170 results about "Implantation Site" patented technology

A pharmaceutical composition according to an aspect can be applied to the prevention, treatment or the like of endometrial damage, Asherman's syndrome, or complications thereof by: reducing the level of collagen accumulation in the endometrium; increasing the expression level of VEGF; increasing the expression level of Ki67; increasing the expression level of Itgb3; increasing the expression level of Spp1; increasing the number of implantation sites; decreasing the expression levels of fibrosis-related factors; decreasing the expression levels of metabolism-related factors; increasing ATP production; and regulating the expression levels of mitochondrial function-related factors.

The invention relates to the field of biomedicine, and discloses a spine implant design method and system using the self-sensing characteristic of a piezoelectric material, and the method comprises the steps: collecting spine three-dimensional image data and clinical diagnosis information, recognizing the spine lesion characteristic and the spine implantation part of a target patient, and determining the basic structure size of a spine implant; setting a perception sensitivity level of the spine implant in the body of the target patient to generate perception performance judgment conditions of the spine implant; analyzing the biocompatibility requirement of the spine implantation part, and identifying the biological adaptation mode of the piezoelectric material in the body of the target patient; and embedding a piezoelectric signal processing module in the spine implant, and executing parameter optimization processing of the spine implant in combination with the biological adaptation mode and the perception performance judgment condition to obtain a target spine implant. According to the invention, the working state of the postoperative implant and the rehabilitation progress of the spine can be accurately evaluated.

The application provides application of SEBS in implanting a biological electrode base. The biological electrode based on the SEBS base can be implanted in biological tissues, and is used for continuously or discontinuously analyzing physiological parameters of the biological body. Compared with other flexible bases, the SEBS base has the characteristics of being thinner and more flexible, can reduce the interference of body movement on the electrical signal, reduce the volume range of the implanted tissue and reduce the inflammatory reaction, thereby improving the measurement accuracy and long-term stability, is expected to meet more implantation site requirements when used for implanting a sensor, and has a good application prospect.

A system for delivering a collapsible and re-expandable prosthetic heart valve into a patient includes a valve support structure around which the valve is disposed in a collapsed condition. A sheath structure surrounds the collapsed valve, but can be moved relative to the valve to uncover it for expansion at the desired implant site in the patient. The sheath structure may be variously mounted and moved to deploy the valve in various ways. For example, the sheath structure may include multiple parts, each of which can be moved separately to separately deploy various parts of the valve. The apparatus may have other aspects, such as the ability to reverse deployment of the valve, the ability to pass other instrumentation through the valve delivery apparatus, the ability to be smoothly withdrawn from the patient after deployment of the valve, etc.

The invention discloses an orthodontic micro-implant nail implanting method, device and system and a storage medium. The method comprises the following steps: S1, acquiring CBCT three-dimensional data; and S2, analyzing CBCT three-dimensional data through AI artificial intelligence to calculate an optimal implantation site and an implantation direction path, and designing an implantation guide plate mounted on the surface of the dental crown. By the adoption of the technical scheme, the success rate of implanting the micro-implant nail is increased, relevant soft and hard tissue indexes in the CBCT three-dimensional image are integrated, and the burden and judgment errors of an orthodontic doctor in measurement and positioning are reduced.

The present disclosure relates to a magnetoelectric-based wireless bioimplant (MEWB) that can transmit biological activities sensed via a pair of electrodes to an external transceiver by leveraging magnetoelectric (ME) transducer that is coupled to the implant. The MEWB is also capable of wirelessly receiving power and data via the ME transducer from external transceiver when brought closer to the implanted site (e.g., at few centimeters), thus structuring a batteryless and a leadless bioimplant. MEWB may be implanted epidermally through a pair of electrodes on an organ to capture accurate biological activities. The external transceiver may include a transmitter coil for generating an alternating magnetic field and to transmit downlink data and a receiver coil to sense a backscattered field generated by MEWB and to demodulate uplink data. The overall structure of the disclosed implant is adopted enabling compactness, miniaturization (e.g., <3cm in length and <4mm in diameter) and endovascular delivery.

