54 results about "Tissue adhesives" patented technology

The invention discloses a catechol side group-containing polylysine derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) dissolving catechol acid in an organic phase, firstly adding NHS, stirring and dissolving until the materials are uniformly mixed, then adding EDC.HCl, and stirring and reacting to obtain a catechol-NHS intermediate solution; (2) dissolving polylysine or a salt thereof in a water phase, and adjusting the pH value to 6.0-7.0 by using an alkaline solution to obtain a solution of polylysine or a salt thereof; and (3) adding the intermediate solution obtained in the step (1) into the polylysine or the salt solution thereof obtained in the step (2), and maintaining the pH value of the reaction system at 5.0-6.0 by using an alkaline solution to obtain the catechol side group-containing polylysine derivative. The preparation method is short in reaction time and mild in reaction condition, and the obtained product is high in grafting rate and high in raw material conversion rate and has a good application prospect in the aspects of tissue adhesives and the like.

The invention discloses a medical pressure-sensitive adhesive patch based on citric acid, a preparation method and application, the medical pressure-sensitive adhesive patch is composed of an adhesion layer and an anti-adhesion layer, and the thickness ratio of the adhesion layer to the anti-adhesion layer is 1: 1-100: 1; the adhesion layer is obtained by polymerizing a citric acid unit and a polyhydroxy compound unit; the hydrophobic high-molecular polymer is selected from at least one of a polylactic acid-glycolic acid copolymer, polylactic acid, polyurethane and polyether urethane. According to the preparation method, three carboxyl groups in the citric acid not only can be used for esterification reaction with polyhydric alcohols to form a network, but also can provide excellent adhesive force for contact between the adhesive patch and the tissue surface through electrostatic interaction or hydrogen-bond interaction. The anti-sticking layer prepared from the hydrophobic high-molecular polymer can effectively resist invasion of external moisture and bacteria, so that the service time of the adhesive patch is prolonged; meanwhile, the anti-sticking layer can also play a supporting role, so that the mechanical strength of the adhesive tape is improved.

The present application relates to the field of medical tissue adhesive, in particular to a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The present application provides a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The medical tissue adhesive provided by the present application comprises: 1wt%-30wt% of acidic polyglutamic acid; 1wt%-30wt% of spherical protein; and the balance of water. The medical tissue adhesive provided by the present application has high tissue adhesion strength and fast hemostatic sealing speed in a wet physiological environment, meets the requirements of rapid and efficient tissue hemostatic sealing, and can be applied to rapid hemostasis of tissue wounds in a wet physiological environment, sealing of wound liquid leakage, healing and repair of wound tissue, and antibacterial of wounds. Experiments show that the dry adhesive patch made of the adhesive provided by the present application has high tissue adhesion strength in a wet physiological environment, and the adhesion strength to a wet pigskin tissue can reach more than 60kPa.

The present invention relates to a tissue adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue reactive polymer, and a tissue adhesive device for sealing the dura mater comprising the tissue adhesive polymer blend.

The present disclosure relates generally to compositions, systems, and methods for vascular closure, such as upon applying an implantable article to biological tissue and thereby adhering said article to the tissue to which it has been applied. More specifically, the disclosure relates to compositions, systems, and methods that involve articles modified with crosslinkable compositions, the compositions facilitating crosslinking between the article and biological tissue at physiological pH and temperature.

The application discloses a kind of preparation and application of microbial basic protein and adhesive proteoglycan hydrogel, belong to the field of biomaterials.Basic protein is extracted from microbial cells in the present application, using supramolecular assembly method, basic protein and acidic polysaccharide electrostatic assembly protein glycan gel material with strong tissue adhesion, the method is simple, widely available, and the cost is almost negligible.The tissue adhesive provided by the present application has immediate tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, which is beneficial to cope with different types of bleeding scene and irregular wound healing.Through cell compatibility and blood compatibility test, the results show that the material has excellent biocompatibility, and the basic protein has super strong bacteriostatic ability, avoids the invasion of foreign bacteria in the wound repair process, and has strong healing ability, greatly shortens the healing period of wound.

