466 results about "Lipoic acid" patented technology

The invention provides a bio-based adhesive and a preparation method thereof. Inspired by a spider thread structure, biomass adhesive interface enhancement based on a tannic acid adhesion group is combined with construction of a differential phase separation structure by biomass-induced polylipoic acid depolymerization, and a brand new strategy of adhesion-cohesion synergistic enhancement of the adhesive strength of the adhesive is realized. According to the invention, tannic acid and carboxymethyl chitosan are introduced into a lipoic acid-based adhesive, so that the purpose of synergistically enhancing the bonding performance of the adhesive through adhesion-cohesion is achieved, and the defects of weak cohesion, low bonding strength, poor water resistance, poor moisture resistance and the like of the conventional biomass adhesive are overcome. Benefited from a new strategy of adhesion-cohesion synergistic enhancement, the biomass adhesive has good adhesive strength in various environments and materials. In addition, the biomass adhesive also has the characteristics of biological safety, antibacterial and mildew-proof properties and recoverability, so that the product has wider application and potential compared with the previous product, and has a good application prospect.

The invention discloses a preparation method of a nucleotide tackifying polylipoic acid-based underwater adhesive, and belongs to the field of underwater adhesives. The preparation method comprises the following steps: dissolving three monomers of adenylic acid, lipoic acid and methacryloyloxyethyl trimethyl ammonium chloride in a mixed solution of dimethyl sulfoxide and water, and carrying out a polymerization reaction under a heating condition of 50 DEG C to finally prepare the nucleotide tackifying polylipoic acid-based underwater adhesive. The adhesion property of the lipoic acid polymer is remarkably improved by introducing the adenylic acid monomer. The adhesive prepared by the preparation method disclosed by the invention shows excellent adhesion capacity to various materials (metal, plastic, glass and wood) in a high-humidity environment and an underwater environment, and the underwater adhesion strength can reach 130.47 kPa. According to the invention, high-strength bonding of an adhesive material in an underwater environment is realized, the application range of the adhesive is widened, and the adhesive is expected to be applied to the fields of tissue adhesives, underwater robots, wearable equipment and the like.

The invention relates to a mussel-like polylipoic acid-based hydrogel adhesive as well as a preparation method and application thereof, and the preparation method comprises the following steps: (1) uniformly mixing a sericin solution and a caffeic acid solution, then carrying out grafting reaction to obtain a reaction solution, and carrying out dialysis treatment and drying on the reaction solution to obtain sericin grafted caffeic acid; (2) adding lipoic acid into the lithium hydroxide solution, stirring until the lipoic acid is completely dissolved, then adding sericin grafted caffeic acid, and heating for reaction to obtain a PTALi-CAS mixture; and (3) cooling the PTALi-CAS mixture, so as to obtain the mussel-like polylipoic acid-based hydrogel adhesive. The dual-network PTALi-CAS hydrogel adhesive obtained in the invention realizes wet adhesion and rapid hemostasis, has excellent comprehensive performance, and is beneficial to providing a good repair environment for wounds as a wound dressing.

The invention provides a hydrogel composition. The hydrogel composition is prepared from the following components in percentage by weight: 0.5 to 15 percent of an adhesion component, 0.5 to 10 percent of a moisturizing component, 0.01 to 5 percent of a bioactive component, 0.01 to 5 percent of a physical crosslinking agent, 0.01 to 2 percent of a flavoring component, 0.01 to 2 percent of an antimicrobial component and the balance of medical purified water, wherein the bioactive component comprises at least one of lipoic acid, tea polyphenol, lactic acid bacteria extract and metabiotics; the antimicrobial component comprises at least one of copper ions, benzyl alcohol, p-hydroxyacetophenone, sodium methyl hydroxybenzoate and sodium ethyl hydroxybenzoate. According to the hydrogel composition disclosed by the invention, the low-concentration antimicrobial component is introduced, so that the antimicrobial component has more stable and effective bactericidal activity and can be more stably adhered to a wound, and the hydrogel composition can have better antibacterial performance and a function of promoting wound healing without additionally adding antibiotics.

