90 results about "Biological cell" patented technology

A system includes a flow cell and a fluidics system under pressure causing sheath and sample biological fluids to flow. The fluidics system includes a gas bubble remover to remove and eliminate gas bubbles in the sheath fluid. The flow cell receives sheath fluid from the fluidics system, wherein the sample biological fluid flows with cells or particles through the flow cell to be surrounded by the sheath fluid. A deflection chamber under the flow cell receives drops of the sample biological fluid and sheath fluid out of the flow cell to selectively deflect one or more of the drops along one or more deflection paths. A droplet deposition unit system in communication with the deflection chamber receives the selectively deflected drops in the stream of the sample biological fluid with the one or more biological cells or particles into one or more containers.

The utility model provides a biological cell dyeing device and relates to the field of biological cells. Comprising a base, a fixing device is arranged on the upper surface of the base and comprises a sliding plate, the upper surface of the sliding plate is fixedly connected with the fixed end of a first electric telescopic rod, the telescopic end of the first electric telescopic rod is fixedly connected with the middle of the lower surface of a concave frame, and the interior of the upper surface of the concave frame is fixedly connected with one end of a spring; the other end of the spring is fixedly connected with the lower surface of the fixing frame. According to the biological cell dyeing device, through the synergistic effect of a sliding plate, a first electric telescopic rod, a concave frame, a spring and a fixing frame, biological cells can be conveniently dyed, when the biological cells need to be dyed, a cell slide is placed on the fixing frame, the cell slide is fixed through the fixing frame, and the spring plays a buffering role; a first electric telescopic rod is convenient for a worker to quickly take the slide, so that the cell slide is fixed.

Photocatalytic sterilization technology is a technology that uses active substances generated by specific materials under light conditions to kill bacteria, viruses and other microorganisms. This technology mainly relies on the performance of photocatalytic materials, especially semiconductor materials such as titanium dioxide (TiO2). When the photocatalyst is irradiated by light of a specific wavelength, the electrons in the material transition from the valence band to the conduction band, forming electron-hole pairs. These electrons and holes have high chemical activity and can react with water or oxygen to generate free radicals with strong oxidizing ability, which can destroy the cell wall or cell membrane of microorganisms, causing the leakage of intracellular substances, thereby achieving the effect of sterilization. The present application aims to solve the problems of low light utilization rate and insufficient active sites of TiO2 photocatalytic materials, and proposes a TiO2@Ag / Ti-MOF functional material. The TiO2@Ag / Ti-MOF functional material is based on the Ti-MOF skeleton to construct Ag-MOF, realizing the controlled slow release of Ag ions and having a long-term effective sterilization effect.

Systems and methods for encapsulating cells in hydrogel tubes for cell growth within hydrogel tubes are described. In aspects, a system includes a plurality of peristaltic pumps and a plurality of pulse dampeners to provide oscillatory-controlled flow rates of each of a cell solution, a hydrogel solution, and a cross-linking solution to an extruder configured to form hollow hydrogel tubes having suspended biological cells in an interior

The invention discloses a multilayer imaging method for terahertz near-field system tomography, and belongs to the technical field of terahertz near-field imaging. Aiming at the problem that internal depth quantitative calibration is difficult to realize in existing terahertz near-field three-dimensional imaging, the method proposes that a signal with deepest internal imaging is determined through primary scanning, then multiple data processing is carried out through secondary or multiple scanning, bias voltages of different acquired signals are respectively adjusted under the same magnification times, and the internal depth quantitative calibration is realized in the terahertz near-field three-dimensional imaging. The offset values are arranged in an arithmetic progression, thereby obtaining imaging data representing different linear depths. According to the method, multilayer imaging of internal depth calibration can be realized, a three-dimensional tomographic image with quantitative depth information is formed, and the method is suitable for observation of internal structures of biological cells and nondestructive testing of internal defects of materials.