The application relates to the technical field of medical materials, and particularly discloses a kind of bionic medical tissue adhesive and a preparation method thereof.A kind of bionic medical tissue adhesive is made of raw materials containing the following weight parts: alpha-cyano octyl acrylate 30-35 parts;degradable polymer material 20-30 parts;gelatin 1-5 parts;polyethylene glycol 2-5 parts;sterile water 20-30 parts;sodium alginate 2-4 parts;antibacterial agent 8-10 parts;stabilizing protective agent 1-3 parts;mussel extract 1-3 parts;slug extract 1-3 parts;its preparation method is: polyethylene glycol, sterile water, sodium alginate, antibacterial agent, stabilizing protective agent, mussel extract and slug extract are mixed, and stirred uniformly;then alpha-cyano octyl acrylate, degradable polymer material and gelatin are added, heated to 40-60 DEG C and stirred for 20-40 min, and the bionic medical tissue adhesive can be obtained.The bionic medical tissue adhesive of the application can better handle the skin tissue changes occurring in the proliferation period, so that the prominence of the scar formed in the later period is smaller, the whole is relatively flat and smooth, and thus the scar is greatly improved.

The present application relates to a kind of mussel-based composite coacervate based on mussel adhesive protein and its preparation method and purposes, the mussel-based composite coacervate includes mussel adhesive protein and anionic polyelectrolyte material;The mass ratio of mussel adhesive protein and anionic polyelectrolyte material is (0.05~4):1;The oxidation rate of dopa residue in the mussel adhesive protein in the composite coacervate is 0.1%~70.0%.The present application realizes the accurate control of the preparation of the composite coacervate formed by regulating the concentration, mass ratio and system pH of mussel adhesive protein and anionic polyelectrolyte material, and then improves its performance and effect as tissue adhesive, wound repair dressing, acute hemostatic material, local drug delivery carrier and drug release system field or bone tissue repair, cartilage repair and tissue filling and support field.

Provided is a porous sheet having high biocompatibility and adhesive strength, and further having pliability and / or flexibility.　The porous sheet includes: a second gelatin having a hydrocarbon group introduced into a first gelatin; and an unreacted crosslinking agent dispersed in the second gelatin. The second gelatin includes a structure represented by formula (1).

The invention provides a tissue adhesive material as well as a preparation method and application thereof. The tissue bonding material is prepared from the following raw materials: a polymer monomer, wherein the polymer monomer comprises an acrylic monomer and an acrylamide monomer; the modified chitosan compound is obtained by modifying a chitosan compound through a polyphenol compound, and the polyphenol compound has two or more phenolic hydroxyl groups; and an initiator, wherein the initiator comprises a photoinitiator and a radical initiator. When the tissue bonding material is in contact with a wet or wet tissue surface, interface liquid existing between the bonding material and the wet tissue surface can be quickly absorbed and removed, and carboxyl, amido and catechol groups of the tissue bonding material can form a large number of molecular bonds with molecules on the wet tissue surface, so that instant bonding on the wet tissue surface is formed; and high adhesiveness can be maintained for a long time.

This invention relates to a composite tissue adhesive and its application in hemostasis, sterilization, and wound healing promotion. The adhesive comprises component A and component B. Component A includes: methacrylic anhydride-modified gelatin, dodecaldehyde-modified chitosan, polycaprolactone / methacrylic anhydride-modified gelatin blended nanofibers, a photosensitive crosslinking agent, and water. Component B is an aqueous solution of an amino crosslinking agent. In use, components A and B are mixed, injected into the wound, and irradiated with ultraviolet or blue light. The tissue adhesive of this invention is injected directly into the wound site in liquid form. Upon light irradiation, it forms a gel structure in situ with a strength comparable to that of skin, simultaneously providing hemostasis, sterilization, and wound healing promotion.

The invention discloses application of alpha-cyanoacrylate n-butyl ester tissue glue in treatment of diverticulum of digestive tract. The tissue glue is used for preparing a medicine for treating the diverticulum of the digestive tract; during treatment, the diverticulum is injected through an endoscope, tissue glue makes contact with tissue fluid to be rapidly polymerized, the diverticulum is sealed, diverticulum complications are prevented, biocompatibility is good, degradation is achieved, no residues exist, the treatment effective rate is 100%, no complications exist, and the recurrence rate is low.

A process for sterilization of tissue adhesive is provided that includes heating a container containing a quantity of tissue adhesive to maximal temperature of between 180°C and 230°C for a Time Averaged Sterilization Temperature heat flow up to 500,000 C*min / mmol relative to the millimolar quantity of tissue adhesive. The container is cooled to sterilize the cyanoacrylate-based tissue adhesive. A composition of matter results that includes a container with a hermetic seal. A quantity of sterilized tissue adhesive is provided within the container and has storage stability at standard temperature and pressure of at least 36 months.

