1131 results about "Glycolic acid" patented technology

The invention discloses an absorbable suture line for surgical suture and a preparation method thereof, and relates to the technical field of medical materials. The absorbable suture line for surgical suture is prepared from the following raw materials in parts by weight: 50 to 65 parts of polylactic acid, 15 to 20 parts of polyglycolic acid, 3 to 5 parts of sodium carboxymethyl cellulose, 3 to 8 parts of a toughening agent, 3 to 6 parts of an antibacterial agent, 0.3 to 0.8 part of a lubricating agent, 1 to 2 parts of sodium hyaluronate and 5 to 10 parts of polyvinyl alcohol. The toughening agent is obtained by reacting hydroxyethyl acrylate with ethylenediamine to generate a four-arm compound and then reacting with 6-caprolactone and DL-lactide. The absorbable suture line for surgical suture prepared by the invention has excellent tensile property and antibacterial property, and can meet the application requirements of clinical medical treatment.

The invention discloses a neuraminidase-targeted drug-loaded nanoparticle as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. Polysialic acid and poly (lactic-co-glycolic acid) are connected through ester bond connection to obtain the drug-loaded nanoparticles with stable structure and performance, and the drug-loaded nanoparticles have the effect of targeting neuraminidase and also have high efficiency of entering cells; the antibiotic drug is further dispersed in the drug-loaded nanoparticles, the inflammation regulating agent is adsorbed on the surface of the drug-loaded nanoparticles, and the drug-loaded nanoparticles can deliver the antibiotic drug and the inflammation regulating agent to the pig Gleisseria in the pig body. According to the present invention, the antibiotic drug and the inflammation regulating agent are released under the acidic environment at the infection site in the pig body, such that the pig Gleisseria is efficiently killed, the inflammation damage caused by bacterial infection and the toxic damage of the antibiotic drug are reduced, and the good application prospect is provided in the preparation of the drug for preventing and / or treating the pig Gleisseria infection.

The invention relates to the field of sponge materials, and provides an antibacterial degradable sponge material and a preparation method thereof. The material is prepared from protocatechuic acid modified quaternized chitosan, quaternary ammonium salt grafted gelatin, sodium alginate, polyhydroxybutyrate, polycaprolactone, a polylactic acid-glycolic acid copolymer, hexamethylene diisocyanate, a foaming agent, nano cellulose, vitamin E, polyethylene glycol, triethylamine and dimethylformamide. Protocatechuic acid and quaternized chitosan are subjected to amidation modification, and chitosan and gelatin are subjected to quaternization treatment by adopting 2, 3-epoxypropyl trimethyl ammonium chloride, so that the antibacterial property and biodegradability of the material are improved. In the material preparation process, through vacuum degassing, foaming vacuum degree and humidity control and a multi-step drying process, it is ensured that the average pore size of the material is uniform (50-200 microns) and the porosity is high (50%-90%), and the obtained material has excellent antibacterial property and degradability and has wide application value.

The invention relates to an oral mucosa repairing medicine and a preparation method thereof, and belongs to the technical field of medicines, the medicine comprises barnacle peptide, salivary lactobacillus, resveratrol, a biphasic adhesion matrix, hydroxyapatite, vitamin B family and other components. The preparation method comprises the following steps: sequentially carrying out enzymolysis on barnacle gooseneck by pepsin and lumbrukinase to obtain barnacle peptide. The double-phase adhesion matrix comprises a water-phase matrix, an oil-phase matrix and lecithin; the water-phase matrix contains a chondroitin sulfate-chitosan quaternary ammonium salt compound, sodium alginate and other components; the oil-phase matrix comprises sesame oil, beeswax, a polylactic acid-glycolic acid copolymer and the like. According to the invention, barnacle peptide and salivary lactobacillus are prepared by adopting a special method and are matched with resveratrol for use, so that multi-target and multi-path promotion of oral mucosa repair can be realized; the chondroitin sulfate-chitosan quaternary ammonium salt compound is prepared through electrostatic and physical embedding, the chondroitin sulfate-chitosan quaternary ammonium salt compound is matched with other components to prepare the biphasic adhesion matrix, the biocompatibility is good, the adhesion is high, and the action time of a sustained-release drug is well prolonged.

