515 results about "Lactide" patented technology

The invention discloses an absorbable suture line for surgical suture and a preparation method thereof, and relates to the technical field of medical materials. The absorbable suture line for surgical suture is prepared from the following raw materials in parts by weight: 50 to 65 parts of polylactic acid, 15 to 20 parts of polyglycolic acid, 3 to 5 parts of sodium carboxymethyl cellulose, 3 to 8 parts of a toughening agent, 3 to 6 parts of an antibacterial agent, 0.3 to 0.8 part of a lubricating agent, 1 to 2 parts of sodium hyaluronate and 5 to 10 parts of polyvinyl alcohol. The toughening agent is obtained by reacting hydroxyethyl acrylate with ethylenediamine to generate a four-arm compound and then reacting with 6-caprolactone and DL-lactide. The absorbable suture line for surgical suture prepared by the invention has excellent tensile property and antibacterial property, and can meet the application requirements of clinical medical treatment.

The present invention discloses a class of nitrogen heterocycle-substituted hexa-dentate aminophenoxy rare earth complexes (I), a preparation method thereof, and an application thereof in the highly active catalytic ring-opening polymerization of lactones. The preparation method comprises the following steps: reacting a neutral ligand with a metal raw material compound in an organic medium, then adding an alcohol for reaction, and obtaining the target compound through filtration, concentration, and recrystallization. The nitrogen heterocycle-substituted hexa-dentate aminophenoxy rare earth complex of the present invention is a highly efficient catalyst for the ring-opening polymerization of lactones, and can be used for catalyzing the polymerization reaction of lactones such as lactide, and catalyzing the one-pot copolymerization of lactide and ε-caprolactone to obtain a multi-block copolymer. The nitrogen heterocycle-substituted hexa-dentate aminophenoxy rare earth complex of the present invention has good tolerance to impurities, has very high catalytic activity, and can obtain high molecular weight polyester materials. A has a structure shown in formula (II), (III), (IV) or (V); B has a structure shown in formula (VI) or (VII).

The invention discloses a degradable resin material, an optical property regulator, an optically-adjustable environment-friendly mulching film and a processing method of the optically-adjustable environment-friendly mulching film, and belongs to the field of degradable environment-friendly materials. The invention provides a degradable polyester resin material with a novel structure, namely polycaprolactone-co-lactide. The degradable polyester resin material is formed by performing ring-opening copolymerization on epsilon-caprolactone and lactide under the catalytic action of a symmetric binuclear Schiff base complex; the ratio of the average chain segment length of caprolactone to the average chain segment length of lactide in the resin material is (2-2.2): (2-2.2), which is close to that of an alternating copolymer. The compound can be used as an optical property regulator, and preparation of an environment-friendly mulching film with adjustable optical properties such as ultraviolet light absorbance, infrared light transmittance and haze can be realized under the condition that no dye or other coloring additives are used.

The invention discloses an anti-fibrosis drug coating degradable woven stent for treating urethrostenosis, the stent is a hollow cylinder formed by spirally weaving wires, the wires are made of biodegradable polymer materials, the surface of the stent is coated with a drug coating, anti-fibrosis drugs are selected as the drugs, and the anti-fibrosis drug coating is made of biodegradable polymer materials. The drug coating is prepared by using an ultrasonic atomization spraying method; the biodegradable polymer material comprises one or a compound of more than one of poly L-lactic acid, poly D, L-lactic acid, poly (L-lactic acid / D, L-lactic acid), poly (glycolide / lactide), poly (glycolide-lactide), poly (L-lactic acid / caprolactone), poly (glycolide / caprolactone), poly (D, L-lactic acid / caprolactone), polydioxanone and the like. The stent body is made into a self-expanding stent by adopting a weaving method; the biodegradable ureteral stent with the drug coating has good biocompatibility, degradability and mechanical property, and has a wide market application prospect.

The invention provides a poly-L-lactic acid microsphere. The poly-L-lactic acid microsphere is obtained by performing membrane emulsification on a poly-L-lactic acid-polyethylene glycol copolymer synthesized by taking lactide and polyethylene glycol as raw materials. According to the L-polylactic acid microspheres disclosed by the invention, the uniformity, the stability and the biocompatibility of the microspheres are improved, and meanwhile, the synthesis of skin collagen is promoted.

