419 results about "Curcumin" patented technology

The invention relates to the technical field of food fresh-keeping materials, in particular to a chitosan-curcumin nano-composite fresh-keeping agent and a preparation method thereof.The chitosan-curcumin nano-composite fresh-keeping agent comprises nano-particles of a chitosan-sodium alginate-oxidized sodium alginate interpenetrating network structure, according to the nanoparticles, protonated amino groups of chitosan and carboxyl groups of sodium alginate form a polyelectrolyte compound core, aldehyde groups of oxidized sodium alginate and amino groups of chitosan are subjected to a Schiff base reaction to form a chemical cross-linked network, and zinc ions, amino groups of chitosan, carboxyl groups of sodium alginate and carboxyl groups of oxidized sodium alginate form coordination cross-linking; curcumin and epigallocatechin gallate form a compound through a hydrogen bond and a hydrophobic effect, the compound is embedded in an interpenetrating network structure, beta-diketone groups of curcumin and zinc ions form chelating coordination, a chitosan-sodium alginate-oxidized sodium alginate ternary interpenetrating network is constructed, and the chitosan-sodium alginate-oxidized sodium alginate ternary interpenetrating network structure is formed. The stability is improved by utilizing the synergistic effect of triple mechanisms of electrostatic interaction, Schiff base chemical bonds and zinc ion coordination.

The invention provides a composite hydrogel for infectious bone defect repair and a preparation method thereof, and belongs to the technical field of bone defect repair, the composite hydrogel comprises a three-dimensional porous network structure hydrogel and a bioactive unit, and the bioactive unit is loaded in the three-dimensional porous network structure hydrogel; the hydrogel with the three-dimensional porous network structure is prepared from photo-crosslinked methacrylated silk fibroin and nano-hydroxyapatite; the bioactive unit comprises a strontium metal organic framework loaded with curcumin. According to the invention, the photo-crosslinked methacrylated silk fibroin provides excellent biocompatibility; as an ion / drug dual carrier, the strontium metal organic framework can continuously release strontium ions and bidirectionally regulate bone metabolism (promoting osteogenesis and inhibiting osteoclast), and the porous structure of the strontium metal organic framework can efficiently load a hydrophobic drug curcumin (Cur). Curcumin has strong antibacterial and anti-inflammatory functions; the nano-hydroxyapatite can obviously enhance the mechanical strength of the hydrogel.

The invention discloses a targeted slow-release curcumin compound with an auxiliary liver protection function and a preparation method thereof.The preparation method comprises the steps that whey protein isolate is heated under the acidic condition to prepare whey protein isolate fibers, and then the whey protein isolate fibers are compounded with kappa-carrageenan; adjusting the mixed system to be alkaline by adopting a pH migration method, adding a curcumin alkaline solution, fully dissolving the curcumin alkaline solution, and combining the curcumin alkaline solution with the whey protein isolate fiber-kappa-carrageenan composite system; and adjusting the pH value of the system back to be neutral to obtain the high-load amorphous curcumin solution and the solid preparation. The whey fiber and the kappa-carrageenan are self-assembled in the pH circulation process to form a composite carrier, curcumin is converted into an amorphous state from a crystalline state, the solubility of curcumin is remarkably improved, the loading capacity is greatly improved to 70% at most, the heat stability, oxidation resistance and biological accessibility of curcumin are improved, targeted slow release of curcumin can be achieved, and the curcumin-targeted slow release preparation has a good application prospect. The positioning release performance of the curcumin in the intestinal tract part is improved, and the application form of the curcumin in liver protection function products is expanded.

The invention discloses a preparation method of a liver protection medicine composition containing dihydromyricetin, and relates to the technical field of medicine preparation.According to the method, dihydromyricetin, puerarin, pueraria flower extract, corn oligopeptide, pyrroloquinoline quinone disodium salt, curcumin and ganoderan are used as raw materials; dihydromyricetin and puerarin are stirred, homogenized and dried in a mixed solvent to prepare the liver protection medicine composition, wherein the mass ratio of dihydromyricetin to puerarin is 1: (0.5-2). A multi-target liver protection system is constructed through cooperation of multiple components, the problems that a traditional liver protection medicine is poor in component solubility, easy to degrade in activity and weak in synergistic effect are solved, the bioavailability and stability of the product are improved, the process is simple and controllable, the preparation method is suitable for industrial production and can be prepared into oral preparations such as tablets and oral liquid, and the preparation method is suitable for industrial production. The composition is suitable for protection of alcoholic and chemical liver injury.

