112 results about "Centella" patented technology

It relates to Centella asiatica-derived exosomes, which is useful in the treatment and / or care of skin. In particular, Centella asiatica-derived exosomes is effective in enhancing skin whitening, reducing skin wrinkles, enhancing skin hydration, and improving skin antioxidant capacity.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a blood-activating and detoxifying traditional Chinese medicine formula and a nanogel preparation method thereof. The invention provides a traditional Chinese medicine formula for promoting blood circulation and removing toxicity and a nanogel preparation method of the traditional Chinese medicine formula for promoting blood circulation and removing toxicity to solve the problem that in the prior art, a good external application traditional Chinese medicine formula capable of being used for skin with damp-heat toxin accumulation does not exist, and the traditional Chinese medicine formula for promoting blood circulation and removing toxicity and the nanogel preparation method of the traditional Chinese medicine formula for promoting blood circulation and removing toxicity comprise monarch drugs, ministerial drugs, adjuvant drugs and conductant drugs, the ministerial drugs comprise honeysuckle flowers, fructus forsythiae, paris polyphylla, cortex dictamni and fructus kochiae, the adjuvant drugs comprise radix salviae miltiorrhizae, flos carthami, garden balsam stems and centella asiatica, and the conductant drug comprises bletilla striata. The traditional Chinese medicine composition provided by the invention is precise and appropriate in compatibility and distinct in gradation, and can form a synergistic treatment chain of clearing heat, detoxifying, activating blood and promoting tissue regeneration, so that the wound healing speed of the skin surface is accelerated, and the traditional Chinese medicine composition has a relatively good curative effect on damp-heat and toxic stasis type skin diseases.

The invention belongs to the technical field of plant extraction, and particularly relates to fokienia hodginsii heartwood essential oil and an extraction process and application thereof in termite prevention and control. The extraction process of the Fujian cypress heartwood essential oil comprises the following steps: mixing Fujian cypress heartwood powder, NaCl and water, carrying out ultrasonic treatment, carrying out steam distillation extraction treatment on the obtained mixture, and collecting an upper oily substance in an extracting solution, so as to obtain the Fujian cypress heartwood essential oil, the content of NaCl in the mixture is 8 to 10 weight percent. The key point of the invention is that NaCl with a specific concentration is added when the ultrasonic-assisted steam distillation extraction process is adopted to extract the essential oil from the Fujian cypress heartwood, so that on one hand, the extraction rate of the Fujian cypress heartwood essential oil can be improved, and on the other hand, the extraction of some heavy oil components with good biological activity in the Fujian cypress heartwood is facilitated; therefore, the obtained centella asiatica heartwood essential oil shows excellent contact killing, repelling and fumigating effects on termites.

The invention discloses an oil-controlling, soothing and repairing composition and a preparation method thereof. The oil-controlling, soothing and repairing composition is prepared from a herba portulacae extract, a herba centellae extract, a baropetalum chinense leaf extract and a plankton extract. According to multiple experimental researches, the composition obtained by compounding the extracts has excellent effects of controlling oil, inhibiting activity of propionibacterium acnes, relieving and repairing, is mild and non-irritant, and has a good popularization and application prospect.

The present application relates to the technical field of wound repair, and provides a traditional Chinese medicine composition for promoting wound healing and a preparation method thereof.The traditional Chinese medicine composition comprises a first traditional Chinese medicine composition and a second traditional Chinese medicine composition which are applied to the acute phase and the repair proliferation phase.The former comprises naked flower purple perilla extract, nectarine leaf extract, purple perilla extract, dragon's blood micro powder, spironast extract, centella asiatica volatile oil, rhubarb extract, borneol, mussel mucin, medicinal glycerol and purified water.The latter comprises red algae extract, nectarine leaf extract, radix astragali extract, panax notoginseng total saponins, aloe extract, dendrobium officinale extract, sea buckthorn extract, pinctada martensii purified peptide, snail glycosaminoglycan, medicinal glycerol and purified water.The composition can play the roles of antibiosis, anti-inflammation, hemostasis, analgesia and astringency in the acute phase, and can promote angiogenesis, collagen synthesis and epithelial regeneration in the repair proliferation phase, so that the wound is rapidly repaired and healed.

