898 results about "Glycolic acid" patented technology

The invention discloses an absorbable suture line for surgical suture and a preparation method thereof, and relates to the technical field of medical materials. The absorbable suture line for surgical suture is prepared from the following raw materials in parts by weight: 50 to 65 parts of polylactic acid, 15 to 20 parts of polyglycolic acid, 3 to 5 parts of sodium carboxymethyl cellulose, 3 to 8 parts of a toughening agent, 3 to 6 parts of an antibacterial agent, 0.3 to 0.8 part of a lubricating agent, 1 to 2 parts of sodium hyaluronate and 5 to 10 parts of polyvinyl alcohol. The toughening agent is obtained by reacting hydroxyethyl acrylate with ethylenediamine to generate a four-arm compound and then reacting with 6-caprolactone and DL-lactide. The absorbable suture line for surgical suture prepared by the invention has excellent tensile property and antibacterial property, and can meet the application requirements of clinical medical treatment.

The invention relates to an oral mucosa repairing medicine and a preparation method thereof, and belongs to the technical field of medicines, the medicine comprises barnacle peptide, salivary lactobacillus, resveratrol, a biphasic adhesion matrix, hydroxyapatite, vitamin B family and other components. The preparation method comprises the following steps: sequentially carrying out enzymolysis on barnacle gooseneck by pepsin and lumbrukinase to obtain barnacle peptide. The double-phase adhesion matrix comprises a water-phase matrix, an oil-phase matrix and lecithin; the water-phase matrix contains a chondroitin sulfate-chitosan quaternary ammonium salt compound, sodium alginate and other components; the oil-phase matrix comprises sesame oil, beeswax, a polylactic acid-glycolic acid copolymer and the like. According to the invention, barnacle peptide and salivary lactobacillus are prepared by adopting a special method and are matched with resveratrol for use, so that multi-target and multi-path promotion of oral mucosa repair can be realized; the chondroitin sulfate-chitosan quaternary ammonium salt compound is prepared through electrostatic and physical embedding, the chondroitin sulfate-chitosan quaternary ammonium salt compound is matched with other components to prepare the biphasic adhesion matrix, the biocompatibility is good, the adhesion is high, and the action time of a sustained-release drug is well prolonged.

The invention relates to the technical field of dental restoration materials, in particular to a bacteriostatic dental restoration composite film and a preparation method thereof. The oral cavity restoration composite film is composed of an upper-layer antibacterial film, a middle-layer polycaprolactone fiber film and a lower-layer bone restoration film. The upper-layer antibacterial film is prepared from the following components in parts by weight: 3 to 4 parts of cinnamon essential oil, 0.5 to 1 part of xanthan gum, 0.5 to 1 part of seed meal protein, 0.1 to 0.15 part of tannic acid, 5 to 7 parts of silk fibroin, 1 to 1.5 parts of polylactic acid, 0.6 to 1 part of chitosan, 1 to 1.5 parts of polyvinyl alcohol and 1.5 to 2.5 parts of glycerol; the lower-layer bone repair membrane is prepared from the following raw materials in parts by weight: 2 to 3 parts of nano-hydroxyapatite, 3 to 5 parts of citric acid, 6 to 9 parts of lactic acid, 3 to 4 parts of tyrosine, 1 to 2 parts of glycollic acid, 2 to 3 parts of casein, 0.2 to 0.3 part of hyperoside and 1 to 2 parts of gelatin.

The invention belongs to the technical field of hair care products, and particularly relates to composite acid gel for scalp care and a preparation method thereof. Salicylic acid, glycolic acid, piroctone azelate olamine salt, echinacea purpurea-lactic acid bacteria yeast, an emulsifier and water are combined, wherein the echinacea purpurea-lactic acid bacteria yeast is prepared by performing enzymolysis on echinacea purpurea through bacillus subtilis protease and then performing aerobic fermentation with lactic acid bacteria. Salicylic acid, glycolic acid and azelaic acid in the composite acid gel are compounded, so that stimulation of salicylic acid is weakened, and the effect of dissolving hair follicle grease is reserved; glycolic acid and azelaic acid are added to accelerate keratin metabolism, regulate sebum secretion and create safe and healthy shielding for the scalp environment, and polysaccharide and flavonoid compounds in the echinacea purpurea-lactic acid bacteria leavening are beneficial to exerting the anti-oxidation and immune regulation effects of the echinacea purpurea-lactic acid bacteria leavening. Therefore, the composite acid gel provided by the invention is green, safe and non-irritant, the preparation method is simple and convenient, and the composite acid gel can be used for inhibiting bacteria and reducing scalp inflammation.

