92 results about "Tranexamic acid" patented technology

The invention relates to the technical field of skin care products, and discloses an anti-aging and whitening composition and a preparation method thereof.The anti-aging and whitening composition comprises anti-aging and whitening components, whitening synergistic components, moisturizing and repairing components and deionized water, and the anti-aging and whitening components comprise botryine, ergothioneine and Ectoine; wherein the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2 to 2.0) to (0.4 to 0.7) to (1.0 to 1.5); the whitening synergistic component comprises one or more of nicotinamide, glabridin and tranexamic acid; the moisturizing and repairing component is prepared from one or more of sodium hyaluronate, ceramide NP, glycerol and 1, 3-butanediol. Experiments show that the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2-2.0): (0.4-0.7): (1.0-1.5), so that the glassine, the ergothioneine and the ectoine show a remarkable synergistic effect (in some cases, the synergistic index CIlt is 0.85), and the anti-aging and whitening functions of the composition containing the glassine, the ergothioneine and the ectoine are improved.

The invention provides tranexamic acid-glutathione-containing compound emulsifiable paste and a preparation method thereof.W1 / O / W double emulsion phase structural design is adopted, reduced glutathione is encapsulated in an acidic inner water core, an oil phase is stabilized through hydrogenated lecithin and sorbitan sesquioleate, an outer water phase contains tranexamic acid, a layered gel network is constructed, and the tranexamic acid-glutathione-containing compound emulsifiable paste is prepared. A submicron dispersion system with the particle size D50 of 0.30-0.80 microns, the polydispersity index of 0.15-0.25 and the viscosity of 2.0-8.0 Pa seconds is realized, the encapsulation efficiency of glutathione is not lower than 70%, the oxygen content of a head space is not higher than 1.0%, and the encapsulation efficiency of glutathione is not lower than 70%. The three technical contradictions of coupling conflict between a high-yield viscoelastic structure and low-shear damage kernel integrity, coexistence of fresh and cool low-viscosity skin feeling and high-barrier anti-oxidation and anti-leakage and opposite low-surface-activity sensitive skin compatibility and submicron low-PDI dispersion stability are solved; the traditional Chinese medicine composition has wide application values of improving skin color unevenness, fading color spots, brightening skin color, soothing and repairing.

The invention provides a multi-stage synergistic wound repair nanofiber membrane and a preparation method thereof. The composite fiber membrane sequentially comprises an electrostatic spinning pullulan / tannic acid / tranexamic acid nanofiber membrane for promoting the formation of blood clots, a polydopamine / calcium chloride modified electrostatic spinning cellulose acetate membrane with coagulating, antibacterial and repairing effects, and a chitosan composite cellulose non-woven fabric, and the electrostatic spinning pullulan / tannic acid / tranexamic acid nanofiber membrane is a wound surface contact layer. The nanofiber membrane has the functions of a physical hemostasis barrier and continuously releasing regeneration promoting biological signals, and a dynamic hemostasis healing process is formed.

The invention belongs to the technical field of biological medicine, and particularly relates to a reagent for improving ovarian development and a preparation method and application thereof. The reagent for improving ovarian development is prepared by mixing the following raw materials in parts by weight: 20-30 parts of N-acetylcysteine; 5 to 10 parts of tranexamic acid; 3 to 8 parts of creatine; and 3000 parts of water. According to the reagent, the mRNA expression of PKD1P6 and follicle stimulating hormone receptors (FSHR) in ovarian tissues is up-regulated, the activity and functions of cumulus granular cells are enhanced, and apoptosis of the cumulus granular cells is inhibited, so that the effects of effectively promoting follicle development and inhibiting the apoptosis of the cumulus granular cells are achieved.

The present invention relates to solid compositions. The present invention addresses the problem of providing a solid composition containing at least one substance selected from the group consisting of tepiperidine and salts thereof, and at least one substance selected from the group consisting of tranexamic acid and salts thereof, in which the dissolution of tepiperidine is improved. [Solution] A solid composition containing the following components: (A) at least one substance selected from the group consisting of tepiperidine and salts thereof; (B) at least one substance selected from the group consisting of tranexamic acid and salts thereof; and (C) at least one compound selected from the group consisting of ibuprofen and salts thereof, in which the solid composition does not include a solid composition comprising levocetirizine or loratadine.

