72results about How to "Treat infection" patented technology

The present invention provides methods of inhibiting orthopoxvirus replication and / or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof. These compounds are particularly useful as inhibitors of vaccinia virus and variola virus replication and / or for the treatment of vaccinia virus and variola virus infection. The nucleoside compounds may be administered alone or in combination with other agents active against orthopoxvirus infection, in particular against vaccinia virus or variola virus infection. Another aspect of the present invention provides for the use of such nucleoside compounds in the manufacture of a medicament for the inhibition of orthopoxvirus replication and / or for the treatment of orthopoxvirus infection. Yet a further aspect of the present invention provides such nucleoside compounds for use as a medicament for the inhibition of orthopoxvirus replication and / or for the treatment of orthopoxvirus infection.

The invention provides an application of sulfonamide compounds in preparing medicines inhibiting medicine resistant bacteria activities, and especially relates to the application of sulfonamide compounds in preparing medicines inhibiting the activities of NDM-1-producing medicine resistant bacteria. The sulfonamide compounds have a general structural formula (I), wherein A ring represents C5-C10 aryl ring or a 5-10-element heteroaryl ring; R1 is selected from hydrogen, hydroxyl, halogen, C1-C6 alkyl, and C1-C4 alkoxy or nitro; R2 is selected from C1-C6 alkyl, C3-C6 cycloalkyl, C5-C10 aryl group, or a C5-C10 aryl-C1-C4 alkyl group. The aralkyl group is not substituted, or is substituted by any one or more groups selected from the following: halogen, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkanoyl, and C1-C4 alkanoyloxy or nitro. The compounds have the effect for inhibiting NDM-1 activity.

The invention relates to an avian influenza virus (AIV) as well as a kit and a vaccine used for detecting and preventing the same, belonging to the technical field of biology, relating to a novel strain of separated AIV and disclosing H9N2 AIVs of three types, a kit for detecting H9N2 AIVs of three types, a vaccine for preventing H9N2 AIVs of three types and an antibody against H9N2 AIV. By utilizing the kit of the invention, the possibility whether the avian influenza is caused by the H9N2 AIVs of three types in the invention can be rapidly detected or removed, thereby controlling the epidemic situation of the avian influenza as soon as possible; and simultaneously, by inoculating the vaccine of the invention, infection due to the H9N2 AIVs of three gene types can be prevented. The invention also can provide biological information for an AIV monitoring system.

The invention discloses a charge modified lactoferrin and carrageenin combination medicine which comprises 0.01 part by weight of lactoferrin, 1.5 parts by weight of carrageenin, 5 parts by weight of carbomer, 50 parts by weight of glycerol and 0.1 part by weight of ethylparaben. The combination medicine is one of a gel, a suppository and a dressing. The combination medicine disclosed by the invention can be used for preventing and treating female human papilloma virus infection as well as preventing and treating female gynecological gram-negative bacterium infection.

The invention relates to a compound vaccine composition for preventing and treating human papillomavirus infection, a compound vaccine vaginal spray and uses thereof, and belongs to the field of vaccine preparations with targeted treatment indications. The product of the present invention can prevent cervical cancer and treat HPV infection; it is suitable for married women of any age; it can prevent and treat chronic cervicitis and cervical epithelial dysplasia caused by sexually transmitted HPV infection, including CIN I, II, III Degree, inhibit HPV reproduction, prevent cervical cancer.

The invention discloses a method for preparing lactobacillus fermentation type blueberry fruit juice. The method is characterized by comprising the following steps: (1) adding a compound lactobacillus fermentation agent into an MRS bouillon culture medium, activating, and sequentially adding fungus liquid into the fruit juice and culturing; (2) selecting fresh blueberries, washing, and blanching in water; (3) squeezing the blueberries into blueberry juice, grinding in a colloid mill, and finally adding cane sugar to regulate the sugar degree of the blueberry juice; (4) adding the ground blueberry juice into a hot water bath; and (5) inoculating the activated strain into the blueberry juice treated in the step (4), fermenting in an incubator, adding the fermented blueberry juice into the hot water bath, thus obtaining the lactobacillus fermentation type blueberry fruit juice. The method disclosed by the invention is simple in preparation process, good in product flavor and rich in nutrition. The lactobacillus fermentation type blueberry fruit juice drink prepared by the process is mellow and full in mouthfeel, excellent in flavor and sweet and sour in taste, can be directly drunk and has better flavor if frozen.

The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of influenza virus and other infectious diseases. Compositions containing the same, methods for producing the same, and methods for using the same are also disclosed, wherein the peptide constructs have the formula P1-x-P2, where P2 is a peptide associated with an infectious agent and P1 is a peptide that will bind to a class of immune cells, such as dendritic cells. The peptide construct can cause the maturation of immature dendritic cells to a more mature state. The peptide construct or the more mature dendritic cell can be administered to a subject to modulate or initiate an immune response against an infectious agent. Dyes, radioisotopes, or therapeutic agents conjugated with the dendritic cells can be used for localization of the immune target and / or prophylactic or therapeutic treatment of the disease.