The invention provides a piezoelectric composite stent, a preparation method thereof and application of the piezoelectric composite stent in tracheal defect repair, and belongs to the technical field of tissue engineering. The preparation method of the piezoelectric composite stent comprises the following steps: (1) immersing a PLLA stent into an FF polypeptide solution to prepare a PLLA-FF stent; (2) the PLLA-FF stent is immersed in a tannic acid solution, and a PLLA-FF-TA composite stent is prepared; (3) preparing oxygen-containing PLGA (poly (lactic-co-glycolic acid)) nano microbubbles, and mixing the GelMA with the oxygen-containing PLGA nano microbubbles to obtain a Gel-NB hydrogel precursor; (4) injecting the Gel-NB hydrogel precursor into the PLLA-FF-TA composite scaffold, and carrying out ultraviolet light cross-linking on the Gel-NB hydrogel precursor and the PLLA-FF-TA composite scaffold; and carrying out ultrasonic irradiation to obtain the PLLA-FF-TA (at) Gel-Nb + US composite scaffold. The piezoelectric hydrogel stent is successfully prepared, can be well used for tracheal defect repair, has the advantages of good degradation performance, high piezoelectric performance, long-term stability and high strength, and is beneficial to clinical transformation and application.

The invention relates to the field of biodegradation, and discloses a full-biodegradable composite film as well as a preparation method and application thereof. The composite film comprises a barrier layer, a protective layer and a bonding layer, the protective layer is arranged on the surface layer of the composite film, and the barrier layer and the protective layer are bonded through the bonding layer; matrix resin B of the bonding layer is selected from degradable resin grafted polar monomers and / or degradable resin grafted monomers containing groups capable of reacting with hydroxyl; the matrix resin C of the barrier layer at least contains polyglycolic acid with multimodal molecular weight distribution. The composite film provided by the invention has excellent barrier property and biodegradability, and also has good interlayer peel strength and heat sealing strength.

The invention discloses a multi-layer sustained-release microsphere with an anti-wrinkle effect as well as a preparation method and application of the multi-layer sustained-release microsphere. The multilayer sustained release microsphere provided by the invention is prepared from the following components in percentage by weight: 5 to 15 percent of alligator oil, 65 to 80 percent of polylactic acid-glycolic acid copolymer (PLGA), 5 to 15 percent of chitosan and 0.1 to 5 percent of natural antioxidant. The multi-layer sustained release microsphere sequentially comprises an alligator oil-PLGA core sphere, a natural antioxidant-PLGA middle layer and a chitosan outer layer from inside to outside. The multilayer sustained-release microsphere prepared by adopting an electrostatic spinning technology has a porous multilayer structure, can realize accurate sustained release of different active components in each layer, prolongs the duration of a repairing effect, effectively reduces a burst release effect, and can ensure the stability of each active substance through layering treatment among the active substances, so that the stability of the active substances is improved. All the layers are released according to a specific rate and synergistically act on the skin, so that the utilization rate of active ingredients can be increased, waste is reduced, and meanwhile, the irritation risk to the skin is also reduced.

The invention provides a preparation method of a catalyst for preparing glycollic acid by oxidizing ethylene glycol, which comprises the following steps: impregnating a carrier in an impregnation liquid containing active metal salt, auxiliary metal salt and a polyhydroxy compound in equal volume, drying, roasting and reducing to obtain the catalyst for preparing glycollic acid by oxidizing ethylene glycol, wherein the active metal salt is selected from Pt salt and Pd salt, or Pt salt and Ru salt; the auxiliary metal salts are selected from any two of Sn, Ce, Ga, Bi, La, Mn and Rb salts; the carrier is a mixture of a mesoporous molecular sieve and an amorphous inorganic porous material. The catalyst prepared by the method can be used for preparing glycollic acid by high-activity and high-selectivity oxidation of ethylene glycol under mild, green and alkali-free conditions under the condition of low catalyst dosage.