The invention provides a feed premix for improving chicken quality. The fresh-keeping agent is prepared from the following components in percentage by weight: 5%-15% of a flavor enhancing component, 10%-25% of a tenderness improving component, 3%-10% of an antioxidant fresh-keeping component, 2%-3% of a function enhancing component and the balance of a carrier and a diluent, the function strengthening component is prepared from beta-alanine embedded citronella essential oil and konjac glucomannan zymolyte; the flavor enhancing component comprises a rosemary extract, a yeast culture and curcumin in a mass ratio of (2-4): (1-3): 1; the tenderness improving component comprises conjugated linoleic acid, L-carnitine modified by glutamine transaminase and betaine in a mass ratio of (3-5): (2-4): 1; the antioxidant fresh-keeping component is vitamin E and tea polyphenol in a mass ratio of (1-2): 1. Through multi-component synergism and functional targeting optimization, a three-dimensional quality improvement system with enhanced flavor, improved tenderness, oxidation resistance and fresh keeping is constructed, so that the chicken quality is comprehensively upgraded.

The present invention relates to a microneedle-based transdermal delivery patch fabricated from a hydrogel composed of polyvinyl alcohol (PVA), arginine-modified chitosan, and a crosslinker. The arginine-modified chitosan is prepared by reacting a chitosan solution with an arginine solution preactivated with N-hydroxy succinimide and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide at a specific pH. The hydrogel's formulation further comprises a PVA concentration ranging from 10% to 12% (w / v). arginine-modified chitosan and PVA solution are mixed in a 1:2 ratio by volume and are crosslinked using trimethyl orthoformate (TMOF). The patch is further loaded with curcumin, with a concentration of 120μg per patch, demonstrating a 70% release over 48 hours in a controlled manner. This invention represents the first application of PVA crosslinked arginine-modified chitosan hydrogel loaded with curcumin specifically for animal wound healing, providing enhanced wound healing and antibacterial efficacy.

The invention relates to the technical field of biology, in particular to saffron petal polysaccharide loaded curcumin gel beads as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing stigma croci petals and water, heating in a water bath, refluxing, filtering, extracting, carrying out rotary evaporation and concentration, taking supernate, adding absolute ethyl alcohol, standing, precipitating, carrying out centrifugal suction filtration, collecting polysaccharide, adding water for redissolving, carrying out rotary evaporation to remove ethyl alcohol, and freeze-drying for later use; uniformly mixing the freeze-dried saffron petal polysaccharide solution with a curcumin solution to obtain a petal polysaccharide-curcumin solution; sequentially adding sodium alginate and a calcium lactate solution into the petal polysaccharide-curcumin, uniformly mixing, and cross-linking to obtain the negative petal polysaccharide-curcumin composite gel beads. The curcumin is loaded by the sodium alginate, calcium lactate and crocus sativus petal polysaccharide composite material, so that the hardness and the structural stability of the gel beads are enhanced, the encapsulation efficiency of the curcumin is improved, targeted slow release is favorably realized, and a practical scheme is provided for efficient delivery of natural active ingredients.

Methods of making bioactive compound-loaded nanoparticles are provided. The methods harness naturally-occurring biopolymers to produce nanoparticles from raw plant materials. Methods include contacting plant-derived materials with alkaline solution with agitation to deprotonate the bioactive materials and biopolymers to form nanoparticles. In some forms, the methods contact the nanoparticle with an acid to re-protonate the components and more stable nanoparticles. The bioactive compounds can be extracted from raw plants and / or plant parts, including turmeric, ginger, clove, thyme, pepper, and rosemary. The bioactive compounds include curcumin, gingerols, shogaols, eugenol, thymol, carvacrol, capsaicin, and rosmarinic acid. Compositions and formulations containing bioactive-compound loaded nanoparticles are also provided.

