163 results about "Lactide" patented technology

The invention provides a degradable fiber temporary plugging agent and a preparation method thereof, and belongs to the technical field of oil-gas field development. The temporary plugging agent is composed of polylactic acid-polyurethane block copolymer fibers, and the preparation method of the temporary plugging agent comprises the steps that S1, lactide and an initiator containing dihydroxyl are subjected to ring opening polymerization under the action of a first catalyst, and a hydroxyl-terminated prepolymer is formed; s2, reacting the prepolymer with diisocyanate under the action of a second catalyst to synthesize a polylactic acid-polyurethane block copolymer; s3, preparing fibers through a melt spinning or electrostatic spinning process; the degradation rate and the mechanical property of the fiber can be regulated and controlled by regulating and controlling the initiator type, the diisocyanate type, the isocyanato index R value and the catalyst dosage, so that the fiber is suitable for the wide-temperature-range reservoir conditions of 45-120 DEG C, and the technical problems of contradiction between the strength and the degradability, narrow temperature adaptability, secondary damage to the reservoir and the like of a traditional temporary plugging agent are effectively solved.

The invention relates to a separation qualitative and quantitative detection method for L-lactide, D-lactide and Meso-lactide, and belongs to the field of lactide optical purity detection.The separation qualitative and quantitative detection method comprises the following steps that firstly, various lactide standard curves of different configurations are established respectively, the concentration range of the standard curves is 10-1000 mg / L, and the concentration range of the standard curves is 10-1000 mg / L; the plurality of lactides with different configurations comprise one or more of L-lactide, D-lactide and Meso-lactide; and the lactide with different configurations comprises one or more of the L-lactide, the D-lactide and the Meso-lactide. 2, detecting by using a gas chromatograph-mass spectrometer, and quantitatively calculating a lactide substance to be detected, wherein the concentration range of the lactide substance to be detected is 200-1000mg / L; according to the invention, separation and quantitative detection of three lactide optical isomers are realized by using an analysis method; the influence of impurities in the to-be-detected substance of lactide on the accuracy of the quantitative result of lactide is reduced; qualitative and semi-quantitative information of the impurities in the to-be-detected substance is provided.

The invention discloses a degradable antibacterial anti-inflammatory polyurethane sponge and a preparation method thereof. The preparation method of the polyurethane sponge comprises the following steps: preparing caprolactone / lactide copolymer diol by taking epsilon-caprolactone, DL-lactide and 1, 4-butanediol as raw materials under the action of an organic zinc catalyst ZCAT-T50, and then preparing the polyurethane sponge by taking polyethylene glycol and the caprolactone / lactide copolymer diol as raw materials and 4, 4 '-dicyclohexylmethane diisocyanate as a cross-linking agent under the action of the organic zinc catalyst ZCAT-T50. And finally, sequentially adding an organic zinc catalyst ZCAT-T50, a chitosan oligosaccharide emulsion and a budesonide ethanol solution into the polyurethane prepolymer, and carrying out chain extension, foaming and curing, so as to prepare the budesonide-modified polyurethane composite material. The polyurethane sponge prepared by the invention has excellent mechanical properties, degradability and antibacterial and anti-inflammatory properties, is suitable for making medical hemostatic sponge, and has remarkable economic value and social benefit.

The invention discloses a lumepirone long-acting microsphere sustained-release preparation without a release stagnation period in an early stage, which comprises a lumepirone active ingredient and a medicinal polymer auxiliary material in a mass ratio of (1: 4)-(1: 1), the medicinal polymer auxiliary material is at least one of glycolide-lactide copolymers with the weight-average molecular weight of 5000-150000 Da, and the molar ratio of lactic acid units to glycolic acid units of the glycolide-lactide copolymers is (50: 50)-(95: 5). The lumepirone long-acting microsphere sustained-release preparation without a release arrest phase in the early stage is obtained by specially limiting drying conditions in liquid and medicinal polymer auxiliary materials, the release of the lumepirone long-acting microsphere sustained-release preparation can be maintained for 2 weeks to 1 month without oral administration of the long-acting sustained-release microspheres of lumepirone capsules, the safety and effectiveness of the medicine are met, and the sustained-release preparation is suitable for clinical application. Meanwhile, the problems of early-stage long-time stagnant release and early-stage burst release of the long-acting microsphere preparation can be solved, the compliance can be effectively improved, convenience is provided for patients to the maximum extent, and the economic cost is reduced.

