172 results about "Erythema" patented technology

The embodiment of the invention provides a multi-modal data fused postoperative plastic surgery infection early warning method and system. The method comprises the following steps: firstly, performing quality evaluation and restoration on postoperative wound images, clinical texts, wearable vital signs and baseline features; performing double-flow coding and priori segmentation on the repaired image to obtain a coarse mask; constructing a super-pixel graph, obtaining a topological consistent fine mask through a graph neural network, and quantifying the erythema / exudation area; the text and the vital signs are coded respectively and then fused with the image features and the masks through cross-attention and self-attention, and a fusion implicit vector and uncertainty are obtained through quality weight gating; an individualized dynamic threshold value is constructed by combining baseline risk, logarithmic probability calibration and a sliding window trend, a confidence band is output by using conformal prediction, and early reliable infection early warning is realized.

The invention belongs to the field of burn grading, and particularly relates to a burn grading detection method based on three-dimensional reconstruction, and the method comprises the steps of depth inspection, human body three-dimensional modeling, model compression, curved surface labeling, burn surface area calculation and burn indexing. According to the scheme, the semantic segmentation network used for dividing the burn area is constructed, the semantic segmentation network is accelerated by utilizing FPGA hardware, a network model is compressed by adopting a pruning method, and the FPGA hardware storage and calculation pressure is reduced; according to the method, two thresholds of HSV and CIELAB color spaces are combined, erythema recognition specificity is improved, blister morphological characteristics are quantified through edge detection, convex hull defect analysis and brightness variance, voice content keywords and acoustic emotion characteristics are fused, patient pain is quantified, and an automatic complete solution is provided for burn indexing through three-dimensional reconstruction and space mapping. And the defects of traditional subjective diagnosis are overcome.

Pet food compositions, and particularly, pet food compositions comprising fish collagen hydrolysate are disclosed herein. Also disclosed herein are methods of treating an immune disorder, such as atopic dermatitis in a companion animal in need thereof and methods of alleviating at least one of pruritus, erythema, or alopecia in a companion animal with atopic dermatitis.

The invention discloses a medical sodium hyaluronate skin repair gel and a preparation method thereof, and mainly relates to the technical field of hyaluronic acid, the medical sodium hyaluronate skin repair gel comprises the following components: sodium hyaluronate, a synergist, glycerol, carbomer, 1, 3-butanediol, triethanolamine and water. Compared with the prior art, the medical sodium hyaluronate skin repair gel prepared by the invention can relieve erythema, pruritus and other symptoms caused by skin inflammation; the wound dressing can also be used for nursing non-chronic wounds, such as superficial wounds, sutured wounds after operations, mechanical wounds and the like; meanwhile, a bacteriostatic environment for wound healing is kept, and skin repair is accelerated; the scar hyperplasia phenomenon in the skin wound repairing process is reduced.

The invention discloses a barrier repair composition applicable to dry sensitive skin and application thereof. The composition comprises a golden camellia extract, a loquat leaf extract, an alfalfa extract and hydrolyzed royal jelly protein. According to the barrier repairing composition applicable to the dry sensitive skin, disclosed by the invention, through reasonable matching and synergistic interaction of all the components, a better skin barrier repairing effect can be achieved, so that the problems of dry and tight skin, desquamation, erythema, itching, dull luster, redness, burning heat sensation, pricking pain and the like of the dry sensitive skin are fundamentally solved.

The invention discloses an application of core proteoglycan or a coding gene thereof as a target spot in preparation of psoriasis treatment drugs, and a series of experiments prove that DCN can effectively protect mouse psoriasis-like dermatitis induced by imiquimod, improve skin scale, erythema, thickening and epidermal abnormal differentiation, enhance the barrier function of skin, improve the curative effect of psoriasis, and improve the curative effect of psoriasis. A large amount of infiltration of inflammatory cells is reduced, and a certain anti-inflammatory effect is achieved. Experimental research shows that the DCN has an obvious drug effect on a psoriasis model, is safe and efficient, has no side effect, is simple in production process and has the potential of realizing medical transformation. And the potential application value of the DCN on other various skin inflammatory diseases can be expanded.