The invention discloses a functional lipid compound for nano-liposome wrapping and a preparation method, and relates to the technical field of functional lipid compounds, the functional lipid compound comprises (a) a polyphenol-lipid covalent conjugate which is composed of a polyphenol active unit selected from curcumin, dihydroquercetin or derivatives thereof, and (b) a lipid covalent conjugate which is composed of a polyphenols active unit selected from curcumin, dihydroquercetin or derivatives thereof and a polyphenols active unit selected from curcumin, dihydroquercetin or derivatives thereof; the conjugate is covalently linked to a phosphatidyl ethanolamine or cholesterol skeleton through a cleavable linking group, and the conjugate can be integrated into a nano-liposome membrane and has the functions of structural support and biological activity; (b) a microenvironment-responsive functional phospholipid, which is a phospholipid derivative having a functional group responsive to an inflammatory microenvironment specific stimulus modified on a hydrophilic head group or a hydrophobic chain of a phospholipid molecule, the specific stimulus being selected from local pH < = 6.5, reactive oxygen species (ROS) concentration > = 10 [mu] M or matrix metalloproteinase MMP-2 / 9 overexpression; and (c) a bionic exosome membrane lipid component, wherein the bionic exosome membrane lipid component comprises sphingosine-based glycolipid or sulfated cholesterol separated from the plant-derived exosome.

The invention provides curcumin composite particles for improving alcohol-related liver diseases and a preparation method of the curcumin composite particles, and belongs to the technical field of nutritional active ingredient delivery systems. According to the preparation method, zein is taken as a core carrier, curcumin encapsulation is realized through an anti-solvent precipitation method, a compact gel middle layer is constructed by further adopting the protection performance of carrageenan and combining calcium ion mediated ionic crosslinking, and then the outer layer is coated with galactosylated chitosan with liver targeting property through electrostatic adsorption, so that the curcumin-containing hydrogel is prepared. And the curcumin-zein-carrageenan-galactosylated chitosan composite particle with a core-shell-shell structure is innovatively constructed. Compared with free curcumin, the composite particle has obviously improved light and heat stability, realizes controlled release of curcumin in a gastrointestinal tract environment, exerts an effect of obviously improving the alcohol-related liver disease, and has a good application prospect in the aspect of development of functional products for preventing and treating the alcohol-related liver disease.

A curcumin nanococrystal composition including curcumin, a coformer, and a stabilizer. The coformer may include at least one of 3,5-dinitrobenzoicacid, gentisic acid, phloroglucinol, 4,4-bipyridine, tartaric acid, citric acid, and gallic acid. The curcumin nanococrystal composition has a particle size less than 10 nm, and the curcumin has a water-solubility between 5 mg / ml and 20 mg / ml.

The invention provides a compound preparation containing curcumin nano-particles as well as a preparation method and application of the compound preparation. Curcumin is wrapped by alcohol-soluble protein to form nano-particles, and the nano-particles are used as a Pickering milk solid emulsifier for emulsifying and dispersing vitamin D and olive oil into an oil phase to form a stable droplet structure; furthermore, polysaccharide with enteric characteristics is used as a water-phase carrier material, and the emulsion is encapsulated in the pellet by using a hole sharpening-solidification method, so that the solidification of the liquid medicine (the emulsion) is realized; the three natural components, namely the curcumin, the vitamin D and the olive oil, are ingeniously integrated into a whole; the targeting property of the medicine at the colon part is improved; meanwhile, the destructive effect of the gastrointestinal tract environment on the medicine carrying nanoparticles is reduced.

