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211 results about "Biological objects" patented technology
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The essence of the method of biodialysis (hemodialysis with biological object) developed and suggested by the authors for clinical use consists in that the healthy organism exerts, through a system of mass transfer, a therapeutic action on the sick organism.
Systems and methods for phase measurements
InactiveUS20050057756A1Efficient collectionNo loss of precisionOptical measurementsPhase-affecting property measurementsCellular componentPhase noise
Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and / or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
Owner:MASSACHUSETTS INST OF TECH
Systems and methods for phase measurements
InactiveUS20050105097A1Efficient collectionNo loss of precisionOptical measurementsInterferometersCellular componentPhase noise
Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and / or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
Owner:MASSACHUSETTS INST OF TECH
System and method for optoacoustic imaging
InactiveUS20070015992A1Scattering properties measurementsDiagnostics using tomographyPulse shaperElectromagnetic radiation
A system and method are described for optoacoustic imaging a structural or compositional characteristic of an biological object using a coherent, broad range frequency tunable, electromagnetic radiation source and a pulse shaper to generate a sequence of electromagnetic radiation excitation signals.
Owner:GENERAL ELECTRIC CO
Method for obtaining a picture of the internal structure of an object using x-ray radiation and device for the implementation thereof
InactiveUS6754304B1Improve accuracyReduce usageX-ray spectral distribution measurementHandling using diffraction/refraction/reflectionX-rayX ray dose
Owner:KUMAKHOV MURADIN ABUBEKIROVICH
Systems and methods for phase measurements
InactiveUS7365858B2No loss of precisionReduce coherenceOptical measurementsInterferometersCellular componentPhase noise
Owner:MASSACHUSETTS INST OF TECH
Method for determining a path along a biological object with a lumen
ActiveUS20070024617A1Shorten the timeAvoid excessive computationImage enhancementImage analysisData setVoxel
A path between specified start and end voxels along a biological object with a lumen, such as a vessel, within a patient image three-dimensional volume data set comprising an array of voxels of varying value is identified using an algorithm that works outwards from the start voxel to identify paths of low cost via intermediate voxels. The intermediate voxels are queued for further expansion of the path using a priority function comprising the sum of the cost of the path already found from the start voxel to the intermediate voxel and the Euclidean distance from the intermediate voxel to the end voxel. A cost function that depends on the voxel density is used to bias the algorithm towards paths inside the object. The number of iterations of the voxel required to find a path from the start to the end voxel, and hence the time taken, can be significantly reduced by scaling the Euclidean distance by a constant. Usefully, the constant is greater than 1, such as between 1.5 and 2.
Owner:TOSHIBA MEDICAL VISUALIZATION SYST EURO
3D imaging of live cells with ultraviolet radiation
InactiveUS20090208072A1Reconstruction from projectionMaterial analysis by optical meansOptical tomographyFluence
A method for 3D imaging of cells in an optical tomography system includes moving a biological object relatively to a microscope objective to present varying angles of view. The biological object is illuminated with radiation having a spectral bandwidth limited to wavelengths between 150 nm and 390 nm. Radiation transmitted through the biological object and the microscope objective is sensed with a camera from a plurality of differing view angles. A plurality of pseudoprojections of the biological object from the sensed radiation is formed and the plurality of pseudoprojections is reconstructed to form a 3D image of the cell.
Owner:VISIONGATE
Biological detector and method
ActiveUS20080204022A1Low costCompact assemblyNanosensorsAnalysis using nuclear magnetic resonanceProximateSpectroscopy
A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is / are present in the fluid.
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC +2
Method for navigating a virtual camera along a biological object with a lumen
ActiveUS20070052724A1Shorten the lengthEasy to viewSurgeryCharacter and pattern recognitionData setVirtual camera
A method of navigating along a biological object with a lumen represented by a three-dimensional volume data set comprises generating a plurality of navigation segments connectable in a sequence, each segment having a start point within the lumen, a direction and a length. The navigation may be used for a camera in a virtual endoscopic examination, for example. The direction of each segment is determined by casting groups of rays outwards from the start point of the segment to the object wall, and calculating an average ray length for each group. The group having the largest average ray length is selected, and the axial direction of this group is used as the direction for the segment. The average ray lengths of the groups may be weighted using the direction of the previous segments to bias the navigation generally forward, or may be weighted using a view direction of the camera to allow a user to turn the camera into a chosen branch in the object.
