4results about How to "Rapid hemostasis" patented technology

This invention relates to a two-component cross-linked oxidized nanocellulose spray hemostatic gel, its preparation method, and its application, belonging to the field of biomedical materials. Addressing the problems of weak adhesion, insufficient mechanical properties, and biocompatibility risks in existing hemostatic materials, this invention introduces aldehyde groups using sodium periodate to prepare an adhesive component (TOCN-CHO), and simultaneously modifies the carboxyl groups of TOCN with lysine to create a cross-linking component (TOCN-Lys). After the two components are sprayed and mixed, the aldehyde groups of TOCN-CHO bind to the amino groups on the tissue surface to achieve wound sealing. Simultaneously, the amino groups of TOCN-Lys form a Schiff base cross-linking network in situ with the aldehyde groups of TOCN-CHO, enhancing mechanical strength while eliminating aldehyde toxicity. The gel retains shear-thinning properties and can be sprayed. Animal experiments show that the hemostasis time is reduced to 28 seconds. It also exhibits biodegradability and renewability, effectively solving the problem of synergistic optimization of adhesion, mechanical strength, and biocompatibility, making it suitable for emergency hemostasis and surgical scenarios.

The application discloses a kind of high expansion cellulose sponge with arch layer structure and its preparation method and application.The method is: with carboxymethyl cellulose and cellulose or its micro-nano fiber as raw material, crosslinking agent is added to prepare hydrogel.Subsequently, the sponge sample is obtained by two-way freezing of hydrogel-freeze drying, the sponge sample is soaked in the solution that can be reacted with carboxyl, the solution includes at least one of calcium chloride solution, chitosan solution or the mixed solution of two, finally, the sponge is obtained by secondary freeze-drying.The sponge of the application has good biocompatibility, high liquid absorption rate, and the volume expansion ratio can reach 10-15 times;after compression, it is used for bleeding site, can swell rapidly, block wound, and quickly stop bleeding.The sponge of the application has arch layer structure between layers, can realize high compression, and can provide expansion support force for more than 4 hours.The sponge prepared by the application can be used for deep bleeding, such as deep and narrow penetrating wound bleeding, human interface bleeding, etc.

This utility model discloses an arterial hemostat, which includes a pressure plate, a fixing component, a hemostatic component, and a coagulation-promoting layer. The pressure plate and the fixing component form a receiving space. The hemostatic component is mounted on the pressure plate, and a coagulation-promoting layer is provided at one end of the hemostatic component facing the receiving space. By adjusting the hemostatic component, the coagulation-promoting layer is brought closer to the patient's puncture site to apply pressure and stop bleeding at the puncture site. This utility model solves the problem of long compression hemostasis time after arterial puncture by providing a coagulation-promoting layer at the adjustment part.

This invention discloses an anti-swelling asymmetric hemostatic dressing, comprising two layers: an upper layer of highly adhesive hydrogel and a lower layer of non-adhesive hydrogel. The anti-swelling asymmetric hemostatic dressing is prepared by first adding a non-adhesive solution A to a mold and photocuring it, then adding a highly adhesive solution B and photocuring it again. The dressing of this invention, with its highly adhesive hydrogel upper layer and non-adhesive hydrogel lower layer, possesses both adhesive and anti-adhesive properties. Furthermore, the hydrogel is anti-swelling, enabling rapid hemostasis within 10 seconds, easy peeling, and promotion of wound healing.