577 results about "Pancreas" patented technology

Systems and methods for cooling a biological sample with different temperature cooling blocks. Warmer cooling blocks can be placed around a container and cooler cooling blocks can be placed above the container. The biological sample can be a pancreas, heart or other organs. The method and system can rely on convection, or gravity-based fluid movement, to make the temperature within the container consistent.

The invention discloses a human pancreas islet function digital evaluation method and system based on an AI algorithm, and relates to the technical field of artificial intelligence medical evaluation, and the method comprises the steps: collecting and preprocessing multi-modal physiological data; extracting multi-source features to generate a low-dimensional input vector; performing dynamic weighted fusion based on a space-time attention mechanism; constructing a neural differential equation model in which a beta cell two-phase secretion mechanism is introduced, and outputting pancreas islet function evaluation indexes; and a dynamic evaluation report is generated through a visualization and early warning module. According to the method, the modeling accuracy of the pancreas islet function under the interference of complex behaviors can be improved, the individualized quantitative evaluation of function decline trend prediction and sensitivity scoring is realized, the clinical staging reference value and the model interpretation ability are enhanced, and the technical problems of low fusion precision, poor dynamic nature and lack of physiological constraints in the existing method are solved.

The invention relates to the technical field of radiotherapy, in particular to a space-time compensation method and system for radiotherapy of pancreas respiratory movement variability, and the method comprises the steps: setting an infrared reflective mark point on the body surface of a patient, and obtaining a body surface three-dimensional CT image and an infrared camera real-time image under respiratory movement; establishing a pancreas three-dimensional model, a CTV target region model and a respiratory movement model; predicting body surface mark point displacement by adopting a long-short-term memory network algorithm and generating a respiration curve; determining a pancreas three-dimensional coordinate motion state; predicting lung motion by using optical flow motion estimation, and reversely solving a pancreas motion trail; determining the opening and closing states of the blades of the multi-blade collimator; according to the method, the mapping relation between lung movement and pancreatic movement is established through reverse mapping, an improved optical flow movement estimation algorithm and an LSTM network are adopted to predict respiratory movement, and the CTV leakage volume can be remarkably reduced to 0.4 cm from 2.1 cm of a traditional gating technology.

The invention provides a traditional Chinese medicine composition and an application thereof in preparing a product for preventing, alleviating or treating acute hepatopancreatic necrosis of shrimp, belonging to the field of veterinary medicine. The active ingredients of the traditional Chinese medicine composition include isatis root, artificial bezoar, liquorice, borneol, pig gall powder and xuanming powder. The traditional Chinese medicine composition has a good therapeutic effect on preventing, alleviating or treating acute hepatopancreatic necrosis of shrimp, with a cure rate of more than 70%, has antibacterial and liver-protecting effects, can effectively improve the degree of liver damage, improve the survival rate of shrimp and reduce losses.

A three-dimensional scaffold for use in engineered tissue includes a repeated 3D geometry; and at least one of a hydrogel, a biocompatible polymer, and a bioprintable polymer. The repeated 3D geometry may include an open geometry including a plurality of interconnected nodes configured to be seeded with living cells. The scaffold may be formed via bioprinting. The three-dimensional scaffold may also be used for (1) 3D tissue modelling (for liver, kidney, gut, pancreas, heart, lung, spleen, etc.), (2) disease modeling of different tumor types such as breast, colorectal, lung, liver, brain, ovarian and others, (3) drug testing / therapeutic screening of small molecule drugs, peptides, proteins, antibodies, ADCs, gene therapies, RNA-based therapeutics, cell therapies, and tissue therapies, and (4) therapeutic / drug delivery (i.e., via delivery device that can be used to control drug release based on different patterns).

The invention discloses a CNN-Transform method based on multi-scale feature interaction, and mainly relates to the technical field of medical image analysis. Comprising the following steps: S1, acquiring sufficient amount of pancreas and tumor CT data, labeling the data, defining an ROI (Region of Interest), and distributing corresponding labels; s2, dividing the data set obtained in the step S1 into a training set and a test set, and preprocessing the training set and the test set by a data enhancement method including random rotation, scaling and mirroring; and S3, a CNN-Transform pancreas and tumor segmentation model PanUNet based on multi-scale feature interaction is constructed. Visual and accurate image information can be provided for doctors through accurate pancreas and tumor segmentation, personalized treatment schemes can be formulated in time, and the survival rate of patients is increased.

