2239 results about "Curcumin" patented technology

Disclosed are improvements in human nutrition involving a unique combination of natural products constituting anti-inflammatory compositions which can reduce cardiovascular disease risks as well as play a positive role in other conditions and diseases for which key indicators, especially selected from the group consisting of C-reactive protein (CRP) levels, cyclooxygenase-2 (COX-2), 5-lypoxygenase (5-LOX) expression and prostaglandin E2 (PGE-2) biosynthesis or any combination of these, are indicators. Therapeutic compositions preferably comprise curcumin, bilberry extract, grape seed extract, green tea extract and apple extract, in effective amounts individually and combined to provide a therapeutically significant reduction in one or more key indicators. Another exemplified therapeutic composition comprises: omega-3 rich refined fish oil, resveratrol, blueberry extract, grape seed extract, green tea extract and gamma and / or delta tocopherol, in effective amounts individually for the above benefits.

The invention relates to a cosmetic or dermatological composition containing a carrier comprising at least one fatty phase characterized in that it contains at least one derivative or a mixture of derivatives of 1,7-diphenyl-3,5-heptanedione having a particular structure and at least one oil having, in its structure, at least one amide unit.The invention also relates to its uses in cosmetics and dermatology, in particular for preventing or combating the harmful effects of UV radiation and pollution on human keratinous materials, and more particularly for preventing and / or treating photoaging of the skin.The invention also relates to a method for solubilizing a derivative or a mixture of derivatives of 1,7-diphenyl-3,5-heptanedione having a particular structure with at least one oil having, in its structure, at least one amide unit.

Curcumin analogues and methods are provided for treatment of disease.

Dietary, health, and / or nutritional supplements provide various formulations of mushrooms grown in fermented soy, with or without rice flour, optionally in combination with sweetener(s), curcumin, and various other herbs and spices. Certain embodiments or compositions may be in liquid, beverage, solid, paste or powder forms. In certain embodiments the supplements contain mushroom species grown in fermented soy in the presence of certain bacterial species and optionally rice or rice flour. In some embodiments, other ingredients that may be present include one or more of curcumin, desmethoxycurcumin and bis-desmethoxycurcumin or all three curcumins. Certain embodiments may be used to treat or provide symptomatic relief from a variety of maladies ranging from malnutrition to mood related disorders to metabolic support and other more severe conditions as described herein.

Several diterpene glycosides (e.g., rubusoside, rebaudioside, steviol monoside and stevioside) were discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds, including but not limited to, paclitaxel, camptothecin, curcumin, tanshinone HA, capsaicin, cyclosporine, erythromycin, nystatin, itraconazole, and celecoxib. The use of the diterpene glycoside rubusoside increased solubility in all tested compounds. The diterpene glycosides are a naturally occurring class of water solubility-enhancing compounds that are non-toxic and that will be useful as new complexing agents or excipients in the pharmaceutical, agricultural (e.g., solubilizing pesticides), cosmetic and food industries. Aqueous solutions by using rubusoside to increase the solubility of otherwise insoluble drugs will have several new routes of administration. In addition, aqueous solutions of therapeutic compounds with rubusoside were shown to retain the known pharmacological activity of the compounds.

The invention provides a curcumin oral emulsion and injection, wherein the emulsion comprises curcumin, oil, emulsifying agent and water, the injection also contains isotonic agent. The invention also discloses the process for preparing the emulsion and its use in preparing medicaments for treating or preventing tumor, resisting tumor transfer, enhancing curative effects of chemotherapy drugs, reducing side effects of chemotherapy and improving immunity functions for tumor patients.

Cancer or a precancerous condition is treated by administering a curcumin derivative to a subject.

A curcumin analog in which natural curcumin is modified by an amino acid moiety that increases the analog's transport across the blood brain barrier by the LAT1 transporter.

A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a curcuminoid species and an effective amount of a second component selected from the group consisting of an alpha-acid species or a beta-acid species or derivatives thereof. The composition provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.

