307 results about "Lipoic acid" patented technology

The invention provides a bio-based adhesive and a preparation method thereof. Inspired by a spider thread structure, biomass adhesive interface enhancement based on a tannic acid adhesion group is combined with construction of a differential phase separation structure by biomass-induced polylipoic acid depolymerization, and a brand new strategy of adhesion-cohesion synergistic enhancement of the adhesive strength of the adhesive is realized. According to the invention, tannic acid and carboxymethyl chitosan are introduced into a lipoic acid-based adhesive, so that the purpose of synergistically enhancing the bonding performance of the adhesive through adhesion-cohesion is achieved, and the defects of weak cohesion, low bonding strength, poor water resistance, poor moisture resistance and the like of the conventional biomass adhesive are overcome. Benefited from a new strategy of adhesion-cohesion synergistic enhancement, the biomass adhesive has good adhesive strength in various environments and materials. In addition, the biomass adhesive also has the characteristics of biological safety, antibacterial and mildew-proof properties and recoverability, so that the product has wider application and potential compared with the previous product, and has a good application prospect.

The invention discloses a feed additive for relieving animal mycotoxin poisoning and a preparation method thereof. The feed additive comprises the following components in parts by weight: 25-30 parts of attapulgite, 25-30 parts of montmorillonite, 25-30 parts of yeast cell walls, 2-5 parts of vitamin E, 5-10 parts of taurine and 5-10 parts of lipoic acid. The feed additive disclosed by the invention can be used for remarkably improving the harm problem of mycotoxin in the livestock and poultry breeding production process and reducing the economic loss of livestock and poultry farmers caused by the mycotoxin pollution of the feed.

The invention discloses a double-crosslinking network hydrogel film for treating oral ulcer, a preparation method and application, and relates to the technical field of biomedical materials. According to the hydrogel film, a dual-network synergistic enhancement structure is constructed through covalent / non-covalent bi-crosslinking, the adhesion to oral mucosa is remarkably enhanced by adopting dopamine (DA) modified hyaluronic acid (HA), and the mechanical property is greatly improved by utilizing a bi-crosslinking network system of disulfide bond / double bond crosslinking (chitosan and CS) and hydrogen bond / catechol self-crosslinking (hyaluronic acid and HA); the antioxidant and anti-inflammatory characteristics of lipoic acid (LA) and the natural antibacterial property of chitosan (CS) are combined to play a synergistic effect, so that the antibacterial and anti-inflammatory effects are remarkably improved. Meanwhile, multifunctional modified materials such as metacrylic acid ester are introduced, so that the functionality and the application range of the hydrogel film are expanded. The preparation technology is optimized, it is ensured that the material is safe and effective, large-scale production is easy, and an efficient and reliable novel material is provided for oral ulcer treatment.

The invention discloses a fermentation medium for regulating and controlling a clostridium aerovorans target product and a fermentation method of the clostridium aerovorans target product. The medium comprises a basic component and a regulating component, the basic components comprise ammonium chloride, potassium chloride, magnesium sulfate heptahydrate, sodium chloride, monopotassium phosphate, yeast powder, calcium chloride dihydrate, sodium selenite, nickel chloride hexahydrate, biotin, folic acid, pyridoxine hydrochloride, thiamine, riboflavin, nicotinic acid, D-calcium pantothenate, cobalamin, para aminobenzoic acid and lipoic acid; the adjusting component comprises sodium tungstate, ferrous sulfate and sodium molybdate, sodium tungstate and ferrous sulfate have a forward adjusting effect on increasing the yield of acetic acid, ethanol and butanol in the target product, and sodium molybdate has a reverse adjusting effect on the target product. By optimizing the proportion of trace elements in the culture medium, the clostridium metabolism efficiency is improved, synthesis of a target product is regulated and controlled, and the method is particularly suitable for industrial production of acetic acid, ethanol, butanol and the like.