A method of treating a patient in need of an orthopedic implant is described. The method includes obtaining the T-score or bone density of the patient's native bone at a site of implantation, said T-score or bone density being determined by a DEXA scan or other means of determining a T-score or bone density. The method further includes selecting an orthopedic implant that has about the same density as the native bone at the site of implantation, and implanting the orthopedic implant at the site of implantation.

An occlusion device or plug having a proximal plug section and a distal plug section. The plug sections may each be shifted between an unexpanded configuration and an expanded configuration at the deployment site to occlude the deployment site. A tubular member such as a silicone tube may be used to form an occlusion device or plug shiftable or expandable into a desired configuration. An intermediate section between a proximal plug section and a distal plug section may be configured to be manipulated at least to shift at least one of the plug sections from an expanded configuration to an unexpanded configuration. A pair of stents may be coupled together via an intermediate section in such manner such that manipulation of the intermediate section causes at least one of the stents to shift from an expanded configuration to an unexpanded configuration.

In some embodiments, a bone implant for percutaneous use is provided. The bone implant comprises a head, a body adjacent to the head and a tip opposite the head. At least the head, body or tip is configured to contact bone. An expandable member contacts at least one of the head, tip or body and is movable from an unexpanded configuration to an expanded configuration when deployed at a bone implant site. In some embodiments, a system for percutaneous bone harvesting is provided.

A method of implanting a prosthetic heart valve can include advancing a delivery apparatus with a prosthetic heart valve mounted on a distal end portion of the delivery apparatus in a radially compressed configuration distally until the prosthetic heart valve is disposed at a selected implantation site. The method can further include radially expanding the prosthetic heart valve by applying a proximally directed force to at least one actuation member of the delivery apparatus that is coupled to the prosthetic heart valve. When the proximally directed force applied to the at least one actuation member exceeds a predetermined force during the radially expanding the prosthetic heart valve, the method can include arresting movement of the at least one actuation member and stopping radially expanding the prosthetic heart valve.

A bone foundation guide system has a bone foundation guide including a body that is contoured to reversibly affix to a bone segment of a dental implant surgical site, the body being further contoured accept and to guide the cutting of a portion of the bone segment from a dental implant surgical site and as well as to alternatively support a dental implant surgical guide; the dental implant surgical guide; and a bone foundation guide prosthesis as an alternative to the dental implant surgical guide. The bone foundation guide prosthesis combines with the body to accommodate the bone segment portion as placed through the body prior to the bone segment portion being removed from the dental implant site through the use of the body.

This invention discloses a composite material, its preparation method, and an implant, belonging to the field of medical materials technology. The composite material is obtained by combining a piezoelectric material and a metal ion-releasing material; the metal ion-releasing material is selected from one or more of magnesium-based biodegradable alloys, iron and iron-based biodegradable alloys, and zinc and zinc-based biodegradable alloys. The composite material can adaptively generate microcurrents of varying magnitudes at different stages of patient recovery through the piezoelectric response of the piezoelectric material. These microcurrents promote intelligent degradation of the metal ion-releasing material that matches the patient's own recovery process. The resulting metal ions and the microcurrents jointly promote healing at the implantation site, which is of great significance for the development and application of implant materials.

An introductory lead system can include a first implantable lead having a first electrode and a second implantable lead having a second electrode guided to an implant site by the first implantable lead. The second electrode can be implanted in a patient's heart at the same implant site as the first electrode or at a second implant site. The introductory lead system can be delivered to one or more implant sites using various methods, including at the Koch triangle for ventricular free wall to atrium (VfA) therapy, at the right ventricular septal wall for dual bundle branch pacing, or in the coronary vasculature for left-sided sensing and pacing.

