379 results about "Tranexamic acid" patented technology

A composition which comprises (i) tranexamic acid or a salt thereof, (ii) L-cysteine, a derivative thereof or a salt thereof and, as occasion demands, (iii) L-ascorbic acid, a derivative thereof or a salt thereof.

Tranexamic acid formulated in an oral dosage form with at least one agent that decreases tranexamic acid release in the stomach. Such formulations minimize nausea, vomiting, and other adverse gastric effects that may accompany tranexamic acid therapy, for example, to treat heavy menstrual bleeding. One embodiment is an extended release formulation with waxes, polymers, etc. that prevent a bolus release of tranexamic acid in the stomach. An alternative embodiment is a delayed release formulation with polymers that prevent release of tranexamic acid in the acid environment of the stomach and delay its release until the formulation reaches the less acid environment of the intestines. Such formulations enhance patient compliance with therapy because adverse effects of tranexamic acid therapy are reduced.

The invention discloses a cosmetic and a preparation method thereof. The cosmetic is prepared from five components of A, B, C, D and E. The cosmetic is composed of thirty raw materials including deionized water, hydroxyethyl cellulose, allantoin, carbopol U20, propanediol, 1,3-butanediol, sodium hyaluronate, an aloe vera extract, a natto extract, asiaticoside, vitamin C, bisabolol, an amino acid humectant, D-panthenol, VC ethyl ether, nicotinamide, glabridin, tranexamic acid, ceramide, algal polysaccharide, glucan, dipotassium glycyrrhizinate, an epidermal growth factor (EGF), triethanolamine, isothiazolinone, essence, squalane, jojoba oil, vitamin E oil and crystal sparkling pearl powder. The cosmetic has the functions of making skins fine and smooth, brightening the skins, repairing sensitive skins, controlling oil, toning skins and modifying skin blemishes, has no side effect or no dependence, and does not threaten health of a human body.

Disclosed are delayed release oral tranexamic acid formulations and methods of treatment therewith.

Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.

Disclosed are immediate release oral tranexamic acid formulations and methods of treatment therewith.

Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.

Process for the industrial synthesis of compounds of formula (I): wherein R and R' which are the same or different, each represent linear or branched (C1-C6)alkyl. Application to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.

The invention discloses a medicinal sustained-release and hemostatic composition and a preparation method thereof, which belong to the technical field of novel hemostatic materials. The medicinal sustained-release and hemostatic composition comprises the composition of a medicament-loaded chitosan microsphere, chitosan and hyaluronic acid, wherein the medicament-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The novel hemostatic composition is prepared by using chitosan and the hyaluronic acid as a main hemostatic matrix, combining chitosan medicament sustained-release microsphere composite medicament, namely tranexamic acid, utilizing the special property of the chitosan with a hemostatic function and a medicament sustained-release function, and adopting the composition of the hyaluronic acid with good hemostatic function and high biocompatibility and the chitosan as the main matrix. The novel hemostatic composition has the advantages of stopping bleeding rapidly and releasing medicament/factors continuously and stably in a certain time, along with great economic and social benefits.

For defects that existing hemostasis research and products cannot intelligently perform self-propelling or cannot be driven to forward deep in the wound under the action of external field force, the invention provides a preparation method for a janus structure based rapid hemostatic agent having a directional propulsion function. The preparation method includes performing esterification on microporous starch to unidirectionally grow calcium carbonate particles so as to obtain esterified microporous starch/calcium carbonate Janus particles; fixedly assembling thrombin on the surfaces of the esterified microporous starch/calcium carbonate Janus particles to obtain esterified microporous starch/calcium carbonate Janus particles assembled with the thrombin; mixing the esterified microporous starch/calcium carbonate Janus particles assembled with the thrombin and protonated tranexamic acid powder so as to obtain the janus structure based rapid hemostatic agent having a directional propulsion function. Through the formation of the biphasic heterogeneous Janus structure, the unidirectional and intelligent self-propulsion of hemostatic starch can be realized by cooperating with the protonated tranexamic acid, so that rapid three-dimensional hemostasis on deep wounds, penetrating wounds and irregular wounds such as aortic / venous rupture can be realized.

The invention belongs to the technical field of cosmetics, and discloses a skin care substrate with long acting moisturizing and whitening effects and preparation and application of skin care substrate. The skin care substrate is prepared from the following components in mass percent: 10%-20% of tremella polysaccharide, 5%-10% of glycosphingolipid, 10%-20% of saccharide isomerate, 5%-10% of nicotinamide, 3%-6% of alpha-arbutin, 3%-6% of tranexamic acid, 1%-3% of ADS-Oligonol and balance of water. The skin care substrate disclosed by the invention has obvious long acting moisturizing and skin whitening effects and can make the skin moisturized and bright white by persistent use.