The present invention relates to a method of preparing a microbial cell product, the method comprising: providing an aqueous suspension comprising microbial cells; subjecting said suspension to mechanical cell dissociation at a temperature in the range of 15 DEG C to 35 DEG C, preferably at a pH in the range of 9 to 11, to obtain an aqueous suspension comprising dissociated microbial cells; separating the suspension to provide an extract rich in small cell debris and an extract rich in large cell debris; and combining at least a portion of the extracts to provide the microbial cell product. The invention further relates to a microbial cell product obtained or obtainable by said method. The invention further relates to the use of said products in food products, for example as a replacement for egg white; in animal food; and / or use in cosmetic formulations.

The application relates to the field of sewage treatment, and discloses a sulfur autotrophic denitrification biofilter composite filler and a preparation method thereof. The method comprises the following steps: carrying out a silane hydrolysis reaction on a silane coupling agent containing a mercaptan group to prepare a hydrolysis solution, and then adding hydroxylated polystyrene microspheres into the hydrolysis solution to carry out a grafting reaction and prepare the sulfur autotrophic denitrification biofilter composite filler. The method grafts mercaptan groups to the surface of the polystyrene microspheres by using the silane coupling agent containing the mercaptan group. The mercaptan groups can specifically combine with sulfur transport proteins on the cell membrane of sulfur autotrophic denitrification microorganisms, so that the sulfur autotrophic denitrification microorganisms can selectively colonize on the surface of the polystyrene microspheres, competition between other microorganisms and the sulfur autotrophic microorganisms can be avoided, the colonization stability of the sulfur autotrophic microorganisms is improved, and the biofilm formation efficiency is improved.

A self-organizing swarm robot system and control method based on cellular soft and hard mechanisms are disclosed. The system includes several individual robots. Each robot includes an upper shell, a middle support, a lower support chassis, electrically driven legs, a magnetically connected actuator, a PCB control board, and light-emitting elements. The PCB control board is equipped with an ESP-NOW wireless communication module, a light sensor, and a multi-pose sensor. The magnetically connected actuator includes static and dynamic actuators alternately distributed along the circumference. This invention can simulate the adhesion force regulation and morphological expansion and contraction mechanism between biological cells, achieving dynamic control between swarm robots under mechanical action. It exhibits high flexibility and fast response speed, enabling multi-degree-of-freedom movement and posture adjustment in complex environments. By using ESP-NOW wireless communication technology in conjunction with light sensors and multi-pose sensors to construct a high-precision distributed sensing and control system, it supports the self-organization, collaboration, and task execution capabilities of swarm robots in weak information environments.

The invention discloses a tyrosinase near-infrared fluorescent probe as well as a preparation method and application thereof, and belongs to the technical field of analytical chemistry. According to the technical scheme, the tyrosinase near-infrared fluorescent probe is characterized in that the structural formula of the tyrosinase near-infrared fluorescent probe is shown in the specification. The invention further specifically discloses a preparation method of the tyrosinase near-infrared fluorescent probe and application of the tyrosinase near-infrared fluorescent probe to selective detection of tyrosinase in a water environment, a biological cell system and living organisms. The near-infrared fluorescent probe disclosed by the invention has the advantages of fluorescence emission in a near-infrared region, good selectivity, high sensitivity and the like.

The application discloses a system and method for controlling liposome drug directional delivery based on a spectrum space phase gradient light field, and belongs to the technical field of light field regulation of biological cells; in the application, quasi-plane waves are irradiated onto a spatial light modulator, the amplitude of a target light field is embedded into a phase by using Fourier expansion, and then a holographic template of the reconstructed light field is generated; the holographic template is loaded onto the spatial light modulator, and after filtering through a 4f system, the light beam is projected to an objective lens; on the focal plane of the objective lens, with the help of the existence of the phase gradient, the drug-loaded liposome is transported along a preset track in a directional manner, and is captured by an intensity gradient optical trap at the end of the track; the application can design any drug delivery track according to requirements, and without moving the equipment platform, the two manipulations of any track delivery and target capture can be realized through a single light beam, and the convenience and efficiency of drug directional delivery are improved.

