730 results about "Pancreas" patented technology

The present invention provides methods of treating a cancer patient with an inhibitor of KRAS and an anti-CCR8 antibody. These methods are useful for treating a number of cancers, including pancreatic, colorectal, and lung cancers.

Systems and methods for cooling a biological sample with different temperature cooling blocks. Warmer cooling blocks can be placed around a container and cooler cooling blocks can be placed above the container. The biological sample can be a pancreas, heart or other organs. The method and system can rely on convection, or gravity-based fluid movement, to make the temperature within the container consistent.

The invention discloses a human pancreas islet function digital evaluation method and system based on an AI algorithm, and relates to the technical field of artificial intelligence medical evaluation, and the method comprises the steps: collecting and preprocessing multi-modal physiological data; extracting multi-source features to generate a low-dimensional input vector; performing dynamic weighted fusion based on a space-time attention mechanism; constructing a neural differential equation model in which a beta cell two-phase secretion mechanism is introduced, and outputting pancreas islet function evaluation indexes; and a dynamic evaluation report is generated through a visualization and early warning module. According to the method, the modeling accuracy of the pancreas islet function under the interference of complex behaviors can be improved, the individualized quantitative evaluation of function decline trend prediction and sensitivity scoring is realized, the clinical staging reference value and the model interpretation ability are enhanced, and the technical problems of low fusion precision, poor dynamic nature and lack of physiological constraints in the existing method are solved.

Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

The invention relates to a reconstruction method of a liver, gall and pancreas three-dimensional image. According to the technical scheme, the method comprises the following steps: introducing a segmentation network for U-Net variants of the liver, the bile duct and the pancreas, and segmenting a multi-modal image by using a convolutional neural network, including separation of the liver, the bile duct and the pancreas; a boundary enhancement module is introduced in the segmentation process; performing spatial alignment on the image data of different modalities by adopting a deep learning driven non-rigid registration algorithm; carrying out registration by utilizing anatomical feature points of the organs; according to a registration result, performing multi-modal fusion on the liver image, the bile image and the pancreas image, and constructing fusion image data by comprehensively utilizing the bone and tissue contrast ratio of CT, the soft tissue resolution ratio of MRI and the real-time dynamic characteristics of ultrasound; extracting contours of liver, gall and pancreas from the segmented image, and constructing a preliminary three-dimensional mesh model; and according to the geometrical shapes of different organs, adaptive adjustment is carried out, and the distribution of grids during reconstruction is controlled to be matched with the organ shapes.

The invention, which relates to the technical field of nursing management, discloses a patient information safety management system for liver, gall and pancreatic internal medicine nursing, comprising a nursing information management center. The nursing information management center is in communication connection with a patient information collection module, an information classification processing module, a health trend analysis module, a risk assessment analysis module, a risk early warning planning module and an information synchronous updating module. According to the patient information safety management system for nursing in the department of hepatobiliary and pancreatic, through implementation of the patient information safety management system, medical staff can access latest and most accurate patient data in real time, and a risk assessment analysis module comprehensively analyzes the medical history, the current illness state and the treatment progress of a patient and calculates a risk assessment coefficient; in addition, by updating the medical information of the patient in real time, making and executing a personalized nursing plan, the change of the illness state of the patient is quickly responded, and the nursing and treatment scheme is adjusted in time.

The invention relates to the technical field of radiotherapy, in particular to a space-time compensation method and system for radiotherapy of pancreas respiratory movement variability, and the method comprises the steps: setting an infrared reflective mark point on the body surface of a patient, and obtaining a body surface three-dimensional CT image and an infrared camera real-time image under respiratory movement; establishing a pancreas three-dimensional model, a CTV target region model and a respiratory movement model; predicting body surface mark point displacement by adopting a long-short-term memory network algorithm and generating a respiration curve; determining a pancreas three-dimensional coordinate motion state; predicting lung motion by using optical flow motion estimation, and reversely solving a pancreas motion trail; determining the opening and closing states of the blades of the multi-blade collimator; according to the method, the mapping relation between lung movement and pancreatic movement is established through reverse mapping, an improved optical flow movement estimation algorithm and an LSTM network are adopted to predict respiratory movement, and the CTV leakage volume can be remarkably reduced to 0.4 cm from 2.1 cm of a traditional gating technology.

