The invention relates to a pharmaceutical preparation for treating climacteric depression syndrome and an application thereof. The pharmaceutical preparation contains Chinese angelica, radix curcumae, herba eupatorii, cicada slough, radix astragali, liquorice, fructus forsythiae, prepared aconitum carmichaelii, radix acanthopanacis semticosi, Chinese cinquefoil herb, herba lycopi, caulis sinomenii, solidago canadensis, herba lagotis, katsumade galangal seed, cortex fraxini, rhizoma cibotii, dandelion, fructus mume, mulberry, fructus tritici levis, pollen pini, tribulus terrestris seedling, herba patriniae and strobilanthes dyerianus. In the invention, the selected traditional Chinese medicine materials lay emphasis on yin-yang coordination, and the climacteric syndrome is treated by the combined action of the medicines; and toxicity tests indicate that the pharmaceutical preparation provided by the invention has relatively high safety and is suitable for further promotion and application. The matters such as protein extracted from the traditional Chinese medicine materials are easily utilized by a human body to realize good effects of relieving depression and dissipating mass and tranquilizing mind and fixing qi. Moreover, the capsules of the pharmaceutical preparation provided by the invention are easy to operate and suitable for technological mass production.