337 results about "Glycolic acid" patented technology

The invention belongs to the technical field of hair care products, and particularly relates to composite acid gel for scalp care and a preparation method thereof. Salicylic acid, glycolic acid, piroctone azelate olamine salt, echinacea purpurea-lactic acid bacteria yeast, an emulsifier and water are combined, wherein the echinacea purpurea-lactic acid bacteria yeast is prepared by performing enzymolysis on echinacea purpurea through bacillus subtilis protease and then performing aerobic fermentation with lactic acid bacteria. Salicylic acid, glycolic acid and azelaic acid in the composite acid gel are compounded, so that stimulation of salicylic acid is weakened, and the effect of dissolving hair follicle grease is reserved; glycolic acid and azelaic acid are added to accelerate keratin metabolism, regulate sebum secretion and create safe and healthy shielding for the scalp environment, and polysaccharide and flavonoid compounds in the echinacea purpurea-lactic acid bacteria leavening are beneficial to exerting the anti-oxidation and immune regulation effects of the echinacea purpurea-lactic acid bacteria leavening. Therefore, the composite acid gel provided by the invention is green, safe and non-irritant, the preparation method is simple and convenient, and the composite acid gel can be used for inhibiting bacteria and reducing scalp inflammation.

The invention belongs to the technical field of drug delivery, and particularly relates to an M-coated PLGA-10BX compound as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing 10B-enriched boron nitride (h-10BN); extracting a cell membrane of the macrophage RAW264.7; polylactic acid-glycolic acid copolymer (PLGA) nano particles loaded with h-10BN are prepared; and finally, the bionic nano platform M (at) PLGA-10BN based on the macrophage membrane is prepared. The bionic nano-platform prepared by the invention is uniform in particle size and morphology, has relatively high biological safety, and has no obvious damage to various tissues and visceral organs. The compound can be used as a general platform for boron compound delivery, can also be used as an immune activator, is suitable for intravenous injection administration, and expands the application of boron neutron capture therapy (BNCT) in treatment of glioblastoma (GBM).

The invention provides vitamin B12 modified microspheres capable of efficiently loading His tag recombinant protein as well as a preparation method and application of the vitamin B12 modified microspheres, and belongs to the technical field of biological medicines. The preparation method of the vitamin B12 modified microsphere for efficiently loading the His tag recombinant protein comprises the following steps: (1) carrying out esterification reaction on unsaturated fatty acid containing sulfydryl, disulfide bond or olefinic bond, saturated fatty acid and vitamin B12 to prepare an amphiphilic vitamin B12-lipid conjugate; and (2) taking the amphiphilic vitamin B12-lipid conjugate, PLGA (poly (lactic-co-glycolic acid)), a multi-sulfydryl cross-linking agent and a photoinitiator as raw materials, and preparing the raw materials into microspheres by adopting a microfluidic method, so as to obtain the vitamin B12 modified microspheres capable of efficiently loading various His tag recombinant proteins. The microsphere provided by the invention overcomes the problems of protein load stability and burst release of traditional microspheres, and various different His tag recombinant growth factors can be flexibly selected according to the requirements on different growth factors in treatment of complex bone defects caused by different pathogenesis.

The present disclosure provides a hydrogel composition for tissue engineering and regenerative medicine, including naturally derived polymers functionalized with furan groups and nanoparticles of poly(lactic-co-glycolic acid)-poly(ethylene glycol) copolymer functionalized with maleimide groups. Covalent crosslinking via a bioorthogonal Diels-Alder click reaction forms a tunable, biocompatible, and biodegradable three-dimensional network. The hydrogel composition mimics the extracellular matrix and offers adjustable mechanical properties, controlled biodegradation, and therapeutic agent delivery for applications such as cartilage regeneration and drug delivery.

The present application relates to the technical field of degradable packaging. Particularly disclosed are a degradable food container and a preparation method therefor. The degradable food container comprises a paper food container base body and a degradable coating applied on the paper food container base body, wherein the degradable coating is prepared from the following raw materials in parts by weight: 40-50 parts of polylactic acid; 10-15 parts of polybutylene succinate; 15-20 parts of polyglycolic acid; 10-20 parts of cassava starch; 5-8 parts of an external additive; 1.2-1.8 parts of montmorillonite; 0.2-0.8 parts of boron nitride nanotubes; and 1.5-2.5 parts of modified hemp fibers. The preparation method therefor comprises: heating polylactic acid, polybutylene succinate and polyglycolic acid to a molten state, then adding cassava starch and an external additive thereto, finally adding montmorillonite, boron nitride nanotubes and modified hemp fibers thereto, performing extrusion granulation, melting and then coating same on the surface of the paper food container base body, cooling same, and then cutting and forming same into a container to obtain the degradable food container. The degradable food container of the present application can exhibit excellent temperature change resistance when being subjected to temperature change caused by an external environment.