The invention provides a traditional Chinese medicine composition and an application thereof in preparing a product for preventing, alleviating or treating acute hepatopancreatic necrosis of shrimp, belonging to the field of veterinary medicine. The active ingredients of the traditional Chinese medicine composition include isatis root, artificial bezoar, liquorice, borneol, pig gall powder and xuanming powder. The traditional Chinese medicine composition has a good therapeutic effect on preventing, alleviating or treating acute hepatopancreatic necrosis of shrimp, with a cure rate of more than 70%, has antibacterial and liver-protecting effects, can effectively improve the degree of liver damage, improve the survival rate of shrimp and reduce losses.

A three-dimensional scaffold for use in engineered tissue includes a repeated 3D geometry; and at least one of a hydrogel, a biocompatible polymer, and a bioprintable polymer. The repeated 3D geometry may include an open geometry including a plurality of interconnected nodes configured to be seeded with living cells. The scaffold may be formed via bioprinting. The three-dimensional scaffold may also be used for (1) 3D tissue modelling (for liver, kidney, gut, pancreas, heart, lung, spleen, etc.), (2) disease modeling of different tumor types such as breast, colorectal, lung, liver, brain, ovarian and others, (3) drug testing / therapeutic screening of small molecule drugs, peptides, proteins, antibodies, ADCs, gene therapies, RNA-based therapeutics, cell therapies, and tissue therapies, and (4) therapeutic / drug delivery (i.e., via delivery device that can be used to control drug release based on different patterns).

The invention discloses a CNN-Transform method based on multi-scale feature interaction, and mainly relates to the technical field of medical image analysis. Comprising the following steps: S1, acquiring sufficient amount of pancreas and tumor CT data, labeling the data, defining an ROI (Region of Interest), and distributing corresponding labels; s2, dividing the data set obtained in the step S1 into a training set and a test set, and preprocessing the training set and the test set by a data enhancement method including random rotation, scaling and mirroring; and S3, a CNN-Transform pancreas and tumor segmentation model PanUNet based on multi-scale feature interaction is constructed. Visual and accurate image information can be provided for doctors through accurate pancreas and tumor segmentation, personalized treatment schemes can be formulated in time, and the survival rate of patients is increased.

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

The invention belongs to the technical field of image segmentation, and relates to a semi-supervised pancreatic image segmentation method based on prototype estimation and prototype consistency. According to the method, based on a semi-supervised segmentation framework of an average teacher, V-Net is adopted as a deep learning segmentation model, and a projection head is inserted in the last but one stage of a decoder as a prototype branch; prototype learning design prototype estimation is introduced, unmarked data prediction is divided into determined areas of fuzzy areas, and different losses are designed for areas with different reliability of the unmarked data. The problems that in an existing semi-supervised learning segmentation method, unmarked data cannot be fully utilized, potential information of marked data is insufficient in utilization and the like are effectively solved, and a higher-performance solution is provided for an abdominal CT image pancreatic organ segmentation task.

The invention discloses a radionuclide labeled molecular probe for detecting collagen structure denaturation and a preparation method and application thereof, and relates to the technical field of biology. The structural general formula of the radionuclide labeled molecular probe disclosed by the invention is as follows: K (chelating agent-nuclide)-K-Linker-CHP, wherein K (chelating agent-nuclide) is a lysine residue labeled by a side chain amino coupling chelating agent and a radionuclide; the Linker is a connection joint; cHP is a collagen hybrid peptide with a polypeptide sequence of (GfO) n or (GPO) n. The probe has excellent definition and signal-to-noise ratio, not only can detect pancreatic ductal adenocarcinoma in a pancreatic cancer model, but also can sensitively detect precancerous lesions (such as pancreatic intraepithelial neoplasia lesions) of the pancreatic ductal adenocarcinoma and pulmonary fibrosis lesions in a bleomycin pulmonary fibrosis model. And the kit has important significance on early detection of pancreatic duct adenocarcinoma and reflection of dynamic change of ECM remodeling.