Enhanced methods have been discovered, using either sonication or homogenization followed by increased temperature and pressure, to solubilize compounds using diterpene glycosides and to produce a powder form of the compound-solubilizer complex than can be reconstituted in water. Without the diterpene glycoside, the compounds were insoluble or sparingly soluble in water, including some fat-insoluble vitamins. Water solutions of these compounds were made using a diterpene glycoside solubilizer, for example, rubusoside. The compound-solubilizer complex was then dehydrated to a stable powder that could then be reconstituted with water. A reconstituted drug-solubilizer complex (curcumin-rubusoside) was shown to be effective on reconstitution. In addition, the diterpene glycoside, rubusoside, was shown to be an inhibitor of permeability glycoprotein (P-gp), and will thus increase gastrointestinal absorption of certain drugs administered with rubusoside.

Pharmaceutical compositions suitable for aerosol delivery to a subject that include curcumin dispersed in a lipid vehicle, wherein the lipid has a transition temperature of less than about 15° C., are disclosed. In addition, methods of treating a pathological condition in a subject that include providing one of the claimed pharmaceutical compositions and administering the composition to the subject are disclosed. For example, the pathological condition can be a hyperproliferative disease, such as cancer, an inflammatory disease, or a pulmonary disease.

The invention relates to a curcumin-polysaccharide conjugate as well as a preparation method and application thereof. The preparation method comprises the following steps of: grafting amino acid at one terminal of a diamine compound to polysaccharide through amidation to obtain a polysaccharide macromolecule with a free terminal of amino acid; and introducing curcumin on the polysaccharide frame by a Schiff base reaction. The preparation method is characterized in that 1, the water solubility and in-vivo and in-vitro stability of the curcumin can be improved due to grafting modification on the curcumin, and the generated curcumin-polysaccharide conjugate can be used as a novel macromolecular medicament indepterminalently; 2, the curcumin-polysaccharide conjugate has a strong oral absorption promoting effect, is high in safety, and can achieve the effects of promoting medicament absorption, improving the curative effect, reducing the toxic and side effect of the conjugate and the like; and 3, the amphipathy of the polysaccharide molecule is improved by introducing the hydrophobic group curcumin, so that the curcumin-polysaccharide conjugate can be self-assembled into nano-micelle, and can be used as a vector of an insoluble medicament. The preparation method is simple, low in cost, and applicable to large-scale continuous production.

Disclosed are methods of treating, preventing, modulating, attenuating, or inhibiting a disease or a disorder associated with inflammation related to NF-κB activation in a subject which comprises administering to the subject at least one curcumin compound. Also disclosed are combination therapies comprising the administration of at least one curcumin compound and at least one ROS inhibitor. Pharmaceutical compositions and kits are also disclosed.

An efficient broad-spectrum low-poison vegetative agricultural bactericide in the form of emulsified oil, microemulsion, aquatic emulsion, or soluble liquid is prepared from asarum herb, turmeric and flavescent sophora root. Its preparing process is also disclosed.

This invention relates to curcumin analogs and their applications. Curcumin is an excellent precursor compound, and has multiple pharmaceutical activities. The curcumin analogs in this invention have more stable monocarbonyl intermediate connection chain structure. The connection chain can be acetone, cyclopentanone or cyclohexanone. The substituent on benzene ring can be separately selected from H, hydroxyl, halogen, alkoxyl, alkyl, halogenated alkyl, amino, and alkyl amino. This invention also discloses pharmaceutically acceptable salts of the curcumin analogs, preparations containing them, and their pharmaceutical applications. Experiments show that the curcumin analogs can be used to treat inflammation and tumor.

Curcumin has shown anti-inflammatory and anti-angiogenic properties that could be useful in treating various diseases such as those of rheumatology and oncology. However, curcumin is very poorly absorbed and has a very low bioavailability. This patent describes a method of increasing the delivery of curcumin by complexing it with cyclodextrins. Cyclodextrins are well known in the food industry and have been used to carry other drugs to increase bioavailability. The new combination of cyclodextrins and curcumin has been tested in pre-clinical inflammation models where it has demonstrated efficacy superior to both the positive control and curcumin.

