714 results about "Magnetic nanoparticles" patented technology

The invention relates to a double-color magnetic nanoparticle imaging method based on a single-harmonic system matrix, which comprises the following steps: respectively moving two different types of magnetic nanoparticle samples to a central zero magnetic field point, applying a scanning magnetic field to enable the zero magnetic field point to scan the whole imaging field of view, applying an excitation magnetic field to magnetize magnetic nanoparticles, and applying an excitation magnetic field to magnetize the magnetic nanoparticles; acquiring magnetization frequency spectrum signals of the two magnetic nanoparticle samples; the method comprises the following steps: constructing single harmonic system matrixes A1 and A2 based on single harmonic of magnetization spectrum signals of two kinds of magnetic nanoparticle samples; measuring a to-be-measured object formed by the two kinds of magnetic nanoparticles to obtain a measurement magnetization signal U; transversely splicing the single harmonic system matrixes A1 and A2 of the two different types of magnetic nanoparticles to obtain a new single harmonic system matrix A; the concentration distributions c1 and c2 of two different types of magnetic nanoparticles are obtained by combining a new single-harmonic system matrix A with a measurement magnetization signal U, and the concentration distributions of the two different types of magnetic nanoparticles are respectively sent into different color channels to be displayed in different colors. The method has important significance in promoting the application of the magnetic nanoparticle imaging technology in clinical medicine.

The invention relates to a kitchen waste oil recovery treatment method, which comprises: S1, carrying out multi-field synergistic pretreatment: sequentially carrying out ultrasonic wave and high-frequency pulse electric field treatment on waste oil to break an emulsion layer, adding magnetic nanoparticles to adsorb polar impurities, and carrying out magnetic field separation to obtain high-purity oil; s2, supercritical catalytic reaction: under the CO2 supercritical condition, using a core-shell structure composite catalyst to synchronously perform transesterification reaction and glycerol dehydration reaction; s3, dynamic membrane separation: separating biodiesel and glycerol in real time through an intelligent membrane assembly; s4, gradient utilization of energy: recovering reaction waste heat to drive membrane distillation to concentrate wastewater, and using tail gas CO2 for carbonation reaction to generate calcium carbonate. Through four core technologies of multi-field collaborative pretreatment, low-temperature supercritical catalysis, dynamic membrane separation and energy gradient utilization, triple limitations on efficiency, cost and environmental protection in the prior art are remarkably broken through.

The invention relates to the technical field of material preparation, and discloses a magnetic basalt fiber reinforced wear-resistant self-lubricating coating and a preparation method thereof, and a coating and a preparation method thereof, and the preparation method comprises the following steps: step 1, treating short-cut basalt fibers with an acid and / or alkali solution, mixing with an iron salt solution to obtain a reaction solution, carrying out hydrothermal reaction to obtain the magnetic basalt fiber loaded by the magnetic nanoparticles; step 2, adding a filler into the resin matrix solution, dispersing, and grinding to obtain resin slurry; and 3, adding the magnetic basalt fiber in the step 1 into the resin slurry in the step 2, adding a curing agent, and uniformly mixing to obtain the required coating. According to the method, the contact behavior and the abrasion mechanism of a friction pair are optimized, the friction coefficient and the abrasion rate are reduced, the tribological performance of the obtained coating is improved, the service life of a mechanical kinematic pair is prolonged, and the reliability and the stability of equipment operation are improved.

The invention provides an easy-to-scale efficient biological magnetic separation system and method and application. The magnetic separation method comprises the following steps: marking a target object in a to-be-detected suspension by adopting magnetic nanoparticles, and putting the marked to-be-detected suspension into a separation container; a modularized magnet array is arranged in the separation container, the modularized magnet array is composed of permanent magnets, and the permanent magnets are assembled into the cuboid modularized magnet array; the surface of the permanent magnet is coated with a polytetrafluoroethylene coating; the modularized magnet array moves in the suspension under the control of a driving magnet arranged outside the separation container to generate a dynamic gradient magnetic field, and a target object is captured by the modularized magnet array under the action of the gradient force of the magnetic field; removing the liquid in the separation container; adding the resuspension into a separation container, and recovering a target object by physical ultrasonic washing; or adding a chemical dissociation solution into the separation container to recover the target object.

