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203 results about "Brain trauma" patented technology
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Apparel type robot for healing hand function and control system thereof
InactiveCN101181176AMechanical structure matchingEffective rehabilitationGymnastic exercisingChiropractic devicesCommunity orData information
The invention discloses a wearable hand function rehabilitation robot, which is mainly used for assisting the repeated movement function rehabilitation training of the patient with hand movement function disorder which is caused by stroke, brain trauma, spinal cord injury and peripheral nerve injury in communities or families. The robot system extracts the active movement will of the patient by detecting the multi-channel surface myoelectric signals of the affected hand and obtains the state of the affected limb by combining the data which is measured by an angle and force sensor to carry out the rehabilitation training of the affected hand by pneumatic muscle contraction assistance by using the intelligent control algorithm on the basis. The rehabilitation robot has multiple degrees of freedom, which can assist the affected hand to carry out multi-joint complex movement and inosculate the multi-sensor data information fusion during the rehabilitation process to be further used for the evaluation of rehabilitation effect, and the activity and the training interest of the patient can be improved by using the rehabilitation treatment virtual environment on a computer. The invention has the advantages of simple structure, flexible movement, safety and reliability, which can not only realize the rehabilitation training of the movement function of the affected hand, but can also be in line with the physiologic structure characteristics of human hands. The invention is more comfortable to wear.
Owner:HUAZHONG UNIV OF SCI & TECH
Antibodies against Nogo receptor
InactiveUS20050214288A1Promote neuronalPromote axonal regenerationBiological material analysisImmunoglobulins against cell receptors/antigens/surface-determinantsRisk strokeNervous system disease
The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.
Owner:HUMAN GENOME SCI INC
Substituted heterocyclic compounds and methods of use
The present invention relates to pyridines, pyrimidines and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
Owner:AMGEN INC
Nogo receptor-mediated blockade of axonal growth
Disclosed are NgR proteins and biologically active Nogo (ligand) protein fragments. Also disclosed are compositions and methods for modulating the expression or activity of the Nogo and NgR protein. Also disclosed are peptides which block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial or cerebral trauma, spinal cord injury, stroke or a demyelinating disease.
Owner:YALE UNIV
Composition comprising xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
InactiveUS20050220910A1Preventing cerebral agingEnhance memoryBiocideSugar derivativesRheumatismHeadaches
This invention provides compositions, methods and process of producing extracts from Xanthoceras sorbifolia. The extract comprises alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, saponins, tannins, acid, flavonoids and others. The composition can be used for treating cancer, arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder, impotence and premature ejaculation; for preventing cerebral aging; for improving memory, cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's disease or other diseases caused by cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder. This invention provides compounds comprising at least one sugar, a triterpene, such as Sapogenin, and at least one side chains at Carbon 21 and 22, such as Angeloyl groups. The compounds of the present have various pharmaceutical and therapeutic applications.
Owner:PACIFIC ARROW
Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
InactiveUS7727561B2Preventing cerebral agingEnhance memoryBiocideSugar derivativesRheumatismArthritis
Owner:PACIFIC ARROW
Enoxolone derivative, preparation method and uses
ActiveCN1762967AEasy to makeSolve solubilityAntibacterial agentsOrganic active ingredientsSolubilityInjury brain
The present invention provides one new kind of glycyrrhetic acid derivative with high water solubility, high absorption, no irritation to blood vessel and capacity of being prepared into injection, and its preparation process, medicinal composition and preparation. The glycyrrhetic acid derivative has excellent treating effect on acute and chronic hepatitis, bacterial hepatitis, viral hepatitis, cerebral ischemia / re-perfusion damage, brain injury and myocardial ischemia / re-perfusion damage.