Owner:TOSHIBA MEDICAL VISUALIZATION SYST EURO
Method and apparatus for determining conditions of a biological tissue
InactiveUS20050283091A1Preventing heart failureAvoid failureDiagnostic recording/measuringSensorsIntermediate frequencyCell membrane
In one method, one or more excitation signals with the same or different frequencies are applied to a biological object such as a tissue, simultaneously or consequently. Response signals are then cross-correlated with delayed excitation signals. Cross-correlation products are then auto-correlated. Cross-correlation products correspond to conditions of the tissue and auto-correlation product corresponds to changes in the conditions. Measuring electrical characteristics at low, intermediate and high frequency is also disclosed. At low frequency, the current flows mostly through the extracellular liquid of tissue. At high frequency, the current passes through the cell membranes freely enough to dominate the overall impedance. At both frequencies, the delay is less than 1 / 30 of the period of the respective signal. The intermediate frequency between the low frequency and the high frequency carries information about quick changes in the condition of the tissue. The delay in one example is from about 1 / 30 to ¼ of the period of the intermediate signal.
Owner:TALLINN UNIVERSITY OF TECHNOLOGY
Integrated organ-on-chip systems and applications of the same
ActiveUS20140356849A1Maintain performanceBiochemistry apparatusDead animal preservationMicrofluidicsEngineering
In one aspect of the invention, an integrated bio-object microfluidics chip includes a fluidic network having a plurality of inlets for providing a plurality of fluids, a plurality of outlets, a bio-object chamber for accommodating at least one bio-object, a plurality of fluidic switches, and one or more pumps, coupled to each other such that at least one fluidic switch operably and selectively receives one fluid from a corresponding inlet and routes the received fluid, through the one or more pumps, to the bio-object chamber so as to perfuse the at least one bio-object therein, and one of the downstream fluidic switches selectively delivers an effluent of the at least one bio-object responsive to the perfusion to a predetermined outlet destination, or to the at least one fluidic switch for recirculation.
Owner:VANDERBILT UNIV
Endoscope apparatus
The endoscope apparatus includes a wavelength switching unit for switching emission wavelengths of a first illumination light including at least broadband light and a second illumination light including only plural kinds of narrowband light, an imaging unit for capturing an image of a subject by the first illumination light or the second illumination light having the switched emission wavelength in each imaging frame, an acquisition unit for acquiring biological information relating to form and / or function of a biological object serving as the subject and a mode switching unit for switching at least two diagnosis modes based on the biological information. The number of imaging frames by the imaging unit in which the emission wavelengths of the first and second illumination light are switched varies depending on the diagnosis mode.
Owner:FUJIFILM CORP
Systems and methods for phase measurements
InactiveUS7557929B2No loss of precisionReduce coherenceOptical measurementsInterferometersCellular componentPhase noise
Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and / or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
Owner:MASSACHUSETTS INST OF TECH
Reflex Longitudinal Imaging Using Through Sensor Insonification
An ultrasonic reflex imaging device and a method are described. A device according to the invention may include a platen, a generator, and a receiver positioned between the platen and the generator. A backer may be positioned so that the insonification device is between the receiver array and the backer. The backer may be configured to absorb or delay energy that originated from the generator. The generator produces an energy pulse, which travels through the receiver and the platen to reach a biological object. Part of the energy pulse is reflected from the biological object. The reflected energy pulse travels through the platen to the detector. The detector converts the reflect energy pulse to electric signals, which are then interpreted to create an image of the biological object.
Owner:QUALCOMM INC
Biological detector and method
InactiveUS20080315875A1Low costReduced cost and maintenance and space requirementMagnetic property measurementsNanosensorsMagnetite NanoparticlesSpectroscopy
Owner:SILLERUD LAUREL O
System, method, and kit for processing a magnified image of biological material to identify components of a biological object
ActiveUS20080144895A1Enhance the imageImage enhancementImage analysisComputer visionBiological materials
A system, method and kit for processing an original image of biological material to identify certain components of a biological object by locating the biological object in the image, enhancing the image by sharpening components of interest in the object, and applying a contour-finding function to the enhanced image to create a contour mask. The contour mask may be processed to yield a segmented image divided by structural units of the biological material.
Owner:VALA SCI
Method and arrangement for robust interferometry
ActiveUS20120307258A1Expand the measurement rangeIncrease in coherence lengthInterferometersUsing optical meansLight beamElectromagnetic radiation
An arrangement and a method are provided for robust interferometry for detecting distance, depth, profile, form, undulation, flatness deviation and / or roughness or the optical path length in or on technical or biological objects, including in layered form, or else for optical coherence tomography (OCT), with a source of electromagnetic radiation and with an interferometer, in particular also in the form of an interference microscope, having an object beam path and having a reference beam path, in which an end reflector is arranged, and a line-scan detector for detecting electromagnetic radiation in the form of at least one spatial interferogram.