The invention relates to a traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of a medicine for relieving renal fibrosis caused by ferroptosis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 to 30 parts of radix salviae miltiorrhizae, 9 to 12 parts of radix et rhizoma rhei preparata, 8 to 18 parts of peach kernel, 5 to 15 parts of radix angelicae sinensis, 9 to 15 parts of radix achyranthis bidentatae, 4 to 10 parts of radix paeoniae rubra, 9 to 20 parts of herba dendrodii officinalis, 6 to 15 parts of fructus ligustri lucidi, 5 to 10 parts of fructus corni, 9 to 15 parts of herba centellae, 3 to 6 parts of radix notoginseng powder and 10 to 30 parts of radix astragali seu hedysari. Compared with the prior art, the traditional Chinese medicine composition provided by the invention can relieve kidney fibrosis caused by ferroptosis and reduce the score of kidney injury, and compared with a model group, the expression of GSH, TFR-1, SLC7A11 and GPX4 in the traditional Chinese medicine composition group is remarkably up-regulated, and the content of 4-HNE and MDA is remarkably reduced, so that the kidney injury caused by ferroptosis is relieved, and the kidney protection effect on patients with chronic kidney diseases is achieved.

1. The name of the product under this design: Body shaping pants (Centella Asiatica Light Sculpting). 2. Purpose of this design product: for wearing. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture. 5. For parts that are difficult to see or cannot be seen during use, the top view and bottom view will be omitted. 6. The model in the design image is a background and does not belong to the design content for which protection is requested.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for improving systemic lupus erythematosus and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-30 parts of dry rehmannia, 12-26 parts of calcined turtle shell, 13-25 parts of chicken tendon ginseng, 11-18 parts of red peony root, 10-20 parts of white flower snake tongue grass, 6-18 parts of small rosmarinus officinalis, 4-15 parts of artemisia annua, 5-10 parts of centella asiatica, 4-12 parts of cimicifuga foetida, 3-10 parts of coix seed, 2-9 parts of bergamot slice, and 3-7 parts of raw licorice. Test results show that the traditional Chinese medicine composition for improving systemic lupus erythematosus prepared by the application can inhibit the expression of IL-10 and IL-17 in serum, reduce anti-dsDNA antibodies in serum, significantly improve the clinical symptoms of systemic lupus erythematosus, and has a wide application prospect.

The invention provides a natural plant feed additive for protecting livers and kidneys of livestock and poultry and a preparation method, and relates to the field of feed additives, the feed additive is prepared from centella asiatica, penthorum chinense pursh, felwort, phyllanthus urinaria, purpleflower holly fruit, isatis root, polyporus umbellatus, pericarpium arecae, uncaria, cyrtomium fortunei, talc, cortex acanthopanacis and cassia twig. Experimental data show that the feed additive can significantly inhibit the activities of ALT, AST and ALP in serum, reduce the level of TBIL, enhance the activities of SOD and GSH-Px, recover T-AOC and reduce the generation amount of MDA, so that the multi-dimensional liver protection function of laying hens with acute liver injury is realized; meanwhile, the feed additive can significantly improve the average daily gain of the fattening pigs, reduce the feed-gain ratio, reduce the activity of ALT and AST, increase the content of TP and ALB, and achieve a multi-target comprehensive physiological regulation effect; in addition, the difference between the serum BUN content and the serum Cr content of each group of fattening pigs has no statistical significance, it is proved that the fattening pigs have no risk of renal dysfunction, and a new solution is provided for developing green and efficient functional feed additives.