The invention discloses a coffee-flavor plant extract and a preparation method thereof, and the coffee-flavor plant extract is refined by using lophatherum gracile, Chinese olive, folium cortex eucommiae, dendrobium officinale, astragalus membranaceus, codonopsis pilosula, dandelion and liquorice as composite plant raw materials through multi-strain synergistic fermentation and oak barrel aging and curing technologies. The dissolution rate and bioavailability of various bioactive components such as chlorogenic acid, ginsenoside, curcumin and dendrobium polysaccharides are effectively improved through multi-strain synergistic fermentation. The oak barrel ageing endows the product with unique baking, nut and vanilla flavors, the taste is mellow, and the flavor characteristic of coffee is effectively simulated. The plant extract prepared by the invention is rich in various functional components, and can assist in improving the memory ability. Meanwhile, a healthy, caffeine-free and rich-flavor herbaceous plant beverage is provided for consumers, a new solution is provided for product development of plant extracts, and huge market potential and economic value are achieved.

This invention discloses a multi-target synergistic anti-liver cancer medical food granule and its preparation method. The granule uses medicinal and edible homologous foods and novel resource foods as raw materials, and is composed of curcumin extract, esterified fat-soluble EGCG, Moringa leaf powder, yeast β-glucan, Astragalus extract, Schisandra extract, Salvia miltiorrhiza extract, Poria cocos powder, resistant dextrin, and erythritol in a specific ratio to construct a three-dimensional synergistic system of "direct killing-immune regulation-liver protection," which can induce ferroptosis in liver cancer cells, inhibit protective autophagy, activate the body's immunity, and protect liver cells. This invention employs directional extraction, multi-layer coating, and high-pressure fusion granulation technology. Nanoparticle liposome encapsulation, esterification modification, and pH-responsive enteric coating improve the stability and bioavailability of the components, solving the problems of poor water solubility, low absorption, and easy degradation of natural active ingredients. The granule has clear efficacy, high safety, and stable process, and can be used as a medical food for adjuvant therapy and nutritional support during the recovery period of liver cancer.

The invention discloses a curcumin nanocrystal preparation as well as a preparation method and application thereof. The invention relates to a curcumin nanocrystal composition which is prepared by drying and curing a curcumin nanocrystal suspension to a blank pellet core, the curcumin nanocrystal suspension contains 20-35% of curcumin nanocrystals, 1-10% of a three-dimensional protective agent and 1-10% of a charge protective agent, and the average particle size of the curcumin nanocrystals is 200-320 nm. The curcumin nanocrystal composition prepared by the invention can effectively prevent and treat heat stroke and complications thereof, remarkably improve heat tolerance, prolong survival time, reduce the level of inflammatory factors in blood, protect intestinal epithelial cells and intestinal barrier functions, reduce damage caused by heat stroke, prevent and treat body and organ damage caused by heat stroke, and improve the curative effect of the curcumin nanocrystal composition. The preparation has the advantages of being high in drug loading capacity, good in stability, high in bioavailability, safe, effective, convenient to carry and the like.

The present application relates to a kind of nanodroplet system based on interface crosslinking curcumin and its preparation method, by the crosslinking complexation between gallic acid ester, metal ion, curcumin to construct nanodroplet system.Gallic acid ester is polyphenol compound, contains a large number of phenolic hydroxyl in structure, has strong chelating metal ability, can be complexed with most of trivalent metal ions and divalent excessive metal ions, called metal phenolic network;Metal ions such as copper, iron and other metal ions form complex by electrostatic interaction with the beta diketone group in the structure of curcumin.Therefore, the nanodroplet system constructed by the present application can maintain the chemical stability and light stability of curcumin, and has wide prospect for improving the current food field curcumin low solubility, poor stability and other problems.

The application belongs to the field of biomedical materials and biomedical engineering technology, and discloses a pH-responsive curcumin sustained-release microsphere hydrogel, a preparation method and application thereof in spinal cord injury repair materials. The preparation method is as follows: short fibers are prepared by pretreating and grinding discarded eggshell membranes; after sodium alginate is dissolved, the sodium alginate is blended with the eggshell membrane short fibers, curcumin is added, and stirring is uniformly performed to form a mixed solution; the mixed solution is injected into a calcium chloride solution by using a drip crosslinking method to form, and an eggshell membrane and sodium alginate curcumin microsphere hydrogel is obtained. The hydrogel has excellent water content, swelling performance, biocompatibility, blood compatibility and drug sustained-release function, and can be applied to spinal cord injury repair.