The invention belongs to the technical field of veterinary preparations, and particularly relates to a tilmicosin premix and a preparation method thereof. The tilmicosin premix is prepared from the following raw materials: tilmicosin, a polylactic acid-glycolic acid copolymer, lecithin, modified hydroxypropyl methyl cellulose, grafted polyvinylpyrrolidone, polyethylene glycol and an antioxidant, a solid dispersion is formed through lecithin and grafted polyvinylpyrrolidone, the solubility and stability of tilmicosin are enhanced, polylactic acid-glycolic acid copolymer nano-microspheres are prepared through a double-emulsion solvent evaporation method, slow release of drugs is achieved, dodecyl modified hydroxypropyl methyl cellulose and polyethylene glycol are combined, and the sustained release effect is achieved. The solubility and the slow release characteristic are further enhanced. The activity of the granular premix is effectively preserved, and the granular premix is convenient to use and transport.

The invention discloses a recycling method of polyethylene glycol terephthalate (PET). According to the method, organic acid is used as a catalyst for hydrolysis of PET, the organic acid is selected from one or more of adipic acid, lactic acid and glycollic acid, and then hydrolysis products are directly polymerized with additional monomers and polymerization catalysts to prepare the biodegradable copolyester without any separation treatment step. The prepared copolyester has biodegradability, so that the non-degradable PET is converted into the biodegradable copolyester by the recycling method, and the recycling method has important significance for relieving the problem of environmental pollution.

The invention discloses construction and application of an oral gel drug delivery system based on a yeast microcapsule, and belongs to the field of new auxiliary materials and new dosage forms of pharmaceutical preparations, the drug delivery system is composed of budesonide nanoparticles, the yeast microcapsule and gel, budesonide nanoparticles are prepared from budesonide and a polylactic acid-glycolic acid copolymer through a water-in-oil emulsification evaporation technology, yeast cell wall microcapsules are formed after content of yeast powder is removed, and the budesonide-loaded yeast microcapsules are prepared from the yeast microcapsules and the budesonide nanoparticles through stirring, ultrasonic treatment and freeze drying methods. The yeast cell wall microcapsule without contents is used as a carrier, so that the medicine is protected from being degraded by gastric acid, and the intestinal immune response is regulated by targeting intestinal related lymphatic tissues (GALT). The gel prepared by combining pectin can prolong the residence time of the drug in the intestinal tract, realizes continuous release, reduces the whole-body side effect of budesonide, and improves the treatment efficiency.

The invention relates to the technical field of dental restoration materials, in particular to a bacteriostatic dental restoration composite film and a preparation method thereof. The oral cavity restoration composite film is composed of an upper-layer antibacterial film, a middle-layer polycaprolactone fiber film and a lower-layer bone restoration film. The upper-layer antibacterial film is prepared from the following components in parts by weight: 3 to 4 parts of cinnamon essential oil, 0.5 to 1 part of xanthan gum, 0.5 to 1 part of seed meal protein, 0.1 to 0.15 part of tannic acid, 5 to 7 parts of silk fibroin, 1 to 1.5 parts of polylactic acid, 0.6 to 1 part of chitosan, 1 to 1.5 parts of polyvinyl alcohol and 1.5 to 2.5 parts of glycerol; the lower-layer bone repair membrane is prepared from the following raw materials in parts by weight: 2 to 3 parts of nano-hydroxyapatite, 3 to 5 parts of citric acid, 6 to 9 parts of lactic acid, 3 to 4 parts of tyrosine, 1 to 2 parts of glycollic acid, 2 to 3 parts of casein, 0.2 to 0.3 part of hyperoside and 1 to 2 parts of gelatin.

The invention relates to an antibacterial fabric and a preparation process thereof, and relates to the technical field of fabrics. The antibacterial fabric comprises a fabric body, the fabric body is formed by weaving polyester fibers, an antibacterial fiber membrane layer is arranged on the fabric body, and a preparation method of the antibacterial fiber membrane layer comprises the following steps that honokiol is added into a hexafluoroisopropanol solution and stirred to be uniform, then a polylactic acid-glycolic acid copolymer is added and stirred to be uniform, and the antibacterial fiber membrane layer is obtained. Preparing an antibacterial fiber membrane layer through electrostatic spinning equipment; the antibacterial fabric has the effect of improving the antibacterial property of the fabric.

