144 results about "Tissue adhesives" patented technology

The invention discloses a preparation method of a nucleotide tackifying polylipoic acid-based underwater adhesive, and belongs to the field of underwater adhesives. The preparation method comprises the following steps: dissolving three monomers of adenylic acid, lipoic acid and methacryloyloxyethyl trimethyl ammonium chloride in a mixed solution of dimethyl sulfoxide and water, and carrying out a polymerization reaction under a heating condition of 50 DEG C to finally prepare the nucleotide tackifying polylipoic acid-based underwater adhesive. The adhesion property of the lipoic acid polymer is remarkably improved by introducing the adenylic acid monomer. The adhesive prepared by the preparation method disclosed by the invention shows excellent adhesion capacity to various materials (metal, plastic, glass and wood) in a high-humidity environment and an underwater environment, and the underwater adhesion strength can reach 130.47 kPa. According to the invention, high-strength bonding of an adhesive material in an underwater environment is realized, the application range of the adhesive is widened, and the adhesive is expected to be applied to the fields of tissue adhesives, underwater robots, wearable equipment and the like.

The invention discloses a tissue adhesive based on mussel mucin as well as a preparation method and application thereof. The tissue adhesive is prepared from mussel mucin and an anionic compound containing a hydrophobic group, the mussel worm electrostatic self-assembly bionic composite material is developed on the basis of triple bionic principles of dopa adhesion of mussel byssus, electrostatic self-assembly polymerization of sandburg worms and hydrophobic acting force of barnacles. The preparation method of the tissue adhesive is simple, the tissue adhesive can be obtained only by mixing and oscillating the two stock solutions, the gel forming condition is simple and easy to implement, the pH range and the stock solution concentration range required by gel forming are large, the gel forming range is wide, the raw materials required in the preparation process are few, and the cost is low. Only two key raw materials including the mussel mucin and the anionic compound containing the hydrophobic group are needed, and the prepared tissue adhesive is high in adhesion speed and high in adhesion strength, has good cell compatibility and biological safety and can promote wound healing.

The invention discloses a polyphenol-based tissue adhesive for promoting wound healing and a preparation method thereof, and relates to the technical field of medical tissue adhesives. The preparation method of the tissue adhesive comprises the following steps: step 1, preparing a polyphenol compound and recombinant mussel mucin into a solution, and uniformly stirring for later use, namely a solution A; 2, preparing a temperature response type high polymer material into a solution for later use, namely a solution B; and 3, mixing the solution A prepared in the step 1 and the solution B prepared in the step 2, fully and uniformly mixing, shaking and centrifuging, and discarding the supernatant. By selecting the temperature response type high polymer material, the tissue adhesive is endowed with the characteristic of temperature sensitivity, so that the modulus of the adhesive at the human body temperature is improved, and the colloid contraction can further promote wound closure. The mussel mucin is introduced to stimulate collagen regeneration of the wound part, activate the immune mechanism and remodel the wound microenvironment so as to achieve the purpose of promoting healing.

The invention provides a tissue adhesive as well as a preparation method and application thereof, the preparation method specifically comprises the following steps: by adopting a one-pot reaction method, blending and heating biological protein, reducing sugar, a polyphenol unit substance and metal chlorate for reaction to obtain a protein-reducing sugar tissue adhesive with a macromolecular network structure, after the protein-reducing sugar tissue adhesive is subjected to low-temperature incubation, dense and ordered hydrogen bonds are reconstructed in a network structure, and the tissue adhesive is obtained. According to the tissue adhesive provided by the technical scheme of the invention, the tissue adhesive has excellent adhesion characteristics through a synergistic effect of chain enhancement and physical acting force caused by Maillard chemical reaction performed by a one-pot cooking method, so that the tissue adhesive can have modulus and electroactivity matched with natural soft tissues; meanwhile, the hydrogel also has the characteristics of injectability, self-healing capability and quicker and stronger adhesion, can be effectively injected into a nerve injury part, realizes incompressible nerve hemostasis and seamless filling connection of a lesion cavity, and promotes nerve healing and regeneration.

