296results about "Organic compounds purification/separation/stabilisation" patented technology

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

The invention discloses a process and equipment for producing special melamine by a gas phase quenching method. The production process comprises the following steps: hot process gas from an outlet of a melamine reactor is in contact with cold process gas in a crystallizer, a generated solid A is discharged from the bottom of the crystallizer, and mixed gas enters a trap for gas-solid separation to obtain a solid B; the solid A is conveyed into a high-pressure collecting device A through high-pressure conveying gas A, it is ensured that the temperature of the high-pressure conveying gas A is higher than 120 DEG C in the conveying process, after gas-solid separation is conducted in the high-pressure collecting device A, the solid A is conveyed into a packaging device A through low-pressure conveying gas A, and it is ensured that the temperature of the solid A at the conveying tail end does not exceed 85 DEG C.

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

The invention provides a synthesis method of a selective THRbeta agonist key intermediate compound as shown in the formula (II). The synthesis method has the advantages of cheap and easily available raw materials, simple and efficient process, no need of SFC chiral resolution, high yield, controllable quality and cost, and huge industrialization prospect.

Provided are a purification method and purification apparatus that deplete the metal impurities in an organic solvent. This organic solvent purification method is a purification method that depletes the metal impurities in an organic solvent, said organic solvent purification method is characterized by comprising: a filtration step for filtering the organic solvent with a particle removal filter; and an ion-exchange step for passing the organic solvent yielded by the filtration step through an ion exchanger.

The present invention provides an improved process for isolating 2,4-bis-(2,4-dihydroxyphenyl)-6-(4-methoxyphenyl)-1,3,5-triazine (DIOPAT) from an aqueous alkaline mixture M comprising the DIOPAT, 2,4-dihydroxybenzophenone, and aluminum salts, wherein the process comprises the steps of precipitating the DIOPAT by acidifying the mixture M to a pH<1; heating the acidified mixture M to a temperature in the range of from 80° C. to 95° C.; and separating of the precipitated DIOPAT from the dissolved 2,4-dihydroxybenzophenone and the dissolved aluminum salts with a ceramic membrane by means of diafiltration.

The invention provides a method for preparing a storage-resistant water-insoluble isothiazolinone, and belongs to the technical field of chemical synthesis. The invention first uses N,N'-di-n-octyl dithiodipropionamide, a chlorinated solvent and chlorine as raw materials for chlorination reaction to prepare 2-n-octyl isothiazolin-3-ketone OIT and / or 4,5-dichloro-2-n-octyl isothiazolin-3-ketone DCOIT finished products with less impurity content, thereby reducing the discoloration reaction caused by impurities; the product is then mixed with a stabilizer, and the inhibitory effect of the stabilizer on the free radical discoloration process is utilized to finally obtain a storage-resistant water-insoluble isothiazolinone, thereby solving the problem of discoloration of the water-insoluble isothiazolinone during storage.

Inhibitor compositions for abating undesirable emulsion polymerization during processing of hydrocarbon stream laden with reactive vinylic monomers are provided. The polymerization inhibitor compositions include at least a first inhibitor compound having a stable nitroxide radical and a second inhibitor including phenylenediamine. Methods of inhibiting the polymerization of monomers using the compositions of the disclosure are also provided. The methods of inhibiting polymerization of monomers include a step of adding a composition of the disclosure to a process stream. The process stream includes an ethylenically unsaturated monomer that is suspended in the bulk-phase and highly polar solvents as distractive distillation solvents.

The present invention relates to a method for extracting natural bioactive compounds having different polarities from solid plant waste, such as kale waste, by using a solid-liquid extraction-liquid-liquid extraction (SLE-LLE) integrated platform, using a ternary solvent mixture comprising a natural deep eutectic solvent (NADES) comprising glycerol, ethyl acetate and water, or a binary solvent mixture comprising NADES comprising glycerol and ethyl acetate is used. The invention also relates to a solid plant waste extract comprising NADES comprising glycerol, water and one or more polyphenol compounds.

The present invention provides a membrane separation device suitable for suppressing the growth of an undesirable microorganism inside the membrane separation device. The membrane separation device includes: a pervaporation membrane that separates a fermented liquid containing a volatile organic compound into a permeated fluid and a non-permeated fluid; a feed space and a permeation space separated from each other by the pervaporation membrane; a feed space inlet for supplying the fermented liquid to the feed space; and a feed space outlet for discharging the non-permeated fluid from the feed space. The feed space inlet is positioned below the feed space outlet.

The invention discloses nano composite hydrogel modified silica gel as well as a preparation method and application thereof. The method comprises the following steps: (1) preparing carbon nanoparticles; (2) preparing a polyvinyl alcohol aqueous solution and a pre-polymerized solution of carbon nanoparticles and hydrogel; (3) preparation of nano-composite hydrogel modified silica gel: adding the pre-polymerized liquid and silica gel into the polyvinyl alcohol aqueous solution under stirring, adding an initiator, carrying out hot bath, carrying out condensation reflux in an inert atmosphere for reaction, and then adding a polyvinyl alcohol cross-linking agent and an HCl aqueous solution for reaction; and after the reaction is finished, centrifugally washing and drying to obtain the nano-composite hydrogel modified silica gel. The nano-composite hydrogel modified silica gel has excellent hydrophilicity, can be used as a hydrophilic mode liquid chromatography filler, and has great development space and application potential in the field of chromatographic separation and analysis.

An apparatus includes a distillation container configured to receive a mixture. The apparatus includes a column fluidly connected to the distillation container. A mesh is disposed in the column. The apparatus includes a plurality of conduits fluidly connected to respective vacuums. A fractionating head is fluidly connected to the column. The column is fluidly connected between the distillation container and the fractionating head.

