The invention discloses a health monitoring system for structures of a great building and a bridge, which comprises sensor terminals, a data acquisition and transmission system, a data processing and control system, a structural health data management system and a structural health condition evaluation system, wherein the data acquisition and transmission system is a distributed measurement system; a plurality of data acquisition sub-stations read data from the corresponding sensor terminals and transmit the data to a field monitoring work station; the data acquisition and transmission system is connected with the data processing and control system through a network; the data processing and control system is connected to the structural health data management system; and the structural health data management system is connected and interacted with the structural health condition evaluation system. The health monitoring system provides an on-line, dynamic and real-time monitoring mode, improves an automated level of structural health monitoring and the reliability, security and generality of the system, provides technical basis for implementation of health monitoring by using a life cycle of the building as a guidance, and provides an advanced and efficient technical measure for structure monitoring of civil engineering.