The invention belongs to the technical field of algal polysaccharide extraction, and discloses a modification extraction method of algal asparagus polysaccharide and a method for preparing a lutein coating by using the algal asparagus polysaccharide. The modified extraction method comprises the following steps: extracting gracilaria lemaneiformis powder with a weak base solution, enabling lactide and polysaccharide to be subjected to grafting reaction through a redox initiation system under the assistance of ultrasonic waves, and then separating out a first polysaccharide component with high emulsibility and a second polysaccharide component with high gel property through graded alcohol precipitation. The two obtained functional components are used for coating xanthophyll, specifically, the first polysaccharide component emulsifies a xanthophyll oil phase to form a pre-emulsion, the second polysaccharide component is compounded with gelatin, a composite coacervate is formed on an oil drop interface by adjusting the pH value, and finally drying and curing are conducted. According to the method, two modified polysaccharides with definite functions can be synchronously obtained, the prepared xanthophyll coating is high in encapsulation efficiency, good in storage and processing stability and excellent in water dispersibility, and the problems that xanthophyll is unstable and difficult to apply are effectively solved.

This invention discloses a lactide-Nisin solid dispersion and its preparation method. The method includes preparing a mixture of lactide and a hydrophobic solvent; dispersing Nisin in the mixture obtained in the previous step to obtain a multi-component mixture; and cold-treating the multi-component mixture to obtain a solid mixture containing lactide and Nisin. This invention fully utilizes the binding properties of lactide and Nisin, effectively enhancing the stability of Nisin in complex environments, further expanding the application potential of the prepared antibacterial agent, and providing a new approach for developing multifunctional green food preservatives.

The application provides a degradable material, which comprises poly(lactic acid-amino acid) / polycaprolactone microspheres; the poly(lactic acid-amino acid) / polycaprolactone microspheres are prepared by blending poly(lactic acid-amino acid) and polycaprolactone; the proportion of poly(lactic acid-amino acid) and polycaprolactone in the poly(lactic acid-amino acid) / polycaprolactone microspheres is (1-10):(1-10); the polymerization monomers of the poly(lactic acid-amino acid) comprise lactide and amino acid, and the proportion of the lactide and the amino acid is (2-10):1; the median particle size D50 of the poly(lactic acid-amino acid) / polycaprolactone microspheres is 30-300 mu m, and the particle size distribution is less than 1.0. The poly(lactic acid-amino acid) / polycaprolactone microspheres provided by the application solve the problems of slow degradation rate, poor hydrophilicity and mechanical property of the existing degradable material by introducing the hydrolysis bond group in the amino acid, and have good degradation performance and stability.

The invention discloses a composite material for oral bone repair and a preparation method and application thereof, and the composite material comprises the following components in parts by mass: 40-60 parts of a polymer matrix and 40-60 parts of a reinforcing filler dispersed in the polymer matrix; wherein the polymer matrix comprises a multi-arm polycaprolactone-lactide copolymer, and the reinforcing filler comprises hydroxyapatite of which the surface is modified with hydrophobic molecules. According to the invention, the composite material for repairing the oral cavity bone, which is moldable and anti-collapsing and has a degradation rate matched with bone growth, and the preparation method and the application of the composite material can be provided.

The present invention provides a preparation method for lactide, and direct lactide and depolymerized lactide. The preparation method comprises: carrying out a prepolymerization reaction on lactic acid to obtain a prepolymerized product; demonomerizing the prepolymerized product; the components separated from the prepolymerized product after demonomerization including direct lactide; and carrying out a depolymerization reaction on the remaining prepolymerized product after demonomerization to obtain depolymerized lactide. The preparation method of the present invention involves a simple process, and lactide having high optical purity can be obtained without melt crystallization.

The invention discloses a skin implant, the skin implant is a freeze-drying agent, the freeze-drying agent is prepared from the following components in parts by weight: 2-15 parts of a PEG-PLA copolymer and 0.05-4.0 parts of hyaluronate, the PEG-PLA copolymer is prepared from a single-terminal hydroxyl polyethylene glycol compound and lactide through a polymerization reaction, and the hyaluronate is prepared from the following components in parts by weight: 1-10 parts of a cross-linking agent, 1-10 parts of a cross-linking agent, 1-10 parts of a cross-linking agent and 1-10 parts of a cross-linking agent. The mass ratio of the single-end hydroxyl polyethylene glycol to the lactide is (2.0-8.5): 1, and the molecular weight of the hyaluronate is 10-100 WDa. The skin implant provided by the invention has an excellent redissolution speed and can be quickly redissolved within 10 minutes, and the quick redissolution characteristic of the freeze-drying agent greatly facilitates clinical operation and shortens the preoperative preparation time.