The present invention discloses a large-flux suspension crystallization purification device and its application in the purification of lactide, including a crystal washing tower and a crystal slurry melter, the crystal washing tower includes a separation section A, a refining section B and a washing section C, the crystal is crystallized and precipitated in the separation section and enters the refining section, a washing mother liquor outlet is provided above the separation section A, the washing mother liquor is discharged from the washing mother liquor outlet, the refining section B is provided with a stirring paddle, in the refining section B, the crystal grows and enters the washing section C, and is deposited in the washing section C to form a crystal accumulation bed, the lower end of the washing section is provided with a scraper, the bottom of the washing section is provided with a discharge port, the discharge port is connected to the crystal slurry melter, the lower end of the washing section is also provided with a liquid inlet and a distributor, the liquid inlet is connected to the crystal slurry melter. The present invention can be applied to the crystal washing process of purifying lactide by suspension crystallization, can significantly improve the lactide crystallization yield, and reduce the number of equipment and investment.

The present invention relates to a biodegradable polymer composition formed by waterborne radical emulsion polymerization of monomers selected from ethylenically unsaturated monomers characterized in that, the polymer composition is composed of at least two different populations of particles, said populations differing in average particle size value by at least a factor of 1.5, wherein (a) a population P1 is constituted by particles having an average particle size of greater than 250 nanometers, said particles being constituted of polymer chains predominantly built of ethylenically unsaturated monomers, further comprising 0.5 to 50% by C weight of oligomer lactide 2-hydroxyethyl, methacrylate terminated macromonomer, based on the total weight of the monomers, and (b) a population P2, distinctive of P1 by average particle size value, is constituted by particles having an average particle size of less than or equal to 250 nanometers, said particles being constituted of polymer chains predominantly built of ethylenically unsaturated monomers, further comprising 0.5 to 50% by weight of oligomer lactide 2-hydroxyethyl, methacrylate terminated macromonomer, based on the total weight of the monomers, wherein said two different populations jointly constitute at least 70% by weight, preferably 90% by weight, of the total polymeric content within said composition.

A collagen membrane with an effect of inducing ordered remodeling of tissues, a preparation method therefor, and use thereof, relating to the technical field of surgical supply materials. The preparation method for the collagen membrane comprises the following steps: subjecting a fiber membrane to a heat pressing treatment to obtain the collagen membrane with the effect of inducing ordered remodeling of tissues. The fiber membrane is formed by cross-stacked fibers with a diameter of 0.5-15 μm. The fibers comprise collagen and poly(L-lactide-co-caprolactone). The mass ratio of the collagen to the poly(L-lactide-co-caprolactone) is 1:(1.5-2.5). By combining the collagen, which has good biocompatibility and an effect of promoting tissue repair, with PLCL, which is biodegradable and features excellent mechanical properties and good cell adhesion, the collagen membrane not only has an extracellular matrix-like structure, but also exhibits good structural stability, facilitating the regulation of cell behaviors and tissue regeneration, and effectively promoting the growth, adhesion, and proliferation of host cells, thereby inducing ordered remodeling of tissues.

The invention relates to a fracturing technology, in particular to a modified nano lactide material, a preparation method and application thereof and fracturing fluid. According to the modified nano lactide material, in liquid polyethylene glycol with the molecular weight of 380-430, the hydrodynamic diameter D10 of a molecular aggregate is 15-25 [mu] m, the hydrodynamic diameter D50 is 60-90 [mu] m, and the hydrodynamic diameter D90 is 160-190 [mu] m. The preparation method of the modified nano lactide material comprises the following steps: carrying out hydroxylation treatment and activation treatment on a nano microsphere lactide raw material, and contacting with a fluorine-containing surfactant. The modified nano lactide material has excellent degradation performance at a low temperature, meets the low-temperature construction requirement, and can effectively block pores of various sizes when being applied to a fracturing fluid system.

The invention discloses a dual stimuli-responsive polymer micelle as well as a preparation method and application thereof. The micelle is jointly formed by a phenylboronic acid modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer and a catechol modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer, wherein the phenylboronic acid modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer is used for modifying the phenylboronic acid; when the micelle is formed, pH and ROS can be formed in a hydrophobic core to stimulate corresponding boric acid ester bonds; the micelle is used for loading hydrophobic antitumor drugs. The polymer micelle prepared by the invention can be stable in an in-vivo circulating physiological environment, and makes stimulation response to a tumor microenvironment to cause structure loosening or dissociation, so that effective delivery of hydrophobic antitumor drugs is realized, the problems of instability of the micelle in vivo and drug pre-leakage are effectively solved, and the drug delivery efficiency is improved. Theoretical and practical basis is provided for promoting cancer treatment of a polymer micelle drug delivery system.