Disclosed is a novel strategy for engineering tissue adhesives in which molecular building blocks are manipulated to allow for precise control and optimization of the various aforementioned properties without any tradeoffs. To introduce tunable mechanical properties and robust tissue adhesion, the hydrogel network presents different modes of covalent and noncovalent interactions using N-hydroxysuccinimide ester (NHS) conjugated alginate (Alg-NHS), poly (ethylene glycol) diacrylate (PEGDA), tannic acid (TA), and Fe3+ ions. Through combining and tuning different molecular interactions and a variety of crosslinking mechanisms, we were able to design an extremely elastic (924%) and tough (4697 kJ / m3) multifunctional hydrogel that could quickly adhere to wet tissue surfaces within 5 sec of gentle pressing and deform to support physiological tissue function over time under wet conditions.

The invention provides a modified polyglutamic acid-based tissue adhesive as well as a preparation method and application thereof. The tissue adhesive is composed of the following components: 1-30 wt% of acidic aldehyde polyglutamic acid; 1 to 15 wt% of a linear protein; 1 to 15 wt% of spherical protein; and the balance of water. The tissue adhesive provided by the invention has the advantages of self-healing performance, low underwater swelling rate and stable adhesion to wet tissues in a physiological environment, and can be applied to rapid hemostasis of dynamic wet tissue wounds in the physiological environment and sealing of wound liquid leakage. Experiments show that the tissue adhesive is high in tissue adhesion stability in a wet physiological environment, and the adhesion strength of the tissue adhesive to wet pigskin tissues can reach 37.4 kPa or above after the tissue adhesive is placed for 12 h under the physiological condition.

The invention discloses a catechol side group-containing polylysine derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) dissolving catechol acid in an organic phase, firstly adding NHS, stirring and dissolving until the materials are uniformly mixed, then adding EDC.HCl, and stirring and reacting to obtain a catechol-NHS intermediate solution; (2) dissolving polylysine or a salt thereof in a water phase, and adjusting the pH value to 6.0-7.0 by using an alkaline solution to obtain a solution of polylysine or a salt thereof; and (3) adding the intermediate solution obtained in the step (1) into the polylysine or the salt solution thereof obtained in the step (2), and maintaining the pH value of the reaction system at 5.0-6.0 by using an alkaline solution to obtain the catechol side group-containing polylysine derivative. The preparation method is short in reaction time and mild in reaction condition, and the obtained product is high in grafting rate and high in raw material conversion rate and has a good application prospect in the aspects of tissue adhesives and the like.

[Problem] To provide an additional use of a polysaccharide derivative such as a tissue adhesive material[Solution] According to some embodiments, a tissue adhesive material is provided, which is intended to be used for a hard and thick tissue and / or a connective tissue and comprises a polysaccharide derivative having such a structure that a group represented by formula (A) is introduced in an acidic, basic or amphoteric polysaccharide. According to some embodiments, a crosslinked structure and a tissue adhesive material comprising the crosslinked structure are provided, in which the crosslinked structure comprises (a) a polysaccharide derivative having such a structure that a group represented by formula (A) is introduced into an acidic, basic or amphoteric polysaccharide and (b) at least one of an amino-group-containing polymer and an amino-group-containing low-molecular-weight compound each containing at least two primary amino groups, hydrazide groups or aminooxy groups and a group represented by formula (x1), and the crosslinking is achieved by the covalent bonding between a primary amino group, a hydrazide group or an aminooxy group contained in the amino-group-containing polymer and the amino-group-containing low-molecular-weight compound and the group represented by formula (A) contained in the polysaccharide derivative through a Schiff base. According to some embodiments, a tissue adhesive material having a gel-like form is provided, which comprises a polysaccharide derivative having such a structure that a group represented by formula (A-2) is introduced into a polysaccharide containing an amino group, in which the group represented by formula (A-2) is introduced into the polysaccharide by substituting for a hydrogen atom in the amino group in the polysaccharide to form an amide bond.

