1435 results about "Polythylene glycol" patented technology

The invention discloses a pharmaceutical composition containing melogabalin besylate and a preparation method of the pharmaceutical composition. Belongs to the technical field of pharmaceutical preparations. Comprising melogabalin besylate and pharmaceutically acceptable auxiliary materials, the pharmaceutically acceptable auxiliary materials comprise a filler, a disintegrating agent, an adhesive, an antioxidant and a lubricant, the antioxidant comprises vitamin E succinic acid polyethylene glycol ester, and the lubricant comprises vitamin E succinic acid polyethylene glycol ester. The melogabalin besylate as the active ingredient accounts for 2-15% by weight of the pharmaceutical composition, preferably 2-10% by weight of the pharmaceutical composition. According to the pharmaceutical composition, antioxidant particles are prepared by adopting a fluidized bed granulation process, raw material medicines, the antioxidant particles and other auxiliary materials are mixed, tableted and coated, an antioxidant comprises vitamin E succinic acid polyethylene glycol ester and tartaric acid, and the prepared tablet has good stability.

The invention provides a preparation method of mitochondria-targeted antioxidant hybrid vesicles. The preparation method comprises the following steps: S1, preparing and separating adipose-derived stem cell nano-vesicles; s2, preparing a liposome loaded with dihydromyricetin and distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000-triphenylphosphine targeting peptide by an ethanol injection method; and S3, preparing the hybrid nano vesicles loaded with the dihydromyricetin and the distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000-triphenylphosphine targeting peptide. The invention also provides the hybrid vesicles prepared by the method and application of the hybrid vesicles in preparation of refractory diabetes wound treatment drugs. The lipidosome and the adipose-derived stem cell nano-vesicles are hybridized to prepare the hybridized vesicles capable of targeting mitochondria and resisting oxidation, the hybridized vesicles are applied to wound treatment for the first time, the problem of oxidative stress of diabetic wounds is solved, wound healing is accelerated, and a new strategy is provided for optimizing mitochondrial function defects and oxidative stress of the diabetic wounds.

The invention discloses an oral care desensitization paste and a preparation method thereof, and mainly relates to the technical field of dental medicines. The oral care desensitization cream is prepared from the following components: bioactive glass, strontium chloride, sodium chloride, silicon dioxide, sodium carboxymethyl cellulose, polyethylene glycol 400, a xanthan gum solution, sodium lauryl sulfate, sodium lauroyl sarcosinate, titanium dioxide, beta-glucan, saccharin sodium salt, sorbitol, methylparaben, propyl hydroxybenzoate, edible essence and water. Compared with the prior art, the oral care desensitization paste disclosed by the invention can be used for sealing dentinal tubules and treating hemodia; the traditional Chinese medicine composition can also be used for treating plaque gingivitis, relieving and reducing gingival bleeding and inhibiting and reducing dental plaque; and meanwhile, the condition of mistakenly swallowing and eating in the using process is reduced.

The invention discloses a polyethylene glycol-poly (2-vinyl) ethylene glycol copolymer and a preparation method thereof, and relates to the technical field of high polymer materials, and the structure of the polyethylene glycol-poly (2-vinyl) ethylene glycol copolymer is selected from any one of the following structural formulas: # imgabs0. The preparation method comprises the following steps: taking hydroxyl-containing polyethylene glycol and 4-vinyl-1, 3-dioxocyclopent-2-ketone or vinyl ethylene oxide as raw materials; under the action of a palladium catalyst and a phosphine ligand, the polyethylene glycol-poly (2-vinyl) glycol copolymer is efficiently prepared and can be used in the fields of hydrophilic / hydrophobic materials, drug carriers, antibacterial materials, phase change materials, shape memory materials and the like.

The invention discloses an antibacterial moisture-absorption softening agent and a preparation method thereof. The preparation method comprises the following preparation steps: 1, preparing a softener; the preparation method comprises the following steps: S1, reacting toluene diisocynate with polyethylene glycol in a solvent to generate an intermediate I; s2, reacting the intermediate I with tetramethyldipropylenetriamine in an inert gas atmosphere to generate an intermediate II; s3, carrying out reaction on the hydrogen-containing silicone oil, allyl polyoxyethylene ether and allyl epoxy terminated polyoxyethylene ether in a solvent and a catalyst to generate modified silicone oil; and S4, carrying out a reaction on the modified silicone oil and a norfloxacin aqueous solution in a solvent, then adding the intermediate II into a reactant, carrying out a reaction for a period of time, and removing impurities to obtain the antibacterial moisture-absorption softening agent.

