Biodegradable fluorourcacil polyester medicine-carried nanospheres and its preparation method

A fluorouracil and drug-loaded nanotechnology, which is applied in the field of biodegradable polyester-coated fluorouracil drug-loaded nanospheres and its preparation, can solve the problems of high preparation conditions and low drug loading of microspheres, and achieve significant sustained release Effect, uniform diameter distribution, effect of reducing particle size
CN101053553AInactive Publication Date: 2007-10-17JILIN UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JILIN UNIV
Publication Date
2007-10-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to biodegradable fluorouracil(Fu) polyester drug-bearing manoparticles with a coating material of polylactic acid, polylactic acid-glycolic acid, polylactic acid-polyethylene glycol block copolymer or polylactic acid-glycolic acid-polyethylene glycol block copolymer and the producing method including: firstly, fully dissolving the copolymer in the dichloromethane, under the ultrasonic shock, injecting the fluorouracil NaOH solution in the dichloromethane solution, dispersing uniformly, forming W / O primary latex, and beating up the primary latex and injecting into the fluorouracil saturated water solution containing 5 wt% of polyvinylalcohol (PVA), and storing in the refrigeratory after freeze-dry. The drug-bearing manoparticle has a drug content which is 10-25% of the microparticle mass, and has a smooth surface, an even diameter distribution, a remarkable slow release function and not adhesive. The micropartical size is 100-1000nm.
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Description

technical field

[0001] The invention relates to a fluorouracil drug-loaded nanosphere and a preparation method thereof, in particular to a biodegradable polyester-wrapped fluorouracil drug-loaded nanosphere and a preparation method thereof. Background technique

[0002] Fluorouracil is a pyrimidine anti-metabolite, which mainly inhibits the formation of thymine nucleotides and DNA biosynthesis through enzyme competition, thereby inhibiting tumor growth. It has a wide anti-cancer spectrum and is effective against colon cancer, rectal cancer, gastric cancer and breast cancer, and is the drug of choice for the treatment of solid tumors. Although the curative effect of fluorouracil is good, it is also highly toxic, and can cause side effects such as severe gastrointestinal reactions and bone marrow suppression, and it disappears from the plasma soon after intravenous injection. 1 / 2 About 10 to 20 minutes. In order to reduce the toxic and side effects of fluorouracil and improv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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