The invention provides a gamma delta T cell preparation as well as a preparation method and application thereof, and belongs to the technical field of T cells. The liposome is prepared from the following raw materials in parts by weight: 15-20 parts of modified gamma delta T cell liposome, 1-3 parts of cell stimulating factors and 4-7 parts of culture medium freeze-dried powder, the modified gamma delta T cell lipidosome is prepared by embedding gamma delta T cells through lipidosome, coupling with acetylenic bond modified chitosan, and further mixing with MFAP4 protein and b4GALT1 protein. The culture medium freeze-dried powder is prepared by freeze-drying the culture medium in the engineering culture process of gamma delta T cells, and the cell stimulating factors are resveratrol and quercitrin. According to the gamma delta T cell preparation prepared by the invention, the survival ability and resistance of gamma delta T cells are improved, the anti-tumor activity of the gamma delta T cells is improved, and the gamma delta T cell preparation has relatively good antioxidant and anti-inflammatory effects, reduces the inhibition of inflammation on an immune system and has a very good treatment effect on pancreatic ductal adenocarcinoma.

The invention discloses a liver, gall and pancreas clinical puncture sampling device in the technical field of medical instruments, which comprises a base, a mechanical arm is fixedly connected to the base, a puncture needle is arranged at the top end of the mechanical arm, a guide rail for mounting the puncture needle is fixedly connected to the top end of the mechanical arm, a pushing part is slidably matched with one side of the guide rail, and the puncture needle is fixedly connected with the pushing part. The base is further fixedly connected with a pump assembly and a fixed arm, the top end of the fixed arm is fixedly connected with a multi-mode integrated sensor, and the side wall of the fixed arm is fixedly connected with a controller. By integrating a plurality of functional layers, the puncture needle can achieve a plurality of functions in single puncture, the mechanical arm is controlled to guide the puncture process of the puncture needle and compensate respiratory movement displacement through model construction and displacement prediction of the controller, and bleeding stopping gel is sprayed in a self-adaptive mode through resistance borne during needle insertion, so that massive bleeding is avoided; therefore, the efficiency of the hepatobiliary pancreas puncture operation is improved, the possibility of tissue bleeding infection is reduced, and the painless treatment experience of a patient is improved.

The invention relates to the technical field of medical instruments, in particular to an electromagnetic focusing extracorporeal shock wave pancreatic lithotripsy device and method.The electromagnetic focusing extracorporeal shock wave pancreatic lithotripsy device comprises a device body, a bed body is installed on one side of the device body through a supporting frame, and a lithotripsy notch is formed in the side, close to the device body, of the bed body; a large C-shaped arm and a small C-shaped arm installed on the inner side of the large C-shaped arm are installed at the position of the notch of the device body, an X camera imager is installed at the upper end of the large C-shaped arm, and a shock wave generator and an ultrasonic probe installed on one side of the shock wave generator are installed on the small C-shaped arm. An energy adjusting module used for controlling the shock wave generator and a safety detection module used for detecting the skin temperature are arranged in the device body, and a displayer and a human-computer interaction interface are arranged on one side of the device body. The technical scheme in the prior art has limitations on shock wave generation, positioning precision, energy regulation and control and treatment strategies.

A wearable drug delivery device, techniques, and computer-readable media that provide an application that implements a diabetes treatment plan for a user are described. The drug delivery device may include a controller operable to direct operation of the wearable drug delivery device. The controller may provide a selectable activity mode of operation for the user. Operation of the drug delivery device in the activity mode of operation may reduce a likelihood of hypoglycemia during times of increased insulin sensitivity for the user and may reduce a likelihood of hyperglycemia during times of increased insulin requirements for the user. The activity mode of operation may be manually activated by the user or may be activated automatically by the controller. The controller may automatically activate the activity mode of operation based on a detected activity level of the user and / or a detected location of the user.

Exemplary embodiments described herein relate to a closed loop artificial pancreas system. The artificial pancreas system seeks to automatically and continuously control the blood glucose level of a user by emulating the endocrine functionality of a healthy pancreas. The artificial pancreas system uses a closed loop control system with a cost function. The penalty function helps to bound the infusion rate of insulin to attempt to avoid hypoglycemia and hyperglycemia. However, unlike conventional systems that use a generic or baseline parameter for a user's insulin needs in a cost function, the exemplary embodiments may use a customized parameter in the cost function that reflects the individualized insulin needs of the user. The use of the customized parameter causes the cost function to result in insulin dosages over time better suited to the individualized insulin needs of the user. This helps to better avoid hypoglycemia and hyperglycemia.