The invention belongs to the technical field of microbiological detection, and discloses a composite probe for detecting salmonella enteritidis and a preparation method. The composite probe for detecting the salmonella enteritidis comprises magnetic nanoparticles FeO, wherein the surface of the magnetic nanoparticles FeO is modified with an aptamer apt which is specifically combined with the salmonella enteritidis; the surface of the long afterglow nano particle PLNPs is modified with a DNA (Deoxyribose Nucleic Acid) sequence cDNA (Complementary Deoxyribonucleic Acid) complementary with the aptamer; the aptamer apt and the complementary DNA sequence cDNA are subjected to hybridization to form a composite probe structure FeO-SEapt (at) PLNPs-cDNA (complementary deoxyribonucleic acid). The long afterglow luminescence characteristic of PLNPs (ZnGaO: Cr) is utilized, and an excitation light source is stopped before detection, so that signal acquisition completely avoids autofluorescence of a sample matrix, background fluorescence interference is thoroughly eliminated, and the signal-to-noise ratio is remarkably improved.

The invention discloses a coating, a preparation method and application, and relates to the technical field of anticorrosive coatings. A dry film of the coating comprises 0.1 wt%-6wt% of a lamellar filler; the lamellar filler is prepared by loading magnetic nanoparticles on the surfaces of two-dimensional nanoparticles and coating a layer of high-molecular polymer. After the coating forms a film, a specific magnetic control orientation curing method is matched, so that high dispersion stability and planar orientation arrangement of the two-dimensional nano filler in a resin matrix are realized, and corrosion of water and oxygen to a base material can be effectively blocked. When the thickness of the coating dry film is only 1-2 microns, the coating dry film still has no obvious corrosion phenomenon after being subjected to a neutral salt spray test for 2000 hours. The metal base material with the thin coating thickness has heat conductivity, corrosion resistance and weather resistance, the preparation process is simple, the cost is low, and the metal base material has extremely high market application value.

According to the high-temperature-resistant nitrogen-fixing bacteria microcapsule fertilizer and the preparation method thereof, aiming at the problems of thallus inactivation and nutrient loss in a high-temperature environment, a sodium alginate-chitosan double-layer embedding technology is combined with magnetic nanoparticle modification, and a stable double-layer structure is formed by optimizing the ratio of an embedding material, so that the high-temperature-resistant nitrogen-fixing bacteria microcapsule fertilizer is prepared. The survival rate and activity of the nitrogen-fixing bacteria at high temperature are remarkably improved, and meanwhile, the functions of intelligent nutrient release and magnetic recovery are achieved. The fertilizer is prepared from composite microcapsules, amino acid, humic acid and other raw materials according to a specific ratio through magnetic field orientation treatment, multi-stage mixing, atomization granulation and magnetic field screening processes, the particle size is controlled to be 0.5-3.35 mm, and the shelf life is prolonged to 12 months. The method has the technical effects that trehalose-glycerol / sorbitol synergistically forms a glassy protective film to maintain the stability of thalli, gamma-aminobutyric acid activates nitrogenase gene expression, magnetic nanoparticles construct a photosynthetic symbiotic system to optimize rhizosphere oxygen supply, and silanized FeO nanoparticles fix heavy metal ions through electrostatic adsorption, so that the heavy metal ions in the thalli are effectively adsorbed, and the heavy metal ions in the thalli are effectively adsorbed. And the humic acid buffers the pH fluctuation of the soil, so that the nitrogen fixation efficiency is finally improved by 30-50%, and the crop yield is increased by 15-25%.

The invention belongs to the field of adsorption materials, and discloses a porous lignin fiber adsorption material and a production process thereof, the porous lignin fiber adsorption material comprises the following raw materials by weight: 40-60 parts of lignin fiber, 20-30 parts of bamboo fiber, 5-15 parts of chitosan, 5-10 parts of sodium bicarbonate, 5-10 parts of attapulgite, 5-10 parts of zeolite, and 2-5 parts of magnetic nanoparticles; the invention aims to provide the production process of the porous lignin fiber adsorption material, the problems that the existing lignin fiber adsorption material is poor in pore structure, limited in adsorption performance, difficult to separate and the like are solved through an innovative raw material formula and an optimized production process, efficient adsorption of light components in asphalt is realized, the stability of an asphalt mixture is enhanced, and the service life of the asphalt mixture is prolonged. Meanwhile, heavy metal ions, organic pollutants and the like are efficiently adsorbed and rapidly separated, the production energy consumption is reduced, and the environmental protection property and economical efficiency of the process are improved.