The invention belongs to the field of chemistry and chemical engineering, and discloses a method for preparing high-purity 1, 4-dioxane-2-ketone at low cost. A large amount of high-purity 1, 4-dioxane-2-ketone can be prepared at one time by taking a large amount of glycollic acid or glycollic acid derivatives and ethylene oxide as raw materials and adopting a one-step synthesis process route and a purification mode suitable for industrial production. According to the method, cheap bulk commodities are adopted as raw materials, and high-value conversion of low-value chemicals is achieved; according to the method disclosed by the invention, the 1, 4-dioxane-2-ketone is rapidly synthesized in one step under mild conditions without a catalyst or with a trace amount of a catalyst, so that the synthesis yield of a target product is improved, the reaction steps are greatly shortened, the energy consumption is greatly reduced, and the production cost is obviously reduced.

The invention discloses bioactive macroporous hydrogel as well as a preparation method and application thereof. The bioactive macroporous hydrogel comprises hydrogel particles and a bioactive load loaded on the hydrogel particles, the hydrogel particles are obtained by mechanically extruding a hydrogel matrix, and the hydrogel matrix is formed by compounding sodium alginate, agarose and methacrylated hyaluronic acid through hydrogen bond crosslinking and photo-crosslinking; the bioactive load comprises: a) small extracellular vesicles of which the surfaces are modified with macrophage targeted CRV peptides; and b) a PLGA (poly (lactic-co-glycolic acid)) microsphere loaded with a cartilage inducer Kartogenin. The bioactive macroporous hydrogel disclosed by the invention has an internally communicated macroporous network, is beneficial to cell infiltration, blood vessel ingrowth and nutrient substance diffusion, and overcomes the defects that the traditional hydrogel is small in pore size and limits cell behaviors. According to the bioactive macroporous hydrogel disclosed by the invention, dual bioactive loads are adopted to synergistically promote tendon-bone healing, so that the treatment effect is better.

The invention discloses an artificial bone for promoting osteoporotic bone defect repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The artificial bone disclosed by the invention is prepared by compounding the following components in percentage by weight: 89.65 to 89.85 weight percent of polylactic acid-glycolic acid copolymer, 9.85 to 10.15 weight percent of nano hydroxyapatite and 0.1 to 0.5 weight percent of zoledronic acid. In the artificial bone, the nano-hydroxyapatite and zoledronic acid are uniformly dispersed in the polylactic acid-glycolic acid copolymer, and the porous structure on the surface of the artificial bone is combined, so that osteoblasts can be attached to the surface of the artificial bone, and new bone tissues can grow in the artificial bone; phosphonate radicals of zoledronic acid can be chelated with nano-hydroxyapatite to generate stable chemical bonds, the stable chemical bonds are introduced into the polylactic acid-glycolic acid copolymer, effective loading of zoledronic acid can be achieved, and the effective loading of zoledronic acid can inhibit bone resorption increase caused by overactivation of osteoclasts and repair osteoporotic bone defects.

The invention relates to the technical field of biomedicine, and discloses a triclosan antibacterial coating surgical suture and a preparation method thereof.The suture comprises a base material and a surface antibacterial coating, the base material is selected from one of an absorbable single-strand material, an absorbable multi-strand material, a non-absorbable single-strand material and a non-absorbable multi-strand material, and the surface antibacterial coating is selected from one of an absorbable multi-strand material and a non-absorbable multi-strand material; the antibacterial coating comprises triclosan, a high-molecular carrier and an auxiliary agent, the surface energy of a hydrophobic material is improved, the porosity of a hydrophilic material is increased, the adhesive force between the coating and different base materials is ensured, the base materials can be covered, the uniformity deviation of the coating is avoided, and the coating is free of cracking or falling off through the combination of plasma cleaning and roughening treatment on the surface of the base materials. A synergistic system is formed by triclosan, nano-silver and titanium dioxide, a dual mechanism of targeted destruction of bacterial cell membranes and free radical oxidation is achieved, the antibacterial rate is increased, the MRSA inhibition rate is increased, the degradation rate is regulated and controlled through the polylactic acid-glycolic acid copolymer carrier molecular weight and the lactic acid / glycolic acid proportion, and a curing dynamic formula is combined.

