28 results about "Erythema" patented technology

The present invention relates to a cosmetic composition, advantageously an eco-biological cosmetic composition, comprising: - polyglutamic acid or a salt thereof; and - at least one peptide derivative represented by the general formula (I) in which: - R1 represents a hydrogen atom, an acyl radical or an acyloxy radical; and - R2 represents the side chain of an alpha-amino acid chosen from the group consisting of phenylalanine, glutamic acid, arginine, cysteine, methionine, histidine and tyrosine. The present invention also relates to the use of said cosmetic composition for combating skin redness and / or skin aging; to its use for preventing and / or combating cutaneous vascular hyperproliferation and / or cutaneous inflammation and / or rosacea; and to a method for selecting compounds suitable for preventing and / or combating these pathologies.

Administration of pentadecanoylcarnitine or pentadecanoic acid is provided for prevention, management or treatment of aggression, allergies, allergic rhinitis, Alzheimer's disease, anxiety and anxiety disorders, amyotrophic lateral sclerosis, arthritis, asthma, atherosclerosis, attention-deficit hyperactivity disorder, bipoloar disorder, brain damage, cancer, cardiovascular disease, cholestatic pruritis, depression, chronic obstructive pulmonary disease (COPD), cocaine abuse, cough, dermatitis, depression, drug-seeking behavior, gastrointestinal disorders, facial erythema associated with rosacea, glaucoma, hepatic diseases, hyperactive bladder, hypersensitivity disorders, hypertension, impulsivity, inflammation, mental disorders and conditions, metabolic disorders, migraines, nasal and sinus congestion, nausea, neuropathic pain with and symptoms of multiple sclerosis, neurological and neuropsychiatric disorders, obesity, obsessive-compulsive disorders, opioid-induced respiratory depression, osteoarthritis, pain, Parkinson disease, pathological gambling, peptic ulcers, schizophrenia, sleep disorders, spinal cord injury, tardive dyskinesia, tics and behavioral problems with Tourette's syndrome; as well as for supporting appetite, cardiovascular health, hematologic health, memory, metabolic health, mood, prolonged REM sleep, renal health, sexuality, sociability and metabolic, hematological, renal, and weight loss.

To provide a method for treating a disease. [Solution] The present invention relates to compounds, compositions and methods for modulating skin pigmentation in a subject, and for treating or preventing UV-induced skin damage, erythema, skin aging, sunburn and hyperpigmentation. The compounds, compositions and methods of the present invention generally include compounds derived from Malassezia, including malassezin and indirubin, and / or their chemical analogues. Other uses of the compounds and compositions disclosed herein include, but are not limited to, improvement of hyperpigmentation caused by hyperpigmentation disorders, including melanocyte apoptosis, and modulation of aromatic hydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogeneration, melanosome transport, melanocyte activity and melanin concentration.

This invention provides a novel application of IdeS, which is used to prepare products addressing photoaging of the skin. These products include skincare products and pharmaceuticals for the prevention and / or treatment of photoaging. The pharmaceuticals are in the form of ointments, and the skincare products are used as adjunct treatments for preventing and treating photoaging. IdeS treatment significantly improves the extensive erythema, wrinkles, desquamation, inflammation, and thickened stratum corneum observed in photoaging model mice. It has been developed as a novel biological therapeutic drug with strong pharmacological effects, few side effects, and avoidance of allergic reactions, thus providing a basis for the clinical treatment of photoaging and photodamage.

A method for reducing the appearance of fine lines or wrinkles, treating skin inflammation, or reducing the appearance of reddened or erythemic skin is disclosed. The method can include applying to skin having a fine line or wrinkle, having inflammation, or having a reddened or erythymic appearance a composition that includes tetrahexyldecyl ascorbate and Acmella oleracea extract, wherein application of the composition to the skin reduces the appearance of the fine line or wrinkle, treats skin inflammation, or reduces the appearance of the reddened or erythemic skin.

