828 results about "Skin repair" patented technology

The invention relates to the field of microorganisms, in particular to bifidobacterium adolescentis YG3912, inactivated thalli, an extract, a culture, a culture supernatant, a fermentation product and / or a fermentation supernatant of the bifidobacterium adolescentis YG3912, an application of the bifidobacterium adolescentis YG3912 in preparation of a composition for promoting skin repair, reducing skin inflammation or allergy, improving skin quality and improving skin quality. The invention also relates to application of the composition in products for resisting skin aging and enhancing skin immune function. The bifidobacterium adolescentis YG3912 and the related products thereof have the advantages that the bifidobacterium adolescentis YG3912 and the related products of the bifidobacterium adolescentis YG3912 are high in skin cell repairing capacity, skin inflammation relieving, inhibiting or eliminating capacity and remarkable in skin aging resisting capacity, so that the bifidobacterium adolescentis YG3912 and the related products of the bifidobacterium adolescentis YG3912 are expected to be used for skin health care such as skin repairing, inflammation relieving and light aging resisting, and the bifidobacterium adolescentis YG3912 and the related products thereof have remarkable application value and market potential.

The invention discloses hip cream as well as a preparation method and application thereof, and belongs to the technical field of infant care products. The hip cream comprises a phase A, a phase B and a phase C, wherein the phase A comprises caprylic capric triglyceride, olive oil, camellia-seed oil, cera alba, sunflower seed oil and white ozocerite; a phase B: trihydroxy stearin; a phase C: VE acetate, folium artemisiae argyi essential oil, Roman chamomile, tea tree oil and double purple oil; and phase D: simmondsia chinensis seed oil. According to the invention, by optimizing the components and dosage in the hip cream, the prepared hip cream has good anti-inflammatory, soothing, moisturizing and skin repairing effects, the problems of red buttocks of newborns and skin ulceration, water loss, chapping, desquamation and the like caused by the red buttocks of the newborns are reduced, and meanwhile, the use of medicaments such as erythromycin ointment and the like is reduced. Meanwhile, the surface of the paper diaper can be coated with the hip cream to obtain the paper diaper containing the hip cream coating, the repairing and other effects of the hip cream are utilized, meanwhile, the paper diaper containing the hip cream has better soft feeling and smooth feeling, and damage caused by friction of the paper diaper is reduced.

The invention relates to an anti-aging oligopeptide for beauty and skin care, the oligopeptide has an amino acid sequence as shown in (X1) (R or K or H) G (D or E) # (X2), X1 represents one amino acid of G, A, V, L, I and P or represents that no amino acid exists, # represents one amino acid selected from A, V, D, E, N and Q, and X2 represents G and P or represents that no amino acid exists. The oligopeptide is a functional fragment of XVII type collagen, can induce in-vivo collagen synthesis or simulate a protein regulation function, has the effects of promoting cell self-cleaning, helping to remove aged skin cells, reconstructing skin rhythm, maintaining a good skin structure, resisting initial aging, promoting skin repair and regeneration, reducing fine wrinkles and the like, and is mild in action, free of side effects and free of toxic and side effects. The product has no obvious adverse reaction on human body, and is a good beautifying and anti-aging product.

The invention discloses a recombinant XVII type collagen engineering bacterium as well as a preparation method and application thereof, and belongs to the technical field of genetic engineering, and the recombinant XVII type collagen engineering bacterium is realized through three steps of designing and optimizing collagen, improving translation through codon optimization and selecting a vector for cloning. By optimizing the amino acid sequence and the codon, the expression efficiency and the stability of the recombinant XVII type collagen in engineering bacteria are improved. The optimization not only improves the production efficiency of the protein, but also reduces the production cost. The recombinant XVII type collagen has potential in the medical field, especially in the fields of skin repair, wound healing, aging resistance and the like. Meanwhile, in the fields of beauty and biological materials, collagen is widely applied to products such as masks and skin care products as a basic component, and can promote skin cell regeneration and enhance skin elasticity and repair capacity.

The invention belongs to the field of synthetic biology, and particularly relates to collagen fusion polypeptide as well as application and a preparation method thereof. The collagen fusion polypeptide provided by the invention comprises: (a) a first polypeptide of recombinant III-type collagen; and (b) a second polypeptide comprising a trimerized folding domain. The collagen fusion polypeptide provided by the invention has the advantages of low immunogenicity, good biocompatibility, high biological activity and the like, can significantly promote proliferation and migration of human skin fibroblasts, and has stronger ability of promoting regeneration of endogenous collagen. The collagen fusion polypeptide has a triple helix structure similar to natural collagen, and can be self-assembled to form collagenous fibers which are good in morphology and similar to natural collagen. The method can be widely applied to the fields of skin repair dressings, biological materials, artificial implants, medical instruments, cosmetics, health care products, food and the like.