The invention relates to a natural plant composition for treating acne and application thereof. The composition comprises a scutellaria baicalensis extract, a fructus cnidii extract, a herba violae extract, a mangnolia officinalis extract, a Chinese herbaceous peony extract, a radix ophiopogonis extract, a silybum marianum extract and a gastrodia elata extract. The formula is designed according to the traditional Chinese medicine compatibility theory, and the composition formula has a synergistic effect and can effectively inhibit growth of propionibacterium acnes, reduce skin inflammation and generation of erythema and acne marks after acnes, promote fading of the acnes and skin repair and effectively treat the acnes. The composition is stable in formula quality, safe and free of skin irritation, provides a new thought for acne treatment and skin repair, and has a good market application prospect.

The invention discloses application of tea extracellular vesicles in preparation of a product for preventing and / or treating UVB-induced skin photoaging, and belongs to the technical field of application of the tea extracellular vesicles. The tea extracellular vesicles are derived from tea leaves and / or stem leaves and are prepared by a method of combining enzymolysis, multi-stage filtration and ultracentrifugation, and the particle size of the tea extracellular vesicles is mainly distributed in a range of 60-100nm. Experiments show that the tea extracellular vesicles can effectively reduce active oxygen accumulation and lipid peroxidation caused by UVB radiation, repair mitochondrial membrane potential and inhibit expression of matrix metalloproteinase and inflammatory factors, so that photoaging symptoms such as skin wrinkles, erythema and barrier function damage are relieved. The tea extracellular vesicle provided by the invention has the advantages of natural raw materials, good biocompatibility, small side effect and the like, can be used for preparing a plurality of external dosage forms such as gel, cream, spray and the like, and provides a safe and effective new natural product choice for prevention and treatment of skin photoaging.

Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to CD38, are capable of killing CD38′ cells by apoptosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and / or complement-dependent cytotoxicity (CDC). Said antibodies and fragments thereof may be used in the treatment of tumors that express CD38 protein, such as multiple myeloma, chronic lymphocytic leukemia, chronic myelogenous leukemia, acute myelogenous leukemia, or acute lymphocytic leukemia, or the treatment of autoimmune and inflammatory diseases such as systemic lupus, rheumatoid arthritis, multiple sclerosis, erythematosus, and asthma. Said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of CD38. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CD38 protein.

The invention discloses application of METTL1 as a target spot in preparation of a medicine for treating erythema squamous skin diseases, relates to the field of biological medicines, provides a new scheme for treatment of erythema squamous skin diseases, especially psoriasis and atopic dermatitis, relieves inflammatory response of psoriasis or atopic dermatitis by inhibiting expression of METTL1, and provides a new application of METTL1 as a target spot in preparation of medicines for treating erythema squamous skin diseases, especially psoriasis and atopic dermatitis. And erythema, scales and skin thickness are reduced.

Provided are an antibacterial and deodorizing composition and a functional core prepared from the composition. The antibacterial and deodorizing composition comprises the following components in parts by mass: 10%-30% of a wormwood extract, 5%-30% of a grapefruit extract, 5%-20% of a haematococcus pluvialis extract, 5%-20% of citronellyl methylcrotonate, and the balance of a solvent. The antibacterial and deodorizing composition disclosed in the present invention not only exhibits broad-spectrum antibacterial and bactericidal effects on various microorganisms and thereby prevents symptoms such as allergy, inflammation, and erythema, but also can chelate substances such as amine, ammonia gas, and hydrogen sulfide in urine and demonstrate odor-masking effect, and thereby can effectively eliminate the odor of urine.

The invention relates to a pharmaceutical composition, which is prepared from adapalene, benzoyl peroxide, a traditional Chinese medicine extract, an acrylamide and acryloyl dimethyl sodium taurate copolymer, a mixture of isohexadecane and polysorbate 80, docusate sodium, EDTA (Ethylene Diamine Tetraacetic Acid) disodium, glycerol, poloxamer 124, propylene glycol and water, the traditional Chinese medicine extract comprises moutan bark, salvia miltiorrhiza, radix rehmanniae recen, radix sophorae flavescentis, coptis chinensis, rheum officinale, scutellaria baicalensis, menthol and borneol. According to the pharmaceutical composition disclosed by the invention, the synergistic antibacterial and anti-keratosis curative effects of adapalene and benzoyl peroxide can be maintained, and meanwhile, the occurrence rate of local skin dryness, erythema, desquamation, burning heat sensation and contact dermatitis can be remarkably reduced.

