946 results about "Polythylene glycol" patented technology

The invention provides a preparation method of mitochondria-targeted antioxidant hybrid vesicles. The preparation method comprises the following steps: S1, preparing and separating adipose-derived stem cell nano-vesicles; s2, preparing a liposome loaded with dihydromyricetin and distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000-triphenylphosphine targeting peptide by an ethanol injection method; and S3, preparing the hybrid nano vesicles loaded with the dihydromyricetin and the distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000-triphenylphosphine targeting peptide. The invention also provides the hybrid vesicles prepared by the method and application of the hybrid vesicles in preparation of refractory diabetes wound treatment drugs. The lipidosome and the adipose-derived stem cell nano-vesicles are hybridized to prepare the hybridized vesicles capable of targeting mitochondria and resisting oxidation, the hybridized vesicles are applied to wound treatment for the first time, the problem of oxidative stress of diabetic wounds is solved, wound healing is accelerated, and a new strategy is provided for optimizing mitochondrial function defects and oxidative stress of the diabetic wounds.

The invention discloses an oral care desensitization paste and a preparation method thereof, and mainly relates to the technical field of dental medicines. The oral care desensitization cream is prepared from the following components: bioactive glass, strontium chloride, sodium chloride, silicon dioxide, sodium carboxymethyl cellulose, polyethylene glycol 400, a xanthan gum solution, sodium lauryl sulfate, sodium lauroyl sarcosinate, titanium dioxide, beta-glucan, saccharin sodium salt, sorbitol, methylparaben, propyl hydroxybenzoate, edible essence and water. Compared with the prior art, the oral care desensitization paste disclosed by the invention can be used for sealing dentinal tubules and treating hemodia; the traditional Chinese medicine composition can also be used for treating plaque gingivitis, relieving and reducing gingival bleeding and inhibiting and reducing dental plaque; and meanwhile, the condition of mistakenly swallowing and eating in the using process is reduced.

The invention relates to the technical field of inorganic non-metallic materials, in particular to a quaternized cholic acid polyurethane modified polyvinyl chloride material, a preparation method and application. The quaternized cholic acid polyurethane polymer is based on a polyurethane elastomer developed by using cholic acid molecules with a rigid skeleton as a hard segment unit and flexible oligomeric ethylene glycol as a soft segment unit, hydroxyl on cholic acid polyurethane is quaternized to prepare cation modified cholic acid polyurethane, and the cation modified cholic acid polyurethane simulates amphiphilic characteristics of natural peptides. The quaternized cholic acid polyurethane is introduced into a polyvinyl chloride (PVC) matrix as an antibacterial agent, so that the growth of microorganisms such as bacteria and molds can be effectively inhibited, the antibacterial property is achieved, bacteria breeding on the inner surface of a pipeline is avoided, and the composite material is endowed with better biocompatibility and antibacterial property; meanwhile, the quaternized cholic acid polyurethane can effectively improve the strength and toughness of the PVC material; wide application prospects are realized.

The invention discloses a fluralamide moxidectin drop and a preparation method thereof, and relates to the technical field of veterinary drugs. The drop is prepared from the following components in parts by weight: 26 to 26.5 parts of fluralan, 1.32 parts of moxidectin, 0.10 part of butylated hydroxytoluene, 29.5 to 30.5 parts of dimethylacetamide, 19.5 to 20 parts of tetrahydrofuran polyethylene glycol ether, 13 to 13.5 parts of diethyl toluamide, 8.5 to 9.3 parts of acetone and 1.0 to 1.5 parts of ethanol. The invention has the effects of improving the stability, permeability and lasting effect of the medicine.

The invention relates to a synthetic method of an ionic liquid and ZIF-8 composite material, which comprises the following steps: S11, adding 2-methylimidazole and octadecyl guanidine chloride into a polyethylene glycol 400 aqueous solution to obtain a solution I; s12, Zn (NO3) 2.6 H2O is added into a polyethylene glycol 400 aqueous solution, and a solution II is obtained; s13, mixing and stirring the solution I and the solution II for reaction, and centrifugally collecting obtained ZIF-8 nanoparticles; s2, adding the ZIF-8 nanoparticles into a sodium phosphotungstate solution, stirring to disperse the ZIF-8 nanoparticles into a suspension, then adding a dodecyl guanidine chloride aqueous solution into the suspension, and carrying out an ion exchange reaction; and centrifuging after the ion exchange reaction is finished. The invention further relates to application of the synthetic method of the ionic liquid and ZIF-8 composite material, and the ionic liquid and ZIF-8 composite material is used for adsorbing 2, 4-D in water. The preparation method is simple, the ionic liquid and the ZIF-8 composite material have good adsorption performance on 2, 4-D in water, and the 2, 4-D is convenient to desorb and is convenient to recycle.