The invention belongs to the technical field of image segmentation, and relates to a semi-supervised pancreatic image segmentation method based on prototype estimation and prototype consistency. According to the method, based on a semi-supervised segmentation framework of an average teacher, V-Net is adopted as a deep learning segmentation model, and a projection head is inserted in the last but one stage of a decoder as a prototype branch; prototype learning design prototype estimation is introduced, unmarked data prediction is divided into determined areas of fuzzy areas, and different losses are designed for areas with different reliability of the unmarked data. The problems that in an existing semi-supervised learning segmentation method, unmarked data cannot be fully utilized, potential information of marked data is insufficient in utilization and the like are effectively solved, and a higher-performance solution is provided for an abdominal CT image pancreatic organ segmentation task.

The invention discloses a radionuclide labeled molecular probe for detecting collagen structure denaturation and a preparation method and application thereof, and relates to the technical field of biology. The structural general formula of the radionuclide labeled molecular probe disclosed by the invention is as follows: K (chelating agent-nuclide)-K-Linker-CHP, wherein K (chelating agent-nuclide) is a lysine residue labeled by a side chain amino coupling chelating agent and a radionuclide; the Linker is a connection joint; cHP is a collagen hybrid peptide with a polypeptide sequence of (GfO) n or (GPO) n. The probe has excellent definition and signal-to-noise ratio, not only can detect pancreatic ductal adenocarcinoma in a pancreatic cancer model, but also can sensitively detect precancerous lesions (such as pancreatic intraepithelial neoplasia lesions) of the pancreatic ductal adenocarcinoma and pulmonary fibrosis lesions in a bleomycin pulmonary fibrosis model. And the kit has important significance on early detection of pancreatic duct adenocarcinoma and reflection of dynamic change of ECM remodeling.

The invention provides a gamma delta T cell preparation as well as a preparation method and application thereof, and belongs to the technical field of T cells. The liposome is prepared from the following raw materials in parts by weight: 15-20 parts of modified gamma delta T cell liposome, 1-3 parts of cell stimulating factors and 4-7 parts of culture medium freeze-dried powder, the modified gamma delta T cell lipidosome is prepared by embedding gamma delta T cells through lipidosome, coupling with acetylenic bond modified chitosan, and further mixing with MFAP4 protein and b4GALT1 protein. The culture medium freeze-dried powder is prepared by freeze-drying the culture medium in the engineering culture process of gamma delta T cells, and the cell stimulating factors are resveratrol and quercitrin. According to the gamma delta T cell preparation prepared by the invention, the survival ability and resistance of gamma delta T cells are improved, the anti-tumor activity of the gamma delta T cells is improved, and the gamma delta T cell preparation has relatively good antioxidant and anti-inflammatory effects, reduces the inhibition of inflammation on an immune system and has a very good treatment effect on pancreatic ductal adenocarcinoma.

The invention discloses a liver, gall and pancreas clinical puncture sampling device in the technical field of medical instruments, which comprises a base, a mechanical arm is fixedly connected to the base, a puncture needle is arranged at the top end of the mechanical arm, a guide rail for mounting the puncture needle is fixedly connected to the top end of the mechanical arm, a pushing part is slidably matched with one side of the guide rail, and the puncture needle is fixedly connected with the pushing part. The base is further fixedly connected with a pump assembly and a fixed arm, the top end of the fixed arm is fixedly connected with a multi-mode integrated sensor, and the side wall of the fixed arm is fixedly connected with a controller. By integrating a plurality of functional layers, the puncture needle can achieve a plurality of functions in single puncture, the mechanical arm is controlled to guide the puncture process of the puncture needle and compensate respiratory movement displacement through model construction and displacement prediction of the controller, and bleeding stopping gel is sprayed in a self-adaptive mode through resistance borne during needle insertion, so that massive bleeding is avoided; therefore, the efficiency of the hepatobiliary pancreas puncture operation is improved, the possibility of tissue bleeding infection is reduced, and the painless treatment experience of a patient is improved.

