2201 results about "Polythylene glycol" patented technology

The present invention provides, among other things, methods for preparing functionalized and other polymers from polymer from polymer alcohols such as poly(ethylene glycol)s. In addition, polymer compositions, conjugates, polymeric reagents, are also provided.

The invention discloses a mono-functionalized polyethylene glycol with a nitrogen atom branched center and its preparation method and biologically-relevant matter. The mono-functionalized polyethylene glycol with a nitrogen atom branched center is shown in the general formula (1). The polyethylene glycol-modified biologically-relevant matter is shown in the general formula (2). X1 and X2 represent alkyl containing 1-20 carbon atoms, n1 and n2 are integers of 2-2000, n3 is an integer of 1-2000, L1, L2 and L3 represent connection groups stably existing under the conditions of light, heat, enzyme, redox, acidic or alkaline condition, R represents a functional group or is in a protected form, D represents a biologically-relevant matter, Z1 represents a connection group, and L4 represents residue formed by a reaction of R and the biologically-relevant matter. The branched polyethylene glycol with the nitrogen atom center can interact with a substrate easily so that the substrate protection based on polyethylene glycol is promoted, the state of the substrate in the human body can be effectively improved and a prospect is wide.

The invention relates to a neutral blockage removing agent composition used for an oil recovery formation in an oilfield. The neutral blockage removing agent composition is prepared from the following raw materials in parts by weight: 30-36 parts of disodium polyepoxysuccinicate, 18-25 parts of sodium gluconate, 2-3 parts of polyethylene glycol, 2-4 parts of triethanolamine, 9-12 parts of ethyl lactate, 7-10 parts of fatty alcohol polyoxyethylene ether sodium sulfate, 8-12 parts of amino acid sodium, 10-15 parts of activated attapulgite, 0.1-0.2 part of vanadium pentoxide, 5-7 parts of lipase, 5-8 parts of sorbitan fatty acid ester, 15-18 parts of P-hydroxy sodium sulfonate, 3-7 parts of tert-butyl hydroperoxide and 0.1-0.3 part of diethylene glycol monolaurate. The neutral blockage removing agent composition has high blockage removing speed, is neutral, is free of corrosion and can quickly dissolve material scales, asphalt sediment scales, carbonate scales, silicate scales and the like generated by an ASP flooding system; waste liquid for blockage removal can be degraded and does not need to be discharged onto the ground to be subjected to sewage treatment, the formation in the oilfield is cleaned to remove the blockage, no corrosion, dead angle, precipitation or secondary well blockage is generated, and the blockage removal time does not exceed 24 hours.

The invention relates to a green preparation method of a slow-release polycarboxylic-acid high-performance water reducing agent, which comprises the following steps: firstly, dissolving unsaturated polyethenoxy ether in water, adding an oxidant solution, and evenly stirring; then, respectively and dropwisely adding a reducer/chain-transfer agent mixed solution and a comonomer solution, and polymerizing; and finally, adding an alkaline regulator to neutralize and age the solution, thereby obtaining the slow-release polycarboxylic-acid high-performance water reducing agent. In the invention, hydrogen on the terminal hydroxyl group of the original unsaturated polyethenoxy ether is substituted by an allyl group containing unsaturated bond, so that the terminal group of methoxypolyethylene glycol is converted from the original active hydroxyl group into the inert methoxy group at present; and thus, the byproducts of the copolymerization product are greatly reduced, and the molecular weight distribution is narrow, so that the synthesized water reducing agent has the advantages of high water reduction rate and slump resistance. The redox system with low activation energy is used for initiating the monomer copolymerization, so that the polymerization can be implemented at normal temperature, thereby implementing the production of the product by a no heat source method, simplifying the production equipment and lowering the energy consumption and cost.

It is an object of the present invention to provide a curable composition capable of forming a heat-resistant cured film which is excellent in surface hardness, is good in flexibility and bending properties, and has strength and flexibility that are compatible with each other, and a cured product (film) of the composition. The curable composition includes a reactive (meth)acrylate polymer (A) having a monomer unit represented by the following formula (1), a polymerization initiator (B) and a reactive monomer(C):

wherein R¹ is a hydrogen atom, a methyl group or an ethyl group, R² is a hydrogen atom or a methyl group, X¹ is a straight-chain or branched hydrocarbon group of 2 to 6 carbon atoms or an alcohol residue of polyethylene glycol, polypropylene glycol or caprolactone-modified both-terminal diol, n is an integer of 2 to 4, and m is an integer of 1 to 5.