This invention relates to the field of external moxibustion devices in traditional Chinese medicine, and in particular to a moxa stick for clearing dampness using the thunder-fire method, and its preparation method. The moxa stick comprises moxa wool, compound Chinese herbal powder, and moxa leaf paper; the compound Chinese herbal powder includes principal, assistant, adjuvant, and guiding herbs; the principal herbs include Evodia rutaecarpa, Cinnamomum cassia, and Ligusticum chuanxiong; the assistant herbs include stir-fried Atractylodes lancea, Poria cocos, Polyporus umbellatus, Alisma plantago-aquatica, stir-fried Atractylodes macrocephala, Astragalus membranaceus, and Amomum villosum; the adjuvant herbs include stir-fried Phellodendron chinense, Sophora flavescens, Artemisia capillaris, Gardenia jasminoides, Akebia quinata, Pinellia ternata, Centella asiatica, and Rosa laevigata root; the guiding herbs include Angelica dahurica, Pogostemon cablin, Angelica sinensis, Paeonia lactiflora, Glycyrrhiza uralensis, and Nelumbo nucifera leaf. This invention, guided by compound formulation theory, material innovation, process optimization, and packaging design, provides a thunder-fire moxa stick with strong targeted dampness-clearing properties, stable combustion performance, safety, portability, and controllable quality, showing promising application prospects.

The application relates to the field of plant composite extraction, and specifically discloses a plant composite extract with soothing effect and application. The plant composite extract with soothing effect is prepared from raw materials in a weight ratio of formula: spilanthes acmella = 1: (3-5); the formula is composed of raw materials of pinus massoniana leaves and centella asiatica; and the plant composite extract with soothing effect is prepared through the following steps: S1, preparing raw materials containing pinus massoniana leaves, centella asiatica and spilanthes acmella according to the proportion; S2, crushing the raw materials in step S1, adding 15-20 times of solvent by weight for percolation extraction to obtain an extraction liquid; and S3, adding a refining agent to the extraction liquid in step S2 for decolorization and refining, and then performing centrifugal filtration to obtain the plant composite extract with soothing effect. The plant composite extract with soothing effect has the advantages that multiple plant soothing components are stably combined and play a prominent stable effect, and excellent stability is maintained during storage.

The present application belongs to the technical field of dermatosis treatment products, and particularly relates to a soft pelleted medicine and a preparation method thereof. The soft pelleted medicine is prepared from the following raw materials in parts by weight: 20-40 parts of Ramulus cinnamomi, 25-35 parts of Radix astragali, 5-15 parts of Semen persicae, 5-15 parts of Ophiopogon, 5-15 parts of Carthamus tinctorius, 15-30 parts of calcined Radix paeoniae alba, 10-20 parts of Radix angelicae sinensis, 15-30 parts of Radix rehmanniae preparata, 20-40 parts of Radix codonopsis, 5-15 parts of Radix paeoniae alba, 5-10 parts of Ephedra, 5-10 parts of Radix rubiae, 5-15 parts of Centella asiatica, 2-5 parts of Radix et Rhizoma aconiti, 5-10 parts of Salvinia natans, and 5-10 parts of Rhizoma zingiberis. The soft pelleted medicine provided by the present application has the main effects of warming yang and benefiting qi, promoting blood circulation to remove meridian obstruction, dispelling cold and dampness, removing blood stasis and promoting tissue regeneration, and is used for treating dermatosis such as scleroderma, frostbite, Raynaud's disease, skin atrophy, and the like, and particularly has remarkable effects on scleroderma, frostbite, Raynaud's disease, and skin atrophy.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to traditional Chinese medicine compound granules for treating lupus nephritis and a preparation method thereof. The formula of the traditional Chinese medicine compound granules comprises 25-35 parts of astragalus membranaceus, 8-12 parts of angelica sinensis, 8-12 parts of salvia miltiorrhiza, 25-35 parts of artemisia apiacea, 12-18 parts of caulis sinomenii, 25-35 parts of centella asiatica, 25-35 parts of raw malt and 25-35 parts of euonymus alatus. The medicinal materials are subjected to water extraction, extracting solutions are combined and concentrated into extract, maltodextrin, microcrystalline cellulose and soluble starch are selected as auxiliary materials to be dried and granulated, and the prepared traditional Chinese medicine compound granules are low in fine powder proportion, high in hardness and short in dissolution time. By adopting the dosage form of granules, not only are the characteristics of quick absorption and quick action of the decoction maintained, but also the defects of inconvenience in decoction, large dosage and easiness in mildewing during temporary use of the decoction are overcome, and the curative effect is remarkably improved.

