681results about How to "Avoid drug resistance" patented technology

The present invention discloses a 3-(2-pyrimidine amino) phenyl acrylic amide compound in the structure of formula (I) or a pharmaceutically acceptable salt or a stereisomer or a prodrug molecule. The 3-(2-pyrimidine amino) phenyl acrylic amide compound or the pharmaceutically acceptable salt can effectively inhibit the growth of various tumor cells, and inhibit EGFR (epidermal growth factor receptor), HER (human epidermal receptor2) family other protease, can be used in the preparation of antitumor drugs, and can overcome the drug resistance induced by gefitinib, erlotinib and the like.

The invention discloses a controlled-release multilayer drug-loaded artificial bone and a preparation method thereof. The controlled-release multilayer drug-loaded artificial bone is a multilayer structure which is coated layer by layer and is composed of artificial bone carrier materials loaded with drugs or a multilayer structure which is coated layer by layer and is formed by alternately arranging the artificial bone carrier materials loaded with the drugs and artificial bone carrier materials loaded with no drugs; the outline of the controlled-release multilayer drug-loaded artificial bone can be cylindrical, cuboid, square or irregular; and the artificial bone carrier materials loaded with the drugs at different layers comprise the same or different drugs. The controlled-release multilayer drug-loaded artificial bone is prepared by adopting a three-dimensional stereoscopic printing rapid prototyping technology, and the drugs distributed at the different layers are released from outside to inside layer by layer, thereby being capable of realizing multidrug combined action, regulating the releasing sequence and time of the drugs and selecting appropriate drugs to load so as to achieve the individualized treatment goal. The invention can be applied to carrying out local chemotherapy and filling and repairing bone coloboma after eradication focuses of various infections, concretions, tumours and the like of the orthopedics department.

A pharmaceutical composition comprising: at least one β-lactam antibiotic and at least one ion-chelating agent; wherein when said pharmaceutical composition is used as an anti-microbial drug, it optionally comprises further at least one aminoglycoside antibiotic.

The invention relates to biological complex enzyme toothpaste and a preparation method thereof. The toothpaste is prepared from the following components by weight percentage: 5-10% of sorbierite, 15-20% of hydrous silica, 10-20% of aluminum hydroxide, 10-20% of glycerin, 2-3% of sodium lauroyl sarcosine, 1-1.3% of flavor, 0.8-1.2% of cellulose gum, 0.3-0.6% of carrageenin, 0.3-0.5% of droxyethylcellulose, 0.5-1.2% of sodium phytate, 0.15-0.3% of saccharin sodium, 0.3-0.5% of strontium chloride, 0.1-0.3% of trisodium phosphate, 0.00003-0.00008% of staphylococcus lysozyme, 0.00005-0.00015% of muramidase, 0.00001-0.00004% of proteolytic enzyme, 0.00002-0.00005% of glycosidic hydrolase, 0.00002-0.00005% of peroxydase, 0.08-0.15% of borneol, 0.1-0.15% of borax, 0.08-0.1% of vermilion, 0.1-0.15% of natrii sulfas exsiccatus, 0.05-0.1% of triclosan, 0.1-0.4% of allantoin, and the balance of water. The total weight percentage of the components is 100%. The biological complex enzyme toothpaste has complete function.

The invention discloses a meat chicken feed. The formula of the feed consists of corn, enzymolysis bean pulp, corn albumen powder, dry corn distilled grain, edible oil and fat, calcium hydrogen phosphate, salt, composite vitamin, composite trace element, composite amino acid and composite enzyme preparation serving as main components. The feed is prepared by the following steps of: crushing the corn, the corn albumen powder, the dry corn distilled grain and the prepared enzymolysis bean pulp until granularity reaches 0.5 to 0.8 millimeters, mixing the components uniformly, adding the rest feed components, and mixing all the components uniformly to obtain the product. Aiming at the characteristics of incomplete digestive physiology and the like of the meat chicken, the enzymolysis bean pulp, a bacillus subtilis preparation and an enzyme preparation are added in the formula of the feed, so that the survival rate and the production performance of the chicken are improved, the digestive utilization efficiency of organic substances and mineral substances is improved at the same time, the emission of nitrogen and phosphorus in the manure is reduced, and pollution of the nitrogen and the phosphorus in the chicken manure to the soil and the water is effectively controlled.

