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1821 results about "Human skin" patented technology

The human skin is the outer covering of the body and is the largest organ of the integumentary system. The skin has up to seven layers of ectodermal tissue and guards the underlying muscles, bones, ligaments and internal organs. Human skin is similar to most of the other mammals skin, and it is very similar to pig skin. Though nearly all human skin is covered with hair follicles, it can appear hairless. There are two general types of skin, hairy and glabrous skin (hairless). The adjective cutaneous literally means "of the skin" (from Latin cutis, skin).

Dynamic overlapping of moving objects with real and virtual scenes for video see-through (VST) extended reality (XR)

A method includes obtaining image frames of a scene captured using one or more imaging sensors of a video see-through (VST) extended reality (XR) device and depth data associated with the scene. The image frames capture a moving object and static scene contents, and the moving object includes a portion of a body of a user. The method also includes generating masks associated with the moving object using a machine learning model trained to separate pixels corresponding to human skin from other portions of the scene. The method further includes reconstructing images of the moving object and images of the static scene contents. In addition, the method includes combining the images of the moving object, the images of the static scene contents, and one or more virtual features to generate combined images and rendering the combined images for presentation on at least one display of the VST XR device.
Owner:SAMSUNG ELECTRONICS CO LTD

Process for exfoliating human skin

A process for exfoliating the skin, including the scalp, and / or the nails, comprising the step consisting in subjecting a surface of said skin (K), or said nails, to a cosmetic composition and to ultrasonic acoustic waves emitted by a device comprising at least one ultrasonic transducer (13), with an acoustic intensity Isata in the region exposed to the acoustic waves that is at least equal to 0.1 W / cm2, i) the transducer being moved relative to said surface at an average sweeping speed of between 0.01 cm2 / s and 15 cm2 / s for the duration of treatment of said surface, and / or ii) the device being applied to a location on the keratin material, then moved away from the latter and applied to a different location.
Owner:LOREAL SA

Closed-loop noninvasive spinal cord electrical stimulation regulation and control method and system based on motion data

The invention discloses a closed-loop noninvasive spinal cord electrical stimulation regulation and control method and system based on motion data, and the system is provided with a flexible electrode array patch which is attached to the skin surface of a to-be-tested human body; the sensing module is used for collecting electromyographic signals or acceleration signals of a user; the signals are processed, and characteristic values related to actions and motions are extracted; the closed-loop feedback module compares the characteristic value with a model set characteristic / threshold value, and judges whether to start stimulation site and stimulation parameter adjustment or not; automatically selecting an optimal electrode unit and a corresponding stimulation parameter based on a judgment result; the dynamic regulation and control module controls the optimal electrode unit to output stimulation current, and regulates the activity of corresponding spinal cord neurons; and continuously performing closed-loop adjustment on the electrode unit and the stimulation parameters according to the motion feedback data. According to the method and system, precise stimulation and closed-loop regulation and control based on the motion response of the patient are achieved, and the problems that stimulation target positioning depends on artificial experience, parameter adjustment is not timely, and individualized and closed-loop feedback capacity is lacked are solved.
Owner:SPACE ERA (BEIJING) TECH CO LTD

Multifunctional warp-knitted ice-feeling heat-shielding and sun-blocking fabric

The utility model discloses a multifunctional warp-knitted ice-feeling heat-shielding sunscreen fabric which comprises first yarn and second yarn, the first yarn is full-dull special-shaped section chinlon filaments with the specification of FDY45Dtex / 48F, and the second yarn is high-temperature-resistant spandex filaments with the specification of 40dTEX. The first yarns and the second yarns are separately perforated for weaving, so that the first yarns cover the second yarns, namely, the first yarns are exposed on the inner side, and as the first yarns adopt the chinlon filaments with cool feeling, when the fabric body is in contact with the skin of a human body, the first yarns are in contact with the skin of the human body; the first yarns with larger areas are in contact with the skin of a human body, so that a better cool feeling is kept; moreover, the first yarns and the second yarns are thin, so that the fabric body is thin, and the air permeability is good; moreover, due to the fact that the first yarn and the second yarn are woven in a high-density mode, the density of the fabric body is high, ultraviolet rays are not prone to penetrating through the fabric body, and the sunscreen effect is achieved.
Owner:FUJIAN XINGXINBAO IND & TRADE CO LTD +1

