669 results about "Curcumin" patented technology

The invention relates to the technical field of pharmaceutical preparations, and discloses a composition with liver protection and antioxidation effects and a preparation method thereof.The composition is prepared from galactosamine modified astragalus membranaceus exosome, schisandra chinensis nanocrystals, liquorice-chitosan nanoparticles, lactobacillus acidophilus freeze-dried powder, beta-(1, 3) / (1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate) sourced from saccharomyces cerevisiae, and beta-(1, 3, 4-tetramethyl-1, 3-pentanediol monoisobutyrate). And (6) a dextran, grape exosome-curcumin hybrid vesicle freeze-dried powder, a curcumin-mitochondrial targeting peptide compound, a resveratrol-hydroxypropyl-beta-cyclodextrin inclusion compound and reduced panthenol. According to the liver-protecting and anti-oxidation composition disclosed by the invention, multi-dimensional intervention on liver protection is realized through an elaborately designed ternary system. The system is composed of a traditional Chinese medicine extract, a microorganism-plant exosome combination and a high-bioavailability antioxidant, all the parts have a synergistic effect, and the liver protection effect is remarkably improved.

The invention discloses a Janus wound dressing with antibacterial and tissue repair promoting functions and a preparation method of the Janus wound dressing, belongs to the technical field of wound dressings, and aims to realize antibacterial, tissue repair promoting and moist wound healing microenvironment through freeze drying and electrostatic spinning technologies. Polycaprolactone (PCL), bioactive glass (BG) and curcumin Cur are used for preparing a hydrophobic inner layer capable of promoting tissue repair, methacrylated gelatin GelMA is used for preparing a hydrophilic outer layer with moisturizing performance, and the PCL-BG-Cur / GelMA composite wound dressing with antibacterial, moisturizing and repair promoting functions is constructed. Animal experiment results show that the dressing loaded with curcumin Cur and bioactive glass BG has multiple functions of synergistic antibiosis, moisturizing and the like, the result shows that the prepared dressing has the performance of promoting epithelization, collagen deposition, new hair follicle formation and the like, and the dressing has a considerable application prospect in the aspect of rapid wound repair.

The invention relates to curcumin-loaded pectin sodium alginate gel as well as a preparation method and application thereof, and belongs to the technical field of gel preparation. The preparation method of the curcumin-loaded pectin sodium alginate gel comprises the following steps: in a dark environment, stirring and mixing curcumin, arjunic acid, ortho-aminophenol and an organic solvent, adding a polyvinyl alcohol aqueous solution, a sodium alginate solution and a pectin solution, uniformly mixing, performing ultrasonic treatment, adding calcium chloride, stirring and mixing, performing ultrasonic treatment, and performing vacuum drying to obtain the curcumin-loaded pectin sodium alginate gel. And adding oxidized hyaluronic acid, continuously stirring, stirring at normal temperature until the organic solvent is completely volatilized, and cleaning the hydrogel with deionized water to obtain the hydrogel. According to the invention, calcium ions and sodium alginate are subjected to physical crosslinking, pectin and polyvinyl alcohol are combined to form a composite hydrogel layer, the compounding of multiple components can effectively control the dissolution and drug release behaviors of active components, the bioavailability of curcumin is increased, the compactness and stability of hydrogel are increased, and the bioavailability of curcumin is improved. The oxidation resistance of the hydrogel can be effectively improved.

The invention belongs to the technical field of functional Pickering emulsion preparation, and particularly discloses a silk fibroin nanoparticle-stabilized biphase drug-loaded Pickering emulsion and an antibacterial application thereof. The curcumin-loaded silk fibroin nanoparticles Cur-SFNPs with uniform form and size are prepared by using an anti-solvent precipitation method. In order to improve the antibacterial effect of the Pickering emulsion, the Cur-SFNPs is utilized to stabilize the soybean oil loaded with resveratrol, and the oil-in-water type Pickering emulsion is prepared. The Pickering emulsion prepared by taking Cur-SFNPs as a stabilizer has the characteristics of small particle size, uniform distribution, storage stability, heating stability, freeze-thaw stability, food safety and environmental friendliness. And as a two-phase drug-loaded emulsion, two natural hydrophobic active drugs are loaded at the same time, so that the solubility and bioavailability of the emulsion can be enhanced, the loaded active substances play a synergistic antibacterial and antioxidant role, and the emulsion can be applied to food preservation.

