1520 results about "Berberine" patented technology

Berberine or pharmaceutically acceptable salts thereof either alone or in combination with cyclosporin can be used to treat or prevent graft vs. host disease. Berberine or pharmaceutically acceptable salts thereof can also be used to treat or prevent septic shock syndrome.

The invention relates to a general-purpose composite Chinese herbal medicine immune enhancer for freshwater cultured fish, which is made of raw materials with the following weight ratios, based on the amount added per ton of feed: rhubarb 800-2000g; Sanqi 350-1000g; water Silybum 1200-2500g; Cassia 600-800g; Astragalus 600-2000g; Scutellaria baicalensis 500-900g; 500-1500g; Garlic 1000-2000g. After many tests in the laboratory, it has been proved that the general-purpose compound Chinese herbal medicine immune enhancer for freshwater aquaculture fish can improve the survival rate of a variety of freshwater aquaculture fish in the process of attacking viruses; The long-term breeding experiment of farmed fish feed proves that the general-purpose compound Chinese herbal medicine immune enhancer for freshwater farmed fish can effectively reduce the incidence of a variety of high-density farmed freshwater fish and improve the survival of the breed; the additive is safe, efficient, and has no side effects for long-term use. The breeding objects have strong vitality, rapid growth, bright body color, high feed conversion rate, and good breeding benefits.

This invention relates to new safe natural drug, which is prevention of cancer and control of cancer cells. Specifically, this invention provides methods for producing of Berberine and Baicalin.Also, the present invention proved a new radioimmunoassay (RIA) method for precise determination of Berberine and Baicalin. The RIA is an efficient analytical method for large clinical programs including double blind analysis (DBA), and good clinical practice (GCP).

The present invention relates to a composition for preventing at least one plant disease resulted from infection of plant pathogens and a method for preparing the same. Particularly, the composition contains extract of at least one plant selected from the group consisting of Coptis chinensis Franch., Phellodendron genus plant, Sanguinaria canadensis and Chelidonium majus var. asiaticum which are natural plants having anti-plant pathogen activity or berberine which is purified therefrom. The composition of the present invention can be effectively used for preventing disease pathogens such as plant powdery mildew, anthracnose of pepper, damping-off of cucumber and gray mold rot of strawberry resulted from infection of plant pathogens such as Colletrotrichum gloeosporiodes, Pythium ultimum or Botrytis cinerea. For an alternative method for preparing the composition comprising berberine and/or derivatives thereof, the present invention provides various optimal culture condition and two phases cultivation methods using Phellodendron genus plant.

The invention discloses a traditional Chinese medicine preparation for enhancing the immunity of pigs and poultry, which comprises 10-30 parts of atractylodes rhizome, 10-20 parts of licorice, 10-50 parts of American ginseng, 10-30 parts of bupleurum, 10-30 parts of kudzu root and 10-30 parts of Cimicifuga 20. Peony 10-20, Jianqu 10-30, Rhubarb 10-40, Magnolia officinalis 10-20, Citrus aurantium 10-30, Betel nut 10-20, Qinpi 10-20, Glauber's salt 10-40, Coptis 10-30, Scutellaria baicalensis 10-30, Folium 10-20, Pulsatilla 10-40. The present invention can be applied to the entire breeding and epidemic prevention process of pigs and poultry, without using any vaccines, antibiotics, hormones and other chemical drugs at all, only using traditional Chinese medicine to enhance immunity, and finally making the meat products of pigs and poultry produced without antibiotics and hormones Green food such as chemicals.

A method of treating non-insulin dependent diabetes mellitus comprising the step of providing a composition comprising a predetermined amount of berberine and a predetermined amount of catalpol, wherein said berberine and said catalpol are major active ingredients of said composition. The composition may further comprise a predetermined amount of oleanolic acid as another active ingredient. The berberine is obtained from natural herbs selected from the group of Berberis, Chelidonium, Stephniz, Coptis, Phellodendron, and Ziziphus, the catalpol is obtained from natural herbs selected from the group of Rehmannia, Verbascum, Panulownia, Glubularia and Adonis, and the oleanolic acid is obtained from natural herbs selected from the group of Olea, Swertia, Astrantia, Lonicera and Beta.

The invention relates to novel application of berberine and derivatives thereof in preparation of medicines, in particular to application of berberine and derivatives thereof in preparation of indole amine 2, 3-dioxygenase IDO inhibitor, belonging to the medicine field. According to IDO inhibition activity detection, reversible inhibition judgment, inhibitor type judgment, Ki value determination and median effective inhibition concentration IC50 determination, the results show that berberine is reversible inhibitor and inhibition constant Ki is 8muM; and jatrorrhizine hydrochloride and palmatine hydrochloride are irreversible inhibitors, and the median effective inhibition concentrations IC50 thereof are respectively 123muM and 126muM. When the berberine and the derivatives thereof disclosed in the invention are used as IDO inhibitors, the application prospect is wide and the IDO inhibitors can be used for treating serious diseases such as cancers, AIDS, Alzheimer diseases, tristimania, cataract and the like with pathological feature of IDO-mediated tryptophan metabolism.