The invention discloses a normal-temperature preparation method for ultra-micro fine Chinese pulsatilla powder. The method comprises the following steps of: firstly, cleaning traditional Chinese medicine Chinese pulsatilla decoction pieces, and drying the decoction pieces until the water content is less than or equal to 10 percent; crushing cut traditional Chinese medicine at normal temperature to obtain crude powder of which the granularity is 60 to 100 meshes; after milling the obtained crude powder in a rod mill, blowing the powder into a special bidirectional airflow sieving machine, sieving the powder with a 500-mesh sieve, blowing the obtained powder of which the particle size is less than or equal to 25 mum through airflow generated by a draught fan into a cyclone collector, and collecting the powder to obtain the finished product of the ultra-micro fine Chinese pulsatilla powder; and collecting the powder which does not pass through the 500-mesh sieve through a hopper, and conveying the powder through a pipe into the rod mill to be recovered and crushed. The method has the advantages that: the whole preparation process is performed at normal temperature without low temperature or other special additional conditions, the particle size of the prepared medicament is less than or equal to 25 mum, the cell wall-broken rate and the bioavailability are greatly improved, and the pharmacological effect is enhanced. Due to the adoption of the bidirectional airflow sieving machine, the preparation process of the ultra-micro fine Chinese pulsatilla powder is greatly simplified.

The invention discloses a polypeptide composition capable of effectively improving acne and repairing skin damage. The polypeptide composition comprises antibacterial polypeptides, polypeptides capable of inhibiting inflammatory response and / or polypeptides capable of promoting collagen and keratin regeneration and repairing acne marks. The polypeptide composition has the advantages that the growth and propagation of propionibacterium acnes and staphylococcus aureus can be inhibited, inflammatory response can be inhibited, edema and couperose skin can be prevented, corium layer collagen synthesis is increased, the regeneration and reinforcing of dermal-epidermis junction (DEJ) area structure tissue can be promoted, epidermis cell differentiation and maturation can be promoted, acne marks can be effectively repaired, and effective acne improving and skin damage repairing can be achieved.

Belonging to the technical field of disinfection, the invention discloses a skin disinfection gel to solve the disadvantages of existing disinfection technologies, especially preoperative disinfection technologies. The skin disinfection gel is composed of the following active components by mass: 1.5%-6% of chitosan, 1.5-10% of chitosan oligosaccharide, 2%-8% of baicalin, 0.5%-2% of chlorhexidine, 0.5%-1.5% of sodium alginate, 2%-5% of agarose, and 1.5%-5% of a mint extract. And the disinfection effect is good. The disinfection gel disclosed in the invention can be used for hand disinfection or skin disinfection in sanitary disinfection or preoperative disinfection, and with excellent disinfection effects and lasting function, it has very good application prospects and economic benefits.

The invention discloses a low molecular weight glycosylated chondroitin sulfate, whose weight average molecular weight is 3000-15000Da. The monosaccharide composition comprises acetyl galactosamine (D-GalNAc), glucuronic acid (D-GlcUA), fucose (L-Fuc), or its sulfuric ester (expressed in -OS03<->), wherein the mole ratio of D-GalNAc to D-GlcUA to L-Fuc to -OS03<-> is 1: (1+ / -0.3): (1+ / -0.3): (3.5+ / -0.5). The low molecular weight glycosylated chondroitin sulfate has a strong anti-HIV-1 virus activity, is a gp120 entry inhibitor, and can be used for preventing and / or treating AIDS. The invention also provides a method for preparing the low molecular weight glycosylated chondroitin sulfate and its composition preparation. Glycosylated chondroitin sulfate is depolymerized by the peroxide method to obtain a low molecular weight product, and then low molecular and / or high-molecular impurities of the product are removed by gel separation or ultrafiltration method. The low molecular weight glycosylated chondroitin sulfate and its medicinal composition can be prepared in the form of an injection, a lyophilized powder or a suppository.

The invention discloses a method for preparing a nanoparticle coating with the bone induction and antibiosis functions on the surface of a medical metal. According to the method, nanoparticles with different electric properties as used as a carrier, the nanoparticles are formed by mutual crosslinking of high-molecular polymers, and growth factors and antibiotics are respectively loaded in the process of preparing the nanoparticles with dissimilar electric properties, wherein factors and factor-friendly polyanions are sufficiently mixed to react first and are then immobilized into the nanoparticles through ionic crosslinking; and amino-containing antibiotics are grafted to a polyaldehyde anionic polymer through chemical crosslinking first and are then loaded into the nanoparticles through ionic crosslinking. The two types of nanoparticles are alternately assembled on the surface of the medical metal through electrostatic adsorption, covalent crosslinking is also formed among the particles, and the stability of the coating is enhanced. The coating prepared by using the method has the function of controlling adsorption and release of the growth factors and the antibiotics under the normal physiological environment, the activity of the growth factors are keep well and a strong bone induction function is achieved; and in addition, the antibiotics can be slowly released for a long time, and a good antibiosis effect is achieved.