The invention relates to the technical field of breathable adhesive tapes, in particular to a double-layer composite high-breathability low-sensitivity adhesive tape and a preparation method thereof. The adhesive tape comprises a hydrophobic surface layer material, a high-breathability low-sensitivity composite adhesive and release paper. The high-breathability and low-sensitivity adhesive tape comprises a three-dimensional net-shaped breathable layer and a low-sensitivity adhesive layer. The hydrophobic surface layer material adopts a polyvinylidene fluoride electrostatic spinning nanofiber membrane with high specific surface area and porosity, so that the hydrophobicity and the adhesion with the lower layer material are improved; according to the high-breathability and low-sensitivity adhesive tape, polycaprolactone, a polylactic acid-glycolic acid copolymer and polyurethane are copolymerized to obtain a multifunctional three-dimensional net-shaped breathable layer; the high-breathability and low-sensitivity composite adhesive tape is prepared from dopamine modified polydimethylsiloxane microfibers decorated by oxidized dextran modified vinyl siloxane tip fibers, and the adhesive force and biocompatibility of the adhesive tape and skins with different roughness degrees are enhanced. Meanwhile, the lignosulfonate surfactant is added, so that the reproduction of bacteria and fungi in an adhesive tape attachment area can be inhibited.

The invention relates to low-temperature lead-free formic acid solder paste and a preparation method and application thereof, and belongs to the technical field of welding materials. The low-temperature lead-free formic acid solder paste is prepared from the following raw materials in percentage by mass: 85-90% of alloy welding powder and 10-15% of scaling powder, the soldering flux comprises the following raw materials in parts by weight: 10-15 parts of an activating agent, 1-5 parts of a rheological agent, 20-30 parts of an organic solvent, 20-30 parts of a paste forming agent, 3-5 parts of a surfactant and 0.1-0.5 part of a corrosion inhibitor, the activating agent is a composition of hydrogenated dimer acid, glycollic acid and ethylenediaminetetraacetic acid, and the organic solvent is a composition of tetrahydrofurfuryl alcohol and cyclohexanol. The paste forming agent is polyethylene glycol. The solder paste is suitable for a low-temperature welding process at the temperature of 120-150 DEG C, welding energy consumption can be reduced, the residual rate after welding is low, follow-up cleaning is not needed, the production environment can be improved, and the production cost can be reduced.

The invention discloses escherichia coli recombinant bacteria with high glycolic acid yield and a construction method of the escherichia coli recombinant bacteria, and belongs to the technical field of bioengineering. Lactate dehydrogenase ldhA, phosphate transacetylase pta, acetokinase ackA and pyruvate oxidase poxB are knocked out in escherichia coli, key enzymes isocitrate lyase aceA and glyoxylate reductase ghrA in a glycollic acid synthesis path are over-expressed in a genome level, conversion of carbon flow to glycollic acid is enhanced, and the glycolic acid is converted into glycolic acid. On the basis, malic acid synthase AaceB, malic acid synthase GglcB and glycollic acid oxidase glcDEF are knocked out, a branch metabolic pathway is blocked, an efficient strain which is free of plasmids and resistance genes and does not need to induce glycollic acid production is constructed, the accumulation amount of L-valine fermented in a 5L fermentation tank for 48 hours reaches 51.2 g / L, the yield is 0.6 g / g, and the production intensity is 1.06 g / L / h.

The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.

The invention discloses an antihypertensive material for subcutaneous implantation and a preparation method of the antihypertensive material, and belongs to the technical field of biomedical materials. The antihypertensive material comprises a carrier material and a drug mixture loaded on the carrier material according to a mass ratio of (10-15): (5-8), and the carrier material comprises the following raw materials: polylactic acid-glycolic acid copolymer, citric acid-chitosan ester, genipin and a silicon dioxide active material. The silicon dioxide active material is obtained by compounding mesoporous silicon dioxide nanoparticles and a collagen coating on the surface of the mesoporous silicon dioxide nanoparticles. According to the antihypertensive material disclosed by the invention, a degradable skeleton is provided by the polylactic acid-glycolic acid copolymer, citric acid-chitosan ester is used as a toughening agent and an antibacterial material, genipin is used as a cross-linking agent, and a mesoporous structure of a silicon dioxide active material is used for loading a medicine; the problems that an existing subcutaneous implant material is high in burst release rate, poor in mechanical property, insufficient in biocompatibility and the like are solved.