The invention relates to the technical field of medical instruments, in particular to an electromagnetic focusing extracorporeal shock wave pancreatic lithotripsy device and method.The electromagnetic focusing extracorporeal shock wave pancreatic lithotripsy device comprises a device body, a bed body is installed on one side of the device body through a supporting frame, and a lithotripsy notch is formed in the side, close to the device body, of the bed body; a large C-shaped arm and a small C-shaped arm installed on the inner side of the large C-shaped arm are installed at the position of the notch of the device body, an X camera imager is installed at the upper end of the large C-shaped arm, and a shock wave generator and an ultrasonic probe installed on one side of the shock wave generator are installed on the small C-shaped arm. An energy adjusting module used for controlling the shock wave generator and a safety detection module used for detecting the skin temperature are arranged in the device body, and a displayer and a human-computer interaction interface are arranged on one side of the device body. The technical scheme in the prior art has limitations on shock wave generation, positioning precision, energy regulation and control and treatment strategies.

A wearable drug delivery device, techniques, and computer-readable media that provide an application that implements a diabetes treatment plan for a user are described. The drug delivery device may include a controller operable to direct operation of the wearable drug delivery device. The controller may provide a selectable activity mode of operation for the user. Operation of the drug delivery device in the activity mode of operation may reduce a likelihood of hypoglycemia during times of increased insulin sensitivity for the user and may reduce a likelihood of hyperglycemia during times of increased insulin requirements for the user. The activity mode of operation may be manually activated by the user or may be activated automatically by the controller. The controller may automatically activate the activity mode of operation based on a detected activity level of the user and / or a detected location of the user.

Exemplary embodiments described herein relate to a closed loop artificial pancreas system. The artificial pancreas system seeks to automatically and continuously control the blood glucose level of a user by emulating the endocrine functionality of a healthy pancreas. The artificial pancreas system uses a closed loop control system with a cost function. The penalty function helps to bound the infusion rate of insulin to attempt to avoid hypoglycemia and hyperglycemia. However, unlike conventional systems that use a generic or baseline parameter for a user's insulin needs in a cost function, the exemplary embodiments may use a customized parameter in the cost function that reflects the individualized insulin needs of the user. The use of the customized parameter causes the cost function to result in insulin dosages over time better suited to the individualized insulin needs of the user. This helps to better avoid hypoglycemia and hyperglycemia.

The invention provides a method for preparing quintuple diglyceride oil for improving blood vessel health through enzymolysis, application and a product, and belongs to the technical field of enzyme engineering. The preparation method comprises the following steps: mixing low-erucic acid rapeseed oil, glycerol, water, fatty acid and lipase, and carrying out enzymolysis reaction, molecular distillation, decoloration and deodorization to obtain diglyceride oil; the lipase is a mixture of Candida antarctica Aspergillus niger lipase, Candida column lipase and bovine pancreas lipase, and the weight ratio of the low-erucic acid rapeseed oil to the glycerin to the water to the fatty acid to the lipase is 500: (80-100): (1-2): (30-60): (10-20). The diglyceride oil prepared by the method can be used for preparing a diglyceride oil composition, and has five functions of reducing blood uric acid, reducing blood total cholesterol, reducing blood triglyceride, reducing blood sugar and increasing blood flow velocity to improve blood vessel health.

The invention relates to the technical field of medical monitoring, in particular to an intelligent monitoring and health management system for liver, gall and pancreas postoperative drainage fluid, which comprises a data acquisition module for acquiring core specific indexes of liver, gall and pancreas special drainage fluid, visual images of the drainage fluid, dynamic flow and physiological data of a patient; the intelligent analysis module constructs a hepatobiliary pancreatic postoperative exclusive multi-modal model, deeply couples postoperative disease course time sequence characteristics to identify risks at different stages after the operation, and triggers risk assessment when the operation is abnormal; the early warning module is provided with a light, medium and heavy three-level mechanism, and carries out resource adaptation type grading accurate pushing to a responsible physician and a nurse station terminal in combination with a medical care real-time load and a spatial distance. The health management module fuses individual features of the patient and real-time monitoring data, and constructs a personalized rehabilitation scheme in combination with rehabilitation feedback of the patient; and the data synchronization module transmits model update parameters through an encryption channel, and perfects the complete-cycle health archive of the patient. Therefore, the problems that in the prior art, an early warning mechanism is rigid, and data security and full-period management are insufficient are solved.

The invention relates to recombinant pichia pastoris for high expression of porcine pancreatic phospholipase A2 and application of the recombinant pichia pastoris, and belongs to the technical field of genetic engineering. According to the method disclosed by the invention, a vacuole sorting receptor Vps10 is knocked out by utilizing a CRISPR-Cas9 system, a CPY sorting way between a trans-golgi apparatus and a vacuole is interrupted, and ppPLA2 degradation is reduced; then, in order to relieve unfolded protein response in the endoplasmic reticulum, molecular chaperones are introduced into the genome, and synthesis of ppPLA2 is enhanced; the expression intensity of the ppPLA2 is improved by increasing the gene copy number of the ppPLA2; and finally, high-density fermentation is performed in a 3-L bioreactor, so that high-efficiency expression of the ppPLA2 in the pichia pastoris is realized.