The invention discloses an anti-oxidation, whitening and brightening composition as well as a preparation method and application thereof. The anti-oxidation, whitening and brightening composition is prepared from the following components in parts by weight: 2 to 6 parts of nicotinamide, 0.5 to 5 parts of tranexamic acid, 1 to 5 parts of nonapeptide-1 solution, 0.5 to 1 part of tetrahydromethylpyrimidine carboxylic acid, 0.5 to 2 parts of pink red plum compound essence, 0.01 to 0.5 part of hydroxyethyl piperazine ethanesulfonic acid, 0.01 to 0.5 part of glabridin and 0.0001 to 0.2 part of glutathione. According to the invention, the composition prepared from nicotinamide, tranexamic acid, nonapeptide-1, tetrahydromethylpyrimidine carboxylic acid, pink-red plum composite essence, hydroxyethyl piperazine ethanesulfonic acid, glabridin and glutathione is prepared into the essence, and the clearance rate of the essence to ABTS free radicals reaches 58% or above, which shows that the essence has very good antioxidant ability; the cell tyrosinase activity inhibition rate of the composition under the concentration of 1.2% (v / v) reaches 51% or above, which shows that the composition has very good whitening and brightening effects.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

This invention provides tranexamic acid liposomes, their preparation method, and applications, relating to the field of nanoliposome technology. This invention utilizes a simple process to prepare tranexamic acid liposomes by rationally combining the ratios of tranexamic acid, phospholipids, and cholesterol. This invention achieves high loading capacity and high loading rate for the active ingredient tranexamic acid, maintaining its stability for a long time under various temperature conditions. The tranexamic acid liposomes prepared by this invention have a particle size between 10-50 nm, enabling better penetration into the stratum corneum and targeting the basal layer of the skin, providing a long-lasting and stable effect. Compared to liposomes prepared by other processes, they exhibit excellent transdermal permeability and skin retention, which is more conducive to the efficacy of the active ingredient, significantly improving its bioavailability and resulting in a greater skin-lightening effect.

A patch composition for targeting herpes virus comprising the following ingredients: a patch base, trisodium phosphate, malic acid, sorbitol, sodium benzoate, cellulose gum, peppermint, sodium saccharin, naringin, wind wheel grass extract, xanthan gum, polyethylene glycol-8, calcium carbonate, hydroxyethyl cellulose, hydroxypropyl guar gum, sodium nitrate, hydrated silica, sodium lauryl sulfate, strontium chloride hexahydrate, tranexamic acid, two-faced needle extract, sodium monofluorophosphate, sea salt, potassium nitrate, sodium chloride, and purified water q.s.

The present invention provides a solid composition containing: crystals composed of ibuprofen and tranexamic acid; and a surfactant.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

A method for enhancing solubility of tranexamic acid comprising the following steps:a) Initially dissolving tranexamic acid in water;b) Measuring a pH value of the solution obtained in Step (a);c) Addition of a strong acid (that dissociates completely in water) to the solution obtained in Step (a) and simultaneously monitoring the decrease in the pH value of the solution until approximately pH 4.5 or less than pH 4.5 is reached, to increase solubility of tranexamic acid;d) Addition of tranexamic acid to reach the pH value of the solution obtained in Step (c) above the pH 2.0; ande) Repeating Steps (c) and (d) until a desired amount of tranexamic acid is added to the solution of Step (a), that is a desired concentration of tranexamic acid in the final solution is reached.

The invention belongs to the technical field of medical dressings, and discloses a recombinant human collagen combined nano-silver ionic liquid-containing dressing and a preparation method thereof. The invention discloses a liquid dressing. Comprising the following raw materials: 8 to 15 parts of polyvinyl alcohol, 3 to 6 parts of calcium alginate, 1 to 3 parts of polydimethylsiloxane, 0.1 to 0.5 part of an antibacterial agent, 2 to 5 parts of bioactive protein, 1 to 4 parts of sodium hyaluronate, 2 to 5 parts of chitosan, 0.5 to 2 parts of tranexamic acid, 0.3 to 1 part of polypeptide, 0.2 to 0.8 part of an anti-inflammatory agent, 0.5 to 1.5 parts of ethylhexylglycerin, 10 to 20 parts of glycerin, 0.5 to 1.2 parts of carbomer, 0.1 to 0.3 part of biguanide hydrochloride and 40 to 60 parts of deionized water. The comprehensive improvement of the liquid dressing on the aspects of antibiosis, repair promotion, stability and safety is realized. All the components are matched to achieve the effects of broad-spectrum antibacterial property, healing time shortening and activity protection. Temperature gradient control, microwave activation and high-pressure homogenization are adopted in the process, the compatibility of all the raw materials is improved, the dressing is stable in physical performance, free of layering during storage and high in safety, and the requirements for skin wound protection and repair are met.