The invention discloses a method for preparing a fully degradable hydrophilic / hydrophobic double-layer nanofiber membrane based on an electrostatic spinning method. The preparation method comprises the following steps: selecting a degradable high polymer material, taking hexafluoroisopropanol as a solvent, preparing a hydrophilic layer spinning solution from polylactic acid-glycolic acid copolymer (PLGA), methoxypolyethylene glycol (mPEG) and carbon dots (CDs) with antibacterial and anti-inflammatory characteristics, preparing a hydrophobic layer spinning solution from polycaprolactone (PCL), preparing a hydrophilic layer spinning solution from the hydrophilic layer spinning solution, preparing a hydrophilic layer spinning solution from the hydrophobic layer spinning solution, and preparing a hydrophilic layer spinning solution from the hydrophilic layer spinning solution and the hydrophobic layer spinning solution; and preparing the hydrophilic / hydrophobic double-layer nanofiber membrane by adopting an electrostatic spinning machine. The preparation method is simple, and the prepared double-layer nanofiber membrane is uniform in fiber diameter distribution and good in hydrophilic / hydrophobic layer effect and has a good application prospect in the field of biology.

The invention belongs to the technical field of medicine preparation, and relates to PLGA gel used as an injectable long-acting local anesthesia medicine as well as application and a preparation method of the PLGA gel. The PLGA gel comprises the PLGA gel which is loaded with superparamagnetic Fe3O4 particles and a small molecule local anesthetic, namely, levobupivacaine (Levobupi). The PLGA hydrogel containing Fe3O4 and levobupivacaine can be used as an injectable long-acting local anesthesia medicine, and the hydrogel can be changed from liquid to solid after being injected into a living body, so that the release efficiency of the medicine is slowed down, and the local action time of the hydrogel is prolonged. In addition, the hydrogel can undergo a phase change from a solid state to a liquid state under magnetocaloric therapy (MHT), increase pore diameter, promote release of levobupivacaine, and provide enhanced pain relief in vivo. Compared with the prior art, the invention has the beneficial effects of simple synthesis and easy industrialization. The drug release rate is adjusted through the phase change of the hydrogel, super-long-acting analgesia is realized, and the analgesia time is gt; 20 days. The gel can be loaded with various local anesthesia drugs such as L-bupivacaine, and pain management can be carried out on various pain scenes clinically.

The invention belongs to the technical field of hair care products, and particularly relates to composite acid gel for scalp care and a preparation method thereof. Salicylic acid, glycolic acid, piroctone azelate olamine salt, echinacea purpurea-lactic acid bacteria yeast, an emulsifier and water are combined, wherein the echinacea purpurea-lactic acid bacteria yeast is prepared by performing enzymolysis on echinacea purpurea through bacillus subtilis protease and then performing aerobic fermentation with lactic acid bacteria. Salicylic acid, glycolic acid and azelaic acid in the composite acid gel are compounded, so that stimulation of salicylic acid is weakened, and the effect of dissolving hair follicle grease is reserved; glycolic acid and azelaic acid are added to accelerate keratin metabolism, regulate sebum secretion and create safe and healthy shielding for the scalp environment, and polysaccharide and flavonoid compounds in the echinacea purpurea-lactic acid bacteria leavening are beneficial to exerting the anti-oxidation and immune regulation effects of the echinacea purpurea-lactic acid bacteria leavening. Therefore, the composite acid gel provided by the invention is green, safe and non-irritant, the preparation method is simple and convenient, and the composite acid gel can be used for inhibiting bacteria and reducing scalp inflammation.

