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1046 results about "Curcumin" patented technology

Curcumin is a bright yellow chemical produced by Curcuma longa plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.

Composition with effects of protecting liver and resisting oxidation and preparation method thereof

The invention relates to the technical field of pharmaceutical preparations, and discloses a composition with liver protection and antioxidation effects and a preparation method thereof.The composition is prepared from galactosamine modified astragalus membranaceus exosome, schisandra chinensis nanocrystals, liquorice-chitosan nanoparticles, lactobacillus acidophilus freeze-dried powder, beta-(1, 3) / (1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate) sourced from saccharomyces cerevisiae, and beta-(1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate). And (6) a dextran, grape exosome-curcumin hybrid vesicle freeze-dried powder, a curcumin-mitochondrial targeting peptide compound, a resveratrol-hydroxypropyl-beta-cyclodextrin inclusion compound and reduced panthenol. According to the liver-protecting and anti-oxidation composition disclosed by the invention, multi-dimensional intervention on liver protection is realized through an elaborately designed ternary system. The system is composed of a traditional Chinese medicine extract, a microorganism-plant exosome combination and a high-bioavailability antioxidant, all the parts have a synergistic effect, and the liver protection effect is remarkably improved.
Owner:BEIJING FUTAIMING BIOTECHNOLOGY CO LTD

Bacillus velezensis JNJK-1, microbial agent and application of bacillus velezensis JNJK-1 in edible fungus disease control

The invention relates to the technical field of biological control, in particular to bacillus velezensis JNJK-1, a microbial agent and application of the bacillus velezensis JNJK-1 and the microbial agent in edible fungus disease control, the bacillus velezensis JNJK-1 is preserved in China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CMCC No.31075. The novel bacillus velezensis JNJK-1 is screened out for the first time, and the bacillus velezensis can be applied to biological control of edible mushroom diseases and has a broad-spectrum inhibition effect on pathogenic bacteria of edible mushrooms. Meanwhile, the inventor also finds that the bacillus velezensis JNJK-1, curcumin and sodium alginate are compounded into the microbial agent, so that the inhibition effect on the pathogenic bacteria of the edible fungi can be improved, and the microbial activity can be maintained.
Owner:JINING ACAD OF AGRI SCI

Janus wound dressing with antibacterial and tissue repair promoting functions and preparation method thereof

The invention discloses a Janus wound dressing with antibacterial and tissue repair promoting functions and a preparation method of the Janus wound dressing, belongs to the technical field of wound dressings, and aims to realize antibacterial, tissue repair promoting and moist wound healing microenvironment through freeze drying and electrostatic spinning technologies. Polycaprolactone (PCL), bioactive glass (BG) and curcumin Cur are used for preparing a hydrophobic inner layer capable of promoting tissue repair, methacrylated gelatin GelMA is used for preparing a hydrophilic outer layer with moisturizing performance, and the PCL-BG-Cur / GelMA composite wound dressing with antibacterial, moisturizing and repair promoting functions is constructed. Animal experiment results show that the dressing loaded with curcumin Cur and bioactive glass BG has multiple functions of synergistic antibiosis, moisturizing and the like, the result shows that the prepared dressing has the performance of promoting epithelization, collagen deposition, new hair follicle formation and the like, and the dressing has a considerable application prospect in the aspect of rapid wound repair.
Owner:GUIZHOU UNIV +1

Metal organic framework composite material based on gamma-cyclodextrin as well as preparation and application of metal organic framework composite material

The invention provides a gamma-cyclodextrin-based metal organic framework composite material as well as preparation and application thereof. The metal organic framework composite material based on gamma-cyclodextrin comprises chitosan, gamma-CD-MOFs (Metal Organic Frameworks) and an active substance. The preparation method comprises the following steps: by taking chitosan as a film material base material, synthesizing gamma-CD-MOFs by utilizing a hydrothermal method, and then loading cinnamyl aldehyde with antibacterial property, 2-methoxycinnamyl aldehyde with ultraviolet light resistance and curcumin with an antioxidant effect into the gamma-CD-MOFs. And finally, mixing with chitosan with better film-forming property, and spraying on glass or the surfaces of fresh fruits. The gamma-CD-MOFs has the characteristic of slowly releasing bioactive substances, is non-toxic and is a material capable of being applied to food packaging.
Owner:BEIJING TECH & BUSINESS UNIV +2