The invention relates to the technical field of wound care, in particular to a responsive release microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, dissolving a polylactic acid-glycolic acid copolymer in an organic solvent, adding an emulsifier, and carrying out ultrasonic emulsification to form a water-in-oil emulsion; s2, mixing a polyphenol compound, elastin, vegetable fat and probiotic suspension to form a quaternary mixed solution, slowly dropwise adding the quaternary mixed solution into the water-in-oil emulsion, continuing ultrasonic emulsification to form multiple emulsion, and evaporating to remove an organic solvent to obtain a quaternary system active component mixed solution; and S3, dissolving PDMAEMA in deionized water, adding a cross-linking agent, stirring, slowly dropwise adding the quaternary system active component mixed solution, carrying out a cross-linking reaction, and freeze-drying to obtain the responsive release microcapsule. The microcapsule can accurately release corresponding active ingredients according to pH value changes in different stages of wound healing, effectively shorten the wound healing time, improve the healing quality and reduce scar formation.

The present disclosure relates to the technical field of microsphere drug preparations, in particular to an octreotide acetate sustained-release microsphere as well as a preparation method therefor and use thereof. The preparation method includes the following steps: S1, dissolving a polylactic acid-co-glycolic acid copolymer in a first organic solvent to prepare an oil phase 1; and dissolving octreotide acetate in a second organic solvent to prepare an oil phase 2; S2, adding the oil phase 2 into the oil phase 1 under stirring conditions to obtain a suspension containing octreotide acetate; S3, transferring the suspension to an aqueous phase, and performing emulsifying to obtain a semi-cured drug-loaded microsphere; and S4, transferring the semi-cured drug-loaded microsphere to a curing phase, and removing the solvents to obtain the octreotide acetate sustained-release microsphere.

The invention relates to the field of skincare products, and particularly discloses skincare gel loaded with ganoderma lucidum exosome and a preparation method of the skincare gel. The skin care gel loaded with the lucid ganoderma exosome is prepared from the following raw materials in parts by weight: 20 to 40 parts of hydrogel matrix, 2 to 4 parts of lucid ganoderma exosome nanoparticles, 2 to 6 parts of niobium carbide nanosheets, 1 to 3 parts of nicotinamide, 0.1 to 2 parts of phenethyl resorcinol and 0.1 to 3 parts of green tea extract, the Mailing exosome nanoparticles are of a core-shell structure, a core layer comprises Mailing exosome and papain in a mass ratio of 1: (0.1-0.2), and a shell layer comprises a polylactic acid-glycolic acid copolymer and a penetration enhancer in a mass ratio of 1: (0.1-0.3). The skin-care gel provided by the invention has remarkable whitening, moisturizing and skin brightening effects.

The invention belongs to the technical field of drug delivery, and particularly relates to an M-coated PLGA-10BX compound as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing 10B-enriched boron nitride (h-10BN); extracting a cell membrane of the macrophage RAW264.7; polylactic acid-glycolic acid copolymer (PLGA) nano particles loaded with h-10BN are prepared; and finally, the bionic nano platform M (at) PLGA-10BN based on the macrophage membrane is prepared. The bionic nano-platform prepared by the invention is uniform in particle size and morphology, has relatively high biological safety, and has no obvious damage to various tissues and visceral organs. The compound can be used as a general platform for boron compound delivery, can also be used as an immune activator, is suitable for intravenous injection administration, and expands the application of boron neutron capture therapy (BNCT) in treatment of glioblastoma (GBM).