The invention provides a method for preparing quintuple diglyceride oil for improving blood vessel health through enzymolysis, application and a product, and belongs to the technical field of enzyme engineering. The preparation method comprises the following steps: mixing low-erucic acid rapeseed oil, glycerol, water, fatty acid and lipase, and carrying out enzymolysis reaction, molecular distillation, decoloration and deodorization to obtain diglyceride oil; the lipase is a mixture of Candida antarctica Aspergillus niger lipase, Candida column lipase and bovine pancreas lipase, and the weight ratio of the low-erucic acid rapeseed oil to the glycerin to the water to the fatty acid to the lipase is 500: (80-100): (1-2): (30-60): (10-20). The diglyceride oil prepared by the method can be used for preparing a diglyceride oil composition, and has five functions of reducing blood uric acid, reducing blood total cholesterol, reducing blood triglyceride, reducing blood sugar and increasing blood flow velocity to improve blood vessel health.

The invention relates to a lactic acid bacterium capable of reducing fat, resisting inflammation and reducing blood sugar, which is classified and named as pediococcus acidilactici XJ335, and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.30093, the preservation date is March 22, 2024, and the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The strain can achieve the fat reducing effect by adjusting the abundance of intestinal flora; the levels of IL-6 and TNF-alpha in serum of diabetic mice are remarkably improved through regulation, so that the anti-inflammatory effect is achieved; various cardiovascular diseases of atherosclerosis are prevented by adjusting the levels of TC, TG, HDL-C and LDL-C; by reducing FINS and HOMA-IR levels and improving HOMA-IS, HOMA-beta and QUICKI value levels, insulin resistance of a body is reduced, insulin sensitivity and pancreas islet beta cell functions of the body are improved, gene expression related to blood sugar regulation is regulated, and an excellent blood sugar reducing effect is achieved in the body.

The invention discloses a method and a device for performing focus detection on a pancreatic ultrasonic endoscope image, and belongs to the field of computer-aided diagnosis and image data processing. According to the method, a focus detection model capable of processing two tasks of disease classification and image focus segmentation is constructed, the focus detection model is trained by constructing a pancreas ultrasonic endoscope image data set with a real label, and focus detection is performed on an input pancreas ultrasonic endoscope image by using the trained focus detection model. The disease type and the lesion area in the segmented image can be accurately predicted, the lesion detection model can be optimized through fine tuning in clinical application, and the prediction accuracy and applicability are improved.

The invention relates to the technical field of medical monitoring, in particular to an intelligent monitoring and health management system for liver, gall and pancreas postoperative drainage fluid, which comprises a data acquisition module for acquiring core specific indexes of liver, gall and pancreas special drainage fluid, visual images of the drainage fluid, dynamic flow and physiological data of a patient; the intelligent analysis module constructs a hepatobiliary pancreatic postoperative exclusive multi-modal model, deeply couples postoperative disease course time sequence characteristics to identify risks at different stages after the operation, and triggers risk assessment when the operation is abnormal; the early warning module is provided with a light, medium and heavy three-level mechanism, and carries out resource adaptation type grading accurate pushing to a responsible physician and a nurse station terminal in combination with a medical care real-time load and a spatial distance. The health management module fuses individual features of the patient and real-time monitoring data, and constructs a personalized rehabilitation scheme in combination with rehabilitation feedback of the patient; and the data synchronization module transmits model update parameters through an encryption channel, and perfects the complete-cycle health archive of the patient. Therefore, the problems that in the prior art, an early warning mechanism is rigid, and data security and full-period management are insufficient are solved.

The present disclosure relates to a Lactococcus lactis subsp. lactis CAB701 strain having both anti-obesity and immune-promoting activities, an anti-obesity or immune-enhancing food composition containing the same, and an anti-obesity or immune-enhancing vegan fermented milk containing the same. The CAB701 strain of the present disclosure has pancreatic lipase inhibitory activity and can be widely utilized for preventing, ameliorating or treating obesity and for enhancing immunity. Furthermore, it can be used as a starter for fermentation. In addition, since a vegan fermented milk prepared with the CAB701 strain of the present disclosure exhibits a significantly slower decrease in the viable Lactobacillus cell count during the storage period as compared to vegan fermented milks prepared with conventional strains, it can be seen that the CAB701 strain of the present disclosure is useful in the preparation of a vegan fermented milk.