The invention belongs to the technical field of genetic engineering and discloses shRNA capable of inhibiting replication and infection of Japanese encephalitis virus and application thereof. The shRNA takes a highly-conserved sequence in a Japanese encephalitis virus genome as a target sequence which is SEQIDNO.9, SEQIDNO.10, SEQIDNO.11 or SEQIDNO.12. The shRNA eukaryotic expression plasmid can be obtained by connecting a template of the shRNA with a linearized vector pGPU6 / GFP / Neo and respectively aims at Japanese encephalitis virus E and NS3 or NS4b gene mRNA sequence. The shRNA and the shRNA eukaryotic expression plasmid provided by the invention can be applied to a medicament for treating and / or preventing JEV (Japanese Encephalitis Virus) infection and provides a novel selectable medicament for treating and preventing the JEV infection.

The present invention relates to medicine composition of alprostadil and Chuanhuning / Yanhuning liposome and its preparation process. The nanometer liposome medicine contains the mixture of alprostadil and Chuanhuning / Yanhuning in the weight ratio of 0.1-1.0 to 50-300 in 10.1-80.2 weight portions, the mixture of soybean lecithin and yolk lecithin in the weight ratio of 4 to 1 in 88-440 weight portions, the mixture of cholesterol and beta-sitosterol n the weight ratio of 9 to 1 in 40-200, polyethylene glycol in 4000 15-40 weight portions, sodium glucuronate in 100 -280 weight portions and vitamin C in 160-800 weight portions. The medicine of the present invention may be used in antagonizing pneumonia adenovirus and influenza virus.

The invention relates to a depilatory paste and a preparation method thereof. Raw material components of the depilatory paste comprise: 63 to 70 parts by weight of water; 3-5 parts by weight of a humectant; 6-7 parts by weight of an emollient; 0.1 to 0.2 part by weight of a water-soluble thickening agent; 1 to 4 parts of oil-soluble thickener, 2 to 4 parts of emulsion stabilizer, 7 to 9 parts of emulsifier, 2 to 3.5 parts of pH regulator, 0.2 to 1 part of bisabolol, 0.1 to 0.3 part of allantoin, 0.2 to 0.5 part of skin conditioner and 4 to 6 parts of chemical depilatory, wherein the skin conditioner is a mixture of butanediol, water, a centella asiatica extract, a polygonum cuspidatum root extract, a scutellaria baicalensis root extract, a tea leaf extract, a glycyrrhiza glabra root extract, a chamomile extract and a rosemary leaf extract. The depilatory paste provided by the invention has excellent depilatory effect and use comfort, is suitable for a wide range of people, and is suitable for large-scale production and application.

The invention relates to a bacteriostatic air-refreshing composition and its preparation method and use. The bacteriostatic air-refreshing composition comprises, by volume, 70-95% of a solvent and 5-30% of plant essential oil, wherein the plant essential oil is cinnamon essential oil and the solvent is ethanol. The bacteriostatic air-refreshing composition has effects of refreshing air and inhibiting common pathogenic bacteria in air.

The invention provides application of isatin thiosemicarbazone compound with the following general formula (I) in preparing medicament for inhibiting activity of NDM-1. In the formula (I), R1 is selected from the group consisting of hydrogen and C5-C10 aralkyl; R2 is selected from the group consisting of hydrogen, C1-C4 alkyl and halogen; and R3 is selected from the group consisting of hydrogen and C1-C4 alkyl. The compound can significantly inhibit the activity of NDM-1.

The invention discloses a method for preparing charge modified lactoferrin. The method comprises the following operation steps: dissolving 3-hydroxy-phtalic anhydride in dimethyl sulfoxide to prepare a saturated HP solution; dissolving lactoferrin in a 0.1M sodium phosphate solution to prepare a protein solution of 20mg / mL; uniformly mixing the saturated HP solution and the protein solution of 20mg / mL, regulating the pH to 10, standing at 25 DEG C for 1 hour, dialyzing by adopting PBS which has the pH of 7.4, and filtering and sterilizing with a 0.45mu m membrane to obtain the charge modified lactoferrin. The charge modified lactoferrin can be combined with carrageenan to prepare a composition medicine for preventing and treating infection of human papilloma virus of females and preventing and treating gynecological gram-negative bacterial infection of females.