Owner:UNIV STUTTGART
Graphene-based gas and bio sensor with high sensitivity and selectivity
ActiveUS20140260547A1Material analysis by electric/magnetic meansNanosensorsDielectric substrateComputational physics
A graphene sensor and method for selective sensing of vapors, gases and biological agents are disclosed. The graphene sensor can include a substrate; a dielectric substrate on an upper layer of the substrate; a layer of graphene on an upper layer of the dielectric substrate; and a source and drain contact on an upper surface of the layer of graphene. The method for detection of vapors, gases and biological objects with low frequency input as a sensing parameter can include exposing a graphene device to at least one vapor, gas, and / or biological object, the graphene device comprising: a substrate; a dielectric substrate on an upper layer of the substrate, a layer of graphene on an upper layer of the dielectric substrate, and a source and drain contact on an upper surface of the layer of graphene; and measuring a change in a noise spectra of the graphene device.
Owner:RGT UNIV OF CALIFORNIA
System and method for measuring phase
Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and / or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
Owner:MASSACHUSETTS INST OF TECH
System, method, and kit for processing a magnified image of biological material to identify components of a biological object
Owner:VALA SCI
Method of examining biological, biochemical, and chemical characteristics of a medium and apparatus for its embodiment
InactiveUS6628376B1High sensitivityWide dynamic rangeSamplingScattering properties measurementsImage resolutionOrder form
Examinations of biological, biochemical, and chemical characteristics of media, mainly of biologic origin, or media that are in contact with biological objects whose living is influenced by the media characteristics. One excites surface plasmon polaritons on a metal layer covered with a material sensitive to the examined characteristics of a medium, produces an interference with a beam of radiation reflected under these conditions and a reference beam, records parameters of a spatial intensity distribution in the resulting interference pattern, and judges the examined characteristics on the basis of the recorded parameters. The proposed method and apparatus ensure the technical result that consists in upgrading of sensitivity and resolution of measurements, at least, by two orders.
Owner:NIKITIN PETR IVANOVICH
Functional imaging of cells with optical projection tomography
ActiveUS20120105600A1Well formedReconstruction from projectionScattering properties measurementsOptical projection tomographyOptical tomography
A method for 3D imaging of a biologic object (1) in an optical tomography system where a subcellular structure of a biological object (1) is labeled by introducing at least one nanoparticle-biomarker. The labeled biological object (1) is moved relatively to a microscope objective (62) to present varying angles of view and the labeled biological object (1) is illuminated with radiation having wavelengths between 150 nm and 900 nm. Radiation transmitted through the labeled biological object (1) and the microscope objective (62) within at least one wavelength bands is sensed with a color camera, or with a set of at least four monochrome cameras. A plurality of cross-sectional images of the biological object (1) from the sensed radiation is formed and reconstructed to make a 3D image of the labeled biological object (1).
Owner:VISIONGATE
Method and apparatus for characterizing biological objects
InactiveUS20130171685A1Simple and fast and accurate characterizationBioreactor/fermenter combinationsBiological substance pretreatmentsElectricityRadio frequency
In order to quantitatively characterize biological objects, for example individual cells, a stimulus is applied to a biological object in a contactless fashion. A measurement and a further measurement are performed on the biological object in order to ascertain a response of the biological object to the stimulus, wherein the measurement and the further measurement comprise detecting Raman scattering on and / or in the biological object and / or capturing data using digital holographic microinterferometry (DHMI). The biological object is characterized according to a result of the measurement and is sorted if needed. The stimulus can be applied by means of a laser beam that creates optical tweezers or an optical trap, by means of ultrasonic waves or an electric or magnetic radio frequency field.
Owner:CELLTOOL GMBH
Method and apparatus for noninvasive determination of the absolute value of intracranial pressure
ActiveUS7147605B2Easy to useSafe and reliableDiagnostics using pressurePerson identificationBiological bodyEngineering
A device for obtaining an indication of the intracranial pressure of a living body includes a positional sensor which determines an initial position of an elastic biological object when the intracranial pressure within the living body is zero and which determines a subsequent position of the elastic biological object when the intracranial pressure within the living body is unknown but greater than zero. A pressure generator applies an external pressure to the elastic biological object, and a comparator compares the initial position with the subsequent position so as to identify the unknown intracranial pressure of the living body as that external pressure which causes the subsequent position to be equal to the initial position.
Owner:SCIENCEFORBRAIN UAB +1
Method for determining a path along a biological object with a lumen
ActiveUS7379062B2Shorten the timeAvoid excessive computationImage enhancementImage analysisData setVoxel
A path between specified start and end voxels along a biological object with a lumen, such as a vessel, within a patient image three-dimensional volume data set comprising an array of voxels of varying value is identified using an algorithm that works outwards from the start voxel to identify paths of low cost via intermediate voxels. The intermediate voxels are queued for further expansion of the path using a priority function comprising the sum of the cost of the path already found from the start voxel to the intermediate voxel and the Euclidean distance from the intermediate voxel to the end voxel. A cost function that depends on the voxel density is used to bias the algorithm towards paths inside the object. The number of iterations of the voxel required to find a path from the start to the end voxel, and hence the time taken, can be significantly reduced by scaling the Euclidean distance by a constant. Usefully, the constant is greater than 1, such as between 1.5 and 2.