Owner:SHANDONG LUYE PHARMA CO LTD
Substituted heterocyclic compounds and methods of use
The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof, wherein R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R1 is additionally substituted; and R2 is a substituted C1-6alkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
Owner:AMGEN INC
Composition comprising xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
InactiveUS20090263512A1Preventing cerebral agingEnhance memoryBiocideSugar derivativesRheumatismCoronary heart disease
Owner:PACIFIC ARROW
Injection composition containing oxiracetam and preparation method and application thereof
ActiveCN102552125AImprove stabilitySimple recipePowder deliveryOrganic active ingredientsChemical compositionOxiracetam
The invention provides an injection composition containing oxiracetam and a preparation method and an application thereof. The composition contains sodium hydroxide. The invention further provides a preparation method and an application of the medicinal composition. The composition is mainly used for improving memory and the memory learning function of a mentally retarded patient, and is suitablefor memory and amentia caused by symptoms such as mild or moderate vascular dementia, senile dementia, brain trauma and the like, or is taken as an auxiliary treatment medicament.
Owner:北京爱力佳医药科技有限公司
Ceruloplasmin and an antioxidant composition comprising the same and their uses as neuroprotective agent
A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a therapeutically effective amount of ceruloplasmin or a functional derivative thereof. The neuroprotective composition is characterized in that it protects neuronal cells from reactive oxygen species such as .O2- and .OH. In a preferred embodiment, the neuroprotective composition further comprises an antioxidant consisting of catalase or of an amphiphilic physiological antioxidative solution comprising a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.
Owner:WARNER LAMBERT CO LLC
Rat acceleration and deceleration brain trauma striking system
Owner:WEST CHINA HOSPITAL SICHUAN UNIV
General glycoside extract from tree peony root bark and its preparation method and uses thereof
The present invention provides one kind of total paeonoside extract and its preparation process as well as the application of the total paeonoside extract in preparing medicine for preventing and treating cardiac and cerebral vascular diseases. Specifically, the total paeonoside extract is used in preparing medicine for preventing and treating cerebral apoplexy, cerebral ischemia / re-perfusion damabe, brain trauma, senile dementia, etc.
Owner:SHANDONG LUYE PHARMA CO LTD
Terahertz wave attenuation total reflection imaging-based cerebral trauma tissue detection device
PendingCN106580264ARealize detectionIncreased sensitivityDiagnostic recording/measuringSensorsBrain traumaUltrasound attenuation
The present invention discloses a terahertz wave attenuation total reflection imaging-based cerebral trauma tissue detection device. Terahertz waves emitted by a terahertz source enters a terahertz beam splitter which forms a certain angle with the terahertz waves; one part of the terahertz waves is reflected by the terahertz beam splitter, and the reflected terahertz waves enter a first terahertz detector which is connected with the input end of a computer control system; terahertz waves transmitted by the terahertz beam splitter are used as incident light for brain tissue sample detection, sequentially pass through a first terahertz aspherical lens, a total-reflection prism used for accommodating a brain tissue sample, and a second terahertz aspherical lens, and are finally detected by a second terahertz detector; the total-reflection prism is fixed on a two-dimensional mobile platform; and the computer control system receives data received by the first terahertz detector and the second terahertz detector and the moving information of the two-dimensional mobile scanning platform. With the terahertz wave attenuation total reflection imaging-based cerebral trauma tissue detection device of the invention adopted, the imaging of a brain trauma tissue is realized, and the location of the brain trauma tissue and the size of a lesion can be accurately embodied.
Owner:TIANJIN UNIV
Free protein blood of pig injection and use thereof
InactiveCN101310728AImprove securityImprove biological activityPowder deliveryNervous disorderDiseaseWhole blood product
The invention discloses a pig blood protein-free extract preparation, pertaining to the technical field of biochemical drugs. The pig blood protein-free extract freeze-dried powder injection preparation is prepared by pig blood protein-free extract and an excipient, and the weight ratio of the pig blood extract and the excipient is 200: 30 to 500. The pig blood protein-free extract of the invention applies pig blood as a raw material source to replace calf blood in the preparation of drugs for the treatment of cerebral vascular diseases, the improvement of nervous function defects caused by cerebral ischemia and craniocerebral trauma and the treatment of peripheral blood disorder symptoms, thus producing the biochemical drugs with the same function, replacing the similar products with the calf blood source, becoming the best choice of drug for the treatment and the auxiliary treatment of cardiovascular and cerebrovascular diseases and having very wide range of clinical application prospect. The product of the invention adopts the pig blood as the raw material, compared with the similar calf blood products, the product has the product advantages of high safety and high biological activity; furthermore, as the raw material is easy to obtain, the cost is low, the production process is advanced, the period is short and the yield is high, the product of the invention has the price advantage compared with the similar calf blood products.