The invention discloses a centella asiatica fermentation product and application thereof. According to the method, specific strains are adopted, and the probiotic fermentation process of centella asiatica is optimized, so that the content of bioactive substances in fermented centella asiatica is greatly increased, and the bioavailability and functional characteristics of the centella asiatica are remarkably improved. The centella asiatica fermentation product disclosed by the invention has excellent effects on inhibiting bacteria, resisting aging, relieving, moisturizing, scavenging free radicals, resisting oxidation and resisting inflammation, and is expected to be widely applied to cosmetics, daily necessities, food, health care products and medicines.

The invention relates to the technical field of raw materials of skin care products, and particularly discloses a preparation method and application of an oil-soluble composition for relieving, resisting inflammation and scavenging free radicals. The preparation method of the oil-soluble composition for relieving, resisting inflammation and scavenging free radicals comprises the following steps: step 1) mixing stephania tetrandra, oenothera biennis, hyssopus officinalis, centella asiatica and artemisia apiacea to obtain a composite plant raw material; 2) mixing the composite plant raw material with an extraction solvent, soaking, extracting, filtering, and taking filtrate; 3, the filtrate is subjected to molecular distillation to separate and extract the solvent, distillate is collected, and the soothing, anti-inflammatory and free radical scavenging oil-soluble composition is obtained.The soothing, anti-inflammatory and free radical scavenging oil-soluble composition has the advantages that the free radical scavenging effect is further improved, and a more remarkable anti-aging effect is provided for skin care products.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation and application thereof. A compatibility system of monarch, minister, assistant and guide is adopted, rhizoma atractylodis, semen coicis and cortex phellodendri are taken as monarch drugs, polygonum cuspidatum, centella asiatica and fructus kochiae are taken as minister drugs, prepared rheum officinale, radix achyranthis bidentatae and caulis spatholobi are taken as guide drugs, gynostemma pentaphyllum, radix paeoniae alba and rhizoma polygonati are taken as adjuvant drugs, the medicinal materials are compounded according to a specific mass ratio, and the mass ratio of the monarch drugs to the minister drugs to the adjuvant drugs to the guide drugs is (50-80): (50-80): (30-55): (35-70). The traditional Chinese medicine composition provided by the invention can remarkably reduce the levels of blood uric acid, serum creatinine and urea nitrogen, reduce urine protein excretion and improve inflammation, a hypercoagulation state and lipid metabolism disorder, the total effective rate reaches 90%, the adverse reaction is slight, and the recurrence rate is low.

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a composition for treating ejection fraction retention heart failure, which is technically characterized by comprising the following components in parts by weight: 8-10 parts of ginseng, 15-20 parts of salvia miltiorrhiza, 10-12 parts of radix polygonati officinalis, 10-15 parts of rhodiola rosea, 5-10 parts of pseudo-ginseng, 10-15 parts of turmeric, 15-17 parts of bighead atractylodes rhizome, 15-17 parts of poria cocos and 10-12 parts of centella asiatica. , 10-12 parts of herba lycopi and 10-12 parts of semen lepidii. Through systematic clinical observation and practice, the composition provided by the invention can obviously improve the clinical curative effect of a patient, improve traditional Chinese medicine syndromes, diastolic function indexes and exercise tolerance, and improve life quality; and the kit has a positive clinical application value for patients with clear diagnosis, accurate syndrome differentiation and good indication mastering.

