72 results about "Erythema" patented technology

The invention discloses application of tea extracellular vesicles in preparation of a product for preventing and / or treating UVB-induced skin photoaging, and belongs to the technical field of application of the tea extracellular vesicles. The tea extracellular vesicles are derived from tea leaves and / or stem leaves and are prepared by a method of combining enzymolysis, multi-stage filtration and ultracentrifugation, and the particle size of the tea extracellular vesicles is mainly distributed in a range of 60-100nm. Experiments show that the tea extracellular vesicles can effectively reduce active oxygen accumulation and lipid peroxidation caused by UVB radiation, repair mitochondrial membrane potential and inhibit expression of matrix metalloproteinase and inflammatory factors, so that photoaging symptoms such as skin wrinkles, erythema and barrier function damage are relieved. The tea extracellular vesicle provided by the invention has the advantages of natural raw materials, good biocompatibility, small side effect and the like, can be used for preparing a plurality of external dosage forms such as gel, cream, spray and the like, and provides a safe and effective new natural product choice for prevention and treatment of skin photoaging.

The invention relates to a pharmaceutical composition, which is prepared from adapalene, benzoyl peroxide, a traditional Chinese medicine extract, an acrylamide and acryloyl dimethyl sodium taurate copolymer, a mixture of isohexadecane and polysorbate 80, docusate sodium, EDTA (Ethylene Diamine Tetraacetic Acid) disodium, glycerol, poloxamer 124, propylene glycol and water, the traditional Chinese medicine extract comprises moutan bark, salvia miltiorrhiza, radix rehmanniae recen, radix sophorae flavescentis, coptis chinensis, rheum officinale, scutellaria baicalensis, menthol and borneol. According to the pharmaceutical composition disclosed by the invention, the synergistic antibacterial and anti-keratosis curative effects of adapalene and benzoyl peroxide can be maintained, and meanwhile, the occurrence rate of local skin dryness, erythema, desquamation, burning heat sensation and contact dermatitis can be remarkably reduced.

The present invention relates to the technical field of medical examination, and provides a mental illness screening system, a chip, an apparatus, and a computer-readable storage medium. The system for screening for mental illness comprises the following modules: an image acquisition module, an ROI detection module, an ROI extraction module, a cropping module, a standardization module, an erythema segmentation module, a statistical feature extraction module, and a report generation module. By using the system of the present invention, it is possible to detect or diagnose whether an individual is suffering from depression. The method for using the system for screening for mental illness of the present invention is simple and highly accurate, and can quickly and conveniently complete a diagnosis procedure.

The present invention relates to a cosmetic composition, advantageously an eco-biological cosmetic composition, comprising: - polyglutamic acid or a salt thereof; and - at least one peptide derivative represented by the general formula (I) in which: - R1 represents a hydrogen atom, an acyl radical or an acyloxy radical; and - R2 represents the side chain of an alpha-amino acid chosen from the group consisting of phenylalanine, glutamic acid, arginine, cysteine, methionine, histidine and tyrosine. The present invention also relates to the use of said cosmetic composition for combating skin redness and / or skin aging; to its use for preventing and / or combating cutaneous vascular hyperproliferation and / or cutaneous inflammation and / or rosacea; and to a method for selecting compounds suitable for preventing and / or combating these pathologies.

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a rabbit ear acne model for studying acne pathogenesis and drug curative effect. A healthy New Zealand large-ear white rabbit is selected, a testosterone solution is subcutaneously injected to induce endocrine disorder, oleic acid is smeared at an opening of an external auditory canal on the inner side of an ear, dermatobacterium acnes suspension is subcutaneously injected, and whether acne-like lesions such as erythema, papule and comedo appear on the skin of the ear or not is observed. The method is easy and convenient to operate, low in cost, good in repeatability, capable of simulating the pathological process of human acne and suitable for acne pathogenesis research and drug screening.

