460 results about "Polythylene glycol" patented technology

The invention discloses a preparation method of a raspberry-derived exosome loaded with neroli essential oil. The preparation method comprises the following steps: preparing raspberry fruits into homogenate; centrifuging, collecting supernate, adjusting the pH value to 4.07.5, standing, and centrifuging again; taking supernate, adjusting the pH value to 7.2-7.4, adding polyethylene glycol, standing, centrifuging, collecting precipitate, and carrying out resuspension dispersion; performing microfiltration to obtain supernate, and combining electrophoresis dialysis and ultrafiltration concentration to obtain the high-purity raspberry exosome. And diluting the exosome, adding the diluted exosome into a dimethyl sulfoxide solution containing neroli essential oil, carrying out water bath stirring, carrying out ultrafiltration centrifugation, and taking a clear liquid to obtain the exosome loaded with the neroli essential oil. Efficient separation and purification of the raspberry exosome are achieved by applying an isoelectric precipitation technology, then the neroli essential oil is wrapped in the exosome, the stability of the essential oil is improved, the action time is prolonged, meanwhile, the neroli essential oil and active ingredients of the exosome generate a synergistic effect, and the antioxidant activity is jointly enhanced.

The invention relates to polyethylene glycol glycerol ricinoleate granules as well as a preparation method and application thereof. The granules comprise first polyethylene glycol glycerol ricinoleate with an HLB (Hydrophile-Lipophile Balance) value of 17-19, second polyethylene glycol glycerol ricinoleate with an HLB value of 12-14, a carrier and vitamin E acetate. According to the invention, fatty acid and / or hydrogenated vegetable oil are / is taken as a nutritional carrier, and polyethylene glycol glycerol ricinoleate with an HLB value of 12-14 is introduced, so that the dispersity of active ingredients with a high HLB value (17-19) in the carrier is effectively improved, and granulation is facilitated; meanwhile, the vitamin E acetate is added, so that the immunity of animals can be enhanced while the effects of resisting oxidation and prolonging the shelf life of the product are achieved. The granules solve the problems that pure products are not easy to mix, inconvenient to use and the like.

The invention discloses a biological challenge device with combined adjustable resistance for evaluating the effect of a sterilization process, which comprises a shell, the shell comprises a plastic pipe and an inner pipe cap detachably connected with the inner wall of the plastic pipe, the inner pipe cap is provided with a breathable window and covered by a breathable film, and a bacterial contamination carrier for bearing indicator biological spores is attached to the inner bottom of the plastic pipe. An openable container containing a liquid culture medium is arranged in the plastic pipe cavity; the outer side of the inner pipe cap is sleeved with an outer pipe cap detachably connected with the outer wall of the plastic pipe, and the outer pipe cap is provided with a flow blocking structure used for adjusting the speed of the sterilizing agent entering the area of the inner pipe cap; the indicator biological spores are pretreated by a stable protective agent containing one or more of polyethylene glycol, trehalose, sorbitol, polyvinylpyrrolidone and glyceryl stearate. The speed of a sterilizing agent entering the device can be limited, the spores are dry in a suspension added with a stable protective agent, the capability of resisting general environmental changes is very good, and the performance of the device can be maintained for a long time.

The invention relates to the field of inorganic material preparation, and particularly discloses pseudo-boehmite and a preparation method thereof. A preparation method of pseudo-boehmite comprises the following steps: (1) mixing an aluminum salt solution and an aluminate solution, adding a crystal form regulating agent, and stirring for reaction to obtain a sol system; the crystal form regulating agent is ZnS quantum dots modified by thiohydracrylic acid; (2) adding a pore diameter guiding agent into the sol system, and aging for 6-8 hours; the pore diameter guiding agent is a compound of a polyethylene glycol-polypropylene glycol-polyethylene glycol triblock copolymer and sodium citrate; and (3) carrying out solid-liquid separation on the aged sol system, and washing and drying the obtained solid to obtain the pseudo-boehmite. The proportion of 5-10nm pores of the pseudo-boehmite prepared by the preparation method disclosed by the invention reaches 90% or above, so that the pore distribution requirement of a fine catalytic reaction on the pseudo-boehmite can be met, and the efficient catalytic reaction is favorably realized.