Owner:沈阳斯佳科技发展有限公司
Application of Danshensu in preparation of medicine for treating cerebrovascular diseases
The present invention provides application of Danshensu in preparation of medicine for treating cerebrovascular diseases, concretely relates to application of Danshensu in preparation of medicine for treating ischemic stroke, application of Danshensu in preparation of medicine for treating NMDA receptor derivation neurons in the brain damage, application of Danshensu in preparation of medicine for treating brain trauma. The invention also provides medicine composition containing Danshensu for treating cerebrovascular diseases, whose unit dose is 50-200mg.
Owner:YANTAI UNIV
Injectio of gastrodine, its preparing process and usage
InactiveCN1634091AGive full play to the pharmacological effectImprove bioavailabilityOrganic active ingredientsNervous disorderVeinMedicine
The invention provides a gastrodine injection, which comprises the forms of gastrodine water for injection and metal chelating agent, the invention also discloses its preparation and use. Wherein the preparation comprises depositing gastrodine with water, cold storing, ultrafiltration technology processing, and sterilizing. The injection can be used for treating brain trauma, megrims, nerve pain, cephalodynia and neurasthenia.
Owner:巴里莫尔制药(通化)有限公司
Antibodies against nogo receptor
ActiveUS7973139B2Promote regenerationPrevent or ameliorate one or more symptomsAnimal cellsImmunoglobulins against cell receptors/antigens/surface-determinantsRisk strokeNervous system disease
Owner:HUMAN GENOME SCI INC
System, business and technical methods, and article of manufacture for design, implementation, and usage of internet of things devices and infrastructure, social media architecture and general computing device security advancements
InactiveUS20200143085A1Low costIncrease incomeTelemetry/telecontrol selection arrangementsDigital data protectionSocial mediaThe Internet
Non-invasive brain and body injury and vital sign assessment monitors, as well as methods for providing Internet-enabled care and recovery services for related conditions and injuries are disclosed. The sensors may be enclosed in a head wrap known as a “skull cap”, or they may be worn on other parts of the body such as the wrist or ankle. The present invention relates to brain and body assessment monitors, and relates to detection of brain trauma, stroke, and other related injuries sustained during physical activity. The invention also covers providing Internet enabled healthcare provider care associated with such injuries as a consolidated system. The biometric sensor arrays can be used as part of an Internet of Things system that may utilize a blockchain or distributed ledger technology for storage of sensor data.
Owner:COONER JASON RYAN
Injection of mannite and glycerol and preparation method thereof
ActiveCN101732287AAvoid damageImproves and restores energy metabolismHydroxy compound active ingredientsPharmaceutical delivery mechanismDiseaseNeural cell
The invention discloses injection of mannite and glycerol, which contains mannite, glycerol and water for injection. Furthermore, the invention also discloses a method for preparing the injection, which comprises the following steps: taking the mannite and the glycerol, dissolving into the water for injection, filtering and filling. The injection of the mannite and the glycerol is clinically used for treating cerebrovascular diseases, brain trauma, cerebral tumors, intracranial inflammation and the diseases of acute and chronic intracranial hypertension, hydrocephalus and the like caused by other reasons. The injection of the mannite and the glycerol has the functions of lowering the intracranial pressure quickly and eliminating the hydrocephalus and can also avoid death because of acute renal failure caused by the injury of the kidney; the injection of the mannite and the glycerol suppresses the apoptosis of neural cells and achieves the function of protecting the brain; the function of lowering the intracranial pressure is stable and has long retention time; crystals occurring because of the change of the air temperature or in the processes of storage and transportation are eliminated; and the glycerol is used as a caloric agent and can improve and recover the energy metabolism of the important viscera of the heart, the brain, the kidney and the like during oxygen deficiency. The injection of the mannite and the glycerol is a very effective, stable and safe medicine for promoting urination and removing water clinically.
