14 results about "Melanosome" patented technology

The peptide of the present invention has skin whitening activity by inhibiting melanosome invagination in keratinocytes and promoting melanosome degradation, and can be used as an active ingredient in drugs for treating or preventing hyperpigmentation disorders caused by excessive melanosome deposition or as an active ingredient in skin whitening cosmetics.

The peptides of the present invention exhibit skin whitening activity by inhibiting melanin synthesis in melanocytes and inhibiting melanin body migration. Therefore, the peptide of the present invention can be used as an active ingredient in a medicament for treating or preventing hyperpigmentation diseases caused by excessive deposition of melanin bodies, or as an active ingredient in a cosmetic for skin whitening.

The invention discloses a whitening, anti-wrinkle, firming and soothing multi-effect composition, which is prepared from the following raw material components: nicotinamide, hydroxypropyl tetrahydropyrantriol, p-hydroxyacetophenone, glycerol, 1, 2-pentanediol, 1, 2-hexanediol, a barley extract composition, panthenol, a radix gentianae extract composition, an oat kernel extract composition and the balance of water. The barley extract, the radix gentianae extract and the oat kernel extract are added into the whitening, anti-wrinkle, firming and soothing multi-effect composition, so that melanosome can be inhibited from being transferred to the skin surface, DNA damage caused by UV is repaired, photoimmunosuppression is intervened, elastase and hyaluronidase are inhibited, and the whitening, anti-wrinkle, firming and soothing multi-effect composition has the advantages that the whitening, anti-wrinkle, firming and soothing functions are realized; the face cream prepared from the multi-effect composition for whitening, resisting wrinkles, tightening and relieving has the effects of whitening, resisting wrinkles, tightening and relieving.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and / or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The peptides of the present invention exhibit skin whitening activity by inhibiting melanin body uptake in keratinocytes. The peptide of the present invention can be used as an active ingredient in a medicament for treating or preventing hyperpigmentation diseases caused by excessive deposition of melanin bodies, or as an active ingredient in a cosmetic for skin whitening.

To provide a new technique for inhibiting formation of pigmented spots.SOLUTION: The present invention provides a pigmented spot formation inhibitor including vitamin B6 as an active ingredient.SELECTED DRAWING: None

Hypomelanosis of Ito is a clinical term for patients with mosaic syndromes characterized by skin hypopigmentation and developmental disorders. The genetic causes of these rare diseases remain largely unclear. Here, we report that GNA13 is a new gene that causes Hypomelanosis of Ito. We identified an identical mutation in this gene in four unrelated patients exhibiting pigmentary mosaicism. In depth functional investigations revealed that this is an activatory mutation that alters the cytoskeleton and morphology of melanocytes via a hyperactivation of the RHOA / ROCK signalling pathway. Our results also indicate that this pathology does not necessarily originate from a decreased production of melanin, but can originate from a defect in melanosome transfer to keratinocytes due to cell shape alterations. Thus, our findings suggest for the first time a mechanism by which the clinical symptoms of patients with Hypomelanosis of Ito appear, and pave the path for new therapeutic approaches. Altogether, the present invention relates to a method for treating a patient suffering from hypomelanosis of Ito by administering a ROCK inhibitor and / or RHOA inhibitor.

The peptides of the present invention exhibit skin-whitening activity by inhibiting the absorption of melanosomes in keratinocytes. Therefore, the peptides of the present invention can be used as active ingredients in medicaments for treating or preventing hyperpigmentation caused by excessive melanosome deposition, or as active ingredients in cosmetics for skin whitening.

This invention discloses a regulatory protein that activates melanin in the dermal papilla to promote hair darkening and its preparation method, belonging to the field of biotechnology. The method includes: identifying key endogenous proteins that positively regulate melanin synthesis in dermal papilla cells through multi-omics analysis; constructing a humanized recombinant regulatory protein fused with a membrane-penetrating peptide; loading its coding sequence into a eukaryotic expression vector to achieve local and sustained expression; verifying its melanin-promoting efficacy using a three-dimensional hair follicle organoid model and animal experiments; and formulating a thermosensitive gel for topical application to improve hair follicle-targeted delivery efficiency. This invention aims to address the problems of unclear mechanisms of action and limited efficacy in existing hair-darkening products. It can directly activate the MITF signaling pathway, significantly promote the expression of key enzymes such as TYR and TRP-1, induce melanosome synthesis and deposition, resulting in a hair color darkening rate of over 95%, with long-lasting efficacy and good safety.