The invention relates to a doxepin hydrochloride tablet. The doxepin hydrochloride tablet is prepared from doxepin hydrochloride, polyethylene glycol 6000, a filling agent, a disintegrating agent, a flow aid and a lubricating agent. The preparation method comprises the following steps: heating and melting polyethylene glycol 6000, adding a doxepin hydrochloride raw material according to a prescription proportion, and uniformly stirring and mixing; and after complete melting, rapidly cooling and solidifying to form a solid dispersion. And after curing, drying in a drying oven, crushing and sieving. And uniformly mixing the crushed particles with the filler and the lubricant, and directly tabletting. The doxepin hydrochloride has high hygroscopicity, is unstable to damp and heat and easily generates a large amount of impurities under strong oxidation conditions, the doxepin hydrochloride is firstly prepared into a solid dispersion and then is directly compressed, so that the medicine is highly dispersed in a carrier material in the states of molecules, colloids, amorphous forms, microcrystals and the like, and the effect of wrapping the medicine is achieved by controlling the ratio of the medicine to the carrier. Direct contact between the medicine and air is avoided, so that the problems of hygroscopicity and instability of the medicine are solved, and the product stability is improved.

The invention provides a special fiber material and a preparation method thereof, and belongs to the technical field of polymer composites.The preparation method comprises the following steps that cellulose and an ethanol solution are mixed, polyvinyl alcohol and a 3-glycidoxypropyltrimethoxysilane solution are added, the pH is adjusted to be acidic, heating, suction filtration and drying are conducted, and modified cellulose is obtained; mixing expanded graphite, deionized water, ammonium persulfate and dilute sulphuric acid, heating, cooling, dropwise adding amino polyethylene glycol silane, heating, washing and drying to obtain modified expanded graphite; the preparation method comprises the following steps: mixing modified cellulose, modified expanded graphite, phosphate montmorillonite, 3-(methacryloyloxy) propyltrimethoxysilane, bisphenol A diglycidyl ether and 2-methylimidazole, stirring, heating, defoaming, and carrying out two-stage constant-temperature treatment to obtain the special fiber material. The special fiber material disclosed by the invention has good flame retardance, mechanical strength, water resistance and filtering performance, and can be applied to various organic composite boards, filter membranes and the like with high quality requirements.

The invention relates to the field of molecular biology, and discloses a nucleic acid releasing agent for isothermal amplification and a use method of the nucleic acid releasing agent. Comprising the following steps: step 1, preparing a polyoxypropylene polyoxyethylene copolymer diluent, a defoaming agent SE-15 diluent, an ethyl phenyl polyethylene glycol NP-40 diluent, a sodium polyethylene sulfonate diluent and a Proclin300 diluent in sequence through RNA enzyme-free water; and 2, sequentially preparing an ethylenediamine tetraacetic acid disodium salt mother solution, a sodium dodecyl sulfate mother solution and a glycine mother solution through RNA enzyme-free water. Sodium polyethylene sulfonate can be specifically combined with protein amplification inhibitors in a sample to remove mucoprotein, hemoglobin, polysaccharide and other inhibitors in the swab sample, and disodium ethylene diamine tetraacetate can chelate metal ions to reduce the influence of nuclease on target nucleic acid.

The present disclosure provides a hydrogel composition for tissue engineering and regenerative medicine, including naturally derived polymers functionalized with furan groups and nanoparticles of poly(lactic-co-glycolic acid)-poly(ethylene glycol) copolymer functionalized with maleimide groups. Covalent crosslinking via a bioorthogonal Diels-Alder click reaction forms a tunable, biocompatible, and biodegradable three-dimensional network. The hydrogel composition mimics the extracellular matrix and offers adjustable mechanical properties, controlled biodegradation, and therapeutic agent delivery for applications such as cartilage regeneration and drug delivery.