The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on Aβ aggregation, a degradative effect on Aβ aggregates, an inhibitory effect on β-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof:wherein R1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R2 represents a 1H-indol-6-yl group or the like.

This invention describes the use of resveratrol and curcumin, representatives of naturally occurring polyphenols, in their native form, after hydrogenation, and as their respective allyl derivatives, individually, in combination with themselves and other commercial monomers, to make representative varieties of polymers, e.g., polycarbonates (PC), polyurethanes (PU), co-polymers and biodegradable polymers.

A dietary supplement is created, comprised of material from the following nutrients, vitamins, herbs, minerals, and food and plant substances and food and plant derivatives: lycopene, vitamin E, selenium, green tea, coenzyme Q10, garlic, folic acid, vitamin C, curcumin, seaweed, Cordyceps sinsensis mushroom, Lentinus edodes (shiitake) mushroom, and Ganoderma lucidum (reishi) mushroom. The composition is administered orally for individuals who wish to reduce their risk of disease, particularly cancer-risk.

It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.

The invention provides a broad-spectrum nitric oxide free radical health care product, comprising the following components by weight on a daily basis: 4-6g of L-arginine, 200-1000mg of L-citrulline, 1-25g of cooked soybean meal, 80-100mg of pycnogenol (pine bark extract), 100-150mg of grape seed extracts, 100-150mg of EGB761 (extract of ginkgo biloba), 500mg of curcumin, 500mg of vitamin C, 200-400mg of vitamin E, 20-30mg of beta-carotene, 800mu g of folic acid (containing calcium folinate) and 100mu g of selenium. The health care product not only has the effect of generating the nitric oxide free radical, but also can protect the activity and the stability of the nitric oxide free radical, provides corresponding health care and auxiliary treatment formulas according to different individuals to achieve obvious health care effect, and has specific curative effects on the diseases.

The invention relates to a curcumin nano micelle preparation and a preparation method thereof. The preparation consists of curcumin and amphiphilic block copolymer. The preparation method comprises the following steps of: jointly dissolving the curcumin and the amphiphilic block copolymer in an organic solvent, performing rotary evaporation to remove the organic solvent, performing vacuum drying on the obtained a medicine-containing film, sanding overnight, removing residual organic solvent, adding an aqueous phase, combining ultrasonic dispersion and 35-38 DEG C thermostatic oscillation to obtain a micelle solution, centrifuging at a high speed, and taking supernate, namely the curcumin nano micelle preparation. The curcumin nano micelle preparation is prepared by an improved film dispersion method, the solubility of the curcumin in water is improved, the loading rate of the preparation can reach 8 percent, the micelle particle size is less than 100nm, and the curcumin nano micelle preparation has the advantages of stable structure, small particle size, low toxicity, high safety, long in-vivo circulation time, simple storage and the like.

A curcumin medicine for preventing and treating cancer and cardiovascular and cerebrovascular disease includes a pre-concentrated curcumin liquid in the form of softgel and prepared from the precursor of curcumin and emulsifier and a fatty curcumin emulsion prepared from the precursor of curcumin, emulsifier, antioxidant, isotonic regulator, stabilizer, pH regulator, and the water for injection. It can also provide energy to the patient.

The invention discloses a method for preparing a nanofibre membrane, belonging to a technique for preparing a nanofibre compound membrane. The method comprises the following steps: preparing curcuminethanol solution and chitosan acetum, mixing the curcumin ethanol solution and the chitosan acetum by the volume ratio thereof to prepare spinning solution which is injected into an injector of an electrostatic spinning device for electrostatic spinning to form a compound nanofibre membrane and to obtain a curcumin / chitosan nanofibre membrane of antibacterial property, wherein the diameter of thecurcumin / chitosan nanofibre membrane is 200-400 nm. The invention has the advantages that the preparation process is simple, the prepared membrane material heals wound, has broad spectrum bactericidalproperty and has higher bacterial inhibition rate to colibacillus and staphylococcus aureus for 24h.

