147 results about "Tranexamic acid" patented technology

Provided are a whitening and freckle-removing composition, a gel, a preparation method therefor, and a use thereof, relating to the technical field of skin-care products. The whitening and freckle-removing composition comprises tranexamic acid, nicotinamide, 4-butylresorcinol, licorice extract, 3-o-ethyl ascorbic acid, and glutathione. For the whitening composition, by inhibiting the activity of tyrosinase, blocking the transfer of melanin from melanocytes to keratinocytes, and inhibiting the formation and accumulation of melanin by means of multiple mechanisms including oxidation resistance, and by means of the synergistic action of all components, cosmetic benefits of whitening and freckle-removing are achieved. The whitening and freckle-removing gel has a simple preparation method, has a mild and non-sensitizing formula, is safe and non-irritating, and is suitable for large-scale production and application.

The invention relates to the technical field of skin care products, and discloses an anti-aging and whitening composition and a preparation method thereof.The anti-aging and whitening composition comprises anti-aging and whitening components, whitening synergistic components, moisturizing and repairing components and deionized water, and the anti-aging and whitening components comprise botryine, ergothioneine and Ectoine; wherein the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2 to 2.0) to (0.4 to 0.7) to (1.0 to 1.5); the whitening synergistic component comprises one or more of nicotinamide, glabridin and tranexamic acid; the moisturizing and repairing component is prepared from one or more of sodium hyaluronate, ceramide NP, glycerol and 1, 3-butanediol. Experiments show that the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2-2.0): (0.4-0.7): (1.0-1.5), so that the glassine, the ergothioneine and the ectoine show a remarkable synergistic effect (in some cases, the synergistic index CIlt is 0.85), and the anti-aging and whitening functions of the composition containing the glassine, the ergothioneine and the ectoine are improved.

The invention discloses a preparation method and application of autologous fibrin glue, and belongs to the field of biomedical materials. The preparation method comprises the following five steps: collecting autologous venous blood, adding a sodium citrate anticoagulant with the volume ratio of 1: (8-12), and storing at 4-6 DEG C for not more than 2 hours; performing step-by-step centrifugation at the speed of 1500 to 2000 r / min and the speed of 3500 to 4000 r / min to obtain a fibrinogen concentrate; the thrombin-calcium chloride activation solution A and the tranexamic acid activation solution B are mixed according to the ratio of 1: (2-3) to form a composite activation system; mixing the two components according to a mass ratio of 1: (0.8-1.2), and reacting at 25-37 DEG C for 3-5 minutes to form colloid; and pre-freezing at-40 to-60 DEG C, performing vacuum freeze-drying, and storing at 4-8 DEG C. During application, the colloid can be coated on an operation wound surface after being redissolved, or mixed with a growth factor to prepare a dressing for covering a chronic wound surface. The colloid is high in purity, stable in coagulation time, long in storage period, suitable for scenes such as surgical hemostasis and the like, and high in clinical value.

The invention provides tranexamic acid-glutathione-containing compound emulsifiable paste and a preparation method thereof.W1 / O / W double emulsion phase structural design is adopted, reduced glutathione is encapsulated in an acidic inner water core, an oil phase is stabilized through hydrogenated lecithin and sorbitan sesquioleate, an outer water phase contains tranexamic acid, a layered gel network is constructed, and the tranexamic acid-glutathione-containing compound emulsifiable paste is prepared. A submicron dispersion system with the particle size D50 of 0.30-0.80 microns, the polydispersity index of 0.15-0.25 and the viscosity of 2.0-8.0 Pa seconds is realized, the encapsulation efficiency of glutathione is not lower than 70%, the oxygen content of a head space is not higher than 1.0%, and the encapsulation efficiency of glutathione is not lower than 70%. The three technical contradictions of coupling conflict between a high-yield viscoelastic structure and low-shear damage kernel integrity, coexistence of fresh and cool low-viscosity skin feeling and high-barrier anti-oxidation and anti-leakage and opposite low-surface-activity sensitive skin compatibility and submicron low-PDI dispersion stability are solved; the traditional Chinese medicine composition has wide application values of improving skin color unevenness, fading color spots, brightening skin color, soothing and repairing.