This invention belongs to the field of biopharmaceutical technology and discloses a tranexamic acid sustained-release composition, its preparation process, and its application. By weight, the composition comprises 100-120 parts tranexamic acid, 14-18 parts sustained-release material, 5-8 parts magnesium stearate, 2-5 parts colloidal silica, and 3-5 parts polyvinyl alcohol. The sustained-release material is selected from a combination of hydroxypropyl cellulose and ethyl cellulose, or a combination of hydroxypropyl methyl cellulose and microcrystalline cellulose, or a combination of sodium carboxymethyl cellulose and hydrogenated vegetable oil. This invention utilizes the synergistic effect of the sustained-release material and the synergistic effect between the sustained-release material and polyvinyl alcohol to maintain zero-order or first-order release of the drug, achieving a steady-state blood drug concentration and prolonging the duration of action, thereby achieving a good sustained-release effect.

The invention discloses a postoperative blackening inhibiting and brightening repairing body lotion and a preparation method thereof, the postoperative blackening inhibiting and brightening repairing body lotion comprises the following components by mass: 1-3% of tranexamic acid, 2-5% of nicotinamide, 3-6% of an aloe vera extract, 0.5-2% of menthol, 0.1-0.5% of an anti-allergy agent, 5-10% of a humectant, 2-4% of an emulsifier, 0.5-1% of a thickener, 0.05-0.2% of a pH regulator, 0.3-0.8% of a preservative, and the balance of deionized water. The invention has the following beneficial effects: by adding tranexamic acid into the formula, the activity of tyrosinase and melanocyte proliferation can be inhibited, melanin generation can be reduced from the source, nicotinamide can block melanin from being transferred to cuticle, and nicotinamide and tranexamic acid generate a synergistic effect, so that the blackness inhibition effect can be enhanced; the anti-inflammatory and moisturizing functions can be provided, then the postoperative skin inflammation reaction is reduced, menthol added in the formula can generate cooling feeling when activated, postoperative pain and scorching discomfort are effectively relieved, and the anti-allergy agent can reduce the skin allergy risk and improve the product safety.

This invention discloses a multi-repair and anti-pigmentation composition and its preparation method, including the pre-preparation of a sustained-release carrier, aqueous phase preparation, pre-dissolution of active ingredients, emulsification and mixing, and cooling treatment. In use, the raw materials are pre-treated by adding deionized water, glycerin, sodium hyaluronate, and disodium EDTA to a mixing tank and stirring evenly at 300-400 r / min and 45-50℃ until completely dissolved, obtaining an aqueous matrix. A small amount of deionized water is added and stirred at 500-600 r / min and 35-40℃. Sustained-release microspheres are prepared by spray drying and set aside. The remaining active ingredients, such as nicotinamide, tranexamic acid, and repairing components (such as Centella asiatica extract), are pulverized and passed through an 80-mesh sieve to remove impurities and set aside. The aqueous matrix is ​​cooled to 30-35℃, and a thickener composed of xanthan gum and hydroxyethyl cellulose is added. The mixture is stirred at low speed (200-300 r / min) for 15-20 minutes until the system is homogeneous and free of particles.

The present invention relates to solid compositions. The present invention addresses the problem of providing a solid composition containing ibuprofen in which changes in properties are suppressed. [Solution] A solid composition comprising the following components: (A) ibuprofen; (B) at least one substance selected from the group consisting of tepiperidine and salts thereof; and (C) at least one compound selected from the group consisting of tranexamic acid and salts thereof, in which the solid composition does not include a solid composition containing levocetirizine or loratadine.