Composition for promoting hair regeneration after chemotherapy as well as preparation method and application of composition

The invention provides a composition for promoting hair regeneration after chemotherapy as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: modifying the surface of a gold nanocage with polydopamine, loading the modified gold nanocage on an exosome, complexing magnesium ions and zinc ions to prepare a modified exosome, preparing a nano drug-loaded liposome from curcumin, resveratrol and epigallocatechin gallate, mixing the nano drug-loaded liposome with the modified exosome to prepare a multi-layer liposome, and preparing the multi-layer liposome from the nano drug-loaded liposome. And mixing with a penetration enhancer, and adding into a temperature-sensitive hydrogel system to prepare the composition for promoting hair regeneration after chemotherapy. The composition for promoting hair regeneration after chemotherapy has a good transdermal absorption promoting effect, can slowly release drugs, promotes hair follicles to be converted from a resting stage to a growing stage under the synergistic effect of the drugs, regulates and controls multiple pathways (such as anti-apoptosis, angiogenesis promotion and anti-inflammation) at the same time, is matched with a complex pathological mechanism of hair regeneration after chemotherapy, and can promote hair regeneration after chemotherapy. Wide application prospects are realized.
Owner:YANG SERIES (SHANDONG) BIOTECHNOLOGY CO LTD

Preparation method of curcumin-loaded glycosylated casein high internal phase emulsion based on enzymatic method

The invention discloses a method for preparing a high internal phase emulsion and delivering curcumin by using transglutaminase mediated casein-carboxymethyl chitosan covalent substances, aims to improve the stability and bioaccessibility of curcumin, and belongs to the field of food processing. The method comprises the following steps: firstly, carrying out ultrasonic treatment on sodium caseinate for a certain time, and carrying out transglutaminase cross-linking reaction on sodium caseinate and carboxymethyl chitosan to obtain a casein-carboxymethyl chitosan covalent substance; and then adding the mixture into the curcumin-loaded corn oil according to a certain proportion, and homogenizing to obtain the curcumin-loaded high internal phase emulsion. The emulsion has good interface characteristics and can effectively encapsulate curcumin. The preparation process is simple, efficient, green and environmentally friendly, the prepared high internal phase emulsion has high stability and good biological accessibility, a new technical means is provided for delivery of curcumin, and the high internal phase emulsion has wide application prospects in the field of food.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

Curcumin-loaded pectin sodium alginate gel as well as preparation method and application thereof

The invention relates to curcumin-loaded pectin sodium alginate gel as well as a preparation method and application thereof, and belongs to the technical field of gel preparation. The preparation method of the curcumin-loaded pectin sodium alginate gel comprises the following steps: in a dark environment, stirring and mixing curcumin, arjunic acid, ortho-aminophenol and an organic solvent, adding a polyvinyl alcohol aqueous solution, a sodium alginate solution and a pectin solution, uniformly mixing, performing ultrasonic treatment, adding calcium chloride, stirring and mixing, performing ultrasonic treatment, and performing vacuum drying to obtain the curcumin-loaded pectin sodium alginate gel. And adding oxidized hyaluronic acid, continuously stirring, stirring at normal temperature until the organic solvent is completely volatilized, and cleaning the hydrogel with deionized water to obtain the hydrogel. According to the invention, calcium ions and sodium alginate are subjected to physical crosslinking, pectin and polyvinyl alcohol are combined to form a composite hydrogel layer, the compounding of multiple components can effectively control the dissolution and drug release behaviors of active components, the bioavailability of curcumin is increased, the compactness and stability of hydrogel are increased, and the bioavailability of curcumin is improved. The oxidation resistance of the hydrogel can be effectively improved.
Owner:SHANDONG BUSINESS INST

Beta-glucuronidase inhibitor composition as well as preparation method and application thereof

