212results about "Organic compounds purification/separation/stabilisation" patented technology

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

The invention provides a synthesis method of a selective THRbeta agonist key intermediate compound as shown in the formula (II). The synthesis method has the advantages of cheap and easily available raw materials, simple and efficient process, no need of SFC chiral resolution, high yield, controllable quality and cost, and huge industrialization prospect.

Inhibitor compositions for abating undesirable emulsion polymerization during processing of hydrocarbon stream laden with reactive vinylic monomers are provided. The polymerization inhibitor compositions include at least a first inhibitor compound having a stable nitroxide radical and a second inhibitor including phenylenediamine. Methods of inhibiting the polymerization of monomers using the compositions of the disclosure are also provided. The methods of inhibiting polymerization of monomers include a step of adding a composition of the disclosure to a process stream. The process stream includes an ethylenically unsaturated monomer that is suspended in the bulk-phase and highly polar solvents as distractive distillation solvents.

The invention discloses nano composite hydrogel modified silica gel as well as a preparation method and application thereof. The method comprises the following steps: (1) preparing carbon nanoparticles; (2) preparing a polyvinyl alcohol aqueous solution and a pre-polymerized solution of carbon nanoparticles and hydrogel; (3) preparation of nano-composite hydrogel modified silica gel: adding the pre-polymerized liquid and silica gel into the polyvinyl alcohol aqueous solution under stirring, adding an initiator, carrying out hot bath, carrying out condensation reflux in an inert atmosphere for reaction, and then adding a polyvinyl alcohol cross-linking agent and an HCl aqueous solution for reaction; and after the reaction is finished, centrifugally washing and drying to obtain the nano-composite hydrogel modified silica gel. The nano-composite hydrogel modified silica gel has excellent hydrophilicity, can be used as a hydrophilic mode liquid chromatography filler, and has great development space and application potential in the field of chromatographic separation and analysis.

An apparatus includes a distillation container configured to receive a mixture. The apparatus includes a column fluidly connected to the distillation container. A mesh is disposed in the column. The apparatus includes a plurality of conduits fluidly connected to respective vacuums. A fractionating head is fluidly connected to the column. The column is fluidly connected between the distillation container and the fractionating head.

A chemical synthesis apparatus comprising: one or more reactors configured to produce a process stream comprising at least one chemical product from one or more reactants; a feed preparation system configured to prepare one or more feed streams comprising one or more of one or more reactants to be introduced into one or more reactors; and / or a product purification system configured to separate at least one chemical product from reaction byproducts, unreacted reactants, or a combination thereof within the process stream, wherein the chemical synthesis apparatus is configured such that a majority of the net energy required for heating, cooling, compression, or a combination thereof used via one or more reactors, feed preparation systems, product purification systems, or a combination thereof is provided by a non-carbon-based energy source, renewable energy source, and / or electrical power.

The invention discloses an in-situ acetylation-co-crystallization method and application of the in-situ acetylation-co-crystallization method in organic molecular structure determination, and the in-situ acetylation-co-crystallization method comprises the following steps: synthesizing a cyclic trinuclear silver (I) complex as a crystallization partner, and carrying out an in-situ acetylation reaction in an organic molecular sample, after the reaction is completed, adding a crystallization partner for co-crystallization; the application of the in-situ acetylation-co-crystallization method in the determination of the organic molecular structure comprises the following steps: preparing a co-crystal from an organic molecule to be detected through the in-situ acetylation-co-crystallization method, collecting crystallographic data of the co-crystal, and analyzing to obtain a crystal structure of an acetylation product of the organic molecule to be detected; and determining the chemical structure and the spatial configuration of the to-be-detected organic molecule according to the crystal structure of the to-be-detected organic molecule acetylation product. The method can be used for structure determination of a series of acetylated organic molecules such as alcohols, phenols, amines and the like.

The present application relates to allulose crystals, which have an X-ray powder diffraction pattern including peaks at 2θ diffraction angles of 18.8±0.5°, 15.2±0.5°, and 19.5±0.5° in X-ray powder diffraction (XRD) analysis, a sweetener composition containing allulose crystals, and a method for producing allulose crystals.

The invention belongs to the field of separation and purification of bio-based chemicals, and particularly relates to a method for directionally separating organic acid in biomass pyrolytic oil and efficiently purifying levoglucosenone. According to the method, pyrolysis oil obtained by selective pyrolysis of biomass is taken as a raw material, firstly, a medium-polarity extraction agent is utilized to perform two-phase step-by-step fractional extraction on the pyrolysis oil, and a water phase rich in organic acid and an oil phase rich in LGO are respectively obtained; and the water phase is sequentially subjected to alkalization, acidification, filtration and water washing treatment to obtain an organic acid solid. And putting the oil phase into a rectifying tower, separating under the conditions that the temperature is # imgabs0 # and the vacuum degree is 300-2000Pa, and removing an extracting agent, furans and oligomers, thereby obtaining the high-purity LGO. The pyrolytic oil is subjected to coupling treatment of two-phase step-by-step fractional extraction, organic acid extraction and rectification, so that the aim of separating and purifying high-added-value chemicals from the low-value and complex-component pyrolytic oil is fulfilled.

The invention belongs to the technical field of biological fermentation, and provides a microbial fermentation efficient extraction process and device, and the process comprises the following steps: step 1) continuous disinfection; the method comprises the steps of (1) fermentation, (2) fermentation culture, (3) cross-tank conveying, (4) temperature control and high-pressure recovery, (5) split-flow extraction and purification and (6) refining and drying, the quality of fermentation liquor is improved through a fermentation process precise control technology and a new fermentation technological process, and the product yield is improved through an efficient extraction technology.