The invention provides weather-resistant anti-freezing road concrete and a preparation method thereof, and belongs to the technical field of concrete. The concrete comprises the following components: sulphoaluminate cement, Portland cement, silica fume, fly ash, modified granite gravel coarse aggregate, medium sand fine aggregate, silica fume blended fiber, silica fume blended polyacrylonitrile fiber, a composite air entraining agent, a functional modifier, a composite antifreeze agent, pre-absorbent zeolite powder and the like. The preparation method comprises the following steps: modifying granite macadam with Al (H2PO4) 3, SiO2 and methoxypolyethylene glycol triethoxysilane, and modifying with a lithium silicate aqueous solution to obtain the modified granite macadam coarse aggregate. The composite air entraining agent comprises a JRY-Q air entraining agent and sodium alpha-olefin sulfonate. The functional modifier is prepared from gas phase method spherical nano silicon dioxide and nano alpha-Al2O3. The composite antifreeze agent comprises ethylene glycol butyl ether acetate and modified calcium carbonate. The modified calcium carbonate is obtained by sequentially modifying nano calcium carbonate with calcium chloride, a KH-550 silane coupling agent and stearic acid.

The invention discloses a production process of a modified p-phenylenediamine rubber anti-aging agent, which comprises the following steps: S1, catalyzing a ring-closure reaction through lipase, and accurately controlling pH by combining a phosphate buffer solution, so that the bonding efficiency of 6PPD and tea polyphenol is remarkably improved, and the release amount of aniline is effectively reduced; s2, carrying out spray drying to obtain EP-TP powder to control the particle morphology; s3, increasing the load rate of the anti-aging agent and effectively inhibiting the migration rate of the anti-aging agent through the pore diameter physical confinement of mesoporous silica and an amination gas phase modification technology, and ensuring uniform dispersion of anti-aging agent particles through the synergistic effect of staged load reaction and a polyethylene glycol dispersant; and S4, the particle morphology is cooperatively controlled through vacuum microwave drying, the dispersion requirement of the rubber mixing technology is met, and the interface bonding strength is improved by combining the staged loading reaction with a polyethylene glycol dispersing agent.

The invention relates to the technical field of medicine formulas, in particular to a fluralamide moxidectin composite drop and a preparation process thereof. The invention relates to a fluralan-moxidectin emulsion which is prepared from the following raw materials in percentage by mass: 26 to 30 percent of fluralan, 1.1 to 1.7 percent of moxidectin, 32 to 36 percent of solvent, 0.1 to 0.3 percent of butylated hydroxytoluene, 10 to 16 percent of polymer carrier and the balance of tetrahydrofuran polyethylene glycol ether. The coexisting drug is stabilized through the core-shell structure polymer carrier, phase separation is prevented, a neutral environment is maintained, long-acting stability is ensured, the transdermal absorption rate is optimized, skin irritation is reduced, and the synergistic drug effect is improved. Meanwhile, the slow release period of the medicine is prolonged, the metabolic interference and accumulated toxicity are reduced, and the dissolution efficiency and the skin mildness are both considered.

The invention discloses a preparation method of a raspberry-derived exosome loaded with neroli essential oil. The preparation method comprises the following steps: preparing raspberry fruits into homogenate; centrifuging, collecting supernate, adjusting the pH value to 4.07.5, standing, and centrifuging again; taking supernate, adjusting the pH value to 7.2-7.4, adding polyethylene glycol, standing, centrifuging, collecting precipitate, and carrying out resuspension dispersion; performing microfiltration to obtain supernate, and combining electrophoresis dialysis and ultrafiltration concentration to obtain the high-purity raspberry exosome. And diluting the exosome, adding the diluted exosome into a dimethyl sulfoxide solution containing neroli essential oil, carrying out water bath stirring, carrying out ultrafiltration centrifugation, and taking a clear liquid to obtain the exosome loaded with the neroli essential oil. Efficient separation and purification of the raspberry exosome are achieved by applying an isoelectric precipitation technology, then the neroli essential oil is wrapped in the exosome, the stability of the essential oil is improved, the action time is prolonged, meanwhile, the neroli essential oil and active ingredients of the exosome generate a synergistic effect, and the antioxidant activity is jointly enhanced.