The present invention relates to one kind of mangiferin-berberine composition with relatively high water solubility and its preparation process and medicinal application. The mangiferin-berberine composition has water solubility up to 25 mg/ml. Animal test shows that the mangiferin-berberine composition has functions of inhibiting bacteria, lowering blood sugar, diminishing inflammation, protecting liver, etc. The mangiferin-berberine composition may be used in preparing eye drops, medicine for women's vaginal diseases, medicine for lowering blood sugar and medicine for treating hepatitis.

The invention discloses a berberine electrostatic composite and a preparation method of the berberine electrostatic composite, which are applied to medical and health industries. The berberine electrostatic composite is prepared from anionic surfactant and berberine or berberine salt by compositing; the molar ratio of the anionic surfactant to the berberine or berberine salt is 1 to 0.5-10; the molar ratio of anion to the berberine salt is 1 to 1; the anionic surfactant is one or more of alkyl sulfate or alkyl sulfonate or fatty acid salt; the alkyl sulfate is one or more of sodium cholesteryl sulfate, lauryl sodium sulfate and deoxysodium cholate; the alkyl sulfonate is one or more of sodium heptanesulfonate and sodium dodecyl sulfate; the fatty acid salt is one or more of sodium caprate and sodium enanthate, and the berberine and berberine salt are obtained by chemical synthesis or by extracting traditional Chinese medicine. The berberine is prepared into the berberine electrostatic composite to increase the biological membrane penetrating ability of the berberine and improve the oral bioavailability of the berberine, and the berberine electrostatic composite plays a significant treatment role on important chronic metabolic disorder diseases such as diabetes mellitus, complication of the diabetes mellitus, hyperlipidemia and the like.

The invention discloses a broad-spectrum bactericide of a plant source. The broad-spectrum bactericide of the plant source comprises the raw materials by weight percentage as follows: 0.5-4.5% of berberine, 0.5-20% of astragalus polysaccharide, 0.5-20% of radix tetrastigme extract, 0.5-20% of aloe extract, 0.5-20% of saponins and the balance of water. The broad-spectrum bactericide of the plant source generated after compounding the plant extracts extracted from pure plants has the advantages of efficiency, low cost, environment-friendliness, difficulty to generate drug resistance and innocuity to people and livestock.

An agricultural chemical composition for controlling pests including armyworm and bacteria contains berberine (0.5-2.5%) and matrine (0.1-2.0%). Its advantages are high effect, no environmental pollution, and low toxicity to people and livestock.

Methods and composition for treating or preventing an inflammatory dermatological disease or condition, such as psoriasis, in a subject are described. The methods involve topical applications to the subject a therapeutically effective amount of a composition comprising at least one indigo naturalis composition, beberine and a pharmaceutically acceptable carrier.

The invention relates to a berberine plant source insecticide and a preparation method thereof. The insecticide comprises the following raw materials in parts by weight: 40-50 parts of berberis root, 1-2 parts of phellodendron bark, 45-50 parts of purple common perilla and 2-3 parts of castor. The berberine plant source insecticide takes berberine in the berberis root and phellodendron bark as the insecticidal active component; and since berberine has photoactive toxicity for pests, and the toxicity of the berberine plant extract for pests is enhanced when the berberine plant extract is degraded under the activation of light, the invention enhances the drug effect of insecticide, prevents enduring residence in the environment and conforms to environment concordance required by no-pollution pesticides. The product of the invention has the advantages of no toxicity, no residue, wide materials sources and low production cost, has the effects of anesthetization, contact killing, stomach toxicity, systemic action and the like, has favorable integrated control effects of disinsection and bacteriostasis, can be widely used in the fields of agriculture, forestry, animal husbandry and the like, and is especially suitable for production of traditional Chinese medicinal materials, organic food, green food and no-pollution food.

The invention belongs to the technical field of pesticide application, and relates to new application of berberine, in particular to new application of berberine serving as an agricultural fungicide. The new application refers to preventing and controlling plant diseases caused by plant pathogenic bacteria. Studies show that berberine has good inhibiting effect on various plant pathogenic bacteria, and a theoretic foundation is laid for developing berberine into a new pesticide.