The invention belongs to the technical field of food processing, and particularly relates to a curcumin-loaded protein-polysaccharide nanoparticle delivery system, a preparation method thereof and application of the curcumin-loaded protein-polysaccharide nanoparticle delivery system in neuroprotection. The preparation method comprises the following steps: mixing and dissolving sodium caseinate with one of glucan and pectin, hydrating at 0-4 DEG C for 12-24 hours, and performing ultrasonic and microwave treatment to obtain a pretreatment solution; adjusting the pH value, and heating the pretreatment solution to obtain covalent grafted particles; the protein-polysaccharide covalent grafted particles obtained in the second step are encapsulated with curcumin through a pH shift method, and the protein-polysaccharide-curcumin nanoparticles are obtained. The invention provides a method for carrying out Maillard reaction on sodium caseinate-polysaccharide under the assistance of ultrasound and microwaves, reaction parameters are optimized, and a preparation method of an efficient and stable curcumin delivery system and application of the curcumin delivery system in neuroprotection are constructed.

The invention relates to the technical field of food fresh-keeping materials, in particular to a chitosan-curcumin nano-composite fresh-keeping agent and a preparation method thereof.The chitosan-curcumin nano-composite fresh-keeping agent comprises nano-particles of a chitosan-sodium alginate-oxidized sodium alginate interpenetrating network structure, according to the nanoparticles, protonated amino groups of chitosan and carboxyl groups of sodium alginate form a polyelectrolyte compound core, aldehyde groups of oxidized sodium alginate and amino groups of chitosan are subjected to a Schiff base reaction to form a chemical cross-linked network, and zinc ions, amino groups of chitosan, carboxyl groups of sodium alginate and carboxyl groups of oxidized sodium alginate form coordination cross-linking; curcumin and epigallocatechin gallate form a compound through a hydrogen bond and a hydrophobic effect, the compound is embedded in an interpenetrating network structure, beta-diketone groups of curcumin and zinc ions form chelating coordination, a chitosan-sodium alginate-oxidized sodium alginate ternary interpenetrating network is constructed, and the chitosan-sodium alginate-oxidized sodium alginate ternary interpenetrating network structure is formed. The stability is improved by utilizing the synergistic effect of triple mechanisms of electrostatic interaction, Schiff base chemical bonds and zinc ion coordination.

The invention relates to a composition with antioxidant and brightening effects and capable of delaying skin saccharification as well as a preparation method and application of the composition, and belongs to the field of cosmetics. The composition comprises an ormosia henryi bark extract, tetrahydrocurcumin, a mirabilis jalapa extracting solution, a surfactant, polyol, phospholipid and a solvent. The composition provided by the invention has good illumination stability and high-temperature stability, and the composition provided by the invention is high in bioavailability, and has good antioxidant and brightening effects and lipofuscin and RAGE level inhibition effects.

The invention discloses a preparation method of a curcumin-loaded Pickering emulsion steady-state carrier and tea protein-chitosan composite nanoparticles used by the curcumin-loaded Pickering emulsion steady-state carrier, and belongs to the technical field of high-valued processing of food functional factors. The preparation method comprises the following steps: firstly, extracting tea protein from a tea leaf processing byproduct tea residue by adopting an alkali extraction and acid precipitation method, and secondly, constructing the tea protein-chitosan composite nanoparticles by adopting a pH induction method. And mixing the oil phase containing curcumin with the water phase, and emulsifying by using a high-speed shearing machine to prepare the Pickering emulsion. The method is simple to operate, the prepared Pickering emulsion stabilized by the tea protein-chitosan composite nanoparticles can improve the bioavailability of curcumin from 10.8% to 32.6%, meanwhile, high-value utilization of the tea protein is achieved, and the method has important significance in promoting development and application of functional food.

