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2928 results about "Magnetic nanoparticles" patented technology
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Magnetic nanoparticles are a class of nanoparticle that can be manipulated using magnetic fields. Such particles commonly consist of two components, a magnetic material, often iron, nickel and cobalt, and a chemical component that has functionality. While nanoparticles are smaller than 1 micrometer in diameter (typically 1–100 nanometers), the larger microbeads are 0.5–500 micrometer in diameter. Magnetic nanoparticle clusters that are composed of a number of individual magnetic nanoparticles are known as magnetic nanobeads with a diameter of 50–200 nanometers. Magnetic nanoparticle clusters are a basis for their further magnetic assembly into magnetic nanochains. The magnetic nanoparticles have been the focus of much research recently because they possess attractive properties which could see potential use in catalysis including nanomaterial-based catalysts, biomedicine and tissue specific targeting, magnetically tunable colloidal photonic crystals, microfluidics, magnetic resonance imaging, magnetic particle imaging, data storage, environmental remediation, nanofluids,, optical filters, defect sensor , magnetic cooling and cation sensors.
Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
InactiveUS20050130167A1Strong specificityHigh sensitivityMaterial nanotechnologyPowder deliveryFluorescenceBiocompatible coating
The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.
Owner:GEORGIA TECH RES CORP +1
Assembly of arrays on chips segmented from wafers
InactiveUS20050244850A1Bioreactor/fermenter combinationsSequential/parallel process reactionsMagnetite NanoparticlesAnalyte molecule
The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and / or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
Owner:HUANG HIU +1
Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
InactiveUS7459145B2Efficient internalizationHigh sensitivityBiocideMaterial nanotechnologyFluorescenceBiocompatible coating
The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.
Owner:GEORGIA TECH RES CORP +1
Alignment of carbon nanotubes using magnetic particles
InactiveUS20050239948A1Material nanotechnologyLiquid separation by electricityMagnetite NanoparticlesNanometre
Methods are provided for aligning carbon nanotubes and for making a composite material comprising aligned carbon nanotubes. The method for aligning carbon nanotubes comprises adsorbing magnetic nanoparticles to carbon nanotubes dispersed in a fluid medium to form a magnetic particle-carbon nanotube composite in the fluid medium; and exposing the composite to a magnetic field effective to align the nanotubes in the fluid medium. The method for making a composite material comprising aligned carbon nanotubes comprises (1) adsorbing magnetic nanoparticles to carbon nanotubes to form a magnetic particle-carbon nanotube composite; (2) dispersing the magnetic particle-carbon nanotube composite in a fluid matrix material to form a mixture; (3) exposing the mixture to a magnetic field effective to align the nanotubes in the mixture; and (4) solidifying the fluid matrix material to form a nanotube / matrix material composite comprising the aligned nanotubes which remain aligned in the absence of said magnetic field.
Owner:FLORIDA STATE RES FOUND +1
Magnetic nanoparticles
InactiveUS20060233712A1Simple and versatileEasy to mergePowder deliveryBiocideMagnetite NanoparticlesMaterials science
Materials and methods for making small magnetic particles, e.g. clusters of metal atoms, which can be employed as a substrate for immobilising a plurality of ligands. Also disclosed are uses of these magnetic nanoparticles as therapeutic and diagnostic reagents, and in the study of ligand-mediated interactions.
Owner:CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) +1
Magnetically-responsive microspheres
InactiveUS6773812B2Easy to doNanomagnetismSynthetic resin layered productsMicrosphereMagnetite Nanoparticles
Microspheres are constructed using magnetic particles. Hybrid microspheres are constructed using fluorescent or luminescent microspheres and magnetic nanoparticles. Reactive moieties on the surface of the resultant particles can be used for attachment of biologically active molecules, thus allowing selective separations and analytical assays to be performed. Distinguishable subsets of microspheres can be constructed based on fluorescent intensities, and separations can be affected based on variable degree of magnetic content.
Owner:LUMINEX
Magnetic nanoparticle composition and methods for using the same
InactiveUS20070264199A1High drug loadingGood dispersionPowder deliveryNanomedicineMagnetite NanoparticlesFatty acid
The present invention is a magnetic nanoparticle composition with enhanced drug delivery characteristics. The magnetic nanoparticle composition is composed of a magnetic particle core surrounded by a fatty acid and surfactant corona. Methods for increasing the efficacy of therapeutic agents and facilitating diagnostic imaging are also provided.
Owner:BOARD OF RGT UNIV OF NEBRASKA
NMR device for detection of analytes
ActiveUS20070116602A1Add waterHigh sensitivityMaterial analysis by electric/magnetic meansAnalysis using nuclear magnetic resonanceTarget analysisPoint of care
This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and / or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.