The invention discloses a lactobacillus plantarum MW 2406C, which is preserved in China General Microbiological Culture Collection Center (CGMCC) on January 9, 2025, and the preservation number of the lactobacillus plantarum MW 2406C is CGMCC No. 33339. The inventor finds that the bacterial strain has better oxidation resistance, pathogenic bacterium inhibition and oxygen resistance, and can be used for effectively fermenting feed, pre-decomposing nutritional ingredients in the feed and improving the utilization efficiency of the feed; in addition, the strain can improve liver and intestine health and improve immunity by enhancing hepatopancreas antioxidant enzyme activity and intestinal digestive enzyme activity, improving intestinal barrier health, up-regulating antibacterial peptide level and reducing inflammatory factors. When the lactobacillus plantarum is used for preparing the fermented feed for the river crabs, the utilization efficiency of the compound feed by the river crabs is improved, the intestinal health of the river crabs is improved, and the disease resistance is improved.

The invention discloses an anti-lipopolysaccharide factor rALF-like protein and application thereof, and belongs to the technical field of molecular biology. The anti-lipopolysaccharide factor rALF-like protein provided by the invention belongs to secretory protein, the rALF-like protein can be competitively combined with an LPS structural domain of bacteria to achieve the purpose of inhibiting inflammation, and the expression of the coding gene Pv-ALF-like gene in blood cells, hepatopancreas, gill and intestinal tissues is remarkably up-regulated, so that the anti-lipopolysaccharide factor rALF-like protein can be used for inhibiting inflammation. The rALF-like protein disclosed by the invention has antibacterial and antiviral effects, lays a foundation for developing antibacterial and antiviral drugs and functional feed additives, and plays an important role in improving the resistance link of prawns.

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

The invention relates to a heparinized gelatin / sodium alginate pancreas islet packaging material with an anti-fibrosis function as well as a preparation method and application of the heparinized gelatin / sodium alginate pancreas islet packaging material. The preparation method comprises the following steps: adding gelatin into normal saline, soaking, performing autoclaved sterilization to obtain a gelatin solution, then adding epsilon-polylysine hydrochloride into the gelatin solution, and finally adding glutamine transaminase for reaction to obtain an epsilon-polylysine grafted gelatin solution; adding heparin into the solution, and reacting to obtain a heparinized gelatin solution; adding sodium alginate and glutamine transaminase, reacting, diluting, preparing hydrogel microspheres by adopting an electrostatic spraying method, and cross-linking to obtain the hydrogel microspheres. According to the invention, heparin molecules are incorporated into a pancreas islet packaging system, so that fibrosis at the periphery of the microspheres can be relieved, the pancreas islet cells are packaged by using the pancreas islet packaging material to prepare the biological artificial pancreas, the pancreas islet cell proliferation and insulin secretion can be promoted, and the pancreas islet packaging material has a good diabetes treatment effect.

Compositions and methods for assessing relative macromolecule abundance (for example, RNA expression levels) in a spatially-defined manner across a tissue sample (for example, from brain, lung, liver, kidney, pancreas, and / or heart) are disclosed, specifically providing deep transcriptomic coverage at high-resolution (for example, at approximate 10 μm (single cell) resolution) across multiple locations assessed across the tissue sample.

The present application belongs to the field of aquaculture technology, and mainly relates to a traditional Chinese medicine composition for preventing and treating acute hepatopancreas necrosis disease of prawn, a preparation method and application. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 28-32 parts of Radix Sanguisorbae, 28-32 parts of Radix Scutellariae, 18-22 parts of Phellodendri Cortex and 8-12 parts of Lonicerae Japonicae Flos. The traditional Chinese medicine composition can significantly inhibit the activity of the main pathogen of the disease, i.e. Vibrio parahaemolyticus, improve the immune function and disease resistance of prawn, and further repair the hepatopancreas and intestinal tissues of the diseased prawn, thereby achieving the effect of effectively preventing and treating the acute hepatopancreas necrosis disease of prawn.

