150 results about "Berberine" patented technology

The invention discloses a nano-drug material based on self-assembly of berberine and caffeic acid and a preparation method of the nano-drug material. The preparation method comprises the following steps: respectively dissolving berberine and caffeic acid in an organic solvent to prepare a berberine-organic solvent solution and a caffeic acid-organic solvent solution; adjusting the pH value of the caffeic acid-organic solvent solution to 7.0-7.5; adding the caffeic acid-organic solvent solution while stirring the berberine-organic solvent solution, uniformly mixing, adding the mixed solution into deionized water with the preheating temperature of 30-70 DEG C, and stirring at a constant temperature, so that the berberine and the caffeic acid are self-assembled to obtain a mixed solution; dialyzing the mixed solution to obtain a berberine and caffeic acid self-assembled solution; and performing vacuum freeze drying to obtain a target product. The nano-drug material disclosed by the invention is small in particle size, better in solubility and dissolution rate in different pH environments than berberine hydrochloride and caffeic acid eutectic, good in stability in an aqueous solution and environment-friendly in method.

The invention discloses a preparation process of berberine hydrochloride, and belongs to the technical field of berberine production. The invention relates to a berberine hydrochloride preparation process, which comprises: S1, mixing a ferric sulfate-aluminum sulfate composite salt, sodium chloride, zinc chloride and anhydrous formic acid, pre-activating, adding N-2, 3-dimethoxybenzyl homopiperony lamine hydrochloride, dropwise adding a glyoxal mixed solution, and carrying out a reflux reaction. And S2, cooling the reaction liquid until a solid is separated out, filtering, adding a filter cake and diatomite into purified water, stirring, adjusting alkali, heating, and continuously stirring for 0.5-1 hour. Cooling and filtering, and reserving filtrate; s3, adjusting the acidity of the filtrate, cooling and growing crystals; and filtering, rinsing a filter cake, and carrying out vacuum drying on the filter cake to obtain berberine hydrochloride. The berberine hydrochloride prepared by the method is high in yield and purity, and the preparation process is safe, short in flow and friendly to human bodies and environment.

The invention relates to the technical field of food packaging, in particular to a dual-antioxidant packaging film as well as a preparation method and application thereof. The dual antioxidant packaging film disclosed by the invention is prepared from the following components in parts by mass: 3.2 to 4 parts of starch, 0.8 to 1 part of glycerol, 0.8 to 1 part of polysaccharide, 0.02 to 0.16 part of berberine / anthocyanin self-assembled nanoparticles and 93.98 to 95.2 parts of water. The packaging film prepared by the invention is uniform in structure, has good mechanical properties and moisture and oxygen barrier properties, shows an intelligent slow release characteristic in a pH value change or oxidation environment, can realize controllable release of the tea tree essential oil, and significantly improves the antioxidant and antibacterial activity of the film. The material source is natural, renewable and biodegradable, and the environment-friendly fresh-keeping packaging material is suitable for fresh-keeping packaging of foods such as fruits, vegetables and meat products, and has good environment friendliness and industrial application prospects.

This invention relates to the field of plant component extraction technology, specifically to a method for efficiently extracting and purifying berberine. The method includes: (1) selecting dried stems of *Radermachera sinensis*, crushing and sieving them to obtain *Radermachera sinensis* powder; (2) weighing the *Radermachera sinensis* powder and mixing it with a 20-30% (w / w) ammonium sulfate solution, then adding a compound enzyme preparation for enzymatic hydrolysis, adding isopropanol to obtain a mixture, extracting the mixture using an ultrasonic-microwave synergistic extraction method, centrifuging the extracted mixture for 10-13 min at 3500-4000 rpm, removing the isopropanol layer by distillation to obtain a crude extract; (3) dissolving the crude extract in water and loading it onto a polar macroporous resin for multiple elutions to obtain berberine. Compared with the prior art, this invention uses an enzyme preparation followed by an aqueous two-phase solvent combined with ultrasonic-microwave extraction technology to promote the maximum release of berberine from *Radermachera sinensis* powder, thereby increasing the yield. Finally, a gradient elution with macroporous resin is used to achieve efficient extraction and purification of berberine.