The invention discloses a stem cell microcapsule-entrapped tissue adhesive, a preparation method and application, the tissue adhesive is composed of stem cell microcapsule-entrapped hydrogel and a biological adhesive, and live stem cells are entrapped in the tissue adhesive; the stem cells are selected from at least one of umbilical cord mesenchymal stem cells, bone marrow mesenchymal stem cells, adipose-derived stem cells, embryonic stem cells and induced pluripotent stem cells; the biological adhesive is formed by compounding a hydrophilic polymer and a block polymer, wherein the mass ratio of the hydrophilic polymer to the block polymer is (1: 5)-(5: 1); the transmittance of the tissue adhesive is 60-100%, the tissue adhesive strength is 20-200 kPa, and the volume swelling ratio is smaller than or equal to 50%. According to the scheme, the stem cell entrapped microcapsule and the biological adhesive are mixed to prepare the tissue adhesive, and the adhesive can be used as bio-ink to be assembled into a bionic scaffold through 3D printing or directly injected to an injured part, so that the tissue adhesive has a wide application prospect.

The application discloses an adhesion-treatment synergic integrated tissue adhesive and a preparation method and application thereof, and belongs to the technical field of medical adhesives. The adhesion-treatment synergic integrated tissue adhesive comprises: (1) 100 parts by mass of an adhesion precursor, wherein the adhesion precursor is a mixture of a silk fibroin-polyphenol composite hydrogel and urea; and (2) 0.1-100 parts by mass of a medically acceptable metal oxide particle, wherein the metal oxide particle has a hollow mesoporous shell structure and is loaded with a tissue repair promoting component. The adhesion-treatment synergic integrated tissue adhesive not only has excellent adhesion strength, mechanical bearing capacity and a suitable curing window time, can be adapted to the repair of complex tissue damage sites, but also has biological activity and good compatibility for promoting tissue healing, so that the adhesion fixation, the repair and regeneration of the tissue are effectively realized.

An adhesive composition described herein comprises an aqueous solvent; and a population of first nanoparticles dispersed in the aqueous solvent, the first nanoparticles comprising a negative or positive charge, and an average size in three dimensions of 1 nm to 1000 nm. In some embodiments, a population of second nanoparticles is dispersed in the aqueous solvent, the second nanoparticles comprises a negative or positive charge opposite the charge of the population of first nanoparticles. In some embodiments, the population of first nanoparticles comprise an average first size in three dimensions, and the population of second nanoparticles comprise an average second size in three dimensions that is different from the average first size of the first nanoparticles.

A wound healing composition is provided that includes a tissue adhesive or epithelial tissue healing agent and metal-modified cerium oxide nanoparticles (mCNPs). The nCNPs have a predominant 3+ surface charge and are in a range of about 3-35 nanometers (nm) in size and mixed in an amount that is in a range of about 0.01 to 0.1 weight percentage of a mixture having the tissue adhesive or epithelial tissue healing agent and the mCNPs. The metal (m) is a stable metallic metal with antimicrobial properties and non-ionizing. The mCNPs includes AgCNP2. A method is provided that uses the healing composition to treat a wound or epithelial tissue. The composition can be used to treat the skin or eye and / or subcutaneous tissue.

The present disclosure relates to a medical tissue adhesive for pancreatic plugging and the preparation method and use thereof. The medical tissue adhesive composition forming the medical tissue adhesive of the present disclosure comprises a medical tissue adhesive component and a chelating agent component; wherein the medical tissue adhesive component comprises a first component and a second component, the first component comprises four-arm polyethylene glycol amine, and the second component comprises four-arm-polyethylene glycol-succinimidyl glutarate; wherein m and n are natural numbers; and the chelating agent component comprises polyphenol. The medical tissue adhesive prepared from the medical tissue adhesive composition of the present disclosure is capable of firmly binding to the surface of the pancreatic tissue, and is capable of withstanding the dynamic pressure as a result of pancreatic juice leakage and the enzymatic degradation activity of pancreatic juice. More importantly, the medical tissue adhesive of the present disclosure has an excellent antibacterial ability and is capable of preventing the infection caused by the long-term accumulation of the leaked pancreatic juice.

The invention discloses preparation and application of a proteoglycan colloid material capable of rapidly stopping bleeding and promoting wound healing, and belongs to the field of biological materials. Basic amino acid rich in lysine or arginine is designed and expressed through molecular engineering, and then basic protein and hyaluronic acid with negative electricity are combined through a supramolecular assembly method to prepare a proteoglycan material with antibacterial ability. Then, recombinant mucoprotein rich in tyrosine is designed and expressed, and a DOPA adhesion group is formed through tyrosinase modification, so that the instant adhesion of the tissue adhesion material is enhanced. The amino acid of the basic protein remarkably enhances the interaction of various molecules of proteoglycan, meanwhile, the basic amino acid endows the tissue adhesive with excellent antibacterial ability, and the tissue adhesive provided by the invention has instant tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, and is suitable for being used in the field of medical instruments. The healing of different types of bleeding scenes and irregular wounds is facilitated.