The invention belongs to the technical field of biological medicine, and particularly relates to peptide slow-release temperature-sensitive hydrogel as well as a composition, a preparation method and application thereof. The composition consists of a hydrogel monomer polymer and biological peptide, wherein the biological peptide is Leucokinin VIII, and the biological peptide is Leucokinin VIII The hydrogel monomer polymer is prepared by mixing and heating polyethylene glycol, lactide and stannous zincate. The preparation method of the peptide slow-release temperature-sensitive hydrogel comprises the following steps: mixing polyethylene glycol, lactide and stannous zincate, and carrying out heating and stirring reaction to prepare a hydrogel monomer polymer; and then mixing the hydrogel monomer polymer with the Leucokinin VIII, so as to obtain the peptide slow-release temperature-sensitive hydrogel. The peptide sustained-release temperature-sensitive hydrogel has the advantages of excellent temperature-sensitive characteristic, injectability, drug sustained-release performance, biocompatibility and biological safety.

The invention relates to the technical field of polyester degradable plastics, and discloses a biodegradable shrink film as well as a preparation method and application thereof. The preparation method of the biodegradable shrink film comprises the following steps: reacting (R)-3-hydroxybutyric acid with 1, 4-dibromobutane to obtain a dihydric alcohol monomer; the preparation method comprises the following steps: copolymerizing a dihydric alcohol monomer and L-lactide to obtain modified polylactic acid; carrying out copolymerization on the geraniol-based compound and L-lactide to obtain a bio-based plasticizer; modifying the bio-based plasticizer with allyl trimethyl ammonium chloride to obtain a modified bio-based plasticizer; the biodegradable shrink film is prepared by taking modified polylactic acid, poly (butylene adipate-co-terephthalate), a modified bio-based plasticizer, a functional filler and palm wax as raw materials. The biodegradable shrink film has the advantages of flexibility, shrinkage performance, lasting antibacterial performance and good barrier performance, and can be used in food packaging materials.

The invention discloses a preparation method of antibacterial modified polylactic acid for a packaging material, and belongs to the technical field of functional modification of polylactic acid.The preparation method comprises the steps that an antibacterial barrier type polylactic acid composite material is prepared through ring opening polymerization of an initiator, grafting of antibacterial molecules and blending of montmorillonite, a chlorine-terminated initiator is generated from ethanolamine and chloroacetyl chloride, and the antibacterial modified polylactic acid is prepared; the preparation method comprises the following steps: initiating ring-opening polymerization of L-lactide to form polylactic acid with terminal group activity, covalently grafting terminal group chlorine with an antibacterial modifier through nucleophilic substitution, endowing the polylactic acid with antibacterial property, coupling modified montmorillonite with silane through organic intercalation, and then carrying out melt blending with the modified polylactic acid with antibacterial property to form a layered barrier structure and enhance interface bonding. Therefore, the film has the advantages of high barrier property, high tensile strength, excellent antibacterial activity and good degradability.

The invention relates to the field of cosmetics, and discloses a moisturizing and anti-aging micro-capsule composition for cosmetics and a preparation method thereof.The micro-capsule composition comprises a dispersion matrix and a flexible bead, and the flexible bead comprises an active material and a micro-capsule wall, the active materials comprise a centella asiatica extract, a cynanchum atratum extract, an olive leaf extract, a scutellaria baicalensis extract and glycerol tri (ethylhexanoate) ester, and the microcapsule wall comprises soybean lecithin, modified polylactic acid, chondrus crispus and calcium alginate. The modified polylactic acid is prepared by carrying out graft copolymerization reaction on chitosan and L-lactide in chlorinated 1-butyl-3-methylimidazole and then carrying out graft modification by using L-arginine, the active material is wrapped in the capsule wall of the microcapsule to form the flexible bead, and the flexible bead is uniformly suspended in the dispersion matrix; the cosmetics are endowed with better anti-wrinkle and moisturizing effects.

A stable sustained release injectable formulation based on poly(D,L-lactide-co-glycolide) microparticles comprising levothyroxine is described. The formulation has a theoretical levothyroxine loading of at least 1.5% w / w. A process for preparing the microparticles is also described. The formulation may be used to control hypothyroidism in adults, congenital hypothyroidism in infants, and acquired hypothyroidism in children.

