404 results about "Elastin" patented technology

The invention belongs to the technical field of cosmetics, and discloses a composition with tightening and anti-wrinkle effects as well as a preparation method and application thereof. The composition disclosed by the invention comprises the following components: a radix pseudostellariae extract and hydrolyzed ginsenoside. The radix pseudostellariae extract in the composition achieves the effects of tightening and resisting wrinkles by promoting generation of collagen and elastin, the hydrolyzed ginsenoside mainly has the effects of resisting oxidation, inhibiting expression of matrix metalloproteinase and preventing collagen degradation, and after the radix pseudostellariae extract and the hydrolyzed ginsenoside are combined, the composition has a better effect of inhibiting the activity of the matrix metalloproteinase, so that the effect of resisting wrinkles is achieved. The traditional Chinese medicine composition has the effects of promoting the generation of collagen and elastin, and has a synergistic effect, so that the traditional Chinese medicine composition has an excellent anti-aging effect.

The invention provides a structure, a preparation method and an application method of a group of anti-wrinkle compact cyclopeptide compounds. The anti-wrinkle compact cyclic peptide compound comprises an anti-wrinkle cyclic peptide-1 with a sequence of c (CDLARLAMYA), and / or an anti-wrinkle cyclic peptide-2 with a sequence of c (KTFKKTFK). The promotion rates of the anti-wrinkle cyclopeptide-1 to zebra fish collagen gene expression col1a1a, col1a1b and col1a2 under the concentration of 0.001% are respectively 156%, 87% and 103%. The promotion rate of the cyclopeptide on zebra fish elastin Elna gene expression under the test concentration of 0.001% is 132%. Under the concentration of 0.001%, the promotion rates of the anti-wrinkle cyclopeptide-2 on zebra fish collagen gene expression col1a1a, col1a1b and col1a2 are 94%, 84% and 66% respectively. The promotion rate of the cyclopeptide on zebra fish elastin Elna gene expression under the test concentration of 0.001% is 66%.

The present invention discloses a probiotic postbiotic composition for improving the scalp environment, a preparation method thereof and an application thereof, wherein the probiotic postbiotic composition for improving the scalp environment comprises postbiotics obtained by fermenting two strains of Lactobacillus paracasei ProSci-101 and Lactobacillus fermentum ProSci-602; the Lactobacillus paracasei ProSci-101 has a preservation number of CGMCC No.26528; the Lactobacillus fermentum ProSci-602 has a preservation number of CGMCC NO.25451. The probiotic postbiotic composition for improving the scalp environment of the present invention has the effects of cell repair, enhancing elastin and renewing the metabolism of the dermis, can slow down cell aging, and promote the proliferation of stratum corneum cells; thereby effectively achieving the purpose of improving the scalp environment and preventing hair loss.

The invention provides a recombinant humanized elastin with high biological activity as well as a preparation method and application thereof, and belongs to the technical field of genetic engineering and biological materials. 100% of the amino acid sequence of the elastin is derived from human elastin and is prepared by expression of genetically engineered bacteria; the protein has a typical beta-spiral hydrophobic structural domain and a lysine-rich hydrophilic structural domain, has a good bionic structure and functional characteristics, can significantly promote proliferation, adhesion and migration of human skin fibroblasts, also has excellent antioxidant, anti-wrinkle and anti-aging activities, and can be used for preparing a biomimetic protein. The hydrogel can be widely applied to the fields of skin repair dressings, injection implants, artificial skin, biomedical materials, functional skin care products and the like; in addition, the elastin is good in solubility, high in stability, mature in expression system and suitable for large-scale production.

The invention belongs to the technical field of cosmetics, and discloses a wrinkle-removing and anti-aging composition containing recombinant collagen as well as a preparation method and application of the wrinkle-removing and anti-aging composition. The composition is prepared from the following components: 20.4 to 35.6 percent of glycerol, 1.1 to 3.5 percent of 1, 2-hexanediol, 8.2 to 15.4 percent of apple fruit cell culture extract, 1.6 to 3.2 percent of inositol, 0.2 to 1.0 percent of elastin, 0.1 to 1.7 percent of hydroxyproline, 0.1 to 1.0 percent of sodium polyglutamate, 0.1 to 1.0 percent of sodium hyaluronate, 0.01 to 0.1 percent of acetyl hexapeptide-8, 0.01 to 0.1 percent of fibronectin, 1.72 to 3.21 percent of soluble collagen and the balance of deionized water. The amino acid sequence of the soluble collagen is as shown in SEQ ID NO. 1. The skin care product prepared by adding the anti-wrinkle and anti-aging composition is good in safety and has the effects of resisting wrinkles, improving skin elasticity and resisting aging.