Administration of pentadecanoylcarnitine or pentadecanoic acid is provided for prevention, management or treatment of aggression, allergies, allergic rhinitis, Alzheimer's disease, anxiety and anxiety disorders, amyotrophic lateral sclerosis, arthritis, asthma, atherosclerosis, attention-deficit hyperactivity disorder, bipoloar disorder, brain damage, cancer, cardiovascular disease, cholestatic pruritis, depression, chronic obstructive pulmonary disease (COPD), cocaine abuse, cough, dermatitis, depression, drug-seeking behavior, gastrointestinal disorders, facial erythema associated with rosacea, glaucoma, hepatic diseases, hyperactive bladder, hypersensitivity disorders, hypertension, impulsivity, inflammation, mental disorders and conditions, metabolic disorders, migraines, nasal and sinus congestion, nausea, neuropathic pain with and symptoms of multiple sclerosis, neurological and neuropsychiatric disorders, obesity, obsessive-compulsive disorders, opioid-induced respiratory depression, osteoarthritis, pain, Parkinson disease, pathological gambling, peptic ulcers, schizophrenia, sleep disorders, spinal cord injury, tardive dyskinesia, tics and behavioral problems with Tourette's syndrome; as well as for supporting appetite, cardiovascular health, hematologic health, memory, metabolic health, mood, prolonged REM sleep, renal health, sexuality, sociability and metabolic, hematological, renal, and weight loss.

To provide a method for treating a disease. [Solution] The present invention relates to compounds, compositions and methods for modulating skin pigmentation in a subject, and for treating or preventing UV-induced skin damage, erythema, skin aging, sunburn and hyperpigmentation. The compounds, compositions and methods of the present invention generally include compounds derived from Malassezia, including malassezin and indirubin, and / or their chemical analogues. Other uses of the compounds and compositions disclosed herein include, but are not limited to, improvement of hyperpigmentation caused by hyperpigmentation disorders, including melanocyte apoptosis, and modulation of aromatic hydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogeneration, melanosome transport, melanocyte activity and melanin concentration.

This invention discloses a composition for relieving allergies, itching, and improving rough skin, its preparation method, and its application. The composition comprises the following active ingredients: asiaticoside, centella asiatica extract, kava extract, aescin, allantoin, and sodium hyaluronate. This invention prepares the composition using raw materials and proportions containing asiaticoside, centella asiatica extract, kava extract, aescin, allantoin, and sodium hyaluronate. The synergistic effect between these components results in excellent anti-allergic, anti-itch, and skin-roughening effects. After preparing the composition into a soothing and anti-itch cream, tests showed that it significantly reduced the a* value and lactic acid stinging score of sensitive skin. Doctor evaluation methods further confirmed its significant improvement effects on burning, erythema, swelling, peeling, stinging, and itching of sensitive skin, while also showing a significant effect on improving rough skin.

This invention provides a novel application of IdeS, which is used to prepare products addressing photoaging of the skin. These products include skincare products and pharmaceuticals for the prevention and / or treatment of photoaging. The pharmaceuticals are in the form of ointments, and the skincare products are used as adjunct treatments for preventing and treating photoaging. IdeS treatment significantly improves the extensive erythema, wrinkles, desquamation, inflammation, and thickened stratum corneum observed in photoaging model mice. It has been developed as a novel biological therapeutic drug with strong pharmacological effects, few side effects, and avoidance of allergic reactions, thus providing a basis for the clinical treatment of photoaging and photodamage.

The invention relates to a small transcranial magnetic stimulation positioning device and method based on remote control, and the device comprises a helmet, a control host, and a medical control host. A detection space is arranged in the helmet, a camera module and a three-axis moving module are arranged in the detection space, and a positioning unit and an angle adjusting module are arranged at the movable end of the three-axis moving module; the positioning unit comprises a mounting plate, guide sleeves are vertically arranged at four corners of the lower surface of the mounting plate, guide columns are slidably arranged on the guide sleeves in a penetrating manner, and a treatment coil is arranged on the lower surface of the mounting plate; the cost can be greatly reduced, and meanwhile, the method can be well implemented; the four pressure sensors not only can detect the head shape, but also can be directly associated with the treatment coil in hardware, the position of the treatment coil can be accurately and directly obtained, and meanwhile angle adjustment and height adjustment of the treatment coil can be conducted according to needs. By means of the device, continuous treatment of the erythema rosacea can be conveniently conducted on a patient at home.