The invention discloses a beta-glucuronidase inhibitor composition as well as a preparation method and application thereof. The composition is prepared from the following substances: ursolic acid, procyanidine, icariin, curcumin, epigallocatechin gallate and glycyrrhetinic acid. The beta-glucuronidase inhibitor composition has a broad-spectrum and good inhibition effect, the preparation method is simple, large-scale production is easy, and the inhibitor with a natural source is higher in use compliance, lower in toxic and side effects and more suitable for developing intestinal health products and has an application prospect.
Owner:CHINA PHARM UNIV

Eutectic solvent for promoting ultra-high dissolution of curcumin and preparation method of eutectic solvent

The invention discloses a eutectic solvent for promoting ultrahigh dissolution of curcumin and a preparation method of the eutectic solvent, relates to the technical field of chemical preparations, and aims to solve the technical problem of relatively low solubility of curcumin in a solvent in the prior art. The preparation method of the eutecticevaporate solvent for promoting ultrahigh dissolution of curcumin comprises the following steps: mixing a hydrogen bond donor, a hydrogen bond acceptor and other components, and heating to a first preset temperature to obtain a clear and transparent eutecticevaporate solvent; and heating the eutectic solvent to a second preset temperature, adding curcumin powder, carrying out rapid vortex dissolution, centrifuging, and collecting a supernatant to obtain a clear and transparent high-solubility curcumin solution. According to the method, the green solvent is adopted as a medium, no additional substance needs to be added, operation is easy and convenient, the solubility of the curcumin is remarkably improved, and therefore the application range of the curcumin in the fields of cosmetics, food and pharmacy is expanded.
Owner:SOUTH CHINA UNIV OF TECH

Biphase drug-loaded Pickering emulsion with stable silk fibroin nanoparticles and antibacterial application of biphase drug-loaded Pickering emulsion

The invention belongs to the technical field of functional Pickering emulsion preparation, and particularly discloses a silk fibroin nanoparticle-stabilized biphase drug-loaded Pickering emulsion and an antibacterial application thereof. The curcumin-loaded silk fibroin nanoparticles Cur-SFNPs with uniform form and size are prepared by using an anti-solvent precipitation method. In order to improve the antibacterial effect of the Pickering emulsion, the Cur-SFNPs is utilized to stabilize the soybean oil loaded with resveratrol, and the oil-in-water type Pickering emulsion is prepared. The Pickering emulsion prepared by taking Cur-SFNPs as a stabilizer has the characteristics of small particle size, uniform distribution, storage stability, heating stability, freeze-thaw stability, food safety and environmental friendliness. And as a two-phase drug-loaded emulsion, two natural hydrophobic active drugs are loaded at the same time, so that the solubility and bioavailability of the emulsion can be enhanced, the loaded active substances play a synergistic antibacterial and antioxidant role, and the emulsion can be applied to food preservation.
Owner:CHANGZHOU UNIV

Slow-release antibacterial reinforced composite film for fresh keeping of fruits and vegetables and preparation method of slow-release antibacterial reinforced composite film

The invention provides a slow-release antibacterial enhanced composite film for fruit and vegetable preservation and a preparation method thereof, and the preparation method comprises the following steps: performing sulfonation modification treatment on nano cellulose powder to obtain sulfonated nano cellulose; carrying out quaternization modification treatment on the sulfonated nano-crystalline cellulose to obtain quaternary ammonium sulfonated nano-crystalline cellulose; adding gelatin and sodium carboxymethyl cellulose into deionized water to obtain a wall material solution, and adding curcumin into the wall material solution to obtain a prepolymer solution; stirring and emulsifying the prepolymer solution at a high speed to obtain a prepolymer suspension; adding a chitosan solution into the prepolymer suspension to obtain a microcapsule solution, adding tannic acid into the microcapsule solution to obtain a microcapsule suspension, and performing spray drying to obtain double-layer microcapsule powder; the preparation method comprises the following steps: uniformly mixing polylactic acid, quaternary ammonium sulfonated nanocellulose, the double-layer microcapsule powder, a plasticizer, a lubricant and an antioxidant to obtain a mixed material, and sequentially carrying out melt extrusion, cooling, pelletizing and film blowing.
Owner:中科纳美(天津)生物工程有限公司 +1

Protein-polysaccharide delivery system encapsulated curcumin as well as preparation method and application thereof in neuroprotection