The invention provides a composite hydrogel for infectious bone defect repair and a preparation method thereof, and belongs to the technical field of bone defect repair, the composite hydrogel comprises a three-dimensional porous network structure hydrogel and a bioactive unit, and the bioactive unit is loaded in the three-dimensional porous network structure hydrogel; the hydrogel with the three-dimensional porous network structure is prepared from photo-crosslinked methacrylated silk fibroin and nano-hydroxyapatite; the bioactive unit comprises a strontium metal organic framework loaded with curcumin. According to the invention, the photo-crosslinked methacrylated silk fibroin provides excellent biocompatibility; as an ion / drug dual carrier, the strontium metal organic framework can continuously release strontium ions and bidirectionally regulate bone metabolism (promoting osteogenesis and inhibiting osteoclast), and the porous structure of the strontium metal organic framework can efficiently load a hydrophobic drug curcumin (Cur). Curcumin has strong antibacterial and anti-inflammatory functions; the nano-hydroxyapatite can obviously enhance the mechanical strength of the hydrogel.

The invention discloses a method for producing feed by using corn sugar residues, and belongs to the technical field of fermentation. The method comprises the following steps: pretreating, proportioning, adding an antibacterial agent, fermenting, drying and crushing, coating, cooling and the like, mixing corn sugar residues, corn germ meal and threonine mother liquor according to a specific ratio, adding zinc oxide and a chitosan antibacterial agent, and inoculating Saccharomyces cerevisiae ATCC 9763 for fermenting. And performing multi-stage drying and crushing on the fermentation product, spraying a coating emulsion prepared from a defatted soybean meal extract, curcumin, vitamin E, lecithin and sophorolipid, and performing air cooling to prepare the feed. According to the method, by-products are fully utilized, the crude protein content of the feed is 32-34.5%, the diameter of an inhibition zone is 18.1-20.2 mm, the moisture absorption rate is 2.7-3.4%, the palatability score is 8.0-8.6, and the fermentation yield is 92-94%. The innovation point lies in specific strain fermentation and functional coating, and is suitable for industrial production.

The invention relates to the technical field of textile fabrics, in particular to an antibacterial composite fabric and a preparation process thereof. Comprising the following steps: S1, treating a fabric for 30 minutes at 100 DEG C by using a NaOH aqueous solution according to a bath ratio of 1: 50, washing the fabric with deionized water, and drying the fabric at 80 DEG C; soaking the fabric in the finishing agent according to a bath ratio of 1: 40, soaking at 40 DEG C for 24 hours, washing with deionized water, and drying at 80 DEG C; s2, 50 g of the fabric obtained in the step S1 is soaked in 150 mL of a curcumin-coated UiO-66-NH2 compound aqueous solution, and soaking is conducted for 24 h at the temperature of 30 DEG C; and then drying to obtain the antibacterial composite fabric. Through low-temperature finishing of natural curcumin-UiO-66-NH2-MOF, the cotton fabric can obtain the antibacterial rate of more than or equal to 96% of escherichia coli and more than or equal to 98% of staphylococcus aureus within the active component range of 20-80 g / L, and the antibacterial retention rate is still more than or equal to 80% after 50 times of industrial washing; the process is mild and does not damage cotton fibers.

The invention discloses a probiotic animal feed and a preparation method thereof, and belongs to the technical field of animal feeds, the probiotic animal feed comprises the following components by mass: 40-55 parts of caragana microphylla powder, 20-30 parts of fermented soybean meal, 3-5 parts of a composite probiotic preparation, 5-10 parts of a medicinal and edible additive, and 2-3 parts of a mineral premix. According to the composite probiotic preparation, bacillus licheniformis, pediococcus pentosaceus and saccharomyces cerevisiae boulardii synergistically improve the fiber decomposition efficiency, inhibit pathogenic bacteria and reduce ammonia nitrogen emission. The medicinal and edible additive is of a multi-layer micro-capsule structure, the outer layer is carboxymethyl chitosan and copper gluconate modified nano zeolite, active substances in the middle layer are rapidly released through rumen pH response, and the middle layer contains a yucca extract, a liquorice extract and other components and can inhibit urease activity and ammonia-producing bacteria; in the inner layer, a nano-selenium-vitamin E compound, curcumin and the like are slowly released through sodium alginate-pectin gel, so that intestinal metabolism is optimized. The process of pretreating caragana microphylla through steam explosion and performing solid-state fermentation on soybean meal through aspergillus oryzae is utilized, so that grain-free production is realized.