The invention provides a multi-stage synergistic wound repair nanofiber membrane and a preparation method thereof. The composite fiber membrane sequentially comprises an electrostatic spinning pullulan / tannic acid / tranexamic acid nanofiber membrane for promoting the formation of blood clots, a polydopamine / calcium chloride modified electrostatic spinning cellulose acetate membrane with coagulating, antibacterial and repairing effects, and a chitosan composite cellulose non-woven fabric, and the electrostatic spinning pullulan / tannic acid / tranexamic acid nanofiber membrane is a wound surface contact layer. The nanofiber membrane has the functions of a physical hemostasis barrier and continuously releasing regeneration promoting biological signals, and a dynamic hemostasis healing process is formed.

The invention belongs to the technical field of biological medicine, and particularly relates to a reagent for improving ovarian development and a preparation method and application thereof. The reagent for improving ovarian development is prepared by mixing the following raw materials in parts by weight: 20-30 parts of N-acetylcysteine; 5 to 10 parts of tranexamic acid; 3 to 8 parts of creatine; and 3000 parts of water. According to the reagent, the mRNA expression of PKD1P6 and follicle stimulating hormone receptors (FSHR) in ovarian tissues is up-regulated, the activity and functions of cumulus granular cells are enhanced, and apoptosis of the cumulus granular cells is inhibited, so that the effects of effectively promoting follicle development and inhibiting the apoptosis of the cumulus granular cells are achieved.

The invention discloses a whitening and spot-fading composition and application thereof, and belongs to the technical field of cosmetics. The whitening and spot-fading composition is prepared from the following components in percentage by mass: 0.1 to 5.0 percent of nicotinamide, 0.0001 to 3.0 percent of tranexamic acid, 0.0001 to 1.0 percent of glycyrrhiza glabra root extract, 0.0001 to 0.4 percent of phenethyl resorcinol, 0.0001 to 2.0 percent of ascorbyl tetraisopalmitate, 0 to 1.0 percent (not including 0) of radix gentianae extract, 0.15 to 4.0 percent of emulsifier, 0.1 to 2.5 percent of antioxidant and the balance of water. By matching with various whitening active ingredients, the comprehensive whitening, brightening and skin improving effects are realized in the aspects of inhibiting melanin generation, blocking melanin transfer, accelerating melanin metabolism and the like; the combination of the specific emulsifier and the thickener can effectively improve the component stability of the composition. The composition is mild in performance, free of irritation to skin and good in market value.

The present invention relates to solid compositions. The present invention addresses the problem of providing a solid composition containing at least one substance selected from the group consisting of tepiperidine and salts thereof, and at least one substance selected from the group consisting of tranexamic acid and salts thereof, in which the dissolution of tepiperidine is improved. [Solution] A solid composition containing the following components: (A) at least one substance selected from the group consisting of tepiperidine and salts thereof; (B) at least one substance selected from the group consisting of tranexamic acid and salts thereof; and (C) at least one compound selected from the group consisting of ibuprofen and salts thereof, in which the solid composition does not include a solid composition comprising levocetirizine or loratadine.