The self microemulsified curcumin preparation consists of curcumin, surfactant, co-surfactant, oil phase and solid adsorbent. The self microemulsified curcumin preparation may be prepared into capsule or granule for orally taking, and the capsule or granule under the action of gastrointestinal fluid may be self microemulsified to form liquid drops with size below 100 nm. Therefore, the present invention has increased curcumin solubility and absorption in gastrointestinal tract and raised bioavailability.

The invention provides a natural pigment composition. The natural pigment comprises an emulsifier and two or more than two pigments of gardenia yellow pigment, curcumin, carithamine, citroxanthin, xanthophyll, riboflavin, capsaicin, monascus red pigment, bixa orettana pigment and gardenia blue. Natural pigments can prepare natural pigment compositions in different color systems and different tones in arbitrary proportions, such as yellow, orange, red, green and purple. Meanwhile, the natural pigment composition contains the emulsifier, so that the composition can be more uniform and more stable. Therefore, in the natural pigment composition provided by the invention, combinations of different natural pigments can overcome the defect of single pigment, for example, the light resistance of natural yellow pigment combined by the riboflavin, the curcumin and the like with poor light resistance and the gardenia yellow pigment with more stable light resistance is better than that of the riboflavin or the curcumin, thus the dosage can be reduced, and the cost can be reduced.

The invention discloses a type of amino acid modified curcumin, a synthesis method thereof, and an application thereof. According to the invention, structural modification is carried out upon curcumin by using natural amino acid, such that 1-(4-hydroxy-3-methoxyphenyl)-7-(4-oxyacetyl amino carbobenzoxy-3-methoxyphenyl)-1,6-heptadiene-3,5-diketone which is represented by a general formula (I) is obtained. With an MTT method, evaluation is carried out upon the compound represented by the general formula (I) in the inhabitance of proliferation activities of four cells which are K562, H22, HL60 and S180. IC50 values of the compound represented by the general formula (I) in inhibiting the proliferations of the four tumor cells are calculated. As a result of experiments, with the compound represented by the general formula (I), proliferations of tumor cells can be substantially inhibited. The compound has excellent anti-tumor activity, and can be prepared into anti-tumor medicines.

A ready-to-use water dispersible pigment composition containing at least 5% by weight of water is provided. The composition comprises a stable dispersion of a water-insoluble and / or hydrophobic natural pigment such as a carotenoid, curcumin, a porphyrin pigment or vegetables carbon black in the form of bodies of an average size which is at the most 10 mum is provided. The pigment bodies are dispersed without the use of a surface active substance in an aqueous phase comprising a hydrocolloid. The natural pigment in compositions which are useful for coloring of food products and pharmaceuticals do not migrate in the products. The compositions are useful in coating compositions for tablets and dragees.

The invention provides a compound feed capable of improving the fatty liver and body colour of the marine fish. The compound feed comprises a premixed feed, a bile acid, curcumin and betaine, wherein the premixed feed comprises fish meal, soya bean meal, corn gluten meal, high protein flour, corn, shrimp shell meal, monocalcium phosphate, fish oil, liquid phosphatide, vitamin premixes, mineral premixes, and the like. Artificial marine-fish breeding experiments prove that the compound feed provided by the invention can meet the nutritional needs of marine-fish growth, effectively enhance the physique of the marine fish, improve the immunity of the marine fish, reduce the incidence of a fatty liver disease, and improve the body color of the marine fish, so that the body color of the marine fish is bright-colored and close to a wild natural color, thereby enhancing the quality of artificially cultured marine fish.

A curcumin-phosphotide composition is prepared from curcumin or its derivative and phosphotide through proportional compounding. Its advantage is high utilization rate of curcumin. Its preparing process is also disclosed.