The invention discloses a short-contact washing agent for treating scalp seborrheic dermatitis and bacterial folliculitis, and relates to the technical field of external preparations and scalp care, the short-contact washing agent comprises the following components by weight: an active component combination: 0.01-0.05 wt% of halcinonide; 0.5 to 1.0 wt% of piroctone ethanolamine; 0.1 to 0.3 wt% of total alkaloids of sophora flavescens; 0.05 to 0.1 wt% of berberine; standardized traditional Chinese medicine effective part extracts are compounded with modern active ingredients, and the problem that the quality difference between batches of traditional Chinese medicine lotion is large is solved. The combination of a plurality of active components aims to synergistically act on a plurality of targets such as anti-inflammation, antibiosis and oil control, so as to comprehensively improve the scalp condition. In addition, the specific semi-solid colloid dosage form improves the staying performance of the product on the scalp, and aims to improve the refreshing feeling after use while ensuring the cleaning effect. The lotion provides a hormone-containing and hormone-free double-version design, and provides choices for requirements of different severity degrees and different use stages.

This invention discloses a method for preparing a chitosan antibacterial film. First, berberine aqueous solution and tannic acid aqueous solution are prepared separately. Then, the berberine aqueous solution is added dropwise to the tannic acid aqueous solution to form a mixed solution. The mixed solution is stirred and heated to obtain a suspension. The suspension is freeze-dried to obtain berberine-tannic acid nanoparticles. Next, a chitosan acetic acid aqueous solution is mixed with the berberine-tannic acid nanoparticles, and a film is formed to obtain a chitosan antibacterial film loaded with berberine-tannic acid nanoparticles. The prepared chitosan antibacterial film has low water content and swelling degree, strong ultraviolet shielding ability, high transparency, and strong inhibitory activity against Staphylococcus aureus and Salmonella typhimurium, which can better meet the needs of food preservation.

The invention discloses application of berberine or berberine hydrochloride in preparation of drugs for resisting HPV infection related diseases. Preferably, the berberine is an extract of natural plants such as coptis chinensis, golden cypress, berberis poiretii schneid or Chinese mahonia. According to the application, the new application of the berberine or the hydrochloride thereof in the aspect of resisting the HPV virus is expanded, and the berberine or the hydrochloride thereof is used for preparing the preparation for resisting the HPV infection, so that diseases related to the HPV infection can be prevented or treated, and the virus is promoted to become negative. As a natural plant extract, berberine is high in safety and not easy to generate drug resistance, and has important clinical significance when being used for preparing Chinese patent medicine products for resisting HPV infection.

The invention provides an anti-cancer medicine and food homologous composition and a preparation method thereof. The composition is prepared from the following components in parts by weight: 5 to 10 parts of lipoic acid, 30 to 50 parts of nano curcumin, 2 to 7 parts of berberine, 50 to 100 parts of beta-glucan, 15 to 35 parts of polymethylacrylic acid, 15 to 25 parts of herba hedyotidis diffusae extract, 7 to 15 parts of scutellaria barbata baicalein, 25 to 55 parts of astragalus polysaccharide, 8 to 18 parts of coix seed ester and 10 to 15 parts of cordyceps cicadae. Through a space-time targeting synergistic release mechanism of a bionic nanocellulose skeleton and in combination with pH / enzyme double-response intelligent regulation and control, three-stage precise synergistic effects of oxidation resistance, apoptosis promotion and immune activation are realized, the limitation that a traditional medicinal and edible composition is poor in targeting property, low in synergistic efficiency and uncontrollable in toxicity is broken through, and the medicinal and edible composition has a broad application prospect. High-efficiency and low-toxicity tumor multi-channel synergistic intervention is achieved in a natural component system for the first time, and the actual effect of the whole medicinal and edible composition on cancer and swelling resistance is improved.

The present application belongs to the technical field of guava disease prevention and treatment, and particularly relates to a kind of fungicide composition for preventing and treating guava anthracnose.A kind of fungicide composition for preventing and treating guava anthracnose, its effective component is compounded by rock white menu lactone and berberine or flutriafol, wherein, the mass ratio of rock white menu lactone and berberine is 1-7:15-1;The mass ratio of rock white menu lactone and flutriafol is 1-20:20-1.Rock white menu lactone and berberine or flutriafol are compounded in the present application, and the synergistic coefficient SR for inhibiting the mycelium growth of guava anthracnose pathogenic bacteria is greater than 1.5, which shows synergistic effect.Compared with single component, the prevention and treatment effect on guava anthracnose can be improved.In addition, the fungicide composition of the present application is compounded by rock white menu lactone and berberine or flutriafol, compared with single component, the generation and development of pathogenic bacteria resistance can be delayed, and the service life of the pesticide can be prolonged.

