33 results about "Melanosome" patented technology

The invention relates to the field of cosmetics and provides a co-conveying nano composition of phenylethyl resorcinol. The co-conveying nano composition comprises phenylethyl resorcinol, other skin whitening active components, a nano medicine carrier as well as solvent complex lipid and water, wherein the phenylethyl resorcinol accounts for 0.1-10% of the total mass of the co-conveying nano composition; the other skin whitening active components comprise at least one of an antioxidant, a cutin peeling type active substance, a melanosome transferring inhibition active substance, an anti-glycation active substance and an anti-allergic agent; the nano medicine carrier comprises raw materials of an emulsifier, a Anti-allergic agent and polyhydric alcohols. Due to compounding of different skinwhitening components and carrying of the nano medicine carrier, a remarkable synergetic effect can be achieved, irritation of high-concentration phenylethyl resorcinol can be remarkably reduced, andthe co-conveying nano composition is good in stability, excellent in skin whitening effect, good in water solubility, good in skin permeability and widely applicable to cosmetics.

The invention provides whitening essence containing bearberry extract lipid nanoemulsion. The whitening essence is prepared from a component A, a component B and a component C, wherein the component A comprises arbutin lipid nanoemulsion, antioxidant biological active peptide, vitamin C and the like; the component B is selected from glycerinum, glycerin monostearate, hexadecyl alcohol, squalane, licoflavone, vitamin E, microcrystalline wax and the like; the component C is selected from avocado oil, silicon oil, vitamin E, stearate, hexadecyl alcohol, Vaseline, beeswax, lanum and the like. The whitening essence does not contain chemical ultraviolet absorbent and is a pure natural cosmetic composition by use of plant whitening agent and biological active peptide as functional components, the bearberry extract based whitening essence can reduce the tyrosinase activity and inhibit melanosome maturity, and can be further effectively combined with licoflavone and biological active peptide, thereby achieving good whitening effect.

The invention is directed to a method and composition suitable for skin color modulation. Particularly, the action of D-dopachrome tautomerase on melanogenesis and/or the transfer of melanin from melanosomes in keratinocytes is reduced, thereby resulting in a change in skin color.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The present invention is in the field of personal care compositions; in particular skin lightening compositions. It is believed that niacinamide reduces the melanosome transfer from melanocytes to keratinocytes thereby bringing about skin lightening. However, niacinamide is known to have little or no effect directly on the melanin content in the melanocytes. Thus a composition with multiple modes of action, that combines the reduction of melanosome transfer and the reduction of melanin content in the melanocytes remains to be desired. It is therefore an object of the present invention to provide a composition with synergistic amounts of picolinamide and niacinamide, providing improved melanosome transfer inhibition. It has been found that a synergistic skin lightening effect is obtained when niacinamide is combined with its isomer, picolinamide.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating aylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The invention discloses a preparation method of human hair melanosomes derivatives (HHMs). The preparation method comprises the following steps of step 1, pretreatment: crushing, cleaning and drying human hair; step 2, hydrothermal reaction: carrying out hydrothermal reaction on the pretreated human hair in a NaOH solution; and 3, separation: carrying out centrifugal separation and vacuum drying on a solid sample material obtained after the hydrothermal reaction to obtain HHMs. The invention relates to a preparation method of a human hair melanosomes derivative-lysozyme (HHMs-Lyso) composite material. The preparation method comprises the following steps of uniformly dispersing prepared HHMs into deionized water to obtain a first feed liquid; dispersing lysozyme into deionized water to obtain second feed liquid; and mixing the first feed liquid and the second feed liquid in an isopyknic manner to obtain the HHMs-Lyso. According to the HHMs prepared through the method, MRSA can be efficiently killed by loading Lyso, and meanwhile tissue repair can be promoted through the HHMs.

The invention discloses a cosmetic composition with a whitening effect and application thereof. The cosmetic composition with the whitening effect is prepared from the following components in percentage by mass: 0.1 to 5 percent of nicotinamide, 0.002 to 0.5 percent of tocopherol/tocopherol, 0.002 to 5 percent of sucrose dilaurate and pea extract and 90 to 99.9 percent of cosmetic auxiliary material matrix. According to the cosmetic composition disclosed by the invention, by utilizing a synergistic interaction effect of the nicotinamide, the tocopherol/tocopherol, the sucrose dilaurate and the pea extract, through inhibiting synthesis of melanin and melanosomes, inhibiting melanosome migration, resisting oxidization and resisting damages, caused by free radicals, to skin, resisting ultraviolet damages, realizing comprehensive light protection, strengthening a skin barrier and the like, the cosmetic composition can be used for efficiently and uniformly brightening skin color and enabling the skin to be more and more exquisite and perfect. The cosmetic composition disclosed by the invention is applied to sunscreen cosmetics, so that the whitening effect is expressed and the sunscreen performance of the sunscreen cosmetics also can be improved.

The invention discloses moisturizing water and a preparation method thereof. The moisturizing water is composed of 20-30 wt% of rose water, 3-4 wt% of panthenol, 1-3 wt% of butylene glycol, 1-2 wt% of cynara scolymus leaf extract, 1-2 wt% of glycosphingolipid, 0.1-0.3 wt% of sodium citrate, 0.08-0.12 wt% of citric acid, 0.05-0.15 wt% of a saccharide isomeride, 0.001-0.003 wt% of protease, 0.001-0.003 wt% of protease dextran, 0.0001-0.00015 wt% of a colorant and the balance of water. The moisturizing water combines toning lotion and essence functions, realizes cutin conditioning, permeates and enters skin to activate skin, effectively inhibits the stimulating substances, blocks the formation of melanin, promotes epidermal cell activation, fast discharges melanosomes, relieves redness and inflammation caused by solarization, improves dryness and roughness caused by aging, improves skin brightness from inside to outside, shrinks pores to lock water and preserve moisture, has effects of activation, moisturizing, balance and conditioning and is suitable for all skin types and skin ages.

The invention is directed to a method and composition suitable for skin color modulation. Particularly, the action of D-dopachrome tautomerase on melanogenesis and/or the transfer of melanin from melanosomes in keratinocytes is reduced, thereby resulting in a change in skin color.

The present invention relates to a composition for whitening skin, comprising a dihydro-5-methylfuran-2 (3H)-one derivative having melanogenesis inhibition and melanosome decomposition activity, an isomer thereof, or a pharmaceutically acceptable salt thereof. Specifically, the composition according to the present invention is characterized by inhibiting melanogenesis and promoting melanosome decomposition by the action of a dihydro-5-methylfuran-2 (3H)-one derivative on a melanin biosynthesis signal transduction pathway induced by an alpha-melanocyte stimulant (alpha-MSH), and in that the composition according to the present invention is a composition for inhibiting melanogenesis and promoting melanosome decomposition by means of the action of a dihydro-5-methylfuran-2 (3H)-one derivative on a melanin biosynthesis signal transduction pathway induced by alpha-MSH.