive strong-tough wet tissue tape and a preparation method thereof. The preparation of the instant-adhesive strong-tough wet tissue tape comprises the following steps: S1, reacting 3,4-dihydroxyphenylacetic acid with glycidyl methacrylate to synthesize 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate; S2, dissolving chitosan in an acrylic acid aqueous solution, then adding 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate and a photoinitiator to obtain a mixed solution; S3, applying the mixed solution to the surface of a polymer film treated with a plasma cleaner, and then curing under ultraviolet light to obtain the instant-adhesive strong-tough wet tissue tape. This invention designs and synthesizes novel catechol compounds with long alkyl side chains and uses them to manufacture an instantly adhesive, strong, and resilient wet tissue tape. This tape is thin, flexible, and optically transparent, conforming to various substrates and allowing visual inspection of the substrate's state. Prior to use, the tape is dry and non-sticky, but upon contact with water or blood, it rapidly bonds to wet biological tissue. The tape exhibits exceptionally strong interfacial toughness and adhesion strength to wet biological tissue, far exceeding existing commercial adhesives and some other wet tissue adhesives. Therefore, the instantly adhesive, strong, and resilient wet tissue tape can be used for wound closure and hemostasis.

The present disclosure generally relates to hydrogels, e.g., hydrogels formed by crosslinking. Such hydrogels can provide robust gelation and adhesion, while retaining bioactivity. The hydrogel of the disclosure can be implemented in many applications, for non-limiting example, antifouling and lubricious coatings, tissue adhesives, and wound dressings. The hydrogel offers desirable biocompatibility, bioactivity, biodegradability, and mechanical properties.

The present disclosure relates generally to compositions, systems, and methods for vascular closure, such as upon applying an implantable article to biological tissue and thereby adhering said article to the tissue to which it has been applied. More specifically, the disclosure relates to compositions, systems, and methods that involve articles modified with crosslinkable compositions, the compositions facilitating crosslinking between the article and biological tissue at physiological pH and temperature.

The application discloses a kind of preparation and application of microbial basic protein and adhesive proteoglycan hydrogel, belong to the field of biomaterials.Basic protein is extracted from microbial cells in the present application, using supramolecular assembly method, basic protein and acidic polysaccharide electrostatic assembly protein glycan gel material with strong tissue adhesion, the method is simple, widely available, and the cost is almost negligible.The tissue adhesive provided by the present application has immediate tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, which is beneficial to cope with different types of bleeding scene and irregular wound healing.Through cell compatibility and blood compatibility test, the results show that the material has excellent biocompatibility, and the basic protein has super strong bacteriostatic ability, avoids the invasion of foreign bacteria in the wound repair process, and has strong healing ability, greatly shortens the healing period of wound.

The application relates to the technical field of medical materials, and particularly discloses a kind of bionic medical tissue adhesive and a preparation method thereof.A kind of bionic medical tissue adhesive is made of raw materials containing the following weight parts: alpha-cyano octyl acrylate 30-35 parts;degradable polymer material 20-30 parts;gelatin 1-5 parts;polyethylene glycol 2-5 parts;sterile water 20-30 parts;sodium alginate 2-4 parts;antibacterial agent 8-10 parts;stabilizing protective agent 1-3 parts;mussel extract 1-3 parts;slug extract 1-3 parts;its preparation method is: polyethylene glycol, sterile water, sodium alginate, antibacterial agent, stabilizing protective agent, mussel extract and slug extract are mixed, and stirred uniformly;then alpha-cyano octyl acrylate, degradable polymer material and gelatin are added, heated to 40-60 DEG C and stirred for 20-40 min, and the bionic medical tissue adhesive can be obtained.The bionic medical tissue adhesive of the application can better handle the skin tissue changes occurring in the proliferation period, so that the prominence of the scar formed in the later period is smaller, the whole is relatively flat and smooth, and thus the scar is greatly improved.

The present application relates to a kind of mussel-based composite coacervate based on mussel adhesive protein and its preparation method and purposes, the mussel-based composite coacervate includes mussel adhesive protein and anionic polyelectrolyte material;The mass ratio of mussel adhesive protein and anionic polyelectrolyte material is (0.05~4):1;The oxidation rate of dopa residue in the mussel adhesive protein in the composite coacervate is 0.1%~70.0%.The present application realizes the accurate control of the preparation of the composite coacervate formed by regulating the concentration, mass ratio and system pH of mussel adhesive protein and anionic polyelectrolyte material, and then improves its performance and effect as tissue adhesive, wound repair dressing, acute hemostatic material, local drug delivery carrier and drug release system field or bone tissue repair, cartilage repair and tissue filling and support field.

