13 results about "NODAL" patented technology

The invention provides a control node locating protecting method of undercutting channel segment water level lowering amplitude. The method comprises the steps that a lateral erosion zone and a deep erosion zone are divided; a target channel section is subjected to meshing, a plane two-dimension water flow mathematic model is established, parameter calibration and verification are carried out; a protection project is generalized to the plane two-dimension water flow mathematic model, the arranging zone and the width of the protecting project are determined; local gradient amplification and upstream water level amplification corresponding to each working condition are obtained, mesh sequences are analyzed respectively; key nodes or other nodes which have obvious influence are selected, for lateral erosion nodes, a hidden closure dam and a beach protection part are arranged on a river branch or a bottomland, and for deep erosion nodes, a bottom protecting band or a hidden closure dam are placed in a main groove. According to the method, nodes are divided into the lateral erosion nodes and the deep erosion nodes, protection part difference of the nodes in different types is provided, by comparing the efficiency of a local channel segment arranging protecting project, the positions of the nodes are accurately located, and the optimum efficiency of the protecting project is guaranteed powerfully.

This application pertains to the use of Compound (A): or a pharmaceutically acceptable salt thereof, for the treatment of various diseases or disorders, including, for example, advanced non-Hodgkin lymphoma (NHL), relapsed / refractory (R / R) non-Hodgkin lymphoma (NHL), transformed follicular lymphoma, nodal T-follicular helper cell lymphoma (nTFHL), relapsed / refractory (R / R) nodal T-follicular helper cell lymphoma, nodal T-follicular helper cell lymphoma - angioimmunoblastic type (nTFHL- Al) / advanced angioimmunoblastic T-cell lymphoma (AITL), or relapsed / refractory (R / R) nodal T-follicular helper cell lymphoma - angioimmunoblastic type (nTFHL-AI) / angioimmunoblastic T-cell lymphoma (AITL).

The disclosure relates to a cell culture method for deriving a multipotent neuromesodermal progenitor (NMP) cell and / or lineages of specific anterior-posterior positions along the human body axis and / or cell types of matched anterior-posterior position, from a human pluripotent stem cell (PSC), comprising culturing said stem cell under conditions and with reagents modulating the following signalling pathways: (i) activation of FGF signalling for a duration of about 12-120 hours; (ii) activation of WNT signalling for a duration of about 48-120 hours; (iii) inhibition of SMAD signalling, including TGF-beta / activin-Nodal signalling and BMP signalling, for a duration of about 48-120 hours, wherein said progenitor co-expresses SOX2, TBXT, CDX2 and CDX1 at RNA and / or protein level(s).The disclosure further relates to a composition for use in deriving multipotent NMPs and / or daughter lineages of a specific anterior-posterior position in the human body and / or cell types of matched anterior-posterior position from human pluripotent stem cells (PSC), a multipotent NMP, a cervical and a thoracic NMP obtained by culturing human PSCs, a composition for use in generating lumbar level NMPs from the multipotent NMPs, a lumbar level NMP obtained by culturing the multipotent NMP, a composition for use in generating tbx6 expressing presomitic mesoderm cells from the multipotent NMPs, a tbx6 expressing presomitic mesoderm cell obtained by culturing the multipotent NMP, a human cell derived from the multipotent NMP, a cell population, a kit and a cellular composition.

Provided here are methods of treating lymphomas for example, peripheral T-cell lymphomas (PTCLs) (e.g., nodal Tfh cell lymphomas) and / or cutaneous T-cell lymphomas (CTCLs) in a subject, by administering to the subject Compound A, or a pharmaceutically acceptable salt thereof. In some cases, the lymphomas are BCL6 positive. In some cases, the lymphomas are relapsed or refractory. In some cases, the subjects are treatment-naïve (i.e., previously untreated).

This invention relates to the field of finite element stress calculation technology, specifically to an aortic stress calculation system based on finite element analysis. In this invention, multiple sets of aortic displacement vectors and element stress vectors are spliced ​​into a response matrix according to the sequence of nodal degrees of freedom and element numbering. The Gram-Schmidt orthogonalization method is introduced to process the retained vectors, compressing the directional coincident components and linearly correlated components, resulting in stronger stability of the reduced-order basis space and smoother conversion of high-dimensional discrete equations to low-dimensional expressions. The Newton-Raphson algorithm is introduced in the path state update stage, where load step difference, nodal displacement increment, and integral point stress tensor are continuously recorded. The path turning state and load propagation form are adjusted synchronously. Facing high internal pressure, large deformation, and nonlinear response scenarios, peak tracking continuity is stronger, the frequency of solving repeated integral models is reduced, the high-risk area of ​​the aortic wall is more concentrated, and the numerical support for scheme comparison, parameter scanning, and risk pre-assessment is more sufficient.

The present invention belongs to the technical field of stem cells. Provided are a culture medium for induced hypoblast stem cells and the use thereof. Provided is a culture medium for induced hypoblast stem cells. The components of the culture medium comprise platelet-derived growth factor AA, a leukemia inhibitory factor, fibroblast growth factor 4, GSK-3α / β inhibitor CHIR99021, TGF-β type I receptor inhibitor A83-01, and bone morphogenetic protein 4. The culture medium for induced hypoblast stem cells can accurately regulate the activity of key signaling pathways such as NODAL, BMP, WNT, FGF, and JAK / STAT in the process of somatic cell reprogramming, and ensure that the properties of hypoblast stem cells are maintained in the process of somatic cell reprogramming to support the self-renewal and hypoblast lineage induction of somatic cells in the reprogramming process, thereby realizing the fate transition of somatic cells to hypoblast stem cells.