This invention discloses a Zn-based framework material, Bi-Cur@Zn-MOF, its preparation method, and its applications in antibacterial and antioxidant properties, belonging to the field of functional materials and biomedical technology. The method specifically involves: dissolving zinc salt in water to obtain a zinc salt solution; dissolving curcumin and biotin together in water to obtain a mixed solution, and adjusting the pH of the mixed solution; mixing and stirring the zinc salt solution and the mixed solution evenly to obtain a precursor solution; subjecting the precursor solution to a hydrothermal reaction; after the reaction, performing solid-liquid separation and collecting the solid; washing and vacuum drying the solid to obtain the Zn-based framework material, Bi-Cur@Zn-MOF. The preparation method of this invention is green and simple, requiring no toxic reagents, and is suitable for large-scale preparation. The Bi-Cur@Zn-MOF prepared by this invention possesses both antibacterial and antioxidant functions, exhibits structural stability and good biocompatibility, and can be used to prepare medical dressings, food packaging materials, skin care products, wound repair, and antioxidant and antibacterial coatings, etc.

The invention discloses a preparation method of curcumin, and belongs to the technical field of natural product extraction. The method comprises the following steps: firstly, adopting a modified deep-eutectic solvent into which propyl gallate is introduced as an extraction medium, and realizing high-selectivity extraction of curcumin through a special molecular structure of the modified deep-eutectic solvent; then the ultrasonic-microwave coupling technology is combined, so that the extraction efficiency is remarkably improved; finally, the modified molecularly imprinted polymer with magnetism is used for precise purification, the material has the specific recognition capacity and the rapid magnetic separation characteristic, polyethylene glycol is introduced to serve as a pore-foaming agent, and more active sites are provided for adsorption of curcumin molecules. According to the method disclosed by the invention, through collaborative innovation of all links, the whole process optimization from extraction to purification is realized, the product purity and the extraction efficiency are remarkably improved, the energy consumption and the solvent pollution are greatly reduced, and a reliable solution is provided for industrial production of the high-quality curcumin.

This invention belongs to the field of genetic engineering technology, specifically relating to an engineered bacterium that efficiently synthesizes curcumin using ferulic acid as a precursor, its construction method, and its application. This invention enhances ferulic acid uptake and precursor supply capabilities from the source by knocking out the fdc and mcrC genes and overexpressing the tnaT and accD genes. Furthermore, it achieves high-level stable expression of exogenous key enzyme genes DCS and CURS through codon optimization. Combined with the synergistic effect of a two-stage fermentation regulation process, a stepwise increase in ferulic acid conversion rate is achieved. In a fermentation system with an initial ferulic acid concentration of 5 g / L, the conversion rate of the recombinant strain of this invention increased from 28.6% to 55.2% compared to the unoptimized strain, and further reached 80.2% after fermentation process optimization. Simultaneously, it effectively inhibits the formation of the byproduct 4-vinylguaiacol, significantly improving the utilization rate of ferulic acid and reducing the raw material cost of curcumin biosynthesis.

The invention belongs to the technical field of biological medicines, and particularly discloses an anti-fatigue and joint protection composition for sports people, which comprises the following components in percentage by mass: 10-25% of citrus bioflavonoid, 5-15% of taurine, 15-30% of eggshell membrane powder, 2-8% of curcumin compound, 1-5% of citric acid and the balance of maltooligosaccharide. Under the synergistic interaction of the citrus bioflavonoid, the taurine, the eggshell membrane powder and the curcumin compound, the composition with excellent anti-fatigue and joint protection effects is obtained.

This invention belongs to the field of new materials and relates to a multi-compartment polysaccharide colloidal material and its preparation method driven by both aqueous phase temperature and pH. The method uses polysaccharides with an upper critical eutectic temperature or a lower critical eutectic temperature as wall materials. The non-covalent bonds, such as hydrogen bonds, formed between the polysaccharide and curcumin at the response interface serve as stabilizing forces. Initiated by both temperature and pH, and under continuous flow conditions, a multi-stage reaction pathway is employed to load weakly acidic, weakly basic, or amphoteric dissociative compounds into different compartments. Compared to traditional emulsion template methods, nanoprecipitation methods, or physical encapsulation methods, this invention does not require the introduction of surfactants or particulate templates, nor does it require organic solvents. The operation process is simple and controllable, possessing good structural applicability and potential for large-scale continuous preparation.