The invention discloses a feed additive for relieving animal mycotoxin poisoning and a preparation method thereof. The feed additive comprises the following components in parts by weight: 25-30 parts of attapulgite, 25-30 parts of montmorillonite, 25-30 parts of yeast cell walls, 2-5 parts of vitamin E, 5-10 parts of taurine and 5-10 parts of lipoic acid. The feed additive disclosed by the invention can be used for remarkably improving the harm problem of mycotoxin in the livestock and poultry breeding production process and reducing the economic loss of livestock and poultry farmers caused by the mycotoxin pollution of the feed.

The invention discloses a double-crosslinking network hydrogel film for treating oral ulcer, a preparation method and application, and relates to the technical field of biomedical materials. According to the hydrogel film, a dual-network synergistic enhancement structure is constructed through covalent / non-covalent bi-crosslinking, the adhesion to oral mucosa is remarkably enhanced by adopting dopamine (DA) modified hyaluronic acid (HA), and the mechanical property is greatly improved by utilizing a bi-crosslinking network system of disulfide bond / double bond crosslinking (chitosan and CS) and hydrogen bond / catechol self-crosslinking (hyaluronic acid and HA); the antioxidant and anti-inflammatory characteristics of lipoic acid (LA) and the natural antibacterial property of chitosan (CS) are combined to play a synergistic effect, so that the antibacterial and anti-inflammatory effects are remarkably improved. Meanwhile, multifunctional modified materials such as metacrylic acid ester are introduced, so that the functionality and the application range of the hydrogel film are expanded. The preparation technology is optimized, it is ensured that the material is safe and effective, large-scale production is easy, and an efficient and reliable novel material is provided for oral ulcer treatment.

The invention discloses a fermentation medium for regulating and controlling a clostridium aerovorans target product and a fermentation method of the clostridium aerovorans target product. The medium comprises a basic component and a regulating component, the basic components comprise ammonium chloride, potassium chloride, magnesium sulfate heptahydrate, sodium chloride, monopotassium phosphate, yeast powder, calcium chloride dihydrate, sodium selenite, nickel chloride hexahydrate, biotin, folic acid, pyridoxine hydrochloride, thiamine, riboflavin, nicotinic acid, D-calcium pantothenate, cobalamin, para aminobenzoic acid and lipoic acid; the adjusting component comprises sodium tungstate, ferrous sulfate and sodium molybdate, sodium tungstate and ferrous sulfate have a forward adjusting effect on increasing the yield of acetic acid, ethanol and butanol in the target product, and sodium molybdate has a reverse adjusting effect on the target product. By optimizing the proportion of trace elements in the culture medium, the clostridium metabolism efficiency is improved, synthesis of a target product is regulated and controlled, and the method is particularly suitable for industrial production of acetic acid, ethanol, butanol and the like.

The invention provides a lipid compound based on a lipoic acid derivative, a composition as well as a preparation method and application of the lipid compound. When the lipoic acid-derived lipid provided by the invention is used as a delivery carrier of a nucleic acid drug, because disulfide bonds in the compound are split under the action of glutathione in cells, the compound is degraded, so that the timely release of nucleic acid is triggered, the cytotoxicity caused by accumulation of the compound in the cells is well reduced, and the bioavailability of the nucleic acid drug is improved. The biocompatibility is good. When the lipid nanoparticle composition is used as a carrier to deliver nucleic acid drugs, the lipid nanoparticle composition has excellent delivery efficiency and excellent spleen targeting performance, and the nucleic acid drugs can be preferentially delivered to the spleen.

The invention belongs to the technical field of adhesives, and particularly relates to a preparation method of a polysaccharide-based reversible bonding adhesive for constructing a dynamic covalent bond network. The preparation method comprises the following steps: by taking lipoic acid and sodium alginate as reactants and ferric chloride as a cross-linking agent, carrying out cross-linking reaction under a stirring condition to obtain a lipoic acid adhesive, namely the polysaccharide-based reversible bonding adhesive. According to the invention, renewable biomass resources such as sodium alginate, hyaluronic acid, chitosan and the like are used as main raw materials, so that the adhesive is expected to replace a traditional synthetic adhesive depending on a petroleum base, accords with a sustainable development strategy, contributes to reducing consumption of fossil resources, avoids release of toxic substances such as formaldehyde and the like in the synthesis and use processes, and has a good application prospect. And the method is more environment-friendly. The bio-based polysaccharide raw material has good biocompatibility and degradability, and an ideal base material is provided for developing a green and safe biomedical adhesive.