The invention relates to the technical field of fibers, and discloses an antibacterial and antistatic fiber material based on silver ions and halamine and a preparation method of the antibacterial and antistatic fiber material. The preparation method comprises the following steps: loading a methyl methacrylate-based polymer on the surface of a silver-loaded molecular sieve through an in-situ polymerization method, and grafting a halamine antibacterial monomer chlorinated piperidinol through an ester exchange reaction to obtain an antibacterial agent; the preparation method comprises the following steps: carrying out reaction polymerization on caprolactam, quaternized polyether, polyethylene glycol, 2, 6-dipicolinic acid and adipic acid to obtain an antistatic agent; an antibacterial agent, an antistatic agent and nano-silver are added into chemical fiber slices, the antibacterial and antistatic fiber material based on silver ions and halamine is prepared after melt spinning, and the chemical fiber slices are polyester slices or chinlon slices or polypropylene slices. The fiber material has excellent antibacterial and antistatic properties.

The invention relates to the technical field of inorganic non-metallic materials, in particular to a quaternized cholic acid polyurethane modified polyvinyl chloride material, a preparation method and application. The quaternized cholic acid polyurethane polymer is based on a polyurethane elastomer developed by using cholic acid molecules with a rigid skeleton as a hard segment unit and flexible oligomeric ethylene glycol as a soft segment unit, hydroxyl on cholic acid polyurethane is quaternized to prepare cation modified cholic acid polyurethane, and the cation modified cholic acid polyurethane simulates amphiphilic characteristics of natural peptides. The quaternized cholic acid polyurethane is introduced into a polyvinyl chloride (PVC) matrix as an antibacterial agent, so that the growth of microorganisms such as bacteria and molds can be effectively inhibited, the antibacterial property is achieved, bacteria breeding on the inner surface of a pipeline is avoided, and the composite material is endowed with better biocompatibility and antibacterial property; meanwhile, the quaternized cholic acid polyurethane can effectively improve the strength and toughness of the PVC material; wide application prospects are realized.

The invention provides a polyether ester defoaming agent and a preparation method thereof. Firstly, glycidyl ether and short-chain alcohol react to prepare polyether, and finally, fatty acid is used for blocking to prepare polyether ester 1 #; glycidyl ether, polyethylene glycol and / or polypropylene glycol react to prepare polyether, and finally fatty acid is used for blocking to prepare polyether ester 2 #; glycidol ether, short-chain alcohol, polyethylene glycol and / or polypropylene glycol react to prepare polyether, unsaturated fatty acid continues to be used for blocking to obtain polyether ester, the polyether ester and hydrogen-containing silicone oil continue to react to obtain branched silicon polyether 3 #, and the two polyether esters and the branched silicon polyether are compounded and cooperated to form the final polyether ester defoaming agent. The polyether ester 1 #, the polyether ester 2 # and the branched silicon polyether 3 # all have hyperbranched structures, the polyether ester 1 # improves the dispersing performance and the instant defoaming performance of the defoaming agent, the polyether ester 2 # and the branched silicon polyether 3 # improve the foam inhibition performance of the defoaming agent, and the three substances are compounded to form the stable polyether ester defoaming agent with both defoaming and foam inhibition performance.

The invention relates to the technical field of dispersing agents for ceramics, and discloses a preparation method of a dispersing agent for ceramics, and the novel dispersing agent for ceramics is prepared by taking methoxypolyethylene glycol, bromoacetyl bromide, 4-hydroxyphthalic anhydride, 2, 4, 6-diethanolamine amino-1, 3, 5-s-triazine and the like as raw materials. The polyether polyol contains a plurality of carboxyl groups, has strong interaction with the surface of ceramic powder such as aluminum oxide, has a star-shaped multi-arm polyether molecular chain, can well coat the aluminum oxide powder, can effectively inhibit the growth of crystal nucleus particle size of the aluminum oxide powder, reduces the particle size of the aluminum oxide, and avoids agglomeration and sedimentation of the aluminum oxide; the modified aluminum oxide ceramic powder has good activation degree in solvents such as water, ethanol, dichloromethane or N, N-dimethylformamide and the like, is lower in settling volume and shows excellent dispersing performance.