The invention relates to a biomarker for predicting the curative effect of non-small cell lung cancer immunotherapy and application of the biomarker. The biomarker for predicting the curative effect of the non-small cell lung cancer immunotherapy, disclosed by the invention, comprises phosphoglycerate kinase 1 (PGK1), chromogranin A (CHGA), elastin (ELN), heterogeneous ribonucleoprotein H3 (HNRNPH3) and SERPINE1 mRNA binding protein 1 (SERBP1). The biomarkers for predicting the non-small cell lung cancer immunotherapy curative effect can be detected by adopting a mass spectrum method, and the non-small cell lung cancer immunotherapy curative effect of a patient is judged by the markers.

The invention relates to bionic bio-ink as well as a preparation method and application thereof, and relates to the technical field of 3D bio-printing. The preparation method of the bionic bio-ink comprises the following steps: sequentially adding methylacryloylated recombinant human collagen, o-nitrobenzyl modified methylacryloylated hyaluronic acid, elastin-like polypeptide and phenyl-2, 4, 6-trimethylbenzoyl lithium phosphonate into a solvent, stirring and uniformly mixing to obtain an ACEM hydrogel precursor solution, and carrying out ultrasonic treatment on the ACEM hydrogel precursor solution to obtain the bionic bio-ink. Uniformly mixing the ACEM hydrogel precursor solution with a photoresist and seed cells to obtain the bionic biological ink. The sequence of the elastin-like polypeptide is as shown in SEQ ID NO. 1. The biological ink is better in mechanical strength, retains the advantages and functions of natural protein, can be quickly photo-cured into a high-strength and dual-network hydrogel structure, and has excellent printability, biocompatibility and cartilage tissue regeneration promoting capacity.

The invention belongs to the technical field of biomedical tissue engineering materials, and particularly relates to injectable composite plastic gel and a preparation method thereof. The injectable plastic gel provided by the invention is formed by suspending and compounding the cross-linked sodium hyaluronate gel particles and the biological tissue extracellular matrix particles, the two material particles in the injectable composite plastic gel are uniform in size and controllable in size, other toxic catalysts do not need to be added in the preparation process, and the injectable plastic gel is easy to prepare. The collagen / elastin composite material is rich in collagen and elastin, and shows good biomechanical properties. Meanwhile, the composite plastic gel contains a plurality of bioactive factors, and after the composite plastic gel is injected and filled into a body, the composite plastic gel is slowly degraded and can promote the generation and ingrowth of autologous fat cells and microvessels, so that the balance of degradation and remodeling is achieved. The preparation method of the injectable plastic gel provided by the invention can be widely applied to the fields of plastic surgery, medical beauty and the like.

The invention relates to a plasma biomarker for predicting the curative effect of non-small cell lung cancer immunotherapy and application of the plasma biomarker. The biomarker for predicting the curative effect of the non-small cell lung cancer immunotherapy, disclosed by the invention, comprises phosphoglycerate kinase 1 (PGK1), fibronectin 1 (FN1), chromogranin A (CHGA), elastin (ELN), heterogeneous ribonucleoprotein H3 (HNRNPH3) and an Aly / REF output factor (ALYREF). The plasma biomarkers for predicting the non-small cell lung cancer immunotherapy curative effect can be detected by adopting a mass spectrum method, and the non-small cell lung cancer immunotherapy curative effect of a patient is judged by the markers.