The invention discloses a neutral organic chelating cleaning agent for a boiler, and belongs to the field of chemical cleaning of boiler superheaters of thermal power plants. The cleaning agent is prepared from the following components in percentage by weight: 0.5%-5% of ethylenediamine tetraacetic acid ammonium, 0.1%-4% of acetic acid or ammonium acetate, 0.1%-3% of glycollic acid ammonium or glycollic acid, 0.1%-5% of a pH regulator, 0.1%-1% of a cosolvent, 0.2%-0.8% of a corrosion inhibitor SH369, 0.1%-0.6% of a reducing agent, 0.0%-0.3% of a defoaming agent, 0.0%-0.2% of a surfactant and 84%-93% of water, wherein the pH value of the cleaning agent is 6-8; the cosolvent is tartaric acid and / or hydroxybutyl diacid, the surfactant is nonylphenol polyoxyethylene ether, and the reducing agent is hydrazine. The cleaning agent disclosed by the invention has good dissolving capacity on oxide skin, does not generate precipitates to cause pipe blockage, is a neutral solution, is very small in corrosivity, does not generate intergranular corrosion, is beneficial to protecting various pipes of superheaters and reheaters, and is a safe and efficient superheater cleaning agent.

The invention provides an antistatic derusting neutralizing acid agent and a preparation method thereof, and belongs to the technical field of commercial cleaning. The antistatic derusting neutralizing acid agent provided by the invention comprises the following components in percentage by mass: 2.0-6.0% of an antistatic agent which is Gemini-type quaternary ammonium salt, 2.0-6.0% of an anti-rust agent, 2.0-6.0% of a neutralizing agent and the balance of water. 15.5-41.0% of a composite acid agent, wherein the composite acid agent is methanesulfonic acid, glycollic acid and ammonium bifluoride; 1.0 to 5.0 percent of chelating agent, wherein the chelating agent is a strong acid resistant chelating agent; 0.5 to 2.0 percent of corrosion inhibitor; and the balance of water. The antistatic derusting neutralizing acid agent provided by the invention has excellent antistatic performance, and can efficiently improve the antistatic performance of linen at low cost when being used in a neutralizing treatment stage of the linen.

The invention discloses a frontalon tooth healing targeting nano preparation and a preparation process thereof, belongs to the technical field of nano medicines, and aims to solve the problems that the natural regeneration capacity of teeth is limited and the combination of ethnic drugs and modern biotechnology is caused due to the lack of a targeting inhibition means for USAG-1. Comprising an anti-USAG-1 monoclonal antibody, ethnic drug components and a nano-carrier, the anti-USAG-1 monoclonal antibody is connected to the surface of the nano-carrier through covalent bonds, the ethnic drug components are loaded in the nano-carrier through physical action, and the nano-carrier is a polylactic acid-glycolic acid copolymer or chitosan; the anti-USAG-1 monoclonal antibody is used as a targeting ligand, is high in targeting property, can accurately reach a tooth focus, improves the drug utilization rate, enhances the curative effect, integrates multiple ethnic drug components, exerts a synergistic effect, can increase the contact area between the ethnic drug components and a biological membrane, promotes the absorption and transport of the drug, and improves the bioavailability of the drug. And the medicine can better play a treatment role.

The present invention discloses an oxidation catalyst, a preparation method thereof and an application thereof. The oxidation catalyst comprises a carrier and an active component supported on the carrier; the carrier is Sb6O 13 , and the active component is PdO. The oxidation catalyst has more oxygen vacancies, exhibits excellent catalytic oxidation performance, and can catalyze the selective preparation of glycolic acid from ethylene glycol. At the same time, the preparation method of the oxidation catalyst is simple and convenient, green and environmentally friendly, and can realize the efficient conversion of ethylene glycol to glycolic acid without adding an external base, reducing the degree of environmental pollution and having broad application prospects.

The invention discloses a degradable nanocellulose sustained-release drug-loaded film and a preparation method thereof, and belongs to the technical field of drug functional materials. The preparation method comprises the following steps: mixing and stirring microcrystalline cellulose and 64wt% sulfuric acid solution, centrifuging, dialyzing to be neutral, and freeze-drying to obtain CNCs; cNCs, NaIO4 and water are mixed and then subjected to a light-shielding reaction, ethanol precipitation is added, dialysis purification is conducted, freeze drying is conducted, and formylation modified CNCs are obtained; mixing and stirring the aldehyde modified CNCs, sericin, polyvinyl alcohol, water and a target drug to obtain a core layer solution; dissolving a polylactic acid-glycolic acid copolymer into a mixed solution of chloroform and DMF (Dimethyl Formamide) to obtain a shell solution; the core layer solution and the shell layer solution are subjected to coaxial electrostatic spinning forming to obtain the drug-loaded fiber, then the drug-loaded fiber is subjected to biomimetic mineralization surface modification to obtain the degradable nanocellulose sustained-release drug-loaded film, the drug loading rate is increased, the mechanical property of the drug-loaded film is improved, and the sustained-release and release-controllable effects are achieved.