The invention belongs to the technical field of veterinary preparations, and particularly relates to a tilmicosin premix and a preparation method thereof. The tilmicosin premix is prepared from the following raw materials: tilmicosin, a polylactic acid-glycolic acid copolymer, lecithin, modified hydroxypropyl methyl cellulose, grafted polyvinylpyrrolidone, polyethylene glycol and an antioxidant, a solid dispersion is formed through lecithin and grafted polyvinylpyrrolidone, the solubility and stability of tilmicosin are enhanced, polylactic acid-glycolic acid copolymer nano-microspheres are prepared through a double-emulsion solvent evaporation method, slow release of drugs is achieved, dodecyl modified hydroxypropyl methyl cellulose and polyethylene glycol are combined, and the sustained release effect is achieved. The solubility and the slow release characteristic are further enhanced. The activity of the granular premix is effectively preserved, and the granular premix is convenient to use and transport.

The invention relates to the technical field of fan shell materials, in particular to an antibacterial PP (polypropylene) fan shell material and a preparation method thereof. The polypropylene composite material is prepared from the following components in parts by weight: 80 to 90 parts of polypropylene composite material, 1 to 3 parts of polyethylene glycol grafted maleic anhydride, 1 to 5 parts of modified lignin, 8 to 15 parts of nano modified montmorillonite, 1 to 4 parts of silver nitrate, 1 to 3 parts of coupling agent KH550, 0.1 to 0.5 part of calcium stearate and 0.3 to 0.6 part of antioxidant, through double modification of lignin and three-step modification of montmorillonite, the dispersity and interface bonding strength of the filler are remarkably improved, the tensile strength of the material is improved by 37% or above, and meanwhile good toughness is kept; a multi-component synergistic system realizes the persistence of the antibacterial performance, and the antibacterial efficiency of 95% or above is still kept after 7 days. Thirdly, through the synergistic effect of the modified lignin and the nano-montmorillonite, the thermal stability of the material is remarkably improved, and the initial degradation temperature is increased by 20-35 DEG C.

The invention discloses a fluralamide moxidectin drop and a preparation method thereof, and relates to the technical field of veterinary drugs. The drop is prepared from the following components in parts by weight: 26 to 26.5 parts of fluralan, 1.32 parts of moxidectin, 0.10 part of butylated hydroxytoluene, 29.5 to 30.5 parts of dimethylacetamide, 19.5 to 20 parts of tetrahydrofuran polyethylene glycol ether, 13 to 13.5 parts of diethyl toluamide, 8.5 to 9.3 parts of acetone and 1.0 to 1.5 parts of ethanol. The invention has the effects of improving the stability, permeability and lasting effect of the medicine.

The invention relates to a synthetic method of an ionic liquid and ZIF-8 composite material, which comprises the following steps: S11, adding 2-methylimidazole and octadecyl guanidine chloride into a polyethylene glycol 400 aqueous solution to obtain a solution I; s12, Zn (NO3) 2.6 H2O is added into a polyethylene glycol 400 aqueous solution, and a solution II is obtained; s13, mixing and stirring the solution I and the solution II for reaction, and centrifugally collecting obtained ZIF-8 nanoparticles; s2, adding the ZIF-8 nanoparticles into a sodium phosphotungstate solution, stirring to disperse the ZIF-8 nanoparticles into a suspension, then adding a dodecyl guanidine chloride aqueous solution into the suspension, and carrying out an ion exchange reaction; and centrifuging after the ion exchange reaction is finished. The invention further relates to application of the synthetic method of the ionic liquid and ZIF-8 composite material, and the ionic liquid and ZIF-8 composite material is used for adsorbing 2, 4-D in water. The preparation method is simple, the ionic liquid and the ZIF-8 composite material have good adsorption performance on 2, 4-D in water, and the 2, 4-D is convenient to desorb and is convenient to recycle.