The invention relates to the technical field of gel separation and extraction, in particular to a precipitation and separation device for elastin gel preparation, which comprises a precipitation cylinder, a liquid outlet is arranged above the circumferential side wall of the precipitation cylinder, and a cleaning ring for cleaning attached gel is arranged in the precipitation cylinder. A cleaning ring is arranged in the precipitation cylinder, a filtering mechanism for intercepting gel is arranged at the center of the cleaning ring, the filtering mechanism is rotatably connected with the cleaning ring, and a driving mechanism for driving the cleaning ring to slide up and down is arranged at the top end of the cleaning ring. The cleaning ring is arranged on the bottom of the precipitation cylinder, elastin gel attached to the inner wall of the precipitation cylinder is effectively scraped, meanwhile, the filtering mechanism moves downwards along with the cleaning ring, the water-phase solution is allowed to penetrate through the filtering mechanism to intercept gel particles, floating and floating of the gel particles in the water-phase solution are avoided, it is ensured that the gel particles can be smoothly precipitated to the bottom of a container, and the recovery efficiency of the gel is improved.

The invention relates to a regenerated decellularized adipose derivative as well as a preparation method and application thereof. The preparation raw material of the regenerated decellularized adipose derivative is prepared from a vascular matrix component (SVF) separated from human adipose tissue through decellularization treatment and freeze drying; the prepared regenerated decellularized adipose derivative is a porous material, the porosity is greater than 90%, and the aperture is 50-200 [mu] m; the composition comprises the following components in percentage by weight: 60-70% of collagen, 15-20% of elastin, 1 * 10 < 10 >-5 * 10 < 10 > particles / g of exosome, less than or equal to 5 ng / mg of DNA (deoxyribonucleic acid) residue, more than or equal to 30 ng / g of VEGF (vascular endothelial growth factor) and more than or equal to 15 ng / g of FGF-2 (fibroblast growth factor). The prepared regenerated decellularized adipose derivative is low in DNA residual quantity, rich in growth factors and capable of meeting the requirement for deep tissue filling due to the fact that the collagen content and the elastin content are high.

The invention relates to genetically encoded fusion proteins comprised of a capture component that binds a target with high affinity and a peptide polymer, such as elastin-like polypeptides, that display phase behavior and can be used for purification. The invention further relates to methods for optimizing capture fusion proteins for individual biologic targets such that phase separation occurs under desirable conditions, such as at room temperature, lower concentrations of salt, and / or at suitable pH ranges and optimized capture domains and polypeptides with phase behavior that have been identified by the optimization methods.

The present invention relates to the fields of medicine and cosmetology, and discloses a cell active peptide composition that promotes the regeneration of multi-type collagen structural proteins, its preparation method, and its application in medicine and cosmetology. The composition uses raw materials such as tripeptide-10 citrulline, hexapeptide-9, hydrolyzed sodium hyaluronate, γ-aminobutyric acid, decarboxylated carnosine hydrochloride, acetyl tetrapeptide-3, acetyl tetrapeptide-11, palmitoyl dipeptide-7, and palmitoyl pentapeptide-4. The composition can promote the coordinated expression of skin type I, type III, type IV, type VII, type XVII collagen, fibronectin, elastin, and glycosaminoglycans; prevent collagen cross-linking, maintain triple helix structure, and inhibit collagen degradation. Applied to dermatology and cosmetology, it can accelerate the regeneration of structural proteins such as skin collagen, repair skin damage, reduce wrinkles such as crow's feet, tear groove lines, nasolabial folds, and under-eye lines, solve the skin aging problem caused by the loss of structural proteins such as collagen, and improve skin elasticity and firmness.

The invention relates to a biomarker combination for clinical benefit of non-small cell lung cancer immunotherapy and application of the biomarker combination. The biomarker for predicting the clinical benefit of the non-small cell lung cancer immunotherapy comprises an immune globulin kappa light chain variable region 1-27 (IGKV1-27), a human leukocyte antigen H (HLA-H), an S100 calcium binding protein A8 (S100A8), a chromogranin A (CHGA), an elastin (ELN) and a nephronectin (NPNT). The biomarkers for predicting the clinical benefit of the immunotherapy of the non-small cell lung cancer can be detected, and the clinical benefit effect of the immunotherapy of the non-small cell lung cancer of a patient is judged by the markers.

The invention relates to the technical field of wound care, in particular to a responsive release microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, dissolving a polylactic acid-glycolic acid copolymer in an organic solvent, adding an emulsifier, and carrying out ultrasonic emulsification to form a water-in-oil emulsion; s2, mixing a polyphenol compound, elastin, vegetable fat and probiotic suspension to form a quaternary mixed solution, slowly dropwise adding the quaternary mixed solution into the water-in-oil emulsion, continuing ultrasonic emulsification to form multiple emulsion, and evaporating to remove an organic solvent to obtain a quaternary system active component mixed solution; and S3, dissolving PDMAEMA in deionized water, adding a cross-linking agent, stirring, slowly dropwise adding the quaternary system active component mixed solution, carrying out a cross-linking reaction, and freeze-drying to obtain the responsive release microcapsule. The microcapsule can accurately release corresponding active ingredients according to pH value changes in different stages of wound healing, effectively shorten the wound healing time, improve the healing quality and reduce scar formation.

