The present invention discloses methods and apparatus for developing, analyzing, investigating, and advising healthcare and well-being related decisions. In particular, the present invention relates to the architecture of systems in either stand-alone or distributed/collaborative/pervasive settings, the components of the systems and their underlying processes and couplings, the computational techniques built into the methods, input data sources integrated into and output results produced and distributed by the systems, as well as the apparatus for carrying out the corresponding user interaction, data access and collection, data integration and processing, data-driven inferences and simulation, intelligent computations, decision analytics, and decision support to generating solutions to various healthcare analytics and decision-making problems. This invention also relates to two working illustrations of the methods and apparatus that present the embodiment illustrations of the present invention.