The invention discloses an anti-oxidation, whitening and brightening composition as well as a preparation method and application thereof. The anti-oxidation, whitening and brightening composition is prepared from the following components in parts by weight: 2 to 6 parts of nicotinamide, 0.5 to 5 parts of tranexamic acid, 1 to 5 parts of nonapeptide-1 solution, 0.5 to 1 part of tetrahydromethylpyrimidine carboxylic acid, 0.5 to 2 parts of pink red plum compound essence, 0.01 to 0.5 part of hydroxyethyl piperazine ethanesulfonic acid, 0.01 to 0.5 part of glabridin and 0.0001 to 0.2 part of glutathione. According to the invention, the composition prepared from nicotinamide, tranexamic acid, nonapeptide-1, tetrahydromethylpyrimidine carboxylic acid, pink-red plum composite essence, hydroxyethyl piperazine ethanesulfonic acid, glabridin and glutathione is prepared into the essence, and the clearance rate of the essence to ABTS free radicals reaches 58% or above, which shows that the essence has very good antioxidant ability; the cell tyrosinase activity inhibition rate of the composition under the concentration of 1.2% (v / v) reaches 51% or above, which shows that the composition has very good whitening and brightening effects.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The invention provides a whitening composition containing a jasmine extract as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The whitening composition is prepared from the following components in parts by weight: 1 to 10 parts of nicotinamide; 0.1 to 5 parts of taurine; 0.1 to 3 parts of lecithin; 0.01 to 2 parts of inositol; 0.01 to 1 part of ceramide NP; 0.1 to 3 parts of tranexamic acid; 0.01-2 parts of glutathione, 0.1-5 parts of a jasmine flower lactobacillus fermentation extract and 20-60 parts of water. By controlling the types and mass ratio of the specific components, especially the mass ratio of lecithin to tranexamic acid, inositol to glutathione, and nicotinamide to taurine to jasmine lactic acid bacteria fermentation extract, the obtained composition not only can inhibit melanin generation and transport, but also can promote permeation of effective components, so that the anti-aging effect of the composition is improved, and the anti-aging effect of the composition is improved. The content of effective components in the skin is increased, so that the absorption effect and the bioavailability of the product are improved.

This invention provides tranexamic acid liposomes, their preparation method, and applications, relating to the field of nanoliposome technology. This invention utilizes a simple process to prepare tranexamic acid liposomes by rationally combining the ratios of tranexamic acid, phospholipids, and cholesterol. This invention achieves high loading capacity and high loading rate for the active ingredient tranexamic acid, maintaining its stability for a long time under various temperature conditions. The tranexamic acid liposomes prepared by this invention have a particle size between 10-50 nm, enabling better penetration into the stratum corneum and targeting the basal layer of the skin, providing a long-lasting and stable effect. Compared to liposomes prepared by other processes, they exhibit excellent transdermal permeability and skin retention, which is more conducive to the efficacy of the active ingredient, significantly improving its bioavailability and resulting in a greater skin-lightening effect.

A patch composition for targeting herpes virus comprising the following ingredients: a patch base, trisodium phosphate, malic acid, sorbitol, sodium benzoate, cellulose gum, peppermint, sodium saccharin, naringin, wind wheel grass extract, xanthan gum, polyethylene glycol-8, calcium carbonate, hydroxyethyl cellulose, hydroxypropyl guar gum, sodium nitrate, hydrated silica, sodium lauryl sulfate, strontium chloride hexahydrate, tranexamic acid, two-faced needle extract, sodium monofluorophosphate, sea salt, potassium nitrate, sodium chloride, and purified water q.s.

The present invention provides a solid composition containing: crystals composed of ibuprofen and tranexamic acid; and a surfactant.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

A method for enhancing solubility of tranexamic acid comprising the following steps:a) Initially dissolving tranexamic acid in water;b) Measuring a pH value of the solution obtained in Step (a);c) Addition of a strong acid (that dissociates completely in water) to the solution obtained in Step (a) and simultaneously monitoring the decrease in the pH value of the solution until approximately pH 4.5 or less than pH 4.5 is reached, to increase solubility of tranexamic acid;d) Addition of tranexamic acid to reach the pH value of the solution obtained in Step (c) above the pH 2.0; ande) Repeating Steps (c) and (d) until a desired amount of tranexamic acid is added to the solution of Step (a), that is a desired concentration of tranexamic acid in the final solution is reached.