Owner:T2 BIOSYST
Magnetic nanoparticle compositions, and methods related thereto
InactiveUS20050271745A1Improve homogeneityHigh metal contentAntibacterial agentsPowder deliveryMagnetite NanoparticlesEngineering
Disclosed are biocompatible magnetic nanoparticle compositions for various therapeutic or biological applications, and methods related thereto. Specifically, the present invention pertains to magnetic nanoparticle compositions prepared via high-pressure homogenization processes that include a turbulent flow zone. The methods of production may involve a two-step or a one-step process. The disclosed magnetic nanoparticle compositions may be useful in the treatment of the body, body part, tissue, cell, or body fluid of a subject for a variety of indications. The disclosed magnetic nanoparticle compositions may also be useful in the fixation, separation, transportation, marking or coding of targets, or energy transformation processes.
Owner:NANOTX INC +1
Magneto-motive ultrasound detection of magnetic nanoparticles
Provided herein are systems, methods and compositions for the use of ultrasound for detection of cells and nanoparticles.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Magnetic nanoscale particle compositions, and therapeutic methods related thereto
InactiveUS20060142749A1Minimal invasionShort course of treatmentAntibacterial agentsPowder deliveryDiseaseMagnetite Nanoparticles
Disclosed are thermotherapeutic compositions for treating disease material, and methods of targeted therapy utilizing such compositions. These compositions comprise a) stable single domain magnetic particles; b) magnetic nanoparticles comprising aggregates of superparamagnetic grains; or c) magnetic nanoparticles comprising aggregates of stable single magnetic domain crystals and superparamagnetic grains. These compositions may also comprise a radio isotope, potential radioactive isotope, chemotherapeutic agent. These methods comprise the administration to a patient's body, body part, body fluid, or tissue of bioprobes (energy susceptive materials attached to a target-specific ligand), and the application of energy to the bioprobes so as to destroy, rupture, or inactivate the target in the patient. Energy forms, such as AMF, are utilized to provide the energy. The disclosed methods may be useful in the treatment of a variety of indications, including cancers, diseases of the immune system, central nervous system and vascular system, and pathogen-borne diseases.
Owner:ASPEN MEDISYS +1
Thermotherapy via targeted delivery of nanoscale magnetic particles
InactiveUS7074175B2Minimal invasionShort course of treatmentNanotechElectrotherapyBiocompatible coatingMagnetite Nanoparticles
Disclosed are compositions comprising magnetic nanoparticles, a biocompatible coating, and a target-specific ligand. Also disclosed are devices for treating diseased tissue for use with such compositions. Further disclosed are methods for treating diseased tissue, such as cancer, using such compositions and devices, as well as methods for treating diseased tissue utilizing hypertermia.
Owner:ASPEN MEDISYS +1
NMR device for detection of analytes
ActiveUS20090134869A1Add waterHigh sensitivityAnalysis using nuclear magnetic resonanceElectric/magnetic detectionTarget analysisPoint of care
This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and / or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.
Owner:T2 BIOSYST
Nanoparticle tracer-based electrochemical DNA sensor for detection of pathogens-amplification by a universal nano-tracer (AUNT)
InactiveUS20110171749A1Rapid and sensitive detectionRapid and sensitive and valid identificationMaterial nanotechnologyNanomedicineSalmonella entericaEscherichia coli
The present invention relates to methods and compositions for identifying a pathogen. The inventions provide an antibody-based biosensor probe comprising (AUNT) in combination with a polymer-coated magnetic nanoparticle. In particular, a nanoparticle-based biosensor was developed for detection of Escherichia coli O157:H7 bacterium in food products. Further described are biosensors for detecting pathogens at low concentrations in samples. Even further, a gold nanoparticle-based electrochemical biosensor detection and amplification method for identifying the insertion element gene of Salmonella enterica Serovar Enteritidis is described. The present invention provides compositions and methods for providing a handheld potentiostat system for detecting pathogens outside of the laboratory. The AUNT biosensor system has applications detecting pathogens in food, water, beverages, clinical samples, and environmental samples.
Owner:BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIV
Biological detector and method
ActiveUS20080204022A1Low costCompact assemblyNanosensorsAnalysis using nuclear magnetic resonanceProximateSpectroscopy
A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is / are present in the fluid.
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC +2
Process of forming magnetic nanocomposites via nanoparticle self-assembly
InactiveUS6972046B2Inhibition of agglomerationNanomagnetismTransportation and packagingMagnetite NanoparticlesSolvent
A process of forming a hard-soft phase, exchange-coupled, magnetic nanocomposite includes forming a dispersion of magnetic nanoparticles, separating the magnetic nanoparticles from a solvent of the dispersion so as to allow self-assembly of the magnetic nanoparticles, and removing a coating from the nanoparticles, which are disposed in a self-assembled, locally-ordered nanostructure.