The invention relates to dithiolane modified beta-cyclodextrin, a preparation method thereof and application of the dithiolane modified beta-cyclodextrin as a drug carrier. The method comprises the following steps: carrying out acylation reaction on beta-cyclodextrin and lipoic acid, and modifying different numbers of dithiolane on the beta-cyclodextrin by changing a feeding ratio; the beta-cyclodextrin has a plurality of hydroxyl groups, and the activity of the hydroxyl groups at the C6 position is relatively high. The hydrophobic cavity of the dithiolane-modified beta-cyclodextrin can be loaded with a hydrophobic small-molecule drug, and the hydrophobic small-molecule drug can be loaded into the dithiolane-modified beta-cyclodextrin under the condition of heating reflux to form a nano-drug. The disulfide bond on the surface of the nano-drug and sulfydryl on protein or lipid on the outer side of a cell membrane are subjected to dynamic covalent thiol exchange, so that the nano-drug enters cells through a thiol-mediated cellular uptake way, endosomes and lysosomes can be avoided, the drug is quickly and directly delivered to the cytoplasm, degradation of the drug in the lysosomes is reduced, and the drug delivery efficiency is improved. The utilization rate of small-molecule drugs is improved, side effects are reduced, and better curative effects are achieved.

The invention provides an adhesive based on a lipoic acid compound and a nitrogen heterocyclic compound as well as a preparation method and application of the adhesive, and belongs to the field of material chemistry. The adhesive disclosed by the invention is prepared from a lipoic acid compound, a nitrogen heterocyclic compound and absolute ethyl alcohol, the azacyclo-compound is at least one of an azacyclo-naphthenic compound or an azacyclo-crown ether compound. The adhesive disclosed by the invention is simple in raw material composition and preparation method, and the obtained adhesive has the advantages of high bonding strength, excellent underwater bonding performance, wide applicable materials, high bonding speed, environment friendliness, recoverable raw materials and the like, and shows huge application potential.

The invention discloses a method for detecting a chiral isomer of 6-hydroxy-8-chloro ethyl caprylate. The method comprises the following steps: carrying out gas chromatography detection on a test solution containing R-6-hydroxy-8-chloro ethyl caprylate and S-6-hydroxy-8-chloro ethyl caprylate, wherein the gas chromatography detection is carried out on the test solution containing R-6-hydroxy-8-chloro ethyl caprylate and S-6-hydroxy-8-chloro ethyl caprylate; the conditions of the gas chromatography detection are as follows: a chromatographic column is selected from a chiral chromatographic column containing beta-cyclodextrin; the chromatographic column adopts programmed heating in the detection process, the initial column temperature is 120-180 DEG C, the final column temperature is 190-220 DEG C, and the heating rate is 0.5-2.0 DEG C / min. The method is based on a gas chromatographic method, adopts a beta-cyclodextrin-containing chiral chromatographic column, and is combined with programmed heating at a specific initial column temperature heating rate, so that the two chiral isomers of 6-hydroxy-8-chloro ethyl caprylate can be separated and detected, the sensitivity is high, the specificity is good, and the separation degree meets the standard; the method has important significance on preparation of single-configuration lipoic acid.