An orally dissolvable or chewable tableted powder formulation is presented. The formulation includes one or more carrier systems including one or more liquid or solid self-emulsifying systems loaded with cannabinoids in an amount of at least 10% by weight of the tableted powder formulation. The one or more self-emulsifying systems includes: at least one or more surfactants, one or more lipids and one or more isolated or synthetic cannabinoids when self-emulsifying system is a liquid self-emulsifying system, and at least one or more surfactants, one or more waxes and one or more isolated or synthetic cannabinoids when self-emulsifying system is a solid self-emulsifying system. The formulation further includes one or more water-soluble agents in an amount of 20-80% by weight of the tableted powder formulation and one or more flavors. The one or more surfactants includes one or more surfactants having a chemical structure that includes a polyethylene glycol moiety.

The invention relates to a high-efficiency low-toxicity fireproof heat-insulation composite coating and a preparation method thereof, and the preparation raw materials of the high-efficiency low-toxicity fireproof heat-insulation composite coating comprise the following components in parts by weight: 20-30 parts of modified polysiloxane, 15-25 parts of ammonium polyphosphate, 8-15 parts of melamine, 15-28 parts of an inorganic filler, 10-15 parts of water, 5-10 parts of a cosolvent, and 1-3 parts of a functional auxiliary agent. The modified polysiloxane is an A-B-C type three-section type block copolymer, wherein the A section is a polydimethylsiloxane or methyl phenyl siloxane block; the segment B is an organic silicon chain segment containing a phosphazene structural unit; and the segment C is a polyethylene glycol or polyoxyethylene block. According to the invention, the modified polysiloxane is cooperated with the ammonium polyphosphate salt and the melamine, so that the composite coating has the effects of high-efficiency fire prevention and heat insulation, low toxicity, environment friendliness and excellent film forming performance.

The application discloses a hydrogel kit capable of quick dissolution on demand, comprising a gel system and a dissolving solution, and the volume ratio of the gel system to the dissolving solution is 1:(2-10). The aldehyde group-terminated star-shaped multi-arm polyethylene glycol gel system and the dissolving solution of the water-soluble amino compound jointly act, so that the gel can be quickly degraded, the gel degradation is realized within half an hour, and the problem that inflammation is caused to the body after the gel is completed is avoided. Moreover, the pH of the water-soluble amino compound dissolving solution is controlled to be 3-7.5, the low-temperature quick degradation of the gel system can be realized, and the degradation time is controlled to be less than 30 min. The application range of the gel is greatly widened, and the long-term foreign body stimulation side effect on patients is reduced.

The invention relates to the technical field of pharmaceutical preparations, and discloses a high-drug-loading risperidone sustained release microsphere for subcutaneous injection and a preparation method thereof, and the preparation method comprises the following steps: mixing risperidone, polylactic acid and dichloromethane to obtain an oil phase; dissolving a pore-forming agent in water to obtain a pore-forming agent solution; mixing polyvinyl alcohol, sodium chloride and water to obtain a water phase; mixing the oil phase with the pore-forming agent solution to obtain primary emulsion; mixing and stirring the primary emulsion and a water phase until dichloromethane is completely volatilized to obtain microspheres loaded with speridone; mixing cellulose acetate, polyethylene glycol and an organic solvent to obtain a coating solution; and coating the risperidone-loaded microspheres with a coating solution to obtain the high-drug-loading risperidone sustained-release microspheres capable of being used for subcutaneous injection. According to the invention, the efficient drug loading is realized, the injection comfort is improved, the slow permeation and release of the drug are realized, and the onset speed and the long-acting treatment demand are balanced.

The application relates to the technical field of cough-relieving medicines, and discloses a high-efficiency cough-relieving loquat particle composition which is composed of the following components in parts by weight: loquat leaf extract 30-40 parts; white front extract 10-15 parts; platycodon grandiflorum extract 6-10 parts; white mulberry bark extract 18-25 parts; stemona sessiliflora extract 7-10 parts; menthol 0.1-0.5 part; polyethylene glycol 2-5 parts; mannitol 8-12 parts; ethyl cellulose 3-6 parts; hydroxypropyl methyl cellulose 1-3 parts; phosphatidylcholine 1-3 parts; polysorbate 80 1-3 parts; cross-linked sodium carboxymethyl cellulose 4-6 parts; and sucrose 40-60 parts. The double dispersion system combining the immediate-release component and the sustained-release component is adopted, the solubility and the initial release speed of the traditional Chinese medicine extract are remarkably improved through the addition of polyethylene glycol and mannitol, and the technical effect that the drug effect appearing time is remarkably shortened is achieved. Compared with the technical scheme relying on only a single release mode in the prior art, the deficiency that the drug effect is slow and the symptoms of the patient cannot be timely relieved is solved.

