The present disclosure pertains to novel
Glucagon like
Peptide-1 (GLP-1) (7-37) analogs having an
amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced
adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved
potency and duration of action and are suitable for
oral administration. The analogs of present disclosure may be useful in treatment of diabetes and
obesity.