The invention discloses a C6 monomer polycarboxylate superplasticizer and a preparation method thereof. The C6 monomer polycarboxylate superplasticizer is prepared from the following raw materials in parts by mass: 300-380 parts of C6 ethylene glycol monovinyl polyglycol ether polyether macromonomer, 7.5-11.0 parts of acrylic acid, 0.3-1 part of chain transfer agent, 0.15-1.0 part of reducing agent and 0.6-1.2 parts of oxidizing agent. The water reducing agent prepared by the invention has the advantages of simple process, energy conservation, environmental protection, shortened synthesis time, improved production efficiency, high adaptability and better water reducing property.

The invention relates to an o / w type high-content composite essential oil nanoemulsion and a preparation method and application thereof.The median particle size of the composite essential oil nanoemulsion is not larger than 45 nm, and the composite essential oil nanoemulsion comprises plant essential oil, polyethylene glycol glycerol ricinoleate with the HLB value being 10-14, a cosolvent, water, vitamin E acetate and ethylene diamine tetraacetic acid disodium salt. The plant essential oil is selected from two or more of carvacrol, cinnamyl aldehyde, capsicum oleoresin and thymol. The compound essential oil nanoemulsion solves the key technical problem of high-content load compound nanoemulsion of various plant essential oils, is beneficial to exerting the synergistic effect of different essential oils, and reduces the addition amount of the essential oils while achieving the same physiological function. Besides, the particle size of the composite essential oil nanoemulsion reaches the nanoscale, the composite essential oil nanoemulsion can form homogeneous-phase clear liquid, can be quickly diffused in a waterline or a water environment, is more beneficial to absorption, has the advantages of good stability and long storage life, and is more competitive in practical application.

The invention belongs to the technical field of mineral flotation, and particularly discloses a method for recovering whole-fraction iron lepidolite through combination of multi-stage magnetic separation and synergistic flotation. Comprising a matched compound collecting agent which is composed of sodium dodecenesulfonate, amino acid methyl thiohydracrylate, an amphoteric polyacrylamide polymer, carboxyethylidene diphosphonic acid and polyethylene glycol, and efficient recovery of whole-size-fraction iron lepidolite is achieved by matching with a corresponding magnetic separation-flotation combined process. The compound collecting agent generates static electricity and physical and chemical adsorption on the iron lepidolite through specific groups such as sulfonic acid groups, carboxyl groups, amino groups, acylamino groups and phosphate groups, exerts excellent selectivity and collecting functions, generates a dispersion effect and a chelating flocculation effect on micro-fine-particle iron lepidolite, and well cooperates with multi-stage magnetic separation to recover whole-particle-size iron lepidolite, so that the recovery rate of the whole-particle-size iron lepidolite is increased, and the recovery rate of the whole-particle-size iron lepidolite is increased. And the existing combined beneficiation process of the iron lepidolite is optimized, the cost and the environmental influence are reduced, and technical support is provided for sustainable development of lithium resources.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a melogabalin besylate tablet containing a stabilizer and a preparation method of the melogabalin besylate tablet. The melogaba besylate tablet containing the stabilizer comprises a coating and a tablet core, wherein the tablet core comprises the following components: melogaba besylate, the stabilizer, a disintegrating agent, a lubricating agent and the balance of a filling agent; and the coating is prepared from the following materials: an Intai W100 film coating premixing agent and acrylic resin IV. The filling agent comprises xylitol, pregelatinized starch and maltodextrin in a mass ratio of (3-4): 3: (1-2). The stabilizer is vitamin E succinic acid polyethylene glycol ester. The coating is prepared from the following materials: an Intai W100 film coating premixing agent and acrylic resin IV in a mass ratio of (1-1): (1-2). According to the melogabalin besylate tablet prepared by the invention, the stability and the dissolution performance can be synchronously improved.