The invention relates to the technical field of skin medicines, in particular to a pharmaceutical composition for preventing or treating inflammatory skin diseases and application. The invention discloses a pharmaceutical composition for preventing or treating inflammatory skin diseases and application. The composition comprises active ingredients of astacin and derivatives thereof, p-toluene sulfonamide and derivatives thereof, and pharmaceutically or cosmetically acceptable excipients. Through the synergistic effect of the two active components, the composition can effectively inhibit skin inflammatory response, relieve pruritus and erythema and promote skin barrier repair and wound healing. The composition can be prepared into multiple external dosage forms such as cream, gel and spray, is suitable for preventing or treating multiple inflammatory skin diseases such as atopic dermatitis, eczema and psoriasis, and can also be used for repairing and nursing skin wounds. The external formula provided by the invention has both curative effect and safety, and provides a new choice for the treatment of inflammatory dermatosis.

The invention discloses a scalp repair composition as well as a preparation method and application thereof. The scalp repair composition comprises sericin, ceramide NP, a purslane extract, polysorbate-20 and a water-phase matrix, the sericin and the ceramide NP are compounded to simulate a natural scalp cuticle structure, and barrier reconstruction is facilitated; the purslane extract is used for relieving pruritus and erythema in the repairing process; the pH value of the composition is 5.0-5.8, so that the composition is more suitable for the weakly acidic microenvironment of the scalp, and the irritation is effectively reduced. The composition can be applied to scalp repair essence, anti-hair loss products and medical auxiliary dressings, and has good safety and repair efficacy.

The present invention relates to the technical field of medical examination, and provides a mental illness screening system, a chip, an apparatus, and a computer-readable storage medium. The system for screening for mental illness comprises the following modules: an image acquisition module, an ROI detection module, an ROI extraction module, a cropping module, a standardization module, an erythema segmentation module, a statistical feature extraction module, and a report generation module. By using the system of the present invention, it is possible to detect or diagnose whether an individual is suffering from depression. The method for using the system for screening for mental illness of the present invention is simple and highly accurate, and can quickly and conveniently complete a diagnosis procedure.

Provided herein are compositions and their use for the treatment of human skin, particularly facial skin, to alleviate the symptoms of cosmetic or dermatologic skin conditions. The compositions include black willow bark extract, cat's claw extract, and dragon's blood extract. The compositions ameliorate skin conditions including acne, rosacea, blemish, dermatitis, eczema, or the like.

The present invention relates to a cosmetic composition, advantageously an eco-biological cosmetic composition, comprising: - polyglutamic acid or a salt thereof; and - at least one peptide derivative represented by the general formula (I) in which: - R1 represents a hydrogen atom, an acyl radical or an acyloxy radical; and - R2 represents the side chain of an alpha-amino acid chosen from the group consisting of phenylalanine, glutamic acid, arginine, cysteine, methionine, histidine and tyrosine. The present invention also relates to the use of said cosmetic composition for combating skin redness and / or skin aging; to its use for preventing and / or combating cutaneous vascular hyperproliferation and / or cutaneous inflammation and / or rosacea; and to a method for selecting compounds suitable for preventing and / or combating these pathologies.

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a rabbit ear acne model for studying acne pathogenesis and drug curative effect. A healthy New Zealand large-ear white rabbit is selected, a testosterone solution is subcutaneously injected to induce endocrine disorder, oleic acid is smeared at an opening of an external auditory canal on the inner side of an ear, dermatobacterium acnes suspension is subcutaneously injected, and whether acne-like lesions such as erythema, papule and comedo appear on the skin of the ear or not is observed. The method is easy and convenient to operate, low in cost, good in repeatability, capable of simulating the pathological process of human acne and suitable for acne pathogenesis research and drug screening.

