193 results about "Brain trauma" patented technology

The invention discloses a wearable hand function rehabilitation robot, which is mainly used for assisting the repeated movement function rehabilitation training of the patient with hand movement function disorder which is caused by stroke, brain trauma, spinal cord injury and peripheral nerve injury in communities or families. The robot system extracts the active movement will of the patient by detecting the multi-channel surface myoelectric signals of the affected hand and obtains the state of the affected limb by combining the data which is measured by an angle and force sensor to carry out the rehabilitation training of the affected hand by pneumatic muscle contraction assistance by using the intelligent control algorithm on the basis. The rehabilitation robot has multiple degrees of freedom, which can assist the affected hand to carry out multi-joint complex movement and inosculate the multi-sensor data information fusion during the rehabilitation process to be further used for the evaluation of rehabilitation effect, and the activity and the training interest of the patient can be improved by using the rehabilitation treatment virtual environment on a computer. The invention has the advantages of simple structure, flexible movement, safety and reliability, which can not only realize the rehabilitation training of the movement function of the affected hand, but can also be in line with the physiologic structure characteristics of human hands. The invention is more comfortable to wear.

The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.

The present invention relates to pyridines, pyrimidines and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

Disclosed are NgR proteins and biologically active Nogo (ligand) protein fragments. Also disclosed are compositions and methods for modulating the expression or activity of the Nogo and NgR protein. Also disclosed are peptides which block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial or cerebral trauma, spinal cord injury, stroke or a demyelinating disease.

The present invention provides one new kind of glycyrrhetic acid derivative with high water solubility, high absorption, no irritation to blood vessel and capacity of being prepared into injection, and its preparation process, medicinal composition and preparation. The glycyrrhetic acid derivative has excellent treating effect on acute and chronic hepatitis, bacterial hepatitis, viral hepatitis, cerebral ischemia/re-perfusion damage, brain injury and myocardial ischemia/re-perfusion damage.

The present invention relates to compounds having the general formula

or a pharmaceutically acceptable salt thereof, wherein R¹ is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R¹ is additionally substituted; and R² is a substituted C_1-6alkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

The invention provides an injection composition containing oxiracetam and a preparation method and an application thereof. The composition contains sodium hydroxide. The invention further provides a preparation method and an application of the medicinal composition. The composition is mainly used for improving memory and the memory learning function of a mentally retarded patient, and is suitablefor memory and amentia caused by symptoms such as mild or moderate vascular dementia, senile dementia, brain trauma and the like, or is taken as an auxiliary treatment medicament.

The invention discloses a rat acceleration and deceleration brain trauma striking system which comprises an experimental platform, a striking module, a striker module, a positioning module and an acceleration and deceleration trauma switching module. The positioning module is longitudinally and perpendicularly arranged on the experimental platform, the striking module is transversely and perpendicularly arranged on the positioning module, the striking module is placed on the experimental platform, the striker module is arranged at the position, arranged between the positioning module and the striking module, of the experimental platform, and the acceleration and deceleration trauma switching module is arranged on the side edge, longitudinally and perpendicularly corresponding to the striking module, of the experimental platform. Compared with the prior art, the system can precisely manufacture a rat brain trauma model, the repeatability is good, the operation is easy, a rat does not easily die, the acceleration brain trauma model and a deceleration brain trauma model can be manufactured, trauma grading can be carried out on the manufactured models, a matched group of a brain opening cavity and a brain non-opening cavity can be manufactured, and a large amount of support can be provided for research for the human brain trauma.

The present invention provides one kind of total paeonoside extract and its preparation process as well as the application of the total paeonoside extract in preparing medicine for preventing and treating cardiac and cerebral vascular diseases. Specifically, the total paeonoside extract is used in preparing medicine for preventing and treating cerebral apoplexy, cerebral ischemia/re-perfusion damabe, brain trauma, senile dementia, etc.

The present invention discloses a terahertz wave attenuation total reflection imaging-based cerebral trauma tissue detection device. Terahertz waves emitted by a terahertz source enters a terahertz beam splitter which forms a certain angle with the terahertz waves; one part of the terahertz waves is reflected by the terahertz beam splitter, and the reflected terahertz waves enter a first terahertz detector which is connected with the input end of a computer control system; terahertz waves transmitted by the terahertz beam splitter are used as incident light for brain tissue sample detection, sequentially pass through a first terahertz aspherical lens, a total-reflection prism used for accommodating a brain tissue sample, and a second terahertz aspherical lens, and are finally detected by a second terahertz detector; the total-reflection prism is fixed on a two-dimensional mobile platform; and the computer control system receives data received by the first terahertz detector and the second terahertz detector and the moving information of the two-dimensional mobile scanning platform. With the terahertz wave attenuation total reflection imaging-based cerebral trauma tissue detection device of the invention adopted, the imaging of a brain trauma tissue is realized, and the location of the brain trauma tissue and the size of a lesion can be accurately embodied.

The invention provides a gastrodine injection, which comprises the forms of gastrodine water for injection and metal chelating agent, the invention also discloses its preparation and use. Wherein the preparation comprises depositing gastrodine with water, cold storing, ultrafiltration technology processing, and sterilizing. The injection can be used for treating brain trauma, megrims, nerve pain, cephalodynia and neurasthenia.