The invention belongs to the field of pet food processing, and relates to a premix for improving the health of urinary tracts of pets. The premix comprises the following components in parts by weight: 25-35 parts of Chinese yams, 25-35 parts of poria cocos, 15-25 parts of dandelions, 15-25 parts of centella asiatica, 15-25 parts of semen plantaginis, 5-15 parts of rhizoma polygonati, 5-15 parts of dogwood and 5-15 parts of Chinese wolfberry fruits. By adding the premix disclosed by the invention into daily ration, the concentrations of cat blood creatinine, urea nitrogen and blood oxalic acid are reduced, the absorption and excretion of oxalic acid are influenced, and the formation of calcium oxalate calculi is prevented. The premix disclosed by the invention can relieve the kidney toxicity of sodium oxalate to cats, improve the physiological indexes of the kidneys, reduce the formation of calcium oxalate calculi and provide basic guarantee for the treatment of chronic urinary system diseases. The premix disclosed by the invention can be used for improving the urinary tract health of cats.

The application discloses a high-stability centella asiatica exosome-supramolecular co-crystal nanocomposition and a preparation method and application thereof, and aims to solve the technical problems of poor stability of centella asiatica exosome and poor water solubility of centella asiatica total glycosides. The nanocomposition comprises the following components: centella asiatica exosome, supramolecular co-crystal composite, 1,2-pentanediol, 1,2-hexanediol and water. The water solubility of the centella asiatica total glycosides is effectively improved by forming a supramolecular co-crystal composite of the centella asiatica total glycosides and hydroxypropyl-beta-cyclodextrin; the transdermal absorption of the centella asiatica total glycosides is effectively improved by compounding the supramolecular co-crystal composite with the centella asiatica exosome, the structural integrity of the centella asiatica exosome is enhanced, and the stability of both the centella asiatica exosome and the supramolecular co-crystal composite is improved. The nanocomposition has high stability and excellent antioxidant capacity, has the effects of soothing, anti-inflammation, antioxidant and anti-aging, and has a wide application prospect in the field of cosmetics.

The invention relates to a method for promoting centella asiatica seed germination, and belongs to the technical field of medicinal plant cultivation. Aiming at the technical problems of low germination rate and long period of centella asiatica seeds caused by seed coat obstacles and endogenous inhibitors, the method comprises the following steps: firstly, sequentially carrying out mechanical coat breaking, ultrasonic treatment and high-pressure permeation treatment on the seeds to break a physical barrier; mixing the seeds with a wet substrate, carrying out warm lamination at 18-25 DEG C for 25-35 days, then carrying out cold lamination at 2-6 DEG C for 50-70 days, and spraying a KNO3 solution in the cold lamination stage to activate physiological metabolism; after lamination, washing with running water, sequentially soaking with a thiourea solution, carrying out H2O2 treatment for chemical degradation, and carrying out biological adsorption by adopting an adsorbent containing bacillus subtilis and activated carbon; soaking the seeds into a mixed solution containing brassinolide, kinetin and fluridone, and carrying out gradient heating and drying; and finally carrying out germination culture. The method can significantly improve the germination efficiency and uniformity, and is suitable for centella asiatica large-scale seedling raising and medicinal resource development.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition and its tablets for treating systemic sclerosis. The traditional Chinese medicine composition of this invention consists of 15-40 parts by weight of Centella asiatica, 2-8 parts by weight of Asarum heterotropoides, 8-22 parts by weight of Cinnamomum cassia, 15-40 parts by weight of Astragalus membranaceus, and 5-16 parts by weight of Ligusticum chuanxiong. Through the rational combination of Centella asiatica, Asarum heterotropoides, Cinnamomum cassia, Astragalus membranaceus, and Ligusticum chuanxiong, it achieves the effects of clearing heat and detoxifying, warming and unblocking the meridians, promoting blood circulation and removing blood stasis, and regulating immune function. The entire formula combines cold and warm properties, and integrates tonifying and purging effects, with a mild medicinal nature, and can address the three stages of systemic sclerosis: the swelling stage, the hardening stage, and the atrophy stage of the skin.