The present invention relates to a method for determining UV protection efficacy of functional cosmetics on the basis of AI and, particularly, to a UV protection efficacy determination method comprising: applying functional cosmetics to a subject's skin; subsequently irradiating the skin with UV light; and determining protection efficacy by observing changes in the skin, wherein the observing of the changes in the skin irradiated with UV light is performed through detection of erythema or pigment darkening by an artificial intelligence algorithm from an image obtained by capturing the subject's skin; and the artificial intelligence algorithm performs the detection of erythema or pigment darkening by applying skin tone information calculated from an image obtained by capturing the subject's skin not irradiated with UV light. According to the present invention, UV protection efficacy is determined using artificial intelligence, so that the determination of the UV protection efficacy is objectified, and the reliability of determination results increases. In addition, since the determination process is automated by artificial intelligence, time required for determination can be reduced.

The present invention relates to a novel compound YJ102 for the prevention or treatment of bladder diseases, a composition for the prevention or treatment of neuropathic pain, neuroinflammation, or inflammatory skin diseases, or for the treatment of intractable neurological diseases including neurogenic bladder. The compound YJ102 of the present invention suppresses neuropathic pain caused by various factors with superior efficacy compared to conventional drugs, improves urinary dysfunction caused by spinal cord injury, restores bladder enlargement and bladder function, suppresses the development of erythema and scaling, which are major symptoms of psoriasis in animal models of psoriasis, suppresses thickening of the epidermal layer, and suppresses splenomegaly caused by psoriasis. Therefore, it can be utilized for the treatment of various intractable neurological diseases or bladder diseases.

The present disclosure relates generally to cosmetic compositions comprising a Crocus sativus flower extract, and their use for skin treatment, particularly as anti-dandruff. The compositions provide very significant anti-dandruff, anti-fungal, anti-erythema, skin soothing, and antipruritic effects, and also improve skin barrier integrity.

The application provides a composition for regulating intestinal flora to intervene in rose acne, comprising oral preparations and skin external preparations thereof, and relates to the technical field of biological medicines.The composition is composed of a prebiotic component inulin or a dandelion water extract containing inulin, and a humanized rhamnosus strain or a bacterial body lysate, culture supernatant or metabolite thereof.The composition can promote the proliferation of the humanized rhamnosus in the intestinal tract after being taken orally, significantly enhance the tryptophan metabolism capacity of the humanized rhamnosus, and improve the intestinal indole-3-lactic acid level;ILA enters blood through the intestinal-skin axis, and acts on the skin keratinocyte aromatic receptor, so that the immune homeostasis is systematically regulated and the skin inflammation is relieved.Experiments prove that the composition has a significant prevention and intervention effect on a rose acne model of mice induced by LL-37, can reduce the erythema area, and relieve the inflammatory symptoms.

The application discloses a traditional Chinese medicine composition for photoelectric medical and aesthetic postoperative skin repair and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials: white bletilla, honeysuckle, wild chrysanthemum, sophora flower and campsis flower. The traditional Chinese medicine composition can effectively treat and alleviate the skin barrier damage symptoms after photoelectric medical and aesthetic operation, such as erythema, edema and post-inflammatory hyperpigmentation. The traditional Chinese medicine composition takes white bletilla and honeysuckle as monarch drugs, lays the foundation for anti-inflammatory repair; takes sophora flower and wild chrysanthemum as ministerial drugs, removes ROS, stabilizes capillaries to fade red and resist inflammation; and takes campsis flower as an auxiliary drug to improve microcirculation and promote synergistic effect, finally forms the core action mechanism of 'fading red-anti-inflammatory-repair', effectively solves the barrier damage problems such as erythema, edema and hyperpigmentation after photoelectric operation, expands the application scene of traditional Chinese medicine in the field of medical and aesthetic repair, and has significant technical superiority compared with the prior art.

The application relates to application of cedrene diol in preparation of medicines for preventing and treating rosacea, and belongs to the technical field of biological medicines. The application provides application of cedrene diol in preparation of medicines for preventing and / or treating rosacea. The cedrene diol can significantly improve redness and inflammation of an injection area of a rosacea mouse model in long and short terms, can significantly relieve skin histopathological inflammation of the rosacea mouse model (including improving thickening of skin epidermis of the rosacea mouse model, reducing inflammatory cell infiltration of skin tissue of the rosacea mouse model, and reducing capillary proliferation of skin tissue of the rosacea mouse model), can significantly reduce skin inflammation of a rosacea patient (including reducing pain of the skin of the rosacea patient and relieving redness of the skin of the rosacea patient), and can significantly improve skin damage of the rosacea patient (including improving papules and pustules of the skin of the rosacea patient).