The present disclosure provides a mechanics calculation method and apparatus for a pipeline. The method includes: generating a pipe-beam model formed by connecting a plurality of pipe-beam elements; generating a target shell component mesh model formed by joining a plurality of shell elements; replacing, with the target shell component mesh model, a pipe-beam element at a corresponding position in the pipe-beam model to form a hybrid model; performing finite element calculation on the hybrid model to obtain a displacement of each node of the hybrid model; calculating nodal internal forces of the pipe-beam elements based on nodal displacements of the pipe-beam elements; calculating stresses of the respective shell elements based on mesh nodal displacements of the target shell component mesh model; and calculating stresses of the pipe-beam elements based on the nodal internal forces of the pipe-beam elements.

This invention discloses a method and system for parsing radiological image data, belonging to the field of data analysis technology. The method includes: registering and extracting features from PET metabolic images and ultrasound images to generate physiological metabolic feature vectors; reconstructing the organ surface manifold based on the real parts of compressed composite features, and combining Gaussian curvature detection and vascular continuous homology analysis to obtain manifold feature vectors; constructing a dynamic hypergraph based on the physiological metabolic feature vectors and manifold feature vectors to generate cross-modal fusion feature vectors; inputting the cross-modal fusion feature vectors into a constraint generator to solve the elastic wave equation and generate a diagnostic report; combining the elastic wave equation with a Monte Carlo random perturbation model, quantifying deformation anomalies through finite element nodal displacement fields, and combining morphological-metabolic-topological multi-dimensional parameters to significantly improve the sensitivity of malignant lesion detection.

The present invention relates to the field of biotechnology, specifically to the directed synthesis of reticular pathway products. Compared with the transformation of steroid substrates using natural microbial endogenous pathways, the present invention uses a re-constructed artificial heterologous reticular pathway in a yeast chassis. By rationally combining pathway component proteins, the directed synthesis of nodal products can be achieved. By combinatorial expression of pathway component homologous proteins with different catalytic specificities, the further improvement of pathway conversion efficiency can be realized. At the same time, an artificial pregnenolone synthesis pathway is constructed in a microbial chassis, and by introducing specific downstream androstenedione synthesis pathway components, the directed synthesis of androstenedione pathway nodal compounds is achieved using simple carbon sources as substrates.

The present invention discloses a tetranuclear nodular Zn(II) complex with antitumor activity, its preparation method and application, belonging to the field of pharmaceutical technology. The molecular formula of the tetranuclear nodular Zn(II) complex with antitumor activity is [Zn4 II (C 16 H 12 Br2N8-H)4](ClO4)4·8CH3OH·5H2O, and the ligand is 4,6-bis(6-bromopyridine-2-carbaldehyde)pyrimidine hydrazone. The complex of the present invention has significant inhibitory effects on the proliferation of human breast cancer cells MCF-7 and lung cancer cells A549, and the inhibitory activity is significantly stronger than that of the positive control drug cisplatin, and it has no cytotoxicity to normal cells HL-7702. The inhibitory effect of the complex of the present invention on tumor cells is also stronger than that of using the ligand alone. It shows that the tetranuclear nodular Zn(II) complex with antitumor activity of the present invention has good in vitro antitumor activity and is expected to be developed into an antitumor drug.

To provide a method for efficiently inducing differentiation in vitro of spherical human cell aggregates containing axial mesodermal cells from human pluripotent stem cells, in order to realize the transplant application to patients with degenerative disc disease; and to provide the spherical human cell aggregates containing axial mesodermal cells induced to differentiate in vitro.SOLUTION: A spherical human cell aggregate has the following characteristics: (1) it has two distinct regions, a primitive node area and a non-node area; (2) the primitive node area and the non-node area have a structure consisting of at least two layers; (3) axial mesoderm cells are present in the first layer on the surface of the primitive node area, and endoderm cells are substantially absent in the primitive node area; and (4) endoderm cells are present in the first layer on the surface of the non-node area.SELECTED DRAWING: None

A system for providing navigational guidance for a medical procedure may comprise a processor and a memory operably coupled to the processor for storing instructions that, when executed by the processor, cause the system to perform operations. The operations may comprise receiving an anatomic model of an anatomic region, performing an analysis of the anatomic model to facilitate selection a plurality of nodal sites for analysis, generating a procedure sequence for the plurality of nodal sites, providing navigational guidance to direct a medical instrument to a nodal site of the plurality of nodal sites in the procedure sequence, and gathering local image data from the medical instrument at the nodal site.

The present invention relates to a method for evaluating nodal lesions by magnetic resonance imaging using a contrast agent comprising biofunctionalized magnetic nanoparticles with an iron core coated on the outside with a polymer and conjugated to an antibody specific for the tumor type being evaluated. Images generated from magnetic resonance imaging using the contrast agent show heterogeneous hypointensity or heterogeneous architecture in areas where antibody binding is present.