The invention provides a novel human-derived II-type collagen COLII-14K-H and a coding gene thereof, the coding gene is shown as SEQ ID NO.1, and the amino acid sequence is shown as SEQ ID NO.2. The invention further provides a preparation method of the novel human-derived II-type collagen COLII-14K-H. The invention also provides a preparation method of the human-derived II-type collagen COLII-14K-H and application of the human-derived II-type collagen COLII-14K-H in preparation of cartilage repair drugs, skin repair drugs and skin care products. The inventor-derived II-type collagen can obviously improve the gene expression level of the collagen, so that the content of the collagen in human dermal fibroblasts is improved, and the skin aging is delayed; meanwhile, the protein fragment can show a remarkable skin repairing effect at low concentration, provides a new treatment choice for skin repairing, and can be widely applied to the fields of skin repairing and nursing.

The invention relates to a eutectic microcapsule wrapping technology and application thereof in cosmetics, and belongs to the technical field of cosmetic production. The wall material of the eutectic microcapsule inclusion comprises at least one of hydrogenated lecithin, caprylic / capric triglyceride, sucrose stearate, PEG-8 caprylic / capric glycerides, PEG-40 hydrogenated castor oil, soya bean lecithin, cyclodextrin, ethyl palmitate and troxerutin. The core material is prepared from at least one of salicylic acid, 4-butylresorcinol, glabridin, a kava extract, cortex magnoliae officinalis total phenols, ginseng oil, ganoderma lucidum spore oil, astaxanthin, coenzyme Q-10, a rosemary extract, ceramide and vitamin E. According to the invention, multiple eutectic coating can be formed, the consumption of the wall material can be reduced, the cost is saved, the wall material and the core material are matched for use, so that the excellent effects of permeation, oxidation resistance, soothing, allergy resistance and skin repair can be achieved, and the utilization rate of active substances is increased.

The invention provides a recombinant humanized elastin with high biological activity as well as a preparation method and application thereof, and belongs to the technical field of genetic engineering and biological materials. 100% of the amino acid sequence of the elastin is derived from human elastin and is prepared by expression of genetically engineered bacteria; the protein has a typical beta-spiral hydrophobic structural domain and a lysine-rich hydrophilic structural domain, has a good bionic structure and functional characteristics, can significantly promote proliferation, adhesion and migration of human skin fibroblasts, also has excellent antioxidant, anti-wrinkle and anti-aging activities, and can be used for preparing a biomimetic protein. The hydrogel can be widely applied to the fields of skin repair dressings, injection implants, artificial skin, biomedical materials, functional skin care products and the like; in addition, the elastin is good in solubility, high in stability, mature in expression system and suitable for large-scale production.

The invention discloses a natural vegetable oil composition as well as a preparation method and application thereof. The natural vegetable oil composition comprises sunflower seed oil, simmondsia chinensis seed oil, grape seed oil and camellia seed oil. The feeding mass ratio of the sunflower seed oil to the simmondsia chinensis seed oil to the grape seed oil to the camellia seed oil is 1: (0.5-1.5): (0.5-1.5): (0.5-1.5); the components are uniformly mixed during preparation, practice shows that the combination of the four natural plant-derived oils has an excellent moisturizing effect and a skin repairing effect and has a remarkably better and more balanced effect compared with a single or partial combination of the four natural plant-derived oils, and particularly, the remarkable moisturizing and skin repairing effects can be obtained only by a small addition amount; the composition is beneficial to addition and use in cosmetics, does not need to adopt excessive emulsifiers for additional emulsification and dispersion, is beneficial to reduction of irritation brought by the emulsifiers, and is good in use experience.

The invention relates to a double-layer dressing for promoting wound healing and inhibiting scars and a preparation method and application thereof.The double-layer dressing comprises a hydrogel layer and a piezoelectric film layer compounded on the hydrogel layer, and the piezoelectric film layer is prepared by mixing an organic piezoelectric material, a ferroelectric material and an organic solvent and then conducting an electrostatic spinning technology; the hydrogel layer is formed by curing a methacrylic anhydride acellular extracellular matrix, methacrylic anhydride catechol chitosan and conductive nanoparticles under the action of a curing agent. The lower skin contact layer of the double-layer dressing is the hydrogel layer, so that the directional growth of fibroblasts is favorably induced; the upper dressing is a piezoelectric material composite ferroelectric material, is beneficial to piezoelectric stimulation re-induction function recovery after final skin repair and guidance of directional growth of wound cells, and has good skin wound induction repair and scar inhibition effects.

