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Ovateleaf Holly Bark extract product having hepatic injury prevention effect, and application thereof

A technology for liver damage and extract, applied in the field of medicinal plant holly bark - Rescue Bing, can solve problems such as no active extract, and achieve the effect of enhancing SOD activity

Inactive Publication Date: 2015-04-15
广西中医药大学附属瑞康医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no technology to prepare active extracts using jiubing as a raw material, and there is no report of using jiubing as a main component to prevent and treat liver damage.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The jiubing extract with anti-hepatic damage is prepared by the following method:

[0020] Grinding the jiubing into fine powder, extracting with ethanol 3 times, filtering, combining the extracts, and concentrating the extracts to obtain the extract; drying in vacuum to obtain the jiubing extract which has anti-hepatic damage effect.

Embodiment 2

[0022] The jiubing extract with anti-hepatic damage is prepared by the following method:

[0023] Grind Jiubingying to a fine powder of 80 meshes, 20 times the amount of 65% ethanol solvent ultrasonically assisted extraction for 3 times, filter, combine the extracts, concentrate the extracts to obtain the extract; vacuum dry, the acquired anti-liver damage effect The extract of Bingying; the ultrasonic-assisted extraction is at a working frequency of 40KHz, at a temperature of 40°C, and for 30 minutes.

Embodiment 3

[0025] Experimental Study on Anti-liver Injury of Active Extract of Jiubingying

[0026] 1. Experimental materials and equipment

[0027] 1.1 Experimental materials and reagents

[0028] Save Bing Extract, Chapter Three Preparation. ALT and AST kits, Nanjing Jiancheng Bioengineering Co., Ltd.

[0029] SOD and MDA kits, Nanjing Jiancheng Biological Engineering Co., Ltd.; bifendate dripping pills, Zhejiang Pharmaceutical Co., Ltd. Xinchang Pharmaceutical Factory, batch number 091103; CCl 4 and absolute ethanol (chemical grade), Beijing Chemical Plant;

[0030] Edible soybean oil, Coomassie brilliant blue, Nanjing Jiancheng Institute of Bioengineering; triglyceride (TG) kit, purchased from Beijing Beihua Kangtai Clinical Reagent Co., Ltd.; tissue fixative, Beijing Chemical Factory.

[0031] 1.2 Instruments

[0032] HC-2517 high-speed centrifuge, Anhui Zhongke Zhongjia Scientific Instrument Co., Ltd.; DK-98-1 electric heating constant temperature water bath, Tianjin Test Inst...

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PUM

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Abstract

The invention relates to an Ovateleaf Holly Bark extract product having a hepatic injury prevention effect, and an application thereof. Ovateleaf Holly Bark is dried bark or velamen of an Aquifoliaceae plant Ilex roundda Thunb.. The active extract product is prepared on the basis of researches of the traditional efficacies of Ovateleaf Holly Bark. The Ovateleaf Holly Bark extract product can substantially reduce the activity of ALT and AST in the serum of CCl4 / alcohol caused hepatic injury model mice and the content of MDA in hepatic tissues of the mice, and enhances the SOD activity of livers, so the active extract has an obvious hepatic protection effect on chemical hepatic injuries and alcoholic hepatic injuries.

Description

technical field [0001] The present invention relates to the bark of Ilex rotunda Thumb, a medicinal plant-the bark of Ilex rotunda Thumb, in particular to the extract of the bark of Ilex rotunda Thumb, which has the function of resisting liver damage, and its application. Background technique [0002] With the acceleration of social development and industrialization, the interference of more external factors and the living habits of human beings have led to a gradual increase in the incidence of liver diseases. At present, animal models of liver injury are mainly divided into acute liver injury and chronic liver injury, and CCl 4 It is a chemical agent commonly used to induce liver damage in animals. CCl 4 It can cause centrilobular necrosis in animals, which is very close to the toxic liver injury in humans. Its pathway of action is mainly through CCl 4 The metabolites of the metabolites lead to oxidative stress which stimulates lipid peroxidation and damages the liver....

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K36/34A61P1/16
CPCA61K36/185A61K36/34A61K2236/333A61K2236/39A61K2236/51
Inventor 赵立春
Owner 广西中医药大学附属瑞康医院
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