The present invention discloses a stent graft, comprising a plurality of coils, wherein the plurality of coils are arranged in an axial direction; a membrane, wherein the membrane is arranged on the plurality of coils, wherein the membrane and the plurality of coils form a hollow tubular structure with openings at both ends, wherein the membrane is woven from wires; and a restraining member, wherein the restraining member is provided at the edge of at least one open end of the hollow tubular structure, wherein the end of the membrane is covered by the restraining member, thereby restraining the wires at the end of the membrane. According to the stent graft of the present application, by providing a restraining member at the opening of at least one end of the hollow tube formed by the membrane and the plurality of coils, the end of the membrane is covered by the restraining member, thereby restraining the wires at the end of the membrane, thereby effectively preventing the trimmed wires at the edge of the membrane from extending through the pores of the restraining member, preventing the burr fibers at the edge of the membrane from irritating and damaging the blood vessels at the implantation site, and reducing unnecessary damage to the patient.

A method of percutaneously implanting a neurostimulator implant in tissue of a patient, the neurostimulator implant having a wireless power receiver and an elongate electrode lead, includes percutaneously implanting the neurostimulator implant such that the wireless power receiver is oriented towards the skin surface of the patient at the implantation site.

A holder for an annuloplasty ring that detaches with one cut. The annuloplasty ring mounts around a periphery of the holder without the use of connecting sutures. The holder has a proximal plate defining a lip on one side of the ring, and a distal retainer that defines a second lip on the other side, the two lips retaining the ring around the holder periphery. The distal retainer is formed by two hinged wings. A truss suture maintains the holder in a trussed configuration while the annuloplasty ring is delivered and secured to the implantation site. Once the ring is secured at the annulus, the truss suture is severed with one cut, enabling the hinged wings to pivot and the holder to be pulled free of the ring.

The present disclosure describes a holder for an annuloplasty ring that is detached using a single cut. The annuloplasty ring is mounted around the periphery of the holder without the use of connecting sutures. The holder has a proximal plate that defines a lip on one side of the ring and a distal retainer that defines a second lip on the other side that retains the ring around the holder perimeter. The distal retainer is formed of two hinged wings. When the annuloplasty ring is delivered and secured to an implantation site, a truss suture maintains the holder in a trussed configuration. Once the ring is secured at the annulus, the truss suture is severed with a single cut, enabling the hinged wings to pivot and enabling the holder to be pulled away from the ring.

The name of the invention is compositions and methods for enhancing cancer radiotherapy. A nutritional supplement comprising fish oil and selenium has been determined to enhance radiotherapy of tumors in a synergistic manner. The co-therapy of such supplements and radiotherapy results in a significantly improved reduction in tumor volume in animal models and reduces the common side effects, such as weight loss, inflammation and gastrointestinal tract damage, relative to radiotherapy alone. It has also been found that this co-therapy can reduce the incidence of metastasis from a primary implant site and modulate the expression of genes associated with apoptosis in tumor cells. Formulations of such supplements with good tolerance and palatability are also provided.

Valve holders and introducers for delivering a prosthetic heart valve to an implant site are in various embodiments configured to facilitate insertion of prosthetic valves through small incisions or access sites on a patient's body. The valve holders can also be configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. A valve holder according to embodiments of the invention includes features that reduce or eliminate mistakes during implantation of the prosthetic valves, such as a removable activator dial and a removable handle that prevent implantation of the valve prior to proper deployment or adjustment of the holder. An introducer is provided which can facilitate passing of a prosthetic valve between adjacent ribs of a patient. Valve holders and introducers according to the various embodiments can be used in minimally invasive procedures, such as thoracotomy procedures.

Disclosed herein are methods of manufacturing injectable microgel scaffolds, including methods of producing, purifying and concentrating microgel particles therein. The microgel scaffolds of the present disclosure are useful for a wide range of applications, such as stabilizing an implanted medical device in an implant site in a subject. The microgel scaffolds are fluidic during application and annealed or crosslinked after application to the implant site in the subject. The microgel scaffolds may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.

