620 results about "Glycolic acid" patented technology

The invention belongs to the technical field of hair care products, and particularly relates to composite acid gel for scalp care and a preparation method thereof. Salicylic acid, glycolic acid, piroctone azelate olamine salt, echinacea purpurea-lactic acid bacteria yeast, an emulsifier and water are combined, wherein the echinacea purpurea-lactic acid bacteria yeast is prepared by performing enzymolysis on echinacea purpurea through bacillus subtilis protease and then performing aerobic fermentation with lactic acid bacteria. Salicylic acid, glycolic acid and azelaic acid in the composite acid gel are compounded, so that stimulation of salicylic acid is weakened, and the effect of dissolving hair follicle grease is reserved; glycolic acid and azelaic acid are added to accelerate keratin metabolism, regulate sebum secretion and create safe and healthy shielding for the scalp environment, and polysaccharide and flavonoid compounds in the echinacea purpurea-lactic acid bacteria leavening are beneficial to exerting the anti-oxidation and immune regulation effects of the echinacea purpurea-lactic acid bacteria leavening. Therefore, the composite acid gel provided by the invention is green, safe and non-irritant, the preparation method is simple and convenient, and the composite acid gel can be used for inhibiting bacteria and reducing scalp inflammation.

The invention discloses bioactive macroporous hydrogel as well as a preparation method and application thereof. The bioactive macroporous hydrogel comprises hydrogel particles and a bioactive load loaded on the hydrogel particles, the hydrogel particles are obtained by mechanically extruding a hydrogel matrix, and the hydrogel matrix is formed by compounding sodium alginate, agarose and methacrylated hyaluronic acid through hydrogen bond crosslinking and photo-crosslinking; the bioactive load comprises: a) small extracellular vesicles of which the surfaces are modified with macrophage targeted CRV peptides; and b) a PLGA (poly (lactic-co-glycolic acid)) microsphere loaded with a cartilage inducer Kartogenin. The bioactive macroporous hydrogel disclosed by the invention has an internally communicated macroporous network, is beneficial to cell infiltration, blood vessel ingrowth and nutrient substance diffusion, and overcomes the defects that the traditional hydrogel is small in pore size and limits cell behaviors. According to the bioactive macroporous hydrogel disclosed by the invention, dual bioactive loads are adopted to synergistically promote tendon-bone healing, so that the treatment effect is better.

The invention relates to the field of skincare products, and particularly discloses skincare gel loaded with ganoderma lucidum exosome and a preparation method of the skincare gel. The skin care gel loaded with the lucid ganoderma exosome is prepared from the following raw materials in parts by weight: 20 to 40 parts of hydrogel matrix, 2 to 4 parts of lucid ganoderma exosome nanoparticles, 2 to 6 parts of niobium carbide nanosheets, 1 to 3 parts of nicotinamide, 0.1 to 2 parts of phenethyl resorcinol and 0.1 to 3 parts of green tea extract, the Mailing exosome nanoparticles are of a core-shell structure, a core layer comprises Mailing exosome and papain in a mass ratio of 1: (0.1-0.2), and a shell layer comprises a polylactic acid-glycolic acid copolymer and a penetration enhancer in a mass ratio of 1: (0.1-0.3). The skin-care gel provided by the invention has remarkable whitening, moisturizing and skin brightening effects.

The invention belongs to the technical field of drug delivery, and particularly relates to an M-coated PLGA-10BX compound as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing 10B-enriched boron nitride (h-10BN); extracting a cell membrane of the macrophage RAW264.7; polylactic acid-glycolic acid copolymer (PLGA) nano particles loaded with h-10BN are prepared; and finally, the bionic nano platform M (at) PLGA-10BN based on the macrophage membrane is prepared. The bionic nano-platform prepared by the invention is uniform in particle size and morphology, has relatively high biological safety, and has no obvious damage to various tissues and visceral organs. The compound can be used as a general platform for boron compound delivery, can also be used as an immune activator, is suitable for intravenous injection administration, and expands the application of boron neutron capture therapy (BNCT) in treatment of glioblastoma (GBM).