The invention provides a piezoelectric composite stent, a preparation method thereof and application of the piezoelectric composite stent in tracheal defect repair, and belongs to the technical field of tissue engineering. The preparation method of the piezoelectric composite stent comprises the following steps: (1) immersing a PLLA stent into an FF polypeptide solution to prepare a PLLA-FF stent; (2) the PLLA-FF stent is immersed in a tannic acid solution, and a PLLA-FF-TA composite stent is prepared; (3) preparing oxygen-containing PLGA (poly (lactic-co-glycolic acid)) nano microbubbles, and mixing the GelMA with the oxygen-containing PLGA nano microbubbles to obtain a Gel-NB hydrogel precursor; (4) injecting the Gel-NB hydrogel precursor into the PLLA-FF-TA composite scaffold, and carrying out ultraviolet light cross-linking on the Gel-NB hydrogel precursor and the PLLA-FF-TA composite scaffold; and carrying out ultrasonic irradiation to obtain the PLLA-FF-TA (at) Gel-Nb + US composite scaffold. The piezoelectric hydrogel stent is successfully prepared, can be well used for tracheal defect repair, has the advantages of good degradation performance, high piezoelectric performance, long-term stability and high strength, and is beneficial to clinical transformation and application.

The invention relates to the field of biodegradation, and discloses a full-biodegradable composite film as well as a preparation method and application thereof. The composite film comprises a barrier layer, a protective layer and a bonding layer, the protective layer is arranged on the surface layer of the composite film, and the barrier layer and the protective layer are bonded through the bonding layer; matrix resin B of the bonding layer is selected from degradable resin grafted polar monomers and / or degradable resin grafted monomers containing groups capable of reacting with hydroxyl; the matrix resin C of the barrier layer at least contains polyglycolic acid with multimodal molecular weight distribution. The composite film provided by the invention has excellent barrier property and biodegradability, and also has good interlayer peel strength and heat sealing strength.

The invention discloses a multi-layer sustained-release microsphere with an anti-wrinkle effect as well as a preparation method and application of the multi-layer sustained-release microsphere. The multilayer sustained release microsphere provided by the invention is prepared from the following components in percentage by weight: 5 to 15 percent of alligator oil, 65 to 80 percent of polylactic acid-glycolic acid copolymer (PLGA), 5 to 15 percent of chitosan and 0.1 to 5 percent of natural antioxidant. The multi-layer sustained release microsphere sequentially comprises an alligator oil-PLGA core sphere, a natural antioxidant-PLGA middle layer and a chitosan outer layer from inside to outside. The multilayer sustained-release microsphere prepared by adopting an electrostatic spinning technology has a porous multilayer structure, can realize accurate sustained release of different active components in each layer, prolongs the duration of a repairing effect, effectively reduces a burst release effect, and can ensure the stability of each active substance through layering treatment among the active substances, so that the stability of the active substances is improved. All the layers are released according to a specific rate and synergistically act on the skin, so that the utilization rate of active ingredients can be increased, waste is reduced, and meanwhile, the irritation risk to the skin is also reduced.

The invention provides a preparation method of a catalyst for preparing glycollic acid by oxidizing ethylene glycol, which comprises the following steps: impregnating a carrier in an impregnation liquid containing active metal salt, auxiliary metal salt and a polyhydroxy compound in equal volume, drying, roasting and reducing to obtain the catalyst for preparing glycollic acid by oxidizing ethylene glycol, wherein the active metal salt is selected from Pt salt and Pd salt, or Pt salt and Ru salt; the auxiliary metal salts are selected from any two of Sn, Ce, Ga, Bi, La, Mn and Rb salts; the carrier is a mixture of a mesoporous molecular sieve and an amorphous inorganic porous material. The catalyst prepared by the method can be used for preparing glycollic acid by high-activity and high-selectivity oxidation of ethylene glycol under mild, green and alkali-free conditions under the condition of low catalyst dosage.

The invention discloses a modified polylactic acid-glycolic acid copolymer composite material scaffold and a preparation method and application thereof, the polylactic acid-glycolic acid copolymer composite material scaffold has a porous structure, pores in the surface and the interior are communicated with each other, and the pore diameter from the surface to the interior is increased in a gradient manner; a metal organic framework material is loaded on the surface of the polylactic acid-glycolic acid copolymer composite material bracket. The printing stent of the modified polylactic acid-glycolic acid copolymer composite material stent has macroscopic macropores and microscopic pores at the same time, so that the surface roughness of the stent can be improved, the purpose of remarkably promoting stent cell adhesion is achieved, the specific surface area of the stent can be remarkably increased, and the stability of the stent is improved. The polylactic acid-glycolic acid copolymer is accelerated to degrade and release more acidic degradation products, so that the degradation of the polydopamine is accelerated, the release of the medicine embedded in the polydopamine is accelerated, and the problem of slow degradation of the polydopamine in vivo and in vitro is solved.