The invention discloses an anti-aging and anti-wrinkle composition containing various polypeptides as well as a preparation method and application of the anti-aging and anti-wrinkle composition. According to the anti-aging and anti-wrinkle composition, various polypeptide components are compounded, a synergistic interaction system of the polypeptides is formed, acetyl hexapeptide-8 and snake venom-like peptide are taken as cores, and a dual inhibition pathway is established aiming at dynamic wrinkles; hexapeptide-9 and palmitoyl pentapeptide-4 are compounded to repair a matrix, and regeneration of corium layer structural protein is promoted; with the assistance of mu-conopeptide, palmitoyl tripeptide-1 and palmitoyl tripeptide-5, static wrinkle improvement and skin density improvement are enhanced; and finally, acetyl tetrapeptide-9 is assisted to activate elastin and optimize the contour supporting force, so that the synergistic effect of three effects of resisting wrinkles, tightening and repairing is realized, and the composition has more excellent inhibition rate of elastase and excellent free radical scavenging capacity, and achieves a remarkable antioxidant effect and an excellent anti-aging and anti-wrinkle effect.

The invention belongs to the technical field of protein expression, and particularly relates to recombinant elastin with repeated amino acid sequences and a preparation method thereof.The recombinant elastin is composed of 327 AA sequence units which are repeatedly connected in series twice and a spider silk protein GAAn module, and the AA sequence units are derived from human elastin containing VPGVG peptide fragment repeating units; the invention also discloses a double-repeat tandem sequence protein obtained by serially connecting AA sequence units twice, a coding gene of the double-repeat tandem sequence protein, a recombinant elastin sequence, a coding gene of the recombinant elastin sequence, a high-expression vector and a preparation method, and the problems of low protein expression efficiency and high purification cost at present are solved.

The present invention discloses a class of bicyclic peptide compounds and their applications, belonging to the technical field of bicyclic peptide compounds. Specifically, the invention relates to the preparation of a fully protected peptide resin using solid-phase synthesis; cleavage and monocyclic cyclization of the fully protected peptide resin to obtain a monocyclic polypeptide; and dicyclic cyclization of the monocyclic polypeptide to obtain a bicyclic peptide compound, wherein the dicyclic cyclization is carried out under the action of iodine methanol and ascorbic acid. The bicyclic peptide compound prepared by the present invention has the following beneficial effects: good safety, low cytotoxicity, good stability, slow degradation rate, good effect on enhancing collagen expression, good effect on enhancing elastin expression, and good effect on inhibiting neurotransmitter release.

The invention relates to an anti-wrinkle and anti-aging composition and application thereof. The anti-wrinkle and anti-aging composition is prepared from hydrolyzed rice protein, a bifidus yeast fermentation product lysate, dipeptide diaminobutyryl benzyl amide diacetate, adenosine, hydroxydecyl ubiquinone, ceramide NP, palmitoyl tripeptide-5, carnosine and acetyl hexapeptide-8. According to the present invention, the components achieve the synergistic effect, such that the fibroblast proliferation can be promoted, the cell metabolism can be improved, the generation of collagen, elastin and the like can be promoted, the excellent oxidation resistance can be provided, and the effects of expression line inhibition, existing wrinkle fading and long-term aging resistance can be combined.

An anti-aging composition for remodeling a dermal structure, a preparation method therefor and a use thereof, relating to the technical field of cosmetics. The anti-aging composition provided comprises the following components in parts by mass: 0.1-5 parts of an alpinia zerumbet leaf extract, 0.01-2 parts of a mixed solution of sodium mannose phosphate and mannose, and 0.01-0.2 parts of retinol substances. The composition provided can promote the generation of collagen and elastin in a reticular layer, enhance the cohesion, enable the reticular layer to have a more compact structure and fiber bundles to be more tightly woven, and promote fibroblast proliferation and metabolism to prevent the extracellular matrix from disintegration, thereby completing remodeling of the dermal structure, toughening the dermal-epidermal junction, and achieving the effect of lifting and firming the skin. The composition can also be prepared into an essence to achieve the effects of ameliorating skin dullness and repairing the skin barrier. The preparation methods for the anti-aging composition and the essence are simple, the raw materials are easily obtained, and the actual production is easy.