Disclosed is a method for preparation of molecular sieve modified by SBA- 15 surface sulfuric acid group, which contains the step: with polymer of the polyethylene glycol- polyglycerol- polyethylene glycol as the template agent, 3-mercaptopropyl-trimethoxysilane condensing ethyl orthosilicate in a acid condition, and by the oxidization of hydroperoxide, the molecular sieve modified by propanesulfonic acid being synthesized. The method for preparation is simple, the operation is easy, and the reaction condition is mild; the acid containing and the structure of the molecular can be regulated and controlled by regulating the matching of materials and processing parameter, the acid quantity being among 0.48- 1.15mmolH+/ g, specific surface being among 445- 680m2/ g, and the pore diameter being among 5.47- 7.58nm.

The invention discloses a preparation method for a high-slump-retention polycarboxylate water reducer. The preparation method comprises the following steps of: esterifying methoxylpolyethylene glycol monomethyl ethers with different molecular weights with methacrylic acid and a mixed polymerization inhibitor for a period of time under the action of a catalyst and at a certain temperature, then adding allyl alcohol in one time, further esterifying in the same conditions to obtain an esterified macromonomer MP containing crosslinking monomer allyl methacrylate; then performing aqueous solution polymerization on the MP, unsaturated sulfonate, (meth)acrylate unsaturated monomers and a chain transfer agent in a low-temperature condition and within a redox initiation system; and finally adding caustic soda liquid to neutralize, so as to obtain the polycarboxylate water reducer with a certain concentration. The high-slump-retention polycarboxylate water reducer prepared by the preparation method disclosed by the invention is a high-performance water reducer which is prepared at a low temperature by virtue of a molecular structure design, as well as is high in slump retention, excellent in dispersing performance, good in adaptability, simple in process, pollution-free, low in energy consumption, and easy to realize industrialized production.

The invention discloses a temperature-sensitive hydrogel based on chemical cross-linking gel granules and a preparation method of the temperature-sensitive hydrogel, belonging to the technical field of macromolecular and biological materials. The hydrogel is a chemical cross-linking nanometre granule water solution with a certain concentration, and chemical cross-linking nanometre granules are uniformly dispersed in the water; the nanometre granules are formed by introducing crosslinkable groups to both ends of segmented copolymer with amphipathicity composed of polyethylene glycol/polyester, dissolving in water according to a certain concentration, spontaneously assembling into micelles and adding an initiator to initiate polymerizing cross-linking. As the temperature rises, the gel granules at a certain concentration can generate solution-gel transition. The multi-scale gel is suitable for being used as a pharmaceutical carrier biological material.

Poly(ethylene glycol) carbamate derivatives useful as water-soluble prodrugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the drug at a controllable rate as the gel degrades.

The present invention discloses the preparation process of microcapsule with included anticancer medicine. The process adopts colloid particle containing polyelectrolyte as template, assembles polyelectrolytes with dislike charges via layer-by-layer self-assembling to the surface of colloid particle, and dissolves or decomposes the colloid particle to obtain hollow polymer microcapsule containing polyelectrolyte. The microcapsule has wall micro structure and thickness capable of being regulated precisely in nanometer size, and the contained polyelectrolyte can interact with the medicine so as to include the medicine into the microcapsule. The included medicine has controllable release speed. Introducing polyelectrolyte with grafted polyglycol to the surface of the microcapsule can raise the biocompatibility of the microcapsule. The process of the present invention is simple, feasible and repeatable, and suitable for inclusion and controllable release of various kinds of water soluble anticancer medicine.