The invention provides weather-resistant anti-freezing road concrete and a preparation method thereof, and belongs to the technical field of concrete. The concrete comprises the following components: sulphoaluminate cement, Portland cement, silica fume, fly ash, modified granite gravel coarse aggregate, medium sand fine aggregate, silica fume blended fiber, silica fume blended polyacrylonitrile fiber, a composite air entraining agent, a functional modifier, a composite antifreeze agent, pre-absorbent zeolite powder and the like. The preparation method comprises the following steps: modifying granite macadam with Al (H2PO4) 3, SiO2 and methoxypolyethylene glycol triethoxysilane, and modifying with a lithium silicate aqueous solution to obtain the modified granite macadam coarse aggregate. The composite air entraining agent comprises a JRY-Q air entraining agent and sodium alpha-olefin sulfonate. The functional modifier is prepared from gas phase method spherical nano silicon dioxide and nano alpha-Al2O3. The composite antifreeze agent comprises ethylene glycol butyl ether acetate and modified calcium carbonate. The modified calcium carbonate is obtained by sequentially modifying nano calcium carbonate with calcium chloride, a KH-550 silane coupling agent and stearic acid.

The invention discloses a method for preparing a fully degradable hydrophilic / hydrophobic double-layer nanofiber membrane based on an electrostatic spinning method. The preparation method comprises the following steps: selecting a degradable high polymer material, taking hexafluoroisopropanol as a solvent, preparing a hydrophilic layer spinning solution from polylactic acid-glycolic acid copolymer (PLGA), methoxypolyethylene glycol (mPEG) and carbon dots (CDs) with antibacterial and anti-inflammatory characteristics, preparing a hydrophobic layer spinning solution from polycaprolactone (PCL), preparing a hydrophilic layer spinning solution from the hydrophilic layer spinning solution, preparing a hydrophilic layer spinning solution from the hydrophobic layer spinning solution, and preparing a hydrophilic layer spinning solution from the hydrophilic layer spinning solution and the hydrophobic layer spinning solution; and preparing the hydrophilic / hydrophobic double-layer nanofiber membrane by adopting an electrostatic spinning machine. The preparation method is simple, and the prepared double-layer nanofiber membrane is uniform in fiber diameter distribution and good in hydrophilic / hydrophobic layer effect and has a good application prospect in the field of biology.

The invention discloses a production process of a modified p-phenylenediamine rubber anti-aging agent, which comprises the following steps: S1, catalyzing a ring-closure reaction through lipase, and accurately controlling pH by combining a phosphate buffer solution, so that the bonding efficiency of 6PPD and tea polyphenol is remarkably improved, and the release amount of aniline is effectively reduced; s2, carrying out spray drying to obtain EP-TP powder to control the particle morphology; s3, increasing the load rate of the anti-aging agent and effectively inhibiting the migration rate of the anti-aging agent through the pore diameter physical confinement of mesoporous silica and an amination gas phase modification technology, and ensuring uniform dispersion of anti-aging agent particles through the synergistic effect of staged load reaction and a polyethylene glycol dispersant; and S4, the particle morphology is cooperatively controlled through vacuum microwave drying, the dispersion requirement of the rubber mixing technology is met, and the interface bonding strength is improved by combining the staged loading reaction with a polyethylene glycol dispersing agent.

The invention relates to antioxidant gel for wound healing as well as a preparation method and application of the antioxidant gel. The antioxidant gel is prepared from the following components in parts by mass: 0.01 to 20 parts of hyaluronic acid, 0.01 to 20 parts of cysteine and 1 to 50 parts of polyethylene glycol carboxyl activated ester. The cysteine modified hyaluronic acid and the polyethylene glycol carboxyl activated ester are cross-linked to form a hydrogel network, the tissue adhesion capacity of the hyaluronic acid gel is remarkably improved, the antioxidant capacity and the anti-inflammatory capacity are further improved, and the hydrogel material is simple in component, good in biocompatibility, stable in cross-linked network and biosafe.