The invention belongs to the field of chemistry and chemical engineering, and discloses a method for preparing high-purity 1, 4-dioxane-2-ketone at low cost. A large amount of high-purity 1, 4-dioxane-2-ketone can be prepared at one time by taking a large amount of glycollic acid or glycollic acid derivatives and ethylene oxide as raw materials and adopting a one-step synthesis process route and a purification mode suitable for industrial production. According to the method, cheap bulk commodities are adopted as raw materials, and high-value conversion of low-value chemicals is achieved; according to the method disclosed by the invention, the 1, 4-dioxane-2-ketone is rapidly synthesized in one step under mild conditions without a catalyst or with a trace amount of a catalyst, so that the synthesis yield of a target product is improved, the reaction steps are greatly shortened, the energy consumption is greatly reduced, and the production cost is obviously reduced.

The invention discloses bioactive macroporous hydrogel as well as a preparation method and application thereof. The bioactive macroporous hydrogel comprises hydrogel particles and a bioactive load loaded on the hydrogel particles, the hydrogel particles are obtained by mechanically extruding a hydrogel matrix, and the hydrogel matrix is formed by compounding sodium alginate, agarose and methacrylated hyaluronic acid through hydrogen bond crosslinking and photo-crosslinking; the bioactive load comprises: a) small extracellular vesicles of which the surfaces are modified with macrophage targeted CRV peptides; and b) a PLGA (poly (lactic-co-glycolic acid)) microsphere loaded with a cartilage inducer Kartogenin. The bioactive macroporous hydrogel disclosed by the invention has an internally communicated macroporous network, is beneficial to cell infiltration, blood vessel ingrowth and nutrient substance diffusion, and overcomes the defects that the traditional hydrogel is small in pore size and limits cell behaviors. According to the bioactive macroporous hydrogel disclosed by the invention, dual bioactive loads are adopted to synergistically promote tendon-bone healing, so that the treatment effect is better.

The invention discloses an artificial bone for promoting osteoporotic bone defect repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The artificial bone disclosed by the invention is prepared by compounding the following components in percentage by weight: 89.65 to 89.85 weight percent of polylactic acid-glycolic acid copolymer, 9.85 to 10.15 weight percent of nano hydroxyapatite and 0.1 to 0.5 weight percent of zoledronic acid. In the artificial bone, the nano-hydroxyapatite and zoledronic acid are uniformly dispersed in the polylactic acid-glycolic acid copolymer, and the porous structure on the surface of the artificial bone is combined, so that osteoblasts can be attached to the surface of the artificial bone, and new bone tissues can grow in the artificial bone; phosphonate radicals of zoledronic acid can be chelated with nano-hydroxyapatite to generate stable chemical bonds, the stable chemical bonds are introduced into the polylactic acid-glycolic acid copolymer, effective loading of zoledronic acid can be achieved, and the effective loading of zoledronic acid can inhibit bone resorption increase caused by overactivation of osteoclasts and repair osteoporotic bone defects.

The invention relates to the technical field of biomedicine, and discloses a triclosan antibacterial coating surgical suture and a preparation method thereof.The suture comprises a base material and a surface antibacterial coating, the base material is selected from one of an absorbable single-strand material, an absorbable multi-strand material, a non-absorbable single-strand material and a non-absorbable multi-strand material, and the surface antibacterial coating is selected from one of an absorbable multi-strand material and a non-absorbable multi-strand material; the antibacterial coating comprises triclosan, a high-molecular carrier and an auxiliary agent, the surface energy of a hydrophobic material is improved, the porosity of a hydrophilic material is increased, the adhesive force between the coating and different base materials is ensured, the base materials can be covered, the uniformity deviation of the coating is avoided, and the coating is free of cracking or falling off through the combination of plasma cleaning and roughening treatment on the surface of the base materials. A synergistic system is formed by triclosan, nano-silver and titanium dioxide, a dual mechanism of targeted destruction of bacterial cell membranes and free radical oxidation is achieved, the antibacterial rate is increased, the MRSA inhibition rate is increased, the degradation rate is regulated and controlled through the polylactic acid-glycolic acid copolymer carrier molecular weight and the lactic acid / glycolic acid proportion, and a curing dynamic formula is combined.