The invention discloses a shell nacre-derived anti-inflammatory active peptide and application thereof in preparation of a skin repair product. The inhibition rate of the active peptide GEIRYEYF provided by the invention on the NO release amount is concentration-dependent, and the NO release amount is reduced by 54.32 + / -2.13% under the concentration of 200 mu g / mL; in addition, secretion of RAW264.7 macrophage pro-inflammatory cytokines TNF-alpha and IL-6 can be remarkably reduced, secretion of anti-inflammatory cytokines IL-10 can be improved, dose dependence is achieved, under the highest concentration, the influence on IL-6 secretion is 47.76 + / -1.02%, the influence on TNF-alpha secretion is 42.01 + / -4.64%, the influence on IL-10 secretion is 41.71 + / -1.67%, and good anti-inflammatory activity is achieved. In addition, the bioactive peptide has a remarkable proliferation effect on L929 cells, and it is indicated that the bioactive peptide has the potential of promoting skin wound healing.

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning and / or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

The invention discloses a medical sodium hyaluronate skin repair gel and a preparation method thereof, and mainly relates to the technical field of hyaluronic acid, the medical sodium hyaluronate skin repair gel comprises the following components: sodium hyaluronate, a synergist, glycerol, carbomer, 1, 3-butanediol, triethanolamine and water. Compared with the prior art, the medical sodium hyaluronate skin repair gel prepared by the invention can relieve erythema, pruritus and other symptoms caused by skin inflammation; the wound dressing can also be used for nursing non-chronic wounds, such as superficial wounds, sutured wounds after operations, mechanical wounds and the like; meanwhile, a bacteriostatic environment for wound healing is kept, and skin repair is accelerated; the scar hyperplasia phenomenon in the skin wound repairing process is reduced.

Provided are a madecassoside composition with a skin repair effect and use thereof. A scratch experiment demonstrated that madecassoside derivatives I and II have good effects in promoting the closure of the intercellular gaps between human keratinocytes. A subsequent transdermal experiment and an assay of skin repair-related factor expression found that the efficacy can be potentially enhanced by compounding the madecassoside derivatives I and II. Formulations were then screened for optimal acne-removing effects in an efficacy study in humans. Finally, the safety and applicability of the derivatives as cosmetic starting materials were verified in a safety study. The studies on madecassoside derivatives facilitate the application and development of Centella asiatica in acne-removing cosmetics.

The invention provides recombinant IV type collagen and application thereof, and relates to the technical field of protein engineering. In the invention, an amino acid residue repetitive unit with good biological activity and stability in the human-derived IV-type collagen is found, and the amino acid residue repetitive unit is used as a core for repeating and constructing the recombinant IV-type collagen, so that the novel human-derived recombinant IV-type collagen with biological activity is obtained. The human-derived recombinant IV-type collagen provided by the invention is a small-molecular-weight protein, is easy to absorb by a human body, is good in safety, can remarkably promote secretion of collagen, also has the effects of promoting cell adhesion and cell migration, and has a good application prospect in the aspects of basement membrane repair and remodeling. A new functional component is provided for products for repairing and tightening the skin, resisting aging, resisting wrinkles, preserving moisture and the like.

The invention belongs to the technical field of regenerated medical dressings, particularly relates to a plant polysaccharide hydrogel medical dressing for promoting tissue damage repair and application thereof, and provides the following scheme that a medical and mechanical combined product comprises a regenerated medical dressing and a low-temperature sterile storage box for storing the regenerated medical dressing, the regenerated medical dressing comprises a hydrogel main body, open pores formed in the hydrogel main body, sustained-release vesicles arranged in the open pores, and stem cells and a cell culture medium which are filled in the sustained-release vesicles. The stem cell hydrogel can rapidly break blood, rapidly stop bleeding by being attached to a wound surface and promote wound closing, stem cells are inoculated to the upper surface of the hydrogel formed by dendrobium polysaccharides, aloe, lily, coptis chinensis and honeysuckle, safe application of the stem cells is achieved, active factors secreted by the stem cells are slowly released to the skin wound surface, and the wound healing effect is achieved. Through contact stimulation between cells, various cytokines can be secreted better, and the skin repair efficiency is improved.