Mosquito detection and cooperative killing system and method

The invention provides a mosquito detection and cooperative killing system and method.The mosquito detection and cooperative killing system comprises a bionic multi-mode sensor array and a dynamic feedback killing device, and the bionic multi-mode sensor array comprises an infrared sensing module used for simulating human skin radiation characteristics; the CO2 concentration gradient sensor is used for detecting the change of the concentration of carbon dioxide and activating the directional scanning of the infrared sensing module; the odor molecule release device is used for triggering a mosquito approaching behavior; the dynamic feedback killing device is used for starting the laser mosquito killing module and killing mosquitoes through infrared positioning coordinates. According to the technical scheme, the mosquito killing effect is improved.
Owner:新疆第二医学院

Human skin temperature prediction method and system fusing informer and STGCN

The invention relates to the technical field of human body temperature prediction, and provides a human body skin temperature prediction method and system fusing an informer and STGCN. The method comprises the following steps: according to a topological structure among a plurality of measurement points of acquired skin temperature data of a target object, based on a space-time diagram convolutional network, extracting space time sequence characteristics of the measurement points, and based on a first informer module of a self-attention mechanism, respectively according to a data matrix of the skin temperature data and a data matrix of acquired environmental parameter data; respectively extracting temperature time sequence characteristics and environment time sequence characteristics of the measurement points; and then, fusing the space time sequence characteristics, the temperature time sequence characteristics and the environment time sequence characteristics of the measurement points in a second informer module based on a self-attention mechanism according to a time sequence, inputting an obtained characteristic matrix into a full-connection neural network, and predicting the skin temperature of a target measurement point.
Owner:CHINESE PEOPLE'S PUBLIC SECURITY UNIVERSITY

Systems and methods for multivariate stroke detection

A system for detecting an anomalous biologic event in a person includes a wearable device for monitoring skin surface sites of a person. The wearable device includes an electrode for contacting skin sites, an electronic stimulus source with a surface area to provide stimulus, and a sensor placed adjacent the skin sites to sense physiological data. A processor is coupled to the wearable device and is configured to: cause the stimulus source to generate a stimulus; excite the electrode to trigger monitoring the skin sites; cause operation of the sensor; receive bioelectrical data from each skin site; receive physiological data from the sensor; continuously compute a difference in the received bioelectrical data for a duration; compute a difference in the received physiological data at time intervals; and generate, based on the computation, an assessment including a likelihood of occurrence of the anomalous biologic event.
Owner:KANDU HEALTH INC

Collagen fusion polypeptide as well as application and preparation method thereof

The invention belongs to the field of synthetic biology, and particularly relates to collagen fusion polypeptide as well as application and a preparation method thereof. The collagen fusion polypeptide provided by the invention comprises: (a) a first polypeptide of recombinant III-type collagen; and (b) a second polypeptide comprising a trimerized folding domain. The collagen fusion polypeptide provided by the invention has the advantages of low immunogenicity, good biocompatibility, high biological activity and the like, can significantly promote proliferation and migration of human skin fibroblasts, and has stronger ability of promoting regeneration of endogenous collagen. The collagen fusion polypeptide has a triple helix structure similar to natural collagen, and can be self-assembled to form collagenous fibers which are good in morphology and similar to natural collagen. The method can be widely applied to the fields of skin repair dressings, biological materials, artificial implants, medical instruments, cosmetics, health care products, food and the like.
Owner:SHANGHAI CHANGING BIOTECH CO LTD +1

Wearable aptamer electrochemical sensor as well as preparation method and application thereof

