10 results about "Injury model" patented technology

The invention provides a knee joint personalized rehabilitation scheme generation method and system based on digital twinning, and the method comprises the steps: obtaining the multi-dimensional feature data of a patient to construct a patient rehabilitation data set, constructing a knee joint injury knowledge graph based on the patient rehabilitation data set, constructing a knee joint minimal injury model based on the knee joint injury knowledge graph, and generating a knee joint personalized rehabilitation scheme. Functional weak links and injury degrees of the patient during rehabilitation training are accurately recognized, a data basis is provided for subsequently formulating a personalized scheme for the condition of the patient, emotion extraction is performed on voice feedback data in a patient rehabilitation data set, the patient emotion index is obtained, rehabilitation efficiency diagnosis is performed according to the patient emotion index, and the rehabilitation efficiency of the patient is improved. According to the method, the initial rehabilitation scheme of the knee joint is generated, the initial rehabilitation scheme of the knee joint is subjected to efficiency evaluation and scheme optimization, and the rehabilitation scheme of the knee joint is generated, so that the rehabilitation scheme is dynamically adjusted according to the personalized requirements of the patient while the personalized requirements of the patient are met, and the accuracy and efficiency of the generated rehabilitation scheme are improved.

The present application relates to the technical field of medical service support, and particularly relates to a personnel vulnerability analysis method for precise medical service support, comprising: target analysis: dividing a human body into parts according to human body functions or professional functions; establishing a human body injury spectrum based on each human body part; constructing an injury model: the plurality of injury models include a projectile injury model, a thermal injury model, a shock wave injury model and an impact vibration injury model; constructing a mapping relationship under various working conditions: calculating physical injury and functional injury under a preset strike working condition based on the injury model; obtaining vulnerability distribution law: performing personnel vulnerability analysis according to the human body injury spectrum and the injury model to obtain the vulnerability distribution law and statistical results under the preset strike working condition. The present application can obtain accurate medical service support data, so that the medical service support data is more stable, scientific, reasonable and accurate.

The invention discloses a carbon tetrachloride damage model construction and nutrition intervention evaluation method based on a three-dimensional liver chip, and belongs to the technical field of microfluidics and biological medicines. According to the method, an in-vitro bionic liver tissue model is constructed by utilizing a three-dimensional liver chip, liver cell injury is induced by perfusing carbon tetrachloride, on the basis, substances such as algae-derived extracellular vesicles are added for repairing intervention, and meanwhile, contrastive analysis is performed with a two-dimensional plate culture system. Results show that the secretion level and the function maintenance time of albumin, urea and the like of liver cells in a liver chip model are superior to those of two-dimensional culture, and after nutrient intervention is carried out, liver injury indexes such as ALT, AST and the like in the chip model are remarkably reduced, and the cell activity and the metabolic function are obviously recovered. The model can be used for evaluating the curative effect of nutrient substances on chemical liver injury, overcomes animal experiment species difference and two-dimensional culture limitation, provides an efficient and sensitive in-vitro research platform for medicine and nutrition function screening, and has wide application prospects and industrialization potential.

The invention provides a method for evaluating the repair activity of a test substance, which comprises the following steps: constructing a 3D epidermis injury model, treating the injured epidermis by using the test substance, detecting the secretion amounts of IL-8 and MCP-1 in the epidermis before and after treatment, and evaluating the repair activity of the test substance based on the secretion amounts of IL-8 and MCP-1, the evaluation result obtained by the method is consistent with the evaluation result of efficacy verification performed by using a human body in trend, the blank of in-vitro evaluation of the injury repair efficacy is filled, a feasible scheme is provided for animal replacement experiments, and a reference basis is provided for further research of skin care product development and efficacy verification.

The invention discloses a construction method and application of an animal skin injury model, and relates to the technical field of biomedicine. According to the construction method, based on the microneedle technology, through the integrated design of parameter quantification control, operation standardization, injury form customization and recovery cycle regulation and control, precision, diversification and standardization of the animal skin injury model are achieved. According to the method, unified operation specifications are formulated by relying on a quantifiable parameter system of a sterile fixed microneedle and combining animal skin characteristics, it is ensured that the damage depth / area deviation of models of the same batch and different batches is controllable, and stable construction of the animal standardized skin damage model is achieved; accurate control of'epidermis-dermis' layered gradient injury is realized through accurate matching of microneedle parameters and skin levels; according to the invention, polymorphic injury customization is also realized: diversified injury types are generated through combination of an operation mode and microneedle parameters; and key design of continuous damage and recovery period regulation and control.