The invention discloses a method for selectively depolymerizing polylactic acid into chiral lactide, and belongs to the technical field of polylactic acid depolymerization. According to the invention, the problems that the existing conventional polylactic acid depolymerization means generally lacks stereoselectivity and a depolymerization product with high optical purity is difficult to obtain are solved. In the presence of a solvent and under the heating condition, polylactic acid matched with chirality is depolymerized into lactide with high optical purity under the catalysis of a chiral depolymerization catalyst, and polylactic acid not matched with chirality is not depolymerized, so that the selective depolymerization process of polylactic acid is realized. Different from the traditional asymmetric catalysis field, the method focuses on recognition of small molecules, realizes closed-loop depolymerization of polylactic acid to chiral monomers, realizes selective recognition and depolymerization of chiral polymers, and broadens the research range of asymmetric catalysis.

The invention belongs to the technical field of surgical article materials, and particularly relates to a collagen membrane with an effect of inducing ordered remodeling of tissues as well as a preparation method and application of the collagen membrane. The collagen membrane is obtained by performing hot pressing treatment on a fiber membrane; the fiber membrane is formed by crossing and laminating fibers with the diameter of 0.5-15 microns; the fiber comprises collagen and poly (L-lactide-caprolactone), and the mass ratio of the collagen to the poly (L-lactide-caprolactone) is 1: (1.5-2.5). The collagen membrane provided by the invention combines collagen with good biocompatibility and a tissue repair promoting effect with biodegradable PLCL with excellent mechanical properties and good cell adhesion, not only has an extracellular matrix-like structure, but also has good structural stability, is beneficial to regulation of cell behaviors and tissue regeneration, and can be used for preparing the collagen membrane. The growth, adhesion and proliferation of host cells can be effectively promoted, so that ordered remodeling of tissues is induced.

The invention relates to an aqueous solution of an mPEG modified polyester material as well as a preparation method and application thereof, and belongs to the technical field of materials. The invention provides an aqueous solution of an mPEG modified polyester material. The polyester material is formed by polymerizing at least one monomer of L-lactide, epsilon-caprolactone, glycolide and p-dioxanone. The mPEG modified polyester material is a diblock copolymer or a triblock copolymer; the content of the mPEG modified polyester material in the aqueous solution is 10-28% w / w, and the aqueous solution contains phosphate with the concentration of 9.86 mmol / L to 0.12 mol / L. By adding phosphate with a specific concentration, the prepared nano-micelle aqueous solution has the advantages of small particle size, uniform particle size distribution, high stability, good dispersibility and ductility after injection, good histocompatibility, good skin filling and collagen regeneration effects, low incidence rate of adverse reactions and the like.

The invention belongs to the technical field of high polymer materials, and discloses copolyester based on 4-aryl-epsilon-caprolactone and lactide as well as a preparation method and application of the copolyester. The copolyester is composed of a lactide structural unit and a 4-aryl-epsilon-caprolactone structural unit. A rigid benzene ring is introduced into a molecular chain, so that the synergistic balance of toughness and rigidity is successfully realized, and the toughness is remarkably improved while the high strength of the material is maintained. In addition, the introduction of phenyl endows the material with intrinsic ultraviolet resistance, the material can be used as an efficient ultraviolet absorbent, protective spherical protrusions are formed on the surface of the material under ultraviolet irradiation, and photooxidative degradation is effectively delayed. The material can be widely applied to the fields of high-performance degradable packaging, biomedical materials, outdoor articles, textiles and the like.

The invention discloses an absorbable suture line containing fibroin and a preparation method of the absorbable suture line, and relates to the technical field of absorbable suture lines. The absorbable suture line containing the silk protein is prepared from the following raw materials in parts by weight: 35 to 50 parts of silk protein, 10 to 20 parts of polylactic acid, 15 to 25 parts of polyglycolide-lactide, 1 to 3 parts of antibacterial agent, 2 to 5 parts of modified toughening agent, 1 to 4 parts of nano mineral filler, 0.5 to 2 parts of cross-linking agent and 2 to 5 parts of plasticizer, the preparation method comprises the following steps: reacting protocatechuic acid with ethanolamine to generate an intermediate 1; and reacting the intermediate 1 with 5, 10, 15, 20-tetra (4-carboxyl phenyl) porphyrin to generate the antibacterial agent. The prepared absorbable suture line containing the silk protein has good mechanical performance, self-repairing performance and antibacterial performance.