The invention relates to a wearable aptamer electrochemical sensor and a preparation method and application thereof, and belongs to the field of wearable sensors, and the preparation method comprises the following steps: 1) preparing an electrochemical sensing unit on a flexible substrate, including a TNF-alpha working electrode, a sodium ion working electrode and a pH working electrode; 2) preparing a microfluidic layer with a sweat detection channel; and 3) combining the flexible substrate with the microfluidic layer, and correspondingly fitting the electrochemical sensing unit with the sweat detection channel so as to monitor TNF-alpha, sodium ions and pH in sweat. By adopting the overall flexible design, the sweat TNF-alpha monitoring device is suitable for noninvasive and dynamic monitoring of human body inflammatory factors in a resting state, and the accuracy of sweat TNF-alpha monitoring can be improved; the non-invasive monitoring problem of high sensitivity, high specificity, high accuracy and high stability of sweat inflammatory factors in a non-motion state is solved, and the prepared electrochemical sensor can be attached to the surface of human skin and can be further applied to monitoring and management of inflammatory diseases and related fields.
Owner:XIAMEN UNIV

Respiration monitoring system based on flexible strain sensor and monitoring analysis method

The invention discloses a respiration monitoring system based on a flexible strain sensor and a monitoring analysis method, and belongs to the technical field of sensors and respiration monitoring equipment. The respiration monitoring system comprises a flexible strain sensor, a connecting line, a data acquisition card and an upper computer; the flexible strain sensor is a band-aid type flexible strain sensor and can be directly adhered to the skin surface of a human body, and the deformation of muscles related to respiration is monitored and converted into the change of a resistance signal. And the flexible strain sensor is connected with the data acquisition card through a connecting line. And the data acquisition card is connected with the upper computer and is used for transmitting the acquired resistance signals to the upper computer. The quantitative breathing mode judgment standard is provided through dynamic measurement of the respiratory muscle group, and the defect that judgment is mainly conducted through naked eyes of doctors for a long time can be overcome; the relation between the respiratory muscle group deformation and the lung function parameters is associated, and the problem that the actual respiration condition of part of patients does not conform to the detection condition in conventional lung function detection can be solved.
Owner:DALIAN UNIV OF TECH

Recombinant humanized elastin with high biological activity as well as preparation method and application of recombinant humanized elastin

The invention provides a recombinant humanized elastin with high biological activity as well as a preparation method and application thereof, and belongs to the technical field of genetic engineering and biological materials. 100% of the amino acid sequence of the elastin is derived from human elastin and is prepared by expression of genetically engineered bacteria; the protein has a typical beta-spiral hydrophobic structural domain and a lysine-rich hydrophilic structural domain, has a good bionic structure and functional characteristics, can significantly promote proliferation, adhesion and migration of human skin fibroblasts, also has excellent antioxidant, anti-wrinkle and anti-aging activities, and can be used for preparing a biomimetic protein. The hydrogel can be widely applied to the fields of skin repair dressings, injection implants, artificial skin, biomedical materials, functional skin care products and the like; in addition, the elastin is good in solubility, high in stability, mature in expression system and suitable for large-scale production.
Owner:GUANGZHOU ADVANCED REGENERATIVE MEDICINE TECH CO LTD

Application of sea cucumber-derived nano-vesicles in preparation of medicine for promoting wound repair

The invention relates to application of sea cucumber-derived nano-vesicles in preparation of a medicine for promoting wound repair. The nano-vesicles (SC-EVs) extracted and prepared from sea cucumbers can effectively promote cell migration, scratch repair and tube forming capabilities of human skin epithelial cells (HACAT) and human skin microvascular endothelial cells (HM DEC) and inhibit cell apoptosis, so that the capability of repairing cells is achieved, and particularly the effect of repairing wound surfaces in a high glucose state or diabetes mellitus is achieved. The invention provides a new direction and thought for the application of the sea cucumber-sourced nano vesicles (SC-EVs), provides a brand new drug research and development and clinical treatment direction for wound repair, especially for solving the problem of difficult healing of wounds of patients with high glucose or diabetes, and has extremely high social value and market application prospect.
Owner:JINAN UNIVERSITY