The present disclosure belongs to the field of biomedical materials, and specifically relates to a medical tissue adhesive, and a preparation method therefor and the use thereof, and a composition and a kit for preparing the medical tissue adhesive. According to the medical tissue adhesive provided by the present disclosure, a three-dimensional net-shaped gel skeleton structure is formed by means of the mutual crosslinking of a polyethylene glycol derivative L a polyethylene glycol derivative H and trilysine. Moreover, the gel skeleton has a crosslinked network density and intermolecular interaction that can be improved, and accordingly has an improved structure bonding strength and mechanical strength. In addition, the medical tissue adhesive has the advantages of a reduced swelling rate, a high biocompatibility and biodegradability, can effectively adhere to tissues and seal wounds, reduces compression on tissues such as nerves, realizes wound sealing, tissue repair and blocking of postoperative liquids such as blood and tissue fluid, and has great clinical significance and wide application prospects.

The invention discloses a medical pressure-sensitive adhesive patch based on citric acid, a preparation method and application, the medical pressure-sensitive adhesive patch is composed of an adhesion layer and an anti-adhesion layer, and the thickness ratio of the adhesion layer to the anti-adhesion layer is 1: 1-100: 1; the adhesion layer is obtained by polymerizing a citric acid unit and a polyhydroxy compound unit; the hydrophobic high-molecular polymer is selected from at least one of a polylactic acid-glycolic acid copolymer, polylactic acid, polyurethane and polyether urethane. According to the preparation method, three carboxyl groups in the citric acid not only can be used for esterification reaction with polyhydric alcohols to form a network, but also can provide excellent adhesive force for contact between the adhesive patch and the tissue surface through electrostatic interaction or hydrogen-bond interaction. The anti-sticking layer prepared from the hydrophobic high-molecular polymer can effectively resist invasion of external moisture and bacteria, so that the service time of the adhesive patch is prolonged; meanwhile, the anti-sticking layer can also play a supporting role, so that the mechanical strength of the adhesive tape is improved.

The invention discloses a chitosan / polyurethane biological tissue adhesive and a preparation method thereof. The tissue adhesive provided by the invention mainly comprises two main components, namely catechol grafted chitosan and light-cured waterborne polyurethane. The preparation method comprises the following steps: firstly, grafting a catechol group to chitosan by utilizing Schiff base reaction to prepare modified chitosan, and then preparing double-bond-terminated photocurable waterborne polyurethane from polyol, isocyanate, a small molecular chain extender and an end-capping reagent. And then blending the modified chitosan with light-cured waterborne polyurethane to prepare the chitosan / polyurethane biological tissue adhesive. The prepared biological tissue adhesive has the advantages of favorable underwater adhesion, excellent biocompatibility and degradability, and higher photocuring rate. The adhesive provided by the invention has a wide application prospect in the biomedical field.

The present application relates to the field of medical tissue adhesive, in particular to a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The present application provides a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The medical tissue adhesive provided by the present application comprises: 1wt%-30wt% of acidic polyglutamic acid; 1wt%-30wt% of spherical protein; and the balance of water. The medical tissue adhesive provided by the present application has high tissue adhesion strength and fast hemostatic sealing speed in a wet physiological environment, meets the requirements of rapid and efficient tissue hemostatic sealing, and can be applied to rapid hemostasis of tissue wounds in a wet physiological environment, sealing of wound liquid leakage, healing and repair of wound tissue, and antibacterial of wounds. Experiments show that the dry adhesive patch made of the adhesive provided by the present application has high tissue adhesion strength in a wet physiological environment, and the adhesion strength to a wet pigskin tissue can reach more than 60kPa.

