8 results about "NODAL" patented technology

The invention provides a control node locating protecting method of undercutting channel segment water level lowering amplitude. The method comprises the steps that a lateral erosion zone and a deep erosion zone are divided; a target channel section is subjected to meshing, a plane two-dimension water flow mathematic model is established, parameter calibration and verification are carried out; a protection project is generalized to the plane two-dimension water flow mathematic model, the arranging zone and the width of the protecting project are determined; local gradient amplification and upstream water level amplification corresponding to each working condition are obtained, mesh sequences are analyzed respectively; key nodes or other nodes which have obvious influence are selected, for lateral erosion nodes, a hidden closure dam and a beach protection part are arranged on a river branch or a bottomland, and for deep erosion nodes, a bottom protecting band or a hidden closure dam are placed in a main groove. According to the method, nodes are divided into the lateral erosion nodes and the deep erosion nodes, protection part difference of the nodes in different types is provided, by comparing the efficiency of a local channel segment arranging protecting project, the positions of the nodes are accurately located, and the optimum efficiency of the protecting project is guaranteed powerfully.

Provided here are methods of treating lymphomas for example, peripheral T-cell lymphomas (PTCLs) (e.g., nodal Tfh cell lymphomas) and / or cutaneous T-cell lymphomas (CTCLs) in a subject, by administering to the subject Compound A, or a pharmaceutically acceptable salt thereof. In some cases, the lymphomas are BCL6 positive. In some cases, the lymphomas are relapsed or refractory. In some cases, the subjects are treatment-naïve (i.e., previously untreated).

This invention relates to the field of finite element stress calculation technology, specifically to an aortic stress calculation system based on finite element analysis. In this invention, multiple sets of aortic displacement vectors and element stress vectors are spliced ​​into a response matrix according to the sequence of nodal degrees of freedom and element numbering. The Gram-Schmidt orthogonalization method is introduced to process the retained vectors, compressing the directional coincident components and linearly correlated components, resulting in stronger stability of the reduced-order basis space and smoother conversion of high-dimensional discrete equations to low-dimensional expressions. The Newton-Raphson algorithm is introduced in the path state update stage, where load step difference, nodal displacement increment, and integral point stress tensor are continuously recorded. The path turning state and load propagation form are adjusted synchronously. Facing high internal pressure, large deformation, and nonlinear response scenarios, peak tracking continuity is stronger, the frequency of solving repeated integral models is reduced, the high-risk area of ​​the aortic wall is more concentrated, and the numerical support for scheme comparison, parameter scanning, and risk pre-assessment is more sufficient.

The present invention belongs to the technical field of stem cells. Provided are a culture medium for induced hypoblast stem cells and the use thereof. Provided is a culture medium for induced hypoblast stem cells. The components of the culture medium comprise platelet-derived growth factor AA, a leukemia inhibitory factor, fibroblast growth factor 4, GSK-3α / β inhibitor CHIR99021, TGF-β type I receptor inhibitor A83-01, and bone morphogenetic protein 4. The culture medium for induced hypoblast stem cells can accurately regulate the activity of key signaling pathways such as NODAL, BMP, WNT, FGF, and JAK / STAT in the process of somatic cell reprogramming, and ensure that the properties of hypoblast stem cells are maintained in the process of somatic cell reprogramming to support the self-renewal and hypoblast lineage induction of somatic cells in the reprogramming process, thereby realizing the fate transition of somatic cells to hypoblast stem cells.

The present disclosure provides a mechanics calculation method and apparatus for a pipeline. The method includes: generating a pipe-beam model formed by connecting a plurality of pipe-beam elements; generating a target shell component mesh model formed by joining a plurality of shell elements; replacing, with the target shell component mesh model, a pipe-beam element at a corresponding position in the pipe-beam model to form a hybrid model; performing finite element calculation on the hybrid model to obtain a displacement of each node of the hybrid model; calculating nodal internal forces of the pipe-beam elements based on nodal displacements of the pipe-beam elements; calculating stresses of the respective shell elements based on mesh nodal displacements of the target shell component mesh model; and calculating stresses of the pipe-beam elements based on the nodal internal forces of the pipe-beam elements.

This invention discloses a method and system for parsing radiological image data, belonging to the field of data analysis technology. The method includes: registering and extracting features from PET metabolic images and ultrasound images to generate physiological metabolic feature vectors; reconstructing the organ surface manifold based on the real parts of compressed composite features, and combining Gaussian curvature detection and vascular continuous homology analysis to obtain manifold feature vectors; constructing a dynamic hypergraph based on the physiological metabolic feature vectors and manifold feature vectors to generate cross-modal fusion feature vectors; inputting the cross-modal fusion feature vectors into a constraint generator to solve the elastic wave equation and generate a diagnostic report; combining the elastic wave equation with a Monte Carlo random perturbation model, quantifying deformation anomalies through finite element nodal displacement fields, and combining morphological-metabolic-topological multi-dimensional parameters to significantly improve the sensitivity of malignant lesion detection.

To provide a method for efficiently inducing differentiation in vitro of spherical human cell aggregates containing axial mesodermal cells from human pluripotent stem cells, in order to realize the transplant application to patients with degenerative disc disease; and to provide the spherical human cell aggregates containing axial mesodermal cells induced to differentiate in vitro.SOLUTION: A spherical human cell aggregate has the following characteristics: (1) it has two distinct regions, a primitive node area and a non-node area; (2) the primitive node area and the non-node area have a structure consisting of at least two layers; (3) axial mesoderm cells are present in the first layer on the surface of the primitive node area, and endoderm cells are substantially absent in the primitive node area; and (4) endoderm cells are present in the first layer on the surface of the non-node area.SELECTED DRAWING: None

The present invention relates to a method for evaluating nodal lesions by magnetic resonance imaging using a contrast agent comprising biofunctionalized magnetic nanoparticles with an iron core coated on the outside with a polymer and conjugated to an antibody specific for the tumor type being evaluated. Images generated from magnetic resonance imaging using the contrast agent show heterogeneous hypointensity or heterogeneous architecture in areas where antibody binding is present.