The invention relates to a polyacid composite oil-controlling and acne-removing gel and a preparation method thereof, and belongs to the technical field of skin care products. The polyacid composite oil-controlling and acne-removing gel is prepared from the following components in percentage by mass: 2% of salicylic acid, 3%-4% of glycolic acid, 0.5%-1.5% of mandelic acid, 0.5%-1.0% of lactobionic acid, 0.5%-1.0% of gluconolactone, 1.2%-1.6% of microcrystalline cellulose (and) sphingomonas fermentation product extract (and) cellulose gum, 2%-5% of butanediol, 0.3%-0.5% of asiaticoside-II, 0.5%-1.5% of centella asiatica, 0.5%-1.5% of vitamin E and the balance of water. And the balance of deionized water. By adding micro-crystalline cellulose (and) sphingomonas fermentation extract (and) cellulose gum, system stability under compounding of five organic acids is realized, semitransparent gelatinous texture is obtained, the composition is suitable for point coating use mode, impression is not affected, oil-controlling and acne-removing effects are improved under the condition of low organic acid content, and the composition belongs to skin-care polyacid products and has a broad market prospect. The mild oil control and acne removal effects are realized, and the cream is suitable for oil-sensitive skin crowds.

The invention relates to the technical field of medical gel, and particularly discloses a sustained-release gel preparation for endometrial repair and a preparation method of the sustained-release gel preparation. Keratinocyte factor sustained-release microspheres containing keratinocyte factor-glucan particles and lactic acid-glycolic acid copolymer shells are constructed around keratinocyte factors, and the keratinocyte factor sustained-release microspheres are loaded by hyaluronic acid hydrogel containing polylysine, collagen and silk fibroin to form the sustained-release gel preparation for endometrial repair. The sustained-release gel preparation has the effect of promoting proliferation of human endometrial cells, can repair endometrial injury, promote injury healing and prevent uterine cavity adhesion, and has important significance in treating endometrial injury and improving physical and psychological health of women.

The invention discloses a carbon quantum dot oil displacement agent with a slow release function and a preparation method thereof, and relates to the technical field of petrochemical industry. The carbon quantum dot oil displacement agent with the slow release function is marked as a solution C, the solution C comprises a solution A and a solution B, the solution A comprises glucose, lauryl amine and deionized water, the solution B comprises a polylactic acid-glycolic acid copolymer and dichloromethane, and the solution C is prepared by stirring and distilling the solution A and the solution B, and the solution C also internally comprises nonylphenol polyoxyethylene ether and a glutaraldehyde solution. According to the carbon quantum dot oil displacement agent, the interfacial activity and nano permeability of the carbon quantum dots are combined with the slow release and protection functions of the microcapsules, the advantages of high stability, slow release and controlled release, efficient oil displacement and environment friendliness are achieved, the carbon quantum dot oil displacement agent can adapt to complex oil reservoir conditions, the oil displacement efficiency and the recovery efficiency can be improved, and the oil displacement effect is good. The method has remarkable technical advantages and wide application prospects.

The present invention discloses drug-loaded nanoparticles targeting neuraminidase, as well as a preparation method and application thereof, belonging to the technical field of pharmaceutical preparations. The present invention connects polysialic acid and polylactic acid glycolic acid via an ester bond to obtain drug-loaded nanoparticles with stable structure and performance. The drug-loaded nanoparticles have the function of targeting neuraminidase and have relatively high efficiency in entering cells. Furthermore, antibiotics are dispersed in the drug-loaded nanoparticles, and an inflammatory modulator is adsorbed on the surface of the drug-loaded nanoparticles. The drug-loaded nanoparticles can deliver the antibiotics and the inflammatory modulator to Grasseria suis in pigs, releasing the antibiotics and the inflammatory modulator in the slightly acidic environment of the infected site in the pig, thereby efficiently killing Grasseria suis and reducing inflammatory damage caused by bacterial infection and toxic damage of the antibiotics. Therefore, the present invention has good application prospects in the preparation of drugs for preventing and / or treating Grasseria suis infection.