The method of the embodiment of the application proposes a multi-modal data fusion postoperative infection early warning method and system. First, the postoperative wound image, clinical text, wearable vital signs and baseline features are quality evaluated and repaired. The repaired image is double-flow encoded and the coarse mask is obtained by prior segmentation. The superpixel graph is constructed and the topologically consistent fine mask is obtained by the graph neural network to quantify the erythema / effusion area. The text and vital signs are encoded and fused with the image features and the mask through cross-attention and self-attention, and the fused hidden vector and uncertainty are obtained through the quality weight gate. The individualized dynamic threshold is constructed by combining the baseline risk, the logit calibration and the sliding window trend, the shape-preserving prediction output confidence band is used to realize the early and reliable infection early warning.

When the oxygen isolation type photodynamic therapy device is used, the light-transmitting oxygen isolation type equipment covers the skin lesion surface of a patient to form an oxygen isolation layer, the tissue oxygen concentration of the epidermal layer and the dermal superficial layer of the patient can be reduced, and therefore the singlet oxygen photochemical generation rate of the area is reduced, and the photodynamic therapy effect is improved. The level of photochemical pain reaction caused by singlet oxygen during treatment of a patient is reduced; meanwhile, the method is cooperated with a light modulation technology, so that the singlet oxygen accumulation damage ratio of the targeted tissue and the non-targeted tissue can be further improved. Meanwhile, target cells of the erythema are located on capillary walls, target cells of skin precancerous lesions are located near a basal layer, and the oxygen concentration of the places is higher than that of an epidermal layer, so that the target selectivity of photodynamic therapy can be improved; the material can be used for hypoxia photodynamic therapy of nevus flammeus, skin precancerous lesions and other skin diseases.

This invention belongs to the field of biomedical technology, specifically relating to the application of SMOC2 protein in the preparation of psoriasis treatment drugs. The amino acid sequence of the SMOC2 protein is shown in SEQ ID NO.1. This invention has discovered that SMOC2 protein can treat psoriasis, and therefore provides the application of SMOC2 protein in the preparation of psoriasis treatment drugs. Using SMOC2 protein can treat or improve the scaling, erythema, and thickening phenotypes of the skin, as well as inhibit the abnormal proliferation of keratinocytes and the expression of inflammatory factors IL1β, IL23, cAMP, TNFα, CXCL2, CXCL3, S100A8, and S100A9. By inhibiting the infiltration of neutrophils in inflammatory cells in psoriatic lesions, it exerts a therapeutic or alleviating effect on inflammatory skin diseases.

This invention relates to a multimodal feature-based system for identifying and evaluating the therapeutic effect of port-wine stains, and an electronic device, comprising: a multimodal data acquisition module for acquiring multimodal facial data; a data preprocessing module for performing quality inspection, noise reduction, and standardization on the multimodal data; an erythema identification module that uses a hybrid model combining pathological guidance, multi-scale vision, and semantically enhanced text to output facial erythema classification results based on the preprocessed multimodal data; a feature linkage module that establishes a mapping relationship between PWS (Prognostic and Surface Therapy) identification features and therapeutic effect evaluation features: if the facial erythema classification result output by the erythema identification module is port-wine stains, then the core features for therapeutic effect evaluation are extracted; and a therapeutic effect evaluation module that, based on the core features for therapeutic effect evaluation and post-treatment multimodal data of the same type, calculates the color fading rate, area reduction rate, and thickness improvement rate of port-wine stains, and outputs a comprehensive therapeutic effect evaluation result.

Cosmetic and dietary supplement compositions containing silymarin and sulfoalkyl ether cyclodextrin, particularly sulfobutyl ether cyclodextrin, are described. The compositions and methods are useful in reducing appearance of facial redness in rosacea-prone skin, rejuvenating skin, preventing skin aging, inhibiting oxidative stress in epidermal and dermal cells, increasing collagen production, reducing the likelihood of skin cancer, treating or reducing liver damage from a toxin, or treating a liver disease.

A method for reducing the appearance of fine lines or wrinkles, treating skin inflammation, or reducing the appearance of reddened or erythemic skin is disclosed. The method can include applying to skin having a fine line or wrinkle, having inflammation, or having a reddened or erythymic appearance a composition that includes tetrahexyldecyl ascorbate and Acmella oleracea extract, wherein application of the composition to the skin reduces the appearance of the fine line or wrinkle, treats skin inflammation, or reduces the appearance of the reddened or erythemic skin.