The invention provides an L-lactide purification device and an L-lactide purification method. The L-lactide purification device comprises a crystallization unit, an evaporation unit, a condensation unit and an extraction unit, the crystallization unit is at least used for crystallizing, sweating and melting the raw materials to form L-lactide and crystallization raffinate; the inlet of the evaporation unit is communicated with the crystallization residual liquid outlet of the crystallization unit, and the evaporation unit is at least used for evaporating the crystallization residual liquid to form evaporation gas; an inlet of the condensation unit is communicated with a gas phase outlet of the evaporation unit, and the condensation unit is at least used for condensing the evaporation gas to form condensate; a liquid phase inlet of the extraction unit is communicated with a liquid phase outlet of the condensation unit, and the extraction unit is at least used for extracting condensate to form a first component containing L-lactide; the outlet of the extraction unit is communicated with the crystallization unit, so that the crystallization unit adopts the first component as a raw material for crystallization. According to the embodiment of the invention, the yield of the L-lactide can be improved, and the L-lactide with high chemical purity and high optical purity can be obtained.

The invention relates to use of a polymer (I) as a precursor of a shape-memory polymer, wherein the polymer (I) comprises a backbone which is end-capped by a crosslinkable end-capping unit comprising a moiety having a crosslinkable functionality, wherein the backbone comprises a copolymer of a cyclic carbonate selected from the group consisting of trimethylene carbonate, ethylene carbonate, propylene carbonate, styrene carbonate and glycerol carbonate and a comonomer selected from the group consisting of ε- caprolactone, α-acetolactone, β-propiolactone, γ-butyrolactone, δ- valerolactone, β-butyrolactone, γ-caprolactone, γ-octalactone, γ-nonalactone, δ- decalactone, γ-decalactone, ω-pentadecalactone, diglycolic anhydride, glycolide,lactide, norcamphor lactone, verbanone lactone, dihydrocarvide, wherein the lactone is unsubstituted or substituted by halogen or C1-C12 alkyl, and combinations thereof.

The present application relates to the field of biological glass, in particular to a kind of composite biological glass and its preparation method and application.The present application uses rhBMP-2, doped antibacterial ion 45S5 bioactive glass and polyethylene glycol-lactide-glycolide polymer compound preparation slow-release antibacterial biological glass, the rhBMP-2 can occur synergistic effect with doped antibacterial ion 45S5 bioactive glass, compared with homologous growth factor can play more optimal synergy with antibacterial ion, so as to have higher antibacterial property and osteogenesis, while having longer slow-release effect in polyethylene glycol-lactide-glycolide polymer.The composite biological glass provided by the present application overcomes the pain points of the prior art for the treatment of oral bone defect, improves the treatment effect, reduces the amount of antibiotic use, and reduces the risk of infection.

The present invention provides a lactide purification method, which comprises: (1) mixing an alcohol and / or ester solvent with crude lactide, and dissolving to obtain a crude lactide solution; and (2) adding water into the crude lactide solution, carrying out heat preservation, mixing and cooling to separate out lactide, carrying out solid-liquid separation to obtain a solid, and washing and drying the solid to obtain a lactide product. According to the method, the characteristic that the solubility of the lactide in an alcohol / ester solvent is in nonlinear growth is utilized, the lactide is completely dissolved firstly, then water is added for cooling and precipitation, m-lactide is hydrolyzed at the same time, then cooling is performed to enable the lactide to be continuously precipitated, and finally the powder-state lactide is obtained, so that the whole process avoids the formation of large blocks in the product, no impurity inclusion exists, and the purity of the product is greatly improved. The product quality is more uniform, the particle size range is kept at 50 + / -10 microns, the problems that a stirring paddle is damaged and a pipeline is blocked due to the existence of large blocks are avoided, and the conveying problem in engineering is solved.

Provided are compositions that include a histone deacetylase inhibitor (HDACi) encapsulated in and / or otherwise associated with a nanoparticle. In some embodiments, the HDACi is romidepsin, vorinostat, belinostat, panobinostat, and / or chidamide. In some embodiments, the nanoparticle is a poly(D,L-lactide)-PEG-methyl ether (mPEG-PDLLA) nanopolymer. Also provided are methods for treating diseases, disorders, and / or conditions associated with sensitivity to histone deacetylase inhibitors, such as but not limited to tumors and / or cancers; and methods for inhibiting the growth, proliferation, and / or metastasis of a tumor and / or a cancer associated with sensitivity to histone deacetylase inhibitors by administering an effective amount of a composition as disclosed herein, which methods can optionally include administering at least one additional therapeutically active agent, such as but not limited to a chemotherapeutic agent.