The invention discloses a medical sponge for laparoscopic surgery and a preparation method thereof, and relates to the field of medical sponges, a sponge matrix is composed of polyvinyl alcohol, gelatin for the matrix, collagen and sodium alginate for the matrix, and is provided with directionally arranged macroporous channels; the drug-loaded porous microspheres are composed of gelatin for microspheres and sodium alginate for microspheres and are loaded with tranexamic acid, an antibacterial agent and hemostatic active ingredients, oriented microporous channels are formed in the microspheres, and macroporous channels of the sponge matrix and microporous channels of the drug-loaded microspheres form a communicated cross-scale pore network; a hierarchical porous structure with the average diameter of a macroporous channel being 12-40 microns and the average diameter of a microporous channel being 3.0-8.0 microns is realized, the diameter of the drug-loaded microspheres is 50-90 microns, the drug-loaded microspheres are uniformly dispersed according to the proportion of 25%-35% of the dry weight of a matrix, the total drug loading capacity of active drugs reaches 1.5%-4.0% of the weight of the microspheres, and the problems that traditional medical sponge drug release is uncontrollable and the hemostatic and antibacterial effects are poor are solved. The clinical application value is wide.

The invention belongs to the technical field of medical dressings, and discloses a recombinant human collagen combined nano-silver ionic liquid-containing dressing and a preparation method thereof. The invention discloses a liquid dressing. Comprising the following raw materials: 8 to 15 parts of polyvinyl alcohol, 3 to 6 parts of calcium alginate, 1 to 3 parts of polydimethylsiloxane, 0.1 to 0.5 part of an antibacterial agent, 2 to 5 parts of bioactive protein, 1 to 4 parts of sodium hyaluronate, 2 to 5 parts of chitosan, 0.5 to 2 parts of tranexamic acid, 0.3 to 1 part of polypeptide, 0.2 to 0.8 part of an anti-inflammatory agent, 0.5 to 1.5 parts of ethylhexylglycerin, 10 to 20 parts of glycerin, 0.5 to 1.2 parts of carbomer, 0.1 to 0.3 part of biguanide hydrochloride and 40 to 60 parts of deionized water. The comprehensive improvement of the liquid dressing on the aspects of antibiosis, repair promotion, stability and safety is realized. All the components are matched to achieve the effects of broad-spectrum antibacterial property, healing time shortening and activity protection. Temperature gradient control, microwave activation and high-pressure homogenization are adopted in the process, the compatibility of all the raw materials is improved, the dressing is stable in physical performance, free of layering during storage and high in safety, and the requirements for skin wound protection and repair are met.

A liquid oral composition comprising the following component (a): at least one component selected from tranexamic acid and salts thereof, and component (b): a perfume; and satisfies at least one of the following conditions 1 and 2. (Condition 1) The composition further contains the following component (c): a surfactant having an HLB value of 13.0-20.0, wherein the mass ratio (c) / ((a) + (b)) is 3.5 or more. (Condition 2) The color difference [Delta] E * is 0.0-2.5.

The present invention belongs to the field of cosmetic technology, and specifically relates to an antioxidant whitening composition, its preparation method, and application. Every 100 parts of the antioxidant whitening composition include the following components in parts by weight: 0.1-5.0 parts of saccharide isomers, 0.2-2.5 parts of tranexamic acid, 0.5-10 parts of Chondrus crispus extract, 0.2-2.5 parts of tea extract, 1.0-4.0 parts of yeast extract, 0.2-3.0 parts of plant whitening agent, 0.2-0.8 parts of thickener, 0.2-5.0 parts of anti-allergic agent, 0.2-0.5 parts of preservative, and the balance of water. The antioxidant whitening composition of the present invention can solve the shortcomings of the existing technology in terms of single antioxidant and whitening properties, has excellent antioxidant and whitening effects, is non-irritating, and is suitable for people with different skin types.