The present invention relates to a method for determining UV protection efficacy of functional cosmetics on the basis of AI and, particularly, to a UV protection efficacy determination method comprising: applying functional cosmetics to a subject's skin; subsequently irradiating the skin with UV light; and determining protection efficacy by observing changes in the skin, wherein the observing of the changes in the skin irradiated with UV light is performed through detection of erythema or pigment darkening by an artificial intelligence algorithm from an image obtained by capturing the subject's skin; and the artificial intelligence algorithm performs the detection of erythema or pigment darkening by applying skin tone information calculated from an image obtained by capturing the subject's skin not irradiated with UV light. According to the present invention, UV protection efficacy is determined using artificial intelligence, so that the determination of the UV protection efficacy is objectified, and the reliability of determination results increases. In addition, since the determination process is automated by artificial intelligence, time required for determination can be reduced.

The present invention relates to a novel compound YJ102 for the prevention or treatment of bladder diseases, a composition for the prevention or treatment of neuropathic pain, neuroinflammation, or inflammatory skin diseases, or for the treatment of intractable neurological diseases including neurogenic bladder. The compound YJ102 of the present invention suppresses neuropathic pain caused by various factors with superior efficacy compared to conventional drugs, improves urinary dysfunction caused by spinal cord injury, restores bladder enlargement and bladder function, suppresses the development of erythema and scaling, which are major symptoms of psoriasis in animal models of psoriasis, suppresses thickening of the epidermal layer, and suppresses splenomegaly caused by psoriasis. Therefore, it can be utilized for the treatment of various intractable neurological diseases or bladder diseases.

The present disclosure relates to compositions and methods useful for dietary augmentation to provide therapeutic intervention for the amelioration of symptoms associated with rosacea-prone skin. According to one embodiment of the present disclosure, there is provided an orally administrable composition containing a therapeutically effective amount of: (a) a probiotic blend of bacterial components containing at least: (i) Lactobacillus helveticus, (ii) Lactobacillus plantarum, (iii) Bifidobacterium longum, and (iii) Streptococcus thermophilus; and (b) at least one plant-based, antioxidant-rich source of fiber.

The invention discloses an externally-applied traditional Chinese medicine ointment for treating radioactive skin injury and a preparation method thereof, and relates to the technical field of externally-applied traditional Chinese medicines. The externally-applied traditional Chinese medicine ointment is prepared from the following components in parts by weight: traditional Chinese medicine raw materials, targeted active ingredients and functional auxiliary materials, the traditional Chinese medicine raw materials comprise 30 parts of borneol, 30 parts of talc, 10 parts of radix sophorae flavescentis, 10 parts of fructus cnidii, 5 parts of frankincense, 5 parts of myrrh, 6 parts of fructus forsythiae, 10 parts of calamine, 10 parts of rheum officinale, 15 parts of mirabilite and 10 parts of cortex phellodendri. According to the external application traditional Chinese medicine ointment, classic traditional Chinese medicines such as borneol and talc are compatible and optimally proportioned, the effects of pungent and fragrant movement, heat clearing, pain relieving, inflammation resisting and itching relieving of the borneol are utilized, the effects of heat clearing, dampness astringing, sore astringing and skin barrier protecting of the talc are combined, intervention is achieved on core symptoms such as erythema, pruritus and erosion of acute radiodermatitis, and the traditional Chinese medicine ointment is safe and reliable. Different from an existing traditional Chinese medicine external preparation with a single effect, adverse reactions of western medicine hormones and growth factors are also avoided.

A pharmaceutical composition for treating moderate or severe rosacea comprises a formulated, body weight-independent low dose of minocycline that reduces the severity of rosacea in at least 2 weeks with a decrease in lesion count, Investigator's Global Assessment (IGA) score, and Clinician's Erythema Assessment (CEA) score with a measured improvement in quality of life.

The present disclosure relates generally to cosmetic compositions comprising a Crocus sativus flower extract, and their use for skin treatment, particularly as anti-dandruff. The compositions provide very significant anti-dandruff, anti-fungal, anti-erythema, skin soothing, and antipruritic effects, and also improve skin barrier integrity.