This invention belongs to the field of pharmaceutical technology and discloses a tribulus terrestris saponin gel formulation for repairing acute photodamage to the skin, its preparation method, and its application. The tribulus terrestris saponin gel formulation comprises a therapeutically effective amount of tribulus terrestris saponin, a gel matrix, and a transdermal absorption enhancing system. The transdermal absorption enhancing system consists of a pH adjuster and a chemical penetration enhancer, wherein the pH value of the gel formulation is adjusted to 5.8–6.5. The preparation method includes steps such as blank gel preparation, drug and penetration enhancer solution preparation, mixing to form a gel, pH adjustment, and volume fixation. This formulation, through precise pH matching and synergistic application of an azone-ethanol penetration enhancing system, significantly improves the transdermal penetration efficiency and skin retention of tribulus terrestris saponin, improves symptoms such as erythema and desquamation caused by acute photodamage to the skin, exhibits high safety, demonstrates more sustained drug release behavior, and thus achieves superior cumulative concentration and long-lasting repair effect at the site of acute photodamage to the skin.

This invention provides a topical traditional Chinese medicine preparation for treating fungal skin infections and its preparation method, belonging to the field of biomedical technology. The topical traditional Chinese medicine preparation is based on traditional Chinese medicine theory and scientifically formulated, using *Ling Shou Ci*, *Da Cha Gen*, *Fu Fang Teng*, *Mesona chinensis*, *Bai La Jiao*, *Bai Niu Wei Qi*, *Nai Zhi Shu*, *Di Yu*, and *Er Cao* as raw materials. The extracts prepared from the above-mentioned medicinal materials exhibit strong antibacterial and bactericidal effects against *Trichophyton rubrum*, *Trichophyton mentagrophytes*, and *Microsporum gypseum*, inhibiting the development of pathogens at the source. The topical traditional Chinese medicine preparation can significantly inhibit the body's inflammatory response, effectively improving and alleviating skin lesions such as erythema, papules, desquamation, alopecia, and inflammatory infiltration caused by fungal infections. It has a significant therapeutic effect on fungal skin diseases, and the topical traditional Chinese medicine preparation provided by this invention has great potential for application in the treatment of fungal skin diseases.

This application relates to formulations in powder form comprising sodium isethionate, aloe vera leaves, colloidal oatmeal, coconut milk or coconut oil, powdered jojoba vegetable oil, powdered copaiba resin oil, acacia senegal gum, soy lecithin, powdered lemongrass essential oil, powdered rosemary oleoresin, sodium gluconate, maize starch and arrowroot powder for use as soap and / or shampoo, gently cleansing the skin and scalp whilst protecting the skin barrier. The selected natural active ingredients are capable of reducing inflammation, soothing, treating and revitalising sensitive, reactive skin prone to conditions and inflammation, as well as maintaining the health of normal skin and hair. The focus is on protection and hydration in a formula packed with natural antioxidants, and the final formulation is suitable for all skin and hair / scalp types, from normal, dry or oily to reactive and sensitive skin affected by psoriasis, atopic dermatitis and / or erythema.

Compounds can specifically activate TLR7. The compounds are useful because they can stimulate innate immunity. The compounds can be used in the treatment of conditions including cancer, viral infections and skin lesions. The compounds can optionally be formulated for enhanced penetration following topical administration, the composition preferably initiating a local specific inflammatory cytokine response while limiting undesirable erythema and other inflammatory reactions. Pharmaceutical compositions contain the compound and preferably an additional compound such as imiquimod and / or resiquimod (R848). A composition contains the compound and a compound can be used as a medicament. Other aspects, embodiments, advantages and applications will become clear from the further description herein.

The application discloses a patient skin pressure sore risk image evaluation method and system, and relates to the field of medical image processing.The method comprises the following steps: acquiring a skin image by using a standardized acquisition device and performing color correction; converting the image to a Lab color space to extract a channel abnormal value, calculate a redness degree index and a red spot area proportion; calculating a roughness and uniformity index of skin texture based on a gray level co-occurrence matrix; registering and fusing a visible light image and an infrared thermal image to detect a temperature abnormal area; registering and comparing the current image with historical records to quantify a skin state change trend; and calculating a pressure sore risk score by weighted fusion of multi-dimensional features and outputting a nursing suggestion.The application realizes early warning and objective quantitative evaluation of pressure sore risk, and the accuracy rate is above 92%.