The invention belongs to the technical field of food processing, and particularly relates to a curcumin-loaded protein-polysaccharide nanoparticle delivery system, a preparation method thereof and application of the curcumin-loaded protein-polysaccharide nanoparticle delivery system in neuroprotection. The preparation method comprises the following steps: mixing and dissolving sodium caseinate with one of glucan and pectin, hydrating at 0-4 DEG C for 12-24 hours, and performing ultrasonic and microwave treatment to obtain a pretreatment solution; adjusting the pH value, and heating the pretreatment solution to obtain covalent grafted particles; the protein-polysaccharide covalent grafted particles obtained in the second step are encapsulated with curcumin through a pH shift method, and the protein-polysaccharide-curcumin nanoparticles are obtained. The invention provides a method for carrying out Maillard reaction on sodium caseinate-polysaccharide under the assistance of ultrasound and microwaves, reaction parameters are optimized, and a preparation method of an efficient and stable curcumin delivery system and application of the curcumin delivery system in neuroprotection are constructed.
Owner:SOUTH CHINA UNIV OF TECH

PH responsive nanocellulose hydrogel as well as preparation method and application thereof

The invention discloses pH-responsive nanocellulose hydrogel and a preparation method and application thereof, and belongs to the technical field of hydrogel materials.The preparation method of the hydrogel comprises the following steps that firstly, an aldehyde cellulose nanofiber suspension and a carboxymethyl chitosan solution are mixed and stirred for 1-12 h at the temperature of 25-90 DEG C, and the molar ratio of amino to aldehyde is 1: 5-5: 1; 2, tannic acid and curcumin conjugated chitosan are added into the mixed solution of the aldehyde cellulose nanofibers and the carboxymethyl chitosan, the concentration of the tannic acid is 1-10 mg / mL, the concentration of the curcumin conjugated chitosan is 0.5-5 mg / mL, mixing and stirring are conducted, a cross-linking reaction is conducted, and the pH-responsive nanocellulose hydrogel is obtained. Based on the Schiff base bond effect in the hydrogel, the hydrogel has remarkable pH responsiveness, and by means of the hydrogen bond combination effect and synergistic effect among tannic acid, curcumin and nanocellulose, the hydrogel has good mechanical performance and antibacterial performance.
Owner:ANHUI SNOW DRAGON FIBER TECH CO LTD

An amorphous curcumin nanoparticle, a preparation method thereof, and an application thereof

The present invention discloses an amorphous curcumin nanoparticle and its preparation method and application. In the present invention, an absolute ethanol solution of curcumin and apple polyphenol is dropped into water under stirring, and then left standing for treatment to remove ethanol and adjust the pH to obtain amorphous curcumin nanoparticles. Through the bottom-up antisolvent precipitation method and the interaction between curcumin and polyphenol, and by optimizing the important conditions in the preparation process, the present invention effectively reduces the particle size of curcumin and transforms its crystal structure into an amorphous structure. At the same time, the amorphous curcumin nanoparticles can be used as an emulsifier for Pickering emulsions to prepare curcumin emulsions. Compared with curcumin nanoparticles, the curcumin emulsions have higher stability. The present invention has low energy consumption, reduced particle size, can improve solubility, enhance its bioavailability, improve its emulsifying properties, and has good application prospects.
Owner:SOUTH CHINA UNIV OF TECH

Compound probiotic preparation rich in organic selenium and preparation method thereof

The invention relates to the field of biological agents, in particular to a compound probiotic preparation rich in organic selenium and a preparation method of the compound probiotic preparation, and efficient synergistic delivery is achieved through plant micromolecule organic selenium extraction and a multi-layer microemulsion embedding technology. The preparation consists of a core active component, a carrier system and a curcumin compound. The plant micromolecular organic selenium is extracted from cardamine hupingshanesis and high-selenium corn flour through an HLUP technology, and the bioavailability is remarkably improved. A corn protein modified W / O / W microemulsion is adopted as a carrier, an outer layer membrane is stable in an acid environment, and an inner layer accurately releases selenium to small intestines; a protective agent composed of trehalose and glucose inhibits ice crystal damage, and glutaraldehyde crosslinking enhances the mechanical strength of the membrane. Curcumin and selenium synergistically enhance antioxidant and immunomodulatory functions, and promote phagocytic activity of macrophages. The stability and bioavailability bottlenecks of a traditional preparation are broken through, and an innovative scheme is provided for functional food development.
Owner:安徽中志现代食品科技有限公司