The invention provides a gel dressing and a preparation method thereof, and belongs to the technical field of medical materials.The gel dressing comprises a basement membrane which is a PVA membrane; the gel layer is arranged on the surface of the basement membrane, and the gel layer is prepared from recombinant collagen, exosome, sodium hyaluronate, sodium carboxymethyl cellulose, chitosan and water; the microneedles are evenly arranged on the side, away from the basement membrane, of the gel layer, the microneedles are made of polylactic acid-hydroxy acid copolymer, and the needle tips of the microneedles are loaded with recombinant collagen and exosomes. A skin channel is opened through the microneedle array, the permeation efficiency of recombinant collagen and exosome is improved by multiple times, a large number of active ingredients can quickly reach the deep layer of the skin, and the skin repairing effect is remarkably enhanced.

According to the fermentation filtrate with the anti-wrinkle effect and the preparation method, purely natural rice or brown rice is gelatinized to form a natural culture medium, so that the use of a synthetic culture medium and a chemical reagent is completely avoided, and a purely natural daily chemical care raw material without chemical residues can be obtained; rhizopus and fermentation brightening factors are subjected to mixed fermentation. The method has the technical advantages that the mixed bacteria are fermented at the same time, additional step-by-step fermentation culture is not needed, fermentation product filtrate without obvious ethanol can be obtained, the filtrate can remarkably improve the content of active ingredients such as exopolysaccharides, small molecule peptides and organic acids, and the obtained fermentation liquor has a remarkable improvement effect on skin inflammation repair.

The invention discloses a double-structural-domain recombinant human fibronectin, the sequence of which is shown as SEQ ID NO.3, and the double-structural-domain recombinant human fibronectin is formed by fusing a collagen binding structural domain and a cell binding structural domain of human fibronectin. The invention also provides a recombinant expression vector containing the protein coding gene and a host cell. The protein is efficiently expressed through eukaryotic cells and engineering bacteria escherichia coli, and a fermentation and purification process suitable for an industrial scale is established in a matched manner. Functional experiments prove that compared with commercially available fibronectin products with a single structural domain, the double-structural domain recombinant human chemical fibronectin disclosed by the invention can remarkably promote proliferation, migration, adhesion and differentiation activity of human skin fibroblasts, and has wide application potential in the fields of skin repair, skincare and biomedical materials.

The invention relates to the field of microorganisms, and discloses lactobacillus rhamnosus and application thereof. The lactobacillus rhamnosus with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.33153, provided by the invention, has relatively strong reproductive capacity, can produce lactic acid and hydrogen peroxide at high yield, and has relatively strong antibacterial performance; the polypeptide has the potential of being applied to organisms; the composition can regulate and control inflammation and apoptosis related genes, so that the generation amount of inflammatory factors is reduced, cell growth and repair are promoted, and gene expression of aquaporin and collagen can be up-regulated, so that skin repair is promoted.

A composition capable of resisting inflammation and promoting skin repair, includes platelet-rich plasma(PRP) and further includes β-nicotinamide mononucleotide(NMN) and sialic acid(NANA). The composition can significantly accelerate wound healing. Compared with separate use of the platelet-rich plasma, the NMN or the sialic acid,the composition promotes faster wound healing. Moreover, after wound scar repair, the resulting scar appears lighter in color.

The invention belongs to the technical field of gene engineering, and discloses soluble recombinant triple helix III type collagen, a preparation method and application, the amino acid sequence of the recombinant triple helix III type collagen is shown as SEQ ID No.1, compared with animal source III type collagen, the recombinant triple helix III type collagen is single in component, high in purity, small in batch-to-batch difference, free of immunogenicity, free of virus transmission and other hidden dangers; the constructed escherichia coli of the Sumo-III type collagen is short in culture period, the expression quantity of the III type collagen is high, and inclusion bodies are not easy to form; the water solubility is good, and the quality is stable; a Gly-X-Y repeated amino acid sequence mode is strictly obeyed, and the disease risk caused by mutation does not exist; and the three-helix structure can be widely applied to the fields of skin care products, skin repair dressings, implants, artificial skin, biological materials, medical instruments, health food and the like.

The invention relates to application of Bergapten or an isomer thereof in preparation of a product for improving skin aging and / or promoting skin repair. A large number of experiments prove that Bergapten or an isomer thereof can improve skin aging and / or promote skin repair and has good safety, and the specific expression is as follows: Bergapten can activate expression of SIRT1 protein and is superior to that of an existing activator resveratrol; the Bergapten can obviously inhibit the reduction of the content of various collagens in skin keratinocytes caused by UV light aging stimulation; the Bergapten can be used for promoting the healing capability of cell scratches. In conclusion, the Bergapten or the isomer thereof has great clinical application prospect and value in preparation of products for improving skin aging and / or promoting skin repair.