A magnetic nanoparticle composite microcapsule, and a preparation method therefor and the use thereof. The preparation method comprises: diluting concentrated ammonia water with absolute ethanol in which nano-Fe3O4 is dispersed, stirring same and adding ethyl orthosilicate, centrifuging same, and then performing washing to obtain Fe3O4 / SiO2 particles; dispersing same in anhydrous ethanol, then adding isopropanol containing tetrabutyl titanate, and performing a treatment to obtain Fe3O4 / SiO2 / TiO2 nanoparticles; adding polyurethane TDI prepolymer to the Fe3O4 / SiO2 / TiO2 nanoparticles, adding same to a core material, then dripping an emulsifier, and stirring same to obtain a core material emulsion; and heating same in a water bath, dropwise adding butanediol, and performing heating, stirring and vacuum filtration to obtain a magnetic nanoparticle composite microcapsule. By means of the loading with a core material having a repair function, the prepared magnetic microcapsule can actively repair damage to an insulating material caused by electrical and mechanical stress, thereby improving the reliability of a device.

The invention discloses a magnetic nanoparticle concentration distribution inversion method and a related device, and relates to the technical field of biomedical engineering.The method comprises the steps that firstly, magnetic nanoparticles in biological tissue are excited through an external magnetic field to generate infinitesimal displacement; and then ultrasonic equipment is adopted to collect ultrasonic ultrafast plane wave imaging data and carry out axial vibration displacement detection, axial vibration displacement actual measurement data and corresponding discrete space and time coordinates are input into the inversion model for iterative inversion, and a magnetic nanoparticle concentration distribution inversion result is obtained. A loss function of the inversion model includes a data-driven loss item and a physical information-driven loss item (based on a Navie equation). Compared with the prior art, the method has the advantages that the physical information neural network is introduced, control equations such as a nano-dimension equation and the like are encoded to the full-connection neural network, physical equations do not need to be excessively simplified, complex and time-consuming modeling for an experimental environment is not needed to obtain simulation data, and higher accuracy and stability are achieved.

The invention relates to the field of demulsifiers, in particular to an oil sludge demulsifier as well as a preparation method and application thereof. The oil sludge demulsifier comprises the following components in parts by mass: 20-35 parts of a surface active compound, 7-12 parts of a sodium alkyl sulfate cosolvent, 0.6-1.8 parts of a stabilizer and 48-55 parts of water, wherein the surface active compound comprises hyperbranched polyamidoamine and polyether amine modified magnetic nanoparticles. According to the oil sludge demulsifier, the problems that most of existing demulsifiers are small in dehydration amount, low in dehydration speed, poor in demulsification effect and low in treated oil content are solved, the demulsification performance of the oil sludge demulsifier is improved, the demulsification and dehydration efficiency is improved, and effective separation of oil sludge is achieved.

The invention provides eye protection liquid for improving eye microcirculation and a preparation method thereof, and belongs to the technical field of medical configuration products. The composition comprises the following components: surface-modified magnetic nanoparticles, a calendula extract, a fermented dogwood extract, xanthophyll, taurine, sodium hyaluronate, hydrolyzed sodium hyaluronate, soya bean lecithin, borneol and fermented vegetable oil. The efficiency of active ingredients is improved through a double-fermentation technology, magnetic targeting and multi-channel compounding are combined, and the preparation method has remarkable advantages in the field of improving periorbital microcirculation. The traditional Chinese medicine composition has an obvious relieving effect on asthenopia and dry skin around eyes; the components of the eye microcirculation eye protection liquid are mild, and adverse reactions such as allergy cannot be caused.