The invention provides a pharmaceutical composition for treating prostatitis and a preparation method thereof. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 20 to 60 parts of palmatine, 20 to 60 parts of paeoniflorin, 10 to 30 parts of formononetin, 20 to 60 parts of astilbin and 10 to 40 parts of stigmasterol. In-vitro cell tests and in-vivo animal experiments prove that the pharmaceutical composition has the effect of relieving the chronic prostatitis reaction.

This invention belongs to the field of pharmaceutical technology, specifically relating to biomimetic nanomedicines for treating subcutaneous drug-resistant bacterial infections, their preparation methods, and applications. In this invention, dopamine hydrochloride is added during the synthesis of a metal-organic framework to prepare a dandelion-shaped carbon nanozyme precursor. This precursor is then carbonized to obtain a carbon nanozyme with targeting, photoresponsiveness, and peroxidase activity. Finally, berberine hydrochloride is loaded onto the carbon nanozyme to obtain the biomimetic nanomedicine. The biomimetic nanomedicine provided by this invention firstly possesses good biocompatibility; secondly, it has a unique dandelion-like morphology, which is beneficial for its targeting effect; and finally, it exhibits strong photoresponsiveness in the near-infrared region, enabling synergistic and efficient bactericidal action through the mechanisms of antibacterial drugs, photothermal therapy, and chemokinetics. It has significant application value in the preparation of drugs for treating subcutaneous drug-resistant bacterial infections.

The invention belongs to the technical field of microbial biopesticides, and particularly relates to a high-efficiency, low-toxicity and environment-friendly microbial pesticide, which is characterized in that effective components of the high-efficiency, low-toxicity and environment-friendly microbial pesticide are formed by compounding microbial active components and compounding factors; wherein the microbial active component is P.megatherium; the microbial active component is P.megatherium; the compound factor is physcion or berberine. The bacterium content of the microbial active component, namely, the preristeria megatherium, is 5.0 * 10 < 10 > cfu / g, and the preristeria megatherium has a relatively good inhibition effect on the growth of fungal pathogenic bacteria mycelia and has the potential of being developed into a microbial bactericide; when the compound is compounded with the existing biopesticide physcion or berberine, the compounded composition has a synergistic effect on the growth of fungal pathogenic bacteria hyphae of crops, and compared with the single use of the microbial active component, the compound composition can improve the prevention and treatment effect on diseases, is beneficial to reducing the application amount of the pesticide, and has a good application prospect. And the method is of great significance to development of compound microbial biopesticides.

This invention discloses a pharmaceutical composition containing the natural products osthol and berberine, exhibiting synergistic antibacterial and antifungal effects. The effectiveness of osthol in synergistically enhancing the antibacterial activity of berberine was demonstrated through checkerboard minimum inhibitory concentration (MIC) tests, antifungal activity experiments, and in vitro bacterial growth curves. This invention provides a novel application of the combined use of osthol and berberine in antibacterial and antifungal treatments. This composition belongs to the category of traditional Chinese medicine compound preparations, offering a new treatment strategy for the clinical treatment of bacterial and fungal infectious diseases.

The invention relates to the technical field of plant growth regulation, in particular to application of berberine based on ACAA targets in resisting plant viruses and promoting plant growth. The invention reveals that berberine plays a role by specifically targeting acetyl coenzyme A acyltransferase and up-regulating the expression of the acetyl coenzyme A acyltransferase for the first time. The clear compound-target-pathway mechanism overcomes the defect that the existing plant source product mechanism is unknown. As the target spot is clear, the application dosage can be accurately controlled, so that the stability and predictability of field antiviral and growth promoting effects are ensured, and a foundation is laid for large-scale agricultural application. An ACAA target is activated by berberine, and an antiviral defense mechanism and an energy metabolism growth pathway of a plant can be synchronously started, so that the plant growth is effectively promoted while virus diseases are prevented and treated. The disease resistance-growth negative correlation problem existing in agricultural production for a long time is solved, and the dual requirements of modern agriculture for precise prevention and control and yield increase and quality improvement are met.