This invention discloses a biomass hot melt adhesive and its preparation method, belonging to the field of environmentally friendly adhesive technology. Addressing the industry pain points of existing biomass hot melt adhesives, such as difficulties in melt processing and the inability to simultaneously achieve both bonding performance and environmental friendliness, this invention uses a modified lignin graft copolymer prepared by a ring-opening grafting reaction of lignin sulfonate with L-lactide and ε-caprolactone as the matrix, compounded with nano-cellulose whiskers, cashew phenol-based plasticizers, composite crosslinking agents, and bio-based antioxidants to construct a fully biomass formulation system. The product is obtained through a solvent-free melt reaction blending process. The product of this invention is completely biodegradable, possesses excellent hot melt processability, bonding strength, water resistance, and storage stability, and the preparation process is green and environmentally friendly, suitable for large-scale industrial production, and can replace traditional petroleum-based hot melt adhesives.

The invention belongs to the field of high polymer materials, and discloses a method for efficiently catalytically synthesizing polylactic acid, which is characterized by comprising the following steps: adding lactide, a tin catalyst and an initiator into a reactor, quickly heating to 180 + / -20 DEG C under the protective atmosphere and stirring, and carrying out polymerization reaction for more than 10 minutes to obtain high-molecular-weight polylactic acid; the initiator is hydroxy acid and is monobasic acid. The lactide polymerization rate is greatly improved, the polymerization reaction can be completed within more than ten minutes, the lactide conversion rate is 94% or above, the molecular weight is 2.17 * 10 < 5 > Da or above, and the lactide reaches the level of commercial polylactic acid. Compared with a tin catalyst and a tin catalyst / alcohol composite catalytic system, the catalytic system has the advantages that the polymerization rate at the initial reaction stage is increased by 20-30%, and the reaction time is shortened by more than 80%. The catalytic system is applied to a process for synthesizing polylactic acid through reactive extrusion, and the production efficiency of an extruder can be remarkably improved.

The application discloses a kind of high uniformity medical grade absorbable polyester, preparation method and production system, production system includes kettle type closed stirrer, auxiliary tank, three-way valve and closed kettle type reactor;Three-way valve is communicated with kettle type closed stirrer by melt metering pump;It is communicated with auxiliary tank by micro-injection pump;It is communicated with closed kettle type reactor by static mixer;The side inside of three-way valve and micro-injection pump communication side is designed funnel shape, including funnel neck and funnel mouth, the side surface and bottom surface of funnel neck are equipped with uniform small hole.The application discloses a kind of system specially used for preparing high uniformity medical grade absorbable polyester and the preparation method matched therewith, by using special production system again cooperation specific process parameter can successfully prepare with medical grade absorbable polyester, especially suitable for the preparation of poly-l-lactide and polyglycolide with higher viscosity, more difficult to produce, the product obtained has high uniformity, high molecular weight and low monomer residue.

Provided is a method for preparing lactide by one-step reaction of lactic acid, which comprises mixing lactic acid raw material with a solvent and contacting with a catalyst, wherein the solvent comprises solvent I and solvent II, the solvent I is at least one selected from polar solvents such as benzophenone, dihydrolevoglucosenone, N-methylpyrrolidone, trichloropropane and sulfolane, the solvent II is C4-C12 alkane, substituted alkane, aromatic hydrocarbon or substituted aromatic hydrocarbon, the solubility of the solvent II for lactic acid at normal temperature is not more than 1 g lactic acid / 100 g solvent; and the reaction temperature and pressure are such that the solvent I does not boil in the reaction system. The mixed solvent is used as the liquid environment for preparing lactide by one-step reaction of lactic acid, the mixed solvent can be completely miscible with lactic acid in the reaction raw material, on the one hand, it can increase the contact between lactic acid and the solid catalyst, make the reaction more complete, reduce the generation of by-product poly lactic acid, and increase the selectivity of lactide; on the other hand, since the poly lactic acid can also be dissolved in the selected solvent, the adhesion of the poly lactic acid on the catalyst can be reduced, the influence of catalyst deactivation caused by carbon deposition can be reduced, and the service life of the catalyst can be improved.