Provided is a porous sheet having high biocompatibility and adhesive strength, and further having pliability and / or flexibility.　The porous sheet includes: a second gelatin having a hydrocarbon group introduced into a first gelatin; and an unreacted crosslinking agent dispersed in the second gelatin. The second gelatin includes a structure represented by formula (1).

The present invention relates to a method for manufacturing a crosslinked copolymer from at least one CO2-loaded polyamine and at least one polyelectrophilic monomer. The present invention also relates to a porous material consisting of the crosslinked copolymer that can be or is obtained by the claimed method, and to the use thereof in various applications, and in particular as a tissue adhesive foam.

The invention provides a tissue adhesive material as well as a preparation method and application thereof. The tissue bonding material is prepared from the following raw materials: a polymer monomer, wherein the polymer monomer comprises an acrylic monomer and an acrylamide monomer; the modified chitosan compound is obtained by modifying a chitosan compound through a polyphenol compound, and the polyphenol compound has two or more phenolic hydroxyl groups; and an initiator, wherein the initiator comprises a photoinitiator and a radical initiator. When the tissue bonding material is in contact with a wet or wet tissue surface, interface liquid existing between the bonding material and the wet tissue surface can be quickly absorbed and removed, and carboxyl, amido and catechol groups of the tissue bonding material can form a large number of molecular bonds with molecules on the wet tissue surface, so that instant bonding on the wet tissue surface is formed; and high adhesiveness can be maintained for a long time.

The present application relates to the technical field of biological adhesives, and particularly relates to a human tissue adhesive and a preparation method thereof, which comprises the following raw materials: modified polydopamine nanoparticles, sulfonated carbon nanotubes, selenium-calcium phosphate composite nanoparticles (Se-HAp NPs), growth factors, curcumin, quercetin, poly (N-isopropyl acrylamide) and polylactic acid. In the present application, the modified polydopamine nanoparticles significantly improve the wet-state adhesive strength of the adhesive, and the flexible nano-supporting effect of the sulfonated carbon nanotubes synergistically enhances the adhesion and flexibility thereof, and the two form a stable nano-network structure to support the uniform distribution of the Se-HAp NPs, the sulfonated carbon nanotubes ensure the functional integrity of the Se-HAp NPs in a dynamic environment, and the Se-HAp NPs together with the modified polydopamine nanoparticles improve the biological activity and stability of the adhesive, and promote tissue repair, so that the adhesive can adapt to a dynamic tissue environment.

The application discloses a tissue adhesive and a preparation method and application thereof, and belongs to the field of medical materials.The tissue adhesive comprises a copolymer composed of at least one of acrylic acid and methacrylic acid and a hydrochloride salt, the hydrochloride salt is at least one of 2-aminoethyl methacrylic acid ester hydrochloride and 2-aminoethyl acrylic acid ester hydrochloride, and the tissue adhesive can further comprise a crosslinked polymer formed by crosslinking at least one of polyacrylic acid and polymethacrylic acid with a polymer, and the polymer is formed by polymerization of the hydrochloride salt and a zwitterionic betaine.The copolymer can quickly absorb moisture on a wet tissue surface to form a gel and adhere to the tissue surface, so that a soft tissue wound, especially a low-pH microenvironment soft tissue wound, is closed; and the crosslinked polymer can be firmly combined on the surface of the copolymer and quickly form an anti-adhesion gel, which effectively prevents the surrounding tissue from being adhered after an operation as a physical barrier.

This invention relates to a composite tissue adhesive and its application in hemostasis, sterilization, and wound healing promotion. The adhesive comprises component A and component B. Component A includes: methacrylic anhydride-modified gelatin, dodecaldehyde-modified chitosan, polycaprolactone / methacrylic anhydride-modified gelatin blended nanofibers, a photosensitive crosslinking agent, and water. Component B is an aqueous solution of an amino crosslinking agent. In use, components A and B are mixed, injected into the wound, and irradiated with ultraviolet or blue light. The tissue adhesive of this invention is injected directly into the wound site in liquid form. Upon light irradiation, it forms a gel structure in situ with a strength comparable to that of skin, simultaneously providing hemostasis, sterilization, and wound healing promotion.