The invention relates to polyethylene glycol glycerol ricinoleate granules as well as a preparation method and application thereof. The granules comprise first polyethylene glycol glycerol ricinoleate with an HLB (Hydrophile-Lipophile Balance) value of 17-19, second polyethylene glycol glycerol ricinoleate with an HLB value of 12-14, a carrier and vitamin E acetate. According to the invention, fatty acid and / or hydrogenated vegetable oil are / is taken as a nutritional carrier, and polyethylene glycol glycerol ricinoleate with an HLB value of 12-14 is introduced, so that the dispersity of active ingredients with a high HLB value (17-19) in the carrier is effectively improved, and granulation is facilitated; meanwhile, the vitamin E acetate is added, so that the immunity of animals can be enhanced while the effects of resisting oxidation and prolonging the shelf life of the product are achieved. The granules solve the problems that pure products are not easy to mix, inconvenient to use and the like.

The invention discloses a hydrogel for gastric perforation repair, which belongs to the field of bioadhesives. The technical scheme is as follows: a hydrogel for gastric perforation repair is generated by chemical reaction of compound A and compound B; compound A is a polyethylene glycol derivative A with a terminal active group α; the terminal active group α is succinimidyl succinate; compound B is a polyethylene glycol derivative B with a terminal active group β; the terminal active group β is an amino group; when compound A reacts with compound B, the terminal active group α and the terminal active group β chemically react to form an amide bond. The beneficial effects of the invention are as follows: the hydrogel for gastric perforation repair provided by the invention has a fast gelation speed, can be gelled in situ, is easy to use, has strong adhesion to gastric tissue, has a low swelling rate in simulated gastric fluid and PBS solution, has a strong ability to resist simulated gastric fluid corrosion, has good compression resistance and anti-peristalsis performance, has good biocompatibility, and can be safely degraded.

The invention discloses a biological challenge device with combined adjustable resistance for evaluating the effect of a sterilization process, which comprises a shell, the shell comprises a plastic pipe and an inner pipe cap detachably connected with the inner wall of the plastic pipe, the inner pipe cap is provided with a breathable window and covered by a breathable film, and a bacterial contamination carrier for bearing indicator biological spores is attached to the inner bottom of the plastic pipe. An openable container containing a liquid culture medium is arranged in the plastic pipe cavity; the outer side of the inner pipe cap is sleeved with an outer pipe cap detachably connected with the outer wall of the plastic pipe, and the outer pipe cap is provided with a flow blocking structure used for adjusting the speed of the sterilizing agent entering the area of the inner pipe cap; the indicator biological spores are pretreated by a stable protective agent containing one or more of polyethylene glycol, trehalose, sorbitol, polyvinylpyrrolidone and glyceryl stearate. The speed of a sterilizing agent entering the device can be limited, the spores are dry in a suspension added with a stable protective agent, the capability of resisting general environmental changes is very good, and the performance of the device can be maintained for a long time.

The invention belongs to the technical field of veterinary drug preparations, and particularly relates to a compound external ointment for treating parasites of dogs and cats and skin tinea and a preparation method, the compound external ointment comprises the following components by mass percent: 2%-12% of selamectin, 3%-20% of imidacloprid, 0.5%-2% of terbinafine hydrochloride, 2%-12% of dipropylene glycol monomethyl ether, 10%-50% of isopropanol, 9%-45% of polyethylene glycol 400 and the balance of water. The adhesive is prepared from, by weight, 9%-45% of polyethylene glycol 3350, 5%-15% of caprylic / capric polyethylene glycol glyceride, 1%-8% of oleyl alcohol, 0.5%-5% of dimeticone, 0.01%-0.1% of butylated hydroxytoluene and 1%-5% of cassava starch polymethylsesquioxane. The preparation method comprises the following steps: uniformly stirring the selamectin, the imidacloprid, the terbinafine hydrochloride and the mixed solvent, then mixing with the matrix (the polyethylene glycol 400 and the polyethylene glycol 3350 are heated and uniformly mixed in advance), the emulsifier and other components, and homogenizing. The compound selamectin ointment prepared by the invention can realize accurate administration at the edge of the auricle of an animal, and not only can ensure that the medicine is fully absorbed, but also can improve the compliance of animal administration; the composition not only can expel parasites in a broad spectrum, but also has broad-spectrum antifungal activity, and can prevent and treat a plurality of skin diseases of pets.