According to the construction process, a hopper feeding device, a transmission system, a heating extrusion device, a cooling shaping device, a cutting device, a thread rolling device, a traction device, a grinding device and a sterilization device are arranged. The acupuncture needle prepared from the poly (lactic-co-glycolic acid) material has good non-toxic biodegradability, the acupuncture needle prepared from the poly (lactic-co-glycolic acid) material has good in-vivo biocompatibility, degradation products of lactic acid and glycolic acid can participate in metabolism of a human body, and finally carbon dioxide and water are formed and discharged out of the body. Meanwhile, the material is degraded by organisms and microorganisms in the natural world in the natural environment; by adding the traditional Chinese medicine pigment and adding a small amount of surfactant (phenol polyethylene glycol solvent or zinc naphthenate), the finished acupuncture needle has excellent weather resistance, light resistance, chemical corrosion resistance and ultraviolet resistance.

The invention belongs to the field of polymer synthesis, and discloses a bimetallic catalyst and a method for preparing lactone and lactide homopolymer or copolymer by using the bimetallic catalyst, which comprises the following steps: adding the bimetallic catalyst, lactone and / or lactide, selectively adding a chain transfer agent and selectively adding an organic solvent into a reactor, and stirring for a certain time at a certain reaction temperature to obtain the bimetallic catalyst. Stopping the reaction time; and adding a large amount of methanol or ethanol into the crude product, violently stirring to precipitate the polymer, and repeating the precipitation process to obtain the polyester. The bimetallic catalyst is designed and synthesized, and autopolymerization and copolymerization of lactide or lactone can be synergistically catalyzed by bimetallic. Compared with a single-metal catalyst, the activity is greatly improved; according to the invention, magnesium, zinc and calcium necessary for human bodies are used as catalyst centers, so that potential dangers caused by toxic catalysts are avoided.

The application provides a method for stereoselectively preparing racemic lactide from racemic lactic acid, and relates to the technical field of catalysts.The application provides application of a molecular sieve in catalysis of stereoselective preparation of racemic lactide from racemic lactic acid, and the molecular sieve is H-Beta molecular sieve or H-ZSM-5 molecular sieve.The application uses H-Beta or H-ZSM-5 molecular sieve in catalysis of stereoselective preparation of racemic lactide from racemic lactic acid, so that the selectivity of obtaining meso-lactide from racemic lactic acid is reduced, the selectivity of obtaining Rac a high proportion of racemic lactide from racemic lactic acid is increased D / L LD is increased, and the selectivity of obtaining Meso LD is further reduced, and the selectivity is increased.

The invention relates to a preparation method of cyclic poly (L-lactide), and belongs to the technical field of polymer preparation. According to the method, the cyclic poly (L-lactide) with high molecular weight is successfully prepared through a solvent-free ring-opening polymerization reaction at the reaction temperature of 110-180 DEG C by taking L-lactide as a polymeric monomer and taking a Sallaen type rare earth metal alkoxy complex as a catalyst. The method disclosed by the invention has the advantages that the catalytic efficiency is relatively high, the molecular weight of the obtained polymer is high, the polymer has a cyclic structure and the like, the method is green and solvent-free, and the product is a polymer only containing a cyclic topological structure.

The invention belongs to the technical field of medical treatment, and particularly relates to a preparation method of polylactide caprolactone PLCL used in the medical field, which comprises the following steps: S1, polymerization reaction: taking lactide and caprolactone as raw materials, adding the raw materials into a polymerization kettle, adding a reaction solution into the polymerization kettle, vacuumizing the polymerization kettle, heating and stirring under the heating and stirring action of the polymerization kettle, and reacting for 2-4 hours to obtain a reaction solution; forming a mixed solution; s2, polymer separation: adding a precipitant into the mixed solution to precipitate PLCL, separating PLCL from the reaction solution, and removing the reaction solution on the upper layer to obtain PLCL; s3, polymer drying: heating the PLCL to remove an organic solvent in the PLCL to obtain dried PLCL; and S4, polymer refining: carrying out fine grinding on the dried PLCL by using a grinding machine, screening the ground PLCL by using a fine screen, returning the PLCL which cannot be leaked from meshes of the fine screen to the grinding machine for continuous grinding, and obtaining the PLCL which is high in purity and conforms to the medical implantation level by using the PLCL which is leaked from the meshes of the fine screen.