The invention discloses a traditional Chinese medicine composition for stably maintaining disease activity of systemic lupus erythematosus as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-30 parts of radix rehmanniae, 9-15 parts of radix scrophulariae, 9-15 parts of radix paeoniae rubra, 12-15 parts of cortex moutan, 15-30 parts of artemisia apiacea, 15-30 parts of oldenlandia diffusa, 15-30 parts of hairyvein agrimony, 9-18 parts of gentiana macrophylla, 15-30 parts of rhizoma smilacis glabrae, 15-30 parts of centella asiatica and 6-15 parts of raw liquorice. The invention further provides a preparation method and application of the traditional Chinese medicine composition, the traditional Chinese medicine composition can stably maintain systemic lupus erythematosus disease activity for a long time, and is particularly suitable for mild and moderate disease activity (SLEDAI score lt; the traditional Chinese medicine composition can be used for treating systemic lupus erythematosus.

This invention provides a method for preparing a complete-element organic water-soluble fertilizer from traditional Chinese medicine extracts, belonging to the field of fertilizer technology. The raw materials for preparing the complete-element organic water-soluble fertilizer, in addition to the traditional Chinese medicine extract, include molasses fermentation products, macro-elements, micro-elements, adjuvants, and ethylenediaminetetraacetic acid (EDTA). The addition of the traditional Chinese medicine extract enables the complete-element organic water-soluble fertilizer to achieve high quality and high yield when applied, resulting in higher crop yields and stronger disease resistance, overcoming the shortcomings of existing organic water-soluble fertilizers in terms of quality and yield. The traditional Chinese medicine extract is the key raw material, and its preparation involves extracting active ingredients from powders of Erythrina variegata leaves, Atractylodes macrocephala, Cnidium monnieri, and Centella asiatica. The preparation process incorporates enzymatic hydrolysis using cellulase and pectinase. Furthermore, this invention adjusts the timing of the traditional Chinese medicine additions and the extraction temperature to enhance the high-quality and high-yield effects.

The application discloses a preparation method of a shuidi granule composition, and belongs to the technical field of traditional Chinese medicine preparations. The technical problems to be solved are to improve the preparation efficiency, the transfer rate of active ingredients and the extract rate. The technical solution is as follows: medicinal materials are extracted with water and filtered to obtain an extract; the medicinal materials include Astragalus membranaceus, salted Cuscuta chinensis, Bitter Orange Kernel, Atractylodes lancea, dried orange peel, Centella asiatica and Cicada Slough; the extract is concentrated and sieved to obtain a clear extract; a first part of malt dextrin is mixed with the clear extract, dried and sieved to obtain a dry powder; the dry powder is mixed with a flow aid, a second part of malt dextrin is added, and the mixture is uniformly mixed to obtain a shuidi granule intermediate; the shuidi granule intermediate is granulated and sieved to obtain the shuidi granule; the addition amount of the first part of malt dextrin is 3-8% of the mass of the medicinal materials; and the addition amount of the second part of malt dextrin is adjusted according to the actual yield of the dry powder, so that the first part of malt dextrin and the second part of malt dextrin account for 30-35% of the mass of the shuidi granule.

This invention provides a traditional Chinese medicine composition for treating ulcerative colitis, belonging to the field of traditional Chinese medicine pharmaceutical technology. The composition is obtained through rational formulation based on the principles of syndrome differentiation and treatment in traditional Chinese medicine, specifically composed of Forsythia suspensa, Lilium brownii, Lysimachia christinae, Sesamum indicum, Prickly ash, Pueraria lobata, Centella asiatica, Viola yedoensis, Houttuynia cordata, Portulaca oleracea, Litsea cubeba, Cirsium japonicum, Schizonepeta tenuifolia, Morus alba root, Lophatherum gracile, Lygodium japonicum, and Capsella bursa-pastoris. This invention's composition exhibits significant anti-inflammatory and de-inflammatory effects, and can repair and improve the integrity of colonic tissue structure, enhance intestinal barrier function, and achieve both symptomatic and root-cause treatment of ulcerative colitis. Simultaneously, this invention's composition has a high efficacy and cure rate in treating ulcerative colitis, and significantly alleviates symptoms such as diarrhea, bloody stools, abdominal pain, abdominal distension, anal burning, and tenesmus, greatly reducing patient suffering.