The invention belongs to the technical field of adhesives, and particularly relates to a preparation method of a polysaccharide-based reversible bonding adhesive for constructing a dynamic covalent bond network. The preparation method comprises the following steps: by taking lipoic acid and sodium alginate as reactants and ferric chloride as a cross-linking agent, carrying out cross-linking reaction under a stirring condition to obtain a lipoic acid adhesive, namely the polysaccharide-based reversible bonding adhesive. According to the invention, renewable biomass resources such as sodium alginate, hyaluronic acid, chitosan and the like are used as main raw materials, so that the adhesive is expected to replace a traditional synthetic adhesive depending on a petroleum base, accords with a sustainable development strategy, contributes to reducing consumption of fossil resources, avoids release of toxic substances such as formaldehyde and the like in the synthesis and use processes, and has a good application prospect. And the method is more environment-friendly. The bio-based polysaccharide raw material has good biocompatibility and degradability, and an ideal base material is provided for developing a green and safe biomedical adhesive.

The invention provides an adhesive based on a lipoic acid compound and a nitrogen heterocyclic compound as well as a preparation method and application of the adhesive, and belongs to the field of material chemistry. The adhesive disclosed by the invention is prepared from a lipoic acid compound, a nitrogen heterocyclic compound and absolute ethyl alcohol, the azacyclo-compound is at least one of an azacyclo-naphthenic compound or an azacyclo-crown ether compound. The adhesive disclosed by the invention is simple in raw material composition and preparation method, and the obtained adhesive has the advantages of high bonding strength, excellent underwater bonding performance, wide applicable materials, high bonding speed, environment friendliness, recoverable raw materials and the like, and shows huge application potential.

The invention discloses a polylipoic acid-based composite sponge wound dressing and a preparation method and application thereof.The preparation method comprises the following steps that polylipoic acid amide with amino is obtained through disulfide bond ring opening polymerization, and the polylipoic acid amide and an aldehyde cross-linking agent are jointly dissolved in ethyl alcohol to form a solution A; carrying out high-speed shearing, dispersing and foaming on the water-soluble polymer, and freeze-drying to form porous sponge B; the porous sponge B is soaked in the solution A to be subjected to a cross-linking reaction, vacuum drying is conducted, and the polylipoic acid-based composite sponge wound dressing is obtained. The preparation method has the characteristics of simple preparation process, safety and no toxicity, the polylipoic acid with excellent oxidation resistance is introduced into the medical sponge material, the preparation method of the polylipoic acid medical porous structure material is obtained, the oxidation resistance and the wet viscosity of the medical sponge material are improved, and the medical sponge material has good application prospects. The application of the polylipoic acid-based porous material in the fields of hemostatic materials and wound dressings is realized.

The invention discloses a self-repairable lipoic acid-based underwater binder and a preparation method thereof, and relates to the technical field of polymer binders. The binder comprises the following raw material components: lipoic acid and vinyl cyclosiloxane, the lipoic acid and the vinyl cyclosiloxane are subjected to chemical crosslinking through a solvent-free thermal / light synergistic polymerization process, and the underwater binder with good self-repairing performance and binding performance is prepared. The preparation method disclosed by the invention is simple and environment-friendly in process, and the prepared lipoic acid-based underwater binder has firm binding property, good universality and excellent self-repairing characteristic, and can realize rapid and stable binding underwater.

The invention discloses a gelatinized and / or micronized nucleoside drug and a preparation method thereof, and belongs to the technical field of drugs. The preparation method comprises the following steps: mixing lipoic acid, a nucleoside drug and an esterification catalyst, carrying out a grafting reaction in a reaction solvent to obtain a lipoic acid grafted nucleoside drug, dispersing the lipoic acid grafted nucleoside drug in an organic solvent to obtain a dispersion liquid, dropwise adding the dispersion liquid into hot water, and carrying out ring opening polymerization to obtain the lipoic acid grafted nucleoside drug. The nucleoside drug nanogel, nanoparticle or nanofiber is obtained, and the structure and performance improvement based on the drug itself is realized. The gelated and / or micronized nucleoside medicine prepared by the invention has obviously improved scavenging rates of DPPH free radicals and ABTS free radicals, and the method can improve the oxidation resistance of the nucleoside medicine and has the characteristic of improving the stability and functionality of the medicine.