Chitosan-curcumin nano-composite preservative and preparation method thereof

The invention relates to the technical field of food fresh-keeping materials, in particular to a chitosan-curcumin nano-composite fresh-keeping agent and a preparation method thereof.The chitosan-curcumin nano-composite fresh-keeping agent comprises nano-particles of a chitosan-sodium alginate-oxidized sodium alginate interpenetrating network structure, according to the nanoparticles, protonated amino groups of chitosan and carboxyl groups of sodium alginate form a polyelectrolyte compound core, aldehyde groups of oxidized sodium alginate and amino groups of chitosan are subjected to a Schiff base reaction to form a chemical cross-linked network, and zinc ions, amino groups of chitosan, carboxyl groups of sodium alginate and carboxyl groups of oxidized sodium alginate form coordination cross-linking; curcumin and epigallocatechin gallate form a compound through a hydrogen bond and a hydrophobic effect, the compound is embedded in an interpenetrating network structure, beta-diketone groups of curcumin and zinc ions form chelating coordination, a chitosan-sodium alginate-oxidized sodium alginate ternary interpenetrating network is constructed, and the chitosan-sodium alginate-oxidized sodium alginate ternary interpenetrating network structure is formed. The stability is improved by utilizing the synergistic effect of triple mechanisms of electrostatic interaction, Schiff base chemical bonds and zinc ion coordination.
Owner:ZHONGSHAN NANFANG XINYUAN FOOD BIOENGINEERING CO LTD

Composition for dispelling effects of alcohol and protecting liver and application thereof

The invention relates to the field of food and health care products, and discloses a composition for dispelling effects of alcohol and protecting liver, which comprises 20-100 parts of ampelopsis grossedentata leaf extract; 50 to 200 parts of a radix puerariae extract; 10-50 parts of a semen hoveniae extract; 10-50 parts of a turmeric extract; 10 to 100 parts of a yeast extract; 5-50 parts of a licorice extract; and 5 to 20 parts of pyrroloquinoline quinone disodium salt. The ampelopsis grossedentata leaf extract, the kudzuvine root extract and the hovenia dulcis thunb extract are utilized, alcohol decomposition is promoted, the blood ethanol concentration is reduced, and drunkenness symptoms are relieved. Puerarin improves activity of liver metabolic enzymes, accelerates discharge of ethanol and acetaldehyde, and reduces liver damage. The anti-oxidation effects of dihydromyricetin and PQQ can eliminate alcohol metabolism free radicals and protect liver cells. The components such as puerarin, hovenia dulcis thunb, curcumin and glycyrrhizic acid jointly promote liver cell regeneration, inflammation and oxidative damage are reduced, the levels of ALT and AST in serum are reduced, and liver health is maintained.
Owner:EUGENE EXCELLENCE (TIANJIN) BIOMEDICAL TECH CO LTD

Aromatic soluble polymer microneedle as well as preparation method and application thereof

The invention relates to an aromatic soluble polymer microneedle as well as a preparation method and application thereof. The preparation method comprises the following steps: adding a zinc acetate hexahydrate aqueous solution and a Tris buffer solution into a eugenol-curcumin mixed ethanol solution to obtain self-assembled carrier-free nanoparticles containing eugenol and curcumin; and dissolving the nano-particles in a soluble hyaluronic acid solution, drying in a microneedle mold, and demolding to obtain the aromatic soluble polymer microneedle. The structure of the aromatic soluble polymer microneedle is that self-assembled carrier-free nanoparticles are wrapped in a soluble hyaluronic acid microneedle. Compared with the prior art, the aromatic soluble polymer microneedle prepared by the invention can overcome skin barrier and quickly absorb moisture and dissolve so as to promote the transdermal absorption effect of active substances; a perfume delivery system is constructed by using the soluble polymer microneedle, so that the biocompatibility is improved, the slow release control capability of the perfume can be effectively enhanced, and a new path is opened up for clinical application of inflammatory diseases.
Owner:SHANGHAI INST OF TECH