The invention discloses a curcumin-loaded brain-targeted drug delivery system as well as a preparation method and application thereof. The delivery system comprises a carrier macrophage and a curcumin drug, the curcumin nano-drug is prepared by encapsulating curcumin with a lipoic acid modified cyclodextrin conjugate, then macrophages and the curcumin nano-drug are mixed, and co-incubation is carried out, so that the curcumin nano-drug is constructed. The brain-targeted macrophage drug delivery system loaded with curcumin is a multifunctional composite drug with brain targeting property for treatment of cerebral arterial thrombosis. A brain-targeted macrophage drug delivery system loaded with the curcumin nano-drug gathers in cerebral apoplexy tissues, phenotypic transformation of inflammatory microglial cells is promoted, and a pro-inflammatory microenvironment is improved; the oxidative stress pressure of the stroke part is improved; the two effects promote each other, the stroke microenvironment is improved, the functions of neuronal cells are saved, the synergistic nerve protection effect can be achieved in the aspect of treating ischemic cerebral apoplexy, and potential safety hazards are reduced.

The preparation method specifically comprises the following steps: sequentially adding arginine and lipoic acid into a gelatin solution to obtain a hydrogel pre-polymerized solution; heating the hydrogel prepolymerization liquid to initiate a lipoic acid ring-opening polymerization cross-linking reaction, and adding a poly (3, 4-ethylenedioxythiophene) dispersion liquid modified by polydopamine to obtain gelatin / polylipoic acid conductive hydrogel; the preparation method comprises the following steps: heating and melting a lipoic acid monomer, then adding a cross-linking agent for reaction, then adding metal salt for stirring, and pouring the obtained yellow transparent liquid on the surface of the gelatin / polylipoic acid conductive hydrogel to obtain the double-layer heterogeneous biological adhesive. The invention also discloses an application of the double-layer heterogeneous biological adhesive in a biomedical adhesive. According to the method, strong interface connection between the two layers is achieved through the similar compatibility principle and the hot melting pouring technology, and layering is avoided during use; and the prepared adhesive has good tissue adhesion, self-repairing performance and biocompatibility.

The invention discloses a polylipoic acid-based composite sponge wound dressing and a preparation method and application thereof.The preparation method comprises the following steps that polylipoic acid amide with amino is obtained through disulfide bond ring opening polymerization, and the polylipoic acid amide and an aldehyde cross-linking agent are jointly dissolved in ethyl alcohol to form a solution A; carrying out high-speed shearing, dispersing and foaming on the water-soluble polymer, and freeze-drying to form porous sponge B; the porous sponge B is soaked in the solution A to be subjected to a cross-linking reaction, vacuum drying is conducted, and the polylipoic acid-based composite sponge wound dressing is obtained. The preparation method has the characteristics of simple preparation process, safety and no toxicity, the polylipoic acid with excellent oxidation resistance is introduced into the medical sponge material, the preparation method of the polylipoic acid medical porous structure material is obtained, the oxidation resistance and the wet viscosity of the medical sponge material are improved, and the medical sponge material has good application prospects. The application of the polylipoic acid-based porous material in the fields of hemostatic materials and wound dressings is realized.

The invention discloses a satiety sugar-controlling fat-reducing composition and a preparation method and application thereof, the satiety sugar-controlling fat-reducing composition comprises hydrogel particles, a white kidney bean extract, a mulberry leaf extract, alpha-lipoic acid, L-carnitine, a lotus leaf extract, medium chain triglyceride, polyethylene glycol and sorbitol, and the composition is a tablet. The components are matched with one another to effectively adjust the leptin level, improve appetite, increase energy consumption, adjust the fat metabolism process, reduce fat accumulation, improve fat consumption, inhibit the activity of alpha-amylase, reduce the conversion of carbohydrates into fat, block heat and fat intake, promote gastrointestinal motility and enhance the immunity of the human body. The effects of remarkably reducing the fat content and the body weight are achieved.

The invention discloses equipment for preparing lipoic acid particles, and belongs to the field of lipoic acid preparation.The equipment comprises a tank body, an upper cover is fixedly connected to the upper surface of the tank body, a feeding port is connected to one side of the upper surface of the upper cover, a discharging port is connected to the lower surface of the tank body, and an evaporation bin is fixedly connected to the middle of the inner surface of the tank body; second electromagnetic valves are symmetrically and fixedly connected to the lower surface of the evaporation bin, a stirring assembly used for stirring raw materials is connected to the upper surface of the upper cover, and a drying assembly used for drying the raw materials is connected to the position, close to the lower surface, of the outer surface of the tank body. The swing blades can continuously swing left and right in the dissolving frame, so that a solution in the dissolving frame is stirred in different directions, the solution forms turbulent flow in the dissolving frame, lipoic acid powder moves irregularly and is fully fused with the solution, the dissolving speed of the powder is increased, and compared with an existing stirring mode, the stirring efficiency is improved. Stirring and dissolving time is short, and working efficiency is high.