The invention discloses a functional osteochondral repair material which comprises a cartilage layer, a transition layer and a bone layer which are sequentially connected, the cartilage layer takes hyaluronic acid, I-type collagen and chitosan as base materials, the transition layer takes hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, and the bone layer takes hyaluronic acid, I-type collagen and chitosan as base materials. The bone layer takes beta-tricalcium phosphate, hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, the invention relates to the technical field of medical biological materials, by designing the organic-inorganic composite transition layer, the gradient connection cartilage layer and the bone layer, and the interfacial shear strength is greater than or equal to 0.5 MPa, the problem of interlayer stripping of a traditional layered material is effectively solved, and the medical material has the advantages of high mechanical strength, high mechanical strength and high mechanical strength. According to the selective laser sintering 3D printing material, the shearing stress and the compression stress during joint movement can be borne, mature medical material production equipment such as freeze drying, compression molding and sintering is adopted in the preparation process, large-scale batch production can be achieved, meanwhile, personalized preparation of selective laser sintering 3D printing is supported, and the requirements of different clinical scenes are met.

The invention belongs to the field of skin care and skin disease treatment, and provides a skin care composition and application thereof, and the skin care composition is in a liquid form and comprises recombinant collagen and glycolic acid. The specific low-concentration glycolic acid in the skin care composition disclosed by the invention ensures the mild keratin metabolism capability; the recombinant collagen with high transdermal property can quickly permeate into the deep layer of the skin, and can immediately provide a repairing raw material for the skin while the glycolic acid acts, so that discomforts such as redness and stabbing pain are remarkably relieved, and synchronous skin care and repairing is realized.

The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.

The invention relates to the technical field of waste plastic resource utilization, and particularly provides a method for preparing glycollic acid through high-selectivity photoelectrocatalytic oxidation of polyethylene glycol terephthalate (PET) plastic. The core of the method is that a carbon nitride film loaded and modified by heteroatom doping (sulfur / phosphorus and the like) and an oxidation co-catalyst (Ni (OH) 2, NiFeOOH and the like) is used as a photo-anode, and under the conditions of certain bias voltage, electrolyte pH and composition and light source wavelength, PET oxidation is guided to generate glycolic acid with high selectivity. According to the method, efficient conversion from the PET waste plastics to high-value chemicals is achieved, the Faraday efficiency of glycollic acid in the product can reach 75% or above, and an innovative technical path is provided for plastic pollution abatement and waste turning into wealth.

The invention discloses a compound microorganism freeze-drying protective agent, a preparation method of the compound microorganism freeze-drying protective agent and a use method of the compound microorganism freeze-drying protective agent. Comprising the following raw materials in parts by weight: 0.03 part of disodium ethylene diamine tetraacetate, 5 to 15 parts of trehalose, 2 to 5 parts of sorbitol, 0.5 to 2 parts of ascorbic acid, 0.05 to 0.2 part of N-acetyl-L-cysteine, 0.1 to 0.5 part of polylactic acid-glycolic acid copolymer, 0.01 to 0.05 part of alpha-tocopherol and 1 to 3 parts of bentonite. The PLGA, the alpha-tocopherol and the NAC construct a three-stage synergistic anti-oxidation system from outside to inside: the PLGA is externally blocked, so that rapid consumption of an antioxidant is avoided, and slow release is realized; the alpha-tocopherol realizes oxidative damage repair of cell membranes; nAC maintains the internal reduction environment of cells, reduces oxidative stress and can regenerate alpha-tocopherol at the same time, and reutilization of resources is achieved.