Spirit skin extract as well as preparation method and application thereof

The invention discloses a spirulina platense skin extract as well as a preparation method and application thereof, and relates to the technical field of biomedicine. The obscured spirulina skin extract is rich in various active ingredients including collagen family members, viscose protein, C1Q complement protein, fibronectin and the like, and the ingredients complement and promote one another, so that the extract has remarkable effects in the aspects of skin aging resistance, skin injury repair and the like; therefore, the method has a wide application prospect in medicine research and development, cosmetics and functional foods. According to the extraction method of the skin protein of the obtuse spirulina, the sample is subjected to rapid freeze thawing treatment, and the steps of mechanical crushing, ultrasonic-assisted separation and multiple filtration are combined, so that the influence on the activity of the product is avoided, and various compound proteins can be obtained; the pH value of a buffer solution is adjusted, the property of the extract is further optimized, and the extract is more suitable for human skin, is sterile and can be directly used as a product raw material, so that large-scale production is realized, and industrial application of the obtuse spirulina skin extract is promoted.
Owner:BGI RESEARCH HANGZHOU +3

Vital sign detection method based on millimeter wave radar and camera fusion

The invention relates to the technical field of image processing, and provides a vital sign detection method based on millimeter-wave radar and camera fusion, which comprises the following steps: performing posture detection based on a human body image of a target person to obtain a chest area of the target person, and performing frequency analysis on a millimeter-wave radar signal to obtain a distance angle heat map; performing human body positioning based on the chest area and the distance angle heat map to obtain a human body position; based on the human body position, phase extraction is carried out on the millimeter wave radar signal to obtain the vital sign signal of the target person, variational mode decomposition is carried out on the vital sign signal to obtain the vital sign parameter of the target person, and the defects that current detection is easily influenced by the human body skin state, the detection result is inaccurate, and the detection accuracy is high are overcome. The system has the advantages that the defects of limitation on special crowds, continuous monitoring and remote monitoring are overcome, non-invasive detection is realized, the detection result is more accurate and reliable, the system is more beneficial to the special crowds, and support is provided for family medical treatment and remote health monitoring.
Owner:INST OF AUTOMATION CHINESE ACAD OF SCI

Traditional Chinese medicine fermentation extracting solution as well as preparation method and application thereof

The invention provides a traditional Chinese medicine fermentation extracting solution and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine cosmetics. A traditional Chinese medicine composition which is composed of sophora flower bud, clove, honeysuckle, citron, astragalus membranaceus, houttuynia cordata, turmeric, emblic leafflower fruit, rehmannia and roselle and has an anti-aging effect is reasonably combined, and the traditional Chinese medicine fermented extract is obtained after the traditional Chinese medicine composition is fermented for multiple times by utilizing compound probiotics. The traditional Chinese medicine fermentation extract has a strong free radical scavenging effect, has an obvious improvement effect on cell activity, can obviously inhibit matrix protease activity, can obviously improve MDA content in serum of an aging mouse model and indexes of SOD, CAT, GSH-Px activity and the like, and has obvious anti-oxidation and anti-aging effects. The traditional Chinese medicine fermentation extracting solution provided by the invention can be used for preparing anti-aging cosmetics or functional foods, is safe and non-irritant when being used for human skin, and has an obvious improvement effect on the elasticity, wrinkles and smoothness of the human skin.
Owner:WANG SHUHE BIOMEDICINE (WUHAN) CO LTD

Light therapy beauty patch (HD-77)

1. The name of the product of this design: Light Therapy Beauty Patch (HD‑77). 2. Purpose of the product of this design: used for phototherapy and physical therapy of human skin. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.
Owner:SHENZHEN NUON MEDICAL EQUIPMENT CO LTD

Moisturizing cream prepared from lysate extract produced by fermentation of bacillus subtilis

The invention discloses a moisturizer prepared from a lysate extract produced by fermentation of bacillus subtilis. The hydroxydecyl ubiquinone is identified in Y-3FLE, and the yield of the hydroxydecyl ubiquinone is 0.45 mu g / g after the hydroxydecyl ubiquinone is cultured for 4 days, so that the quinone substances are identified in the Halophilic bacteria in the Yuncheng Salt Lake for the first time. The Y-3FLE is prepared by adopting absolute ethyl alcohol as a solvent, the oxidation resistance of the Y-3FLE is investigated through an in-vitro experiment, and a result shows that the Y-3FLE is relatively high in reducing capacity and relatively high in oxidation resistance. A human body closed patch test result shows that the Y-3FLE has no obvious irritation to human skin. The method is applied to the moisturizer, and human body efficacy evaluation is carried out through a multi-probe skin tester. Results show that the moisturizer added with 1% of Y-3FLE has multiple remarkable effects of moisturizing, repairing, nourishing and the like.
Owner:NAFINE CHEMICAL IND GROUP CO LTD YUNCHENG