The invention relates to the field of inorganic material preparation, and particularly discloses pseudo-boehmite and a preparation method thereof. A preparation method of pseudo-boehmite comprises the following steps: (1) mixing an aluminum salt solution and an aluminate solution, adding a crystal form regulating agent, and stirring for reaction to obtain a sol system; the crystal form regulating agent is ZnS quantum dots modified by thiohydracrylic acid; (2) adding a pore diameter guiding agent into the sol system, and aging for 6-8 hours; the pore diameter guiding agent is a compound of a polyethylene glycol-polypropylene glycol-polyethylene glycol triblock copolymer and sodium citrate; and (3) carrying out solid-liquid separation on the aged sol system, and washing and drying the obtained solid to obtain the pseudo-boehmite. The proportion of 5-10nm pores of the pseudo-boehmite prepared by the preparation method disclosed by the invention reaches 90% or above, so that the pore distribution requirement of a fine catalytic reaction on the pseudo-boehmite can be met, and the efficient catalytic reaction is favorably realized.

The invention relates to a doxepin hydrochloride tablet. The doxepin hydrochloride tablet is prepared from doxepin hydrochloride, polyethylene glycol 6000, a filling agent, a disintegrating agent, a flow aid and a lubricating agent. The preparation method comprises the following steps: heating and melting polyethylene glycol 6000, adding a doxepin hydrochloride raw material according to a prescription proportion, and uniformly stirring and mixing; and after complete melting, rapidly cooling and solidifying to form a solid dispersion. And after curing, drying in a drying oven, crushing and sieving. And uniformly mixing the crushed particles with the filler and the lubricant, and directly tabletting. The doxepin hydrochloride has high hygroscopicity, is unstable to damp and heat and easily generates a large amount of impurities under strong oxidation conditions, the doxepin hydrochloride is firstly prepared into a solid dispersion and then is directly compressed, so that the medicine is highly dispersed in a carrier material in the states of molecules, colloids, amorphous forms, microcrystals and the like, and the effect of wrapping the medicine is achieved by controlling the ratio of the medicine to the carrier. Direct contact between the medicine and air is avoided, so that the problems of hygroscopicity and instability of the medicine are solved, and the product stability is improved.

The invention relates to a degradable high-strength medical adhesive and a preparation method and application thereof.The medical adhesive is prepared from raw materials through reaction, the raw materials comprise a component A, a component B and a component C. The component A is trihydric alcohol and derivatives thereof and / or trihydric alcohol modified by polyethylene glycol carboxylic acid derivatives and derivatives thereof, and the component C is trihydric alcohol modified by polyethylene glycol carboxylic acid derivatives and derivatives thereof. The component B is isocyanate, amino acid or an amino acid derivative, and the component C is N-methyldiethanolamine and / or bis (2-ethoxyl)-N-methyl-N-trifluoromethyl ammonium iodide and a derivative of the bis (2-ethoxyl)-N-methyl-N-trifluoromethyl ammonium iodide; the molar ratio of-NCO groups in the component B to total-OH groups in the component A and the component C is 2: 1, and the molar ratio of the component A to the component C is (1-9): 2. The component A and the component C are mixed, heated and dissolved, then a catalyst and the component B are added, and a mixed reaction system is obtained; and cooling after the reaction is completed, adding a rheology modifier, a foaming catalyst and a stabilizer, and uniformly mixing to obtain the degradable high-strength medical adhesive which can be applied to a functional composite material.

The invention discloses a bone cement composition and application thereof, and relates to the technical field of bone cement. The bone cement composition comprises a solid phase component and a liquid phase component, wherein the solid phase component comprises 60-75 parts of composite calcium phosphate, 10-20 parts of strontium glass powder, 8-12 parts of a reinforcing agent and 3-7 parts of a solidification reaction regulator; the liquid phase component comprises 20-30 parts of a phosphate buffer solution, 3-8 parts of a sodium citrate solution, 5-15 parts of an anti-inflammatory agent and 1-5 parts of a hyaluronic acid solution. The preparation method comprises the following steps: reacting 1, 10-phenanthrene-2, 9-dicarboxylic acid with 2-aminomethyl furan to obtain an intermediate 1, and reacting the intermediate 1 with poly (ethylene glycol) maleimide to prepare the reinforcing agent. The prepared bone cement composition has good mechanical properties, self-repairing performance and anti-inflammatory performance, and has a good application prospect in the field of bone repairing.