This invention relates to a highly penetrating soluble microneedle patch containing small molecule PDRN. It comprises a functional needle body and a base. The functional needle body is prepared from components comprising the following parts by weight: 4-7 parts sodium hyaluronate, 1-3 parts PDRN, 1-2 parts p-hydroxyacetophenone, 1-3 parts hydroxypropyl cellulose, 2-4 parts glutathione, 0.1-0.3 parts tranexamic acid, and 5-7 parts centella asiatica. The base is prepared from a polymer matrix material. This invention is the first to add PDRN to a soluble microneedle patch, using PDRN of different molecular weights and concentrations to prepare soluble microneedle patches with different penetration properties. This effectively solves the problems of insufficient hardness, poor penetration, and poor penetration rate of existing soluble microneedle patches, enabling it to penetrate skin with different stratum corneum thicknesses and making it applicable to various skin conditions with a wide range of applications.

This invention relates to a traditional Chinese medicine composition for treating coronary heart disease and its preparation method, comprising the following raw materials in parts by weight: ginseng 3-18 parts, astragalus 6-30 parts, centella asiatica 6-30 parts, abscissus 6-30 parts, salvia miltiorrhiza 6-30 parts, chuanxiong rhizome 5-30 parts, safflower 5-20 parts, anemarrhena rhizome 6-30 parts, salvia miltiorrhiza seed 3-12 parts, prepared licorice root 3-12 parts, and stir-fried yam 5-30 parts. This composition can significantly improve cardiac function in rats with coronary heart disease, especially enhancing myocardial contractility; simultaneously, it can regulate lipid metabolism in model mice and reduce the formation of atherosclerotic plaques. Furthermore, in both of the aforementioned models, this composition can significantly reduce the expression levels of inflammatory factors such as interleukin-1β, interleukin-6, and tumor necrosis factor-α, thereby exerting an anti-inflammatory effect. In conclusion, this composition has promising application prospects in the prevention and treatment of coronary heart disease.

The invention relates to the technical field of Chinese herbal medicine planting, and discloses a thesium chinense planting method adopting purple perilla as a host. The technical effects that the survival rate of thesium chinense is high, the yield is high and / or the production period is short are achieved by adopting purple perilla as a host.

The invention relates to the use of an extract of Phaeodactylum tricornutum alone or in combination with an extract chosen from a guarana (Paullinia cupana) extract, a ginseng (Panax ginseng) extract, a Ginkgo biloba extract, a Nelumbo nucifera extract, a Centella asiatica extract, a Piper nigrum extract, a Bacopa monnieri extract or any combination thereof and / or a compound chosen from arginine, creatine, caffeine, theanine, vitamin C, vitamin E, vitamin B, theophylline, paraxanthine, theobromine, rosmarinic acid, ellagic acid, cinnamaldehyde or any combination thereof, for maintaining and / or increasing data processing speed and / or concentration in healthy mammals. The combination of the extract of P. tricornutum and one of these extracts or one of these compounds is also described. The invention also relates to a composition comprising the combination according to the invention.

The invention relates to the technical field of separation and purification of natural products, in particular to a preparation method for separating asiaticoside and madecassoside from centella asiatica, which comprises the following steps: crushing the centella asiatica, and extracting with ethanol to obtain a crude extract; removing fat-soluble impurities by adopting an aliphatic hydrocarbon organic solvent, and extracting and enriching target glycoside by adopting a medium-polarity oxygen-containing organic solvent; determining a washing solvent by detecting physical and chemical parameters of the extract liquor, and washing the extract liquor to obtain purified extract liquor; decoloring and concentrating to obtain total asiaticoside; a crystallization performance prediction value is obtained based on quality fingerprint data of total glycosides, the data is monitored in real time in the crystallization process to dynamically adjust the process, and finally high-purity asiaticoside and madecassoside finished products are obtained through fractional crystallization. The method is simple to operate, the solvent can be recycled, and the method has remarkable economical efficiency and large-scale production feasibility.