The invention belongs to the technical field of external medicine compositions, and particularly relates to microsphere type antibacterial gel as well as a preparation method and application thereof. The preparation comprises three parts, namely dextran microspheres wrapped by polyethylene glycol, a mixed antibacterial component and a carbomer mixed solution. The mixed antibacterial component is prepared from thymol, chlorhexidine acetate, cinnamyl aldehyde, citral, gallic acid and nano silver. Glucan is prepared into microspheres by utilizing a micro-fluidic chip technology, antibacterial components are wrapped in the microspheres, then the microspheres are compounded into the microsphere type antibacterial gel, and the gel not only shows excellent antibacterial performance and strong adhesive capacity, but also has a remarkable wound repair promoting effect; the microsphere structure can wrap and mix the antibacterial components and play a role in controlled release of the antibacterial components, so that a novel solution is provided for the medical field of antibacterial gel.

The invention relates to the technical field of medicine formulas, in particular to a fluralamide moxidectin composite drop and a preparation process thereof. The invention relates to a fluralan-moxidectin emulsion which is prepared from the following raw materials in percentage by mass: 26 to 30 percent of fluralan, 1.1 to 1.7 percent of moxidectin, 32 to 36 percent of solvent, 0.1 to 0.3 percent of butylated hydroxytoluene, 10 to 16 percent of polymer carrier and the balance of tetrahydrofuran polyethylene glycol ether. The coexisting drug is stabilized through the core-shell structure polymer carrier, phase separation is prevented, a neutral environment is maintained, long-acting stability is ensured, the transdermal absorption rate is optimized, skin irritation is reduced, and the synergistic drug effect is improved. Meanwhile, the slow release period of the medicine is prolonged, the metabolic interference and accumulated toxicity are reduced, and the dissolution efficiency and the skin mildness are both considered.

The invention discloses a preparation method of a raspberry-derived exosome loaded with neroli essential oil. The preparation method comprises the following steps: preparing raspberry fruits into homogenate; centrifuging, collecting supernate, adjusting the pH value to 4.07.5, standing, and centrifuging again; taking supernate, adjusting the pH value to 7.2-7.4, adding polyethylene glycol, standing, centrifuging, collecting precipitate, and carrying out resuspension dispersion; performing microfiltration to obtain supernate, and combining electrophoresis dialysis and ultrafiltration concentration to obtain the high-purity raspberry exosome. And diluting the exosome, adding the diluted exosome into a dimethyl sulfoxide solution containing neroli essential oil, carrying out water bath stirring, carrying out ultrafiltration centrifugation, and taking a clear liquid to obtain the exosome loaded with the neroli essential oil. Efficient separation and purification of the raspberry exosome are achieved by applying an isoelectric precipitation technology, then the neroli essential oil is wrapped in the exosome, the stability of the essential oil is improved, the action time is prolonged, meanwhile, the neroli essential oil and active ingredients of the exosome generate a synergistic effect, and the antioxidant activity is jointly enhanced.

The invention provides a dry-wet cycle resistant composite soil stabilizer and a preparation method thereof. The curing agent is prepared from the following raw materials in parts by weight: 5 to 10 parts of polyacrylamide, 20 to 30 parts of cyclodextrin star derivative, 5 to 10 parts of polyvinyl alcohol, 5 to 8 parts of inorganic salt, 5 to 8 parts of sodium silicate, 10 to 15 parts of waterborne epoxy resin emulsion, 1 to 3 parts of polyoxypropylene triamine and water; the use amount of the water enables the solid content of the dry-wet cycle resistant composite soil stabilizer to be 25-60wt%; the cyclodextrin star derivative is prepared by carrying out esterification reaction on carboxymethyl-beta-cyclodextrin and methoxypolyethylene glycol according to the molar ratio of carboxyl to hydroxyl of 1: (1.1-1.2) under the action of a base catalyst; and the weight-average molecular weight of polyethylene glycol monomethyl ether is 1000 to 1500 g / mol. A plurality of grafting chains of the cyclodextrin star-shaped derivative disperse expansion and shrinkage stress of soil to different directions in the dry-wet cycle process, so that damage to a molecular structure due to stress concentration is avoided.