This invention belongs to the field of biopharmaceutical technology and discloses a tranexamic acid sustained-release composition, its preparation process, and its application. By weight, the composition comprises 100-120 parts tranexamic acid, 14-18 parts sustained-release material, 5-8 parts magnesium stearate, 2-5 parts colloidal silica, and 3-5 parts polyvinyl alcohol. The sustained-release material is selected from a combination of hydroxypropyl cellulose and ethyl cellulose, or a combination of hydroxypropyl methyl cellulose and microcrystalline cellulose, or a combination of sodium carboxymethyl cellulose and hydrogenated vegetable oil. This invention utilizes the synergistic effect of the sustained-release material and the synergistic effect between the sustained-release material and polyvinyl alcohol to maintain zero-order or first-order release of the drug, achieving a steady-state blood drug concentration and prolonging the duration of action, thereby achieving a good sustained-release effect.

The invention discloses a postoperative blackening inhibiting and brightening repairing body lotion and a preparation method thereof, the postoperative blackening inhibiting and brightening repairing body lotion comprises the following components by mass: 1-3% of tranexamic acid, 2-5% of nicotinamide, 3-6% of an aloe vera extract, 0.5-2% of menthol, 0.1-0.5% of an anti-allergy agent, 5-10% of a humectant, 2-4% of an emulsifier, 0.5-1% of a thickener, 0.05-0.2% of a pH regulator, 0.3-0.8% of a preservative, and the balance of deionized water. The invention has the following beneficial effects: by adding tranexamic acid into the formula, the activity of tyrosinase and melanocyte proliferation can be inhibited, melanin generation can be reduced from the source, nicotinamide can block melanin from being transferred to cuticle, and nicotinamide and tranexamic acid generate a synergistic effect, so that the blackness inhibition effect can be enhanced; the anti-inflammatory and moisturizing functions can be provided, then the postoperative skin inflammation reaction is reduced, menthol added in the formula can generate cooling feeling when activated, postoperative pain and scorching discomfort are effectively relieved, and the anti-allergy agent can reduce the skin allergy risk and improve the product safety.

This invention discloses a multi-repair and anti-pigmentation composition and its preparation method, including the pre-preparation of a sustained-release carrier, aqueous phase preparation, pre-dissolution of active ingredients, emulsification and mixing, and cooling treatment. In use, the raw materials are pre-treated by adding deionized water, glycerin, sodium hyaluronate, and disodium EDTA to a mixing tank and stirring evenly at 300-400 r / min and 45-50℃ until completely dissolved, obtaining an aqueous matrix. A small amount of deionized water is added and stirred at 500-600 r / min and 35-40℃. Sustained-release microspheres are prepared by spray drying and set aside. The remaining active ingredients, such as nicotinamide, tranexamic acid, and repairing components (such as Centella asiatica extract), are pulverized and passed through an 80-mesh sieve to remove impurities and set aside. The aqueous matrix is ​​cooled to 30-35℃, and a thickener composed of xanthan gum and hydroxyethyl cellulose is added. The mixture is stirred at low speed (200-300 r / min) for 15-20 minutes until the system is homogeneous and free of particles.

The present invention relates to solid compositions. The present invention addresses the problem of providing a solid composition containing ibuprofen in which changes in properties are suppressed. [Solution] A solid composition comprising the following components: (A) ibuprofen; (B) at least one substance selected from the group consisting of tepiperidine and salts thereof; and (C) at least one compound selected from the group consisting of tranexamic acid and salts thereof, in which the solid composition does not include a solid composition containing levocetirizine or loratadine.