The invention discloses a self-repairable lipoic acid-based underwater binder and a preparation method thereof, and relates to the technical field of polymer binders. The binder comprises the following raw material components: lipoic acid and vinyl cyclosiloxane, the lipoic acid and the vinyl cyclosiloxane are subjected to chemical crosslinking through a solvent-free thermal / light synergistic polymerization process, and the underwater binder with good self-repairing performance and binding performance is prepared. The preparation method disclosed by the invention is simple and environment-friendly in process, and the prepared lipoic acid-based underwater binder has firm binding property, good universality and excellent self-repairing characteristic, and can realize rapid and stable binding underwater.

The invention discloses a hot-melt injectable adhesive as well as a preparation method and application thereof, and belongs to the technical field of adhesives. The hot-melt injectable adhesive provided by the invention contains a co-hot-melt product of alpha-lipoic acid, N-alkane lipoic amide and tris (2-carbonyl ethyl) phosphorus hydrochloride or citric acid, and specifically, the hot-melt adhesive is formed by cooling after the alpha-lipoic acid, the N-alkane lipoic amide and the tris (2-carbonyl ethyl) phosphorus hydrochloride or citric acid are subjected to mixing and hot melting. The hot-melt injectable adhesive provided by the invention adopts a temperature-responsive crystallization curing mode, the curing process does not involve substance exchange with a water phase, and the use of a solvent is omitted, so that the hot-melt injectable adhesive has the advantages of being green and environment-friendly, simple to prepare, good in universality, strong in adhesive force, convenient to use and easy to operate; the method is expected to show huge application potential in the fields of daily life and industrial engineering.

The invention discloses an absorbable tissue adhesion material, a preparation method thereof and an application of the absorbable tissue adhesion material in preparation of a body solid material, a coating material or an injectable liquid material. The preparation method comprises the following steps: heating lipoic acid monomer powder to carry out polymerization reaction, and carrying out ultraviolet polymerization on the obtained polymer in a solution in the presence or absence of polyphenol to obtain a lipoic acid polymer which can absorb the tissue adhesion material, the ultraviolet light intensity of the ultraviolet light polymerization is 20-100W / cm < 2 >, and the ultraviolet light wave band is 250-500nm. The absorbable tissue adhesion material disclosed by the invention is a degradable polymer material with excellent tissue adhesion and anti-inflammatory and anti-oxidation characteristics.

The invention provides a blood purification adsorbent and a preparation method thereof, the blood purification adsorbent takes macroporous resin containing an epoxy group as a carrier, the epoxy group on the carrier reacts with polyethyleneimine, the polyethyleneimine is immobilized on the carrier, the polyethyleneimine is taken as a spacer arm, and the epoxy group on the carrier reacts with the polyethyleneimine to prepare the blood purification adsorbent. Superoxide dismutase and lipoic acid are connected to the spacer arm through a dehydration condensation reaction, so that the superoxide dismutase and the lipoic acid are immobilized on the carrier. The blood purification adsorbent can remove superoxide, free radicals and inflammatory factors at the same time, and can effectively improve oxidative stress and microinflammation states.

The invention discloses a gelatinized and / or micronized nucleoside drug and a preparation method thereof, and belongs to the technical field of drugs. The preparation method comprises the following steps: mixing lipoic acid, a nucleoside drug and an esterification catalyst, carrying out a grafting reaction in a reaction solvent to obtain a lipoic acid grafted nucleoside drug, dispersing the lipoic acid grafted nucleoside drug in an organic solvent to obtain a dispersion liquid, dropwise adding the dispersion liquid into hot water, and carrying out ring opening polymerization to obtain the lipoic acid grafted nucleoside drug. The nucleoside drug nanogel, nanoparticle or nanofiber is obtained, and the structure and performance improvement based on the drug itself is realized. The gelated and / or micronized nucleoside medicine prepared by the invention has obviously improved scavenging rates of DPPH free radicals and ABTS free radicals, and the method can improve the oxidation resistance of the nucleoside medicine and has the characteristic of improving the stability and functionality of the medicine.