The invention discloses a novel molecular chaperone-mediated autophagy (CMA) activating agent, relates to the technical field of biological cells, and is characterized in that the novel molecular chaperone-mediated autophagy activating agent is a novel anti-tumor drug chidamide, and the novel molecular chaperone-mediated autophagy activating agent is a novel anti-tumor drug chidamide. The chidamide can obviously up-regulate the mRNA and protein level of the key protein LAMP2A in the CMA process. According to the present invention, by constructing a human THP1-LAMP2luciferase reporter gene system, the compound capable of activating the LAMP2 promoter is screened from the bulk drug; through cell level primary screening, secondary screening and animal level verification, an effective CMA activator chidamide is finally determined. A good tool is provided for basic research of CMA, and novel drugs are further researched and developed by taking CMA as a target spot.

The present invention relates to a method and platform for generating CAR-T cells and processing biological cells within a single functionally closed container. The method involves introducing host cells into a sealed container with multiple sterile channels, performing genetic modifications, and maintaining the cells under controlled conditions monitored by real-time feedback until a desired fraction of genetically modified cells is obtained. The container also supports target cell separation using antibody or aptamer functionalized buoyant microbubbles, facilitating the separation of target cells from non-target cells during centrifugation. Waste separation and cell harvesting are performed using pneumatic pressure, enabling high purity cell recovery. The platform includes modules for cell enrichment, sequestration, and isolation, enabling high recovery and high purity of therapeutic cell populations. This integrated closed system approach ensures sterile conditions, efficient processing, and high quality cell products for advanced therapeutic applications.

Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.

The invention discloses a reactive copper ion near-infrared fluorescent probe as well as a preparation method and application thereof, and belongs to the technical field of copper ion near-infrared fluorescent probes. According to the technical scheme, the reactive copper ion near-infrared fluorescent probe is characterized in that the structural formula of the reactive copper ion near-infrared fluorescent probe is shown in the specification. The invention further specifically discloses a preparation method of the reactive copper ion near-infrared fluorescent probe and application of the reactive copper ion near-infrared fluorescent probe to selective detection of copper ions in an aqueous solution, a biological cell system and animal tissue. The near-infrared fluorescent probe disclosed by the invention has the advantages of fluorescence emission in a near-infrared region, good selectivity, low detection limit and the like.

The present invention relates to a system for collecting, separating, concentrating, and reinfusing blood components from whole blood. The system further includes cell modification. The system includes a blood processing device and a fluid flow circuit.

The invention relates to the technical field of biological cells, in particular to a method for forming a derived mammary gland organoid based on induced differentiation of pluripotent stem cells, the adopted culture technical means is no longer rough, more specific and refined, different culture media are customized and used in different stages of cell reproduction, and the culture efficiency is greatly improved. And the old culture medium is taken out in time to replace a proper amount of new and appropriate culture medium, so that normal proliferation of cells is promoted, cell death is reduced, and the pluripotent stem cells can be quickly differentiated to form the derived mammary gland organs. The method is supported by national key research and development plan projects, the project name is microenvironment adaptive type organoid assembly technology research and development based on full liquid phase printing, and the project number is 2024YFC3407600.

The invention discloses a multi-scene inflatable portable cell culture device, and relates to the technical field of biological cell culture.The device comprises a culture cabin, a system cabin and an air cabin, the culture cabin is of a three-layer structure comprising a wear-resistant layer, an inflatable layer and an antibacterial layer and is connected with the system cabin and the air cabin through a double-layer zipper, and the culture cabin is provided with a transparent window and an openable double-layer bottom plate; and a zipper assembly with an automatic sealing structure is connected between the bottom plate and the culture cabin. A heating plate and a temperature sensor are arranged in the antibacterial layer, the system cabin is provided with a temperature controller, a gas controller and a control panel, and the gas cabin is provided with a gas pump and a gas cylinder, supplies gas to the inflation layer and the culture cabin respectively and is electrically connected with the gas controller. The culture cabin of the device can be folded and stored, is good in portability, can be arranged outside a scientific research instrument in a sleeving manner to construct a culture environment in situ, is adaptive to multiple experiment scenes, can accurately regulate and control temperature and gas parameters of the culture cabin, is good in sealing antibacterial activity and convenient to operate, and solves the problems that a traditional culture box is poor in portability and cannot be matched with the scientific research instrument for use.