This invention discloses a method for preparing poly(glycolic acid-caprolactone) copolymers, belonging to the field of polymer synthesis technology. The method includes: prepolymerizing ε-caprolactone with a catalyst and initiator at 40–60°C below the melting point of glycolide under an inert atmosphere; adding glycolide and heating to 160–220°C for the main polymerization reaction; after the reaction, dissolving, precipitating, washing, and drying to obtain the poly(glycolic acid-caprolactone) copolymer. This invention utilizes the physical difference in melting points between glycolide and ε-caprolactone, preferentially prepolymerizing ε-caprolactone at a temperature below the melting point of glycolide, resulting in a higher conversion rate of ε-caprolactone than glycolide in the initial stage of the main polymerization, effectively controlling the copolymerization reaction pathway. Using this method, copolymers with a weight-average molecular weight of not less than 100,000 Da and an intrinsic viscosity of 1.8–3.5 dL / g can be obtained within a wide range of glycolide molar content from 15% to 85%, and the degradation behavior is stable and controllable. This method is simple and requires no special equipment or chain extender, making it suitable for the large-scale preparation of medical materials such as absorbable sutures and tissue repair scaffolds.

Provided is a molded product having small anisotropy of strength in a MD direction and a TD direction and a processed article thereof. A molded product (10) includes a glycolic acid polymer and a plurality of fibers (11). The fibers (11) include the fibers oriented in the MD direction and the fibers oriented in a direction along a tangent line to concentric circles in a cross-section orthogonal to the MD direction at a specific ratio.

The invention discloses a lumepirone long-acting microsphere sustained-release preparation without a release stagnation period in an early stage, which comprises a lumepirone active ingredient and a medicinal polymer auxiliary material in a mass ratio of (1: 4)-(1: 1), the medicinal polymer auxiliary material is at least one of glycolide-lactide copolymers with the weight-average molecular weight of 5000-150000 Da, and the molar ratio of lactic acid units to glycolic acid units of the glycolide-lactide copolymers is (50: 50)-(95: 5). The lumepirone long-acting microsphere sustained-release preparation without a release arrest phase in the early stage is obtained by specially limiting drying conditions in liquid and medicinal polymer auxiliary materials, the release of the lumepirone long-acting microsphere sustained-release preparation can be maintained for 2 weeks to 1 month without oral administration of the long-acting sustained-release microspheres of lumepirone capsules, the safety and effectiveness of the medicine are met, and the sustained-release preparation is suitable for clinical application. Meanwhile, the problems of early-stage long-time stagnant release and early-stage burst release of the long-acting microsphere preparation can be solved, the compliance can be effectively improved, convenience is provided for patients to the maximum extent, and the economic cost is reduced.

The invention discloses a gradient degradation type personalized absorbable sternum fracture fixing plate and a preparation process, and belongs to the technical field of medical implant materials. Comprising an anatomical adaptive plate body and an integrated locking assembly, the plate body is of a partitioned structure of a middle supporting area and an edge buffering area, a gradient pore array penetrating through the thickness direction is formed in the surface of the plate body, and a hydroxyapatite-collagen composite coating is loaded on the inner wall of a pore; the plate body is made of a composite absorbable material through 3D printing forming and hot pressing post-treatment, and the composite absorbable material comprises, by weight, 60%-70% of polylactic acid-glycolic acid copolymer (PLGA, LA / GA = 75 / 25), 15%-20% of silanized magnesium alloy microwires, 5%-10% of hydroxyapatite nano-particles and 5%-10% of polycaprolactone (PCL). Space-time matching of the degradation rate and the bone healing process is achieved through the partition gradient structure, the magnesium alloy microwires enhance the mechanical property and release active ions to promote osteogenesis, and the method has the advantages of personalized adaptation, gradient degradation, bone regeneration promotion and the like.

Provided is a plug that can maintain a plugged state for a prescribed period even in a fluid or water having a high temperature and a low salt concentration. A plug (5) for temporarily blocking the flow of a fluid in a well, the plug being provided with a resin molded body formed of a polyglycolic acid resin composition containing polyglycolic acid and a cyclic carbodiimide compound, the concentration of carbodiimide groups being 15 eq / t or more, or the plug being composed of the resin molded body.

The invention provides a cardiac targeting nano drug delivery carrier based on recombinant apolipoprotein, a system, a preparation method and application. The cardiac targeting nano drug delivery carrier comprises a nano carrier core and a functional layer covalently coupled to the surface of the nano carrier core, the nano carrier core comprises an amphiphilic copolymer formed by polylactic acid-glycolic acid and polyethylene glycol; the functional layer comprises recombinant apolipoprotein A-I and heart targeting peptide; the recombinant apolipoprotein A-I contains mutation sites E191A and F225W, and the recombinant apolipoprotein A-I contains mutation sites F225W; the amino acid sequence of the recombinant apolipoprotein A-I is as shown in SEQ ID NO: 1. The cardiac targeting nano drug delivery system based on the recombinant apolipoprotein has the functions of long circulation, cardiac targeting and coordinated regulation and control of metabolism and inflammation, and can be used for precise treatment of chronic heart failure.