The invention discloses a method for extracting squalene by using camellia oleosa seeds as raw materials and tea oil and squalene soft capsules and relates to the technical field of biomedicine. The extraction method comprises the following process flows of material preparation, grinding, leaching, concentration, methyl esterification, complexant-borax reaction, macroporous resin chromatographic separation and purification, concentration, extraction, washing, concentration, preparation of squalene crude oil and supercritical carbon dioxide extraction, so that squalene essential oil with the squalene content of more than or equal to 80 percent is obtained. The tea oil and squalene soft capsules are prepared from the following raw materials in percentage by weight: 87 to 90 percent of squalene essential oil with the squalene content of more than or equal to 80 percent, 3 to 5 percent of polyethylene glycol 400, 2 to 3 percent of beewax and 2 to 5 percent of phospholipid. The raw material resources are wide. The prepared tea oil and squalene soft capsules not only can be used for medicine, but also can be used for food therapy, are particularly suitable for administration of treatment and food therapy of patients suffering from hepatitis, fatty liver, acute and chronic inflammation, tumor, chemotherapy, diabetes mellitus and cardio-cerebrovascular disease and have no toxic or side effects.

The invention belongs to the field of medical technology, relates to a high-stability polyethylene glycol-polyester polymer and an application thereof, and particularly relates to an amphiphilic block copolymer having a hydrophilic block and a hydrophobic block with terminal hydroxyl, wherein the terminal hydroxyl of the hydrophobic block is replaced by a cholic acid group. The hydrophilic A block is any one of ethylene glycol monomethyl ether, polyethylene glycol, polyvinyl alcohol and polyvinylpyrrolidone; the hydrophobic B block is any one of polylactide, polylactide-co-glycolide, polyglycollide, polycaprolactone, polylactide-co-caprolactone, polyglycollide-co-caprolactone and polylactide-co-glycolide-cocaprolactone. The polymer provided by the invention can spontaneously form high-stability micelle in a waterborne medium, and can be used as a carrier of various water-insoluble drugs.

The present invention is thickener for heat resistant no-harm fracturing fluid and its preparation process and use. The thickener in the general expression of R1-X-(EO)m(PO)n-Y, where, R1 is long chain hydrophobic group, EO is ethoxy group, PO is 2-oxidized propyl group, m and n are average addition molar numbers, X is linking group ether bond, ester bond or amido bond, Y is hydrophilic group quaternary ammonium group, carboxyl group, sulfuric group or sulfonic group, is prepared through esterification or addition and further reaction. When the thickener is applied, the thickener in 1-3 weight portions and high temperature stabilizer in 0.05-0.4 weight portion are added into base fluid compounded with halogen salt in 2-3 weight portions and water in 100 weight portions to obtain heat resistant no-harm fracturing fluid for increasing yield of oil-gas field.

The invention relates to the field of chemical industry, in particular to a crotonic acid system polycarboxylic acid high-performance water reducer. The water reducer is prepared by copolymerizing 60 to 80 mass percent of first monomers, 20 to 40 mass percent of second monomers and 0 to 20 mass percent of third monomers, wherein the first monomers comprise methoxy polyethylene glycol crotonate, methoxy polyethylene glycol mono-crotonate, allylpolyethyleneglycol (APEG) and the like; the second monomers comprise crotonic acid, ethyl crotonate or ethyl crotonate and the like; and the third monomers comprise acrylic acid, methacrylic acid, maleic anhydride, methylmaleic acid, itaconic acid, methyl acrylate, hydroxyethyl acrylate, hydroxy-propyl acrylate, sodium allylsulfonate or acrylamide and the like. a preparation process for the water reducer is simple and low in cost, and the polycarboxylic acid high-performance water reducer with excellent performance can be prepared under the condition of not using high-cost monomers such as methacrylic acid, acrylic acid or 2-acrylamide-2-methylpropanesulfonic acid, sodium methallylsulphonate, sodium allylsulfonate and the like.