The present invention provides a Lotilaner-containing microemulsion eye drop, a preparation method therefor, and a use thereof in eye diseases such as demodex blepharitis, ocular rosacea, and meibomian gland dysfunction.

This invention discloses an artificial intelligence-based rosacea diagnostic system, including a data governance module and a multimodal model training and inference module. The data governance module is used to process the collected facial data, and the multimodal model training and inference module is used to uniformly model the images and derived modal features output by the data governance module, perform erythema region segmentation, papule / pustule and comedo detection, and further obtain diagnostic probability and severity classification, providing interpretable structured results.

This application relates to an image-assisted classification method, system, computer device, and storage medium. The method includes: acquiring a patch test image to be classified; the patch test image is a skin image acquired after patch removal; inputting the patch test image into a pre-trained patch image classification model to obtain a classification result of a predicted type; the predicted type includes a normal reaction type and a mild erythema reaction type; the patch image classification model is obtained by training a deep learning model based on a preset patch test sample set (content of claim 1). This method can assist experts in improving classification efficiency and objectivity in the mild erythema assessment process.

This invention provides a semi-fluorinated alkane eye drop containing loteranal and its preparation method, as well as its application in eye diseases such as Demodex blepharitis, ocular erythema acne, and meibomian gland dysfunction.

This invention relates to the field of traditional Chinese medicine extracts and drug preparation technology, and discloses a *Hypericum perforatum* extract composition, its preparation method, and its application, including the application of an ethanol extract of *Hypericum perforatum* or components isolated from its ethanol extract in the preparation of drugs for the prevention and / or treatment of psoriasis. In vitro and in vivo experiments have demonstrated that *Hypericum perforatum* extract can significantly improve imiquimod (IMQ)-induced psoriasis-like skin lesions (erythema, scaling, and skin thickening) in mice and reduce PASI scores. Its mechanism of action differs from single-target biological agents; instead, it simultaneously regulates the IL-23 / IL-17 inflammatory axis, corrects Th17 / Treg immune imbalance, and inhibits abnormal activation of the NF-κB signaling pathway, demonstrating the advantages of multi-component, multi-target synergistic effects of natural drugs. Furthermore, *Hypericum perforatum* is a unique plant resource in my country with a wide distribution. Compared to expensive biological agents, this invention has a significant cost advantage and is expected to be developed into a more affordable and accessible anti-psoriasis drug.

Dynamic dosing systems for phototherapy and associated devices, systems, and methods are disclosed herein. In some embodiments, a dynamic dosing phototherapy system can include a self-service phototherapy kiosk (“SPK”) configured to emit UV radiation, a user interface communicatively coupled to the SPK, and a dynamic dosing system communicatively coupled to the user interface and the SPK. The dynamic dosing system can determine initial, user-specific parameters specific to define a first individual phototherapy protocol, and then determine adjustments to the initial parameters and the first individual phototherapy protocol based on user inputs related to erythema response to a previous phototherapy treatment session. The SPK can deliver UV radiation to a user in accordance with the first individual phototherapy protocol and / or an adjusted, second phototherapy protocol that takes into account the user's erythema response.

This invention belongs to the field of cosmetic technology, specifically relating to a composition for improving erythema and photodamage in sensitive skin and its application. The invention provides a composition for improving erythema and photodamage in sensitive skin, which is formulated from 4-tert-butylcyclohexanol, astragalus polysaccharide, ascorbic acid peptides, and supramolecularly refined mullein extract. Through multi-target and multi-pathway integration, it achieves a synergistic effect of "instant soothing, long-lasting moisturizing, barrier repair, and anti-photodamage."

The application discloses application of anti-IGFBP7 antibodies in treating skin diseases, belongs to the technical field of psoriasis treatment, and discloses application of anti-IGFBP7 antibodies in preparation of a medicament for treating psoriasis, wherein the medicament is used for reducing and treating psoriasis-like inflammation by inhibiting expression of IGFBP7 in blood vessels of skin of a psoriasis patient. After the anti-IGFBP7 antibodies are used, psoriasis inflammation is reduced, meanwhile, epidermal thickness of a psoriasis patient is reduced, erythema formation is inhibited, and the generation of scales is reduced. In protecting vascular barrier function and treating psoriasis, the anti-IGFBP7 antibodies have a good medicinal prospect.