The invention provides a berberine organic acid salt, a berberine organic acid salt inclusion compound and preparations method thereof. The berberine organic acid salt consists of an alkali base and a salt ligand, wherein the alkali base is a jamaicin alkali base; the salt ligand is an acid radical of organic acid; the mole ratio of the alkali base to the acid radical of organic acid is 1:1; and the berberine organic acid salt inclusion compound consists of an inclusion base material and the berberine organic acid salt. The method for preparing the berberine organic acid salt comprises the following steps of: neutralizing solution of jamaicin and solution of organic acid into salt; crystallizing the salt; and filtering, leaching and drying the crystallized salt so as to obtain the berberine organic acid salt. The method for preparing the berberine organic acid salt inclusion compound comprises the following steps of: dissolving the inclusion base material; adding the berberine organic acid salt into the dissolved inclusion base material for dissolving and inclusion; cooling and standing reaction liquid to separate coprecipitate out; leaching the coprecipitate with acetone; and drying a filter cake so as to obtain the berberine organic acid salt inclusion compound. The berberine organic acid salt and the berberine organic acid salt inclusion compound provided by the invention have the advantages of high bioactivity, small dosage and high dissolubility. The preparation methods have the advantages of simple process, high product purity, easy operation control, simple equipment and easy realization of industrialized production.

The invention discloses an application of berberine as an herbicide. It is found through researches that berberine has an obvious weeding effect of clearing various weeds. In particular, berberine mixed with other herbicides such as glyphosate or acetochlor has a better weeding effect, wherein the mass ratio of berberine to other herbicide is preferably 1-2: 1. Berberine can be used to observablyinhibit the root growth or plant growth of weeds such as water lettuce, water hyacinth, duckweed, Arabidopsis thaliana, Bidens pilosa, Celosia argentea, Conyza bonariensis, Mikania micrantha and the like, and has a good weeding effect.

The invention discloses preparation methods of a sustained-release microcapsule and a sustained-release composite membrane for inhibiting the monilinia fructicola. The preparation method of the sustained-release microcapsule comprises the following steps: the chitosan and the berberine are weighed, the mass ratio between the chitosan and the berberine is 9-11:0.22-0.28, the acetate solution is added, then the chitosan and the berberine are sufficiently swelled to obtain berberine-chitosan solution after stirring for dissolving, standing and air bubble removal, and the berberine-chitosan solution is added in the soybean oil containing span 80, stirred at the constant temperature of 40-50 DEG C and then emulsified for 28-32 min to form a W/O system; the glutaraldehyde solution is added for stirring for 2.5-3.5 hours, and the centrifuging is carried out so that the microcapsule is fully settled; and the preparation liquid on the upper layer is obliquely taken, the obtained microcapsule is washed with petroleum ether for 3-5 times and then dried for 23-25 hours under the vacuum at the temperature of 48-52 DEG C. The invention also provides the preparation method for the sustained-release composite membrane for inhibiting the monilinia fructicola. Both the microcapsule and the composite membrane have the sustained-release effects and have no toxic side effect to the environment and the plants since the berberine is a native compound.

The invention relates to a preparation method of berberine hydrochloride which is a broad spectrum antibiotic. The method takes 2, 3-dimethoxy benzyl alcohol and homopiperony lamine as raw materials to prepare the berberine hydrochloride by six steps of reaction, namely, alkylation, chloromethylation, cyanidation, alcoholysis, condensation and cyclization. The synthetic technology has easily available materials, high yield but low cost, thus being suitable for industrial production.

The present invention provides tetrahydro protoberberine compounds as shown and their pharmaceutically acceptable inorganic or organic salts, crystallized hydrates, solvates and medicinal compositions. The present invention also provides their preparation process and application in preparing medicine for treating neurological diseases, especially dopamine acceptor related neurological diseases.

The invention relates to a dyeing method, which belongs to the technical field of dyeing and finishing. The method comprises the following steps that: 1) using cellulose use reaction type ultraviolet absorbers with anion radicals for carrying out modification treatment on cellulose type fabrics; and 2) using berberine for dyeing the modified fabrics. The invention adopts the cellulose use reaction type ultraviolet absorbers as modification agents, and the cellulose use reaction type ultraviolet absorbers and cellulose fiber take covalent crosslink reaction under the alkaline condition, so negative charges are introduced on the cellulose, the combination capability of the cellulose with cation natural dyestuff can be improved, the ultraviolet resistance capability of the cellulose type fabrics and the dyeing rate of the cation natural dyestuff can be improved at the same time through one-step modification, and the invention lays the foundation for the cellulose dyeing by the cation dyestuff. The berberine is selected for dyeing the cellulose type fiber such as cotton, hemp and the like, the invention has the advantages of green effect, health and no pollution, and the manufactured products have uniform color, and have good washing resistance firmness and friction resistance firmness.