A chemical synthesis apparatus comprising: one or more reactors configured to produce a process stream comprising at least one chemical product from one or more reactants; a feed preparation system configured to prepare one or more feed streams comprising one or more of one or more reactants to be introduced into one or more reactors; and / or a product purification system configured to separate at least one chemical product from reaction byproducts, unreacted reactants, or a combination thereof within the process stream, wherein the chemical synthesis apparatus is configured such that a majority of the net energy required for heating, cooling, compression, or a combination thereof used via one or more reactors, feed preparation systems, product purification systems, or a combination thereof is provided by a non-carbon-based energy source, renewable energy source, and / or electrical power.

The invention discloses an in-situ acetylation-co-crystallization method and application of the in-situ acetylation-co-crystallization method in organic molecular structure determination, and the in-situ acetylation-co-crystallization method comprises the following steps: synthesizing a cyclic trinuclear silver (I) complex as a crystallization partner, and carrying out an in-situ acetylation reaction in an organic molecular sample, after the reaction is completed, adding a crystallization partner for co-crystallization; the application of the in-situ acetylation-co-crystallization method in the determination of the organic molecular structure comprises the following steps: preparing a co-crystal from an organic molecule to be detected through the in-situ acetylation-co-crystallization method, collecting crystallographic data of the co-crystal, and analyzing to obtain a crystal structure of an acetylation product of the organic molecule to be detected; and determining the chemical structure and the spatial configuration of the to-be-detected organic molecule according to the crystal structure of the to-be-detected organic molecule acetylation product. The method can be used for structure determination of a series of acetylated organic molecules such as alcohols, phenols, amines and the like.

The present application relates to allulose crystals, which have an X-ray powder diffraction pattern including peaks at 2θ diffraction angles of 18.8±0.5°, 15.2±0.5°, and 19.5±0.5° in X-ray powder diffraction (XRD) analysis, a sweetener composition containing allulose crystals, and a method for producing allulose crystals.

The invention belongs to the field of separation and purification of bio-based chemicals, and particularly relates to a method for directionally separating organic acid in biomass pyrolytic oil and efficiently purifying levoglucosenone. According to the method, pyrolysis oil obtained by selective pyrolysis of biomass is taken as a raw material, firstly, a medium-polarity extraction agent is utilized to perform two-phase step-by-step fractional extraction on the pyrolysis oil, and a water phase rich in organic acid and an oil phase rich in LGO are respectively obtained; and the water phase is sequentially subjected to alkalization, acidification, filtration and water washing treatment to obtain an organic acid solid. And putting the oil phase into a rectifying tower, separating under the conditions that the temperature is # imgabs0 # and the vacuum degree is 300-2000Pa, and removing an extracting agent, furans and oligomers, thereby obtaining the high-purity LGO. The pyrolytic oil is subjected to coupling treatment of two-phase step-by-step fractional extraction, organic acid extraction and rectification, so that the aim of separating and purifying high-added-value chemicals from the low-value and complex-component pyrolytic oil is fulfilled.

The invention belongs to the technical field of biological fermentation, and provides a microbial fermentation efficient extraction process and device, and the process comprises the following steps: step 1) continuous disinfection; the method comprises the steps of (1) fermentation, (2) fermentation culture, (3) cross-tank conveying, (4) temperature control and high-pressure recovery, (5) split-flow extraction and purification and (6) refining and drying, the quality of fermentation liquor is improved through a fermentation process precise control technology and a new fermentation technological process, and the product yield is improved through an efficient extraction technology.

The present invention relates to a process for separating a mixture comprising lactide(s) and glycolide comprising the steps of:p) providing a mixture comprising lactide(s) and glycolide, wherein said mixture is provided in the molten state,q) determining the crystallization point of said mixture,r) determining a desired amount of lactide or of glycolide to be recovered from said mixture,s) selecting a suitable crystallization temperature (Tc) based on the desired amount of lactide or of glycolide to be recovered as determined in step c),t) subjecting said mixture to a melt crystallization at said temperature Tc, thereby obtaining a mother liquid and a crystallized product, wherein said crystallized product comprises crystalized lactide or crystallized glycolide, andu) recovering said crystallized product.The process of the invention may comprise additional step(s) for the further purification of the recovered crystallized product and / or for increasing amounts of recovered crystallized product.

The present disclosure provides a method for recovering an ionic liquid from a mixed liquid containing the ionic liquid and an organic acid.

The present invention provides a method for separating racemic lactide in high yield and high efficiency without the risk of side reactions, even when the ratio of L-lactide is low.

The present invention provides a free radical polymerization inhibitor, its preparation method and use, and a composition comprising hydroxyethyl methacrylate. The free radical polymerization inhibitor has a boiling point of 350°C or higher. The free radical polymerization inhibitor is applied in the extractive distillation separation process of hydroxyethyl methacrylate, and the content of the free radical polymerization inhibitor in the hydroxyethyl methacrylate product taken to the top of the column is very small, which does not adversely affect the color number and downstream application. The free radical polymerization inhibitor is selected from one or more of the following structures:

The present invention provides a method for synthesizing a key intermediate compound represented by formula (II) of a selective THR beta agonist. Raw materials used in the method are inexpensive and readily available, the process is simple and efficient, no SFC chiral separation is required, the yield is high, quality and costs are controllable, and the method has great industrial prospects.

The present invention relates to an improved process for the preparation of crystalline forms of oxaborole derivatives which are used as agents in the treatment of mild-to-moderate atopic dermatitis. The present invention specifically relates to an improved process for the preparation of crystalline forms of Crisaborole (Form II). The present invention specifically relates to an improved process for the preparation of crystalline forms of Crisaborole (Form II) through crisaborole sodium salt. The present invention specifically relates to an improved process for the preparation of highly pure Crisaborole through crisaborole sodium salt.