6 results about "Melanosome" patented technology

The peptides of the present invention exhibit skin whitening activity by inhibiting melanin synthesis in melanocytes and inhibiting melanin body migration. Therefore, the peptide of the present invention can be used as an active ingredient in a medicament for treating or preventing hyperpigmentation diseases caused by excessive deposition of melanin bodies, or as an active ingredient in a cosmetic for skin whitening.

The peptides of the present invention exhibit skin whitening activity by inhibiting melanin body uptake in keratinocytes. The peptide of the present invention can be used as an active ingredient in a medicament for treating or preventing hyperpigmentation diseases caused by excessive deposition of melanin bodies, or as an active ingredient in a cosmetic for skin whitening.

To provide a new technique for inhibiting formation of pigmented spots.SOLUTION: The present invention provides a pigmented spot formation inhibitor including vitamin B6 as an active ingredient.SELECTED DRAWING: None

The peptides of the present invention exhibit skin-whitening activity by inhibiting the absorption of melanosomes in keratinocytes. Therefore, the peptides of the present invention can be used as active ingredients in medicaments for treating or preventing hyperpigmentation caused by excessive melanosome deposition, or as active ingredients in cosmetics for skin whitening.

This invention discloses a regulatory protein that activates melanin in the dermal papilla to promote hair darkening and its preparation method, belonging to the field of biotechnology. The method includes: identifying key endogenous proteins that positively regulate melanin synthesis in dermal papilla cells through multi-omics analysis; constructing a humanized recombinant regulatory protein fused with a membrane-penetrating peptide; loading its coding sequence into a eukaryotic expression vector to achieve local and sustained expression; verifying its melanin-promoting efficacy using a three-dimensional hair follicle organoid model and animal experiments; and formulating a thermosensitive gel for topical application to improve hair follicle-targeted delivery efficiency. This invention aims to address the problems of unclear mechanisms of action and limited efficacy in existing hair-darkening products. It can directly activate the MITF signaling pathway, significantly promote the expression of key enzymes such as TYR and TRP-1, induce melanosome synthesis and deposition, resulting in a hair color darkening rate of over 95%, with long-lasting efficacy and good safety.

The invention relates to the technical field of cosmetics, and discloses a tranexamic acid-containing whitening and spot-fading repairing essence and a preparation method thereof.The provided whitening and spot-fading essence is completely prepared from safe cosmetic raw materials, is free of preservatives, mild, free of irritation and good in whitening and spot-fading effect, and further has a good anti-inflammatory effect; under the synergistic effect of tranexamic acid, alpha-arbutin and lysate of a bifidus yeast fermentation product, the whitening and spot-fading component can rapidly permeate into skin to inhibit the transfer of melanosome, so that the whitening and spot-fading effects are achieved; the tranexamic acid is used for inhibiting the activity of tyrosinase, so that the formation of melanin is effectively blocked, pigmentation is reduced, the decomposition and excretion of melanin are accelerated, the skin is kept tender and soft for a long time, skin cells are activated, the oxidation resistance of the skin is improved, and the effects of whitening and fading spots are achieved; the generation of inflammatory factors is inhibited through the liquorice extract, so that the anti-inflammatory ability of the skin and the oxidation resistance of the skin are improved.