Lie detection system based on AC excitation multi-frequency skin electric signals and method thereof

The invention discloses a lie detection system and method based on AC excitation multi-frequency skin electric signals, and belongs to the technical field of psychological and physiological detection and signal processing. According to the system, a multi-frequency AC excitation signal is applied to human skin, skin complex impedance is measured by adopting a four-electrode method, and the problems of electrode polarization and baseline drift of direct current excitation are solved. A high-dimensional feature vector is formed by extracting the amplitude, phase and differential ratio of multi-frequency impedance and Cole-Cole relaxation model parameters, and an individualized baseline is established. Feature changes are analyzed through a machine learning algorithm, and lie judgment is achieved. The method has the advantages of strong anti-interference capability, abundant information dimensions, high measurement accuracy and good safety.
Owner:BEIJING QINGFENG QIHANG TECHNOLOGY CO LTD

Methods and chemical compositions for treating skin conditions by providing long lasting skin PH control for improving skin barrier function

Provided are methods and composition for treating skin barrier functions and associated disorders. Formulated compositions may be applied on human skin to maintain a desired skin surface pH over an extended period of time without irritating the skin. Maintaining the desired surface pH aids in treatment of eczema, in addition to other skin conditions.
Owner:SOTERI SKIN INC

Composition capable of improving water retention and water locking capacity of skin and preparation method of composition

The invention relates to the technical field of health-care food, in particular to a composition capable of improving water retention and water locking capacity of skin and a preparation method of the composition. Comprising the following steps: preparing starch salmon nasal cartilage composite nano powder; preparing flavor moisturizing tremella polysaccharide fermentation liquor; and light enzymolysis of the salmon nasal cartilage and compounding of the salmon nasal cartilage and the tremella polysaccharide fermentation liquor. According to the invention, the lactobacillus kefiranofaciens kluyveromyces marxianus subsp. Kefiranofaciens ZW3 bacterial liquid, the kluyveromyces marxianus bacterial liquid and the bacillus subtilis DE111 bacterial liquid which are activated and propagated according to a certain proportion are mixed to prepare the compound bacterial liquid, and then the tremella fuciformis extracting solution is fermented, so that the flavor and taste of the tremella fuciformis extracting solution can be improved, the fermentation effect can be enhanced, and the quality of the tremella fuciformis is improved. Healthy nutritional ingredients such as microbial protein, vitamins and amino acid can be efficiently generated, the antioxidant capacity is enhanced, and the prepared flavored moisturizing tremella polysaccharide fermentation liquor is rich in nutritional ingredients and can improve the antioxidant capacity and the water retention and moisturizing capacity of human skin after being taken into a human body.
Owner:SHANDONG LONGBEI BIOTECHNOLOGY CO LTD +1

Freeze-dried facial mask

The invention provides a freeze-dried mask. The freeze-dried mask is prepared from the following raw materials in parts by weight: 70 to 90 parts of deionized water, 15 to 25 parts of algae extract, 3 to 5 parts of mannitol, 0.5 to 1 part of glycerol, 0.3 to 0.5 part of hydrolyzed collagen, 1 to 3 parts of amino acid mixture, 4 to 6 parts of hydroxypropyl tetrahydropyrantriol, 3 to 5 parts of tetrahydromethylpyrimidine carboxylic acid and 2 to 4 parts of hyaluronic acid. According to the freeze-dried mask disclosed by the invention, natural anti-wrinkle and moisturizing components such as the hydrolyzed collagen, the algae extract, the amino acid mixture and the hyaluronic acid are locked on the mask cloth in a freeze-drying manner, so that on one hand, the freeze-dried mask can better supplement moisture and nutrition for human skin when being used; on the other hand, the freeze-dried facial mask prepared from the natural beautifying and skin-care components is free of any irritating component during use, and does not cause damage to the human skin.
Owner:ONUGE PERSONAL CARE (GUANGDONG) MANUFACTURER GROUP CO LTD