Heart valve prosthesis delivery devices and methods. The devices include a delivery catheter and stabilization catheter. The stabilization catheter has expandable anchoring segments to anchor the device at a cardiac site superior to the implantation site of the heart valve prosthesis. The stabilization catheter also has a tubular assembly that includes an outer tubular member and an inner tubular member translationally displaceable within the outer tubular member. The outer tubular member defines a longitudinally extending slit and the inner tubular member defines an aperture positionable within the longitudinally extending slot. The device includes a snare and the location of the distal end of the snare adjacent to the distal portion of the delivery catheter is adjustable via translational displacement of the inner tubular member relative to the outer tubular member.

A stent graft for treating an arterial aneurysm includes loops fixed to struts of stents, wherein the struts define distal and proximal apices. The ends of a ligature can be linked by a wire in a stent graft delivery system that threads anchor loops longitudinally spanning ends of the ligature to maintain the stent in a radially constricted position during delivery to the aneurysm. A delivery system and method for implanting a stent graft prosthesis includes and employs a torque component at a distal end of the stent graft prosthesis, whereby following advancement of the stent graft to a surgical site in a constrained or partially constrained configuration, torque is applied to the torque component to rotationally align the stent graft about a longitudinal axis of the stent graft, followed by deployment of the stent graft in correct rotational alignment. A delivery system and method of its use includes an apex capture assembly, a leg clasp, and a leg stop for capturing a stent graft during orientation and stabilization at an implantation site of a surgical site.

Nonwoven resorbable pouches that at least partially enclose implantable medical devices and improved methods for producing the implantable medical device pouches are described. The nonwoven pouches may comprise one or more drugs. Implantable medical devices that are placed in the pouches prior to implantation are prevented from migrating from the site of implantation by tissue ingrowth into the pouch. Antibiotics may be incorporated into the pouches to prevent post-operative infections. The pouches may be formed in fewer steps than conventional pouches, and without polymer coatings. Nonwoven pouches can be formed in one step by dry spinning instead of using multiple processing steps. In embodiments, the nonwoven pouches are smoother on the inside than the outside to tightly fit the implantable medical devices internally while encouraging external tissue ingrowth. In embodiments, the nonwoven pouches eliminate the use of knitted or woven multifilament fibers that can trap bacteria and result in post-operative infection.

A medical device includes a housing that defines both a lead bore and a compartment. A separate housing can be inserted into the compartment, where the separate housing can include the circuitry of the medical device, such as circuitry to provide stimulation and / or sensing. Electrical conductors interconnect terminals of the separate housing with electrical connectors within the lead bore. The two housings can have different shapes and can be constructed of different materials. The shape and size of the housing that defines the lead bore and the compartment can be sized for a particular implant site, while providing a compartment sized for the separate housing.

This invention discloses a method for preparing a strontium titanate modified layer on the surface of zirconia based on an impregnation-heat treatment method, comprising: (1) mixing titanium sulfate, urea and water to obtain a precursor liquid A, placing zirconia ceramic in the precursor liquid A, heating to boiling and maintaining for a period of time, then removing the zirconia ceramic, and after heat treatment A, preparing a titanium dioxide film on the surface of zirconia; (2) mixing H2O2 aqueous solution, ammonia and deionized water, adding metatitanic acid and stirring to dissolve, obtaining a precursor liquid B, placing the zirconia with the titanium dioxide film in the precursor liquid B, and allowing it to stand and react for a period of time at room temperature, depositing zirconia modified with a titanium dioxide precursor layer; (3) dissolving strontium acetate, or a mixed salt composed of calcium acetate and / or magnesium acetate and strontium acetate in deionized water to obtain an impregnation treatment solution, placing the zirconia modified with the titanium dioxide precursor layer in the impregnation treatment solution, allowing it to stand and react for a period of time, and then removing it, and after heat treatment B, preparing a strontium titanate modified layer on the surface of zirconia. The strontium titanate layer prepared on the surface of zirconia ceramic in this invention is tightly attached to the zirconia substrate and has high hydrophilicity, which is conducive to the adhesion of proteins and cells in the human body. At the same time, it can release active factors such as strontium ions for a long time to promote bone formation and bone regeneration at the implantation site, ultimately enhancing the osseointegration capacity of the zirconia implant.