Curcumin-antibacterial peptide-tetrahedral framework nucleic acid compound as well as preparation method and application thereof

PendingCN119405822Aeffective treatmentreturn to normal structurePeptide/protein ingredientsAntipyreticPeriodontal ligament stem cellsOxidative stress
The invention provides a curcumin-antibacterial peptide-tetrahedral framework nucleic acid compound as well as a preparation method and application thereof, and belongs to the field of medicines. The curcumin-antibacterial peptide-tetrahedral framework nucleic acid compound is a compound prepared by taking curcumin, antibacterial peptide and tetrahedral framework nucleic acid as raw materials. Cell experiments show that the curcumin-antibacterial peptide-tetrahedral framework nucleic acid compound can significantly improve the osteogenesis activity of periodontal ligament stem cells, recover the mineralization activity, reduce the oxidative stress level and inhibit the occurrence and development of inflammatory reactions. Animal experiments show that the curcumin-antibacterial peptide-tetrahedral framework nucleic acid compound can significantly reduce loss of alveolar bones of periodontitis rats, inhibit the inflammatory state, promote osteogenic activity, recover the structure and quality of the alveolar bones and effectively treat periodontitis. The curcumin-antibacterial peptide-tetrahedral framework nucleic acid compound provided by the invention has a wide application prospect in preparation of drugs for preventing and / or treating periodontitis.
Owner:SICHUAN UNIV

Curcumin quantum dot as well as preparation method and application thereof

The invention relates to a curcumin quantum dot, a preparation method thereof and application of the curcumin quantum dot in preparation of a tumor diagnosis and treatment integrated reagent. The curcumin quantum dot comprises a reaction product formed by performing a Schiff base reaction on curcumin and a polyamino ligand in the presence of a dehydrating agent, wherein the average diameter of the curcumin quantum dot is 1-30nm. The curcumin quantum dot provided by the invention can greatly improve the solubility, biocompatibility and antitumor activity of single curcumin.
Owner:THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV

Antibacterial and mildew-proof PP plastic and preparation method thereof

InactiveCN119842154APolymer sciencePlasticizer
The invention belongs to the technical field of plastics, and particularly relates to an antibacterial and mildew-proof PP plastic and a preparation method thereof. The polypropylene composite material comprises the following components in parts by weight: 100 parts of polypropylene resin; 4-8 parts of a dispersant; 2-4 parts of a plasticizer; 1-2 parts of an antioxidant; 2 to 6 parts of Co-TCPP-curcumin MOFs (metal organic frameworks); and 3 to 7 parts of CTAB modified zinc-aluminum hydrotalcite. According to the invention, the cobalt-based metal organic framework containing curcumin is prepared to promote the improvement of the antibacterial and mildew-proof properties of the PP plastic, and the zinc-aluminum hydrotalcite is modified by CTAB, so that not only is the dispersity of the magnesium-aluminum hydrotalcite improved, but also the improvement of the antibacterial property is promoted. The prepared PP plastic is excellent in performance and good in prospect.
Owner:GUANGZHOU SENJIAN NEW MATERIAL TECHNOLOGY CO LTD

Curcumin delivery system based on small extracellular vesicles, preparation method and application

The invention particularly relates to a curcumin delivery system based on small extracellular vesicles, a preparation method and application. Curcumin has the defects of poor water solubility, poor chemical stability and insufficient targeting, in order to improve the bioavailability of curcumin, the curcumin delivery system based on small extracellular vesicles provided by the invention adopts RGD peptide surface modified sEVs as a carrier to coat curcumin, and saponin is used for assisting ultrasonic drug loading, so that the drug loading rate of curcumin is improved. According to verification of the invention, the delivery system can effectively improve the in-vitro release performance of the curcumin preparation and realize controlled release and slow release. Meanwhile, the delivery system effectively improves apoptosis induction of curcumin to glioma cells, the blood-brain barrier penetrating capacity of the curcumin delivery system is improved, and the treatment effect on brain glioma is expected to be improved.
Owner:LIAOCHENG PEOPLES HOSPITAL

Curcumin-loaded brain-targeted drug delivery system as well as preparation method and application thereof