The invention relates to the technical field of food sustained-release preparations, and particularly discloses a sour cherry powder sustained-release preparation with a stable uric acid reducing effect and a preparation process of the sour cherry powder sustained-release preparation. The sour cherry powder sustained-release preparation comprises a core active phase freeze-dried sour cherry powder, a sustained-release carrier phase, a synergistic function phase, an auxiliary regulation phase and a filler, the synergistic functional phase contains a celery seed extract, a curcumin-phospholipid complex, a prebiotic complex and the like, and all the components have a synergistic effect. The preparation method comprises the following steps: carrying out wall breaking, enzymolysis, purification and freeze-drying treatment on sour cherry fruits to obtain a core raw material, compounding the core raw material with other components, and carrying out slow-release carrier construction, coating granulation and other steps to prepare the microcapsule structure preparation. The preparation can be used for assisting in reducing the uric acid level, and has the advantages of high stability of active ingredients, continuous and stable uric acid reducing effect, consideration to intestinal health and the like; the preparation process adopts freeze-drying and micro-capsule coating technologies, effectively retains active ingredients, is controllable in operation, and is suitable for large-scale production.

The invention relates to a composition for treating large yellow croaker pyramidoniasis as well as a preparation method and application thereof, and belongs to the technical field of aquaculture. The composition comprises the following components: curcumin, bile acid, beta glucan, bacillus subtilis freeze-dried powder, marine red yeast freeze-dried powder, vitamin C, vitamin E and ethylicin. When the feed additive is added into basal feed to feed large yellow croakers infected with the trypanosomiasis, the death rate of sick fishes can be effectively reduced, the polypide loading capacity is remarkably reduced, and pathological injuries of livers and spleens of the large yellow croakers are relieved. In addition, the composition can also improve the non-specific immunity of the fish body, improve the liver function, enhance the antioxidant capacity of the liver, and improve the lipase activity of the intestinal tract at the same time. Therefore, the composition can be used as a medicine or a feed additive for treating the large yellow croaker pyramidoniasis, has the advantages of small dosage and remarkable effect, and provides a new technical approach for solving the problem that the current large yellow croaker pyramidoniasis lacks an effective prevention and control means.

The invention discloses injectable hydrogel for alveolar bone repair, the injectable hydrogel comprises a first component and a second component, the first component comprises 4-carboxyl-3-fluorophenylboronic acid modified carboxymethyl chitosan CMCS-FPBA and beta-tricalcium phosphate, and the second component comprises oxidized dextran, PPS-HA nano-micelle and curcumin. The invention also discloses a preparation method and application of the injectable hydrogel. The injectable hydrogel disclosed by the invention has the effects of resisting oxidation, resisting inflammation and promoting bone tissue regeneration, is high in biocompatibility, can be customized in a personalized manner, and can be used for repairing alveolar bones.

The invention relates to the technical field of nano composite materials, in particular to a nano composite containing fat-soluble functional factors as well as a preparation method and application of the nano composite. Debranched starch is subjected to etherification modification, so that the hydrophilicity of the starch is increased, and negative charges are given to the starch; according to the nano-composite material, the nano-composite material is used as a nano-material, then the nano-composite material and alcohol-soluble protein (Zein) are used for composite embedding of curcumin, astaxanthin and other fat-soluble functional factors based on electrostatic, hydrophobic and hydrogen bond interaction, a uniform and regular nano-composite is formed, and the composite is relatively high in pH, ionic strength and thermal stability, small in particle size and relatively high in embedding rate and loading capacity for curcumin, astaxanthin and other fat-soluble functional factors. In addition, a continuous preparation process is adopted, so that the intermediate step of freeze drying and redissolving is avoided, and the process flow is greatly simplified.