The invention relates to recombinant pichia pastoris for high expression of porcine pancreatic phospholipase A2 and application of the recombinant pichia pastoris, and belongs to the technical field of genetic engineering. According to the method disclosed by the invention, a vacuole sorting receptor Vps10 is knocked out by utilizing a CRISPR-Cas9 system, a CPY sorting way between a trans-golgi apparatus and a vacuole is interrupted, and ppPLA2 degradation is reduced; then, in order to relieve unfolded protein response in the endoplasmic reticulum, molecular chaperones are introduced into the genome, and synthesis of ppPLA2 is enhanced; the expression intensity of the ppPLA2 is improved by increasing the gene copy number of the ppPLA2; and finally, high-density fermentation is performed in a 3-L bioreactor, so that high-efficiency expression of the ppPLA2 in the pichia pastoris is realized.

The invention discloses a lactobacillus plantarum MW 2406C, which is preserved in China General Microbiological Culture Collection Center (CGMCC) on January 9, 2025, and the preservation number of the lactobacillus plantarum MW 2406C is CGMCC No. 33339. The inventor finds that the bacterial strain has better oxidation resistance, pathogenic bacterium inhibition and oxygen resistance, and can be used for effectively fermenting feed, pre-decomposing nutritional ingredients in the feed and improving the utilization efficiency of the feed; in addition, the strain can improve liver and intestine health and improve immunity by enhancing hepatopancreas antioxidant enzyme activity and intestinal digestive enzyme activity, improving intestinal barrier health, up-regulating antibacterial peptide level and reducing inflammatory factors. When the lactobacillus plantarum is used for preparing the fermented feed for the river crabs, the utilization efficiency of the compound feed by the river crabs is improved, the intestinal health of the river crabs is improved, and the disease resistance is improved.

The invention discloses an anti-lipopolysaccharide factor rALF-like protein and application thereof, and belongs to the technical field of molecular biology. The anti-lipopolysaccharide factor rALF-like protein provided by the invention belongs to secretory protein, the rALF-like protein can be competitively combined with an LPS structural domain of bacteria to achieve the purpose of inhibiting inflammation, and the expression of the coding gene Pv-ALF-like gene in blood cells, hepatopancreas, gill and intestinal tissues is remarkably up-regulated, so that the anti-lipopolysaccharide factor rALF-like protein can be used for inhibiting inflammation. The rALF-like protein disclosed by the invention has antibacterial and antiviral effects, lays a foundation for developing antibacterial and antiviral drugs and functional feed additives, and plays an important role in improving the resistance link of prawns.

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

The invention relates to a heparinized gelatin / sodium alginate pancreas islet packaging material with an anti-fibrosis function as well as a preparation method and application of the heparinized gelatin / sodium alginate pancreas islet packaging material. The preparation method comprises the following steps: adding gelatin into normal saline, soaking, performing autoclaved sterilization to obtain a gelatin solution, then adding epsilon-polylysine hydrochloride into the gelatin solution, and finally adding glutamine transaminase for reaction to obtain an epsilon-polylysine grafted gelatin solution; adding heparin into the solution, and reacting to obtain a heparinized gelatin solution; adding sodium alginate and glutamine transaminase, reacting, diluting, preparing hydrogel microspheres by adopting an electrostatic spraying method, and cross-linking to obtain the hydrogel microspheres. According to the invention, heparin molecules are incorporated into a pancreas islet packaging system, so that fibrosis at the periphery of the microspheres can be relieved, the pancreas islet cells are packaged by using the pancreas islet packaging material to prepare the biological artificial pancreas, the pancreas islet cell proliferation and insulin secretion can be promoted, and the pancreas islet packaging material has a good diabetes treatment effect.

Compositions and methods for assessing relative macromolecule abundance (for example, RNA expression levels) in a spatially-defined manner across a tissue sample (for example, from brain, lung, liver, kidney, pancreas, and / or heart) are disclosed, specifically providing deep transcriptomic coverage at high-resolution (for example, at approximate 10 μm (single cell) resolution) across multiple locations assessed across the tissue sample.

The present application belongs to the field of aquaculture technology, and mainly relates to a traditional Chinese medicine composition for preventing and treating acute hepatopancreas necrosis disease of prawn, a preparation method and application. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 28-32 parts of Radix Sanguisorbae, 28-32 parts of Radix Scutellariae, 18-22 parts of Phellodendri Cortex and 8-12 parts of Lonicerae Japonicae Flos. The traditional Chinese medicine composition can significantly inhibit the activity of the main pathogen of the disease, i.e. Vibrio parahaemolyticus, improve the immune function and disease resistance of prawn, and further repair the hepatopancreas and intestinal tissues of the diseased prawn, thereby achieving the effect of effectively preventing and treating the acute hepatopancreas necrosis disease of prawn.