The invention relates to a recombinant elastin and a preparation method thereof as well as a recombinant elastin raw material and application thereof, and belongs to the technical field of recombinant proteins. The amino acid sequence of the recombinant elastin is an amino acid sequence as shown in SEQ ID No.1 or a derivative amino acid sequence of which the sequence identity with the SEQ ID No.1 is more than 90%. The protein is high in expression level, high in purity and relatively high in biological activity, and has the effects of supplementing skin collagen, resisting aging and repairing skin barriers.

The invention belongs to the technical field of cosmetics, and particularly relates to a natural-source composition with a function of inhibiting multiple types of matrix metalloproteinases of skin and application of the natural-source composition. The composition is prepared from the following components: herba cistanche powder, American ginseng powder, a red-knees herb extract and a creeping rostellularia herb extract. The composition has the effects of inhibiting expression of multiple types of matrix metalloproteinases in skin immortalized keratinocytes, improving elastin synthesis and inhibiting elastase decomposition, and has no obvious side effects. The composition disclosed by the invention can be used for preparing various cosmetics, functional foods and health-care products related to skin aging resistance, and has a wide application prospect.

The invention provides recombinant humanized elastin with an effect of improving endogenous skin aging and application of the recombinant humanized elastin, and belongs to the technical field of crossing of dermatology and biological materials. The recombinant humanized elastin is based on a human elastin core function sequence, recombinant optimization and efficient expression are carried out by adopting a synthetic biological strategy, and excellent stability and biological activity are shown. The recombinant humanized elastin can be used for constructing a skin repair dressing, and synergistically improves endogenous aging characteristics such as skin elasticity reduction, collagen loss and high oxidative stress by remodeling an extracellular matrix network structure. Animal experiments prove that a product based on the recombinant humanized elastin has good tissue repair capacity, biocompatibility and antioxidant activity, and can be widely applied to functional skin care products and medical cosmetic preparations.

The invention discloses a method for improving the texture characteristics of canned abalone. After fresh abalone is taken out, cleaned, water-controlled, shaped and salt-ground, composite protease is used to decompose collagen and elastin in the abalone meat and hydrolyze connective tissue fibers. At the same time, ultrasonic treatment is used to destroy the original muscle structure, which effectively reduces the hardness value of the abalone meat. After the treatment, the abalone meat is cleaned, water-controlled, blanched, tooth-removed and graded, and then placed in a 500V DENBA+ electrostatic wave preservation system and treated at 4°C for 1h. After that, the abalone meat is subjected to metal detection, weighing and canning, vacuum sealing, can washing, sterilization and cooling, and drying. The canned abalone treated by the above steps can improve its rubber meat texture characteristics to the greatest extent, effectively ensure the moisture of the abalone meat, and maintain its nutritional components, good flavor and taste.

The invention discloses a molecular chaperone synergistic blue-copper peptide and application thereof, belongs to the technical field of skin care, and particularly relates to a blue-copper peptide composition formed by compounding blue-copper peptide and N-acetylneuraminic acid, and the structure of the blue-copper peptide is that copper is connected to glycyl-L-histidyl-L-lysine; the blue copper peptide and the N-acetylneuraminic acid are mixed according to the mass ratio of 1: (0.1-1) for use, and further, phenylalanine derivatives can be added into the mixture for compounding. When the blue copper peptide composition obtained by the invention is applied to cells, the cell survival rate is high, the non-enzymatic glycosylation inhibition rate is good, and the expression of Elastin, Col-I and Col-IV mRNA in the cells is high. Therefore, the blue copper peptide composition disclosed by the invention is high in cell survival rate, good in non-enzymatic glycosylation inhibition rate and capable of improving the mRNA expression of Elastin, Col-I and Col-IV in cells, and the application of the blue copper peptide composition.