The invention discloses a soluble microneedle array transdermal drug delivery freckle-removing mask and a preparation method of the soluble microneedle array transdermal drug delivery freckle-removing mask. The mask comprises a backing layer and a soluble micro-needle array arranged on the backing layer, the micro-needle array is composed of a needle tip and a base, and the needle tip comprises a freckle-removing active component, a nano-carrier material, a micro-needle matrix material and a stabilizer. The freckle-removing active components comprise tranexamic acid, sodium ascorbyl phosphate, Maojian green tea extract, licoflavone and nicotinamide; the nano carrier material is selected from hydroxyl cyclodextrin, chitosan nanoparticles and alginic acid-chitosan nanoparticles; the microneedle matrix material comprises hyaluronic acid, polyvinylpyrrolidone and polyvinyl alcohol. Through combination of a nano-carrier technology and a micro-needle system, the drug loading capacity, stability and transdermal efficiency of freckle-removing active ingredients are remarkably improved, and the freckle-removing micro-needle has the advantages of being good in freckle-removing effect, painless, noninvasive, convenient to use and the like, and is suitable for prevention and treatment of chloasma, freckles, hyperpigmentation after inflammation and other pigmented skin diseases.

The invention provides a composition with whitening, tightening and dull yellow improving effects and a preparation method thereof, the composition comprises raw materials such as nicotinamide, tranexamic acid, glycyrrhiza glabra root extract, biological tightening peptide and the like, and auxiliary components such as grape seed extract, modified hyaluronic acid and the like can also be added. The biological tightening peptide is prepared from palmitoyl tripeptide-5, palmitoyl tetrapeptide-7 and acetyl hexapeptide-8 according to a specific ratio. The preparation method comprises the steps of water phase preparation, active component dispersion, bioactive component addition, homogeneous stabilization and the like. Experiments show that the composition can efficiently inhibit tyrosinase activity and melanin synthesis and promote generation of elastin and collagen, is high in oxidation resistance and good in transdermal absorption effect, can be used for preparing cosmetics and has a good application prospect.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The invention relates to the technical field of cosmetics, in particular to a brightening and firming mask which comprises mask base cloth and essence, and the essence is composed of functional components and the balance of matrix. Wherein the functional components comprise fine euglena polysaccharide, hydrolyzed collagen, tranexamic acid, hydroxyethyl piperazine ethanesulfonic acid, glutathione and copper peptide. According to the mask provided by the invention, firstly, the euglena gracilis polysaccharide and the hydrolyzed collagen are used for rapidly and synergistically tightening and smoothing the skin from the aspect of physical tightening, and meanwhile, the hydrolyzed collagen can stay in the deep part of the epidermal layer for a long time to promote the synthesis of the collagen so as to bring an endogenous skin tightening effect; then tranexamic acid, glutathione and copper peptide are compounded according to a specific proportion and have a synergistic effect, the activity of tyrosinase is inhibited, and then cutin is mildly stripped through hydroxyethyl piperazine ethanesulfonic acid, so that the functional components rapidly whiten and brighten the skin.

Concentrated tranexamic acid compositions suitable for intramuscular administration via auto-injector are provided. The concentrated tranexamic acid compositions enable the use of a syringe and an auto-injector to facilitate rapid, reliable, and simple self or buddy administration, under extreme duress on the battlefield, by minimally trained users. Methods of treating non-compressible hemorrhage are also provided. Kits and auto-injectors comprising the tranexamic acid compositions are further provided.

The invention belongs to the technical field of skin care products, and particularly relates to a skin care mask and a preparation method thereof. The skin care mask is prepared from the following raw materials: glycerol, low-molecular sodium hyaluronate, high-molecular sodium hyaluronate, allantoin, nicotinamide, arbutin, tranexamic acid, glucose, squalane, tocopherol, carbomer, resveratrol, panthenol, 1, 3-butanediol, triethanolamine, citric acid, an emulsifier, a preservative and deionized water. The mask product is comprehensive in effect and has the functions of moisturizing, whitening and brightening, resisting oxidation and the like; the composition is mild and stable and adapts to sensitive skin; and the cream is light in texture, good in ductility, non-sticky in thick application and good in use feeling.