The invention relates to an artificially synthesized no-load exosome capable of promoting permeation and having a repairing effect as well as a preparation method and application of the artificially synthesized no-load exosome, and belongs to the technical field of cosmetics and biology. The artificially synthesized no-load exosome comprises a membrane core structure, the membrane structure of the artificially synthesized exosome comprises hydrogenated lecithin, phytosphingosine, cholesterol, ceramide, squalane, sodium stearoyl glutamate and a surface modification structure, and the core of the artificially synthesized exosome comprises water. The artificially synthesized no-load exosome provided by the invention has good particle size uniformity, particle size stability, permeation enhancing performance, permeation enhancing effect stability and skin repairing effect.

The invention discloses an antibacterial dressing for skin repair and a preparation method thereof, and relates to the field of medical dressings. The antibacterial dressing for skin repair is prepared from the following raw materials in parts by weight: 4-8 parts of carboxymethyl chitosan, 2-5 parts of collagen, 5-10 parts of glycerol, 10-20 parts of a framework material, 1-2 parts of an antibacterial agent, 1-3 parts of a humectant and 70 parts of purified water. The prepared antibacterial dressing for skin repair has good moisturizing performance and antibacterial performance.

The invention relates to the technical field of cosmetics, in particular to a product containing flexible glucan, which can be prepared by treating materials containing glucan by adopting high-pressure microjet. According to the product containing the flexible dextran, the flexible dextran has a special intramolecular and intermolecular arrangement mode, has excellent effects of promoting wound healing and resisting inflammation, has an outstanding effect of promoting skin repair after being added into cosmetics, can effectively improve the after-healing effect of dot matrix laser, acid brushing, microneedle and other medical beauty projects, and has a good application prospect. Meanwhile, the repair of sensitive skin can be promoted. According to the preparation method of the product containing the flexible glucan, the intramolecular and intermolecular arrangement form of the glucan can be adjusted, the flexibility of the product is improved, meanwhile, the room-temperature stability of the product is improved, and the product can be massively added into cosmetics.

The utility model relates to the technical field of equipment for skin care products, in particular to a skin repair lotion mixing device which comprises a base and a fixing seat mounted on the base, a mixing pipe used for containing cosmetic raw materials is mounted on the fixing seat, the mixing pipe is rotationally arranged on the fixing seat, and the mixing pipe is connected with the fixing seat. And a driving device for driving the mixing pipe to rotate is arranged on the fixed seat. The problems of non-uniform mixing and low mixing efficiency of the skin care lotion are solved.

The present invention discloses the preparation of an anti-inflammatory peptide derived from the hydrolysis of shell nacre protein and its application in skin repair. The peptide PDFDNGF provided by the invention can effectively promote the proliferation of RAW264.7 macrophage cells and inhibit the excessive production of nitric oxide and cytokines in RAW264.7 cells induced by lipopolysaccharide, while increasing the levels of anti-inflammatory cytokines, demonstrating significant anti-inflammatory activity. Furthermore, the active peptide has a significant proliferative effect on L929 cells, indicating its potential to promote skin wound healing. This invention provides a theoretical basis for the high-value utilization of shell nacre.

The invention relates to a natural plant composition for treating acne and application thereof. The composition comprises a scutellaria baicalensis extract, a fructus cnidii extract, a herba violae extract, a mangnolia officinalis extract, a Chinese herbaceous peony extract, a radix ophiopogonis extract, a silybum marianum extract and a gastrodia elata extract. The formula is designed according to the traditional Chinese medicine compatibility theory, and the composition formula has a synergistic effect and can effectively inhibit growth of propionibacterium acnes, reduce skin inflammation and generation of erythema and acne marks after acnes, promote fading of the acnes and skin repair and effectively treat the acnes. The composition is stable in formula quality, safe and free of skin irritation, provides a new thought for acne treatment and skin repair, and has a good market application prospect.

The invention belongs to the technical field of cosmetics, and discloses a composition for relieving redness and inflammatory color deposition as well as a preparation method and application of the composition. The composition comprises the following components: a plant extract and a derivative thereof, zinc salt, a resorcinol derivative and protein, the plant extract and the derivative thereof comprise at least one of an artemisia apiacea extract and a derivative thereof, and a glycyrrhiza inflate extract. The artemisia apiacea extract and the derivative thereof and / or the glycyrrhiza inflate extract, the zinc salt, the resorcinol derivative and the protein are reasonably compounded, so that red, swollen and discomfort in the inflammation period can be relieved, repair of damaged skin can be promoted, color sink after inflammation can be reduced, and scar generation can be inhibited; meanwhile, the composition is mild and non-irritant, and is suitable for sensitive skin and damaged skin.