262 results about "Matrix composition" patented technology

A composition for controlled release of an opioid from a pharmaceutical composition, the method comprises controlling the release of at least one opioid into an aqueous medium by erosion of at least one surface of a pharmaceutical composition comprising I) a matrix composition comprising a) polymer or a mixture of polymers, b) an opioid and, optionally, c) one or more pharmaceutically acceptable excipients, and (i) a coating. The matrix composition has a conus-like shape so the surface area exposed to the aqueous medium increases at least during initial erosion of the matrix composition, and the dissolution of the opioid-when tested in a Dissolution Test as described herein with or without application of sinkers-results in a zero order release of at least 80% of the opioid contained in the composition. Such compositions are especially suitable for controlled release of an opioid to obtain a delayed pead concentration and a prolonged therapeutically effective plasma concentration upon oral administration. Once or twice daily administration is possible. The matrix typically comprises PEO and the active substance is typically an opioid such as morphine or a glucuronide thereof.

The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent.

Compositions, methods, and systems for manufacturing articles, particularly containers and packaging materials, having a highly inorganically filled matrix. Suitable inorganically filled mixtures are prepared by mixing together an organic polymer binder, water, one or more aggregate materials, fibers, and optional admixtures in the correct proportions in order to form an article which has the desired performance criteria. The inorganically filled mixtures are molded to fashion a portion of the mixture into a form stable shape for the desired article. Once the article has obtained form stability, such as by heating to remove water by evaporation, the article is removed from the mold and allowed to harden to gain strength. The articles may have properties substantially similar to articles presently made from traditional materials like paper, paperboard, polystyrene, plastic, or metal. They have especial utility in the mass production of containers, particularly food and beverage containers.

An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-β, BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions.

Described is an electrode comprising and preferably consisting of electronically active material (EAM) in nanoparticulate form and a matrix, said matrix consisting of a pyrolization product with therein incorporated graphene flakes and optionally an ionic lithium source. Also described are methods for producing a particle based, especially a fiber based, electrode material comprising a matrix formed from pyrolized material incorporating graphene flakes and rechargeable batteries comprising such electrodes.

A demineralized bone matrix (DBM) or other matrix composition is provided that has been stabilized by lowering the pH of the composition, reducing the water content, adding water substitutes, and/or increasing the amount of deuterated water present in the composition in order to reduce the activity of endogenous degrading enzymes such as proteases. A hydrated form of a stabilized DBM composition may be stable up to a year at room temperature at acidic pH. The acidified DBM compositions may be further stabilized by the addition of a stabilizing agent such as deuterated water, water substitutes, polymers, protease inhibitors, glycerol, hydrogels, etc. The invention also provides methods of preparing, testing, and using the inventive stabilized osteodinductive matrix compositions.

Compositions, methods, and systems for manufacturing articles, particularly containers and packaging materials, having a fiber-reinforced, starch-bound cellular matrix. Suitable mixtures used to form the articles are prepared by first preparing a viscous preblended mixture comprising water, a gelatinized starch-based binder, and fibers having an average length greater than about 2 mm. The highly viscous preblended mixture effectively transfers the shearing forces of the mixer to the fibers. The final moldable mixture is then prepared by mixing into the preblended mixture the remaining starch-based binder, water, and other desired admixtures, e.g., mold-releasing agents, inorganic filler rheology-modifying agents, plasticizers, coating materials, and dispersants, in the correct proportions to form an article which has the desired performance criteria. The moldable mixtures are heated between molds at an elevated temperature and pressure to produce form-stable articles having a desired shape and a selectively controlled foamed structural matrix. The articles may be manufactured to have properties substantially similar to articles presently made from conventional materials like paper, paperboard, polystyrene, plastic, or other organic-based materials and have especial utility in the mass-production of containers, particularly food and beverage containers.

A modified alkali silicate composition for forming an inorganic network matrix. The modified alkali silicate matrix is made by reacting an alkali silicate (or its precursors such as an alkali hydroxide, a SiO₂ source and water), an acidic inorganic composition, such as a reactive glass, water and optional fillers, additives and processing aids. An inorganic matrix composite can be prepared by applying a slurry of the modified aqueous alkali silicate composition to a reinforcing medium and applying the temperature and pressure necessary to consolidate the desired form. The composite can be shaped by compression molding as well as other known fabrication methods. A notable aspect of the invention is that, although composite and neat resin components prepared from the invention can exhibit excellent dimensional stability to 1000° C. and higher, they can be prepared at the lower temperatures and pressures typical to organic polymer processing.

A thin drywall board that includes a gel coat, at least one polymer/gypsum layer, and a wet glass fiber layer is provided. The gel coat is formed of a gel coat composition that includes a water dispersible polymer, gypsum, and optionally a crosslinking agent and/or a coupling agent. The polymer/gypsum layer is formed of a matrix composition that includes a water dispersible polymeric resin and gypsum. Components including melamine formaldehyde, a filler material, coupling agents, acetic acid, an accelerator, and/or a hardener may also be added to the matrix composition. The wet glass fiber layer is preferably a glass fiber mat. The combination of the water dispersible polymeric resin and the gypsum in the matrix composition have a synergistic effect that creates a thin drywall board that is water resistant, fire resistant, and has improved mechanical properties. A method of forming the inventive thin drywall boards is also provided.

A thermally conductive adhesive composition includes a powder of a high melting point metal or metal alloy, a powder of a low melting point metal or metal alloy, and a polymerizable fluxing polymer matrix composition having a polyepoxide polymer resin and a low-melting solid or liquid acid-anhydride and a polymer diluent or diluents with carbon carbon double bonds and/or functional hydroxyl groups. The ratio by weight of the low melting point powder to high melting point powder ranges from about 0.50 to about 0.80, and may range from about 0.64 to about 0.75, and may be 0.665. Heretofore unpredicted substantially higher thermal conductivity improvements in performance have been found using these ratios of low melting point powder to high melting point powder.