The invention discloses a neutral organic chelating cleaning agent for a boiler, and belongs to the field of chemical cleaning of boiler superheaters of thermal power plants. The cleaning agent is prepared from the following components in percentage by weight: 0.5%-5% of ethylenediamine tetraacetic acid ammonium, 0.1%-4% of acetic acid or ammonium acetate, 0.1%-3% of glycollic acid ammonium or glycollic acid, 0.1%-5% of a pH regulator, 0.1%-1% of a cosolvent, 0.2%-0.8% of a corrosion inhibitor SH369, 0.1%-0.6% of a reducing agent, 0.0%-0.3% of a defoaming agent, 0.0%-0.2% of a surfactant and 84%-93% of water, wherein the pH value of the cleaning agent is 6-8; the cosolvent is tartaric acid and / or hydroxybutyl diacid, the surfactant is nonylphenol polyoxyethylene ether, and the reducing agent is hydrazine. The cleaning agent disclosed by the invention has good dissolving capacity on oxide skin, does not generate precipitates to cause pipe blockage, is a neutral solution, is very small in corrosivity, does not generate intergranular corrosion, is beneficial to protecting various pipes of superheaters and reheaters, and is a safe and efficient superheater cleaning agent.

The invention discloses a degradable nanocellulose sustained-release drug-loaded film and a preparation method thereof, and belongs to the technical field of drug functional materials. The preparation method comprises the following steps: mixing and stirring microcrystalline cellulose and 64wt% sulfuric acid solution, centrifuging, dialyzing to be neutral, and freeze-drying to obtain CNCs; cNCs, NaIO4 and water are mixed and then subjected to a light-shielding reaction, ethanol precipitation is added, dialysis purification is conducted, freeze drying is conducted, and formylation modified CNCs are obtained; mixing and stirring the aldehyde modified CNCs, sericin, polyvinyl alcohol, water and a target drug to obtain a core layer solution; dissolving a polylactic acid-glycolic acid copolymer into a mixed solution of chloroform and DMF (Dimethyl Formamide) to obtain a shell solution; the core layer solution and the shell layer solution are subjected to coaxial electrostatic spinning forming to obtain the drug-loaded fiber, then the drug-loaded fiber is subjected to biomimetic mineralization surface modification to obtain the degradable nanocellulose sustained-release drug-loaded film, the drug loading rate is increased, the mechanical property of the drug-loaded film is improved, and the sustained-release and release-controllable effects are achieved.

The present invention relates to an advanced dressing characterized by a powder of polymeric material based on poly(lactic-co-glycolic) acid, functionalized with dextran, maltodextrin, collagen, citric acid, chitosan, polyphenols, colloidal silver, hyaluronic acid and / or salts thereof, polyethylene glycol and alginate. The present invention further relates to a process for producing the powder and the use of the powder in treating non-necrotic skin wounds.

The invention belongs to the field of medicine, and discloses application of POCM-NP-coated A939572 in preparation of a medicine for treating osteoporosis, the POCM-NP-coated A939572 comprises osteoclast precursor cell membrane vesicles and NP-coated A939572 loaded on the osteoclast precursor cell membrane vesicles, and the NP-coated A939572 is PLGA (poly (lactic-co-glycolic acid)) nanoparticles entrapped with the NP-coated A939572. The POCM-NP-coated A939572 obtained by loading the nanoparticles loaded with the A939572 small molecule medicine into the osteoclast precursor cell membrane vesicles has the effect of relieving the osteoporosis, can inhibit osteoclast differentiation and can be used for preventing, treating and relieving the osteoporosis.

The invention provides vitamin B12 modified microspheres capable of efficiently loading His tag recombinant protein as well as a preparation method and application of the vitamin B12 modified microspheres, and belongs to the technical field of biological medicines. The preparation method of the vitamin B12 modified microsphere for efficiently loading the His tag recombinant protein comprises the following steps: (1) carrying out esterification reaction on unsaturated fatty acid containing sulfydryl, disulfide bond or olefinic bond, saturated fatty acid and vitamin B12 to prepare an amphiphilic vitamin B12-lipid conjugate; and (2) taking the amphiphilic vitamin B12-lipid conjugate, PLGA (poly (lactic-co-glycolic acid)), a multi-sulfydryl cross-linking agent and a photoinitiator as raw materials, and preparing the raw materials into microspheres by adopting a microfluidic method, so as to obtain the vitamin B12 modified microspheres capable of efficiently loading various His tag recombinant proteins. The microsphere provided by the invention overcomes the problems of protein load stability and burst release of traditional microspheres, and various different His tag recombinant growth factors can be flexibly selected according to the requirements on different growth factors in treatment of complex bone defects caused by different pathogenesis.

