125results about "Organic compounds purification/separation/stabilisation" patented technology

The invention discloses an in-situ acetylation-co-crystallization method and application of the in-situ acetylation-co-crystallization method in organic molecular structure determination, and the in-situ acetylation-co-crystallization method comprises the following steps: synthesizing a cyclic trinuclear silver (I) complex as a crystallization partner, and carrying out an in-situ acetylation reaction in an organic molecular sample, after the reaction is completed, adding a crystallization partner for co-crystallization; the application of the in-situ acetylation-co-crystallization method in the determination of the organic molecular structure comprises the following steps: preparing a co-crystal from an organic molecule to be detected through the in-situ acetylation-co-crystallization method, collecting crystallographic data of the co-crystal, and analyzing to obtain a crystal structure of an acetylation product of the organic molecule to be detected; and determining the chemical structure and the spatial configuration of the to-be-detected organic molecule according to the crystal structure of the to-be-detected organic molecule acetylation product. The method can be used for structure determination of a series of acetylated organic molecules such as alcohols, phenols, amines and the like.

The invention belongs to the technical field of biological fermentation, and provides a microbial fermentation efficient extraction process and device, and the process comprises the following steps: step 1) continuous disinfection; the method comprises the steps of (1) fermentation, (2) fermentation culture, (3) cross-tank conveying, (4) temperature control and high-pressure recovery, (5) split-flow extraction and purification and (6) refining and drying, the quality of fermentation liquor is improved through a fermentation process precise control technology and a new fermentation technological process, and the product yield is improved through an efficient extraction technology.

The present invention provides a method for synthesizing a key intermediate compound represented by formula (II) of a selective THR beta agonist. Raw materials used in the method are inexpensive and readily available, the process is simple and efficient, no SFC chiral separation is required, the yield is high, quality and costs are controllable, and the method has great industrial prospects.

To provide enhanced systems and methods of chemical synthesis that reduce or eliminate the amount of fuel, particularly fossil fuel, that is burned to provide energy.SOLUTION: A chemical synthesis plant comprising a reactor configured for producing a process stream comprising a chemical product from a reactant; a feed preparation system configured to prepare a feed stream of the reactant for introduction into the reactor; and / or a product purification system configured to separate the chemical product from a reaction byproduct, unreacted reactant, or a combination thereof within the process stream, wherein the chemical synthesis plant is configured such that a majority of the net energy required for heating, cooling, compression, or a combination thereof utilized via the reactor, the feed preparation system, the product refining system, or a combination thereof is supplied from the intermittent energy source (IES).SELECTED DRAWING: Figure 3

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

The invention relates to a method and installation for recycling a mixture comprising at least one fluorinated fluid, the mixture comprising one or more fluorinated chemical components and one or more contaminants selected from one or more hydrocarbons and / or one or more fluorinated contaminants, including a double membrane filtration step to reduce the contaminant content of the mixture. Figure for the abstract: Figure 1

The present disclosure relates to a liquid composition, an adjuvant composition, and a concentrate solute composition. The liquid composition comprises an organic solute, a water- immiscible solvent, an aliphatic water-insoluble alcohol, and optionally water. The adjuvant composition comprises a water-immiscible solvent and an aliphatic water-insoluble alcohol. The concentrate solution composition comprises an organic solute, a water-immiscible solvent, and an aliphatic water-insoluble alcohol. The present disclosure relates to a method for suppressing volatility of organic solutes from their aqueous solutions.

An inhibitor composition is provided for mitigating undesired polymerization in the vapor space during the purification of reactive vinyl monomers. The polymerization inhibitor composition includes at least a first inhibitor compound having a stable nitroxide radical and a second inhibitor comprising a phenylenediamine. Methods of inhibiting polymerization of monomers in a vapor space using the disclosed compositions are also provided.

The present application belongs to the technical field of depolymerization separation, and particularly relates to a method for separating polyphenolic compounds from lignin depolymerization products, the polyphenolic compounds and applications thereof. The lignin depolymerization products are mixed with an extraction liquid for extraction, the extraction products are mixed with the extraction liquid for extraction, then the obtained upper extraction liquid is cooled for crystallization, and countercurrent chromatography separation is performed to remove phenol in the depolymerization liquid. On this basis, the polyphenolic compounds are obtained through high-pressure preparation separation technology. The polyphenolic compounds obtained by the present application are functional components, and are new antioxidant active compositions. The polyphenolic compounds have high free radical scavenging rate and excellent antioxidant activity. Meanwhile, the polyphenolic compounds are lignin polyphenolic nanomicelles with fluorescence performance. The micelles can obtain strong fluorescence under a relatively short excitation wavelength. The polyphenolic compounds also have excellent anticancer activity.