Beauty instrument accessory head and beauty instrument

This application discloses a beauty instrument accessory head and a beauty instrument, the beauty instrument accessory head comprising: an outer cover, configured to be detachably connected to a beauty instrument body, and comprising a contact outer surface and a connection outer surface; a conductive member, disposed on the outer cover, and comprising a first end face exposed on the contact outer surface and a second end face exposed on the connection outer surface, the first end face in contact with human skin, and the second end face in contact with a cold compress component of the beauty instrument body; and an elastic member, disposed between the outer cover and the conductive member, one end of the elastic member acting on the outer cover, and the other end of the elastic member acting on the conductive member, allowing the conductive member being attached to the cold compress component.
Owner:HANGZHOU ULIKE TECHNOLOGY CO LTD

Multifunctional printing and dyeing dye and application thereof in outdoor clothes

The invention discloses a multifunctional printing and dyeing dye and application thereof in outdoor clothes, and belongs to the technical field of nylon printing and dyeing, the multifunctional printing and dyeing dye comprises 1-3% (o.w.f) of an acid dye, 1.5-3.5 g / L of a dyeing auxiliary agent, and 0.6-1 g / L of an auxiliary agent cross-linking agent; the dyeing auxiliary agent is a core-crosslinked star-shaped polymer prepared by an arm-first method; dyeing can be changed into color fixation by adjusting the pH value and the bath ratio of the dye bath without additionally preparing a color fixation solution, so that the additional water consumption required by color fixation is reduced; the adopted dyeing auxiliary is a core cross-linked star-shaped polymer prepared by an arm method, and the ultraviolet light absorber is coated in a core, so that the light stability and washability of the ultraviolet light absorber are improved, the mobility is reduced, and the problem of sensitive skin stimulation caused by long-term contact with human skin after the ultraviolet light absorber is migrated to the surface of the fabric is prevented.
Owner:ZHEJIANG YUEXIN PRINTING & DYEING CO LTD

A soothing, moisturizing and repairing composition and its application

The present invention provides a soothing, moisturizing and repairing composition and its application, which relates to the technical field of daily chemicals. The present invention has a soothing, moisturizing and repairing composition with Artemisia annua extract, Centella asiatica extract and Gentiana yunnanensis extract as main components, and the raw materials are selected from natural ingredients such as Artemisia annua, Centella asiatica, Gentiana yunnanensis, etc., which is non-toxic and non-irritating to human skin and has high safety; further, the product of the present invention can be used to repair skin damage caused by various reasons, and has anti-inflammatory and moisturizing effects. It is applied to cosmetics and skin care products, such as gel, emulsion, cream, essence, etc., which is gentler to the human body, safe and non-irritating.
Owner:DOCTOR PLANT GUANGDONG BIOTECHNOLOGY CO LTD

Optical Therapy Beauty Instrument (HY-80R)

ActiveCN309407496SHuman skinLight treatment
1. Name of the design product: Phototherapy Beauty Instrument (HY-80R). 2. Use of the design product: For phototherapy and beauty treatment of human skin. 3. Design key points of the design product: Lies in the shape. 4. Picture or photo that best shows the design key points: Perspective view.
Owner:SHENZHEN KAIYAN MEDICAL EQUIP CO LTD

Non-contact physiological and psychological health detection device based on AI

The invention provides a non-contact physiological and psychological health detection device based on AI. The non-contact physiological and psychological health detection device comprises a cabinet, a host, a liquid crystal display, a high-precision camera, a multi-wavelength RGB camera, a light supplement lamp, an identity card swiping module, a social security card swiping module, an IC card swiping module, a printer and a power supply. A high-precision camera is adopted to collect a face image of a human body, and face parameters are obtained based on the face image; a multi-wavelength RGB camera is adopted to detect subtle color changes caused by human skin surface pulses, an RPPG technology is utilized to extract blood volume pulse signals, then physiological parameters are obtained, and a deep learning network is utilized to analyze and process the facial parameters and the physiological parameters in real time so as to evaluate the health state of a user. And data visualization is carried out on the result, the facial parameters and the physiological parameters output by the AI analysis module, and the data are displayed in a liquid crystal display, so that a user can better know the health state of the user.
Owner:JIANGSU WEIJU INTELLIGENT TECH CO LTD