The invention discloses a soluble microneedle array transdermal drug delivery freckle-removing mask and a preparation method of the soluble microneedle array transdermal drug delivery freckle-removing mask. The mask comprises a backing layer and a soluble micro-needle array arranged on the backing layer, the micro-needle array is composed of a needle tip and a base, and the needle tip comprises a freckle-removing active component, a nano-carrier material, a micro-needle matrix material and a stabilizer. The freckle-removing active components comprise tranexamic acid, sodium ascorbyl phosphate, Maojian green tea extract, licoflavone and nicotinamide; the nano carrier material is selected from hydroxyl cyclodextrin, chitosan nanoparticles and alginic acid-chitosan nanoparticles; the microneedle matrix material comprises hyaluronic acid, polyvinylpyrrolidone and polyvinyl alcohol. Through combination of a nano-carrier technology and a micro-needle system, the drug loading capacity, stability and transdermal efficiency of freckle-removing active ingredients are remarkably improved, and the freckle-removing micro-needle has the advantages of being good in freckle-removing effect, painless, noninvasive, convenient to use and the like, and is suitable for prevention and treatment of chloasma, freckles, hyperpigmentation after inflammation and other pigmented skin diseases.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

Concentrated tranexamic acid compositions suitable for intramuscular administration via auto-injector are provided. The concentrated tranexamic acid compositions enable the use of a syringe and an auto-injector to facilitate rapid, reliable, and simple self or buddy administration, under extreme duress on the battlefield, by minimally trained users. Methods of treating non-compressible hemorrhage are also provided. Kits and auto-injectors comprising the tranexamic acid compositions are further provided.

The invention discloses a small nucleic acid freckle-removing essence, which is carefully matched with active ingredients such as siRNA, NARDOSTACHYS CHINENSIS extract, nicotinamide, ascorbyl glucoside, tranexamic acid and the like, not only can block the generation of melanin from the source, but also can promote the metabolism of skin, accelerate the metabolism of generated melanin, and achieve internal and external synergism, so that the freckle-removing essence has the effects of removing freckle, removing freckle and removing freckle. A good removing effect is achieved on freckles, chloasma and other color spots.

This invention relates to a highly penetrating soluble microneedle patch containing small molecule PDRN. It comprises a functional needle body and a base. The functional needle body is prepared from components comprising the following parts by weight: 4-7 parts sodium hyaluronate, 1-3 parts PDRN, 1-2 parts p-hydroxyacetophenone, 1-3 parts hydroxypropyl cellulose, 2-4 parts glutathione, 0.1-0.3 parts tranexamic acid, and 5-7 parts centella asiatica. The base is prepared from a polymer matrix material. This invention is the first to add PDRN to a soluble microneedle patch, using PDRN of different molecular weights and concentrations to prepare soluble microneedle patches with different penetration properties. This effectively solves the problems of insufficient hardness, poor penetration, and poor penetration rate of existing soluble microneedle patches, enabling it to penetrate skin with different stratum corneum thicknesses and making it applicable to various skin conditions with a wide range of applications.

The invention relates to a high-efficiency hemostatic antibacterial gel dressing, which is prepared from the following raw materials: 4-carboxyphenylboronic acid-based chitosan, drug aldehyde, methacrylic acid esterified gelatin and tranexamic acid, wherein the 4-carboxyphenylboronic acid-based chitosan and the methacrylic acid esterified gelatin are dissolved in water to form a solution A; protocatechuic aldehyde and tranexamic acid are dissolved in water to form a solution B, the solution A and the solution B are rapidly and uniformly mixed to form a pre-injection solution before treatment, the pre-injection solution is injected to the surface of a wound surface so that the dressing can be cured and formed in situ, after forming, the dressing can effectively adhere to the skin and release drugs, rapid hemostasis and antibiosis are achieved, and the dressing can be degraded in about 10 days in a physiological solution environment; the gel dressing can be widely applied to treatment of different trauma wounds.

The present invention relates to solid compositions. The present invention addresses the problem of providing a novel solid composition. The solution of the invention is to provide a solid composition containing crystals formed by ibuprofen and tranexamic acid, and licorice.