A recovery treatment method for ammonia-containing tail gas in the later stage of aromatic nitrile synthesis. The method comprises: introducing the ammonia-containing tail gas sequentially into a first spray absorption tower and a second spray absorption tower; absorbing, in a liquid phase, ammonia from the ammonia-containing tail gas to realize the recovery of ammonia; and directly discharging exhaust gas; an absorbent A in the first spray absorption tower is water; and an absorbent B in the second spray absorption tower comprises glycolic acid, vinylphosphonic acid and aluminum sulfate. In the method, the recovery of ammonia from the ammonia-containing tail gas is increased by means of two-stage spraying, and the ammonia content in the treated tail gas is low and satisfies emission standards.

This invention proposes a method for synthesizing glyoxylic acid from methyl glycolate. Using methyl glycolate and oxygen / water as raw materials, glyoxylic acid is produced in a one-step process. This invention employs a novel catalyst based on ZSM-5 molecular sieve, modified with transition metals and organic bases, and finally extruded into strips. This catalyst can catalyze both oxidation and hydrolysis. This route is characterized by its simplicity, high reactivity, and high catalytic selectivity, making it a green route for glyoxylic acid synthesis.

The invention discloses a hydrogel composition for three-dimensional culture of tumor cells and a preparation method of the hydrogel composition. The hydrogel composition is prepared from poly (lactic acid-glycolic acid) copolymer-polyethylene glycol-poly (lactic acid-glycolic acid) copolymer PLGA-PEG-PLGA and methylacryloyl gelatin GelMA, the mass ratio of the poly (lactic acid-glycolic acid) copolymer-polyethylene glycol-poly (lactic acid-glycolic acid) copolymer PLGA-PEG-PLGA to the methylacryloyl gelatin GelMA is (2-5): 10. According to the hydrogel composition, methacrylated gelatin GelMA is used as a main substrate, so that good biocompatibility and cell adhesion are provided; according to the invention, polylactic acid-glycolic acid copolymer-polyethylene glycol-polylactic acid-glycolic acid copolymer PLGA-PEG-PLGA is used as an auxiliary component, lactic acid is generated through biodegradation of the polylactic acid-glycolic acid copolymer-polyethylene glycol-polylactic acid-glycolic acid copolymer-PEG-PLGA, the pH of a microenvironment is dynamically reduced to 6.5-6.9, tumor acidic conditions are simulated, and pores formed after degradation can provide more growth and invasion spaces for tumor cells.

The invention provides a long-acting microsphere sustained release preparation and a preparation method thereof, and belongs to the technical field of sustained release preparations, the long-acting microsphere sustained release preparation is prepared from the following raw materials of effective components: 9.5 to 10.5 parts of antipsychotic drug, 48 to 50 parts of hydroxypropyl-beta-cyclodextrin, 50 to 52 parts of polylactic acid-glycolic acid copolymer, 1.25 to 1.3 parts of glycerol triacetate and 10 to 11 parts of polyvinyl alcohol. The preparation method comprises the following steps: firstly, the hydroxypropyl-beta-cyclodextrin is used for clathration of the antipsychotic drug, the obtained clathrate compound is further clathrated by the polylactic acid-glycolic acid copolymer, and the long-acting microsphere sustained release preparation is obtained. According to the invention, the double-valve design of beta-CD and PLGA synergistic inclusion is utilized, so that the preparation can realize two-stage release; the macroscopic slow release characteristic of the PLGA is combined with the microcosmic express characteristic of the hydroxypropyl-beta-cyclodextrin, so that the technical limitation of a single carrier is broken through.

The invention discloses a hair-growing liniment and a preparation method thereof, and belongs to the technical field of pharmacy. The liniment comprises the following components in percentage by weight: 1-10% of minoxidil microspheres, 5-20% of a film-forming agent, 0.5-5% of a polypeptide compound, 5-30% of a liquid auxiliary material and the balance of deionized water. Wherein the minoxidil microspheres are of a three-layer structure composed of minoxidil in the inner layer, nano enzyme (cerium dioxide) in the middle layer and lactic acid-glycolic acid ester copolymer or chitosan in the outer layer, and controlled release and targeted delivery are achieved; the polypeptide compound is a compound of oldenlandia diffusa polypeptide and a copper curcumin derivative, and has the effect of synergistically repairing a hair follicle microenvironment. Tests prove that the liniment can remarkably prolong the release time of minoxidil, increase the retention volume of minoxidil in hair follicle parts and reduce absorption of the whole body, shows a hair growth promoting effect superior to that of a traditional preparation and a single-layer microsphere preparation in an animal model, and has good stability and use comfort.