Owner:TOSHIBA MEDICAL VISUALIZATION SYST EURO
Endoscope apparatus
The endoscope apparatus includes an illumination unit for irradiating at least three kinds of illumination light having different wavelengths including standard light, first and second reference light onto a biological object, a switching unit for periodically switching the illumination light, an imaging unit for capturing image data by the illumination light in each imaging frame, and an acquisition unit for acquiring biological function information from the captured image data. The irradiation order of illumination light is switched at least in order of the first reference light, the standard light and the second reference light, a standard image by the standard light and reference images by the reference light are acquired, and the biological function information is calculated based on the standard image and the reference images.
Owner:FUJIFILM CORP
Method for producing the image of the internal structure of an object with X-rays and a device for its embodiment
InactiveUS20050031078A1Improve accuracyReduce usageHandling using diffraction/refraction/reflectionHandling using diaphragms/collimetersFluorescenceX-ray
Inventions related to the intra-vision means, designed for production of visually sensed images of the internal structure of an object, in particular, of a biological object, are aimed at higher accuracy of determining the relative density indices of the object's substance in the obtained image together with avoiding complex and expensive engineering; when used for diagnostic purposes in medicine, the dosage of tissues surrounding those that are examined is decreased. X-rays from source 1 is concentrated (for example, using X-ray lens 2) in the zone that includes the current point 4, to which the measurement results are attributed and which is located within the target area 7 of the object 5. Excited in this zone secondary scattered radiation (Compton, fluorescent) is transported (for example, using X-ray lens 3) to one or more detectors 6. By moving the said zone, the target area 7 of object 5 is scanned, and based upon population of the intensity values of the secondary radiation, which are obtained with the help of one or more detectors 6 and which are determined concurrently with coordinates of the current point 6, judgment on the density of the object's substance in this point is made. Density values together with respective coordinate values obtained using sensors 11 are used in the means 12 for data processing and imaging to build up a picture of substance density distribution in the target area of the object.
Owner:KUMAKHOV MURADIN ABUBEKIROVICH
Method for infrared imaging of living or non-living objects including terrains that are either natural or manmade
An improved system for infrared (IR) imaging of terrain is disclosed wherein or or more IR cameras may be used at one or more locations to record images at multiple focal planes. The images are all taken of the same field of view but at varied focal planes. Global Positioning Satellite (GPS) may be used to track each camera location and each camera captures images of the object. Information regarding the orientation of the camera may also be measured. The digital information from the images from each camera at varying focal planes, the distance from the object to each camera, orientation of camera and the GPS location of each camera is transferred to a computer where the data is processed through the use of merging and photogrammetry software utilizing appropriate algorithms to convert the multiple images into a two-dimensional or three-dimensional image with improved depth of field.
Owner:NORTHROP GRUMMAN SYST CORP
Method and device for producing biomass of photosynthesizing microorganisms/phototrophical algae and biomass of these microorganisms pigments
InactiveUS20090035835A1Bioreactor/fermenter combinationsBiological substance pretreatmentsBiofuelExcretion process
The invention relates to biotechnology, in particular to methods and means of physical action on biological structures of photosynthesing microorganisms, phototrophic algae in particular. The invention can be used in pharmaceutical, cosmetic and foodstuff industries, as well as for obtaining biofuel from algae In the process of the method implementation radiation of cultivated solution of photosynthesizing microorganisms / phototrophical algae is carried out by the action of electromagnetic waves of mm range and low intensity. Stimulation of increasing photosynthesizing microorganisms / phototrophical algae biomass and biomass of their pigments (excretions) is obtained with industrial production as a result of the resonance effect which is caused by the interaction of electromagnetic wave and biological cell. Irradiation of cultivated solution of photosynthesizing microorganisms / phototrophical algae is performed by electromagnetic waves of mm range and low intensity at different phases of cultured biological objects development.
Owner:SLAVIN VLADIMIR
3D imaging of live cells with ultraviolet radiation
InactiveUS8143600B2Reconstruction from projectionFluorescence/phosphorescenceOptical tomography3d image
A method for 3D imaging of cells in an optical tomography system includes moving a biological object relatively to a microscope objective to present varying angles of view. The biological object is illuminated with radiation having a spectral bandwidth limited to wavelengths between 150 nm and 390 nm. Radiation transmitted through the biological object and the microscope objective is sensed with a camera from a plurality of differing view angles. A plurality of pseudoprojections of the biological object from the sensed radiation is formed and the plurality of pseudoprojections is reconstructed to form a 3D image of the cell.
Owner:VISIONGATE
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