The application discloses a preparation method and application of an injectable high-strength bone tissue adhesive, and belongs to the technical field of biomaterials. The hydrogel tissue adhesive comprises micron or nanometer organic particles carrying amino groups, water-soluble polymer which can be chemically crosslinked with the amino groups, and micron or nanometer inorganic particles which can promote osteogenesis; under the action of water, the hydrogel tissue adhesive can form a continuous and porous particle network, and the chemical reaction between the particles and the polymer can provide good adhesive performance, and the adhesive strength can reach 5Mpa. In addition, the non-covalent interaction between the particles can make the material better stay in the defect site, and realize the filling of the bone defect. The inorganic component in the material component of the application can release ions which can promote osteogenesis, and promote the repair of the bone defect. In addition, the hydrogel tissue adhesive can also be used as a bone wound hemostatic material and a cell scaffold material, and has a wide application prospect in the field of bone repair.

The present invention relates to a biocompatible, tissue adhesive, chitosan flowable dressing, optionally modified with catechol, and suitable for treating bleeding in a physiological environment, e.g., gastrointestinal tract, bladder (in particular in connection with the TURP procedure). The characteristics and structures of the chitosan dressing are provided. Methods of making and using the chitosan dressing are also provided.

The invention provides a high-viscosity anti-swelling tissue adhesive based on a dual-acceptor deep eutectic solvent as well as a preparation method and application of the high-viscosity anti-swelling tissue adhesive. The high-viscosity anti-swelling tissue adhesive is prepared from a part a and a part b, the part a comprises a cycloenone acetal monomer (CKA), an initiator and a cross-linking agent; and the part b comprises an olefin monomer, choline chloride and arginine. The adhesive provided by the invention is an injectable adhesive taking cycloenone acetal, an olefin monomer and a dihydrogen bond acceptor deep eutectic solvent (DES) as cores, choline chloride and arginine are synergistically used as a hydrogen bond acceptor, and the olefin monomer is used as a hydrogen bond donor to construct a high-viscosity DES pre-polymerized solution, so that the in-vivo anti-scouring property is remarkably improved, and the in-vivo anti-scouring property is improved; a hydrophobic network is formed through CKA ring opening polymerization, and long-term swelling resistance and stability are achieved; the adhesive is suitable for closing and bonding wounds in wet environments such as massive hemorrhage wounds, in-vivo wounds, bone tissues and the like. The adhesive also has excellent swelling resistance and tensile property.

The present disclosure relates generally to compositions, systems, and methods for vascular closure, such as upon applying an implantable article to biological tissue and thereby adhering said article to the tissue to which it has been applied. More specifically, the disclosure relates to compositions, systems, and methods that involve articles modified with crosslinkable compositions, the compositions facilitating crosslinking between the article and biological tissue at physiological pH and temperature.

Bioinspired adhesives comprising a macromolecule such as zein and one or more catechol- or gallol-containing compounds are provided. The adhesive can also comprise an iron crosslinker, an interfacial crosslinker, or both an iron crosslinker and an interfacial crosslinker. Methods of manufacturing and using the adhesive are also provided.

The invention relates to the technical field of pharmaceutical preparations, and discloses muscle cooling powder for enhancing swelling caused by exosmosis of a CT (computed tomography) contrast agent and a preparation method thereof.The muscle cooling powder is prepared from amur corktree bark, coptis chinensis, scutellaria baicalensis, rheum officinale, frankincense extract and borneol as active ingredients, a natural deep-eutectic solvent (NADES) generated by reaction of choline chloride and glycerol as a functional solvent, and the skin cooling powder is prepared by mixing the active ingredients and the functional solvent. Polyvinyl alcohol and poloxamer 407 are combined to form a dual polymer matrix, and sodium tetraborate is used as a cross-linking agent. The preparation method comprises the steps of NADES preparation and ultrasonic drug loading, emulsification and solubilization, substrate solution dissolution and dynamic cross-linking molding. According to the invention, the solubility and the transdermal permeability of insoluble drugs are obviously improved through an NADES system; a dynamic boric acid ester bond cross-linked network constructed by boric acid radicals and polyol is utilized to endow the gel with excellent self-healing performance and tissue adhesive force, the problem that the dressing at the joint part is easy to fall off is effectively solved, the forming quality is uniform, and the physical stability is good.