The invention discloses a lactobacillus delbrueckii subsp. Bulgaricus CCFM1520 for transforming curcumin to produce tetrahydrocurcumin to relieve nervous anxiety, and belongs to the technical field of microorganisms. The lactobacillus delbrueckii subsp. Bulgaricus CCFM1520 screened by the invention has the capability of converting curcumin, and can utilize curcumin and generate tetrahydrocurcumin. The invention further provides a synbiotic preparation prepared from the lactobacillus gasseri CCFM1481 and curcumin, the synbiotic preparation can be used as an anti-fatigue functional medicine, the individual behavioral memory level can be improved, the imbalance of body neurotransmitters (DA, 5-HT and NE) can be slowed down, the expression of body neuroprotection related genes (BDNF, TrkB, DRD1 and TH) can be improved, and the synbiotic preparation has a huge application prospect.

The application discloses an oil-in-water gel Pickering emulsion, a preparation method and application, and comprises the following steps: step 1, dispersing liquid oil and beeswax to obtain an oil gel; step 2, adding nanocellulose whiskers into a sodium alginate solution, and fully mixing to obtain an aqueous phase solution; wherein the mass ratio of the sodium alginate and the nanocellulose whiskers is 2-10:5; step 3, fully mixing and dispersing the oil gel in step 1 and the aqueous phase solution in step 2 to obtain the required oil-in-water gel Pickering emulsion; the oil-in-water gel Pickering emulsion obtained by adding the sodium alginate and the modified CNW as emulsifiers has a significantly improved ability of embedding and delivering curcumin, and the chemical stability and the bio-accessibility of the curcumin are improved.

This application belongs to the field of biomedicine, specifically relating to a method for preparing an antitumor composition for pets, aiming to solve the technical problems of low bioavailability, poor stability, and poor drug administration compliance of poorly soluble active ingredients in antitumor drugs for pets. The method includes: a raw material pretreatment step, in which curcumin, resveratrol, quercetin, green tea polyphenols, and astragalus polysaccharides are pulverized and sieved separately; an organic phase preparation step, in which egg yolk lecithin and solid lipids are dissolved in an ethanol-acetone mixed solvent, and curcumin and resveratrol are added and dissolved by stirring in a water bath; an aqueous phase preparation step, in which poloxamer F68 is dissolved in purified water and dissolved in a water bath; a high-pressure homogenization step, in which a nanoemulsion containing a solid lipid core is prepared; a moderately polar component encapsulation step, in which quercetin and green tea polyphenols are ultrasonically dispersed and then added dropwise to the nanoemulsion; a freeze-drying step, in which a nano-lyophilized powder is obtained; and an outer hydrophilic component coating step, in which astragalus polysaccharides are sprayed or adsorbed onto the surface of the freeze-dried powder. The composition obtained by this method is a core-shell multilayer nanoparticle with a core consisting of curcumin and resveratrol encapsulated by solid lipids, a middle shell adsorbing quercetin and green tea polyphenols, and an outer shell coated with astragalus polysaccharides. This application utilizes the above-mentioned layered encapsulation technology to achieve stable co-encapsulation of multiple antitumor active ingredients, improve the bioavailability of poorly soluble components, optimize drug stability, and enhance antitumor effects through multi-target synergistic effects. Simultaneously, it endows the composition with immunomodulatory functions and sustained-release properties. The composition can be formulated into a nano-lyophilized powder form, making it easy to add to pet food or formulate into a paste for administration, improving pet drug compliance. Figure 2 is a schematic diagram of the three-layer core-shell nanoparticle structure of the composition of this invention.