The invention discloses a preparation method of double-coated colloidal sulfur, which comprises the following steps: (1) uniformly dispersing sulfur powder in an Arabic gum solution, and uniformly stirring to obtain a dispersion liquid; carrying out ball milling and filtering on the dispersion liquid to obtain primary wrapped colloidal sulfur; and (2) adding lipoic acid and polyhydric alcohol into the primary coated colloidal sulfur, stirring to react, and freeze-drying and crushing a reaction product to obtain secondary coated colloidal sulfur. The invention also provides the double-coated colloidal sulfur prepared by the preparation method and application of the double-coated colloidal sulfur. According to the preparation method of the double-coated colloidal sulfur, double coating is formed by using physical coating and chemical crosslinking, so that instability of single physical coating is avoided, the stability of the colloidal sulfur can be remarkably improved, and the colloidal sulfur can play a long-acting and stable role.

The invention provides a lipoic acid-based nano-enzyme and a preparation method and application thereof, firstly, lipoic acid is dissolved in an organic solvent by utilizing the amphipathy of the lipoic acid and is self-assembled in water to form a nano-aggregate, and then ring opening polymerization of the lipoic acid is initiated by ultraviolet irradiation to obtain stable lipoic acid nano-particles, namely the lipoic acid-based nano-enzyme. The lipoic acid-based nano-enzyme has the beneficial effects that the preparation method of the lipoic acid-based nano-enzyme prepared by the method is simple, the lipoic acid-based nano-enzyme has stable particle size, good active oxygen scavenging ability and blood brain barrier crossing ability, and in addition, a cavity in the nano-enzyme is suitable for loading hydrophobic bioactive factors and drugs, so that the lipoic acid-based nano-enzyme has a good application prospect. Rich carboxyl groups on the surface of the nano-enzyme can be complexed with various ions, and the nano-enzyme can be applied to treatment of inflammation diseases caused by hypoxia or ischemia and the like and brain drug delivery.

The method comprises the following steps: dissolving lipoic acid and a drug in an organic solvent to form a homogeneous solution, dropwise adding deionized water while stirring, then adding a reducing agent, initiating lipoic acid polymerization and drug co-assembly in situ at 20-40 DEG C to form a drug-loaded micelle solution, and carrying out freeze drying on the drug-loaded micelle solution to obtain the nano-preparation drug based on polylipoic acid. And dialyzing and purifying to obtain the nano preparation medicine based on polylipoic acid. The preparation method is characterized in that lipoic acid has dual characteristics of a drug carrier matrix and a dynamic crosslinking monomer, carrier synthesis and efficient drug encapsulation are synchronously realized through one-step in-situ polymerization-co-assembly, and the technical bottleneck that a traditional nano-carrier needs pre-synthesis and step-by-step drug loading is broken through. The method has the following practicability: (1) the process is simple and efficient, complex equipment is not needed, and reaction conditions are mild; (2) the drug loading performance is excellent, and the particle size is uniform and adjustable (50-300 nanometers); (3) a polylipoic acid skeleton endows the nano-drug preparation with environmental responsiveness, and intelligent drug release can be realized; and (4) the method is suitable for hydrophobic drugs and compound preparations. The method provides a high-load, high-stability and stimuli-responsive nanocrystallization solution for hydrophobic drug delivery, and has application value in the field of nano-medicines.

The invention relates to a method for preparing small-particle-size red nano-selenium particles and application of the small-particle-size red nano-selenium particles, and belongs to the technical field of selenium compounds. The nano-selenium particles contain nano-selenium and a lipoic acid oligomer. The preparation method comprises the following steps: respectively preparing nano-selenium and a lipoic acid oligomer, and uniformly mixing the nano-selenium and the lipoic acid oligomer to obtain the nano-selenium particles. The nano-selenium particles have good stability; the content of total protein and fat in highland barley grains to which the nano-selenium particles are applied is remarkably increased through detection, the nano-selenium particles become an effective means for selenium enrichment of crops, the nano-selenium particles are well applied to selenium-enriched planting of highland barley, and the application of the nano-selenium particles to the highland barley grains is developed by combining development of new selenium-enriched crop varieties and research of a new selenium fertilizer application technology. And a powerful promotion effect is achieved on the development of selenium-enriched ecological agriculture.