The invention relates to the field of pesticides, and particularly discloses a pH-light dual-response nano pesticide and a preparation process thereof. The invention relates to a preparation method of a pH-light dual-response nano insecticide. The preparation method comprises the following steps: adding water into polyethylene glycol, castor oil polyoxyethylene ether and sodium lignin sulfonate to prepare a water phase; the preparation method comprises the following steps: uniformly mixing an efficient cyhalothrin active compound with xylene, and adding diisocyanate to prepare an oil phase; adding the oil phase into the water phase, and adding ethylenediamine, YUS-SC3A, glycerol, xanthan gum, magnesium aluminum silicate and benzoic acid to obtain the lambda-cyhalothrin microcapsule suspending agent. The preparation method comprises the following steps: adding water into YUS-SC3A, uniformly mixing, and adding a clothianidin active compound, glycerol, xanthan gum, magnesium aluminum silicate, AF205 and benzoic acid to obtain a clothianidin suspending agent; mixing the two agents to obtain the nano insecticide, adding the composite dispersant, adding the pre-gel, adding azodiisobutyronitrile, blowing with inert gas, and adding Kathon. By preparing the pH-light dual-response nano insecticide, the insecticidal effect is improved, the generation of drug resistance is avoided, and efficient prevention and control of wheat aphids are realized.

The invention discloses a degradable antibacterial anti-inflammatory polyurethane sponge and a preparation method thereof. The preparation method of the polyurethane sponge comprises the following steps: preparing caprolactone / lactide copolymer diol by taking epsilon-caprolactone, DL-lactide and 1, 4-butanediol as raw materials under the action of an organic zinc catalyst ZCAT-T50, and then preparing the polyurethane sponge by taking polyethylene glycol and the caprolactone / lactide copolymer diol as raw materials and 4, 4 '-dicyclohexylmethane diisocyanate as a cross-linking agent under the action of the organic zinc catalyst ZCAT-T50. And finally, sequentially adding an organic zinc catalyst ZCAT-T50, a chitosan oligosaccharide emulsion and a budesonide ethanol solution into the polyurethane prepolymer, and carrying out chain extension, foaming and curing, so as to prepare the budesonide-modified polyurethane composite material. The polyurethane sponge prepared by the invention has excellent mechanical properties, degradability and antibacterial and anti-inflammatory properties, is suitable for making medical hemostatic sponge, and has remarkable economic value and social benefit.

The application discloses a cysteine-rich protein 61 antigen storage solution, which comprises a protein protective agent, a non-ionic surfactant, a preservative, a soluble metal salt, a sugar substance and a buffer solution, wherein the buffer solution is a citric acid-citrate buffer solution, and the storage solution further comprises polyethylene glycol and polyvinylpyrrolidone; the pH value of the storage solution is in the range of 5.0-5.5; the added mass of the polyvinylpyrrolidone is 1.0-1.5 times of the mass of the polyethylene glycol; and the protein protective agent at least contains serum. The storage solution can stably store the cysteine-rich protein 61 antigen, and the cysteine-rich protein 61 antigen can be stably stored for 12 months at 2-8 DEG C and for 7 days at 37 DEG C, thereby solving the inconvenience caused by the freeze-drying storage of Cyr61 protein due to the stability and providing important support for Cyr61 as a new marker for subsequent clinical application.

