The invention discloses a compound solid mouth wash effervescent tablet and a preparation method thereof. The effervescent tablet is prepared from honeysuckle extract, chlorhexidine acetate, mannitol, pregelatinized starch, sodium carboxymethyl starch, lactose, acesulfame, polyethylene glycol, L-cysteine, sodium bicarbonate, menthol, lauryl sodium sulfate, DL-tartaric acid and hydroxypropyl methylcellulose. The preparation method comprises the following steps: grinding and screening each raw material; uniformly mixing according to the proportion; and granulating, drying, grinding, mixing and tabletting. The effervescent tablet contains polyphenols, flavonoids, vitamins, amino acids and other multiple bio-reductive drugs, has the effects of diminishing inflammation and resisting allergy, can be used for effectively relieving development of ulcer, preventing or alleviating gingivitis to achieve the effect of strengthening teeth, can be used for killing dental bacteria, reducing injury of the dental bacteria on teeth and gum, effectively cleaning the oral cavity and reducing halitosis, and can indirectly improve the body immunity if being taken for a long time.