The present invention relates to a class of chemically named long chain alkyl berberine salt derivatives (hydrochloride or Bromate or iodate or hydrofluoric acid salt), and the molecular structural formula is stated above, wherein, X is equal to F-, Cl-, Br-, I-, SO42-, NO3-, PO43-, citric acid radical, acetic acid radical or lactic acid radical. R1, R2, R3, R4, R5 see table above. The class of the substances is provided with obvious hypoglycemic and hypolipidemic activities which are significantly higher than that of berberine salt, so that the invention is a very promising new compound with hypoglycemic and hypolipidemic medicinal values.

The invention relates to a method for observing microscopic structures inside plant roots, which is capable of effectively solving the problem of utilizing a microscope to clearly observe the structures inside the plant roots. The method comprises the steps of digging out the plant roots, washing, shearing the plant roots into small sections, fixing the plant roots by methanol, and then embedding by a sepharose solution, cooling, condensing, trimming into small blocks, after freehand section, placing the small blocks into distilled water in a container, performing lactic acid clearing, covering, dyeing via berberine or fluorescein, bleaching by the water, performing poststaining via toluidine blue O or sarranine O, bleaching by the water, performing water seal, observing and photographing via an inverted fluorescence microscope, and obtaining a clear image. The method can be used for observing the microscopic structures inside the plant roots, thereby being effectively used for the research on classification, auxanology, ecology and physiology of medical plants. The method disclosed by the invention has the advantages of simple method, easiness in operation, low cost, low working capacity, high success rate, and good effect, thereby being capable of being used for the research on morphological anatomy of the roots. The method is simpler and more effective for the thinner root sections of the plants.

The invention relates to the technical field of pesticides and discloses a plant and animal-derived green environment-friendly pesticide and a preparation method thereof. The green environment-friendly pesticide is composed of wild plants, edible crops and animal bile, wherein the wild plants comprise Datura stramonium, castor seed and herba hydrocotylis wilfordi, the edible crops comprise king capsicum, garlic, Sichuan pepper and berberine, and the animal bile is fish bile, chicken bile or pig bile. The preparation method comprises the following steps: washing, crushing and squeezing the wild plants, carrying out chemical examination and extraction of alkaloid and screening out moisture impurities; washing and juicing or soaking the edible crops; washing an animal gallbladder and broking the animal gallbladder to obtain bile; and carrying out mixing and uniform stirring to obtain the pesticide. The pesticide prepared in the invention has bactericidal and anti-decay effects and the advantages of reasonable preparation, a cheap price, convenience in usage, capacity of being both sprayed and poured, no residual poison, no pollution, greenness and environment-friendliness and is applicable to poisoning of a variety of insects on a variety of plants like wheat, corn, cotton, fruit trees, vegetable, fruit and flowers and trees.

The invention provides a new application of berberine in the treatment of metabolic syndrome. Large-sample polycentric and randomized double-blind prospective experiments reveal the effect of berberine on metabolism of glucose and lipid and clarify the interrelation and common changes of the metabolism of glucose and lipid before and after berberine treatment. The berberine is used as a broad spectrum antibiotic and clinical drug with high efficiency and low toxicity for a long time and can be taken chronically without obvious side effect. Results of researches indicate that the berberine can help sufferers of type II diabetes mellitus combined with blood lipid abnormality regulate disorder of saccharometabolism and lipid metabolism, lower insulin resistance, avoid central obesity and elevation of blood pressure, thereby showing the positive effect of the berberine on the treatment of metabolic syndrome. The invention provides the new clinical application of berberine in the treatment of metabolic syndrome for human for the first time, which establishes the importance of the new clinical application of traditional Chinese medicine in the treatment of metabolic syndrome and provides a new basis as well, thereby helping to promote the traditional medicine of China.

The invention provides various novel compositions of berberine in combination with pharmacologically active organic acids, and related methods of their use in treating various diseases or disorders. The invention further provides various novel compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders. The compounds and pharmaceutical compositions of the invention can be utilized to treat various diseases or disorders, such as diabetes, diabetic complications, dyslipidemia, hyperlipidemia, obesity, metabolic syndromes, pre-diabetes, atherosclerosis, heart diseases, neurodegenerative diseases, sarcopenia, muscle atrophy, inflammation, cancer and liver diseases and conditions such as fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver diseases or graft-versus-host disease of the liver. The compounds of this invention are also useful in improving liver functions in chronic viral associated liver diseases and alcohol-related liver diseases.

This invention relates to compositions and methods of combining berberine, artemisinin and loperamide or their derivatives in a therapeutic product for mammals suffering from malaria, diarrhea, travelers' diarrhea, dysentery, dengue fever, parasites, cholera and viruses by administration of a therapeutically effective amount of the composition.