To provide an alkylamine composition and a method for storing the alkylamine composition.SOLUTION: The alkylamine composition contains 99.5% by volume or more of an alkylamine represented by the following formula (1) and 10 ppm by mass or more and 100 ppm by mass or less of water. (In the formula, N represents a nitrogen atom; R1 represents a C1 to 10 hydrocarbon group which may have a ring, a hetero atom, or a halogen atom; R2 and R3 each independently represent H or a C1 to 10 hydrocarbon group which may have a ring, a hetero atom, or a halogen atom; However, when the number of carbon atoms is 3 or more, the hydrocarbon group may have a branched-chain structure or a cyclic structure. The hetero atom of the hydrocarbon group is a nitrogen atom, an oxygen atom, a sulfur atom, or a phosphorus atom. In addition, R1 has one or more hydrogen atoms at an α - position carbon atom. ) SELECTED DRAWING: None

The sludge separator of the present invention comprises a barrier layer having a plurality of barrier units spaced apart from each other, and thus the sludge separator has excellent performance and can prevent a gas flow path from being blocked. The NMP purification method and apparatus using the sludge separator can improve the recovery rate of NMP recovered from waste NMP, thereby providing high-purity NMP.

The disclosure provides certain porous polymeric membranes, coated with cross-linked polymerized monomers, comprising monomers having a charge when immersed in an organic liquid. The membranes of the disclosure are useful in removing trace amounts of metallic impurities thereby providing ultra-pure organic liquids.

Disclosed are crystalline forms of a compound of Formula (I). Also disclosed are pharmaceutical compositions comprising a crystalline form of the compound of Formula (I), and a crystalline form of a compound of Formula (I) for use in the treatment or prophylaxis of a GPR17-associated disease, such as multiple sclerosis.

The invention relates to the technical field of daily chemical products, in particular to a method for solving non-discoloration of hinokitiol and hinokitiol analogues, during specific use, sodium hydrogen sulfite or sodium hydrogen sulfite analogues are adopted to solve the discoloration of hinokitiol and hinokitiol analogues; a sodium hydrogen sulfite solution or a sodium hydrogen sulfite analogue solution is adopted to solve the problem of discoloration of daily chemical products containing hinokitiol and hinokitiol analogues; in this way, the technical problem that in the prior art, the hinokitiol and hinokitiol analogues are discolored in the processes of vacuum preservation and direct addition to daily chemical products for use is solved.

The present invention relates to a method of stabilizing (storing and pre-treating) a high-purity FP-CIT linear precursor and a method of preparing [F]FP-CIT using the FP-CIT linear precursor. 18 If the FP-CIT linear precursor is stored using the organic solvent having the characteristics according to the present invention, the FP-CIT linear precursor is inhibited from being converted into a cyclic salt form or degraded into various compounds, so that a high-purity FP-CIT linear precursor can be maintained, and a radiopharmaceutical can be prepared by using the existing [F]FP-CIT labeling conditions as they are [F]FP-CIT, 18 Therefore, the present invention can be effectively used as a starting material for [F]FP-CIT. 18 18 ​​

The invention relates to the technical field of chip manufacturing, in particular to ion exchange resin, a synthesis method thereof and a purification method of an electronic-grade solvent. The synthesis method of the ion exchange resin comprises the following steps: mixing a monomer A, a monomer B, elemental sulfur and an organic solvent to obtain a first mixture; heating the first mixture in a protective atmosphere to obtain a second mixture; purifying the second mixture to obtain ion exchange resin; wherein R1 is selected from a sulfonic group or a carboxyl group, and R2 is selected from a substituted or unsubstituted alkenyl group or a substituted or unsubstituted acrylate group; r3 and R4 are selected from H, substituted or unsubstituted alkyl or substituted or unsubstituted acrylate groups, and R5 and R6 are selected from substituted or unsubstituted acrylate groups. The ion exchange resin can reduce the metal ion content of a solvent to 0.1 ppb or less.

The present invention allows for an efficient production of a carboxylic acid, by providing a method of producing a carboxylic acid, which includes the following steps (A) and (B): (A) filtering a carboxylic acid-containing fermentation broth by passing said fermentation broth through a nanofiltration membrane, to obtain a carboxylic acid-containing filtrate from the permeate side of the membrane; and (B) extracting the carboxylic acid from the carboxylic acid-containing filtrate obtained in the step (A) using an extraction solvent which undergoes phase separation with the filtrate, and collecting a carboxylic acid extract phase-separated from the aqueous phase.

