A media and content distribution system and method are provided, wherein specific media and content, including advertising material, real time traffic, news, sports, weather, and financial stock and/or other like information is delivered via cellular or other wireless network technology to locally distributed display panels, such as large plasma and LCD screens, positioned in high traffic or viewing areas. In addition, an exemplary media and content distribution system can include a highly complex scheduling and rotating capability that enables multiple media files to display at multiple locations based on each individual display requirement for advertising, training, entertainment, and other purposes. An exemplary media and content distribution system comprises a Global Scheduling System (GSS) and a Regional Content Delivery System (RCDS) configured to communicate through a communications network such as the Internet. Content and media can suitably be delivered from the Regional Content Delivery System to a Remote Display Unit (RDU) through cellular or other wireless network. The Remote Display Unit can suitably “poll” the Regional Content Delivery System to receive data and information, and then proceed to store the data and information locally to suitably reduce network utilization.