The invention belongs to the technical field of medicines and particularly relates to application and a preparation method of a triterpenoid saponin compound. The compound is used for preparing a drugfor treating fungal infection and has the following chemical structure as shown in the description. The invention also provides the preparation method. Soapberries are systematically separated to screen two triterpenoid saponins. The compound is clear in anti-fungus mechanism and the anti-fungus action is obviously superior to that of other soapberry total saponins, soapberry saponin A, soapberrysaponin B and Clemontanoside C. The anti-fungus action of the compound is equivalent to that of market main current drugs at present and the action on capsular candida is obviously superior to that of market main current drugs. The compound has the advantages of clear mechanism, exact curative effect and easiness in industrial production, and is particularly suitable for drug resistance of the market main current drugs at present and infection induced by capsular candida.

The invention discloses a feed additive, a pig feed with the feed additive and a preparation method of the pig feed. The feed additive comprises the following substances in parts by weight: 20-30 parts of soybean flour, 6-10 parts of a mixture of indigowoad roots and houttuynia cordata, 5-8 parts of portulaca oleracea, 2-3 parts of dandelion, 15-20 parts of spinach, 5-10 parts of carrots, 5-8 parts of crataegus cuneata, 10-15 parts of licorice roots and 5-10 parts of protease. The pig feed comprises 20-25 parts of wheat bran, 30-45 parts of corn, 15-20 parts of soybean meal and 5-10 parts of potatoes. By adopting the pig feed with the feed additive disclosed by the invention, the physique of pigs can be effectively improved, the immunity of the pigs can be improved, the growth velocity ofthe pigs can be increased, pig meat can be good in quality and green and healthy, and healthcare purse of modern people can be met.

The invention discloses a Chinese medicine composition which can cure the lung-heat and cough with asthma as well as respiratory infection of poultry, aiming at providing a Chinese medicine composition which can cure the lung-heat and cough with asthma as well as respiratory infection of the poultry with no drug residue in the bodies of the poultry. The materials, prepared into active ingredients according to the parts by weight, of the Chinese medicine composition of the invention comprise 10 to 100 portions of herba ephedrae, 10 to 80 portions of scutellaria, 10 to 100 portions of herba houttuyniae, 10 to 80 portions of common andrographis and 10 to 80 portions of radix isatidis. In the Chinese medicine composition of the invention, the herba ephedrae can relieve exterior syndrome and dissipate cold, reduce fever and relieve asthma; the scutellaria can remove heat and damp, and purging fire for removing toxin; the herba houttuyniae can clear away heat and toxic material and induce diuresis for treating strangurtia; the common andrographis can eliminate internal heat and toxic material, reduce swelling and ease pain and the radix isatidis can also clear away heat and toxic material, cool the blood and relieve sore throat. The composition of all the medicines can clear away heat and toxic material, relieve cough and asthma and be used for curing the lung-heat and cough with asthma as well as respiratory infection of the poultry and also results in fast and good curative effect, short period of treatment with no drug resistance, drug residue or toxic and side effects, thereby being beneficial for guaranteeing the human health.

The invention relates to virology and the prevention and / or treatment of viral infection and disease in animals, including birds and humans. The invention relates to the field of antiviral treatments. The invention further relates to methods of stimulating innate immunity and natural interferon production in humans or animals and in component parts of humans or animals, including cells and tissues. The invention also relates to the field of defective interfering (DI) viruses, including cloned DI viruses.

The present invention provides compounds comprising amino acid R groups, compositions comprising the same, and methods of inhibiting neuraminidase and / or treating influenza, Pseudomonas aeruginosa, or Bacteroides fragilis infection in a mammal.

The invention provides purpose of L-cysteine compound with a following general formula for restraining new delhi metallo (NDM)-1 activity in medicine. R is C1-C4 carbalkoxy or aromatic oxygen carbonyl or C1-C4 alkyl acyl. The compound has the function on restraining NDM-1 activity.

The invention discloses a Chinese herbal medicine feed additive containing pithecellobium clypearia, a preparation method and application thereof, and particularly relates to the field of feed additives. The Chinese herbal medicine feed additive comprises the following raw materials (in parts by weight): 60-100 parts of pithecellobium clypearia, 20-60 parts of fructus alpiniae oxyphyllae, 10-30 parts of hawthorn, 10-30 parts of nutmeg, 5-20 parts of herba lycopi, 1-10 parts of semen cuscutae, 5-20 parts of licorice, and 2-15 parts of lily. The feed additive provided by the invention is safe, free of toxic and side effects, free of drug residues, safe and reliable, and capable of improving animal immunity, and has multiple effects of resisting bacteria, diminishing inflammation, clearing away heat and toxic materials, removing necrotic tissue, promoting tissue regeneration, clearing away lung fire and the like, and capable of treating upper respiratory tract infection and promoting healthy growth of animals, and capable of effectively preventing and treating the symptoms such as diarrhea and ulcer of animals in the stress period.