The invention relates to the technical field of hyaluronic acid derivatives and nano drug delivery systems, in particular to a lipoic acid grafted hyaluronic acid derivative, a preparation method and application, and provides a lipoic acid grafted hyaluronic acid derivative with a structure that lipoic acid is grafted with hyaluronic acid through a thioketal bond. A lipoic acid grafted hyaluronic acid derivative loaded IAA drug delivery system is constructed, can be gathered at a colitis disease part through intravenous injection, and is actively absorbed by cells by virtue of the affinity effect of hyaluronic acid in a lipoic acid grafted hyaluronic acid derivative structure on CD44 receptors on the surfaces of inflammatory cells; according to the present invention, with the application of the IAA in the cell, the responsive structure degradation occurs in the intracellular high oxidative stress environment, and the IAA is delivered into the cell in the positioning manner, such that the IAA inhibits the inflammation generation by activating the AhR and the downstream oxidative stress and inflammatory reaction related pathway so as to promote the mucous membrane repair, and the problem that the colitis treatment drug cannot accurately act on the focus in the prior art is solved.

The invention relates to an anti-aging capsule compounded by PQQ and mitochondrial nutrients, and discloses an anti-aging capsule which is prepared by synergistically compounding a plurality of mitochondrial nutrients according to a scientific proportion and supplementing high-purity raw materials and slow-release dosage forms to realize energy metabolism activation and anti-oxidation synergistic intervention. Therefore, the anti-aging capsule systematically delays aging through multi-target regulation and control of mitochondrial functions. The capsule is characterized by comprising the following components in parts by weight: 1-20 mg of pyrroloquinoline quinone disodium salt (PQQ), 20-100 mg of coenzyme Q10, 50-200 mg of L-carnitine tartrate, 10-100 mg of alpha-lipoic acid, 50-300 mg of nicotinamide mononucleotide (NMN) or nicotinamide nucleoside (NR), and 10-50 [mu] g of selenoprotein or organic selenium yeast, and a capsule carrier comprises 100 mg of gelatin or a plant-derived capsule shell, 180 mg of microcrystalline cellulose, 5 mg of magnesium stearate and 5 mg of silicon dioxide.

The invention designs a high-performance lipoic acid-based biomass adhesive as well as a preparation method and application thereof, and belongs to the field of bio-based adhesives in high polymer materials. The lipoic acid-based biomass adhesive disclosed by the invention is a light yellow solid and comprises the following raw material components: lipoic acid, a modifying reagent 1 and a modifying reagent 2. The preparation method of the lipoic acid-based biomass adhesive comprises the following steps: dissolving lipoic acid in a proper amount of an organic solvent, adding a modifying reagent 1, uniformly stirring, adding a catalyst 1, and reacting at a certain temperature; and adding a modifying reagent 2 and a catalyst 2 to react to obtain the lipoic acid bio-based adhesive. The lipoic acid-based biomass adhesive disclosed by the invention has the characteristics of environment friendliness, degradability, high bonding strength, convenience in bonding, recyclability, repeated use, complex environment bonding resistance and the like.

The invention provides a bacteriostatic agent aiming at yersinia enterocolitica and application, the bacteriostatic agent comprises a compound solution of lipoic acid and protocatechualdehyde, and when the lipoic acid and the protocatechualdehyde act synergistically, the minimum inhibitory concentrations to the yersinia enterocolitica are 0.625 mg / mL and 0.3125 mg / mL respectively. The yersinia enterocolitica biofilm is inhibited and / or removed through the lipoic acid and protocatechuic aldehyde compound liquid, and the problem that drugs for treating the yersinia enterocolitica infection are prone to drug resistance is solved.

Methods, kits fand photothermal compositions for removing nail coatings are described. The nail coatings include a thermally responsive material, such as thermally expandable microspheres, and a nail product to be removed (e.g. nail polish, gel, dip, nail art, and / or artificial nail. Optionally, a bottom coating, such as lipoic acid, is in contact with the nail surface. The method includes (ii) applying a removal stimulus to a removal layer containing a photothermal additive to induce heat generation and cause at least partial expansion, shape change, and / or phase change of the thermally responsive material or partial detachment of the nail product. Optionally the method includes applying the photothermal nail composition on top of a nail coating prior to step (ii).

An orally administered composition for treating or reducing damage to connective tissue or for treating or reducing inflammatory symptoms associated with damage to connective tissue includes a synergistic combination of (i) avocado / soybean unsaponifiables; and (ii) a lipoic acid or a salt or derivative thereof. A method for treating or reducing damage to connective tissue, for treating or reducing inflammatory symptoms associated with damage to connective tissue, or for reducing the level of one or more inflammatory mediators in connective tissue includes administering the orally administered composition to an avian or mammalian subject.