This invention is directed to compositions comprising curcumin extract and pomegranate extract, and methods of improving immune response with the compositions. The compositions may be administered as a prebiotic and / or a dietary supplement.

The invention discloses a gelatin bacterial cellulose composite material with a lotus leaf structure as well as a preparation method and application thereof, and belongs to the technical field of packaging and fresh keeping. The preparation method comprises the following steps: accurately copying a micro-nano structure on the surface of the lotus leaf by utilizing a polydimethylsiloxane template technology, mixing a gelatin solution, a bacterial cellulose solution, glycerol and a functional active substance curcumin to obtain a film forming solution, drying the film forming solution on a template to form a film, and then removing the template. The surface of the material naturally presents a lotus leaf bionic structure, and the material is endowed with excellent hydrophobic performance without additional chemical modification or hydrophobic coating. The method is simple and convenient in process, healthy and harmless, and the prepared functional composite film integrates hydrophobicity, antibacterial property, oxidation resistance, ultraviolet shielding property and good mechanical property, is suitable for the packaging and fresh-keeping fields of food, medicines, agricultural products and the like, can effectively prolong the shelf life, and meets the development requirements of green packaging.

The invention discloses a targeted slow-release curcumin compound with an auxiliary liver protection function and a preparation method thereof.The preparation method comprises the steps that whey protein isolate is heated under the acidic condition to prepare whey protein isolate fibers, and then the whey protein isolate fibers are compounded with kappa-carrageenan; adjusting the mixed system to be alkaline by adopting a pH migration method, adding a curcumin alkaline solution, fully dissolving the curcumin alkaline solution, and combining the curcumin alkaline solution with the whey protein isolate fiber-kappa-carrageenan composite system; and adjusting the pH value of the system back to be neutral to obtain the high-load amorphous curcumin solution and the solid preparation. The whey fiber and the kappa-carrageenan are self-assembled in the pH circulation process to form a composite carrier, curcumin is converted into an amorphous state from a crystalline state, the solubility of curcumin is remarkably improved, the loading capacity is greatly improved to 70% at most, the heat stability, oxidation resistance and biological accessibility of curcumin are improved, targeted slow release of curcumin can be achieved, and the curcumin-targeted slow release preparation has a good application prospect. The positioning release performance of the curcumin in the intestinal tract part is improved, and the application form of the curcumin in liver protection function products is expanded.

A curcumin-containing nano-drug for treating cancer, a preparation method therefor, and use thereof. The nano-drug comprises curcumin and an extracellular vesicle expressing an anti-cancer protein TRAIL, or the nano-drug comprises curcumin and a tumor-antigen binding polypeptide-modified extracellular vesicle expressing an anti-cancer protein TRAIL. The curcumin is loaded into the extracellular vesicle for combined use, such that an extremely strong synergistic effect can be generated; the anti-cancer activity of the EV-T can be significantly enhanced by means of polypeptide modification; the composite nano-drug obtained by loading the curcumin into the extracellular vesicle can solve the problem of insolubility of curcumin, thereby further improving the anti-cancer effect.

The invention discloses a preparation method of a liver protection medicine composition containing dihydromyricetin, and relates to the technical field of medicine preparation.According to the method, dihydromyricetin, puerarin, pueraria flower extract, corn oligopeptide, pyrroloquinoline quinone disodium salt, curcumin and ganoderan are used as raw materials; dihydromyricetin and puerarin are stirred, homogenized and dried in a mixed solvent to prepare the liver protection medicine composition, wherein the mass ratio of dihydromyricetin to puerarin is 1: (0.5-2). A multi-target liver protection system is constructed through cooperation of multiple components, the problems that a traditional liver protection medicine is poor in component solubility, easy to degrade in activity and weak in synergistic effect are solved, the bioavailability and stability of the product are improved, the process is simple and controllable, the preparation method is suitable for industrial production and can be prepared into oral preparations such as tablets and oral liquid, and the preparation method is suitable for industrial production. The composition is suitable for protection of alcoholic and chemical liver injury.