The invention discloses a crocodile feed. The crocodile feed consists of the following components in parts by weight: 100-200 parts of internal organs, 50-100 parts of chicken and duck meat, 60-80 parts of trash fish, 30-40 parts of fruits and vegetables, 10-30 parts of garlic, 10-20 parts of radix bupleuri, 5-10 parts of radix isatidis and 4-7 parts of pseudo-ginseng. The crocodile feed is prepared through the following steps of making the garlic, the radix bupleuri, the radix isatidis and the pseudo-ginseng in proportion into powder, and stirring the powder with the internal organs, the chicken and duck meat and the trash fish so as to obtain the feed. The crocodile feed disclosed by the invention has the beneficial effects that a large quantity of internal organs are used for replacing meat, and besides, certain chicken and duck meat and the trash fish are matched with the internal organs, so that the crocodile feed has favorable mouth feel, is free from fishy smell, and also has certain putrefactive odor; traditional Chinese medicine components which can diminish inflammation and stop bleeding are also added, so that wounds of crocodiles, generated after the crocodiles fight and infection in mouths can be treated; and besides, sterilization can be performed through the garlic.

The invention relates to compound Ceftiofur Hydrochloride injecta, which effectively solves the problems of local pain and the like caused by uneven content distribution, poor stability, large viscosity. The technical scheme adopted by the invention is as follows: the injecta is prepared from the following components by weight percent: 1-15% of Ceftiofur Hydrochloride, 0.5-7.5% of Sulbactam Sodium, 48-93% of polyethylene glycol and 5-50% of absolute ethyl alcohol, wherein the total amount is 100%; firstly the polyethylene glycol and the Ceftiofur Hydrochloride are mixed, stirred and dissolved, the absolute ethyl alcohol is added and evenly stirred, and the Sulbactam Sodium is added, stirred and dissolved; and a microfiltration membrane is used to filter under the temperature of 30-45 DEG C, the filtrate is subpackged in bottles, and the bottles are gladded, sealed and packed to obtain the injecta of the invention. The invention overcomes the defects of easy delamination and inconvenient use of Ceftiofur suspension injecta in the market, and provides the injecta with stability, even content and rapid absorption; and the compound Ceftiofur Hydrochloride injecta also can effectively cure bacterial infection producing extended-spectrum beta-lactamase (ESBL).

Presently disclosed is a method of modulating Hepatitis B virus (HBV) replication, by contacting the cell with at least one agent that modulates at least one factor from a specified group consisting of SNAI2, SOX7 and other factors, the screening of said agent and use thereof in a medicament for treating HBV infection or disease or condition associated with a HBV infection in a subject. In one preferred embodiment, the agent is one peptide derived from SOX7 or SNAI2 or stapled peptides thereof. As a separate invention, a method of identifying at least one factor that modulates replication of a virus is also disclosed.

The invention relates to a Chinese and western drug for treating avian escherichia coli diseases. The invention is characterized in that the Chinese and western drug comprises the components by weight parts as follows: rhubarb is 10 to 30 parts, radix scutellariae is 5 to 15 parts, coptis roots are 1 to 5 parts, radix isatidis is 1 to 5 parts, and enrofloxacin is 0.5 to 5 parts. The invention has a preparation method as follows: (1) the components are got by weight parts as follows: the rhubarb is 10 to 30 parts, the radix scutellariae is 5 to 15 parts, the radix isatidis is 1 to 5 parts, and the radix isatidis is 1 to 5 parts; (2) purified water which is 2 to 3 times the weight of the total quantity of all components is added, and concentrated solution is obtained after diacolation, evaporation and concentration, wherein, the relative density of the concentrated solution is 1.05 to 1.2; (3) the enrofloxacin which is 0.1 to 1 time the weight of the concentrated solution is added in the concentrated solution, and the purified water which is 2 to 5 the weight of the concentrated solution is added, so that the Chinese and western drug is made. The invention has strengthening efficacy after extraction and separation, effectively treats chicken escherichia infection, and reduces the economic loss of raising households. The Chinese and western drug realizes the reasonable collocation and combination by selecting various active ingredients, the cost is low, the curative effect is good, the cure rate is high, and the safety and the reliability are realized.

Treatment of picornavirus infection by inhibiting miR-141 activity. Also disclosed herein are a method for identify miR-141 inhibitory compounds and a method for identifying a target viral infection to be treated by anti-miR-141 therapy.

The invention discloses a lactalbumin-oleic acid compound and carrageenan composite medicine, which consists of 0.01-1 part by weight of a lactalbumin-oleic acid compound, 0.5-1.5 parts by weight of carrageenan, 1-3 parts by weight of carbomer, 1-5 parts by weight of glycerol and 0.1-0.2 part by weight of ethylparaben. The composite medicine is in the form of a gel, a suppository or a dressing. The composite medicine can be used for preventing and treating female human papilloma virus infection as well as for preventing and treating female gynecological gram negative bacterium infection.