The application provides a composition for regulating intestinal flora to intervene in rose acne, comprising oral preparations and skin external preparations thereof, and relates to the technical field of biological medicines.The composition is composed of a prebiotic component inulin or a dandelion water extract containing inulin, and a humanized rhamnosus strain or a bacterial body lysate, culture supernatant or metabolite thereof.The composition can promote the proliferation of the humanized rhamnosus in the intestinal tract after being taken orally, significantly enhance the tryptophan metabolism capacity of the humanized rhamnosus, and improve the intestinal indole-3-lactic acid level;ILA enters blood through the intestinal-skin axis, and acts on the skin keratinocyte aromatic receptor, so that the immune homeostasis is systematically regulated and the skin inflammation is relieved.Experiments prove that the composition has a significant prevention and intervention effect on a rose acne model of mice induced by LL-37, can reduce the erythema area, and relieve the inflammatory symptoms.

The application discloses a traditional Chinese medicine composition for photoelectric medical and aesthetic postoperative skin repair and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials: white bletilla, honeysuckle, wild chrysanthemum, sophora flower and campsis flower. The traditional Chinese medicine composition can effectively treat and alleviate the skin barrier damage symptoms after photoelectric medical and aesthetic operation, such as erythema, edema and post-inflammatory hyperpigmentation. The traditional Chinese medicine composition takes white bletilla and honeysuckle as monarch drugs, lays the foundation for anti-inflammatory repair; takes sophora flower and wild chrysanthemum as ministerial drugs, removes ROS, stabilizes capillaries to fade red and resist inflammation; and takes campsis flower as an auxiliary drug to improve microcirculation and promote synergistic effect, finally forms the core action mechanism of 'fading red-anti-inflammatory-repair', effectively solves the barrier damage problems such as erythema, edema and hyperpigmentation after photoelectric operation, expands the application scene of traditional Chinese medicine in the field of medical and aesthetic repair, and has significant technical superiority compared with the prior art.

The invention provides an application of acetyl alkannin in treatment of psoriasis. Specifically, the invention verifies that acetyl alkannin can improve skin lesion erythema, scales and skin thickening caused by psoriasis and inhibit infiltration of immune cells. The invention also provides an application of the acetyl alkannin and the pharmaceutical composition thereof in preparation of drugs for treating psoriasis. The invention also provides a method for treating psoriasis.

The invention discloses an application of a novel peptide UPCP in preparation of a medicine for treating and / or preventing psoriasis. Belongs to the technical field of biological medicine. The application discloses the treatment effect of the novel peptide UPCP on psoriasis for the first time, and researches find that the novel peptide UPCP can effectively relieve symptoms of a psoriasis model induced by LSP, TNF alpha and M2 in an in-vitro cell experiment, significantly down-regulate the expression level of psoriasis cell markers, significantly reduce the transcriptional level of psoriasis-related inflammatory factors, and improve the psoriasis treatment effect. The condition of excessive proliferation of HaCaT cells is effectively reduced. In in-vivo experiments, psoriasis symptoms such as skin desquamation, hyperplasia, erythema, thickening and splenomegaly of an imiquimod-induced psoriasis mouse model can be effectively relieved, the effect of treating psoriasis is achieved, and a new theoretical basis and intervention means are provided for clinical treatment of psoriasis.

The application relates to application of cedrene diol in preparation of medicines for preventing and treating rosacea, and belongs to the technical field of biological medicines. The application provides application of cedrene diol in preparation of medicines for preventing and / or treating rosacea. The cedrene diol can significantly improve redness and inflammation of an injection area of a rosacea mouse model in long and short terms, can significantly relieve skin histopathological inflammation of the rosacea mouse model (including improving thickening of skin epidermis of the rosacea mouse model, reducing inflammatory cell infiltration of skin tissue of the rosacea mouse model, and reducing capillary proliferation of skin tissue of the rosacea mouse model), can significantly reduce skin inflammation of a rosacea patient (including reducing pain of the skin of the rosacea patient and relieving redness of the skin of the rosacea patient), and can significantly improve skin damage of the rosacea patient (including improving papules and pustules of the skin of the rosacea patient).

A pharmaceutical composition for treating moderate or severe rosacea comprises a formulated, body weight-independent low dose of minocycline that reduces the severity of rosacea in at least 2 weeks with a decrease in lesion count, Investigator's Global Assessment (IGA) score, and Clinician's Erythema Assessment (CEA) score with a measured improvement in quality of life.