PendingCN119587703Areserved functionStrong targetingNervous disorderSolution deliveryCerebral paralysisCyclodextrin
The invention discloses a curcumin-loaded brain-targeted drug delivery system as well as a preparation method and application thereof. The delivery system comprises a carrier macrophage and a curcumin drug, the curcumin nano-drug is prepared by encapsulating curcumin with a lipoic acid modified cyclodextrin conjugate, then macrophages and the curcumin nano-drug are mixed, and co-incubation is carried out, so that the curcumin nano-drug is constructed. The brain-targeted macrophage drug delivery system loaded with curcumin is a multifunctional composite drug with brain targeting property for treatment of cerebral arterial thrombosis. A brain-targeted macrophage drug delivery system loaded with the curcumin nano-drug gathers in cerebral apoplexy tissues, phenotypic transformation of inflammatory microglial cells is promoted, and a pro-inflammatory microenvironment is improved; the oxidative stress pressure of the stroke part is improved; the two effects promote each other, the stroke microenvironment is improved, the functions of neuronal cells are saved, the synergistic nerve protection effect can be achieved in the aspect of treating ischemic cerebral apoplexy, and potential safety hazards are reduced.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI

Composition with effects of resisting oxidation, brightening and delaying skin saccharification as well as preparation method and application of composition

PendingCN120570798ACosmetic preparationsToilet preparationsMirabilis jalapaPhospholipin
The invention relates to a composition with antioxidant and brightening effects and capable of delaying skin saccharification as well as a preparation method and application of the composition, and belongs to the field of cosmetics. The composition comprises an ormosia henryi bark extract, tetrahydrocurcumin, a mirabilis jalapa extracting solution, a surfactant, polyol, phospholipid and a solvent. The composition provided by the invention has good illumination stability and high-temperature stability, and the composition provided by the invention is high in bioavailability, and has good antioxidant and brightening effects and lipofuscin and RAGE level inhibition effects.
Owner:GUANGZHOU FANZHIRONG COSMETICS CO LTD +1

Preparation method of curcumin-loaded Pickering emulsion steady-state carrier and tea protein-chitosan composite nanoparticles used by same

The invention discloses a preparation method of a curcumin-loaded Pickering emulsion steady-state carrier and tea protein-chitosan composite nanoparticles used by the curcumin-loaded Pickering emulsion steady-state carrier, and belongs to the technical field of high-valued processing of food functional factors. The preparation method comprises the following steps: firstly, extracting tea protein from a tea leaf processing byproduct tea residue by adopting an alkali extraction and acid precipitation method, and secondly, constructing the tea protein-chitosan composite nanoparticles by adopting a pH induction method. And mixing the oil phase containing curcumin with the water phase, and emulsifying by using a high-speed shearing machine to prepare the Pickering emulsion. The method is simple to operate, the prepared Pickering emulsion stabilized by the tea protein-chitosan composite nanoparticles can improve the bioavailability of curcumin from 10.8% to 32.6%, meanwhile, high-value utilization of the tea protein is achieved, and the method has important significance in promoting development and application of functional food.
Owner:ANHUI AGRICULTURAL UNIVERSITY

Composite hydrogel for repairing infectious bone defects and preparation method thereof

The invention provides a composite hydrogel for infectious bone defect repair and a preparation method thereof, and belongs to the technical field of bone defect repair, the composite hydrogel comprises a three-dimensional porous network structure hydrogel and a bioactive unit, and the bioactive unit is loaded in the three-dimensional porous network structure hydrogel; the hydrogel with the three-dimensional porous network structure is prepared from photo-crosslinked methacrylated silk fibroin and nano-hydroxyapatite; the bioactive unit comprises a strontium metal organic framework loaded with curcumin. According to the invention, the photo-crosslinked methacrylated silk fibroin provides excellent biocompatibility; as an ion / drug dual carrier, the strontium metal organic framework can continuously release strontium ions and bidirectionally regulate bone metabolism (promoting osteogenesis and inhibiting osteoclast), and the porous structure of the strontium metal organic framework can efficiently load a hydrophobic drug curcumin (Cur). Curcumin has strong antibacterial and anti-inflammatory functions; the nano-hydroxyapatite can obviously enhance the mechanical strength of the hydrogel.
Owner:ASIA BIOMATERIALS WUHAN CO LTD