The invention provides an oscillation mixing device for biological cell culture, and belongs to the technical field of cell culture.The oscillation mixing device comprises a shell, an openable shell door is arranged on the front side of the shell, an inner cavity is reserved in the shell, an oscillation unit is arranged at the bottom of the inner cavity, and an assembly table is arranged on the oscillation unit; a containing unit is arranged on the upper portion of the assembling table, substrates are arranged on the two sides of the upper portion of the assembling table, first linkage units are arranged on the sides, close to each other, of the substrates, the first linkage units are provided with high-low displacement units, and the high-low displacement units are provided with reset units. According to the invention, the problem that the whole culture container is not convenient to load and unload because the culture container close to the outside is convenient to load and unload and the culture container close to the inside needs to be probed and controlled by an operator when the culture container is close to the inside during the constraint of the culture container is solved.

The utility model relates to a cell culture tank exhaust defoaming device, and relates to the technical field of biological cell culture, the cell culture tank exhaust defoaming device comprises a defoaming box connected in series on an exhaust pipe, the defoaming box is located between an exhaust filter and a culture tank, a defoaming cavity for gas circulation is arranged in the defoaming box, and the defoaming cavity is filled with a defoaming wire mesh. The defoaming device is simple in structure, small in equipment size and easy to operate, and the defoaming process is simplified.

The invention relates to the technical field of functional boards, in particular to an antibacterial food-grade board and a preparation method thereof.The antibacterial food-grade board is prepared from, by weight, 100 parts of polypropylene resin, 5-15 parts of a composite additive, 8-12 parts of a functional additive, 0.3-0.8 part of an antioxidant 1010 and 0.5-1.5 parts of calcium stearate. The functional additive is compounded with sulfamic acid and a reaction solution containing epsilon-polylysine, epsilon-polylysine can destroy the completeness of bacterial cell membranes and exerts a long-acting antibacterial effect with other substances in the additive through chemical bonding, and the functional additive is compounded with a fructus cnidii extract by utilizing active ingredients of Chinese prickly ash seeds, so that the antibacterial effect of the functional additive is improved. The antibacterial effect is enhanced by destroying a microbial cell membrane structure, and the antibacterial property and food safety of the plate are effectively improved.

The application provides a photobioreactor, comprising: a solution tank for containing a culture solution; a gas supply module arranged at least partially in the solution tank for releasing vortex ring bubbles and small bubbles into the culture solution respectively; a monitoring module comprising a pH sensor and an optical sensor, the pH sensor being arranged in the solution tank for monitoring the pH value of the culture solution to obtain a pH value signal, the optical sensor being arranged on a side wall of the solution tank for monitoring the wall surface of the side wall to obtain a deposition signal; and a control module electrically connected with the monitoring module and the gas supply module, the control module being configured to receive the pH value signal and the deposition signal and to control the gas supply module to release the vortex ring bubbles or the small bubbles. The photobioreactor provided by the application is beneficial to improving the yield of photosynthetic organism cells. The application further provides a photobioreactor aeration method.

The invention relates to a method and device for analysing antimicrobial compound susceptibility of pathogenic microorganisms in body fluid samples. The method includes the steps of providing at least one body fluid sample, filtering the at least one body fluid sample through at least one catch filter which is configured for capturing at least a fraction of pathogenic microorganisms from the at least one body fluid sample if present in the body fluid sample, applying at least one antimicrobial compound to at least part of the at least one catch filter, in particular to the fraction of pathogenic microorganisms, such that at least a fraction of the captured pathogenic microorganisms extracellularly secrete antimicrobial responsive biomolecules, analysing the extracellularly secreted antimicrobial responsive biomolecules and determining at least one susceptibility characteristic thereof, and comparing at least one determined susceptibility characteristic with at least one reference characteristic corresponding to the at least one determined susceptibility characteristic thereby determining the susceptibility of at least part of the captured pathogenic microorganisms to the at least one antimicrobial compound.