The utility model provides a high-speed cap screwing machine for lipoic acid capsule packaging, which comprises a bottle body placing structure, the bottle body placing structure comprises a second rotating shaft and a placing bin, the top of the inner wall of the placing bin is provided with a rubber antiskid ring, the outer wall of the placing bin is provided with a positioning strip, and the positioning strip is matched with a fitting strip on the outer wall of a fitting plate at the bottom of a shell. The device is reasonable in design, the fitting plates and the fitting strips are arranged at different positions of the inner wall of the shell, so that the rotating direction of a bottle cap adsorbed in the bottle cap adsorption structure is opposite to that of a bottle body in the bottle body placement structure, the bottle body filled with lipoic acid capsules and the bottle cap can be quickly tightened, and the use is convenient. Therefore, the bottle cap can be quickly installed on the top of the bottle body through the cap screwing machine, and the internal lipoic acid capsule is sealed.

A complex consisting of lipoic acid or a salt thereof, a chelating agent such as a salt of ethylene diamine tetraacetic acid (EDTA) or analogous compounds and an ester of ascorbic acid with long-chain fatty acids, in particular ascorbyl palmitate inhibits the pigmentation of teeth induced by chlorhexidine and salts thereof. In addition to the depigmenting complex, the formulations of the invention, in the form of gels, mouthwashes, toothpastes or periodontal sprays, may contain other ingredients such as hyaluronic acid or hyaluronates, glycerophosphocholine, sweeteners, flavourings, buffering agents, viscosifying agents, mucoadhesive and filming agents, solvents, co-solvents, surfactants.

The application discloses an anti-inflammatory easily-replaced adhesive hydrogel adhesive plaster and a preparation method thereof, relates to the field of biomedical materials, and is a green-prepared hydrogel adhesive plaster based on lipoic acid / hyaluronic acid-g-lipoic acid / cellulose nanocrystals, which has excellent adhesion, tensile property and reusability, and has the abilities of anti-inflammation and promoting wound repair, and can be easily removed through water washing, has the function of being removed on demand, and can be applied to the treatment and healing of first-aid trauma wounds.

This invention relates to a juglansin and lipoic acid conjugate, its preparation method, and its applications. The juglansin and lipoic acid conjugate is named CL-1. CL-1 exhibits significant protective effects in models of oxidative and inflammatory damage in nerve cells, with a significantly greater reduction in TNF-α and IL-6 levels than the monomeric juglansin and lipoic acid, indicating that CL-1 has superior anti-inflammatory and anti-neural damage effects compared to the monomeric drugs, and possesses the potential to treat neurodegenerative diseases such as Alzheimer's disease. The provided preparation method is designed specifically for the structural characteristics of juglansin and lipoic acid, enabling efficient and large-scale synthesis of CL-1.

The present invention provides a biodegradable chitosan-polylipoic acid composite film, a preparation method, and applications, belonging to the technical field of food preservation materials. The chitosan-polylipoic acid composite film is obtained by electrospinning an emulsion containing a chitosan-polylipoic acid complex, a plasticizer, a spinning aid, and cinnamaldehyde. The chitosan-polylipoic acid composite film is biodegradable, has a uniform and controllable structure, and is multifunctional. It has a high encapsulation efficiency, a tight coordination, good antibacterial and antioxidant activity, excellent mechanical properties and gas barrier properties, and can control the release of cinnamaldehyde by responding to changes in pH and humidity in the environment. It has good application prospects in the field of fruit and vegetable preservation.

The application provides a kind of mitochondrial function optimization additive for cell culture, preparation method and application, belongs to cell culture technical field.The additive includes core active ingredient, auxiliary component and carrier, and the core active ingredient includes D-Arg-Cha-Lys-Phe-NH2 Polypeptide, ubiquinone-10 phosphate, reduced glutathione and alpha-lipoic acid.The application forms a multi-target core active system through the synergy of the four, realizes the triple synergistic protection of stabilizing mitochondrial cardiolipin, maintaining mitochondrial morphology and membrane potential, and reducing mitochondrial ROS, which can significantly improve cell culture quality.When applied, the mitochondrial cardiolipin content can be increased by more than 50%, the mitochondrial abnormality ratio can be reduced to less than 12%, the membrane potential positive cell ratio can be increased to more than 86%, the mitochondrial ROS level can be reduced by more than 40%, and the cell proliferation rate can be increased by more than 25%, which is suitable for in vitro culture of various eukaryotic cells, and the preparation process is simple and has no cytotoxicity.