The invention relates to the field of skin care products, and discloses an unsaturated silanol composition and application thereof in skin care, the composition comprises organosilanol, plant essential oil microcapsules, glycerin, hyaluronic acid, caprylic / capric polyethylene glycol glyceride and purified water; the general formula of the organosilanol is X-Si (OH) 2-Y; wherein: X is a vinyl group, an allyl group, a linear or branched C1-C4 alkyl group; y is a vinyl group, an allyl group,-OCH3,-OCH2CH3,-OCH2OH,-OCH2CH2OH, a linear or branched C1-C4 alkyl group; the plant essential oil microcapsule is prepared by using modified agar prepared by reacting octenyl succinic anhydride with agar, modified beta-cyclodextrin prepared by grafting mono-6-p-toluenesulfonyl-beta-cyclodextrin with chitosan and sodium alginate as wall materials, plant essential oil as a core material and calcium chloride as a cross-linking agent through an extrusion method and a freeze-drying method. And the composition with good antibacterial and antiseptic capabilities, skin barrier reparability and moisturizing and water locking effects is prepared.

The application belongs to the technical field of bioactive nanomaterials, and particularly relates to a metformin nanomaterial, a preparation method and application thereof. The average hydrodynamic diameter of the nanomaterial is less than 500 nm, and the nanomaterial is prepared by a preparation method comprising the following steps: self-assembly of metformin and polyphenols to obtain metformin-polyphenol nanoparticles; reaction of bisphosphonate and polyethylene glycol to obtain bisphosphonate-polyethylene glycol organic segments; and reaction of the metformin-polyphenol nanoparticles and the bisphosphonate-polyethylene glycol organic segments to obtain the nanomaterial. The metformin, polyphenol, polyethylene glycol and bisphosphonate are prepared into the metformin-loaded nanomaterial through specific reactions, the systemic delivery of metformin is realized, the efficacy and bioavailability of metformin on osteoporosis are improved, and the bone targeting of metformin is also improved.

The invention discloses a mineralization repair type oral cavity and throat nursing material for middle-aged and elderly people and a preparation method thereof. The nursing material consists of a core mineralization precursor, a function relieving component and an auxiliary synergistic component, wherein the core mineralization precursor is a biocompatible mineralization matrix of modified hydroxyapatite loaded carbon nitride quantum dots, and is used for realizing mucous membrane mineralization repair; the functional soothing component is a mixture of dihydromyricetin, a licorice extract and a menthol-beta-cyclodextrin inclusion compound, and has mild soothing and anti-inflammatory effects; the auxiliary synergistic component is a mixture of bovine serum albumin and a gamma-polyglutamic acid-g-methoxypolyethylene glycol derivative, and a mineralized precursor is stabilized and mucous membrane adhesion is enhanced by constructing a protein nanocage structure. By optimizing the process, the production efficiency and stability are improved, the biological safety is enhanced, the nursing requirements of middle-aged and elderly oral cavity and throat sensitive mucous membranes are better met, and the oral cavity and throat sensitive mucous membrane repairing gel is suitable for oral cavity mucous membrane sensitive repairing and chronic pharyngitis auxiliary nursing.

The present application provides compositions and methods for treatment of ocular inflammatory conditions, dry eye diseases, and abnormal corneal neovascularization, using etiprednol. In one example, a composition is provided comprising a semi-fluorinated alkane compound such as, e.g., perfluorohexyloctane; and an additive selected from paraffin, propylene glycol diacetate (PGD), a hydroxyalkyl ester of an aliphatic fatty acid, a hydroxyacid alkyl ester, an alkyl ester of a fatty acid, phenethyl alcohol, ethanol, isopropanol, glycerol, propylene glycol, polyethylene glycol, n-butanol, or combinations thereof. Eye drops comprising the compositions are also provided. Methods of using the compositions are also provided and include methods for reducing one or more symptoms of ocular inflammatory conditions, dry eye diseases, or abnormal corneal neovascularization.

The present application relates to a kind of preparation method of cold-proof anti-freezing breathable polyvinyl alcohol hydrogel film, including the preparation of hydrogel precursor solution and the preparation steps of polyvinyl alcohol hydrogel film.The present application also provides the cold-proof anti-freezing breathable polyvinyl alcohol hydrogel film obtained by the preparation method and the application of the film in the field of medical and skin care instruments.The present application is the porous structure of polyvinyl alcohol film prepared by repeated freeze-thaw, ice template method in the ternary solvent system of polyethylene glycol / ethylene glycol / water, the pore size thereof can be controlled by the method of the present application, and the obtained film has good air permeability and biocompatibility, and can be used as covering film in low-temperature surgery, medical dressing, air-permeable protective mask and other scenes.