Disclosed are a crystalline form of a high-stability nor-ursodeoxycholic berberine salt and a preparation method therefor, while relate to the field of pharmaceutical chemistry. The crystalline form has the following structural formula. In X-ray powder diffraction of the crystalline form, a 2θ diffraction angle has characteristic peaks at 3.54+ / -0.2 degrees, 7.13+ / -0.2 degrees, 13.14+ / -0.2 degrees, 15.95+ / -0.2 degrees, 16.40+ / -0.2 degrees, 18.64+ / -0.2 degrees, 24.90+ / -0.2 degrees, 25.76+ / -0.2 degrees and 26.30+ / -0.2 degrees. Compared with other crystalline forms of the nor-ursodeoxycholic berberine salt, the crystalline form has more excellent stability, and has a good application prospect in the preparation of high-quality solid chemical drugs.

This invention discloses a spray composition, its preparation method, an oral care device, and its application, belonging to the field of biomedical technology. The composition is a synergistic compound of a herbal enzyme solution prepared by a "cell wall breaking-enzymatic hydrolysis-fermentation" process and a lyophilized stem cell exosome powder. The herbal enzyme solution contains berberine ≥1.2 mg / mL and baicalin ≥1.0 mg / mL, exhibiting high anti-inflammatory (IL-1β inhibition rate ≥55%) and deodorizing (VSC decomposition rate ≥88%) effects. The lyophilized exosome powder is rich in VEGF (≥50 pg / mg protein) and TGF-β1 (≥30 pg / mg protein), promoting gingival repair. The stability and delivery challenges of exosomes are solved through "lyophilization and reconstitution + ultrasonic atomization," resulting in atomized particles of 1–10 μm (D50 = 1–5 μm). Experimental results show that the gingivitis redness and swelling subsides in ≥90% of cases, the gingival recession thickness increases by 0.4–0.6 mm in 8 weeks, fresh breath is maintained for 4–6 hours, and the healing cycle of oral ulcers is shortened by 40%–50%, achieving a synergistic effect of "immediate antibacterial and anti-inflammatory treatment + long-term tissue repair".

The invention discloses application of oxidized berberine and berberrubine in treatment of diabetic osteoporosis, and belongs to the technical field of biological medicine. Researches find that both oxidized berberine and berberrubine have the effect of treating diabetic osteoporosis, and can significantly improve the femur microstructure of a diabetic osteoporosis model animal, so that the femur microstructure recovers to a normal level; the blood glucose clearing capacity can be improved, the insulin resistance index is reduced, and the insulin signal channel function is recovered; the oxidative stress state of diabetic osteoporosis model animals can be relieved, the proinflammatory factor level is reduced, and the anti-inflammatory and anti-oxidation effects are achieved. The invention provides a new scheme and data support for the treatment of diabetic osteoporosis, has better curative effect, safety and economy than the prior art, and has important clinical transformation value.

This invention discloses the application of berberine-loaded herbal carbon dots in the preparation of drugs for treating ulcerative colitis. The BLCDs of this invention exert their therapeutic effect through a dual synergistic mechanism: directly scavenging reactive oxygen species through surface oxygen-containing functional groups, and simultaneously inhibiting the NLRP3 inflammatory pathway and downstream pro-inflammatory factors by promoting IL-10 expression. In a DSS-induced ulcerative colitis mouse model, BLCDs showed superior efficacy compared to the positive control drug 5-ASA and its single component, significantly improving intestinal inflammation, oxidative stress, and barrier dysfunction. Their therapeutic advantage stems from the intestinal retention effect conferred by their larger particle size, as well as their regulatory effects on intestinal flora and metabolites, particularly by inhibiting Klebsiella to reduce TMAO production, thereby activating the multi-cascade regulatory network of IL-10.