The invention discloses a preparation method for a cellulose crystal susceptible to re-dispersion after drying, which comprises selection and using for cellulose crystal materials and non-ionic surface active agents; and a preparing and drying processing method for cellulose crystal suspending liquid materials, wherein the cellulose crystal materials comprise different types of cellulose crystals obtained by different cellulose sources and different processing methods; and the non-ionic surface active agents are APG, poly ethylene glycol, and polypropylene glycol. The preparation method comprises the following steps: mixing and stirring one of the non-ionic surface active agents and one of cellulose crystal suspending liquid to obtain the cellulose crystal suspending liquid materials; the cellulose crystal suspending liquid materials are subjected to drying processing by a fluid bed dryer or a spray dryer to obtain granulated, particulate, or powdered cellulose crystals which can disperse in an aqueous phase system quickly; and obtaining a particle size distribution, which can maintain original properties of the cellulose crystals, is similar to that of the original cellulose crystals after re-dispersing. Therefore, the cellulose crystals capable of re-dispersion provide convenience for the storage, the transportation, and the follow-up application.

The present invention discloses one kind of folic acid acceptor targeting liposome as medicine carrier and its preparation process and application. The liposome has components including synthetic phospholipid, cholesterol, folic acid acceptor targeting anchor point and polyglycol hydrating anchor point. The present invention has relatively simple preparation process, and can prepare liposome of size smaller than 200 nm in large scale and prepare freeze dried powder of weak alkali medicine, including leurocristine, etc. carried on the liposome with greatly raised use convenience and stability. The medicine is re-constructed with bacteria-free water or brine before use, and the medicine leakage rate is lower than 10 %.

The invention relates to a method for recovering silicon carbide and polyethylene glycol cutting fluid from waste silicon wafer cutting fluid. The method is characterized by comprising the following steps: stirring the waste cutting fluid at normal temperature and separating to obtain solid and liquid; adding pure water to the solid, stirring, smashing, adding alkali liquor for reacting, and transferring the obtained reaction product into a centrifugal separator to obtain silicon carbide liquid flow; adding acid liquor for reacting, and then transferring the obtained reaction product into the centrifugal separator to obtain clear silicon carbide liquid flow; cleaning and then transferring the clear silicon carbide liquid flow into a dryer for drying, screening by air classification and packaging; adding a decolorizer and a filter aid to the liquid part after solid-liquid separation, performing mechanical separation, adding the decolorizer and the filter aid again to the separated liquid, performing mechanical separation, filtering and desalinizing with an ion exchange system, and dewatering with a four-effect evaporation system to obtain the polyethylene glycol cutting fluid. The method of the invention can prevent environmental pollution caused by direct emission of the waste silicon wafer cutting fluid and effectively reduce the production cost for cutting silicon wafers.

The invention provides an anticancer intermediate based on PKI-587 and a polyethylene glycol coupled anticancer drug, and preparation methods and application thereof, belonging to the field of treatment of cancers. The anticancer intermediate has a general structural formula as described in the specification, and at least one AC in the general structural formula is the anticancer drug PKI-587. Thepolyethylene glycol coupled anticancer drug has a general structural formula as described in the specification. The above two drugs can realize combined medication of the targeting anticancer drug PKI-587 and a plurality of other anticancer drugs, so toxic response caused by mutual influence and pharmacokinetics of a plurality of other anticancer drugs can be prevented during individual administration of the anticancer drugs, multidrug resistance of cancers is overcome, and synergistic effect is exerted; and the two drugs can be used for preparing anticancer drugs with targeting effect and have critical clinical value and wide market prospects.

A polyethanediol modified trisiloxane containing glucosylamido used as the assistant of agricultural chemical to decrease the surface tension of water is prepared through catalytic reaction between hexamethyldisiloxane and aminosilane to obtain aminotrisiloxane, reacting on lactone gluconate in methanol to obtain trisiloxane containing glucosylamido, and modifying it by polyethanediol method glicideether.