The invention discloses a preparation method of double-coated colloidal sulfur, which comprises the following steps: (1) uniformly dispersing sulfur powder in an Arabic gum solution, and uniformly stirring to obtain a dispersion liquid; carrying out ball milling and filtering on the dispersion liquid to obtain primary wrapped colloidal sulfur; and (2) adding lipoic acid and polyhydric alcohol into the primary coated colloidal sulfur, stirring to react, and freeze-drying and crushing a reaction product to obtain secondary coated colloidal sulfur. The invention also provides the double-coated colloidal sulfur prepared by the preparation method and application of the double-coated colloidal sulfur. According to the preparation method of the double-coated colloidal sulfur, double coating is formed by using physical coating and chemical crosslinking, so that instability of single physical coating is avoided, the stability of the colloidal sulfur can be remarkably improved, and the colloidal sulfur can play a long-acting and stable role.

The present invention describes a composition comprising an effective amount of a combination of two or more components selected from acacetin, ACT1 peptide, α-lipoic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, β-lapachone, β-hydroxy-β-methylbutyrate, bacopa monnieri, catechins, catechols, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (-)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-α-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercetin (EMIQ), shan Phosphate, black bean anthocyanins, leucine, lithium, luteolin, luteolin, luteolin, melatonin, menadione, 1‑methylnicotinamide (MNA), methyl salicylate, myricetin, nicotinamide adenine dinucleotide, nicotinic acid (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid mononucleotide (NaMN), parsley, phenylephrine, pokeweed mitogen, 15‑Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxerutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin, and zinc (including its salts).

The invention provides a lipoic acid-based nano-enzyme and a preparation method and application thereof, firstly, lipoic acid is dissolved in an organic solvent by utilizing the amphipathy of the lipoic acid and is self-assembled in water to form a nano-aggregate, and then ring opening polymerization of the lipoic acid is initiated by ultraviolet irradiation to obtain stable lipoic acid nano-particles, namely the lipoic acid-based nano-enzyme. The lipoic acid-based nano-enzyme has the beneficial effects that the preparation method of the lipoic acid-based nano-enzyme prepared by the method is simple, the lipoic acid-based nano-enzyme has stable particle size, good active oxygen scavenging ability and blood brain barrier crossing ability, and in addition, a cavity in the nano-enzyme is suitable for loading hydrophobic bioactive factors and drugs, so that the lipoic acid-based nano-enzyme has a good application prospect. Rich carboxyl groups on the surface of the nano-enzyme can be complexed with various ions, and the nano-enzyme can be applied to treatment of inflammation diseases caused by hypoxia or ischemia and the like and brain drug delivery.

The invention discloses a lipoic acid pharmaceutical composition and a preparation method thereof, the form of the pharmaceutical composition is wet particles, and the pharmaceutical composition comprises lipoic acid, hydroxy propyl cellulose and an ethanol aqueous solution; the preparation method comprises the following steps: adding an ethanol aqueous solution of hydroxy propyl cellulose into a lipoic acid-containing mixed material, carrying out wet granulation, and controlling the concentration of the ethanol aqueous solution to be 20-60%, the problems of sticking and cracking in the tabletting process are avoided, and process feasibility is achieved; moreover, the dosage of the ethanol aqueous solution of the hydroxy propyl cellulose is only 15-30% of the mass of the lipoic acid, so that the problem of difficult particle drying caused by excessive wetting is avoided, and industrial production is facilitated.