The invention relates to an external composition, and a preparation and an application thereof and belongs to the field of medicines. The external composition provided by the invention is a medicine composition which contains chlorhexidine or officinal salt thereof, or benzalkonium bromide or officinal salt thereof and a recombinant human epidermal growth factor or a recombinant cattle alkali fibroblast growth factor. According to the invention, the medicine composition is also further prepared into gel, liniment, ointment or paste, and the gel further comprises chitosan or officinal salt thereof and hyaluronic acid or officinal salt thereof. When being used for treating vagina inflammation, the external composition disclosed by the invention can improve a vagina microenvironment, promote growth of granulation tissue and repair vagina micro damage; and when being used for skin wound atraumatic restorative treatment, the external composition also can speed up restoration and regeneration of a wound tissue, promote healing and reduce scar formation, so that the external composition has a wide medical application prospect.

The invention discloses an application method of an algae extract as an antibiotic substitute in a feed and mainly relates to the field of agricultural biotechnology and feed additives. The components such as omega-3 unsaturated fatty acid and the like contained in the extract of the algae or other plants have relatively strong inhibition or killing effect on the common harmful microorganisms in livestock and poultry and marine lives, and the extract can substitute antibiotics or chemically synthesized antibacterial agents which are often used in the feed. The method can reduce or cancel the use of the antibiotics in the feed, ensure the production performance of animals under the condition of using little or not using the antibiotics, and solve the problems of medicament tolerance, antibiotic dependency, antibiotic residue, secondary infection of the animals and the like. The algae extract is added in the feed, so the health condition of the animals can be improved and the growth of the animals can be promoted. The method is suitable for large-scale industrial production.

The invention discloses a physical antibacterial wet wipe and a preparation method thereof, wherein a wet wipe body is made with nonwoven having positively-charged antimicrobial film or nanoparticles, the antimicrobial film or nanoparticles are formed through by binding through chemical bonds; wet wipe liquid is made from RO purified water, a surfactant, a skin moisturizer, a moisturizing agent, a skin conditioner and other additives, ozone having a concentration of 0.1-1.0 mg / L is introduced to the wet wipe liquid, and the wet wipe liquid is finally added to the wet wipe body according to a certain weight ratio and is sealed and packaged to obtain the physical antibacterial wet wipe. The physical antibacterial wet wipe is a wet wipe with zero separated antiseptic, is soft, nonirritating and allergy-free for skin and is particularly suitable for allergic skin, tender skin and the like.

The invention belongs to the technical field of feed nutrition and particularly discloses a core material of an antibiotic-free feed. The core material includes following substances, by weight, 6-12 parts of a nutritional adjusting agent, 0-5 parts of a plant extract, 0-8 parts of a traditional Chinese medicine micro-ecologic preparation and 12-20 parts of functional composite minerals. The core material of the antibiotic-free feed can be used for replacing antibiotics so that a feed prepared by employing the core material can completely satisfy a nutritional requirement in normal growth of livestock and poultry and meanwhile is free of problems of drug residue and drug resistance which are caused by the antibiotics, thereby improving an environmental pollution degree and ensuring meat to be green and safe.

The invention relates to the technical field of medicines, in particular to a twin antibiotic compound formed by bonding each two parent nucleuses with the same structure of a beta-lactam antibiotic compound or of a derivative of the beta-lactam antibiotic compound with a dicarboxylic acid by two amido bonds, preparation method thereof and use thereof. The chemical structural general formula of the twin antibiotic compound is represented by a formula III. In the formula, R3 is a parent nucleus structure of a molecule of a penicillin compound or a derivative of the penicillin compound or a molecule of a cephalosporin compound or a derivative of the cephalosporin compound; and R may be alkyl and aryl or heteroaryl or substituted alkyl and substituted aryl or heteroaryl. In-vitro antibacterial experiments show that the beta-lactam twin antibiotic compound of the invention has remarkable antibacterial activity and is a novel antibacterial compound. The beta-lactam twin antibiotic compound of the invention can be used in the preparation of bacteriostats or bacteriacides as well as anti-infection medicaments. According to the general knowledge of pharmacy, the compound of the invention can be made into pharmaceutically acceptable salts or hydrates.