The present disclosure provides a method for preventing blood coagulation, comprising administering an effective amount of ginsenoside compound K (CK) to a subject in need thereof. The present disclosure also provides a use of ginsenoside compound K (CK) in the manufacture of a medicament for preventing blood coagulation. The present disclosure further provides a drug-eluting percutaneous coronary intervention (PCI) device comprising a vascular implant, the surface of which is coated with a first layer comprising ginsenoside compound K (CK) and a first bioabsorbable polymer, the first bioabsorbable polymer comprising poly-L-lactic acid (PLLA) and poly(L-lactide-co-ε-caprolactone) (PLCL) in a mass ratio of 60%-80%:20%-40%.

This disclosure generally relates to the design of renewably sourced, readily degradable pressure-sensitive adhesives (PSAs) that exhibit tunable adhesion properties is beneficial to address sustainability concerns associated with traditional, fossil fuel-derived counterparts. More generally, aliphatic polyester triblock copolymers of poly(L-lactide)-block-poly(γ-methyl-ε-caprolactone)- blockpoly(L-lactide) (LML) and blends with renewable tackifier in PSA formulations are discussed. More particularly, effects of tackifier, composition, and processing history on microstructural, thermal, mechanical, and adhesive properties of the PSAs are disclosed. Specifically, LML-based PSAs are hydrolytically degradable into water soluble or dispersible compounds at 45°C under basic conditions within 30 days, offering a sustainable end-of-life scenario via its potential in composting makes for an ideal and sustainable alternative for commercial acrylic incumbents.

The present invention relates, inter alia, to a method for producing a microbubble, comprising (i) providing a polymerizable monomer and a non-polymerizable compound; and (ii) polymerizing the monomer in an aqueous solvent in the presence of the non-polymerizable compound to form a polymeric shell encapsulating an inner lumen; wherein the polymerizable monomer is selected from the group consisting of alkyl cyanoacrylates, alkyl acrylates, lactide, glycolide, and combinations thereof; and the non-polymerizable compound is capable of integrating into the polymeric shell as the polymerization proceeds so as to form a plurality of non-polymerized nanocavities.

The invention discloses a rapidly crystallized anti-aging polylactic acid composition as well as a preparation method and application thereof. The rapidly crystallized anti-aging polylactic acid composition comprises the following components: 70-95 parts of poly-L-lactic acid; 5 to 20 parts of multi-arm D-polylactic acid; 0.1 to 5 parts of acetylated cellulose nanocrystal; 0.05-1 part of a metal chelating agent; the multi-arm dextro polylactic acid is prepared by initiating ring opening polymerization of D-lactide by a polyol initiator, and the polyol initiator is selected from two or more of glycerol, 1, 1, 1-trimethylolpropane, pentaerythritol, erythritol, dipentaerythritol and sorbitol. The metal chelating agent is used for inhibiting hydrolysis of ester bonds, formation of stereocrystals is promoted under the action of the nucleating agent through the multi-arm right-handed polylactic acid of a branched structure, high transparency and heat resistance are obtained, and a blister product prepared from the composition has the advantages of being transparent, resistant to heat, rapid in demolding, stable in size and the like.

This invention relates to a method for preparing polylactic acid (PLA) by straw fermentation coupled with lactide ring-opening polymerization, belonging to the field of biomass resource utilization and bio-based polymer materials technology. To address the problems of high energy consumption and low sugar conversion rate in existing PLA preparation methods using crop straw, this invention provides a method for preparing PLA by straw fermentation coupled with lactide ring-opening polymerization. The method involves crushing the straw, pre-treating it with dilute acid coupled with steam explosion, washing and drying it, adding a complex cellulase and Lactobacillus pentosus LB-1 seed culture, and simultaneously saccharifying and fermenting under controlled temperature and pH to obtain a lactic acid fermentation broth. The fermentation broth undergoes multi-stage filtration, ion exchange, and concentration to obtain refined lactic acid, which is then prepolymerized, depolymerized, and distilled to obtain L-lactide. After purification, an initiator and antioxidant are added, and ring-opening polymerization, extraction, and drying are performed under nitrogen protection to obtain pure PLA. This invention features efficient and low-energy straw pretreatment, high sugar-acid conversion rate during fermentation, precise purification, stable polymerization, and low cost, making it a green and economical method using straw as raw material.