The application discloses a kind of based on AI mouse cranium brain thoracic and abdominal complex injury dynamic model preparation method and system, belong to the technical field of biomechanics injury.The method comprises: impact is applied to mouse skull, the impact is conducted along organ synergistic conduction chain, to induce the cranium brain thoracic and abdominal complex injury of mouse;In the process of applying impact, multi-modal physiological data are synchronously collected;The multi-modal physiological data collected are input to AI analysis model, the injury mechanism of the cranium brain thoracic and abdominal complex injury is analyzed, and dynamic model is established based on analysis result.The technical scheme of the present application realizes the high simulation modeling of multiple organ cascade injury by constructing organ synergistic conduction chain from cranium to thoracic cavity;Combined with multi-modal physiological data synchronous acquisition and AI analysis model, the injury timing characteristics can be accurately extracted, the causal path of local injury triggering system response is established, and the accuracy and practicality of complex injury mechanism prediction are improved.

The invention discloses a construction method and application of a zebra fish tail fin ischemia injury model with both inflammatory response and regeneration capacities, rose bengal is injected into the abdominal cavity of a zebra fish, then the zebra fish tail fin ischemia injury model is constructed by performing local fluorescence irradiation on the tail fin of the zebra fish and performing photochemical induced injury, the operation is simple and convenient, and the construction method is suitable for large-scale popularization and application of the zebra fish tail fin ischemia injury model. And the death rate of the zebrafish in one day after modeling of the zebrafish is very low (only 5.3%), and the method has good repeatability and operability. The photochemically induced caudal fin injury model has pathological characteristics closer to clinical tissue injury, can simulate inflammation and regeneration processes at the same time, and has dual application potentials of drug screening and mechanism research.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for protecting gastric mucosa and application. The raw material of the traditional Chinese medicine composition is Corydalis and Fructus Meliae, and the preparation method comprises the following steps: firstly, Corydalis is extracted with water, and filtered to obtain Corydalis extract and Corydalis residue; then, Fructus Meliae and the Corydalis residue are mixed with water, and enzyme is added for enzymolysis to obtain an enzymolysis solution; finally, the Corydalis extract and the enzymolysis solution are mixed, sterilized, fermented with probiotic bacteria liquid, and filtered to obtain the traditional Chinese medicine composition. The composition prepared by the preparation method has a significantly better protection effect on gastric mucosa than other methods due to the reasonable combination of Fructus Meliae and Corydalis, can significantly reduce the gastric mucosa lesion degree of experimental gastric mucosa injury model animals, and improve the repair ability of gastric mucosa.

The invention specifically discloses a platelet injury assessment method and device for a hemodialysis catheter, a medium and a program product, and the method comprises the steps: obtaining the actual structural characteristics and clinical standard size of the hemodialysis catheter, and carrying out the geometric modeling of the hemodialysis catheter; performing high-precision grid division and hemodynamic analog simulation on the geometric model of the hemodialysis catheter; setting boundary conditions of each fluid domain, and establishing a shear stress and vorticity coupled damage evaluation mechanism by introducing vorticity as coupling characterization of local shear stress and eddy current effect; calculating the vortex intensity and shear stress of the blood of the blood flow velocity field through the damage assessment mechanism, and constructing a blood damage model coupled with a time accumulation effect; particle statistical data are obtained through particle tracking in the hemodialysis catheter, and platelet injury calculation is carried out through a blood injury model. The accuracy of platelet injury estimation of the hemodialysis catheter can be improved.

The application provides doxorubicin and lapatinib in constructing a zebrafish cardiotoxicity damage model and a drug screening method, and belongs to the technical field of biological medicine and animal model construction. The application discloses that doxorubicin and lapatinib can be used in combination to construct a doxorubicin-related zebrafish cardiotoxicity damage model for the first time, and provides a method for establishing a zebrafish cardiotoxicity damage model. The heart index of the application is very comprehensive, and the zebrafish cardiotoxicity damage model constructed by the application can be used to screen drugs of various different action mechanisms which have an improving effect on heart damage.