The invention provides an apigenin nanoparticle preparation as well as a preparation method and application thereof. The preparation method comprises the following steps: weighing apigenin, dissolving the apigenin in an acetone solution containing a polylactic acid-glycolic acid copolymer, or dissolving the apigenin in an acetone solution containing the polylactic acid-glycolic acid copolymer and Eudragit S100, and uniformly stirring and mixing at room temperature to obtain a mixed solution; dropwise adding the mixed solution into a polyvinyl alcohol solution, carrying out ultrasonic treatment, and removing the solvent to prepare PANPs or PEANPs. The preparation method is simple, and the prepared PANPs and PEANPs are small in particle size and high in encapsulation efficiency, can effectively penetrate through intestinal epithelial barriers and promote internalization of apigenin into cells, have a good slow release characteristic, can remarkably improve the bioavailability of apigenin, and have a good treatment effect on inflammatory bowel diseases. PANPs has a better treatment effect on ulcerative colitis, and PEANPs has a better treatment effect on diffuse colitis.

The invention relates to an absorbable bone hemostasis and repair stent. The absorbable bone hemostasis and repair stent comprises the following raw materials in parts by weight: 15-60 parts of an excipient, 15-60 parts of a softening agent and 5-70 parts of a bone repair promoting component, the excipient is prepared from a polyoxyethylene-polyoxypropylene copolymer; the softening agent comprises a semi-solid mobile phase polymer; the bone repair promoting component comprises a coating and a core, the coating comprises a polylactic acid-glycolic acid copolymer, zinc stearate and potassium bromide, the core comprises calcium phosphate particles, and the coating wraps the surface of the core. The preparation method comprises the following steps: preparing the bone repair promoting component; and preparing the absorbable bone hemostasis repair stent. The absorbable bone hemostasis and repair stent is high in hemostasis and collapse resistance and has good inflammation regulation and bone repair promoting effects. The absorbable bone hemostasis and repair stent can be used for bone hemostasis and bone repair promotion of any bone injury wound.

The present disclosure provides a hydrogel composition for tissue engineering and regenerative medicine, including naturally derived polymers functionalized with furan groups and nanoparticles of poly(lactic-co-glycolic acid)-poly(ethylene glycol) copolymer functionalized with maleimide groups. Covalent crosslinking via a bioorthogonal Diels-Alder click reaction forms a tunable, biocompatible, and biodegradable three-dimensional network. The hydrogel composition mimics the extracellular matrix and offers adjustable mechanical properties, controlled biodegradation, and therapeutic agent delivery for applications such as cartilage regeneration and drug delivery.

The invention relates to the technical field of drug delivery, and discloses a multilayer drug-loaded microsphere for intraocular sustained-release therapy and a preparation process thereof.The multilayer drug-loaded microsphere comprises a core layer, a middle layer and a shell layer, the core layer is composed of a polylactic acid-glycolic acid copolymer (PLGA) and a first hydrophobic drug, the middle layer is formed by wrapping the core layer with carboxymethyl chitosan, and the shell layer is composed of a first hydrophobic drug and a second hydrophobic drug. The first hydrophobic drug comprises a first therapeutic drug, the middle layer comprises a second therapeutic drug, the shell layer is composed of a polylactic acid-caprolactone copolymer PLCL and a third hydrophilic drug, and the first hydrophobic drug, the second therapeutic drug and the third hydrophilic drug are different from one another. Through the layered design of the core layer, the middle layer and the shell layer and in combination with differential degradation rates of PLGA, carboxymethyl chitosan and PLCL materials, gradient release of hydrophobic and hydrophilic drugs is achieved, a drug release curve is matched with the pathological stage of intraocular diseases, macular degeneration rapidly inhibits vascular leakage in the early stage and continuously resists inflammation in the later stage, and the effect of treating macular degeneration is achieved. And the layered slow-release synergistic treatment effect is verified.

The invention provides a POCD treatment medicine composition with dendrobine delivered by a nano-carrier and application, and belongs to the technical field of medicine. The composition consists of dendrobine, a nano-carrier material and a stabilizer, wherein a nano-carrier is PLGA (poly (lactic-co-glycolic acid)) nanoparticles or lipidosome. The particle size of the composition is 50-150nm, the polydispersity index is less than 0.3, and the loading capacity of dendrobine is 5-15%. The invention also provides two preparation methods of the composition. The PLGA nanoparticles are prepared by adopting an emulsification-solvent evaporation method; the liposome is prepared by adopting a film hydration-ultrasonic extrusion method, and each process parameter is specifically limited. The pharmaceutical composition can significantly improve the brain targeting and bioavailability of dendrobine, and can be used for preparing drugs for preventing or treating postoperative cognitive impairment (POCD), and the administration route can be intravenous injection or nasal administration.