Non-invasive brain and body injury and vital sign assessment monitors, as well as methods for providing Internet-enabled care and recovery services for related conditions and injuries are disclosed. The sensors may be enclosed in a head wrap known as a “skull cap”, or they may be worn on other parts of the body such as the wrist or ankle. The present invention relates to brain and body assessment monitors, and relates to detection of brain trauma, stroke, and other related injuries sustained during physical activity. The invention also covers providing Internet enabled healthcare provider care associated with such injuries as a consolidated system. The biometric sensor arrays can be used as part of an Internet of Things system that may utilize a blockchain or distributed ledger technology for storage of sensor data.

The invention discloses injection of mannite and glycerol, which contains mannite, glycerol and water for injection. Furthermore, the invention also discloses a method for preparing the injection, which comprises the following steps: taking the mannite and the glycerol, dissolving into the water for injection, filtering and filling. The injection of the mannite and the glycerol is clinically used for treating cerebrovascular diseases, brain trauma, cerebral tumors, intracranial inflammation and the diseases of acute and chronic intracranial hypertension, hydrocephalus and the like caused by other reasons. The injection of the mannite and the glycerol has the functions of lowering the intracranial pressure quickly and eliminating the hydrocephalus and can also avoid death because of acute renal failure caused by the injury of the kidney; the injection of the mannite and the glycerol suppresses the apoptosis of neural cells and achieves the function of protecting the brain; the function of lowering the intracranial pressure is stable and has long retention time; crystals occurring because of the change of the air temperature or in the processes of storage and transportation are eliminated; and the glycerol is used as a caloric agent and can improve and recover the energy metabolism of the important viscera of the heart, the brain, the kidney and the like during oxygen deficiency. The injection of the mannite and the glycerol is a very effective, stable and safe medicine for promoting urination and removing water clinically.

The present invention relates to compounds having the general formula

or a pharmaceutically acceptable salt thereof. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

The present invention relates to compounds having the general formula

or a pharmaceutically acceptable salt thereof, wherein R¹ is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, 0 and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R¹ is additionally substituted; and R² is a substituted C_1-6alkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

The invention relates to methods of treating stroke comprising administration of a VLA-4 antagonist to a subject after the onset of the stroke, e.g., ischemic stroke (e.g., acute ischemic stroke) or hemorrhagic stroke (e.g., intracerebral hemorrhage), sub-arachnoid hemorrhage, or traumatic brain injury. Kits and articles of manufacture are also described herein.

The invention describes the use of an injectable form of Idebenone to induce protect from neuronal damage, improve recovery after brain trauma; stroke, intoxication, neurodegenerative diseases, memory loss or neuropathology associated with neuroinflammation or infection damage and to restore cognitive function, suppress disorientation, alcoholic and drug abuse associated syndromes and other signs of neuronal damage.

The invention relates to the use of cyclic Prolyl Glycine (“cyclic PG” or “cPG”) and analogs and mimetics thereof, as neuroprotective agents for the treatment and or prevention of neurological disorders including but not limited to cerebral ischemia or cerebral infarction resulting from a range of phenomena, such as thromboembolic or hemorrhagic stroke, cerebral basospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia such as from drowning, pulmonary surgery, and cerebral trauma, as well as to the treatment and prevention of chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and as anticonvulsants.

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

The present invention relates to the detection of traumatic brain injury by detecting Aβ protein aggregates associated with traumatic brain injury. These Aβ protein aggregates are detected using peptide and peptide mimic probes that preferentially associate with Aβ protein aggregates associated with traumatic brain injury.

The invention provides a multifunctional limb training device for patients with cerebral trauma, which belongs to the technical field of medical apparatus and instruments. The patients with serious cerebral trauma caused by high-altitude tumble injury or traffic accidents are very slow to recover the acting function of limbs by utilizing the prior training mode. The invention adopts a technical proposal that an upper support frame (6) is fixed on bedstead legs (1) with universal wheels (4); an angle-steel bedstead (2) is fixed on the bedstead legs (1); a plurality of bedplates (3) are transversely placed on the angle-steel bedstead (2); a handrail (5) is fixed on the angle-steel bedstead (2); an upper left transverse brace (7), an upper right transverse brace (8), a lower left transverse brace (9) and a lower right transverse brace (10) are fixed on the upper support frame (6) respectively; and a left pulley (12) and a right pulley (11) are arranged on the upper left transverse brace (7) and the upper right transverse brace (8) respectively. The device has the advantages that the patients can realize the comprehensive training of cerebral functions and limb functions and realize rapid rehabilitation by utilizing the device which integrates a plurality of functions.

The invention relates to application of 3, 4-dihydro-2H-benzo-[1, 4] oxazine or salt of the oxazine in preparing drugs for inhibiting iron death, especially to application of 3, 4-dihydro-2H-benzo-[1,4] oxazine compounds or salt of the oxazine in preparing drugs for treating diseases associated with iron death, and the diseases associated with iron death include brain trauma, stroke, cardiovascular diseases, liver and kidney failure, inflammation and neurodegenerative diseases such as Parkinson's disease and schizophrenia.