The invention discloses an instant plugging agent as well as a preparation method and application thereof, and belongs to the technical field of biological materials. The instant plugging agent comprises a solution A and a solution B, wherein the solution A is an organic solution containing lipoic acid; the solution B is an aqueous solution containing metal ions. The preparation method comprises the following steps: dissolving lipoic acid in an organic solvent to prepare a solution A; dissolving salt of metal ions in water to prepare a solution B; the application refers to the application in preparation of products for stopping bleeding of human bodies or animal bodies and / or sealing tissue defects. The plugging agent has the characteristic of instant curing, and can tolerate bursting pressure exceeding 450 mm Hg; the device is not only suitable for general wound errhysis, but also can effectively deal with acute hemorrhage and emergency plugging of tissue defects in high-pressure and high-flow-rate states.

The invention provides a preparation method and application of lipid nanoparticles based on lipoic acid derivatives. The lipoic acid derivative provided by the invention depends on a cyclopentane structure and a disulfide bond of lipoic acid, so that a lipid compound is more easily internalized by cells, and the effectiveness of nucleic acid delivery is improved. The lipid nanoparticles have excellent spleen targeting performance, and drugs are preferentially delivered to the spleen.

The invention provides an anti-cancer medicine and food homologous composition and a preparation method thereof. The composition is prepared from the following components in parts by weight: 5 to 10 parts of lipoic acid, 30 to 50 parts of nano curcumin, 2 to 7 parts of berberine, 50 to 100 parts of beta-glucan, 15 to 35 parts of polymethylacrylic acid, 15 to 25 parts of herba hedyotidis diffusae extract, 7 to 15 parts of scutellaria barbata baicalein, 25 to 55 parts of astragalus polysaccharide, 8 to 18 parts of coix seed ester and 10 to 15 parts of cordyceps cicadae. Through a space-time targeting synergistic release mechanism of a bionic nanocellulose skeleton and in combination with pH / enzyme double-response intelligent regulation and control, three-stage precise synergistic effects of oxidation resistance, apoptosis promotion and immune activation are realized, the limitation that a traditional medicinal and edible composition is poor in targeting property, low in synergistic efficiency and uncontrollable in toxicity is broken through, and the medicinal and edible composition has a broad application prospect. High-efficiency and low-toxicity tumor multi-channel synergistic intervention is achieved in a natural component system for the first time, and the actual effect of the whole medicinal and edible composition on cancer and swelling resistance is improved.

The invention relates to the technical field of biological medicines, and discloses an application of N2L in preparation of medicines for preventing and treating obesity and fatty liver, and the N2L is a dimer compound of alpha-lipoic acid and nicotinic acid. According to the embodiment of the invention, the application value of the GPR109A and GLP-1R double-target collaborative strategy in obesity and fatty liver treatment is proposed and verified for the first time, and the small molecule compound N2L with the GPR109A and GLP-1R double-target collaborative strategy can improve muscle endurance while reducing the weight of obese patients and can improve liver fatty degeneration at the same time. The defect that an existing GLP-1R agonist needs to be injected is overcome, meanwhile, the flushing side effect of an existing GPR109A agonist nicotinic acid medicine is avoided, a larger range is provided for medicine selection in the fields of obesity and fatty liver, and meanwhile, the application range of N2L is widened.

This invention discloses a cationic lipid molecule based on lipoic acid derivatives for mRNA delivery, its preparation method, and its uses. The cationic lipid molecule is prepared by reacting lipoic acid with a hydrophilic amine, wherein the hydrophilic amine is one of 4A1, 5A1, or 6A2. The cationic lipid molecule synthesized in this invention contains a protonated nitrogen atom that can bind to negatively charged nucleic acids and form highly stable nanoparticles with polyethyleneimine (PEI), thus improving nucleic acid loading and demonstrating its excellent application in mRNA delivery.