The present invention relates to a tissue adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue reactive polymer, and a tissue adhesive device for sealing the dura mater comprising the tissue adhesive polymer blend.

The present invention discloses an instant-adhesive strong-tough wet tissue tape and a preparation method thereof. The preparation of the instant-adhesive strong-tough wet tissue tape comprises the following steps: S1, reacting 3,4-dihydroxyphenylacetic acid with glycidyl methacrylate to synthesize 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate; S2, dissolving chitosan in an acrylic acid aqueous solution, then adding 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate and a photoinitiator to obtain a mixed solution; S3, applying the mixed solution to the surface of a polymer film treated with a plasma cleaner, and then curing under ultraviolet light to obtain the instant-adhesive strong-tough wet tissue tape. This invention designs and synthesizes novel catechol compounds with long alkyl side chains and uses them to manufacture an instantly adhesive, strong, and resilient wet tissue tape. This tape is thin, flexible, and optically transparent, conforming to various substrates and allowing visual inspection of the substrate's state. Prior to use, the tape is dry and non-sticky, but upon contact with water or blood, it rapidly bonds to wet biological tissue. The tape exhibits exceptionally strong interfacial toughness and adhesion strength to wet biological tissue, far exceeding existing commercial adhesives and some other wet tissue adhesives. Therefore, the instantly adhesive, strong, and resilient wet tissue tape can be used for wound closure and hemostasis.

The present disclosure generally relates to hydrogels, e.g., hydrogels formed by crosslinking. Such hydrogels can provide robust gelation and adhesion, while retaining bioactivity. The hydrogel of the disclosure can be implemented in many applications, for non-limiting example, antifouling and lubricious coatings, tissue adhesives, and wound dressings. The hydrogel offers desirable biocompatibility, bioactivity, biodegradability, and mechanical properties.

The present disclosure relates generally to compositions, systems, and methods for vascular closure, such as upon applying an implantable article to biological tissue and thereby adhering said article to the tissue to which it has been applied. More specifically, the disclosure relates to compositions, systems, and methods that involve articles modified with crosslinkable compositions, the compositions facilitating crosslinking between the article and biological tissue at physiological pH and temperature.

The application discloses a kind of preparation and application of microbial basic protein and adhesive proteoglycan hydrogel, belong to the field of biomaterials.Basic protein is extracted from microbial cells in the present application, using supramolecular assembly method, basic protein and acidic polysaccharide electrostatic assembly protein glycan gel material with strong tissue adhesion, the method is simple, widely available, and the cost is almost negligible.The tissue adhesive provided by the present application has immediate tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, which is beneficial to cope with different types of bleeding scene and irregular wound healing.Through cell compatibility and blood compatibility test, the results show that the material has excellent biocompatibility, and the basic protein has super strong bacteriostatic ability, avoids the invasion of foreign bacteria in the wound repair process, and has strong healing ability, greatly shortens the healing period of wound.

The application relates to the technical field of medical materials, and particularly discloses a kind of bionic medical tissue adhesive and a preparation method thereof.A kind of bionic medical tissue adhesive is made of raw materials containing the following weight parts: alpha-cyano octyl acrylate 30-35 parts;degradable polymer material 20-30 parts;gelatin 1-5 parts;polyethylene glycol 2-5 parts;sterile water 20-30 parts;sodium alginate 2-4 parts;antibacterial agent 8-10 parts;stabilizing protective agent 1-3 parts;mussel extract 1-3 parts;slug extract 1-3 parts;its preparation method is: polyethylene glycol, sterile water, sodium alginate, antibacterial agent, stabilizing protective agent, mussel extract and slug extract are mixed, and stirred uniformly;then alpha-cyano octyl acrylate, degradable polymer material and gelatin are added, heated to 40-60 DEG C and stirred for 20-40 min, and the bionic medical tissue adhesive can be obtained.The bionic medical tissue adhesive of the application can better handle the skin tissue changes occurring in the proliferation period, so that the prominence of the scar formed in the later period is smaller, the whole is relatively flat and smooth, and thus the scar is greatly improved.