This disclosure relates to magnetic microgel beads, and in particular to magnetic microgel beads for biofunctionalization and methods of making and uses thereof, for example, in biosensing assays. In an embodiment, a magnetic microparticle comprising a magnetic nanoparticle encapsulated by a polymer hydrogel. In another embodiment, an assay for detecting the presence of a target analyte in a sample comprising a) the magnetic microparticle disclosed herein, wherein the biorecognition agent further comprises a reporter moiety; b) an electrochemical chip comprising a working electrode, a counter electrode and a reference electrode; and c) a capture probe functionalized on the working electrode; wherein binding of the biorecognition agent to the target analyte results in production of an electrochemical, electroluminescent or photoelectrochemical signal.

A method and apparatus for preparing tissue of interest in a patient for possible excision by surgery. In one embodiment, the method comprises the steps of: removing a biopsy sample from the tissue of interest; placing a magnetic marker at the biopsy site; performing a pathology analysis of the biopsy sample; and if the pathology analysis indicates that the tissue of interest should be removed, locating the tissue for surgery using a magnetic detection probe. In one embodiment, the marker comprises magnetic nanoparticles in a bioabsorbable matrix. A system for preparing tissue of interest in a patient for possible excision by surgery. In one embodiment, the system includes a magnetic marker and magnetic detection probe system.

The invention provides a Brown relaxation dominated magnetic nanoparticle nonlinear biological information parameter estimation method. The method comprises the following steps: putting a container of a magnetic nanoparticle sample into a to-be-detected object area; applying low and medium frequency alternating current magnetic field excitation to the magnetic nanoparticle sample; collecting magnetization response information of the magnetic nanoparticle sample in real time and extracting harmonic amplitude information from the magnetization response information; carrying out series expansion on the Fokker-Planck equation by using a disturbance expansion method, and deducing a harmonic analytical expression under the Brown relaxation condition; respectively establishing a corresponding temperature estimation model and a hydrodynamic diameter estimation model on the basis of the harmonic analytical expression; respectively substituting the measured harmonic amplitude information into a temperature estimation model or a hydrodynamic diameter estimation model based on a harmonic analytical expression; and respectively solving an equation set formed by the temperature estimation model or the hydrodynamic diameter estimation model to obtain temperature information or hydrodynamic diameter information. According to the invention, the measurement precision and the time resolution of the magnetic nanometer temperature measurement and biomarker identification tool can be improved.

The invention relates to the technical field of synthesis of chemical products, in particular to a synthesis method of acryloyloxyethyl trimethyl ammonium chloride. According to the method, a one-pot reaction system is adopted, ethyl acrylate and N, N-dimethylaminoethanol are taken as raw materials and are subjected to quaternization reaction with chloromethane under an alkaline condition, and efficient conversion is realized through the synergistic effect of a composite catalytic system and a polymerization inhibitor. The composite catalyst is constructed by compounding magnetic nanoparticles and a metal organic framework material, forms a multilevel structure through titanate crosslinking, and has high catalytic activity and magnetic separation and recovery characteristics. The method simplifies the traditional step-by-step process, has the advantages of simple and convenient one-pot operation, recyclable catalyst, high raw material utilization rate, environmental friendliness and the like, and is suitable for large-scale preparation of acryloyloxyethyl trimethyl ammonium chloride.

The invention relates to the technical field of composite materials and 3D printing, in particular to a carbon nanotube composite fiber with magnetic nanoparticles attached to the surface, a preparation method and application. The carbon nano tube and the magnetic nano particle composite fiber are mixed and further mixed with the SiC powder, so that the novel composite material with high strength, high conductivity and good thermal stability is formed, and the novel composite material also has the magnetic responsiveness of the magnetic nano particles and the wear-resistant and corrosion-resistant characteristics of the SiC powder. The composite fiber reinforced SiC material is formed through the 3D printing technology, higher strength, elasticity modulus, design flexibility and magnetic responsiveness can be obtained, hollowed-out, complex and special-shaped structures can be prepared, performance is good, and the composite fiber reinforced SiC material is more suitable for special purposes such as aviation, medicine and military affairs.