Owner:IBM CORP +1
Composite magnetic nanoparticle drug delivery system
ActiveUS20120265001A1Accurate placementLimit deliveryBiocideHeavy metal active ingredientsDiseaseOil emulsion
A composite magnetic nanoparticle drug delivery system provides targeted controlled release chemotherapies for cancerous tumors and inflammatory diseases. The magnetic nanoparticle includes a biocompatible and biodegradable polymer, a magnetic nanoparticle, the biological targeting agent human serum albumin, and a therapeutic pharmaceutical composition. The composite nanoparticles are prepared by oil-in-oil emulsion / solvent evaporation and high shear mixing. An externally applied magnetic field draws the magnetic nanoparticles to affected areas. The biological targeting agent draws the nanoparticles into the affected tissues. Polymer degradation provides controlled time release delivery of the pharmaceutical agent.
Owner:WICHITA STATE UNIVERSITY
Carbon Coated Magnetic Nanoparticles and Their Use in Separation Processes
ActiveUS20100059449A1Improve mobilityRapidity and efficiencyNanomagnetismLiquid separation by electricityMagnetic field gradientMagnetite Nanoparticles
The invention relates to a process for separating a dispersed phase from a continuous phase comprising the steps of i) contacting said phases with an effective amount of nanoparticles; ii) applying a magnetic field gradient to the obtained system; iii) separating the obtained phases wherein said nanoparticles are of the core shell type, said core consists of a metal or alloy having soft magnetic properties and said shell contains a graphene layers which are optionally functionalized; to new nanoparticles and method of manufacturing such nanoparticles.
Owner:ETH ZZURICH
Anisotropic nanoparticle amplification of magnetic resonance signals
InactiveUS7202667B2Magnetic property measurementsMaterial analysis by using resonanceMagnetic anisotropyMagnetite Nanoparticles
Owner:CALIFORNIA INST OF TECH
Magnetic nanoparticles, bulk nanocomposite magnets, and production thereof
Provided herein are systems, methods, and compositions for magnetic nanoparticles and bulk nanocomposite magnets.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Functionalized Magnetic Nanoparticles and Methods of Use Thereof
The present invention provides functionalized magnetic nanoparticles comprising a functional group, which functionalized magnetic nanoparticles exhibit differential binding to a tissue, indulging brain tissue, bone, and vascular tissues. The present invention further provides compositions, including pharmaceutical compostions, comprising a subject functionalized magnetic nanoparticle. The present invention further provides diagnostic and research methods including use of subject functionized magnetic nanoparticles. The present invention further provides a magnetic resonance imaging (MRI)-visible drug delivery system; drugs using MRI, as well as tissue-specific drug delivery.
Owner:RGT UNIV OF CALIFORNIA
Magnetic composite nano microsphere capable of emitting fluorescence and preparation thereof
The invention discloses a magnetic composite nano microsphere capable of emitting fluorescent light and a preparation method thereof, which belong to the inorganic nanophase material field. The preparation method comprises the following steps: firstly, the sol-gel method or the reversed phase microemulsion method is adopted for performing base catalysis on alkyl silicate, and a layer of silicon dioxide is uniformly coated on the surface of inorganic magnetic nano particles; secondly, an amino silane coupling agent is adopted for performing surface finish on silicone dioxide; thirdly, semiconductor quantum dots are absorbed on the surface of the silicone dioxide through the electrostatic action between an amino group and a carboxyl group on the surface of the amino silane coupling agent; and fourthly, the magnetic composite nano microsphere with a core-shell structure capable of emitting the fluorescent light is obtained. The preparation method has easy obtained raw materials and low cost. The composite nano microsphere obtained has good stability, controllable grain size, narrow distribution, and has good magnetic responsivity and performance of being capable of emitting the fluorescent light, and the two performances are controllable. The magnetic composite nano microsphere and the preparation method can be applied in the fields of biomedicine, bioengineering, etc. including immunoassay, biological labeling and separation, cell imaging and so on.