The present application relates to a kind of mussel-based composite coacervate based on mussel adhesive protein and its preparation method and purposes, the mussel-based composite coacervate includes mussel adhesive protein and anionic polyelectrolyte material;The mass ratio of mussel adhesive protein and anionic polyelectrolyte material is (0.05~4):1;The oxidation rate of dopa residue in the mussel adhesive protein in the composite coacervate is 0.1%~70.0%.The present application realizes the accurate control of the preparation of the composite coacervate formed by regulating the concentration, mass ratio and system pH of mussel adhesive protein and anionic polyelectrolyte material, and then improves its performance and effect as tissue adhesive, wound repair dressing, acute hemostatic material, local drug delivery carrier and drug release system field or bone tissue repair, cartilage repair and tissue filling and support field.

Provided is a porous sheet having high biocompatibility and adhesive strength, and further having pliability and / or flexibility.　The porous sheet includes: a second gelatin having a hydrocarbon group introduced into a first gelatin; and an unreacted crosslinking agent dispersed in the second gelatin. The second gelatin includes a structure represented by formula (1).

The present invention relates to a method for manufacturing a crosslinked copolymer from at least one CO2-loaded polyamine and at least one polyelectrophilic monomer. The present invention also relates to a porous material consisting of the crosslinked copolymer that can be or is obtained by the claimed method, and to the use thereof in various applications, and in particular as a tissue adhesive foam.

The invention provides a tissue adhesive material as well as a preparation method and application thereof. The tissue bonding material is prepared from the following raw materials: a polymer monomer, wherein the polymer monomer comprises an acrylic monomer and an acrylamide monomer; the modified chitosan compound is obtained by modifying a chitosan compound through a polyphenol compound, and the polyphenol compound has two or more phenolic hydroxyl groups; and an initiator, wherein the initiator comprises a photoinitiator and a radical initiator. When the tissue bonding material is in contact with a wet or wet tissue surface, interface liquid existing between the bonding material and the wet tissue surface can be quickly absorbed and removed, and carboxyl, amido and catechol groups of the tissue bonding material can form a large number of molecular bonds with molecules on the wet tissue surface, so that instant bonding on the wet tissue surface is formed; and high adhesiveness can be maintained for a long time.

The present application relates to the technical field of biological adhesives, and particularly relates to a human tissue adhesive and a preparation method thereof, which comprises the following raw materials: modified polydopamine nanoparticles, sulfonated carbon nanotubes, selenium-calcium phosphate composite nanoparticles (Se-HAp NPs), growth factors, curcumin, quercetin, poly (N-isopropyl acrylamide) and polylactic acid. In the present application, the modified polydopamine nanoparticles significantly improve the wet-state adhesive strength of the adhesive, and the flexible nano-supporting effect of the sulfonated carbon nanotubes synergistically enhances the adhesion and flexibility thereof, and the two form a stable nano-network structure to support the uniform distribution of the Se-HAp NPs, the sulfonated carbon nanotubes ensure the functional integrity of the Se-HAp NPs in a dynamic environment, and the Se-HAp NPs together with the modified polydopamine nanoparticles improve the biological activity and stability of the adhesive, and promote tissue repair, so that the adhesive can adapt to a dynamic tissue environment.

The application discloses a tissue adhesive and a preparation method and application thereof, and belongs to the field of medical materials.The tissue adhesive comprises a copolymer composed of at least one of acrylic acid and methacrylic acid and a hydrochloride salt, the hydrochloride salt is at least one of 2-aminoethyl methacrylic acid ester hydrochloride and 2-aminoethyl acrylic acid ester hydrochloride, and the tissue adhesive can further comprise a crosslinked polymer formed by crosslinking at least one of polyacrylic acid and polymethacrylic acid with a polymer, and the polymer is formed by polymerization of the hydrochloride salt and a zwitterionic betaine.The copolymer can quickly absorb moisture on a wet tissue surface to form a gel and adhere to the tissue surface, so that a soft tissue wound, especially a low-pH microenvironment soft tissue wound, is closed; and the crosslinked polymer can be firmly combined on the surface of the copolymer and quickly form an anti-adhesion gel, which effectively prevents the surrounding tissue from being adhered after an operation as a physical barrier.