The invention discloses a full-biodegradable bamboo fiber film material and a preparation method thereof. The full-biodegradable bamboo fiber film material is composed of a bamboo fiber composite matrix, a biodegradable reinforcing system and a multifunctional cross-linking agent. The bamboo fiber composite matrix is a mixture of bamboo pulp fiber pretreated by supercritical CO2 and microcrystalline cellulose; the biodegradation enhancing system is composed of nano calcium carbonate-montmorillonite composite particles and a polylactic acid-glycolic acid copolymer, and the composite particles are modified by a silane coupling agent; the multifunctional cross-linking agent is an esterification product of citric acid and glycerol. The preparation method comprises the steps of bamboo fiber supercritical pretreatment, composite reinforced particle preparation, melt extrusion, two-way stretching, gradient heat setting and the like, and finally the antibacterial surface layer is formed through chitosan surface treatment. The material realizes the balance of biodegradability and mechanical properties through raw material synergy and process optimization, and is suitable for the fields of packaging, agricultural coverage and the like.

The present application relates to the technical field of degradable packaging. Particularly disclosed are a degradable food container and a preparation method therefor. The degradable food container comprises a paper food container base body and a degradable coating applied on the paper food container base body, wherein the degradable coating is prepared from the following raw materials in parts by weight: 40-50 parts of polylactic acid; 10-15 parts of polybutylene succinate; 15-20 parts of polyglycolic acid; 10-20 parts of cassava starch; 5-8 parts of an external additive; 1.2-1.8 parts of montmorillonite; 0.2-0.8 parts of boron nitride nanotubes; and 1.5-2.5 parts of modified hemp fibers. The preparation method therefor comprises: heating polylactic acid, polybutylene succinate and polyglycolic acid to a molten state, then adding cassava starch and an external additive thereto, finally adding montmorillonite, boron nitride nanotubes and modified hemp fibers thereto, performing extrusion granulation, melting and then coating same on the surface of the paper food container base body, cooling same, and then cutting and forming same into a container to obtain the degradable food container. The degradable food container of the present application can exhibit excellent temperature change resistance when being subjected to temperature change caused by an external environment.

The invention discloses a functional osteochondral repair material which comprises a cartilage layer, a transition layer and a bone layer which are sequentially connected, the cartilage layer takes hyaluronic acid, I-type collagen and chitosan as base materials, the transition layer takes hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, and the bone layer takes hyaluronic acid, I-type collagen and chitosan as base materials. The bone layer takes beta-tricalcium phosphate, hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, the invention relates to the technical field of medical biological materials, by designing the organic-inorganic composite transition layer, the gradient connection cartilage layer and the bone layer, and the interfacial shear strength is greater than or equal to 0.5 MPa, the problem of interlayer stripping of a traditional layered material is effectively solved, and the medical material has the advantages of high mechanical strength, high mechanical strength and high mechanical strength. According to the selective laser sintering 3D printing material, the shearing stress and the compression stress during joint movement can be borne, mature medical material production equipment such as freeze drying, compression molding and sintering is adopted in the preparation process, large-scale batch production can be achieved, meanwhile, personalized preparation of selective laser sintering 3D printing is supported, and the requirements of different clinical scenes are met.

The invention belongs to the field of skin care and skin disease treatment, and provides a skin care composition and application thereof, and the skin care composition is in a liquid form and comprises recombinant collagen and glycolic acid. The specific low-concentration glycolic acid in the skin care composition disclosed by the invention ensures the mild keratin metabolism capability; the recombinant collagen with high transdermal property can quickly permeate into the deep layer of the skin, and can immediately provide a repairing raw material for the skin while the glycolic acid acts, so that discomforts such as redness and stabbing pain are remarkably relieved, and synchronous skin care and repairing is realized.

The invention discloses a preparation method of an amorphous-nanocrystalline biphase PdCuFe catalyst and application of the amorphous-nanocrystalline biphase PdCuFe catalyst in ethylene glycol electrocatalytic oxidation reaction, and belongs to the field of electrocatalytic materials. According to the method, an amorphous-nanocrystalline coexisting structure of the Pd, Cu and Fe ternary alloy is constructed through pulse electrodeposition, an amorphous phase provides intermediate stable sites with rich defects, a nanocrystalline phase enhances substrate adsorption and reaction activation, and the amorphous phase and the nanocrystalline phase cooperate to achieve efficient oxidation of ethylene glycol to prepare glycollic acid. The glycollic acid Faraday efficiency of the catalyst in a wide potential range (0.5-1.6 V vs.RHE) exceeds 90%, the yield of the catalyst in 1.6 V vs.RHE reaches up to 8.736 mmol.h <-1 >. Cm <-2 >, and the catalyst has excellent anti-poisoning ability and long-term operation stability. The catalyst is simple in preparation method, unique in structure, excellent in performance and suitable for efficient electrocatalytic oxidation of ethylene glycol and other hydroxyl micromolecules (such as glycerol, methanol and ethanol).