The invention relates to the field of biological detection, in particular to fusion protein, a fluorescent probe and application thereof. The invention provides a fusion protein. The fusion protein comprises an acid-sensitive polypeptide, a circulating rearranged fluorescent protein and a connecting peptide, the amino acid sequence of the connecting peptide comprises one or more of LE, TR, SAG and GT. The fluorescent probe disclosed by the invention breaks through limitation of a traditional detection method, can realize rapid real-time quantitative glycollic acid detection, has good detection characteristics of high cost performance, simplicity and convenience in operation, rapid reaction, high specificity and the like, and is a user-friendly glycollic acid quantitative detection tool.

The invention relates to the technical field of breathable adhesive tapes, in particular to a double-layer composite high-breathability low-sensitivity adhesive tape and a preparation method thereof. The adhesive tape comprises a hydrophobic surface layer material, a high-breathability low-sensitivity composite adhesive and release paper. The high-breathability and low-sensitivity adhesive tape comprises a three-dimensional net-shaped breathable layer and a low-sensitivity adhesive layer. The hydrophobic surface layer material adopts a polyvinylidene fluoride electrostatic spinning nanofiber membrane with high specific surface area and porosity, so that the hydrophobicity and the adhesion with the lower layer material are improved; according to the high-breathability and low-sensitivity adhesive tape, polycaprolactone, a polylactic acid-glycolic acid copolymer and polyurethane are copolymerized to obtain a multifunctional three-dimensional net-shaped breathable layer; the high-breathability and low-sensitivity composite adhesive tape is prepared from dopamine modified polydimethylsiloxane microfibers decorated by oxidized dextran modified vinyl siloxane tip fibers, and the adhesive force and biocompatibility of the adhesive tape and skins with different roughness degrees are enhanced. Meanwhile, the lignosulfonate surfactant is added, so that the reproduction of bacteria and fungi in an adhesive tape attachment area can be inhibited.

The invention relates to low-temperature lead-free formic acid solder paste and a preparation method and application thereof, and belongs to the technical field of welding materials. The low-temperature lead-free formic acid solder paste is prepared from the following raw materials in percentage by mass: 85-90% of alloy welding powder and 10-15% of scaling powder, the soldering flux comprises the following raw materials in parts by weight: 10-15 parts of an activating agent, 1-5 parts of a rheological agent, 20-30 parts of an organic solvent, 20-30 parts of a paste forming agent, 3-5 parts of a surfactant and 0.1-0.5 part of a corrosion inhibitor, the activating agent is a composition of hydrogenated dimer acid, glycollic acid and ethylenediaminetetraacetic acid, and the organic solvent is a composition of tetrahydrofurfuryl alcohol and cyclohexanol. The paste forming agent is polyethylene glycol. The solder paste is suitable for a low-temperature welding process at the temperature of 120-150 DEG C, welding energy consumption can be reduced, the residual rate after welding is low, follow-up cleaning is not needed, the production environment can be improved, and the production cost can be reduced.

The invention discloses escherichia coli recombinant bacteria with high glycolic acid yield and a construction method of the escherichia coli recombinant bacteria, and belongs to the technical field of bioengineering. Lactate dehydrogenase ldhA, phosphate transacetylase pta, acetokinase ackA and pyruvate oxidase poxB are knocked out in escherichia coli, key enzymes isocitrate lyase aceA and glyoxylate reductase ghrA in a glycollic acid synthesis path are over-expressed in a genome level, conversion of carbon flow to glycollic acid is enhanced, and the glycolic acid is converted into glycolic acid. On the basis, malic acid synthase AaceB, malic acid synthase GglcB and glycollic acid oxidase glcDEF are knocked out, a branch metabolic pathway is blocked, an efficient strain which is free of plasmids and resistance genes and does not need to induce glycollic acid production is constructed, the accumulation amount of L-valine fermented in a 5L fermentation tank for 48 hours reaches 51.2 g / L, the yield is 0.6 g / g, and the production intensity is 1.06 g / L / h.

The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.