The invention discloses a traditional Chinese medicine capsule for treating diabetes and a preparation method thereof, and belongs to the technical field of medicine preparation. The capsule is composed of main materials and auxiliary materials. The main materials are composed of 23-27 g of radix astragali, 23-27 g of radix puerariae, 18-22 g of rhizoma polygonati, 18-22 g of Chinese yam, 13-17 g of radix scrophulariae, 13-17 g of radix rehmanniae praeparata, 13-17 g of radix salviae miltiorrhizae, 8-12 g of rhizoma coptidis, 8-12 g of silkworm excrement, 8-12 g of rhizoma polygoni cuspidati, 7-9 g of liquorice and 5-7 g of fructus momordicae. The auxiliary material consists of lactose, microcrystalline cellulose and superfine silica powder in a mass ratio of 10: 10: 1, and the total weight of the auxiliary material is 210g. Double-section countercurrent extraction and low-temperature belt type drying are adopted, the retention rate of effective components is increased, the content of berberine and the content of salvianolic acid B are increased by 18% and 22% respectively, in addition, particle size grading compatibility is adopted, quick release and gastrointestinal tolerance are both considered, artificial sweeteners or chemical hypoglycemic drugs are not additionally added to the finished product, and the finished product conforms to human body metabolic motility.

The invention relates to the technical field of antibacterial composition preparation, in particular to a gynecological antibacterial composition and a preparation method thereof, and the gynecological antibacterial composition comprises the following raw materials: modified radix sophorae flavescentis, angelica sinensis, modified cortex phellodendri, radix paeoniae rubra, ligusticum wallichii, bombyx batryticatus, salvia miltiorrhiza, safflower carthamus, fructus cnidii, gallnut, calamine, pomegranate rind, catechu, rhizoma atractylodis, dragon's blood, fructus kochiae, borneol, alum, dried alum, purpurea sal ammoniac, magnesium stearate and starch. According to the invention, after the modified radix sophorae flavescentis is subjected to ethanol ultrasonic extraction, purification and micronization treatment, the dissolution rate and purity of effective components such as sophocarpidine are improved, the cell membrane structure of gram-negative bacteria such as escherichia coli can be quickly destroyed, and efficient bacteriostasis is realized; the modified cortex phellodendri is subjected to alkali dissolution extraction, acid precipitation purification and refined drying, berberine hydrochloride is efficiently enriched, the purity is improved, and the berberine hydrochloride can kill fungi such as candida albicans more accurately and strongly; and through high-temperature calcination and acetic acid activation, the calamine and the catechu are tightly combined at a microscopic level, so that the inherent convergence, granulation promoting and antibacterial effects of the calamine and the catechu are enhanced.

The application relates to the technical field of medicine research, in particular to a 5-azacyclic structure substituted berberine jatamansi alkaloid derivative with antibacterial and insecticidal activity and a preparation method and application thereof. The specific structure is as follows: the 5-azacyclic structure substituted berberine jatamansi alkaloid derivative has good insecticidal, bacteriostatic and antibacterial activities, especially the bacteriostatic activity, and the application of the berberine jatamansi alkaloid derivative in the field of agricultural chemicals and medicines is enriched.

This invention discloses the application of plant extracts in the preparation of drugs that inhibit canine parvovirus, belonging to the field of biomedical technology. The plant extract is at least one selected from phlorizin, neomethylhesperidin-dihydrochalcone, tribulus terrestris saponin, stevia glycoside, soy isoflavones, berberine hydrochloride, diosgenin, and silymarin. Through in-depth research on various plant extracts, this invention has found that phlorizin, neomethylhesperidin-dihydrochalcone, tribulus terrestris saponin, stevia glycoside, soy isoflavones, berberine hydrochloride, diosgenin, and silymarin all exhibit significant inhibitory effects on canine parvovirus, with soy isoflavones showing particularly outstanding effects. This research provides a novel natural drug option for the prevention and treatment of canine parvovirus. This invention not only expands the application scope of natural plant extracts in the veterinary medicine field but also provides important technical support for the development of novel, highly effective, safe, and side-effect-free drug formulations for the prevention and treatment of canine parvovirus.

The invention discloses an indwelling scalp care pomade composition and a preparation method thereof, and relates to the technical field of daily chemical products, the indwelling scalp care pomade composition comprises the following components by mass: 7-26% of a wax / fat phase, and 0.5-3% of an emulsification system; 0.5% to 4% of a touch powder; 0.05% to 0.8% of a cationic conditioner; the compound comprises at least three mass markers selected from the group consisting of cnidium lactone, glycyrrhizic acid or a mono-ammonium salt thereof, total flavonoids of rhizoma smilacis glabrae, berberine, baicalin, salvianolic acid and indirubin, and through the cooperation of the added herbal components and the taste control module in the process, the stability of the active components is maintained, and the taste of the active components is improved. The overall smell characteristic of the product is effectively controlled, and finally the matte pomade product with good performance in the aspects of shaping durability, visual attractiveness, scalp friendliness and use comfort is obtained.