The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.

The invention relates to the technical field of waste plastic resource utilization, and particularly provides a method for preparing glycollic acid through high-selectivity photoelectrocatalytic oxidation of polyethylene glycol terephthalate (PET) plastic. The core of the method is that a carbon nitride film loaded and modified by heteroatom doping (sulfur / phosphorus and the like) and an oxidation co-catalyst (Ni (OH) 2, NiFeOOH and the like) is used as a photo-anode, and under the conditions of certain bias voltage, electrolyte pH and composition and light source wavelength, PET oxidation is guided to generate glycolic acid with high selectivity. According to the method, efficient conversion from the PET waste plastics to high-value chemicals is achieved, the Faraday efficiency of glycollic acid in the product can reach 75% or above, and an innovative technical path is provided for plastic pollution abatement and waste turning into wealth.

The invention discloses a compound microorganism freeze-drying protective agent, a preparation method of the compound microorganism freeze-drying protective agent and a use method of the compound microorganism freeze-drying protective agent. Comprising the following raw materials in parts by weight: 0.03 part of disodium ethylene diamine tetraacetate, 5 to 15 parts of trehalose, 2 to 5 parts of sorbitol, 0.5 to 2 parts of ascorbic acid, 0.05 to 0.2 part of N-acetyl-L-cysteine, 0.1 to 0.5 part of polylactic acid-glycolic acid copolymer, 0.01 to 0.05 part of alpha-tocopherol and 1 to 3 parts of bentonite. The PLGA, the alpha-tocopherol and the NAC construct a three-stage synergistic anti-oxidation system from outside to inside: the PLGA is externally blocked, so that rapid consumption of an antioxidant is avoided, and slow release is realized; the alpha-tocopherol realizes oxidative damage repair of cell membranes; nAC maintains the internal reduction environment of cells, reduces oxidative stress and can regenerate alpha-tocopherol at the same time, and reutilization of resources is achieved.

This invention discloses a method for preparing poly(glycolic acid-caprolactone) copolymers, belonging to the field of polymer synthesis technology. The method includes: prepolymerizing ε-caprolactone with a catalyst and initiator at 40–60°C below the melting point of glycolide under an inert atmosphere; adding glycolide and heating to 160–220°C for the main polymerization reaction; after the reaction, dissolving, precipitating, washing, and drying to obtain the poly(glycolic acid-caprolactone) copolymer. This invention utilizes the physical difference in melting points between glycolide and ε-caprolactone, preferentially prepolymerizing ε-caprolactone at a temperature below the melting point of glycolide, resulting in a higher conversion rate of ε-caprolactone than glycolide in the initial stage of the main polymerization, effectively controlling the copolymerization reaction pathway. Using this method, copolymers with a weight-average molecular weight of not less than 100,000 Da and an intrinsic viscosity of 1.8–3.5 dL / g can be obtained within a wide range of glycolide molar content from 15% to 85%, and the degradation behavior is stable and controllable. This method is simple and requires no special equipment or chain extender, making it suitable for the large-scale preparation of medical materials such as absorbable sutures and tissue repair scaffolds.

The invention relates to an allergy-relieving acne-removing composition and a preparation method and application thereof, and the allergy-relieving acne-removing composition comprises the following raw materials in parts by mass: 1-10 parts of VB-IP, 5-20 parts of hydroxyethyl urea, 1-5 parts of coated salicylic acid, 2-10 parts of wild soybean, 1-5 parts of clerodendranthus spicatus, 1-5 parts of rosewood seeds, 1-10 parts of lactobionic acid, 1-10 parts of gluconolactone, 1-10 parts of mandelic acid, 1-10 parts of glycollic acid, 1-5 parts of octyl dodecyl glucoside and 1-5 parts of cetearyl glucoside. 0.5 to 2 parts of phenoxyethanol and 5 to 30 parts of deionized water; the composition comprises the following components: a wild soybean fermentation extract, a clerodendranthus spicatus fermentation extract and a rosewood seed fermentation extract. Compared with the prior art, the formula is stable, penetration can be promoted, cutin renewal can be accelerated, a sebum film can be repaired, sebum can be adjusted, and the acne removing and skin care effects are good.