This invention relates to a composite tissue adhesive and its application in hemostasis, sterilization, and wound healing promotion. The adhesive comprises component A and component B. Component A includes: methacrylic anhydride-modified gelatin, dodecaldehyde-modified chitosan, polycaprolactone / methacrylic anhydride-modified gelatin blended nanofibers, a photosensitive crosslinking agent, and water. Component B is an aqueous solution of an amino crosslinking agent. In use, components A and B are mixed, injected into the wound, and irradiated with ultraviolet or blue light. The tissue adhesive of this invention is injected directly into the wound site in liquid form. Upon light irradiation, it forms a gel structure in situ with a strength comparable to that of skin, simultaneously providing hemostasis, sterilization, and wound healing promotion.

The present application relates to the technical field of adhesives, and in particular to a medical tissue adhesive and a preparation method thereof. The medical tissue adhesive comprises the following raw materials in parts by weight: 8-12 parts of a polyglutamic acid grafted thermosensitive polymer, 0.8-1.2 parts of vitamin C, 0.8-1.2 parts of sodium periodate, 0-1.2 parts of sodium alginate, 0-1.2 parts of chitosan oligosaccharide, and 2.5-3.5 parts of polyethylene glycol; the polyglutamic acid grafted thermosensitive polymer is prepared by reacting polyglutamic acid and a thermosensitive polymer containing an acid anhydride, and the temperature-sensitive polymer is prepared by copolymerizing an acid anhydride containing a double bond, N-vinyl pyrrolidone, and N-isopropylacrylamide; the medical tissue adhesive has the advantages of improving the hemostatic effect and adhesion of the medical adhesive.

The invention discloses application of alpha-cyanoacrylate n-butyl ester tissue glue in treatment of diverticulum of digestive tract. The tissue glue is used for preparing a medicine for treating the diverticulum of the digestive tract; during treatment, the diverticulum is injected through an endoscope, tissue glue makes contact with tissue fluid to be rapidly polymerized, the diverticulum is sealed, diverticulum complications are prevented, biocompatibility is good, degradation is achieved, no residues exist, the treatment effective rate is 100%, no complications exist, and the recurrence rate is low.

A tissue adhesive for contacting a tissue site, the tissue adhesive comprising: a mixture of natural polymers; and an activating agent enhancing the adhesive properties of the mixture of natural polymers. And a tissue adhesive for contacting a tissue site, the tissue adhesive comprising: a mixture of natural polymers; and an aqueous solution of a water soluble starch or a water soluble starch derivative which forms a gel with the addition of the mixture of natural polymers.

The present disclosure generally relates to hydrogels, e.g., hydrogels formed by crosslinking. Such hydrogels can provide robust gelation and adhesion, while retaining bioactivity. The hydrogel of the disclosure can be implemented in many applications, for non-limiting example, antifouling and lubricious coatings, tissue adhesives, and wound dressings. The hydrogel offers desirable biocompatibility, bioactivity, biodegradability, and mechanical properties.

A process for sterilization of tissue adhesive is provided that includes heating a container containing a quantity of tissue adhesive to maximal temperature of between 180°C and 230°C for a Time Averaged Sterilization Temperature heat flow up to 500,000 C*min / mmol relative to the millimolar quantity of tissue adhesive. The container is cooled to sterilize the cyanoacrylate-based tissue adhesive. A composition of matter results that includes a container with a hermetic seal. A quantity of sterilized tissue adhesive is provided within the container and has storage stability at standard temperature and pressure of at least 36 months.