The application discloses a co-crystal of berberine hydrochloride and m-hydroxybenzoic acid and a preparation method thereof, wherein the co-crystal of berberine hydrochloride and m-hydroxybenzoic acid is formed by the berberine hydrochloride and the m-hydroxybenzoic acid in a molar ratio of 1:0.5-1.5, the co-crystal is a triclinic system, a P-1 space group, and the cell parameters are as follows: alpha / °=102.49+ / -0.2, beta / °=100.51+ / -0.2, gamma / °=117.81+ / -0.2, and Z=2. The co-crystal formed by the berberine hydrochloride and the m-hydroxybenzoic acid can significantly improve the dissolution rate and the dissolution speed of the berberine hydrochloride, the bioavailability of the berberine hydrochloride is significantly increased, the co-crystal has a good treatment effect, and is suitable for clinical application.

This invention proposes a method for rapid determination of the content of Phellodendron amurense charcoal slices processed at different temperatures using near-infrared spectroscopy. Near-infrared spectroscopy is used to collect spectral information of Phellodendron amurense charcoal slices processed at different temperatures. Background interference is eliminated through preprocessing methods such as baseline correction, standard normal variable transformation, multivariate scattering correction, and first derivative. Combined with competitive adaptive reweighted sampling, CARS combined with iterative retention of information variables, and iterative combination optimization, a partial least squares regression quantitative prediction model is established. This model achieves accurate prediction of the content of five key components: 5-O-FQA, 3-O-FQA, berberine, berberine, and berberine, with prediction correlation coefficients all exceeding 0.90. This invention combines spectral information with chemometric methods to establish a digital content prediction model based on near-infrared spectroscopy for online monitoring of the Phellodendron amurense charcoal slice processing process. It has the advantages of objectivity, speed, non-destructive nature, and reliability, effectively solving the technical problem of lack of objectivity in existing technologies based on human judgment.

The invention discloses a compound composition based on a Gegen Qinlian decoction, and belongs to the technical field of medicines. The active ingredients of the compound composition comprise puerarin, baicalin, berberine, glycyrrhizic acid and paeoniflorin, and the compound composition comprises pharmaceutically acceptable auxiliary materials. The daily dose of the compound composition is prepared from the following components in parts by mass: 50 to 300 parts of puerarin, 50 to 800 parts of baicalin, 50 to 800 parts of berberine, 25 to 300 parts of glycyrrhizic acid and 30 to 150 parts of paeoniflorin. The compound composition is composed of five clear active components, and through accurate control and standardized quality control of the active components, the stability of the product quality and the reliability of the curative effect are fundamentally ensured. Network pharmacological analysis and animal experiment results show that the composition has antipyretic, anti-inflammatory and analgesic effects, is matched with the traditional Chinese medicine effects of relieving muscles and relieving exterior syndrome, clearing away heat and toxic materials, and promoting diuresis and stopping dysentery, and is suitable for treating stomachache, headache and body pain.

The disclosure provides omega-7 fatty acid berberine salts and uses thereof.

To provide an oral composition that has a high astringent effect and high storage stability of berberine. [Solution] An oral composition comprising (A) component: berberine, (B) component: hinokitiol, and (C) component: isopropylmethylphenols, wherein the content of component (B) is 0.001 to 0.5% by mass relative to the total mass of the oral composition, and the ratio of the mass of component (C) to the mass of component (B), expressed as component (C) / component (B), is 0.01 to 10.

The application discloses a preparation method and application of a nano self-assembly composition of arbutin-berberine, and comprises the following steps: dissolving berberine in methanol at 38-42 DEG C, adding an arbutin super-pure water solution at 38-42 DEG C, and stirring and keeping warm for 0.8-1.2 h to obtain a self-assembly solution; then, the self-assembly solution is subjected to vacuum rotary evaporation and freeze drying in sequence, and the nano self-assembly composition of arbutin-berberine is obtained. The traditional Chinese medicine nano self-assembly system based on arbutin and berberine is successfully constructed, the nanoparticles are spontaneously formed under mild conditions through intermolecular non-covalent interaction, the preparation process is simple and convenient, the conditions are mild, the damage of high temperature and other harsh conditions to active ingredients is effectively avoided, and the process adaptability is high.