The present invention provides a free radical polymerization inhibitor, its preparation method and use, and a composition comprising hydroxyethyl methacrylate. The free radical polymerization inhibitor has a boiling point of 350°C or higher. The free radical polymerization inhibitor is applied in the extractive distillation separation process of hydroxyethyl methacrylate, and the content of the free radical polymerization inhibitor in the hydroxyethyl methacrylate product taken to the top of the column is very small, which does not adversely affect the color number and downstream application. The free radical polymerization inhibitor is selected from one or more of the following structures:

The present invention provides a method for synthesizing a key intermediate compound represented by formula (II) of a selective THR beta agonist. Raw materials used in the method are inexpensive and readily available, the process is simple and efficient, no SFC chiral separation is required, the yield is high, quality and costs are controllable, and the method has great industrial prospects.

The present invention relates to an improved process for the preparation of crystalline forms of oxaborole derivatives which are used as agents in the treatment of mild-to-moderate atopic dermatitis. The present invention specifically relates to an improved process for the preparation of crystalline forms of Crisaborole (Form II). The present invention specifically relates to an improved process for the preparation of crystalline forms of Crisaborole (Form II) through crisaborole sodium salt. The present invention specifically relates to an improved process for the preparation of highly pure Crisaborole through crisaborole sodium salt.

An automated distillation system includes a distillation process under vacuum, a sampling device for extracting a vapor sample of distillate, a gas analyzer for measuring a property of the vapor sample, and a controller for analyzing the property and appropriately adjusting one or more parameters of the system, such as a level of vacuum, in response to the analysis.

To provide enhanced systems and methods of chemical synthesis that reduce or eliminate the amount of fuel, particularly fossil fuel, that is burned to provide energy.SOLUTION: A chemical synthesis plant comprising a reactor configured for producing a process stream comprising a chemical product from a reactant; a feed preparation system configured to prepare a feed stream of the reactant for introduction into the reactor; and / or a product purification system configured to separate the chemical product from a reaction byproduct, unreacted reactant, or a combination thereof within the process stream, wherein the chemical synthesis plant is configured such that a majority of the net energy required for heating, cooling, compression, or a combination thereof utilized via the reactor, the feed preparation system, the product refining system, or a combination thereof is supplied from the intermittent energy source (IES).SELECTED DRAWING: Figure 3

The present disclosure relates to a process for the preparation of Acarrabutinib. The present disclosure relates generally to an improved process for the preparation of 4-{8-amino-3-[(2S)-1-(butyl-2-alkynol) pyrrolidin-2-yl] imidazo [1, 5-a] pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, in particular to an improved process for the preparation of 4-{8-amino-3-[(2S)-1-(butyl-2-alkynol) pyrrolidin-2-yl] imidazo [1, 5-a] pyrazin-1-yl}-N-( The present invention relates to a large scale process for the manufacture of 4-{8-amino-3-[(2S)-1-(butyl-2-alkynol) pyrrolidin-2-yl] imidazo [1, 5-a] pyrazin-1-yl}-N-(pyridin-2-yl) benzamide, and intermediates employed in such processes.

The invention provides methods for purifying isavuconazonium sulfate comprising the steps of —(a) providing a mixture comprising the sulfate salt of the compound of formula (I) and an aliphatic alcohol, wherein the pH of the mixture is in the range of about pH 1 to about pH 6; —(b) allowing a first portion of the sulfate salt of the compound of formula (I) to crystalize from the mixture; and —(c) adding an aprotic organic solvent to the mixture and allowing an additional portion of the sulfate salt of the compound of formula (I) to precipitate from the mixture.

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

Improved partitioning compositions for froth flotation of mineral ores, and improved methods of froth flotation using the partitioning compositions have been developed. The partitioning compositions are suitably added to a mineral ore slurry in a single addition to provide a sparge composition that is ready for sparging. The use of the partitioning compositions obviates the need to adjust the pH of the ore slurry before or after the addition, and further avoids the use of compounds having a flashpoint of 60 °C or less. Meanwhile, the partitioning compositions obtain improved grade and recovery of phosphate product (P2O5) in froth flotation of phosphate ores, when compared to conventional chemistry and methods used for froth flotation of a phosphate ores.

The invention relates to a method and installation for recycling a mixture comprising at least one fluorinated fluid, the mixture comprising one or more fluorinated chemical components and one or more contaminants selected from one or more hydrocarbons and / or one or more fluorinated contaminants, including a double membrane filtration step to reduce the contaminant content of the mixture. Figure for the abstract: Figure 1

The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

The present disclosure relates to a liquid composition, an adjuvant composition, and a concentrate solute composition. The liquid composition comprises an organic solute, a water- immiscible solvent, an aliphatic water-insoluble alcohol, and optionally water. The adjuvant composition comprises a water-immiscible solvent and an aliphatic water-insoluble alcohol. The concentrate solution composition comprises an organic solute, a water-immiscible solvent, and an aliphatic water-insoluble alcohol. The present disclosure relates to a method for suppressing volatility of organic solutes from their aqueous solutions.

An inhibitor composition is provided for mitigating undesired polymerization in the vapor space during the purification of reactive vinyl monomers. The polymerization inhibitor composition includes at least a first inhibitor compound having a stable nitroxide radical and a second inhibitor comprising a phenylenediamine. Methods of inhibiting polymerization of monomers in a vapor space using the disclosed compositions are also provided.