The present invention relates to polysaccharide-based polymeric crosslinkers, polysaccharide-based biomaterials, preparation methods, and uses. In the present invention, the polysaccharide-based polymeric crosslinker is a polysaccharide-based polymeric crosslinker modified with ortho-phthalaldehyde groups, which does not rely on a synthetic hydrophilic polymer backbone or complex chemical synthesis processes. The polysaccharide-based polymeric crosslinker provided by the present invention, together with water-soluble small molecules or polymers containing one or more groups selected from the group consisting of primary amine, hydrazine, hydrazide, hydroxylamine, and mercapto groups, forms a two-component polysaccharide-based hydrogel material in an aqueous medium. This two-component polysaccharide-based hydrogel material has the advantages of being injectable, having low swelling, and having high tissue adhesion. Furthermore, the two-component polysaccharide-based hydrogel material provided by the present invention can be further fabricated into polysaccharide-based biomaterials in the form of membranes, powders, sponges, and other forms, and can be used as tissue adhesives, sealants, hemostats, tissue engineering materials, and other applications, demonstrating its potential for a wide range of biomedical applications.

The invention discloses a macromolecular tissue adhesive for acid-triggered step-by-step adhesion as well as a preparation method and application thereof, and belongs to the technical field of medical macromolecular materials. The polymer tissue adhesive of the present invention comprises an ionized polymer, the ionized polymer is prepared by free radical polymerization of a monomer component in an alkaline aqueous phase, and the monomer component comprises an anhydride-terminated cationic-pi-type amino acid vinyl monomer and a hydroxyalkyl acrylamide monomer. The polymer tissue adhesive disclosed by the invention is dissolved in a water-phase medium to form a precursor solution with excellent flowability, and has endoscope in-situ injection delivery performance; meanwhile, when the precursor solution is in contact with gastric acid, solution-gel conversion can be generated, interface drainage and rapid bonding effects can be achieved, the bonding strength on gastric ulcer wounds can be effectively improved, adjacent cation-pi adhesion units can be formed, long-term stable sealing of ulcer areas is achieved, and the sealing effect is good. And the time of sealing the gastric ulcer wound by the tissue adhesive is prolonged to more than 96 hours.

The present application provides a kind of degradable bio-based tissue adhesive material, which is formed by the one-step polymerization reaction of the light initiation of the complex of degradable amino acid end-capped bio-based supramolecular aqueous polyurethane, acrylic acid or its derivative and plasticizer, to form a transparent tissue adhesive material with double network structure.The adhesive material has the characteristics of instantaneous tissue adhesion, high bonding strength, high mechanical strength and plastic deformation capacity, and is suitable for biomedical fields such as rapid hemostasis of bleeding wounds, rapid closure of damaged wounds and repair of damaged soft tissues.The material also has biodegradability and excellent biocompatibility.In addition, compared with general tissue adhesive materials, the preparation process of the material is simple, the repetition rate is high, and the application range is wider.

The invention relates to the technical field of biomedical materials, in particular to a wet tissue adhesive as well as a preparation method and application thereof, and the wet tissue adhesive comprises hydrogel formed by double decomposition reaction of cationic polysaccharide, anionic polysaccharide, calcium-based powder and polyphosphoric acid organic acid, wherein the calcium-based powder reacts with the polyphosphoric acid organic acid to generate carbon dioxide bubbles for destroying an interface hydration layer and nano-crosslinking enhanced cohesive nano-calcium polyphosphate in situ. By means of efficient water repellency and strong adhesion of in-situ generated carbon dioxide bubbles and nano cross-linking cohesion retention, the mechanical property and the adhesion property are synchronously enhanced, good biocompatibility and degradability are achieved, and the problem of tissue adhesion in a humid environment can be effectively solved.

The invention relates to a mussel mucin tissue adhesive. The mussel mucin tissue adhesive has a two-component system with two-channel chemical crosslinking, enzymatic secondary crosslinking and catechol wet surface adhesion synergism, wherein a component A is PEG active ester, and a component B is recombinant mussel mucin (MAPs) and catechol grafted chitosan (CS-Cat) and is matched with transglutaminase (TGase). The preparation method comprises the following steps of: firstly, carrying out active ester-amine rapid amidation to realize sizing and interface covalent anchoring after mixing under the condition that the pH is approximately equal to 6.9, then forming epsilon-(gamma-glutamyl)-lysine / gamma-glutamyl-amine secondary cross-linking reinforcement by TGase, and meanwhile, providing wet surface multipoint adhesion and energy dissipation by catechol groups of MAPs-DOPA / CS-Cat. The cooperation mechanism faces the comprehensive target of rapid curing, high strength / pressure resistance, washing resistance and good compatibility and stability, and the key shortages in wet surface application in the prior art are overcome.