An orally dissolvable or chewable tableted powder formulation is presented. The formulation includes one or more carrier systems including one or more liquid or solid self-emulsifying systems loaded with cannabinoids in an amount of at least 10% by weight of the tableted powder formulation. The one or more self-emulsifying systems includes: at least one or more surfactants, one or more lipids and one or more isolated or synthetic cannabinoids when self-emulsifying system is a liquid self-emulsifying system, and at least one or more surfactants, one or more waxes and one or more isolated or synthetic cannabinoids when self-emulsifying system is a solid self-emulsifying system. The formulation further includes one or more water-soluble agents in an amount of 20-80% by weight of the tableted powder formulation and one or more flavors. The one or more surfactants includes one or more surfactants having a chemical structure that includes a polyethylene glycol moiety.

The present disclose relates to a high-reactivity hydrogel particle and preparation method therefor and use thereof. The preparation method comprises the following steps: (1) performing polymerization reaction of double-bond modified polyethylene glycol, a modified natural polymer and an optional active functional monomer to obtain a gel; (2) smashing the gel to obtain a gel particle; and (3) performing enzymolysis reaction of the gel particle and an enzyme to obtain the hydrogel particle with reactivity. The double-bond modified polyethylene glycol has a double bond and a polyethylene glycol chain segment, the modified natural polymer has sulfydryl or a double bond, the active functional monomer is selected from a sulfydryl functionalized biological adhesive peptide or sulfydryl functionalized cholesterol, and the enzyme is an enzyme corresponding to the natural polymer. The obtained hydrogel particle has high reactivity and can be used for subsequent secondary crosslinking. The hydrogel particle also has good biocompatibility.

The present application relates to the field of detergent, disclose a kind of weak acid low foam liquid detergent composition, total active content is 15~30wt%, including the following ingredients: modified oil ethoxylate sulfonate 5~15wt%, fatty alcohol polyether type nonionic surfactant 4~8wt%, thickening agent polyethylene glycol double fatty acid ester 0.5~2.0wt%, long chain fatty acid 0.5~1.5wt%, base neutralizer, other auxiliary 0~10wt%, solvent.The liquid detergent composition of the present application is weakly acidic, therefore has lower irritation, more skin-friendly, not hurt hand characteristics, on this basis, the liquid detergent composition of the present application also successfully realizes that fatty acid is introduced into weakly acidic system, and modified oil ethoxylate sulfonate is introduced into weakly acidic system without reducing the viscosity of system, so that weakly acidic liquid detergent composition has low foam specific and ideal viscosity.

The invention discloses a method for preparing a water-based antioxidant emulsion, which comprises the following steps: (1) mixing an effective component and hydrophilic polyether modified silicone oil, stirring and ball-milling at normal temperature, adding polyethylene glycol, and homogenizing at high speed at normal temperature to form a uniform mixed system; (2) stirring and mixing the mixed system, fatty alcohol-polyoxyethylene ether and water, performing three-stage high-pressure homogenization at normal temperature, adding cocamidopropyl betaine, and performing constant-pressure high-pressure homogenization at normal temperature to obtain a water-based antioxidant emulsion; wherein the effective component is one or more of an antioxidant, an ultraviolet light absorber or a light stabilizer. According to the method for preparing the water-based antioxidant emulsion, the water-based antioxidant emulsion has applicable particle size and good particle size distribution and is good in dispersion uniformity and stability; the preparation method is simple and wide in applicability.

The invention discloses a cholesterol modified double-stranded DNA membrane skeleton liposome delivery system and a preparation method and application thereof, and belongs to the technical field of drug delivery. The system is composed of cholesterol, distearoyl phosphatidylcholine, distearoyl phosphatidyl ethanolamine modified by methoxy polyethylene glycol and double-stranded DNA (chol-dsDNA) modified by 5 '-cholesterol, and the chol-dsDNA is anchored on the inner side and the outer side of a liposome membrane through a hydrophobic effect to form a bionic skeleton. The system is excellent in mechanical stability, low in drug leakage rate, high in tumor targeted enrichment capacity and good in biocompatibility, can efficiently entrap irinotecan hydrochloride and other hydrophilic drugs, is used for tumor treatment, and is simple and convenient to prepare and easy to scale.