An automated insulin delivery system provides an insulin injection that is computed by adding (i) the recommendation of an artificial neural network trained to mimic a constrained model predictive controller dosing rule from a neural network implementing an artificial pancreas (ii) a hypoglycemia mitigation system includeds a correction (one dose computed as the correction down to 110mg / dl based on prevailing continuous glucose monitoring and once an hour at most, unless there is a triggering BPS and G>180 mg / dl), and (iii) the current basal rate (output of the Performance Assessment System, (PAS)); that amount is then saturated by the Safety Supervision System, SSM. Finally, a priming bolus from the Bolus Priming System, BPS, is added to the total if the conditions for large glycemic excursions are detected, also saturated by SSM.

The invention belongs to the technical field of biological medicines, and particularly relates to an anti-fibrosis peptide fragment, a vaccine and a preparation method and application of the peptide fragment vaccine. In order to explore that the peptide fragment is used as a peptide fragment vaccine for fibrotic diseases, the invention provides an anti-fibrosis peptide fragment, a vaccine and a preparation method and application of the peptide fragment vaccine. According to the application disclosed by the invention, main histocompatibility compound restrictive peptide fragments from six protein sources of fibrosis-specific MAF, FNDC3A, TOP2A, TNS3, APBB2 and OLFML2b are taken as targets for treating and preventing fibrosis diseases, and the six peptide fragments are taken as vaccines, so that various fibrosis diseases are remarkably prevented and treated by inhibiting pathological change and collagenous fiber deposition caused by fibrosis, and the application has the advantages that the application range is wide, and the application prospect is wide. Fibrosis of lung, liver, pancreas and the like is included. The peptide fragment and the peptide fragment vaccine provided by the invention provide candidate schemes for future research on preventive and therapeutic vaccine transformation of fibrotic diseases.

To improve allele discrimination, the inventors adapted the system combining Cas13a detection sensitivity with allele-specific PCR amplification to propose CASPER (Cas13a Allele-Specific PCR Enzyme Recognition) as a new versatile, easy-to-implement, and highly sensitive method to detect low-frequency of sequence variant. CASPER enabled specific and sensitive detection of KRASG12D with low DNA input such as DNA extracted from patient's pancreatic ultrasound-guided fine-needle aspiration fluids. CASPER is easy to implement and a versatile reliable method virtually adaptable to any point mutation.

The invention relates to the technical field of biological medicines, in particular to a mesenchymal stem cell preparation for treating diabetes and a preparation method thereof. The stem cell preparation is prepared from the following components: umbilical cord mesenchymal stem cells and naringin coated SiO2, and preparation raw materials of the naringin coated SiO2 are prepared from the following components in parts by weight: 10 to 15 parts of tetraethoxysilane (TEOS), 4 to 6 parts of 3-mercaptopropyl oxysilane (MPTMS), 2 to 3 parts of naringin, 0.8 to 1.2 parts of succinic anhydride and 2 to 3 parts of cysteamine hydrochloride. The prepared stem cell preparation has synergistic blood lineage of each component, and can repair pancreas islet injury and inhibit inflammatory response.

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some embodiments, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some embodiments, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

This disclosure is directed to two cancer-associated fibroblast (CAP) subtypes, namely permissive (permCAF) and restraining (restCAF), in pancreatic ductal adenocarcinoma (PDAC), mesothelioma, urothelial carcinoma, or renal cell carcinoma. Methods are disclosed that describe how to identify a tumor sample as a perCAF or a restCAF subtypes. Methods are also disclosed that use the subtypes for diagnosis, prognosis, differential treatment, and treatment.

The invention discloses a liver, gall and pancreas patient symptom evaluation system based on multi-dimensional data, and relates to the technical field of liver, gall and pancreas symptom evaluation. The visual management platform is in communication connection with a data acquisition module, an abnormal symptom classification module, a symptom risk analysis module, a symptom risk classification module and a report generation module, and all the modules are in electric signal connection; the data acquisition module is used for collecting and preprocessing multi-dimensional index data of a liver function index, a biliary system index and a pancreas index of a patient. By integrating the multi-dimensional data of the liver function index, the biliary system index and the pancreas index, the health condition of the liver, gall and pancreas patient can be more comprehensively reflected, compared with a traditional single-dimensional evaluation method, the abnormal symptoms of the patient can be more accurately recognized, the possibility of misdiagnosis and missed diagnosis is reduced, and the diagnosis accuracy is improved. And personalized symptom risk assessment can be carried out according to specific data of each patient, so that the medical decision is more accurate.