The present application relates to microspheres having a physiologically active substance uniformly dispersed therein and sustained-release preparations containing the same. In the present application, microspheres are provided, which are microspheres having a physiologically active substance uniformly dispersed therein with a lactic acid / glycolic acid copolymer (PLGA) as a main component, characterized in that the average volume-based particle diameter of the microspheres is 1 μm or more and 150 μm or less, and no lump or pore of the physiologically active substance of 1.5 μm or more is present in the microspheres. The microspheres of the present application can appropriately control the initial release amount of the physiologically active substance and the release rate during the period thereafter, and continuously release the physiologically active substance in vivo for a certain period.

This invention discloses an environmentally friendly multifunctional stainless steel cleaning agent and its preparation method, belonging to the technical field of stainless steel surface cleaning materials. The method involves grinding diatomaceous earth into powder, drying it, calcining it, cooling it, and then sieving it to obtain diatomaceous earth powder. The diatomaceous earth powder, a portion of water, polyacrylic acid, polyvinyl alcohol, polydimethylsiloxane, and silica are mixed and then ball-milled to obtain a ball mill slurry. The ball mill slurry, fatty amine polyoxyethylene ether, lauric acid diethanolamide, and glycolic acid are added to a reaction vessel, heated and stirred, and then cooled to obtain mixture A. Carboxymethyl cellulose, sodium tripolyphosphate, calcium lignosulfonate, glycerol phospholipids, and the remaining water are added to mixture A, heated and stirred, and then cooled to obtain the environmentally friendly multifunctional stainless steel cleaning agent. This cleaning agent is water-based and does not contain strong acids, strong alkalis, or other chemicals, avoiding secondary corrosion of stainless steel. The preparation method is simple and suitable for mass production.

This invention discloses a method for preparing self-healing concrete based on microbial gene programming, belonging to the field of building materials technology. The method includes: constructing a recombinant engineered strain incorporating a urease gene cluster and a carbonic anhydrase gene; preparing a spore suspension and protecting it with a three-layer microencapsulation system of sodium alginate / chitosan / gelatin; preparing nutrient-releasing microspheres encapsulating calcium lactate and urea in a polylactic acid-glycolic acid copolymer; and mixing cement, standard sand, water, fly ash, microencapsulated spore particles, nutrient-releasing microspheres, nano-silica, and modified bentonite to prepare self-healing concrete. This invention enhances the urease activity of the strain through genetic engineering, protects the spores using a three-layer microencapsulation technology, and combines a nutrient-releasing system and nano-synergists to achieve efficient self-repair of concrete cracks.

The invention provides a sequential slow-release hydrogen sulfide nerve repair conduit and a preparation method thereof, and belongs to the technical field of biological materials. The sequential slow-release hydrogen sulfide nerve repair conduit comprises degradable temperature-sensitive polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel and a pH response hydrogen sulfide donor, wherein the degradable polymer conduit is filled with the degradable temperature-sensitive polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel, and the pH response hydrogen sulfide donor is loaded on the hydrogel. In the application, the pH response donor can respond to an acidic microenvironment of degradation of polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel, release hydrogen sulfide and relieve the acidic environment generated by degradation of the hydrogel at the same time, and form a dual supply mechanism with cysteine (endogenous hydrogen sulfide precursor) obtained by degradation of the hydrogel; nerve regeneration and angiogenesis are synergistically promoted, and oxidative stress is regulated; and the hydrogel is accelerated to degrade during excessive oxidative stress, so that hydrogen sulfide is released as required, and the core problems of insufficient blood supply, unbalanced acidic microenvironment and slow nerve regeneration are synchronously solved.