Administration of pentadecanoylcarnitine or pentadecanoic acid is provided for prevention, management or treatment of aggression, allergies, allergic rhinitis, Alzheimer's disease, anxiety and anxiety disorders, amyotrophic lateral sclerosis, arthritis, asthma, atherosclerosis, attention-deficit hyperactivity disorder, bipoloar disorder, brain damage, cancer, cardiovascular disease, cholestatic pruritis, depression, chronic obstructive pulmonary disease (COPD), cocaine abuse, cough, dermatitis, depression, drug-seeking behavior, gastrointestinal disorders, facial erythema associated with rosacea, glaucoma, hepatic diseases, hyperactive bladder, hypersensitivity disorders, hypertension, impulsivity, inflammation, mental disorders and conditions, metabolic disorders, migraines, nasal and sinus congestion, nausea, neuropathic pain with and symptoms of multiple sclerosis, neurological and neuropsychiatric disorders, obesity, obsessive-compulsive disorders, opioid-induced respiratory depression, osteoarthritis, pain, Parkinson disease, pathological gambling, peptic ulcers, schizophrenia, sleep disorders, spinal cord injury, tardive dyskinesia, tics and behavioral problems with Tourette's syndrome; as well as for supporting appetite, cardiovascular health, hematologic health, memory, metabolic health, mood, prolonged REM sleep, renal health, sexuality, sociability and metabolic, hematological, renal, and weight loss.

The embodiment of the application discloses a skin care prompting method and a skin care device. The method comprises the following steps: acquiring a skin image of a region to be cared, the skin image containing skin and hair; determining a hair state index of the region to be cared based on the skin image; and generating first prompting information in the case that the hair state index exceeds a preset index threshold, wherein the first prompting information is used for prompting a user to perform a hair shaving process first. In this way, through the intelligent judgment and prompting mechanism, the user can be actively guided to perform a standard preprocessing when the hair state index exceeds the preset index threshold, so as to avoid skin damage such as burns, erythema and stinging caused by excessive absorption of IPL energy by body hair, excessive heat diffusion and high epidermis temperature, thereby ensuring the safety of skin care operation, enabling more energy to act on hair follicles to improve the skin care effect, and improving the intelligent degree and use experience of the skin care device.

The invention relates to a traditional Chinese medicine external preparation for treating scalp inflammation. The traditional Chinese medicine external preparation is prepared from honeysuckle, radix sophorae flavescentis, fructus kochiae, cortex dictamni, dandelion, radix salviae miltiorrhizae, menthol, borneol and a transdermal enhancer. The preparation plays anti-inflammatory, bacteriostatic and barrier repairing roles through a multi-target synergistic mechanism, and is suitable for scalp inflammatory diseases such as seborrheic dermatitis and contact dermatitis. The preparation maximally retains active ingredients by adopting a specific extraction process, and the transdermal efficiency is improved by combining a triple permeation enhancing technology. The active ingredients reach the treatment concentration in the deep hair follicle. The pH value (5.5-6.0) of the preparation is matched with the weak acid environment of scalp, malassezia is selectively inhibited without damaging effective microbial communities, and the recurrence risk is reduced from the source. A spray, a lotion and a gel are proved to be capable of remarkably relieving erythema pruritus, inhibiting pathogenic bacteria colonization and accelerating cuticle repair, and have no skin irritation.

To provide a method for treating a disease. [Solution] The present invention relates to compounds, compositions and methods for modulating skin pigmentation in a subject, and for treating or preventing UV-induced skin damage, erythema, skin aging, sunburn and hyperpigmentation. The compounds, compositions and methods of the present invention generally include compounds derived from Malassezia, including malassezin and indirubin, and / or their chemical analogues. Other uses of the compounds and compositions disclosed herein include, but are not limited to, improvement of hyperpigmentation caused by hyperpigmentation disorders, including melanocyte apoptosis, and modulation of aromatic hydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogeneration, melanosome transport, melanocyte activity and melanin concentration.

The present invention relates to a composition for preventing or treating bladder diseases, a composition for preventing or treating neuropathic pain, neuroinflammation or inflammatory skin diseases, or the therapeutic use of a novel compound YJ102, the compound YJ102 of the present invention inhibits neuropathic pain due to various reasons, ameliorates urination disorders due to spinal cord injury, restores bladder hypertrophy and bladder function, inhibits erythema and keratinogenesis, which are main symptoms of psoriasis, in a psoriasis animal model, and has a superior effect than conventional drugs. The composition can inhibit increase of the thickness of the epidermal layer and spleen hypertrophy caused by psoriasis, and can be used for treating various difficult nervous system diseases or bladder diseases.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and / or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

This invention discloses a composition for relieving allergies, itching, and improving rough skin, its preparation method, and its application. The composition comprises the following active ingredients: asiaticoside, centella asiatica extract, kava extract, aescin, allantoin, and sodium hyaluronate. This invention prepares the composition using raw materials and proportions containing asiaticoside, centella asiatica extract, kava extract, aescin, allantoin, and sodium hyaluronate. The synergistic effect between these components results in excellent anti-allergic, anti-itch, and skin-roughening effects. After preparing the composition into a soothing and anti-itch cream, tests showed that it significantly reduced the a* value and lactic acid stinging score of sensitive skin. Doctor evaluation methods further confirmed its significant improvement effects on burning, erythema, swelling, peeling, stinging, and itching of sensitive skin, while also showing a significant effect on improving rough skin.