The application provides a tranexamic acid-glutathione compound cream and a preparation method thereof, adopts a W1 / O / W double emulsion phase structure design, encapsulates reduced glutathione in an acidic inner water core, stabilizes an oil phase by using hydrogenated lecithin and sorbitan sesquioleate, and constructs a lamellar gel network in an outer water phase containing tranexamic acid, so as to realize a sub-micron dispersion system with a particle size D50 of 0.30-0.80 microns, a polydispersity index of 0.15-0.25 and a viscosity of 2.0-8.0 Pa seconds, the encapsulation rate of glutathione is not less than 70%, and the headspace oxygen content is not higher than 1.0%, three technical contradictions of a high yield viscoelastic structure and a low shear damage inner core integrity coupling conflict, a smooth low skin feeling and a high barrier anti-oxidation and anti-leakage coexistence problem and a low surface activity sensitive skin compatibility and a sub-micron low PDI dispersion stability are solved, and the application has wide application values of improving uneven skin color, lightening color spots, brightening skin color and soothing and repairing.

The invention discloses an application of a compound gel preparation in preparation of a product for treating chloasma. The compound gel disclosed by the invention is prepared from polypeptide gel capable of opening tight connection of skin through a self-assembly method. Finally, the hydrogel with certain flowability is formed. The polypeptide gel formed by the invention can penetrate through the surface layer of the skin, tranexamic acid, vitamin C and reduced glutathione are transferred to the basal layer of the skin through one-time operation, and then tranexamic acid is competitively combined with tyrosinase to inhibit the activity of the tyrosinase, so that the formation of melanin is reduced; the vitamin C inhibits the formation of melanin by reducing the formation of o-quinone and reducing oxidized melanin; the reduced glutathione is used as an antioxidant component, can inhibit the generation of free radicals, helps to stabilize the skin and restore the skin whiteness, can be used for treating chloasma, and provides a new solution for the field of skin health treatment.

Disclosed are compositions comprising tranexamic acid particles having a D 90 of 5.0 µm or less, methods of making the compositions, uses of the compositions, and devices containing the compositions.

The invention provides a recombinant collagen patch for treating facial dermatitis and eczema and fading pigmentation and a preparation method of the recombinant collagen patch. The application comprises a base material layer and a functional composition loaded on the base material layer, wherein the functional composition comprises recombinant human collagen III, an anti-inflammatory active component and a whitening active component. Wherein the anti-inflammatory active component is a compound of ganoderma sinensis spore powder zymolyte, dipotassium glycyrrhizinate and asiaticoside in a specific mass ratio, and the whitening active component is an alpha-arbutin-ferulic acid condensate and a compound of tranexamic acid and glabridin in a specific mass ratio. And the base material layer is alginate-sodium carboxymethyl cellulose composite hydrogel which is modified by gamma-ray irradiation. Through the synergistic effect of all the active ingredients and the optimized preparation process, the multiple effects of resisting inflammation, repairing a barrier and fading hyperpigmentation are achieved, and the product is good in biocompatibility and remarkable in effect.

The invention discloses a cosmetic composition with blue light resistance and multiple skin protection effects and application of the cosmetic composition. Comprising the following components: water, butanediol, glycerol, nicotinamide, erythritol, hexanediol, p-hydroxyacetophenone, alpha-arbutin, tranexamic acid, glycosylglycerol, carbomer, hydrolyzed collagen, a ganoderma lucidum extract, allantoin, euglena tiny polysaccharide, carnosine and 3-o-ethyl ascorbic acid. The synergistic relationship of various active ingredients in blue light-induced injury is researched, and it is found for the first time that the cosmetic composition has remarkable effects in the aspects of reducing blue light-induced oxidation pressure, relieving chromatosis, improving skin barrier stability and improving dark skin color; the cosmetic composition is used for preparing cosmetics with the effects of resisting blue light, whitening and brightening, and shielding and repairing, and can effectively resist blue light damage and improve the comprehensive state of skin.

This invention discloses a tetrahedral framework nucleic acid complex carrying tranexamic acid and its applications. The complex is formed by mixing tetrahedral framework nucleic acid and tranexamic acid; the molar ratio of tetrahedral framework nucleic acid to tranexamic acid is 1:(150-170). Research shows that the tetrahedral framework nucleic acid can successfully bind to tranexamic acid and exhibits a significant synergistic effect; the complex can effectively reduce melanin content, inhibit skin pigmentation, and protect skin structure, thus improving skin pigmentation-related diseases. This invention provides a novel tranexamic acid delivery strategy, offering a new technical means for developing products that effectively improve skin pigmentation and protect skin structure.