Provided is a molded product having small anisotropy of strength in a MD direction and a TD direction and a processed article thereof. A molded product (10) includes a glycolic acid polymer and a plurality of fibers (11). The fibers (11) include the fibers oriented in the MD direction and the fibers oriented in a direction along a tangent line to concentric circles in a cross-section orthogonal to the MD direction at a specific ratio.

The present invention relates to a method of adding an isocitrate lyase specific inhibitor to a lactic acid fermentation process to block the production of succinic acid as a byproduct of fermentation. The specific inhibitor includes a combination of one or more of glycolic acid methyl ester, malonic acid dimethyl ester, hydroxymalonic acid diethyl ester, 3-nitropropionic acid ethyl ester, mercuric chloride, or 5,5'-dithiobis(2-nitrobenzoic acid) to effectively reduce the amount of succinic acid in the lactic acid.

The invention discloses a lumepirone long-acting microsphere sustained-release preparation without a release stagnation period in an early stage, which comprises a lumepirone active ingredient and a medicinal polymer auxiliary material in a mass ratio of (1: 4)-(1: 1), the medicinal polymer auxiliary material is at least one of glycolide-lactide copolymers with the weight-average molecular weight of 5000-150000 Da, and the molar ratio of lactic acid units to glycolic acid units of the glycolide-lactide copolymers is (50: 50)-(95: 5). The lumepirone long-acting microsphere sustained-release preparation without a release arrest phase in the early stage is obtained by specially limiting drying conditions in liquid and medicinal polymer auxiliary materials, the release of the lumepirone long-acting microsphere sustained-release preparation can be maintained for 2 weeks to 1 month without oral administration of the long-acting sustained-release microspheres of lumepirone capsules, the safety and effectiveness of the medicine are met, and the sustained-release preparation is suitable for clinical application. Meanwhile, the problems of early-stage long-time stagnant release and early-stage burst release of the long-acting microsphere preparation can be solved, the compliance can be effectively improved, convenience is provided for patients to the maximum extent, and the economic cost is reduced.

The invention discloses a gradient degradation type personalized absorbable sternum fracture fixing plate and a preparation process, and belongs to the technical field of medical implant materials. Comprising an anatomical adaptive plate body and an integrated locking assembly, the plate body is of a partitioned structure of a middle supporting area and an edge buffering area, a gradient pore array penetrating through the thickness direction is formed in the surface of the plate body, and a hydroxyapatite-collagen composite coating is loaded on the inner wall of a pore; the plate body is made of a composite absorbable material through 3D printing forming and hot pressing post-treatment, and the composite absorbable material comprises, by weight, 60%-70% of polylactic acid-glycolic acid copolymer (PLGA, LA / GA = 75 / 25), 15%-20% of silanized magnesium alloy microwires, 5%-10% of hydroxyapatite nano-particles and 5%-10% of polycaprolactone (PCL). Space-time matching of the degradation rate and the bone healing process is achieved through the partition gradient structure, the magnesium alloy microwires enhance the mechanical property and release active ions to promote osteogenesis, and the method has the advantages of personalized adaptation, gradient degradation, bone regeneration promotion and the like.

The application discloses a water-soluble quantum dot nanometer material and a preparation method and application thereof, and the nanometer material comprises quantum dots and carboxyl-terminated poly(lactic-co-glycolic acid) coated on surfaces of the quantum dots. The carboxyl-terminated poly(lactic-co-glycolic acid) is used for encapsulating CsPbBr3 perovskite quantum dots, and a water-soluble perovskite nanocrystal material is prepared, which can retain high quantum yield (PLQY=88%) and water-oxygen resistance (>=30 days) and almost completely retains optical performance of the perovskite quantum dots.

The invention relates to the field of high polymer materials, and provides a high-strength and high-toughness polyglycolic acid grafted copolymer as well as a preparation method and application thereof. The high-strength and high-toughness polyglycolic acid graft copolymer provided by the invention comprises polyglycolic acid and a graft copolymer of a graft comonomer, and a side chain of the graft copolymer contains R3 which is substituted or unsubstituted alkyl or alkoxy or alkenyl or aralkyl or alkaryl. Through a grafting reaction process, the polyglycolic acid resin with synergistically improved mechanical strength and toughness is obtained. The invention provides an effective solution for preparing the intrinsic high-toughness PGA.