The invention discloses an antihypertensive material for subcutaneous implantation and a preparation method of the antihypertensive material, and belongs to the technical field of biomedical materials. The antihypertensive material comprises a carrier material and a drug mixture loaded on the carrier material according to a mass ratio of (10-15): (5-8), and the carrier material comprises the following raw materials: polylactic acid-glycolic acid copolymer, citric acid-chitosan ester, genipin and a silicon dioxide active material. The silicon dioxide active material is obtained by compounding mesoporous silicon dioxide nanoparticles and a collagen coating on the surface of the mesoporous silicon dioxide nanoparticles. According to the antihypertensive material disclosed by the invention, a degradable skeleton is provided by the polylactic acid-glycolic acid copolymer, citric acid-chitosan ester is used as a toughening agent and an antibacterial material, genipin is used as a cross-linking agent, and a mesoporous structure of a silicon dioxide active material is used for loading a medicine; the problems that an existing subcutaneous implant material is high in burst release rate, poor in mechanical property, insufficient in biocompatibility and the like are solved.

The invention discloses a novel process for producing a high-quality liquid fertilizer by using an acetylisovaleryltylosin tartrate finished product liquid, and relates to the technical field of fertilizer preparation, and the novel process comprises the following specific steps: step 1, firstly, weighing polyoxyethylene sorbitan fatty acid ester, ethylenediamine tetraacetic acid disodium salt, cellulase and protease, and uniformly stirring; the preparation method has the advantages that the polylactic acid-glycolic acid copolymer serving as a functional high-molecular polymer has good biocompatibility and controlled release performance, and when a solution prepared from the polylactic acid-glycolic acid copolymer is emulsified and mixed with an alginate oligosaccharide solution, a uniform emulsion-like active synergistic carrier solution is formed; the emulsifying and mixing process enables the effective components in the two solutions to be fully and uniformly combined together to form a stable microsphere and micelle structure, so that the continuous and slow release of the acetylisovaleryltylosin tartrate and the synergistic plant growth regulatory factors thereof in the growth cycle of crops can be ensured, the fertilizer effect of the acetylisovaleryltylosin tartrate and the synergistic plant growth regulatory factors thereof can be fully exerted, and the crop quality is improved. Therefore, the problem that the fertilizer efficiency is not obvious in the prior art is effectively solved.

The invention relates to the technical field of wound care, in particular to a responsive release microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, dissolving a polylactic acid-glycolic acid copolymer in an organic solvent, adding an emulsifier, and carrying out ultrasonic emulsification to form a water-in-oil emulsion; s2, mixing a polyphenol compound, elastin, vegetable fat and probiotic suspension to form a quaternary mixed solution, slowly dropwise adding the quaternary mixed solution into the water-in-oil emulsion, continuing ultrasonic emulsification to form multiple emulsion, and evaporating to remove an organic solvent to obtain a quaternary system active component mixed solution; and S3, dissolving PDMAEMA in deionized water, adding a cross-linking agent, stirring, slowly dropwise adding the quaternary system active component mixed solution, carrying out a cross-linking reaction, and freeze-drying to obtain the responsive release microcapsule. The microcapsule can accurately release corresponding active ingredients according to pH value changes in different stages of wound healing, effectively shorten the wound healing time, improve the healing quality and reduce scar formation.

The invention provides a tracer agent for an oil field and a method for evaluating oil production contribution of each section of a horizontal well, and belongs to the technical field of oil field development. The tracer agent for the oil field, provided by the invention, is prepared from white oil, a nonionic surfactant, 3-allyloxy-2-hydroxy propanesulfonic acid sodium salt and alcohols; wherein the rare earth metal salt, the complexing agent and the sodium 3-allyloxy-2-hydroxy propanesulfonate form a complex; the complexing agent is a mixture of glycolic acid, triethylene tetramine and sodium dimercaptopropanesulfonate in a mass ratio of 10: (3-5): (1-2). The tracer agent for the oil field can stably exist under complex stratum conditions and can resist hypersalinity; in the process of evaluating the oil production contribution of each section of the horizontal well by using the tracer agent for the oil field, different types and different dosages of tracer agents are selected for different layer sections, so that the evaluation of the oil production contribution of each section of the horizontal well can be realized, and an effective basis is provided for subsequent refracturing.