The invention provides a feed premix for improving chicken quality. The fresh-keeping agent is prepared from the following components in percentage by weight: 5%-15% of a flavor enhancing component, 10%-25% of a tenderness improving component, 3%-10% of an antioxidant fresh-keeping component, 2%-3% of a function enhancing component and the balance of a carrier and a diluent, the function strengthening component is prepared from beta-alanine embedded citronella essential oil and konjac glucomannan zymolyte; the flavor enhancing component comprises a rosemary extract, a yeast culture and curcumin in a mass ratio of (2-4): (1-3): 1; the tenderness improving component comprises conjugated linoleic acid, L-carnitine modified by glutamine transaminase and betaine in a mass ratio of (3-5): (2-4): 1; the antioxidant fresh-keeping component is vitamin E and tea polyphenol in a mass ratio of (1-2): 1. Through multi-component synergism and functional targeting optimization, a three-dimensional quality improvement system with enhanced flavor, improved tenderness, oxidation resistance and fresh keeping is constructed, so that the chicken quality is comprehensively upgraded.

This invention discloses a pH-sensitive curcumin nanoliposome, its preparation method, and its applications. The preparation method includes the following steps: dissolving 1,2-dioleoyl-SN-glycerol-3-phosphoethanolamine, cholesterol succinate monoester, cholesterol, pH-sensitive material, and curcumin in an alcohol solvent to obtain an inner-phase alcohol solution; dissolving a lyophilization protectant in water to obtain an outer-phase aqueous solution; the inner-phase alcohol solution is compressed by the outer-phase aqueous solution to form a laminar flow and diffuses into the aqueous phase to form a narrow mixed solvent region. When the ethanol content in the mixed solvent region is lower than the ethanol content required for the original substances to dissolve in the ethanol phase, the lipids will self-assemble to form liposomes. The liposomes prepared by this invention have a spherical morphology, controllable size, and sustained-release properties in vitro, showing good application prospects as anti-tumor drug carriers in the field of drug delivery.

The present invention relates to a microneedle-based transdermal delivery patch fabricated from a hydrogel composed of polyvinyl alcohol (PVA), arginine-modified chitosan, and a crosslinker. The arginine-modified chitosan is prepared by reacting a chitosan solution with an arginine solution preactivated with N-hydroxy succinimide and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide at a specific pH. The hydrogel's formulation further comprises a PVA concentration ranging from 10% to 12% (w / v). arginine-modified chitosan and PVA solution are mixed in a 1:2 ratio by volume and are crosslinked using trimethyl orthoformate (TMOF). The patch is further loaded with curcumin, with a concentration of 120μg per patch, demonstrating a 70% release over 48 hours in a controlled manner. This invention represents the first application of PVA crosslinked arginine-modified chitosan hydrogel loaded with curcumin specifically for animal wound healing, providing enhanced wound healing and antibacterial efficacy.

The invention discloses a core-shell nano-enzyme composite spray gel dressing and a preparation method and application thereof.The dressing comprises a component A prepared from sodium alginate, N-isopropylacrylamide PNIPAM, core-shell nano-enzyme and curcumin and a component B of a divalent metal salt solution, and the component A and the component B are sprayed at the same time to form the core-shell nano-enzyme composite spray gel dressing. The preparation method of the core-shell nano enzyme comprises the following steps: mixing potassium ferrocyanide, ferric trichloride and polyvinylpyrrolidone to obtain a Prussian blue nano particle precursor solution; carrying out ultrasonic emulsification treatment and replacement on the curcumin core solution and the Prussian blue nanoparticle precursor solution; and freeze-drying to obtain the core-shell nano-enzyme. Through rapid ionic crosslinking of sodium alginate and divalent metal ions and the temperature-sensitive phase change characteristic of the temperature-sensitive polymer poly (N-isopropylacrylamide), the gel dressing is rapidly formed, the damaged skin is effectively covered and protected, the excellent antioxidant, anti-inflammatory and antibacterial capabilities are achieved, and the healing cycle of the radiodermatitis wound can be remarkably shortened.