The application relates to the field of triple-negative breast cancer treatment and relates to synthesis of an acid-responsive amphiphilic liposome and application of the acid-responsive amphiphilic liposome in tumor treatment. A chemotherapeutic drug, a phospholipid, cholesterol and a polyethylene glycolized lipid are dissolved in an organic solvent chloroform, vacuum rotary evaporation is carried out under certain temperature and rotation rate, a water phase is added for hydration, a polypeptide nanogold cluster solution is added for ultrasonic treatment, then crushing, molecular sieve screening, dialysis and ultrafiltration are carried out to obtain a pH-sensitive liposome; in the preparation process, the phospholipid spontaneously forms a kind of biological membrane-like phospholipid bilayer membrane vesicle in water, and the chemotherapeutic drug and the nanogold cluster are wrapped in the vesicle. The pH-sensitive liposome can target the triple-negative breast cancer tumor site through pH response, can improve the solubility of the chemotherapeutic drug, can realize high-efficiency treatment effect of the drug at a low dose, can obviously reduce the toxic side effect of the chemotherapeutic drug, and can realize effective treatment of the triple-negative breast cancer.

The invention provides a cardiac targeting nano drug delivery carrier based on recombinant apolipoprotein, a system, a preparation method and application. The cardiac targeting nano drug delivery carrier comprises a nano carrier core and a functional layer covalently coupled to the surface of the nano carrier core, the nano carrier core comprises an amphiphilic copolymer formed by polylactic acid-glycolic acid and polyethylene glycol; the functional layer comprises recombinant apolipoprotein A-I and heart targeting peptide; the recombinant apolipoprotein A-I contains mutation sites E191A and F225W, and the recombinant apolipoprotein A-I contains mutation sites F225W; the amino acid sequence of the recombinant apolipoprotein A-I is as shown in SEQ ID NO: 1. The cardiac targeting nano drug delivery system based on the recombinant apolipoprotein has the functions of long circulation, cardiac targeting and coordinated regulation and control of metabolism and inflammation, and can be used for precise treatment of chronic heart failure.

The application discloses an acrylic emulsion, and steps are as follows: adding deionized water, polyvinylpyrrolidone and sodium stearate into a reaction kettle under normal temperature, heating, stirring and dissolving, stopping heating after complete dissolution, and obtaining component A; stirring, mixing, heating and obtaining component B by mixing polyethylene glycol, water-based acrylic resin, a dispersing agent and an emulsifier under normal temperature; stirring and mixing water-based color paste, bisphenol A and sodium dodecyl sulfonate under normal temperature, and obtaining component C; stirring and mixing component A, component B and a defoaming agent under normal temperature, heating, cooling again, adding glycerol, cooling, adding essence and component C while stirring, uniformly stirring and mixing, continuously cooling, and obtaining the acrylic emulsion. The obtained acrylic emulsion is environment-friendly, harmless, does not affect children's health, not easy to age, and convenient to clean.

The invention relates to the technical field of freeze-drying preparations, in particular to a plasma protective agent, a freeze-drying method for keeping the pH of plasma and freeze-dried plasma, and the plasma protective agent comprises the following components: an instant protective agent which comprises 5mg / ml of glycine; the feed additive is prepared from sodium dihydrogen phosphate, trehalose, hydroxyethyl starch, polyethylene glycol, mannitol, taurine, tryptophan lysine or glutamic acid. The sustained-release protective agent comprises antioxidant components encapsulated by lipidosome, wherein the antioxidant components comprise glutathione, adenosine and vitamin C. The invention also discloses a preparation method of the sustained-release protective agent. The novel protective agent vitamin C is adopted, the plasma pH adjusting operation is remarkably simplified, and the vitamin C is composed of multiple components with different functions, so that the stability of key components such as blood coagulation factors in plasma is greatly improved.