Disclosed herein is a deployment instrument including: a shaft (2) having a longitudinal axis (X1); a handle (3) at a first end of the shaft (2); and a carrier portion (4) at a second end of the shaft (2). The carrier portion (4) is configured for holding an expandable heart valve prosthesis in a radially collapsed condition for delivery to the implantation site. The carrier portion (4) includes a hub (5) fixed to the handle (3) via the shaft (2), a first deployment element (6) and a second deployment element (7), each of said first deployment element (6) and second deployment element (7) configured to hold a corresponding portion of an expandable heart valve N prosthesis in a radially collapsed condition. A drive member (8) is provided which is configured to operate the first deployment element (6) and the second deployment element (7) in first and second opposite directions. The instrument is also provided with a mechanism to allow a displacement of the second deployment element in the second direction independently of the drive member (11).

This invention relates to the field of teaching model equipment, specifically a support device for rhinoplasty surgery. It includes a fixed frame with arc-shaped sides and a straight middle section. An adjustment strap is connected to the rear of the fixed frame. An installation groove is formed on the upper front side of the fixed frame, inside which a control sleeve is placed. The support body is housed within the control sleeve. The support body is cylindrical, and a push rod is installed inside. The outer side of the push rod fits against the inner side of the support body, with one end extending out of the support body. When the fixed frame is installed on the patient's face, the prosthesis can be inserted into the opening of the support body. The support body then slides within the control sleeve. A ball joint rotates within a ball joint groove, controlling the up, down, left, and right swing angles of the support body to achieve precise alignment with the opening. Finally, pushing the push rod allows the prosthesis to be precisely inserted into the desired implantation site.

This invention provides methods for optimal implantation of a solid substrate for promoting cell or tissue growth or restored function in an osteochondral, bone or cartilage tissue in a subject in need thereof. The methods include selecting and preparing a solid substrate for promoting cell or tissue growth or restored function for implantation, which solid substrate has a length and width or that promotes a tight fit within the boundaries of the implantation site and is further characterized by a height sufficient such that when a first terminus of said solid substrate is implanted within a bone in a site for implantation, a second terminus of said solid substrate is at a height at least 2 mm less than an articular cartilage layer surface or is proximal to a tide mark region in said implantation site and optionally applying a biocompatible polymer layer to an apical surface of said implant, which layer does not exceed the articular cartilage layer surface in height. Tools for implementation of optimal positioning are described including a unique tool (5-120) for trimming cartilage at the implantation site.

An implantable hemodynamic monitoring system comprising a sensor comprising a substrate and a fiber optic connected to the substrate, the sensor configured to be implanted within a blood vessel, wherein the fiber optic comprises one or more reflective gratings, and an interrogator positioned on a skin surface at a position underlying the implantation site of the sensor enabling wireless communication by passing light through the skin to the sensor. Also described herein is a method of measuring blood pressure.

The present application relates to an occlusion device comprising a fixing portion and a sealing portion. The fixing portion comprises a plurality of support bodies. The sealing portion comprises a main body portion and a wing portion arranged around the periphery of the main body portion. The wing portion comprises a root portion connected to the main body portion and a free end extending outward and distally from the root portion. During implantation, the wing portion can enlarge the contact area between the main body portion and an implantation site, thereby enhancing the supporting effect of the main body portion. Simultaneously, the main body portion is compressed to a smaller volume due to the presence of the wing portion, consequently generating greater radial supporting force.