The invention provides a preparation method of injection polylactic acid microspheres, and relates to the technical field of medical cosmetology, and the preparation method comprises the following steps: preparing an organic solution of polylactic acid; preparing an aqueous solution of recombinant elastin, recombinant collagen and sodium carboxymethyl cellulose; dropwise adding the organic solution of polylactic acid into the aqueous solution of recombinant elastin / recombinant collagen / sodium carboxymethyl cellulose, uniformly mixing, and then removing the organic solvent in the mixed solution; and carrying out freeze-drying treatment on the obtained solution to obtain the injectable polylactic acid microspheres. The recombinant elastin and the recombinant collagen are added, so that a spongy fiber structure can be formed after a final freeze-drying process, the freeze-dried mixture is easy to redissolve, and the polylactic acid microspheres can be uniformly dispersed in a solution; moreover, the recombinant elastin and the recombinant collagen which are added in the invention not only have the effects of moisturizing and replenishing water and improving the skin state, but also have the lubricating effect and can reduce the resistance during injection, so that the problem that the injection of the polylactic acid microspheres needs larger injection force is solved, and the dosage during injection is more easily and accurately controlled.

The present invention relates to a recombinant human elastin protein, and its preparation method and application. The recombinant human elastin protein comprises one or more elastin domains in the amino acid sequence of the full-length human elastin protein as shown in SEQ ID NO.1, as well as one or more of a secretion tag, a histidine tag, a fluorescent protein, and a protease cleavage site. The amino acid sequence of the recombinant human elastin protein is shown in SEQ ID NO.2. The nucleotide sequence is a recombinant plasmid, a recombinant vector, or a recombinant bacterium. The preparation method comprises: synthesizing the nucleotide sequence as shown in SEQ ID NO.1, constructing a recombinant protein, inducing expression, centrifuging, purifying, and drying to obtain the recombinant human elastin protein as shown in SEQ ID NO.2. The application is to detect and evaluate the anti-aging, anti-wrinkle, and firming effects of the recombinant human elastin protein, as well as in cosmetics. The preparation method of the present invention is simple, the protein expression level is high, and the cosmetic product has anti-aging, anti-wrinkle, and firming effects.

The invention discloses a method for purifying recombinant protein. The framework of the fusion protein is characterized in that a series tag consisting of elastin-like protein (ELP) and SUMO is connected with a target protein. The fusion protein is purified by utilizing the reversible phase change cycle (ITC) property of ELP, and the separation and purification of the recombinant protein can be realized only through simple centrifugal operation, so that the fusion protein with higher purity is obtained, and the required recombinant target protein can be obtained subsequently through enzyme digestion and ITC. The technology is wide in application range, simple and convenient in purification method, low in cost and suitable for industrial amplification, and has a good commercial prospect.

The invention provides an extracellular matrix protein recombinant protein, a nucleic acid molecule, a recombinant vector, a genetically engineered bacterium, a preparation method and an application. The provided extracellular matrix protein recombinant protein comprises the following protein fragments: human fibronectin, humanized collagen and elastin-like protein. Wherein the amino acid sequence of the human fibronectin is as shown in SEQ ID NO. 1; the amino acid sequence of the humanized collagen is as shown in SEQ ID NO. 2; the elastin-like protein comprises a pentapeptide repetitive sequence, repetitive units of the pentapeptide repetitive sequence comprise-[valine-proline-glycine-Xaa-glycine] n-, Xaa is isoleucine or lysine, and the number n of the repetitive units is 15-30; in the extracellular matrix protein recombinant protein, any two adjacent ones of the human fibronectin, the humanized collagen and the elastin-like protein are independently connected through a peptide bond or a connecting peptide. The extracellular matrix recombinant fusion protein provided by the invention has good thermal stability and can promote cell adhesion.

The invention discloses a multi-functional domain fusion extracellular matrix protein as well as a coding gene, a preparation method and application thereof, and belongs to the fields of biotechnology, medical cosmetology and wound repair. The multi-functional-domain fusion extracellular matrix protein provided by the invention contains core functional domains of human-derived III-type collagen, elastin and fibronectin, integrates key biological functions of the human III-type collagen, elastin and fibronectin, and is obtained by expression of mammalian cells. The method can promote formation of a collagen triple helix structure, is simple in process, high in yield and easy for industrial production, and can be widely applied to the fields of effective skin care, skin aging resistance, medical cosmetology, wound repair and the like.