A composition for the prevention or alleviation of pigmentation which can produce the higher effect of preventing or alleviating pigmentation. The composition for the prevention or alleviation of pigmentation comprises a combination of (A) at least one member selected from the group consisting of adenosine 5′-monophosphate and salts thereof with (B) at least one member selected from the group consisting of arbutin, ellagic acid, 4-alkylresorcinols, linoleic acid, tranexamic acid, salts of these, Chamomilla recuita extract, and Ubiquinone.

The invention discloses a moisturizing, whitening, acne removing, grease controlling and relieving skin beautifying composition. The composition is mainly prepared from the following raw materials: raspberry ketone glucoside, arbutin, matrine, fructo-oligosaccharide, tea tree oil, dipotassium glycyrrhizinate, an extracting solution of leaf of Tasmanian bluegum, tea polyphenol, a peony root extract, tremella polysaccharide, hyaluronic acid with low molecular weight, hyaluronic acid with high molecular weight, transparent xanthan gum, zinc gluconate, Carbomer 940, hydroxyethyl cellulose, 1,3-butanediol, nicotinamide, D-panthenol, tranexamic acid, vitamin C ethyl ether, triethanolamine, an emulsifier, water, and the like. The moisturizing, whitening, acne removing, grease controlling and relieving skin beautifying composition has the beneficial effects that the composition is rich in plant essence, is reasonable in proportioning and can achieve the effects of effectively comforting and smoothening pores, cleaning hair follicles, balancing grease excretion, promoting wound healing and ensuring no pockmarks after healing and low recurrence probability; besides, the composition is also rich in moisturizing ingredients, so that the skins can be hydrated and bright, fine lines can be reduced and smooth and fair skins can be restored after the composition is used for a long term.

The invention provides whitening essence and a preparation method thereof. The whitening essence consists of the following components of glycerine, 1,3-butanediol, sodium hyaluronate, EDTA-2Na, polyglycerol-10, sodium polyacrylate, xanthan gum, hydroxyacetophenone, dipotassium glycyrrhizinate, hydrolyzed sclerotium gum, gluconic acid sodium salt, glycereth-26, caprylhydroxamic acid, glycerol caprylate, 3-o-ethyl ascorbic acid, tranexamic acid, ceramide, phenethyl resorcinol, diglucosyl gallic acid and water. The whitening essence disclosed by the invention can refrain conversion of tyrosine tomelanin before the tyrosine is in preparation of conversion to the melanin, so that the activity of the tyrosinase is also high, generation of more melanin cannot be caused, and transfer of skin melanin can also be restrained. Besides, the whitening essence has powerful antioxidant ability, has light protection effects on skin, can control dermatitis, and is a whitening product most comprehensivein action mechanism at present, so that whitening effects can be achieved.

A bloating ameliorant, a lymphatic vessel activator and a VEGFC production promoter comprising a tranexamic acid amide derivative and/or salt thereof.

The invention provides toothpaste with hemostasis and gum protection functions and a preparation method of the toothpaste. The toothpaste comprises, by weight, 0.03-1.0% of panax notoginseng extract, 30-55% of abrasives, 15-30% of wetting agents, 0.6-1.5% of adhesives, 2-2.7% of foaming agents and water. The preparation method includes the steps of mixing panax notoginseng saponins, tranexamic acid, the abrasives, the wetting agents, the adhesives and the water according to the weight percentage, conducting stirring and grinding for 25-40 minutes, conducting vacuum degassing, and obtaining a toothpaste body. By means of the combined application of the panax notoginseng extract and tranexamic acid, the toothpaste can have the enhanced hemostasis and gum protection functions.

The invention discloses a process for producing tranexamic acid, wherein p-aminomethyl benzoic acid raw material is hydrogenised, and the hydrogenization liquid is neutralized to pH7-7.5 through barium carbonate, after filtering, the solution is condensed to 10 gram molecule p-aminomethyl benzoic acid reaction liquid of 5l, then charge raw materials by the portion ratio of ammonia cyclohexyl-methane carboxyl acid sym-form liquid (V) : barium hydroxide (W) : water (W) : ethanol (V) = 1:0.5-1.5:2-3.5:1.5-3, elevating the temperature to 230-260 deg. C, the pressure being 2.9-4.8.0Mpa, reacting time being 7.5-10 hours, after reaction charging water and elevating the temperature to 60-70 deg. C, neutralizing through carbon dioxide till pH=6-7.5, filtering and adjusting pH=5.2-5.5 through sulfuric acid, stewing, charging right amount activated charcoal, boiling and decolorizing, filtering, filter cake washing, condensing, charging ethanol for recrystallization, cooling down to 8-12 deg. C, filtering, washing crystallization by ethanol, filter cake drying to obtain tranexamic acid.