The invention relates to a turmeric enzyme beverage and a preparation method thereof, and belongs to the field of fermented beverages. The turmeric enzyme beverage is prepared from the following raw materials: curcumin, blueberries, mulberries, apples, radix polygonati officinalis and herba elsholtziae. According to the invention, blueberries, mulberries and apples are adopted to provide excellent nutrition, taste and flavor for the enzyme beverage, and the enzyme beverage also has a certain health-care effect; the curcumin, the polygonatum odoratum and the elsholtzia chinensis can remarkably improve the immunity of a human body; the enzyme beverage prepared by the preparation method disclosed by the invention is excellent in effect and has a relatively good application prospect.

The invention relates to the technical field of biology, in particular to saffron petal polysaccharide loaded curcumin gel beads as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing stigma croci petals and water, heating in a water bath, refluxing, filtering, extracting, carrying out rotary evaporation and concentration, taking supernate, adding absolute ethyl alcohol, standing, precipitating, carrying out centrifugal suction filtration, collecting polysaccharide, adding water for redissolving, carrying out rotary evaporation to remove ethyl alcohol, and freeze-drying for later use; uniformly mixing the freeze-dried saffron petal polysaccharide solution with a curcumin solution to obtain a petal polysaccharide-curcumin solution; sequentially adding sodium alginate and a calcium lactate solution into the petal polysaccharide-curcumin, uniformly mixing, and cross-linking to obtain the negative petal polysaccharide-curcumin composite gel beads. The curcumin is loaded by the sodium alginate, calcium lactate and crocus sativus petal polysaccharide composite material, so that the hardness and the structural stability of the gel beads are enhanced, the encapsulation efficiency of the curcumin is improved, targeted slow release is favorably realized, and a practical scheme is provided for efficient delivery of natural active ingredients.

Methods of making bioactive compound-loaded nanoparticles are provided. The methods harness naturally-occurring biopolymers to produce nanoparticles from raw plant materials. Methods include contacting plant-derived materials with alkaline solution with agitation to deprotonate the bioactive materials and biopolymers to form nanoparticles. In some forms, the methods contact the nanoparticle with an acid to re-protonate the components and more stable nanoparticles. The bioactive compounds can be extracted from raw plants and / or plant parts, including turmeric, ginger, clove, thyme, pepper, and rosemary. The bioactive compounds include curcumin, gingerols, shogaols, eugenol, thymol, carvacrol, capsaicin, and rosmarinic acid. Compositions and formulations containing bioactive-compound loaded nanoparticles are also provided.

The invention provides a natural Chinese herbal medicine hydrogel composite microneedle and a preparation method and application thereof.The preparation method comprises the steps that S1, natural food-borne nutrients and glycyrrhizic acid are mixed in a solvent, and a glycyrrhizic acid / natural food-borne nutrient solution is obtained; the natural food-borne nutrient is one or more of astaxanthin, baicalein, berberine and curcumin; s2, dropwise adding a metal salt solution into the glycyrrhizic acid / natural food-borne nutrient solution, and performing ultrasonic treatment and stirring to obtain glycyrrhizic acid / food-borne active substance gel; s3, mixing the polyanionic polymer solution with the glycyrrhizic acid / food-borne active substance gel to obtain a mixed solution; and S4, adding the mixed solution into a microneedle mold, carrying out vacuum centrifugation, and drying to obtain the microneedle patch. Good biocompatibility of the natural Chinese herbal medicine extract glycyrrhizic acid is used as a carrier to increase the in-vivo utilization rate of natural food-borne nutrients, so that a better treatment effect is achieved.

The invention relates to the technical field of biomedical materials, in particular to a multifunctional oil gel wound dressing and a preparation method thereof. The raw material of the multifunctional oleogel wound dressing comprises oleogel; the preparation method of the oleogel comprises the following steps: preheating oil, adding anti-solvent beta-sitosterol and candelilla wax, and uniformly mixing to obtain a mixture; and adding curcumin into the mixture, uniformly mixing, and cooling to obtain the oleogel. The anti-solvent beta-sitosterol and candelilla wax are utilized to prepare the curcumin lipid carrier (mixture) with good stability and smearing property, and the stability of curcumin is improved. The prepared oleogel has the capability of promoting healing of chronic wounds of diabetes mellitus.