The present application relates to the technical field of adhesives, and in particular to a medical tissue adhesive and a preparation method thereof. The medical tissue adhesive comprises the following raw materials in parts by weight: 8-12 parts of a polyglutamic acid grafted thermosensitive polymer, 0.8-1.2 parts of vitamin C, 0.8-1.2 parts of sodium periodate, 0-1.2 parts of sodium alginate, 0-1.2 parts of chitosan oligosaccharide, and 2.5-3.5 parts of polyethylene glycol; the polyglutamic acid grafted thermosensitive polymer is prepared by reacting polyglutamic acid and a thermosensitive polymer containing an acid anhydride, and the temperature-sensitive polymer is prepared by copolymerizing an acid anhydride containing a double bond, N-vinyl pyrrolidone, and N-isopropylacrylamide; the medical tissue adhesive has the advantages of improving the hemostatic effect and adhesion of the medical adhesive.

The invention discloses application of alpha-cyanoacrylate n-butyl ester tissue glue in treatment of diverticulum of digestive tract. The tissue glue is used for preparing a medicine for treating the diverticulum of the digestive tract; during treatment, the diverticulum is injected through an endoscope, tissue glue makes contact with tissue fluid to be rapidly polymerized, the diverticulum is sealed, diverticulum complications are prevented, biocompatibility is good, degradation is achieved, no residues exist, the treatment effective rate is 100%, no complications exist, and the recurrence rate is low.

The present disclosure generally relates to hydrogels, e.g., hydrogels formed by crosslinking. Such hydrogels can provide robust gelation and adhesion, while retaining bioactivity. The hydrogel of the disclosure can be implemented in many applications, for non-limiting example, antifouling and lubricious coatings, tissue adhesives, and wound dressings. The hydrogel offers desirable biocompatibility, bioactivity, biodegradability, and mechanical properties.

A process for sterilization of tissue adhesive is provided that includes heating a container containing a quantity of tissue adhesive to maximal temperature of between 180°C and 230°C for a Time Averaged Sterilization Temperature heat flow up to 500,000 C*min / mmol relative to the millimolar quantity of tissue adhesive. The container is cooled to sterilize the cyanoacrylate-based tissue adhesive. A composition of matter results that includes a container with a hermetic seal. A quantity of sterilized tissue adhesive is provided within the container and has storage stability at standard temperature and pressure of at least 36 months.

A method for individual tagging of giant freshwater prawns includes the following steps: S1, Pre-tag preparation: Purchasing implantable glass tube-encapsulated RFID chip tags, matching syringes or injection equipment, animal tissue adhesive, and thin plastic film discs; Temporarily raising the prawns to be tagged to a length of more than 3cm, from the base of the eyestalk to the end of the telson; S2, Preparing the prawns to be tagged: Removing the prawns to be tagged from the temporary holding tank and placing them in water at 16-22℃ to await tagging; In summary, the tagging method of the present invention greatly increases the overall tag retention rate and survival tag retention rate without changing the mortality rate, making it possible to tag giant freshwater prawns with implantable tags, and allowing the tags to accompany the prawns for a long period of time, making it possible to apply implantable tags to long-term production experiments such as breeding.

The invention discloses a stem cell microcapsule-entrapped tissue adhesive, a preparation method and application, the tissue adhesive is composed of stem cell microcapsule-entrapped hydrogel and a biological adhesive, and live stem cells are entrapped in the tissue adhesive; the stem cells are selected from at least one of umbilical cord mesenchymal stem cells, bone marrow mesenchymal stem cells, adipose-derived stem cells, embryonic stem cells and induced pluripotent stem cells; the biological adhesive is formed by compounding a hydrophilic polymer and a block polymer, wherein the mass ratio of the hydrophilic polymer to the block polymer is (1: 5)-(5: 1); the transmittance of the tissue adhesive is 60-100%, the tissue adhesive strength is 20-200 kPa, and the volume swelling ratio is smaller than or equal to 50%. According to the scheme, the stem cell entrapped microcapsule and the biological adhesive are mixed to prepare the tissue adhesive, and the adhesive can be used as bio-ink to be assembled into a bionic scaffold through 3D printing or directly injected to an injured part, so that the tissue adhesive has a wide application prospect.

The application discloses an adhesion-treatment synergic integrated tissue adhesive and a preparation method and application thereof, and belongs to the technical field of medical adhesives. The adhesion-treatment synergic integrated tissue adhesive comprises: (1) 100 parts by mass of an adhesion precursor, wherein the adhesion precursor is a mixture of a silk fibroin-polyphenol composite hydrogel and urea; and (2) 0.1-100 parts by mass of a medically acceptable metal oxide particle, wherein the metal oxide particle has a hollow mesoporous shell structure and is loaded with a tissue repair promoting component. The adhesion-treatment synergic integrated tissue adhesive not only has excellent adhesion strength, mechanical bearing capacity and a suitable curing window time, can be adapted to the repair of complex tissue damage sites, but also has biological activity and good compatibility for promoting tissue healing, so that the adhesion fixation, the repair and regeneration of the tissue are effectively realized.