The invention discloses bioactive gel for accelerating wound healing. The gel is prepared from the following raw materials in percentage by weight: 0.8%-1% of bomer 980, 5%-5.5% of glycerol, 15%-20% of white vaseline, 51.7%-55% of phosphate buffer, 1.8%-2% of nano royal jelly acid, 2%-3% of recombinant III type human collagen, 0.4%-0.5% of sodium hyaluronate, 1%-3% of sodium alginate, 20%-25% of polyethylene glycol-400, 1.5%-3% of dopamine-methacrylamide copolymer, 0.5%-0.8% of nano silver and 0.3%-0.5% of phenoxyethanol. The nano royal jelly acid and the nano silver have a synergistic antibacterial effect, so that the inhibition effect on drug-resistant bacteria such as MRSA and pseudomonas aeruginosa is remarkably improved, and meanwhile, the wound epithelization can be accelerated and scar formation can be reduced through the dual effects of the recombinant III type collagen and the acetylated sodium hyaluronate. The defects that a traditional dressing is narrow in antibacterial spectrum, single in repairing effect, poor in environmental adaptability and the like are overcome, and the dressing is particularly suitable for complicated wounds such as diabetic foot ulcer and second-degree burn.

The present invention provides an enzyme preparation for laundry detergent that can effectively improve the washing effect. The enzyme preparation for laundry detergent includes a protease component, a lipase component, and polyethylene glycol. The protease component includes a protease and a protease carrier for immobilizing the protease. The protease carrier includes a porous nanomaterial and polydopamine formed on the surface of the porous nanomaterial. The lipase component includes a lipase and sodium polyoxyalkylene sulfosuccinate. In the enzyme preparation for laundry detergent provided in this solution, the protease and the lipase can maintain good activity for a long time. Therefore, when the enzyme preparation for laundry detergent provided in this solution is applied to the preparation of laundry detergent, the washing effect of the laundry detergent can be effectively improved.

The invention discloses a hydrogel-based helicobacter pylori killing medicine and a preparation method thereof in the technical field of biomedical materials, and the hydrogel medicine adopts a shell-core layered structure and comprises an outer layer and an inner layer; the outer layer is a high-density cross-linked polyethylene glycol diacrylate network, and cellulose nanocrystals modified by silane are dispersed in the polyethylene glycol diacrylate network; pH-sensitive Schiff base bonds and / or boric acid ester bonds are embedded in the inner layer, and an antibacterial agent is loaded on the inner layer. Structural expansion and breaking of the hydrogel are controlled through a multi-layer structure, multiple loaded antibacterial agents are released according to pH response, the influence of drug resistance is avoided through sterilization of multiple mechanisms, the preparation process and device of the hydrogel drug are integrated, the production cost is reduced, and the clinical conversion efficiency is guaranteed.

This invention belongs to the field of natural product extraction technology, specifically relating to a method for extracting total polyphenolic active substances from Gastrodia elata in food and cosmetics. The method uses a eutectic solvent as the extraction solvent, combined with ultrasonic extraction. The hydrogen bond acceptors of the eutectic solvent include polyethylene glycol-200, polyethylene glycol-400, and Tween 80, while the hydrogen bond donors include ethylene glycol, 1,2-propanediol, glucose, glycerol, and xylitol. This invention, using a eutectic solvent combined with ultrasonic extraction, achieves high extraction efficiency of total polyphenolic substances from Gastrodia elata, reaching a maximum of 33.2 mg / g. The extraction method of this invention is simple, has a short extraction time, and is practical, showing great development potential in the fields of medicine, food, and cosmetics.