The invention relates to a biocontrol bacterial agent. An effective active constituent consists of bacillus subtilis PTS-394. The biocontrol bacterial agent is characterized in that: the biocontrol bacterial agent is aqueous solution or wettable powder. The aqueous solution comprises the following components in percentage by weight: bacillus subtilis PTS-394 with 2 *1,010 cfu/mL of content of bacteria, 0.5 percent of NNO (sodium methylene naphthalene sulfonate), 6 percent of SDBS (sodium dodecyl benzene sulfonate) and 0.1 percent of sodium benzoate. The wettable powder comprises the following components in percentage by weight: 40 percent of bacillus subtilis PTS-394 viable bacterium raw powder with 5 *1,010 cfu/g of content of bacteria, 7 percent of NNO (sodium methylene naphthalene sulfonate), 3 percent of polyethylene glycol, 5 percent of SDBS (sodium dodecyl benzene sulfonate) and 45 percent of light calcium carbonate. The biocontrol bacterial agent is poured into vegetable roots when applied and is used for preventing and controlling vegetable soil-borne diseases such as solanaceous fruit vegetable blight and bacterial wilt mainly; and the content of effective agent components is between 104 and 108 cfu/mL or between 104 and 108 cfu/g after finished product agents are diluted. The biocontrol bacterial agent has the advantages that: the aims of preventing and controlling two kinds of soil-borne diseases by means of one kind of biocontrol bacterial agent are fulfilled by introducing the bacillus subtilis PTS-394 which is safe to people and livestock and has better inhibition effect on the solanaceous fruit vegetable blight and the bacterial wilt; the using amount of chemical agents is reduced, and the agent cost is reduced; and the ecological environment is improved, and the residues of the chemical agents in the vegetables are reduced and the same time.

Disclosed herein is a temperature- and pH-sensitive block copolymer having excellent gel strength, including: (a) a poly(ethylene glycol)-based compound (A) or a copolymer (B) of the poly(ethylene glycol)-based compound (A) and a biodegradable polymer; and (b) a polyurethane-based oligomer (C). Further, a method of preparing a temperature and pH-sensitive block copolymer having excellent gel strength, including: (a) synthesizing a poly(ethylene glycol)-based compound (A) or a copolymer (B) of the poly(ethylene glycol)-based compound (A) and a biodegradable polymer; and (b) coupling a polyurethane-based oligomer (C) with the copolymer (B), is disclosed. Also disclosed is a polymer hydrogel type drug delivery system, including: (a) the block copolymer; and (b) a physiologically active substance which can be included in the block copolymer.

The invention provides a black phosphorus quantum dot composite material comprising a black phosphorus quantum dot, positive ions modified on the surface of the black phosphorus quantum dot and polyethylene glycol or polyethylene glycol derivatives. The positive ions comprise the metal positive ions or the ammonium ions. The positive ions are combined with the black phosphorus quantum dot through electrostatic force, and the pieces of polyethylene glycol or the polyethylene glycol derivatives are combined with the black phosphorus quantum dot through Van der Waals force. According to the black phosphorus quantum dot composite material, the positive ions are combined with the black phosphorus quantum dot through the electrostatic force, so that the oxidation resistance ability of the positive ions is improved greatly, and the pieces of polyethylene glycol or the polyethylene glycol derivatives are combined with the black phosphorus quantum dot through the Van der Waals force so that the black phosphorus quantum dot can be stably dispersed in water. The invention provides a preparation method of the black phosphorus quantum dot composite material in the second aspect. The method is simple and easy to operate. The black phosphorus quantum dot composite material can be used for preparing photoacoustic imaging drugs, or photothermal therapy drugs, or photodynamic therapy drugs or drug-loading targeted therapy drugs.

The invention relates to the technical field of natural skin care products, in particular to an eaglewood whitening facial cleanser and a preparation method thereof. The eaglewood whitening facial cleanser is composed of the following raw materials by mass: 2-8% of an eaglewood extract, 5-18% of a Chinese herb extract, 2-10% of an aloe extract, 1-1.5% of lecithin, 2-4% of TWEEN 80, 4-8% of compound vitamin, 1-2% of citric acid, 7-15% of pyrrolidone carboxylic acid polyglycol ester, 25-40% of cocamidopropyl betaine (CAB-35), and the balance deionized water. The facial cleanser provided by the invention takes pure natural, fragrant and skin care eaglewood and Chinese herb extracts as active ingredients, the active ingredients are compounded with certain emulsification component lecithin and natural vitamin to prepare the facial cleanser. With the efficacy of whitening skin, lightening pigmentation, removing color spots, and keeping skin moisture, the whitening facial cleanser can kill or inhibit bacteria attached on the skin surface, also can delay aging, and promote epithelium regeneration.