The present invention discloses a method for chemically recycling PLA-containing blended plastics, belonging to the technical field of plastic degradation and recycling. The present invention solves the problem that the existing chemical recycling methods cannot meet the separation and recycling of PLA-containing blended plastics. The present invention heats and depolymerizes the PLA-containing blended plastics in a polar organic solvent under the catalysis of a zinc-based or magnesium-based catalyst to obtain the depolymerization product lactide monomer of polylactic acid, and directly separates to obtain other blended components. The recycling process provided by the present invention has mild reaction conditions, the catalyst used is environmentally friendly, the purity of the recovered lactide monomer reaches more than 99%, and at the same time, the efficient and high-yield separation and recycling of other components in the mixed plastics are realized, which is of great significance to environmental protection and the research on the utilization of waste plastics.

The invention relates to a process for recycling polylactic acid (PLA) into lactic acid, comprising the steps of: a) hydrolysing a PLA waste thereby obtaining a crude lactic acid composition; b) diluting the crude lactic acid composition in water, thereby producing a diluted crude lactic acid composition; c) equilibrating the diluted crude lactic acid composition for a equilibration period te at a equilibration temperature of at least Te, thereby producing an equilibrated crude lactic acid composition; d) concentrating the equilibrated crude lactic acid composition, thereby producing a concentrated crude lactic acid composition; e) optionally, distilling the concentrated crude lactic acid composition thereby producing a distilled lactic acid composition; and f) crystallizing the concentrated crude lactic acid composition obtained in step d), or the distilled lactic acid composition obtained in step e), thereby recovering lactic acid. The invention also relates to lactic acid obtained when carrying out the process of the invention and their use in the preparation of lactide and / or polylactide.

The invention provides a degradable fiber temporary plugging agent and a preparation method thereof, and belongs to the technical field of oil-gas field development. The temporary plugging agent is composed of polylactic acid-polyurethane block copolymer fibers, and the preparation method of the temporary plugging agent comprises the steps that S1, lactide and an initiator containing dihydroxyl are subjected to ring opening polymerization under the action of a first catalyst, and a hydroxyl-terminated prepolymer is formed; s2, reacting the prepolymer with diisocyanate under the action of a second catalyst to synthesize a polylactic acid-polyurethane block copolymer; s3, preparing fibers through a melt spinning or electrostatic spinning process; the degradation rate and the mechanical property of the fiber can be regulated and controlled by regulating and controlling the initiator type, the diisocyanate type, the isocyanato index R value and the catalyst dosage, so that the fiber is suitable for the wide-temperature-range reservoir conditions of 45-120 DEG C, and the technical problems of contradiction between the strength and the degradability, narrow temperature adaptability, secondary damage to the reservoir and the like of a traditional temporary plugging agent are effectively solved.

The invention belongs to the technical field of block copolymers, and particularly relates to an amphiphilic block copolymer, a stereocomplex and a preparation method and application of the amphiphilic block copolymer and the stereocomplex. The amphiphilic block copolymer contains a polyester block and a water-soluble polymer block, and by forming a monomer of the polyester block, on the premise that raw materials such as D, L-lactide serve as first monomers, a second monomer with stereoregularity is introduced, so that the stability of the amphiphilic block copolymer can be improved, and meanwhile, the water solubility or self-dispersity of the amphiphilic block copolymer is still kept; and micelle or nano-particles are formed, and high drug loading capacity is maintained.

The invention relates to a separation qualitative and quantitative detection method for L-lactide, D-lactide and Meso-lactide, and belongs to the field of lactide optical purity detection.The separation qualitative and quantitative detection method comprises the following steps that firstly, various lactide standard curves of different configurations are established respectively, the concentration range of the standard curves is 10-1000 mg / L, and the concentration range of the standard curves is 10-1000 mg / L; the plurality of lactides with different configurations comprise one or more of L-lactide, D-lactide and Meso-lactide; and the lactide with different configurations comprises one or more of the L-lactide, the D-lactide and the Meso-lactide. 2, detecting by using a gas chromatograph-mass spectrometer, and quantitatively calculating a lactide substance to be detected, wherein the concentration range of the lactide substance to be detected is 200-1000mg / L; according to the invention, separation and quantitative detection of three lactide optical isomers are realized by using an analysis method; the influence of impurities in the to-be-detected substance of lactide on the accuracy of the quantitative result of lactide is reduced; qualitative and semi-quantitative information of the impurities in the to-be-detected substance is provided.