The present invention relates to a lipid nanoparticle composition comprising sodium DNA, and more particularly, to a lipid nanoparticle composition comprising: sodium DNA as an active ingredient; the sodium bis (lauramide glutamine) lysine is used as an amphiphilic surfactant; the distearoyl phosphatidylcholine is used as an auxiliary surfactant; cholesterol as a stabilizer; the auxiliary stabilizer is selected from the group consisting of PEG-120 stearate, polyglycerol-4 decanoate, a poly (ethylene glycol)-poly (epsilon-caprolactone) copolymer (PEG-PCL copolymer) and a mixture of the PEG-120 stearate, the polyglycerol-4 decanoate and the poly (ethylene glycol)-poly (epsilon-caprolactone) copolymer; and a solvent.

The invention provides a high-barrier nanocellulose-based liquid mulching film and a preparation method thereof. The high-barrier nanocellulose-based liquid mulching film comprises a carboxylated nanocellulose solution, hydrophobic modified starch, a compound emulsifier, glycerol, xanthan gum and potassium humate, the carboxylated nano-cellulose solution is obtained by carboxylating and modifying a nano-cellulose solution through succinic anhydride; the compound emulsifier comprises rosin glyceride, polyethylene glycol 400 and nano silicon dioxide; the hydrophobic modified starch is obtained by sequentially carrying out hydrophobic modification on starch through dodecyl glycidyl ether and crosslinking with glycerol triglycidyl ether. The liquid mulching film provided by the invention has excellent barrier property, mechanical strength and environmental adaptability, the effective covering time in a field is remarkably prolonged, and the repeated application requirement caused by rapid damage of a film layer is reduced.

The invention relates to methoxy polyethylene glycol epoxidation modified silk fibroin and a preparation method thereof, and belongs to the technical field of biological extraction. The method comprises the following steps: adding a low-concentration hydrogen bond inhibitor and a pH regulator into a regenerated silk fibroin solution, mixing, adding trypsin, incubating, inactivating, carrying out solid-liquid separation, and taking a solid phase to obtain a silk fibroin solid; then mixing and activating with an inorganic salt solution, performing epoxy co-incubation with methoxy polyethylene glycol after activation, and performing purification treatment to obtain a chemically grafted silk fibroin solution. The invention provides a low-concentration hydrogen bond inhibition-pH regulation combined enzymolysis technology, a dissolution modification technology of a precipitation layer after enzymolysis and a technical scheme of inorganic salt solution activation / methoxy polyethylene glycol epoxy synergistic chemical modification for the first time, so that the problems that the proteolysis effect is low and the enzymatic activity cannot be maintained for a long time are solved; and the precipitation layer is successfully prepared into a stable solution, so that the success rate of chemical modification of the silk fibroin is greatly improved, and subsequent further development and use are facilitated.

The invention relates to a dexmedetomidine hydrochloride microneedle which is prepared from a drug-loading needle body layer and a substrate layer, the volume ratio of the drug-loading needle body layer to the substrate layer is 1: 100-200, the drug-loading needle body layer is prepared from polyvinylpyrrolidone and dexmedetomidine hydrochloride according to the mass ratio of 1-15: 1, and the substrate layer is prepared from polyethylene glycol diacrylate through photo-crosslinking. The dexmedetomidine hydrochloride microneedle disclosed by the invention has the advantages that the dexmedetomidine hydrochloride microneedle takes effect quickly, is long in drug effect maintenance time, is non-irritant to skin, avoids infection risk, realizes percutaneous precise administration of dexmedetomidine hydrochloride, and remarkably improves bioavailability and medication safety and effectiveness of dexmedetomidine hydrochloride.

The invention discloses a dual stimuli-responsive polymer micelle as well as a preparation method and application thereof. The micelle is jointly formed by a phenylboronic acid modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer and a catechol modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer, wherein the phenylboronic acid modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer is used for modifying the phenylboronic acid; when the micelle is formed, pH and ROS can be formed in a hydrophobic core to stimulate corresponding boric acid ester bonds; the micelle is used for loading hydrophobic antitumor drugs. The polymer micelle prepared by the invention can be stable in an in-vivo circulating physiological environment, and makes stimulation response to a tumor microenvironment to cause structure loosening or dissociation, so that effective delivery of hydrophobic antitumor drugs is realized, the problems of instability of the micelle in vivo and drug pre-leakage are effectively solved, and the drug delivery efficiency is improved. Theoretical and practical basis is provided for promoting cancer treatment of a polymer micelle drug delivery system.