The application discloses a kind of sustainable oxygen production sonodynamic therapy nanoparticles, including core-shell structure, the core of core-shell structure is located in shell inside, the core of core-shell structure is manganese oxide nanoparticle, the shell of core-shell structure is the high molecular polymer of carrying sound sensitizer, manganese dioxide nanoparticle is manganese dioxide nanoparticle, sound sensitizer is one of porphyrin and its derivatives, high molecular polymer is polylactic acid glycolic acid copolymer, this kind of sustainable oxygen production sonodynamic therapy nanoparticles by using high molecular polymer simultaneously carrying manganese dioxide nanoparticle and sound sensitizer to enhance SDT effect, high molecular polymer has good biocompatibility and drug controlled release performance, not only can reduce the toxicity of manganese dioxide to normal tissue, can also make it continuously controllable with tumor site excess H2O2 Reaction generates oxygen, reverses tumor hypoxic microenvironment while providing sufficient oxygen for SDT, under the action of ultrasound, generate a large amount of ROS to inhibit tumor.

This invention discloses a penicillin V potassium capsule and its preparation method. The preparation method includes: preparing modified polylactic acid glycolic acid copolymer microspheres; mixing penicillin V potassium micropowder with the modified polylactic acid glycolic acid copolymer microspheres, adding fumed silica and anhydrous calcium hydrogen phosphate for further mixing to obtain a blend; granulating the blend using a dry granulation method; filling the obtained granules into capsules, polishing, and packaging; and modifying the polylactic acid glycolic acid copolymer with povidone and ethyl cellulose to obtain the modified polylactic acid glycolic acid copolymer microspheres. This invention designs polylactic acid glycolic acid copolymer microspheres that are double-modified with povidone and ethyl cellulose, resulting in better drug loading flowability, more stable mixing uniformity, and significantly improved flowability compared to penicillin V potassium powder. The addition of fumed silica and anhydrous calcium phosphate further enhances antistatic properties and reduces the powder return rate.

The present application relates to a kind of cat rhinotracheitis, feline calicivirus disease, cat pancytopenia triple subunit vaccine, preparation method and its application.The present application is expressed antigen protein using CHO cell strain, and synergistic effect is combined molecular adjuvant (IL-2, GM-CSF, CpG) with MF59 nanoemulsion, molecular adjuvant composition is adsorbed on the surface of MF59 nanoemulsion, then embedded in polylactic acid-glycolic acid copolymer microsphere, mixed with triple subunit protein to form vaccine preparation.The vaccine prepared in the present application can stimulate humoral immunity and cellular immunity simultaneously by subcutaneous or intramuscular injection, significantly improve antibody titer and attack protection rate, prolong immune protection period, and reduce injection site adverse reactions.The synergistic effect of protein and molecular adjuvant and MF59 makes the vaccine superior to traditional subunit vaccine in safety, stability and immunological efficacy, and is suitable for high-efficiency prevention of three viral infectious diseases in feline.

The invention discloses a superfine medium-entropy nanoparticle catalyst for electrochemical oxidation of ethylene glycol and other micromolecules as well as a preparation method and application of the superfine medium-entropy nanoparticle catalyst. The catalyst comprises a superfine medium-entropy nano-particle metal material and a conductive substrate material, the superfine medium-entropy nano-particle metal material comprises copper metal and at least two precious metals, and the catalyst has outstanding catalytic ability. The preparation method of the catalyst is simple and convenient, and only the superfine medium-entropy nanoparticle metal material needs to be synthesized through a solvothermal method and is loaded on the conductive substrate material; the temperature of the whole synthesis process is lower than 200 DEG C, so that the problems of high cost, high energy consumption, poor stability, large potential safety hazard and the like in the traditional synthesis method are solved. The superfine medium-entropy nanoparticle catalyst prepared by the invention shows excellent performance in oxidation of micromolecules such as electro-catalysis ethylene glycol and the like. By taking ethylene glycol electrooxidation as an example, the Pb-CuPtPd MEANs-C can efficiently and stably convert ethylene glycol into glycollic acid, the mass activity of the Pb-CuPtPd MEANs-C under 0.9 V vs.RHE reaches up to 14 A mg <-1 > PtPd, and the Faraday efficiency (FEGA) of glycollic acid production is 82.3%.

The present application relates to microspheres in which a physiologically active substance is uniformly dispersed and a sustained release preparation containing the same. In the present application, provided are microspheres having a lactic acid / glycolic acid copolymer (PLGA) as a main component in which a physiologically active substance is uniformly dispersed, the microspheres being characterized in that the average volume-based particle diameter of the microspheres is 1 [mu] m to 150 [mu] m, and blocks or pores of the physiologically active substance are not present in the microspheres in an amount of 1.5 [mu] m or more. The microspheres according to the present invention can appropriately control the initial release amount of a physiologically active substance and the release rate during the subsequent release period, and can continuously release the physiologically active substance in a living body for a certain period of time.