The utility model relates to ship device technical field, specifically disclose a marine special marine organism overall killing subassembly, include: centrifugal pump, still include: first filter assembly, first filter assembly sets up one side at centrifugal pump, and first filter assembly is used for filtering seawater, connecting pipe three, the input of connecting pipe three is fixedly connected with the output of centrifugal pump, the output of connecting pipe three is fixedly connected with shell no.

The utility model provides a kind of biological cell separation device, it is related to biological cell separation technical field, including separation seat, the separation seat side top edge is fixedly installed with several connection rings of the annular array distribution around separation seat center, any the coaxial distribution and fixed mounting in the base of the connection ring below separation seat side middle position is provided with, and any the circular ring and rotating seat are arranged in the position above and below of the connection ring, by being provided with several roller frame in circular ring and rotating seat, the clamping force even distribution is realized in the tube orifice and tube bottom of test tube using several roller frame resistance test tube surface, avoid test tube swing in the process of rotation, and using rotating seat rotation drives the revolution of several roller frame inside to further realize test tube rotation, the tire of roller frame in circular ring can rotate independently, when test tube rotation, the tire of roller frame in circular ring rotates under the action of friction force, further stabilize test tube tube orifice.

The application discloses a kind of water turbine generator unit overflow water quality silt characteristic detection ball and detection system, belong to hydroelectric generating set monitoring technical field, comprising: spherical shell;Water sample collection component and air bag component are located inside spherical shell and along the center symmetry distribution of spherical shell;Water sample collection component includes trigger type water sample collector and trigger in the inside of spherical shell, bottom is connected with each other side by side by connecting rod, trigger is connected with the inner wall of spherical shell by multiple electric contacts;Air bag component includes air bag attached to the surface of spherical shell and built-in gas cylinder and solenoid valve, solenoid valve is connected with the inner wall of spherical shell by multiple electric contacts, air bag and gas cylinder are connected with solenoid valve by different pipelines.The detection ball of the application adopts the structure design similar to biological cell, and respectively on the inside and outside of ball is reserved for installing quick water sample collection device and specific position of quick floating device, can quickly realize the floating and recovery of detection ball.

A technique for measuring the electrical resistance of biological cells or tissues with high efficiency and with high accuracy is provided. An electrode substrate includes: a substrate having a base section, a first extension part extending from the base section, and a second extension part extending from the base section; a plurality of connection terminals provided on a first main surface of the substrate; a first working electrode and a second working electrode each connected to one of said connection terminals, the first and second working electrodes being wired on the first main surface of the substrate; and an engagement surface provided on the substrate and facing toward the connection terminals in a position closer to the first extension part than the connection terminals. The first working electrode is wired from the base section to the first extension part. The second working electrode is wired from the base section to the second extension part.

1. Name of the design product: stainless steel liquid nitrogen tank. 2. Use of the design product: stainless steel liquid nitrogen tank for storing biological samples such as biological cells, embryos, blood bags, etc. 3. Design points of the design product: in shape. 4. Picture or photo that best indicates the design points: perspective view.

The invention relates to the technical field of biological cells, in particular to a recovery culture and passage method of human induced multifunctional stem cells, the adopted culture technical means is no longer rough, more specific and refined, the success rate of obtaining the multifunctional stem cells is high, the probability that the multifunctional stem cells cannot survive is reduced, and the survival rate of the multifunctional stem cells is increased. The efficient and high-success-rate culture of the multifunctional stem cells is facilitated, and large-scale recovery and subculture can be realized.