The invention relates to the technical field of deep processing of natural products, in particular to water-soluble turmeric with low hygroscopicity and high stability and a preparation method and application thereof. The preparation method comprises the following steps: mixing and cross-linking a curcumin-ethanol solution and a chitosan-acetic acid solution, and drying to obtain curcumin-chitosan compound nanoparticles; and adding the nano-particles into a wall material solution containing starch sodium octenylsuccinate, maltodextrin, high-branched-chain cyclodextrine and hydroxypropyl starch, emulsifying, homogenizing at high pressure, performing wet grinding and drying to obtain the water-soluble turmeric with low hygroscopicity and high stability. The prepared product is good in water solubility, high in turmeric content, good in stability, not prone to moisture absorption and caking in the high-temperature and high-humidity environment and good in fluidity, solves the problems of moisture absorption, caking and the like of water-soluble powder turmeric products after being transported for a long time in the high-temperature and high-humidity environment, and is suitable for the fields of food, medicine, cosmetics and the like.

The application belongs to the technical field of biological medicine, and particularly relates to a biomimetic nano delivery system based on MRSA outer vesicle coating and application thereof. The application first couples chitosan oligosaccharide and monocarboxylated curcumin through an amide reaction to synthesize an amphiphilic polymer carrier, then loads vancomycin, daptomycin and other drugs through self-assembly to obtain a drug micelle, and finally coats the drug micelle with MRSA outer vesicle to successfully prepare a targeted biomimetic nano delivery system. The prepared biomimetic nano delivery system has excellent antibacterial effect, can realize targeted delivery and long-acting release of antibacterial drugs at an infection site, and is expected to overcome the bottleneck of drug resistance and insufficient drug penetration in traditional treatment, and provides a potential solution for the treatment of diseases such as periprosthetic infection.

The invention belongs to the technical field of functional food, and particularly relates to a donkey-hide gelatin peptide-iron chelate preparation and a preparation method thereof. The preparation method comprises the following steps: adding colla corii asini powder into water, and melting by heat to obtain a colla corii asini stock solution; adding protease into the colla corii asini stock solution for enzymolysis to obtain colla corii asini enzymatic hydrolysate; bOC-L-cysteine-curcumin, tetrabutylammonium bromide and iodine are added into the colla corii asini enzymatic hydrolysate, a sodium hydroxide solution with the concentration of 0.1 mol / L is adopted for adjusting the pH value, then a reaction is conducted, and a colla corii asini enzymatic hydrolysate retreatment solution is prepared; ascorbic acid is added into the donkey-hide gelatin enzymolysis retreatment liquid, the pH is adjusted with a 10% hydrochloric acid solution, then ferrous chloride is added, centrifugation is carried out after chelation, nanofiltration treatment is carried out, and a nanofiltration concentrated solution is a donkey-hide gelatin peptide-iron chelate; and uniformly stirring and mixing the colla corii asini peptide-iron chelate and genkwanin to obtain the colla corii asini peptide-iron chelate

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.

The invention provides an anti-cancer medicine and food homologous composition and a preparation method thereof. The composition is prepared from the following components in parts by weight: 5 to 10 parts of lipoic acid, 30 to 50 parts of nano curcumin, 2 to 7 parts of berberine, 50 to 100 parts of beta-glucan, 15 to 35 parts of polymethylacrylic acid, 15 to 25 parts of herba hedyotidis diffusae extract, 7 to 15 parts of scutellaria barbata baicalein, 25 to 55 parts of astragalus polysaccharide, 8 to 18 parts of coix seed ester and 10 to 15 parts of cordyceps cicadae. Through a space-time targeting synergistic release mechanism of a bionic nanocellulose skeleton and in combination with pH / enzyme double-response intelligent regulation and control, three-stage precise synergistic effects of oxidation resistance, apoptosis promotion and immune activation are realized, the limitation that a traditional medicinal and edible composition is poor in targeting property, low in synergistic efficiency and uncontrollable in toxicity is broken through, and the medicinal and edible composition has a broad application prospect. High-efficiency and low-toxicity tumor multi-channel synergistic intervention is achieved in a natural component system for the first time, and the actual effect of the whole medicinal and edible composition on cancer and swelling resistance is improved.