The invention discloses a sewage treatment method based on reinforcement of composite magnetic nanoparticles, and belongs to the technical field of sewage treatment, and the sewage treatment method comprises the following steps: 1, pretreatment: intercepting large-particle-size floating objects in wastewater by using a grid, and stirring by using an adjusting tank to uniformly mix water; in the second step, composite magnetic nanoparticles are added into the pretreated wastewater, and nitrogen and phosphorus adsorption and electric energy collection and storage are achieved at the same time; 3, separation: separating the composite particles through a magnetic separation device, and further purifying the wastewater through a sedimentation tank; 4, regeneration: forming an electric field by utilizing the collected electric energy, desorbing particles by combining with a neutral solution of an antibiotic degradation product, and recycling after cleaning; 5, standard reaching and energy consumption balance are carried out, the wastewater is disinfected, the water quality is monitored, the stirring speed and the power supply proportion are adjusted in a linkage mode, and standard emission and energy consumption self-balance are ensured. The method does not need to depend on microorganisms, particles and energy recycling, the treatment efficiency is high, and the operation cost is low.

According to the high-temperature-resistant tracking master batch provided by the invention, a composite structure is adopted, and the matrix layer is composed of the high-temperature-resistant engineering plastic and the inorganic reinforcing agent and has high temperature resistance and mechanical strength; the functional layer is a tracking unit dispersed in the matrix layer and comprises magnetic nanoparticles and a rare earth fluorescent material, and the interface bonding strength is improved through silanization treatment; the protective layer is a microcapsule formed by coating the tracking unit through a sol-gel method, the thermal expansion coefficient difference between the protective layer and the matrix is less than or equal to 10%, and the rupture rate during melt blending at 320 DEG C is less than or equal to 2%. The preparation method of the tracking master batch comprises the steps of high-temperature extrusion and water-cooling pelletizing. The fluorescence intensity attenuation rate of the tracking master batch is smaller than or equal to 5% at the temperature of 300 DEG C, and the tracking master batch is suitable for full-life-cycle tracking of engineering plastics.

The application belongs to the technical field of biology and specifically relates to a method for analyzing glycans on single extracellular vesicles in a fluid sample. The method uses magnetic nanoparticles to capture and manipulate EVs, based on the specific affinity of lectins for specific glycan structures, uses polydisperse microdroplets to separate the captured EVs, realizes local signal amplification in the droplets through enzymatic reaction, adopts fluorescence microscopy to collect images of the droplets, and thus realizes identification and analysis of the glycan components on single EVs. The preparation process of the microdroplets formed by the oscillating emulsification method of the application makes the entire detection process more simple and fast, does not require any microfluidic chip and special device, and can be completed in a centrifugal tube, and all the microdroplets are generated in parallel and quickly, and the amount of microdroplets can be flexibly expanded. Moreover, compared with the traditional ELISA, the method has high sensitivity, low detection limit and small sample consumption.

The invention discloses a soil particle directional deposition sample preparation method based on magnetic / electric field regulation and control, which comprises the following steps: mixing soil particles with a functional medium which is a magnetic nanoparticle dispersion liquid or a charged surfactant solution; enabling the surfaces of the soil particles to adsorb a functional medium through ultrasound or stirring to form temporarily magnetized or charged modified particles; injecting the modified particle suspension into a deposition tank, applying a magnetic field or an electric field, and regulating the long axis direction of the modified particles to a target angle; capturing a particle deposition image in real time through a monitoring system, processing the particle deposition image and calculating a particle deposition direction by utilizing an intelligent image analysis module, and feeding back and adjusting parameters of a magnetic field or an electric field according to a processing result of the intelligent image analysis module; and after deposition is completed, removing the external field to obtain the sample with the controllable deposition angle. The method can be used for accurately preparing soil particle directional deposition samples with different deposition angles, and is simple and convenient to operate and good in repeatability.

