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6118 results about "Mole ratio" patented technology

A mole ratio is ​the ratio between the amounts in moles of any two compounds involved in a chemical reaction. Mole ratios are used as conversion factors between products and reactants in many chemistry problems.

Wound healing polymer compositions and methods for use thereof

The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyrate-valerate copolymers, and copolymers of the cyclic diester monomer, 3-(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and ε-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.
Owner:MEDIVAS LLC

Method for preparing salvianolic acid A by catalytically converting salvianolic acid B

The invention discloses a method for preparing salvianolic acid A by catalytically converting salvianolic acid B. The method is characterized in that the converted raw material is a salvia miltiorrhiza aqueous extract (salvianolic acid B=>50%) primarily purified through combined chromatography; the concentration of the raw material salvianolic acid B is 0.5-2%; urea is taken as the catalyst; the mole ratio of urea to the salvianolic acid B is 0.3-0.7; the conversion reaction temperature is 100-125 DEG C; and the reaction time is 3-6 hours. The method has the following beneficial effects: urea is taken as the catalyst, thus greatly shortening the time for which the salvianolic acid B is in easily destroyed state and remarkably increasing the yield of the salvianolic acid A; the primarily purified salvia miltiorrhiza extract is taken as the converted raw material, thus not only removing the metal ions which are not beneficial to conversion but also removing most colloid-like impurities and frontal impurities which are not beneficial to following separation of the salvianolic acid; and the directional conversion rate of the salvianolic acid B to the salvianolic acid A prepared by the method is not less than 10% and even reaches 60%.
Owner:SUZHOU LEINA PHARMA RES DEV +1
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