The method comprises the following steps: dissolving lipoic acid and a drug in an organic solvent to form a homogeneous solution, dropwise adding deionized water while stirring, then adding a reducing agent, initiating lipoic acid polymerization and drug co-assembly in situ at 20-40 DEG C to form a drug-loaded micelle solution, and carrying out freeze drying on the drug-loaded micelle solution to obtain the nano-preparation drug based on polylipoic acid. And dialyzing and purifying to obtain the nano preparation medicine based on polylipoic acid. The preparation method is characterized in that lipoic acid has dual characteristics of a drug carrier matrix and a dynamic crosslinking monomer, carrier synthesis and efficient drug encapsulation are synchronously realized through one-step in-situ polymerization-co-assembly, and the technical bottleneck that a traditional nano-carrier needs pre-synthesis and step-by-step drug loading is broken through. The method has the following practicability: (1) the process is simple and efficient, complex equipment is not needed, and reaction conditions are mild; (2) the drug loading performance is excellent, and the particle size is uniform and adjustable (50-300 nanometers); (3) a polylipoic acid skeleton endows the nano-drug preparation with environmental responsiveness, and intelligent drug release can be realized; and (4) the method is suitable for hydrophobic drugs and compound preparations. The method provides a high-load, high-stability and stimuli-responsive nanocrystallization solution for hydrophobic drug delivery, and has application value in the field of nano-medicines.

The invention belongs to the technical field of poultry feed additives, provides a feed additive for improving growth and skeleton health of broiler chickens in a chronic stress state and application of the feed additive, and particularly relates to new application of the feed additive in broiler chicken feed additives with high-density stress and heat stress. And the used lipoic acid and chromium methionine are safe, free of drug resistance, free of adverse reaction and low in price. The feed additive comprises lipoic acid and chromium methionine, and the addition amount of the lipoic acid is 300mg / kg; and chromium methionine is 400 [mu] g / kg. The additive can influence the bone quality and improve the bone breaking strength, the bone-body ratio and the weight of the heat stress broiler chicken. The additive can improve the immune organ index of the broiler chicken and improve the relative weight of spleen, thymus and abdominal fat. The feed additive can improve the oxidation resistance and immune performance of the broiler chickens under high-density stress and heat stress, relieve bone injury, and possibly protect bone health of the broiler chickens by removing free radicals in the body and maintaining calcium and phosphorus metabolic balance in the body.

The invention provides two-dimensional bimetal organic framework nano-enzyme hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological materials. According to the preparation method, a FeCuMOF bimetal organic framework is adopted as a nano-enzyme, tannic acid and lipoic acid are used for constructing a composite hydrogel system with antibacterial and antioxidant capacities, and the composite hydrogel is combined with FeCuMOF to form the two-dimensional bimetal organic framework nano-enzyme hydrogel. The two-dimensional bimetal organic framework nano-enzyme hydrogel disclosed by the invention has antibacterial and anti-biofilm properties, and can be used for removing various ROS (Reactive Oxygen Species) by simulating superoxide dismutase and the capability of removing ABTS free radicals thereof. In addition, proinflammatory cytokines can be reduced, and anti-inflammatory cytokines can be increased, so that periodontitis inflammation is relieved, and tissue regeneration is accelerated. The two-dimensional bimetal organic framework nano-enzyme hydrogel disclosed by the invention is used as a multifunctional nano-enzyme hydrogel slow-release platform, and an ideal strategy is provided for treating periodontitis.

The invention relates to a method for preparing small-particle-size red nano-selenium particles and application of the small-particle-size red nano-selenium particles, and belongs to the technical field of selenium compounds. The nano-selenium particles contain nano-selenium and a lipoic acid oligomer. The preparation method comprises the following steps: respectively preparing nano-selenium and a lipoic acid oligomer, and uniformly mixing the nano-selenium and the lipoic acid oligomer to obtain the nano-selenium particles. The nano-selenium particles have good stability; the content of total protein and fat in highland barley grains to which the nano-selenium particles are applied is remarkably increased through detection, the nano-selenium particles become an effective means for selenium enrichment of crops, the nano-selenium particles are well applied to selenium-enriched planting of highland barley, and the application of the nano-selenium particles to the highland barley grains is developed by combining development of new selenium-enriched crop varieties and research of a new selenium fertilizer application technology. And a powerful promotion effect is achieved on the development of selenium-enriched ecological agriculture.