A membrane technology based on a wettability material has the problem of membrane pollution and cannot efficiently and stably separate and purify oil-containing wastewater, so that a preparation method of a hydrophilic membrane with excellent hydrophilicity and an open pore channel is urgently needed. The invention discloses an ultrahigh hydrophilic membrane for efficiently and stably separating an oil-in-water emulsion, which is characterized in that magnetic nanoparticles (Fe3O4 MNPs) are wrapped in membrane fibers through electrostatic spinning and an in-situ growth method, and a hydrophilic polyaniline rough micro-nanosphere structure grows on the surface of the membrane fibers. Under the action of a magnetic field, the magnetic particles obtain magnetism, the generated magnetic interaction force pulls the nanofiber to optimize the membrane structure, and hydrophilic groups are further exposed while membrane holes are supported. The flux of the prepared three-dimensional hydrophilic membrane for separating n-hexane-in-water emulsion under the action of a 0.2 T magnetic field is up to 8957.9 Lm <-2 > h <-1 >, and the efficiency is up to 99.87%. The membrane shows optimal separation performance in short-term and long-term cycle tests, and is expected to be applied to actual oily wastewater purification scenes.

The invention belongs to the technical field of biological detection, and particularly relates to a bisulfite-free detection kit for specific site 5-methylcytosine and a detection method thereof. According to the method, a TAPbeta treatment method is adopted, 5hmC is sealed through beta-GT, 5mC oxidation is carried out through TET, and 5mC is reduced into dihydrouracil (DHU) through pyridine borane, so that the apparent difference between 5mC and C and 5hmC is converted into single nucleotide polymorphism difference. In addition, a flow microsphere technology based on PNA-assisted click chemical connection starting is established to detect DNA methylation specific sites. A PNA clip is innovatively introduced into click chemical connection, and non-specific connection is inhibited. Target sequence enrichment, signal amplification and signal acquisition are carried out through surface-functionalized magnetic nanoparticles, and the detection sensitivity is improved to fM. The invention provides a new tool for high-specificity and high-sensitivity epigenetic marker detection.

The invention relates to the technical field of electromagnetic shielding materials, and particularly discloses an electromagnetic shielding composite material with active and passive infrared stealth functions and a preparation method thereof. The composite material comprises an electromagnetic wave reflecting layer and a plurality of electromagnetic wave absorbing layers. The electromagnetic wave reflecting layer is made of silver-plated bacterial cellulose, and efficient reflection of electromagnetic waves is achieved through high conductivity of the silver-plated bacterial cellulose. The electromagnetic wave absorbing layer is formed by compounding bacterial cellulose, multi-walled carbon nanotubes and core-shell magnetic nanoparticles, and the content of the multi-walled carbon nanotubes is gradually decreased and the content of the core-shell magnetic nanoparticles is gradually increased from the position close to the electromagnetic wave reflecting layer to the outside, so that a gradient structure is formed; the gradient design can improve surface impedance matching, promote electromagnetic waves to enter the material, and enhance electromagnetic loss through an interlayer multiple reflection-absorption process. The material disclosed by the invention has the functions of efficient electromagnetic shielding and active and passive infrared stealth.

The invention relates to the technical field of burn and scald treatment, in particular to an intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release. The dressing comprises a core-shell microsphere drug loading system used for realizing physical segmentation of a functional area; the dual-release system is used for realizing surface adsorption of quick-release drug nanoparticles and internal wrapping of sustained-release microspheres; a hydrogel matrix for forming a nanofiber network; and the magnetic control regulator is magnetic nanoparticles dispersed in the hydrogel matrix, and regulates the aperture of the hydrogel network through the action of an external magnetic field. According to the intelligent hydrogel dressing for targeted regulation and control of Mongolian medicine release, the Mongolian medicine compound intelligent hydrogel dressing is developed on the basis of a TRIZ innovative method; through a core-shell microsphere drug loading system and a dual release design, high drug loading capacity and accurate drug release control are synchronously realized.

The invention provides a pretreatment method for detecting various vitamins in food, and relates to the technical field of vitamin detection. Comprising the following steps: a) mixing a food sample with a sodium acetate buffer solution according to a volume ratio of 1: (1-5), adding a combined enzyme for enzymolysis to obtain enzymatic hydrolysate, and collecting filtrate after filtering a membrane; the combined enzyme comprises neutral protease and lipase; the mass volume ratio of the combined enzyme to the sodium acetate buffer solution is 24-32%; b) adding a mixed solvent of normal hexane and acetonitrile into the filtrate, carrying out vortex mixing, centrifuging, and separating to obtain an upper-layer normal hexane phase or a lower-layer acetonitrile phase; and c) transferring the upper-layer normal hexane phase or the lower-layer acetonitrile phase, adding silanized magnetic nanoparticles, oscillating and adsorbing for 15-20 minutes, and removing the silanized magnetic nanoparticles to obtain a sample to be detected. The pretreatment method disclosed by the invention can meet the requirements of detecting various vitamins in different foods, and is high in detection accuracy and precision.