The application discloses a preparation method of antibacterial modified polylactic acid for packaging materials and belongs to the technical field of polylactic acid functional modification. The antibacterial and barrier type polylactic acid composite material is prepared through initiator ring-opening polymerization, antibacterial molecule grafting and montmorillonite blending. Ethanolamine and chloroacetyl chloride generate a chloro end group initiator, the initiator initiates the ring-opening polymerization of levorotatory lactide to form an end group active polylactic acid, the end group chlorine is subjected to nucleophilic substitution and covalently grafted with an antibacterial modifier, the polylactic acid is endowed with antibacterial properties, modified montmorillonite is subjected to organic intercalation and silane coupling and then is melt-blended with the modified polylactic acid with antibacterial properties, a layered barrier structure is formed and the interface combination is enhanced, so that the polylactic acid has high barrier property, high tensile strength, excellent bacteriostasis and good degradability.

This invention discloses a method for preparing heteroatom porous beta molecular sieves, comprising the following steps: (1) mixing deionized water, tetrahydrofuran, sodium oxide, sodium aluminate, and zwitterionic polymer PAAn- b - PILm is mixed and stirred evenly, and tetraethyl orthosilicate is added dropwise. The mixture is stirred at 35-45℃ for 8-16 hours; (2) it is transferred to a reaction vessel lined with polytetrafluoroethylene, crystallized at 75-85℃ for 36-60 hours, and then crystallized at 130-150℃ for 8-16 hours; then dried and calcined. At the same time, the present invention also discloses the Sn-beta molecular sieve catalyst for preparing lactide using the beta molecular sieve and its preparation method and its application in the preparation of lactide. The reaction conditions of the present invention are mild and suitable for high concentrations of lactic acid raw materials, which reduces the production cost and produces lactide with high purity, thus solving the problems existing in the two-step preparation of lactide.

The application relates to an electrostatic spinning anti-adhesion membrane and a preparation method and application thereof. The electrostatic spinning anti-adhesion membrane comprises an inner layer, an intermediate layer and an outer layer which are sequentially stacked; the inner layer comprises polyglycolide-lactide-polyethylene glycol, the intermediate layer comprises polyglycolide-lactide, and the outer layer comprises polylactic acid-caprolactone. The electrostatic spinning anti-adhesion membrane has a three-dimensional nanofiber network structure of a biomimetic extracellular matrix, excellent mechanical properties, body temperature response softening and gradient degradation characteristics, can balance the degradation speed and the mechanical properties, reduce the mechanical damage of the material to the surrounding tissues, and can effectively prevent postoperative tissue adhesion.

The application discloses a colored polylactic acid oligomer, a preparation method thereof and a polylactic acid colorant, and belongs to the technical field of polymer materials. The colored polylactic acid oligomer is prepared by directly initiating controllable ring-opening polymerization of lactide by using active amino groups in an organic dye, and is composed of linkage of the dye and homogenized polylactic acid molecular chains in a chemical structure, so that the colored polylactic acid oligomer has excellent compatibility and dispersibility in a polylactic acid base material, and thus the base material can still maintain original excellent performance when the colored polylactic acid oligomer is applied to the base material by blending. The homogenized polylactic acid molecular chains in the colored polylactic acid oligomer are linked to auxiliary groups of the dye instead of chromophores, so that the colored polylactic acid oligomer can present the same hue as the corresponding dye, and the color can be adjusted according to the red-yellow-blue (RYB) hue circle law to present diversification, and the original liquid coloring product can present the required color by simple blending.

The present application relates to the field of lactide preparation, in particular to a method and device for solidifying and collecting lactide from lactide-containing gas. The method comprises: lactide-containing gas and solvent-containing liquid are contacted in an ejector; wherein the solvent-containing liquid is used as working fluid to generate vacuum in the ejector, so that the lactide-containing gas is sucked into the ejector as injection fluid to contact the solvent, solidify the lactide and form mixed slurry. By using the method of the present application to solidify and collect lactide, the yield and lactide quality can be greatly improved, and the production cost can be reduced.

A process for treating a lactide feed to form a lactide stream having a high configuration purity and a high chemical purity, comprising the steps of:-subjecting a feed comprising L-lactide, meso-lactide, water, lactic acid and optionally other components to a first separation step, thereby obtaining a stream comprising lactic acid and water and one or more crude lactide streams; -subjecting the crude lactide stream comprising L-lactide and meso-lactide resulting from the first separation step to a first crystallization step, thereby obtaining a purified L-lactide stream and a residual stream comprising L-lactide and meso-lactide; -subjecting the residue stream comprising L-lactide and meso-lactide resulting from the first crystallization step to a second separation step, thereby obtaining at least a second L-lactide stream and a meso-lactide stream; -subjecting the meso-lactide stream resulting from the second separation step to a second crystallization step, thereby obtaining a purified meso-lactide stream and a further residue stream.