The present invention aims to provide a compound purification apparatus capable of providing a high purity compound in high yield and at low cost. The present invention relates to an apparatus for purifying a compound, the purification apparatus including: a crystallizing unit including a crystal forming section; and a wash column including a mechanism that forcibly transfers crystals, the crystallizing unit including N tanks connected in series, wherein N is 2 or greater, a 1st tank is a most downstream tank, a (N)th tank is a most upstream tank, at least the 1st tank is a crystallization tank including a cooling mechanism, and a 2nd and subsequent tanks are each a crystallization tank or a ripening tank, the purification apparatus including a line that feeds a compound-containing liquid to be purified to at least one of the N tanks, the wash column including: a line that sends a product out; and a line that returns a mother liquor to the crystallizing unit, with the line that returns a mother liquor to the crystallizing unit being connected to at least the (N)th tank, the crystallizing unit including: a line that feeds a slurry from the (N)th tank to the wash column; a line that sends a slurry from a tank among the 1st to (N - 1)th tanks to the next upstream tank; and a line that is provided to each of the 1st to (N - 1)th tanks and that sends thereto a mother liquor withdrawn from an upstream tank, wherein at least one of the lines that send a slurry from a tank among the 1st to (N - 1)th tanks to the next upstream tank is a line that sends a slurry from a tank to the next upstream tank via a solid-liquid separator and that has a line that returns a mother liquor from which crystals are removed in the solid-liquid separator to the tank where the slurry came from, and wherein the line that is provided to each of the 1st to (N - 1)th tanks and that sends thereto a mother liquor withdrawn from an upstream tank is a line that directly sends a mother liquor withdrawn from a tank one upstream or a line that sends a mother liquor withdrawn from a tank one upstream via a solid-liquid separator, the purification apparatus further including a line that sends a mother liquor to the outside of the purification apparatus.

To provide a manufacturing method for vinylsilane gas which continuously refines vinylsilane gas, and inexpensively and safely fills high purity vinylsilane gas obtained by this result, and a manufacturing apparatus for the same.SOLUTION: A manufacturing method for vinylsilane gas includes a generation step of generating vinylsilane, a refining step of refining the generated vinylsilane, and a filling step of filling a filling container with the refined vinylsilane. The refining step includes a first refining step of separating a high boiling point substance from the vinylsilane generated in the generation step, and returning the separated high boiling point substance to the generation step, and a second refining step of further separating a high boiling point substance from the separated vinylsilane. The filling step cools the filling container to a temperature equal to or lower than a solidification point of the vinylsilane, fills the filling container with the vinylsilane, and removes a low boiling point substance from the solidified vinylsilane.SELECTED DRAWING: Figure 1

To provide a device and method for optimizing solid phase extraction (SPE) purification conditions for the isolation of a compound from a composition containing the compound, preferably from a crude reaction mixture.SOLUTION: A cassette comprises: (i) a flowpath comprising a first end and a second end; and (ii) a plurality of valves arranged along the flowpath, where each of the valves is selectively fluidly connected to one of a number of components. The components comprise: (a) 1-5 composition vials; (b) 1-3 SPE cartridges; (c) 4-10 solvent vials; (d) a water vial; and (e) a transfer line.SELECTED DRAWING: Figure 1

Provided is a method for preparing an ester-based composition using a continuous reaction system in which a plurality of reactors are connected in series, wherein the heat transfer performance, reactor productivity, and total reactor productivity can be improved by controlling operating conditions.

To provide a method for treating a disease. [Solution] The present invention relates to the large-scale production of psilocybin for use in pharmaceuticals. More specifically, the present invention relates to a method for obtaining high-purity crystalline psilocybin, particularly in the form of polymorph A. The present invention further relates to a method for producing psilocybin, intermediates in its production, and formulations containing psilocybin. Large-scale means producing batches of psilocybin having a weight greater than 10 g, more preferably greater than 100 g, more preferably greater than 250 g, and up to and above the kilogram level.

The present disclosure relates to crystalline polymorphs of the compound of Formula (I), namely N-(4-bromo-2,5-difluorophenyl)-6-chloro-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide: [Refer to original abst

An ammonia synthesis plant comprising: a feed pretreating section operable to pretreat a feed stream; a syngas generation section operable to reform the feed stream to produce a reformer product stream; a shift conversion section operable to subject the reformer product stream to the water gas shift reaction, to produce a shifted gas stream comprising more hydrogen than the reformer gas stream; a purification section operable to remove at least one component from the shifted gas stream, and provide an ammonia synthesis feed stream; and / or an ammonia synthesis section operable to produce ammonia from the ammonia synthesis feed stream, wherein the ammonia synthesis plant is configured such that, relative to a conventional ammonia synthesis plant, more of the energy required by the ammonia synthesis plant or one or more sections thereof is provided by a non-carbon based energy source, a renewable energy source, and / or electricity.

The invention discloses a composition of a samarium-oxygen / hydroxyl cluster compound and a thiol compound. The samarium-oxygen / hydroxyl cluster compound and the thiol compound are compounded to achieve synergistic interaction. The invention also discloses an application of the composition in antioxidants, and particularly relates to an application in inhibition of auto-oxidation of aromatic aldehyde and removal of DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radicals. An antioxidant experiment result shows that the composition is excellent in antioxidant activity and can be deeply developed and applied in the fields of food, medicine and chemical engineering as a novel antioxidant.

A 1,4-dioxane solvate of lithium difluoro bis(oxalato)phosphate, a method for preparing the same, and an electrolyte composition containing the same are disclosed. The 1,4-dioxane solvate of lithium difluorobis(oxalato)phosphate has excellent crystallinity and filterability, so that a compound with high purity can be obtained in high yield. Further, since it has excellent stability against moisture, its distribution and storage are easy and the stability of the composition containing 1,4-dioxane solvate of lithium difluoro bis(oxalato)phosphate can be greatly improved.