The invention relates to the technical field of sensing of magnetic nano photoelectric materials, in particular to a responsive microsphere based on a three-dimensional magnetic photonic crystal and a preparation method and application thereof, and the responsive microsphere is formed by arranging polyhydroxy compound modified magnetic nanoparticles in a spherical polymer into a non-close packing face-centered cubic or body-centered cubic structure. The responsive microsphere based on the three-dimensional magnetic photonic crystal is easy in color distinguishing, has no angle dependence, does not need to depend on a fluorescent dye or a radioactive label, can realize real-time and in-situ monitoring through own optical characteristics, breaks through the bottlenecks of sensitivity and resolution of a traditional sensor, realizes visual detection, simplifies the detection process, and is suitable for mass production. The cost is reduced. According to the responsive microsphere based on the three-dimensional magnetic photonic crystal, the substance diffusion path is shortened through the small size of the responsive microsphere, and the response speed is remarkably increased in combination with the high specific surface area.

The present application belongs to the field of magnetic nanoparticle measurement, and particularly relates to a high-sensitivity magnetic nanoparticle spectrometer and a waveform signal conversion method thereof, and aims to solve the problem that the dynamic magnetic characteristics of low-concentration magnetic nanoparticles cannot be quantitatively evaluated in the prior art. The present application comprises a driving module, a switching module, a current sampling module, a band-pass filtering module, a rectifying module, a current control module, a voltage adjustment module, a coil matching module, a coil assembly, a receiving coil signal processing module, a signal acquisition analog block, and a main control calculation module. According to the target current demand, the coil matching module can be flexibly edited, and further, the control signal for driving the coil can be automatically generated according to the matched driving circuit and the target waveform, wherein the data acquisition-processing link can restore the waveform and obtain the original spectrum of the magnetic particles through the built-in calculation steps. At the same time, the current compensation loop contained in the present application can compensate the current error caused by factors such as coil temperature rise, parameter drift of the matching module, and change of the on-resistance of the switching module, so as to ensure the constant output of the target harmonic current.

The application discloses a kind of based on magnetic resonance spectrum half-width's magnetic nano particle mass concentration calculation method, belong to magnetic nano material testing technical field, the application with magnetic nano particle induces local magnetic field inhomogeneity and causes magnetic resonance spectrum to produce change as medium, the relationship between the mass concentration of magnetic nano particle and magnetic resonance spectrum half-width is established, since the saturation magnetization intensity of single magnetic nano particle is fixed, so the change of the mass concentration of magnetic nano particle is essentially the change of the number of magnetic nano particle, mass concentration and magnetic resonance spectrum half-width have linear relationship, the change of magnetic nano particle mass concentration can be reflected by measuring magnetic resonance spectrum half-width, realize the measurement of magnetic nano particle mass concentration.

The invention relates to a method and system for detecting cells of a first cell type (1) in a biopsy sample in which a plurality of cells of different cell types (2, 3) are present. The invention further relates to a device for carrying out a magnetic field measurement on cells of a biopsy sample that are labeled with magnetic nanoparticles. The method comprises the following method steps: carrying out tissue dissociation of the biopsy sample in order to singulate the cells present in the biopsy sample; supplying magnetic nanoparticles (11) to the singulated cells in order to selectively label the cells of the first cell type (1); removing the excess magnetic nanoparticles (11); introducing the cells into a microchannel (5), the microchannel (5) having a cross section which allows only one labeled cell (1) to pass through at a time; carrying out a magnetic field measurement in the microchannel (5) by means of a quantum magnetic field sensor (6) based on the F-center principle; and sorting out the labeled cells (1) after they have passed through the microchannel (5).