This invention provides a novel application of IdeS, which is used to prepare products addressing photoaging of the skin. These products include skincare products and pharmaceuticals for the prevention and / or treatment of photoaging. The pharmaceuticals are in the form of ointments, and the skincare products are used as adjunct treatments for preventing and treating photoaging. IdeS treatment significantly improves the extensive erythema, wrinkles, desquamation, inflammation, and thickened stratum corneum observed in photoaging model mice. It has been developed as a novel biological therapeutic drug with strong pharmacological effects, few side effects, and avoidance of allergic reactions, thus providing a basis for the clinical treatment of photoaging and photodamage.

The invention relates to a small transcranial magnetic stimulation positioning device and method based on remote control, and the device comprises a helmet, a control host, and a medical control host. A detection space is arranged in the helmet, a camera module and a three-axis moving module are arranged in the detection space, and a positioning unit and an angle adjusting module are arranged at the movable end of the three-axis moving module; the positioning unit comprises a mounting plate, guide sleeves are vertically arranged at four corners of the lower surface of the mounting plate, guide columns are slidably arranged on the guide sleeves in a penetrating manner, and a treatment coil is arranged on the lower surface of the mounting plate; the cost can be greatly reduced, and meanwhile, the method can be well implemented; the four pressure sensors not only can detect the head shape, but also can be directly associated with the treatment coil in hardware, the position of the treatment coil can be accurately and directly obtained, and meanwhile angle adjustment and height adjustment of the treatment coil can be conducted according to needs. By means of the device, continuous treatment of the erythema rosacea can be conveniently conducted on a patient at home.

Cosmetic and dietary supplement compositions containing silymarin and sulfoalkyl ether cyclodextrin, particularly sulfobutyl ether cyclodextrin, are described. The compositions and methods are useful in reducing appearance of facial redness in rosacea-prone skin, rejuvenating skin, preventing skin aging, inhibiting oxidative stress in epidermal and dermal cells, increasing collagen production, reducing the likelihood of skin cancer, treating or reducing liver damage from a toxin, or treating a liver disease.

The method of the embodiment of the application proposes a multi-modal data fusion postoperative infection early warning method and system. First, the postoperative wound image, clinical text, wearable vital signs and baseline features are quality evaluated and repaired. The repaired image is double-flow encoded and the coarse mask is obtained by prior segmentation. The superpixel graph is constructed and the topologically consistent fine mask is obtained by the graph neural network to quantify the erythema / effusion area. The text and vital signs are encoded and fused with the image features and the mask through cross-attention and self-attention, and the fused hidden vector and uncertainty are obtained through the quality weight gate. The individualized dynamic threshold is constructed by combining the baseline risk, the logit calibration and the sliding window trend, the shape-preserving prediction output confidence band is used to realize the early and reliable infection early warning.

The invention discloses an application of sarcandra glabra polysaccharide in preparation of a medicine for preventing and / or treating psoriasis and delaying relapse of psoriasis. The glabrous sarcandra herb polysaccharide can relieve inflammation caused by psoriasis, reduce expression of memory T cells at skin lesions of a psoriasis recurrence model mouse and relieve psoriasis symptoms of the recurrence model mouse. The invention finds that the glabrous sarcandra herb polysaccharide can obviously improve the skin injury degree of an imiquimod (imiquimod, IMQ) interval induced psoriasis recurrence model mouse, reduce the skin erythema, thickening and scale of the IMQ interval induced psoriasis recurrence model mouse, and reduce the expression of memory T cells at the skin injury part of the psoriasis recurrence model mouse, so that the glabrous sarcandra herb polysaccharide can be used for treating the psoriasis. The glabrous sarcandra herb polysaccharide has great application prospects in preparation of the medicine for preventing / treating the psoriasis, and especially can relieve recurrence symptoms of the psoriasis.