The invention provides a method for continuously producing particle reinforced metal matrix composites in an industrial scale, which adopts the synthesis of metal matrix composites in a combination magnetic field. The method is characterized in that: the combination of a rotating magnetic field and a travelling wave magnetic field is adopted to synthesize a preparation particle reinforced metal matrix composite fused mass in the in-situ synthesis process of composites. The low frequency rotating magnetic field is placed at the outer side of a composite material molten pool, and the center of a coil of the magnetic field and the center of the fused mass are at the same height; and the travelling wave magnetic field is exerted at the bottom part of the composite material molten pool, and the coil center of the travelling wave magnetic field and the center of the composite material molten pool are at the same position. The composite material particle reinforced phases prepared by the method are distributed evenly and thinned, interior tissues are compact and have no structural defects such as loosening and hole shrinkage, the degree of finish of external surfaces of casting blanks is high, defects are eliminated, and the friction resistance and the abrasion resistance of the composites are obviously improved.

The present invention provides a secured document including a composition capable of anti-Stokes fluorescence containing an ion capable of absorption of electromagnetic radiation, an ion capable of emitting electromagnetic radiation, and a matrix composition comprising gadolinium, yttrium, lanthanum, and luetium, wherein the wavelength of the emitted electromagnetic radiation is shorter than the wavelength of the absorbed electromagnetic radiation, and wherein the concentrations of the absorbing and emitting ions are adjusted to achieve concentration quenching of anti-Stokes luminescence.

The invention relates to a seedling raising substrate using cassava residue as a raw material and a preparation method thereof. The composition and weight percentage of the substrate are: cassava bagasse 40-70%, bagasse 10-30%, peat soil 10-20%, perlite 3-5%, superphosphate 1-2%, potassium chloride 0.2- 0.5%, 0.2-0.5% urea, pH 6-7, 5-10% starter; the starter is the pre-fermented product of cassava bagasse, bagasse, bran and microbial compound bacteria. This substrate is suitable for raising seedlings in nutritional cups and plug trays for vegetables, flowers, etc. It has excellent physical properties, excellent porosity, early, uniform and strong seedlings, suitable particle size composition, and good agglomeration performance. Cassava residue does not need to be crushed and processed, the preparation process is simple, and the cost is low; it can provide a new way for the harmless treatment and resource utilization of cassava residue, and at the same time alleviate the excessive exploitation of non-renewable natural resources such as peat, which is conducive to protecting the ecological environment.

The present invention provides a nano-particle comprising a shell and a polar core, their preparation, and their applications in ER fluids, polymeric product, rubber composition, tire product, hard disk drive gasket, matrix composition, and engine mount etc. The shell comprises a polymer formed from formula (I) monomers and the core comprises a polymer formed from formula (II) monomers, in which R₁ and R₂ are hydrogen; R₃, R₄, R₅, R₆, and up to three of R₇, R₈, R₉, and R₁₀ are each independently selected from the group consisting of hydrogen, methyl, ethyl, propyl, and isopropyl; and at least one of R₇, R₈, R₉, and R₁₀ is a polar group that is more polar than any one of R₁, R₂, R₃, R₄, R₅, and R₆ groups.

The invention provides methods and devices for the capture and removal of target biomolecules from a patient's body fluid, particularly blood or a blood component, using a partial imprint material. The partial imprint material is composed of a matrix composition having partial imprint cavities that correspond to a segment of a target biomolecule but which are capable of removing the entire target biomolecule from the body fluid. The method can be implemented by removing a volume of a patient's body fluid, e.g., blood, bringing the body fluid or a component thereof into contact with the partial imprint material under conditions effective to capture the target biomolecule, and returning the body fluid to the patient. A modified dialysis or apheresis device can be used in which the body fluid is removed, continuously passed through a circuit containing the partial imprint material, and re-introduced into the patient's body following treatment.

A neutron detector composed of a matrix of scintillating particles imbedded in a lithiated glass is disclosed. The neutron detector detects the neutrons by absorbing the neutron in the lithium-6 isotope which has been enriched from the natural isotopic ratio to a commercial ninety five percent. The utility of the detector is optimized by suitably selecting scintillating particle sizes in the range of the alpha and the triton. Nominal particle sizes are in the range of five to twenty five microns depending upon the specific scintillating particle selected.

The invention discloses a composite soldering material for soldering a titanium alloy and a ceramic or a ceramic matrix composition material and a method for soldering by using the same, and solves the problems that a welding joint obtained by soldering the titanium alloy and the ceramic or the ceramic matrix composition material through the conventional soldering material is easy to crack and has low strength, and the introduction of a ceramic phase in a method of introducing the ceramic phase into the soldering material causes reduction of wettability of a connecting layer for a base metal. The composite soldering material consists of Cu, Ni and a reinforced phase, wherein the reinforced phase is TiB2 powder or SiC powder. The method comprises the following steps of: performing ball milling on the Cu, Ni and TiB2 or SiC powder, uniformly mixing, and coating to-be-welded surfaces of the titanium alloy and the ceramic to obtain to-be-welded parts; and putting the to-be-welded parts into a vacuum brazing furnace for vacuum brazing treatment. In the soldering process, the composite soldering material has good wettability for the ceramic and ceramic materials, and the obtained welding joint has no crack, the shear strength between 16 and 45MPa, and good mechanical properties.