Mu-type conotoxin peptide mutant as well as pharmaceutical composition and application thereof

The invention discloses a mu-type conotoxin peptide mutant as well as a pharmaceutical composition and application thereof. The amino acid sequence of the mu-type conotoxin peptide mutant is as shown in SEQ ID NO. 1. Compared with a wild type mu-type conotoxin peptide, the mu-type conotoxin peptide [d-Arg2, Ser17]-dR-mu-CnIIIC disclosed by the invention has higher activity, the animal activity is improved by more than 20 times, and muscle contraction can be effectively reduced by specifically blocking a Nav1.4 channel. In addition, the compound can be used as a non-invasive anti-wrinkle treatment means to reduce or eliminate the formation of wrinkles on the human skin surface, and has a wide application prospect in the fields of medical treatment and beauty.
Owner:PEPTIORIGIN BIOTECHNOLOGY CO LTD

Double-structural-domain recombinant human chemical fibronectin as well as preparation and application of double-structural-domain recombinant human chemical fibronectin

The invention discloses a double-structural-domain recombinant human fibronectin, the sequence of which is shown as SEQ ID NO.3, and the double-structural-domain recombinant human fibronectin is formed by fusing a collagen binding structural domain and a cell binding structural domain of human fibronectin. The invention also provides a recombinant expression vector containing the protein coding gene and a host cell. The protein is efficiently expressed through eukaryotic cells and engineering bacteria escherichia coli, and a fermentation and purification process suitable for an industrial scale is established in a matched manner. Functional experiments prove that compared with commercially available fibronectin products with a single structural domain, the double-structural domain recombinant human chemical fibronectin disclosed by the invention can remarkably promote proliferation, migration, adhesion and differentiation activity of human skin fibroblasts, and has wide application potential in the fields of skin repair, skincare and biomedical materials.
Owner:BAYI MEIHENG (BEIJING) TECH CO LTD

Human skin-like super-resolution tactile sensor and tactile reconstruction method

The invention discloses a human skin-like super-resolution tactile sensor and a tactile reconstruction method. According to the sensor, by referring to the bionic mechanism that different types of receptors are embedded in soft tissues of human skin, functional bionics of various human receptors (such as Pareny bodies, Meisner bodies and the like) are realized by embedding different types of sensing units in different arrangement modes in soft silica gel materials, and further, the sensor can be used for realizing the functional bionics of various human receptors (such as Pareny bodies, Meisner bodies and the like) through a tactile reconstruction method. And large-area and super-resolution sensing of forward pressure, shearing force, torsional force and the like is realized. The sensor is characterized in that the sensor focuses on bionics of human skin tissue functions rather than bionics of human body receptor functions, that is to say, by selecting a soft silica gel material with the maximum force traction coupling effect, the same external contact can cause as many sensing units to generate responses as possible; therefore, human skin-like large-area and super-resolution tactile perception is realized.
Owner:ZHEJIANG UNIV

Therapeutic apparatus

The invention relates to the technical field of medical supplies, and particularly discloses a therapeutic apparatus comprising an acupoint positioning unit comprising an excitation electrode and a measuring electrode, the excitation electrode is configured to generate current to human skin, and the measuring electrode is configured to receive the current and measure a resistance value of the skin to determine an acupoint position; the treatment unit comprises a polylactic acid layer, a temperature-sensitive hydrogel drug layer, a sensor and a plurality of microneedles, the temperature-sensitive hydrogel drug layer is arranged on the polylactic acid layer, the plurality of microneedles are arranged on the temperature-sensitive hydrogel drug layer in a rectangular array, and the sensor is arranged on the temperature-sensitive hydrogel drug layer among the plurality of microneedles; the host comprises a shell, a processor, a memory, a touch screen and an electric heater, the processor and the memory are in data connection and are both installed on a circuit board, the circuit board is arranged in the shell, the touch screen and the electric heater are installed on the shell and are in data connection with the processor, and the therapeutic instrument can achieve precise treatment and is convenient and reliable to use.
Owner:GUANGZHOU UNIVERSITY OF CHINESE MEDICINE