The present invention relates to the technical field of plastic recycling, and disclosed are a method for preparing a regenerated resin from PET recyclate and a use thereof. The method comprises the following steps: mixing PET recyclate, a polyol, and a catalyst; carrying out elevated temperature reaction; after cooling, adding a polybasic acid or a polybasic acid anhydride for reaction; and after the reaction is finished, cooling to obtain a regenerated resin. The polyol is selected from at least one of diethylene glycol, tripropylene glycol, and polyethylene glycol; the average functionality of the polybasic acid is greater than 2; and the catalyst is selected from at least two of zinc acetate, manganese acetate, and tetrabutyl titanate. According to the present invention, the regenerated resin is applied to the preparation of water-based ink, so that the water-based ink achieves the same printing performance as acrylic resin ink. In the method of the present invention, no waste is generated during polymerization, achieving a 100% recycling rate for waste plastic. Fossil raw materials are saved, and PET recyclate is also fully utilized, achieving the objective of turning waste into wealth.

The invention discloses a C6 monomer polycarboxylate superplasticizer and a preparation method thereof. The C6 monomer polycarboxylate superplasticizer is prepared from the following raw materials in parts by mass: 300-380 parts of C6 ethylene glycol monovinyl polyglycol ether polyether macromonomer, 7.5-11.0 parts of acrylic acid, 0.3-1 part of chain transfer agent, 0.15-1.0 part of reducing agent and 0.6-1.2 parts of oxidizing agent. The water reducing agent prepared by the invention has the advantages of simple process, energy conservation, environmental protection, shortened synthesis time, improved production efficiency, high adaptability and better water reducing property.

The invention relates to an o / w type high-content composite essential oil nanoemulsion and a preparation method and application thereof.The median particle size of the composite essential oil nanoemulsion is not larger than 45 nm, and the composite essential oil nanoemulsion comprises plant essential oil, polyethylene glycol glycerol ricinoleate with the HLB value being 10-14, a cosolvent, water, vitamin E acetate and ethylene diamine tetraacetic acid disodium salt. The plant essential oil is selected from two or more of carvacrol, cinnamyl aldehyde, capsicum oleoresin and thymol. The compound essential oil nanoemulsion solves the key technical problem of high-content load compound nanoemulsion of various plant essential oils, is beneficial to exerting the synergistic effect of different essential oils, and reduces the addition amount of the essential oils while achieving the same physiological function. Besides, the particle size of the composite essential oil nanoemulsion reaches the nanoscale, the composite essential oil nanoemulsion can form homogeneous-phase clear liquid, can be quickly diffused in a waterline or a water environment, is more beneficial to absorption, has the advantages of good stability and long storage life, and is more competitive in practical application.

The invention discloses a preparation method of a pyromellitic acid-terminated polyethylene glycol monomethyl ether concrete viscosity reducer, and belongs to the technical field of concrete materials and concrete admixtures. The preparation method of the pyromellitic acid-terminated polyethylene glycol monomethyl ether concrete viscosity reducer comprises the following steps: mixing pyromellitic anhydride and polyethylene glycol monomethyl ether, and carrying out esterification reaction to obtain the pyromellitic acid-terminated polyethylene glycol monomethyl ether material. According to the invention, the esterification reaction is a reaction between pyromellitic dianhydride with two anhydrides with strong electron withdrawing effects and methoxypolyethylene glycol with nucleophilic hydroxyl groups; the acid anhydride activity of the first reaction of the pyromellitic dianhydride is higher than that of the second reaction of the pyromellitic dianhydride, so that the pyromellitic dianhydride can generate the monoester product with high selectivity, the reaction efficiency is higher, the chemical stability of the monoester product is good, and fewer byproducts are generated.

In some embodiments of the present disclosure, a solid dispersion is provided, comprising: lurasidone or its pharmaceutically acceptable salt and a carrier. The material of the carrier comprises polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silica, hydroxypropyl methycellulose (HPMC), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose (HPC), povidone, copovidone, ethyl cellulose, polyoxyethylene glycol, hypromellose acetate succinate (HPMCAS), hypromellose phthalate (HPMCP), or a combination thereof.