Owner:北京圣方达隆医药科技发展有限责任公司 +2
Substituted heterocyclic compounds and methods of use
The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
Owner:AMGEN INC
Ferulate compound and preparation method thereof
InactiveCN104592025AIncrease concentrationEffective treatmentOrganic active ingredientsSenses disorderBrain syndromesDisease
The invention relates to a ferulate compound as well as a preparation method thereof and application of the compound in preparing medicaments for treatment and / or prevention of angioneurotic headache, vertigo, neurasthenia, neurasthenia syndrome, traumatic brain syndrome and cerebrovascular diseases.
Owner:杨安民
Method and device to detect, monitor and promote neural regeneration and improvement of cognitive function in a subject suffering from neural injury
InactiveUS20140018299A1Bioreactor/fermenter combinationsNervous disorderCognitive skillClinical evaluation
Severe traumatic brain (TBI) injuries are often associated with long-term and disabling consequences. Prognosis and chronic treatment planning following severe TBI remain challenging. The discovery of specific brain biomarkers could create new opportunities for more accurate clinical assessments identifying groups that may experience better outcomes when exposed to an intervention. The present invention provides a method of detection of Microtubule-associated protein-2 (MAP-2), a marker of dendritic damage, in a biological sample of survivors after TBI and evaluates the recovery of the patient, including an improvement in cognitive abilities and function.
Owner:BANYAN BIOMARKERS INC
Traumatic brain injury protection devices
ActiveUS20180325194A1Reduce severityAvoid it happening againHead bandagesNeck bandagesPressure senseNeck collar
The disclosure provides neck collar devices and systems for the mitigation and prevention of traumatic brain injury, including concussion. Specifically disclosed are adjustable collars and systems, and collars having certain pressure sensing devices.
Owner:Q30 SPORTS SCI LLC
Substituted heterocyclic compounds and methods of use
The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof, wherein R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, 0 and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R1 is additionally substituted; and R2 is a substituted C1-6alkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
Owner:AMGEN INC
Compositions and methods for treatment of stroke and other CNS disorders
InactiveUS20200255530A1Pharmaceutical delivery mechanismImmunoglobulins against cell receptors/antigens/surface-determinantsDiseaseArachnoids
The invention relates to methods of treating stroke comprising administration of a VLA-4 antagonist to a subject after the onset of the stroke, e.g., ischemic stroke (e.g., acute ischemic stroke) or hemorrhagic stroke (e.g., intracerebral hemorrhage), sub-arachnoid hemorrhage, or traumatic brain injury. Kits and articles of manufacture are also described herein.
Owner:BIOGEN MA INC
Neuroprotective composition and uses thereof
InactiveUS20040235947A1Stabilizes cellular membranePromote normalizationBiocideNervous disorderSide effectNeuro-degenerative disease
Owner:PAQUIN JOANNE +2
Idebenone composition for the treatment of neurological disorders
The invention describes the use of an injectable form of Idebenone to induce protect from neuronal damage, improve recovery after brain trauma; stroke, intoxication, neurodegenerative diseases, memory loss or neuropathology associated with neuroinflammation or infection damage and to restore cognitive function, suppress disorientation, alcoholic and drug abuse associated syndromes and other signs of neuronal damage.
Owner:ALPHARX
Neuroprotection and neuroegenisis by administering cyclic prolyl glycine
InactiveUS7232798B2Promote myelin productionIncrease the effective amountBiocideNervous disorderNeuroprotective factorsAnticonvulsant
The invention relates to the use of cyclic Prolyl Glycine (“cyclic PG” or “cPG”) and analogs and mimetics thereof, as neuroprotective agents for the treatment and or prevention of neurological disorders including but not limited to cerebral ischemia or cerebral infarction resulting from a range of phenomena, such as thromboembolic or hemorrhagic stroke, cerebral basospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia such as from drowning, pulmonary surgery, and cerebral trauma, as well as to the treatment and prevention of chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and as anticonvulsants.
Owner:NEUROBIOMED
Neuroprotective composition and uses thereof
InactiveUS20020128316A1Stabilizes cellular membranePromote normalizationBiocideNervous disorderDiseaseAntioxidant
A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.
Owner:WARNER-LAMBERT CO
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