Green and environment-friendly subcritical water-assisted constructed plant double-protein-based dried meat floss and preparation method thereof

The invention discloses green and environment-friendly subcritical water-assisted constructed plant double-protein-based dried meat floss and a preparation method thereof, and belongs to the technical field of food. The preparation method of the plant dried meat floss comprises the following steps: modifying soybean drawing protein and bran protein by using subcritical water, mixing the modified double protein, seasoning auxiliary materials, color mixing auxiliary materials and curcumin according to a certain proportion, and performing high-temperature baking, floss wiping, floss picking, packaging and other processes on the mixed materials to obtain the dried meat floss. The plant dried meat floss has the characteristics of being crisp, fluffy, golden in color, fine and uniform in fiber, anti-inflammatory and the like, not only has unique flavor, texture and anti-inflammatory function, but also is green and environment-friendly in preparation process and low in raw material price, and provides a theoretical basis for developing novel green, economic and nutritional dried meat floss products.
Owner:YANGZHOU UNIV

Intelligent wound dressing with photo-thermal drug controlled release and motion sensing monitoring functions and preparation method thereof

The invention relates to the field of wound dressings and the field of flexible strain sensors, in particular to an intelligent wound dressing with drug controlled release and motion detection functions and a preparation method of the intelligent wound dressing. The wound dressing comprises thermoplastic polyurethane, liquid metal, lauric acid and curcumin, a TPU elastic material serves as a substrate, the liquid metal serves as a photo-thermal agent and a sensor flexible circuit part, the motion monitoring function can be achieved, and good biocompatibility is achieved; lauric acid is used as a thermal phase change material, curcumin is used as a bioactive drug, and photo-thermal response drug controlled release is achieved; the intelligent wound dressing with photo-thermal drug controlled release and motion monitoring functions is prepared by combining electrostatic spinning, electrostatic spraying and template printing technologies, and has a wide application prospect in the field of wound dressings.
Owner:GUANGDONG UNIV OF TECH

Production method of konjak series clearing and conditioning diet

The invention provides a production method of a konjak-series Qingqing diet, and belongs to the technical field of konjak-series Qingqing diet, and the production method comprises the following steps: forming a primary colloid through an accurately controlled hydration process, then introducing soybean and pea proteins, and carrying out thermal gelation treatment to construct a composite gel matrix; functional plant extracts such as curcumin, tea polyphenol and a grape seed extract are added, and the release efficiency of active ingredients is improved by adopting an ultrasonic-assisted extraction technology. The method further comprises the step of adding vitamin complex and calcium and magnesium trace elements, finally, high homogenization of the product is achieved through an innovative tree-shaped multi-cavity homogenization treatment mechanism, the mechanism adopts a minimum spanning tree algorithm to optimize a fluid transmission path, and the technical problem of efficient compounding of the konjak gel and the functional plant extract is successfully solved.
Owner:YUNNAN CUIYUYUNPIN BIOTECHNOLOGY CO LTD

Diglyceride-containing grease composition and preparation method thereof

The invention relates to the technical field of diglyceride oil, and discloses a diglyceride-containing grease composition and a preparation method thereof. According to the present invention, a variety of vegetable oils are combined, the combined vegetable oil is subjected to glycerol diesterification, and the turmeric is directly extracted by using the oil after the enzymolysis so as to integrally prepare the curcumin-containing diglyceride oil; according to the present invention, the mass content of diglyceride in the diglyceride oil prepared by combining a plurality of vegetable oils is 40-95%, the mass content of oryzanol is 10000-20000 ppm, the mass content of sterol is 8000-10000 ppm, and the mass content of curcumin is 0.1-0.2%, such that the diglyceride, the oryzanol, the sterol and the curcumin in the diglyceride oil are subjected to a specific content and proportion so as to prevent the color reversion of the oil composition, such that the color reversion of the oil composition can be prevented, and the oil composition can be easily obtained. The grease composition keeps bright appearance and has the advantage of being good in stability.
Owner:FASTCO BIOTECHNOLOGY (HANGZHOU) CO LTD