The invention belongs to the technical field of mineral flotation, and particularly discloses a method for recovering whole-fraction iron lepidolite through combination of multi-stage magnetic separation and synergistic flotation. Comprising a matched compound collecting agent which is composed of sodium dodecenesulfonate, amino acid methyl thiohydracrylate, an amphoteric polyacrylamide polymer, carboxyethylidene diphosphonic acid and polyethylene glycol, and efficient recovery of whole-size-fraction iron lepidolite is achieved by matching with a corresponding magnetic separation-flotation combined process. The compound collecting agent generates static electricity and physical and chemical adsorption on the iron lepidolite through specific groups such as sulfonic acid groups, carboxyl groups, amino groups, acylamino groups and phosphate groups, exerts excellent selectivity and collecting functions, generates a dispersion effect and a chelating flocculation effect on micro-fine-particle iron lepidolite, and well cooperates with multi-stage magnetic separation to recover whole-particle-size iron lepidolite, so that the recovery rate of the whole-particle-size iron lepidolite is increased, and the recovery rate of the whole-particle-size iron lepidolite is increased. And the existing combined beneficiation process of the iron lepidolite is optimized, the cost and the environmental influence are reduced, and technical support is provided for sustainable development of lithium resources.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a melogabalin besylate tablet containing a stabilizer and a preparation method of the melogabalin besylate tablet. The melogaba besylate tablet containing the stabilizer comprises a coating and a tablet core, wherein the tablet core comprises the following components: melogaba besylate, the stabilizer, a disintegrating agent, a lubricating agent and the balance of a filling agent; and the coating is prepared from the following materials: an Intai W100 film coating premixing agent and acrylic resin IV. The filling agent comprises xylitol, pregelatinized starch and maltodextrin in a mass ratio of (3-4): 3: (1-2). The stabilizer is vitamin E succinic acid polyethylene glycol ester. The coating is prepared from the following materials: an Intai W100 film coating premixing agent and acrylic resin IV in a mass ratio of (1-1): (1-2). According to the melogabalin besylate tablet prepared by the invention, the stability and the dissolution performance can be synchronously improved.

The invention relates to polyethylene glycol glycerol ricinoleate granules as well as a preparation method and application thereof. The granules comprise first polyethylene glycol glycerol ricinoleate with an HLB (Hydrophile-Lipophile Balance) value of 17-19, second polyethylene glycol glycerol ricinoleate with an HLB value of 12-14, a carrier and vitamin E acetate. According to the invention, fatty acid and / or hydrogenated vegetable oil are / is taken as a nutritional carrier, and polyethylene glycol glycerol ricinoleate with an HLB value of 12-14 is introduced, so that the dispersity of active ingredients with a high HLB value (17-19) in the carrier is effectively improved, and granulation is facilitated; meanwhile, the vitamin E acetate is added, so that the immunity of animals can be enhanced while the effects of resisting oxidation and prolonging the shelf life of the product are achieved. The granules solve the problems that pure products are not easy to mix, inconvenient to use and the like.

The invention belongs to the technical field of veterinary medicine preparation, and particularly relates to a preparation method of a scutellaria baicalensis stem and leaf extract preparation. The preparation method of the scutellaria baicalensis stem and leaf extract preparation comprises the following steps: performing alcohol extraction on scutellaria baicalensis stems and leaves to obtain an alcohol extract; and uniformly mixing the alcohol extract and the lauryl sodium sulfate / polyethylene glycol-6000 mixture to obtain the scutellaria baicalensis stem and leaf extract preparation. According to the preparation method, lauryl sodium sulfate and polyethylene glycol-6000 are jointly added into a scutellaria baicalensis stem and leaf extract obtained through an alcohol extraction method, and the scutellaria baicalensis stem and leaf extract preparation is prepared from the scutellaria baicalensis stem and leaf extract. Due to the solubilizing characteristic of the lauryl sodium sulfate and the polyethylene glycol-6000, the lauryl sodium sulfate and the polyethylene glycol-6000 are dissolved in water and then gather in water to form micelles, the scutellaria baicalensis stem and leaf extract which is insoluble in water can be wrapped in a micelle core through the method, and the solubility of the scutellaria baicalensis stem and leaf extract is further improved.