The invention relates to the technical field of cosmetics, and discloses a tranexamic acid-containing whitening and spot-fading repairing essence and a preparation method thereof.The provided whitening and spot-fading essence is completely prepared from safe cosmetic raw materials, is free of preservatives, mild, free of irritation and good in whitening and spot-fading effect, and further has a good anti-inflammatory effect; under the synergistic effect of tranexamic acid, alpha-arbutin and lysate of a bifidus yeast fermentation product, the whitening and spot-fading component can rapidly permeate into skin to inhibit the transfer of melanosome, so that the whitening and spot-fading effects are achieved; the tranexamic acid is used for inhibiting the activity of tyrosinase, so that the formation of melanin is effectively blocked, pigmentation is reduced, the decomposition and excretion of melanin are accelerated, the skin is kept tender and soft for a long time, skin cells are activated, the oxidation resistance of the skin is improved, and the effects of whitening and fading spots are achieved; the generation of inflammatory factors is inhibited through the liquorice extract, so that the anti-inflammatory ability of the skin and the oxidation resistance of the skin are improved.

The invention relates to the technical field of cosmeceuticals, in particular to a tightening essence spray. The anti-wrinkle mask is prepared from the following components in percentage by mass: 83.56% of bifidus yeast fermentation product filtrate, 6.5% of an anti-wrinkle agent A, 3.5% of an anti-wrinkle agent B, 2.5% of a preservative, 1.5% of nicotinamide, 1% of an anti-wrinkle agent C, 1% of Wailing enzyme, 0.11% of dipotassium glycyrrhizinate, 0.11% of allantoin, 0.11% of fullerene and 0.11% of hydrolyzed collagen. The anti-wrinkle agent A contains arginine / lysine polypeptide, and the molecular weight of the anti-wrinkle agent A is 1t; the 500Da oligopeptide chain can directly penetrate through the stratum corneum, and is competitively combined with the SNAP-25 protein to block the transmission of neuromuscular signals. The anti-wrinkle agent B contains acetyl hexapeptide-8, and forms a'nerve blocking-muscle relaxing 'closed loop with the anti-wrinkle agent A by inhibiting a calcium ion channel and reducing the depth of dynamic lines, and the effect is remarkable. The nicotinamide in the invention blocks melanosome transfer, activates an AMPK pathway to promote autophagy flow, and accelerates the degradation of generated melanin. The dipotassium glycyrrhizinate inhibits COX-2 inflammatory enzyme, reduces the level of PGE2 inflammatory factors induced by ultraviolet rays, and blocks inflammatory chromaticity.

The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention generally involve compounds produced by a Malassezia yeast, and chemical analogs thereof. In addition to skin brightening applications, the compounds, compositions, and methods of the present invention may be used to modulate melanocyte activity, induce melanocyte apoptosis, agonize an arylhydrocarbon receptor (AhR), improve hyperpigmentation caused by a hyperpigmentation disorder, and modulate melanin production, melanosome biogenesis, and melanosome transfer.

The invention relates to the technical field of cosmetics, in particular to a composition and related application thereof.The composition comprises scutellaria baicalensis root extract and tranexamic acid, melanin synthesis and melanosome maturation are inhibited by regulating melanosome membrane ion channel gene expression, dual inhibition of a melanin synthesis key path is achieved, and the melanin synthesis effect is improved. A remarkable synergistic enhancement effect is shown in the aspect of efficacy; the composition can achieve a remarkable molecular regulation effect only with a low concentration, the irritation risk possibly caused by high-concentration tranexamic acid is avoided while the raw material cost is effectively saved, the safety of the product is remarkably improved, and the composition has the advantages of being good in whitening effect, good in safety and the like.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and / or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.