Owner:TONGJI UNIV
Separation system and efficient capture of contaminants using magnetic nanoparticles
InactiveUS20070114181A1Efficient capture rateShort operating timeMaterial nanotechnologySedimentation separationMagnetite NanoparticlesBiology
Methods are disclosed for the capture, detection, separation, isolation and quantification of contaminants in a starting material. Also disclosed are competitive assay methods for the detection and quantification of contaminants in a starting material. Kits for use with the method are disclosed as well. A system for capturing, separating and / or concentrating contaminants from a material is also presented. The system captures, separates and / or concentrates contaminants such as bacteria, viruses, other microorganisms, and / or larger items, such as insects, from a variety of materials, such as food, and environmental and clinical materials. In general, the system uses a rotating magnetic field to mix the material with magnetic particles to capture the target contaminants, and a fixed magnetic field to separate and concentrate the captured target contaminants.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ARKANSAS
Magnetic nanoparticle therapies
Various compositions, methods, and devices are provided that use fluorescent nanoparticles, which can function as markers, indicators, and light sources. The fluorescent nanoparticles can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one embodiment, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and / or illuminate an area surrounding the tissue. In another embodiment, the fluorescent nanoparticles can be used on a device or implant to locate the device or implant in the body, indicate an orientation of the device or implant, and / or illuminate an area surrounding the device or implant. The fluorescent nanoparticles can also be used to provide a therapeutic effect.
Owner:ETHICON ENDO SURGERY INC
Separation system and efficient capture of contaminants using magnetic nanoparticles
InactiveUS7699979B2Rapid diagnosisImproved prognosisMaterial nanotechnologySedimentation separationMagnetite NanoparticlesNanometre
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ARKANSAS
Elastomeric magnetic nanocomposite biomedical devices
InactiveUS20050267321A1Low flexural modulusIncrease stiffnessElectrotherapyMedical devicesMuscle tissueElastomer
A biomedical device of a smart elastomer, more particularly relating to a class of low modulus elastomers with dispersed, aligned magnetic nanoparticles therein that allow for controlling the flexural modulus of the device and engaged tissue in response to an applied magnetic field. An exemplary embodiment is used for treating obstructive airway syndrome wherein one or more implants including an elastomer magnetic nanocomposite are placed in a patient's soft palate. During sleep, a source of magnetic flux is applied to stiffen the implants to dampen vibrations in tissue which occur in snoring and sleep apnea episodes. The magnetic flux is provided by a permanent magnet or by a magnetic field source coupled to a controller for modulating the stiffness of the implant(s). In similar embodiments, the controlled modulus implants can be used to treat various anatomic structures such as upper airway tissue, oral cavity tissue, gastrointestinal tract tissue, urinary tract tissue, cardiovascular tissue, muscle tissue, penile tissue, sphincters and skin.
Owner:SHADDUCK JOHN H
Nanoparticle loaded stem cells and their use in MRI guided hyperthermia
InactiveUS20120283503A1Enhanced MR propertyEnough timeElectrotherapyMedical devicesMri guidedMagnetite Nanoparticles
The present invention provides stem cells loaded with bi-functional magnetic nanoparticles (nanoparticle-loaded stem cells (NLSC)) that both: a) heat in an alternating magnetic field (AMF); and b) provide MRI contrast enhancement for MR-guided hyperthermia. The nanoparticles in the NLSC are non-toxic, and do not alter stem cell proliferation and differentiation, the nanoparticles do however, become heated in an alternating magnetic field, enabling therapeutic applications for cancer treatment. NLSC can deliver hyperthermia to hypoxic areas in tumors for sensitization of those areas to subsequent treatment, thus delivering therapy to the most treatment-resistant tumor regions. The heating of diseased tissue either results in direct cell killing or makes the tumor more susceptible to radio- and / or chemotherapy. The NLSC of the present invention can be used for MR image-guided hyperthermia in oncology, in stem cell research for cell tracking and heating, and for elimination of mis-injected stem cells.
Owner:OSTROVSKA LYUBOV PHD
Nanoparticle-doped porous bead and fabrication method thereof
InactiveUS20100224831A1Improved photo-stabilityIncreased durabilityBleaching apparatusElectrostatic spraying apparatusMetal oxide nanoparticlesPhotoluminescence
Disclosed are a nanoparticle-doped porous bead with a highly enhanced photoluminescence without wavelength shift and improved durability, and a fabrication method thereof, the nanoparticle-doped porous bead comprising porous beads, and nanoparticles radially bonded onto homocentric spheres of the porous beads by an electrostatic attractive force, the homocentric sphere located inside the porous bead near a surface thereof, wherein the nanoparticles are photoluminescent nanoparticles or mixed nanoparticles of photoluminescent nanoparticles and another nanoparticles, wherein the another nanoparticle is one or more than two mixed, selected from a group consisting of magnetic nanoparticle, metallic nanoparticle and metal oxide nanoparticle.
Owner:KOREA INST OF SCI & TECH
Core-shell magnetic nanoparticles and nanocomposite materials formed therefrom
InactiveUS7029514B1Eliminate needSuitably producedMaterial nanotechnologyNanomagnetismSynthesis methodsMagnetite Nanoparticles
Owner:UNIVERSITY OF ROCHESTER
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