The present invention relates to the manufacture of a photo-crosslinkable biodegradable tissue adhesive using a multinetwork-forming copolymer, and provides a hyaluronic acid copolymer compound having excellent elongation, mechanical properties, and tissue adhesion. The compound fundamentally does not undergo phase separation, and enables the manufacture of a tissue adhesive with desired adhesive characteristics and physical characteristics.

An adhesive composition described herein comprises an aqueous solvent; and a population of first nanoparticles dispersed in the aqueous solvent, the first nanoparticles comprising a negative or positive charge, and an average size in three dimensions of 1 nm to 1000 nm. In some embodiments, a population of second nanoparticles is dispersed in the aqueous solvent, the second nanoparticles comprises a negative or positive charge opposite the charge of the population of first nanoparticles. In some embodiments, the population of first nanoparticles comprise an average first size in three dimensions, and the population of second nanoparticles comprise an average second size in three dimensions that is different from the average first size of the first nanoparticles.

A wound healing composition is provided that includes a tissue adhesive or epithelial tissue healing agent and metal-modified cerium oxide nanoparticles (mCNPs). The nCNPs have a predominant 3+ surface charge and are in a range of about 3-35 nanometers (nm) in size and mixed in an amount that is in a range of about 0.01 to 0.1 weight percentage of a mixture having the tissue adhesive or epithelial tissue healing agent and the mCNPs. The metal (m) is a stable metallic metal with antimicrobial properties and non-ionizing. The mCNPs includes AgCNP2. A method is provided that uses the healing composition to treat a wound or epithelial tissue. The composition can be used to treat the skin or eye and / or subcutaneous tissue.

A medical adhesive composition particularly suited for use as a wound or surgical incision closure, sealant, adhesive or the like for living tissue. Advantageously, the adhesive composition is applied as a liquid and quickly polymerizes into a durable film, coating, or layer which exhibits desirable properties including, but not limited to, strength, flexibility, moisture vapor transmission and oxygen permeability. Kits including the adhesive composition, an applicator and optionally an adherable substrate such as a mesh are described along with methods for preparing the kits. The adhesive compositions are able to readily hold skin edges of wounds or surgical incisions closed in order to provide a layer of protection against harmful organisms that can cause infection.

The present disclosure relates to a medical tissue adhesive for pancreatic plugging and the preparation method and use thereof. The medical tissue adhesive composition forming the medical tissue adhesive of the present disclosure comprises a medical tissue adhesive component and a chelating agent component; wherein the medical tissue adhesive component comprises a first component and a second component, the first component comprises four-arm polyethylene glycol amine, and the second component comprises four-arm-polyethylene glycol-succinimidyl glutarate; wherein m and n are natural numbers; and the chelating agent component comprises polyphenol. The medical tissue adhesive prepared from the medical tissue adhesive composition of the present disclosure is capable of firmly binding to the surface of the pancreatic tissue, and is capable of withstanding the dynamic pressure as a result of pancreatic juice leakage and the enzymatic degradation activity of pancreatic juice. More importantly, the medical tissue adhesive of the present disclosure has an excellent antibacterial ability and is capable of preventing the infection caused by the long-term accumulation of the leaked pancreatic juice.

This invention provides a multifunctional injectable tissue adhesive, characterized by comprising component A: an active protein with chemically modified reduced polyphenol groups and a surface rich in RGD sequences, lysine, aspartic acid, and / or glutamic acid; component B: a natural polysaccharide with chemically modified active ester groups; and gelation buffers: an alkaline buffer solution and an acidic solution. The tissue adhesive provided by this invention combines good biocompatibility and adhesion, exhibits antibacterial activity, and can promote tissue healing, showing great promise for clinical application.

The invention discloses preparation and application of a proteoglycan colloid material capable of rapidly stopping bleeding and promoting wound healing, and belongs to the field of biological materials. Basic amino acid rich in lysine or arginine is designed and expressed through molecular engineering, and then basic protein and hyaluronic acid with negative electricity are combined through a supramolecular assembly method to prepare a proteoglycan material with antibacterial ability. Then, recombinant mucoprotein rich in tyrosine is designed and expressed, and a DOPA adhesion group is formed through tyrosinase modification, so that the instant adhesion of the tissue adhesion material is enhanced. The amino acid of the basic protein remarkably enhances the interaction of various molecules of proteoglycan, meanwhile, the basic amino acid endows the tissue adhesive with excellent antibacterial ability, and the tissue adhesive provided by the invention has instant tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, and is suitable for being used in the field of medical instruments. The healing of different types of bleeding scenes and irregular wounds is facilitated.