The present invention relates to a tampon structure, the tampon structure comprise at least one absorbent carbonaceous base with at least two precious metals, an absorber, a surface layer, and a rope. The copper ions and silver ions can be released by the at least two precious metals in aqueous solution to reach the health effects of the female vagina.

The invention relates to a bacterial cellulose / chitosan composite gel and preparation thereof, and application of the composite gel in body surface wound surface healing. The composite gel is composed of a chitosan solution, bacterial cellulose, an antimicrobial agent, a thickener solution and a neutralization agent. The invention also relates to application of the bacterial cellulose / chitosan composite gel in preparing body surface wound surface healing medicines. The preparation method comprises the following steps: uniformly mixing the chitosan solution, thickener solution, bacterial cellulose and antimicrobial agent, adding the neutralization agent to regulate the pH value to 6.0-9.0, and standing for deforming. The composite gel provided by the invention has favorable film-forming action, and performs the functions of isolating the wound surface and protecting the wound; and the bacterial cellulose / chitosan has the advantages of simple preparation process and easy technical control, and is convenient for industrial production.

The invention belongs to the medicine field, and particularly relates to repairing gel containing growth factors and a preparation method of the repairing gel .The repairing gel is prepared from 0.001%-0.02% of the growth factors, 0.05%-1% of alkaline polysaccharides, 0.5%-2% of a cellulose derivative water-soluble polymer, 0.05%-2% of natural plant polysaccharides, 0.01%-1% of a natural water-soluble polymer of extracellular polysaccharides, 0.1%-2% of carbomer, 12%-40% of a wetting agent, 0.05%-4% of a pH regulating agent, 0.01%-2% of hyaluronic acid, 0.6%-3% of a transdermal absorption agent, 0.1%-0.3% of a penetration enhancer and the balance deionized water .The repairing gel has the excellent antibacterial effect and the good moisture absorption performance and can significantly increase the cure rate of a wound surface, shorten the healing time of the wound surface and prevent scar formation.

The invention provides a mixture for controlling soil-borne diseases of tobaccos, and a using method of the mixture. The mixture mainly contains the following components: 5-15 parts of rhodiola root extract, 10-20 parts of marigold root extract, 15-35 parts of coptidis rhizome root extract and 50 parts of 95% alcohol. The using method of the mixture comprises the following steps: (1) before the tobaccos are sown, preparing the mixture and water into a solution according to the ratio of 1: 10, evenly spraying the solution to a seedling substrate, wherein 0.1-0.15L of solution is sprayed to every kilogram of substrate, and evenly mixing; after that, normally sowing, and transplanting into a big field after tobacco seedlings grow up to a standard; (2) when the tobaccos are transplanted into the big field, preparing the mixture and water into a solution according to the ratio of 1: (400-600), and filling the solution into seedling holes used for transplanting the tobacco seedlings, wherein each seedling hole is filled with 40-60ml of solution. The mixture has the characteristics of being wide in sterilization range, lasting in effect, non-toxic, safe and the like; after the mixture is adopted, the occurrence rate of the soil-borne diseases of the tobaccos is obviously reduced, and the quality of the tobaccos can be improved.

The invention relates to an anti-infection PMMA (polymethyl methacrylate) bone cement for composite chitosan quaternary ammonium salt. The composite bone cement is prepared by mixing HACC, PMMA and bone cement monomers, wherein the mass ratio of the HACC and the PMMA is 15-30%. The invention also provides a preparation method and applications for the composite bone cement. The invention has the advantages that the PMMA of the composite HACC can replace the current frequently-used PMMA antibiotic bead chain, can be applied to bone defect filling, infection prevention, treatment of chronic osteomyelitis and centrum reinforcement of osteoporosis, achieves the antimicrobial activity similar to the antibiotic bone cement, simultaneously avoids the generation of antibiotic resistance, can be used for patients with resistance to antibiotics, and has larger clinical application values; and appropriate reduction of elastic modulus is also beneficial to reducing the non-uniform stress distribution of a cured centrum and an adjacent centrum section, thus relieving the early degeneration of adjacent intervertebral disk and fracture of adjacent centrums.

The invention relates to a premix for Hu sheep ewes in gestation period, and the premix belongs to a feed additive, and particularly belongs to a special additive for Hu sheep feed. The premix comprises the following components in parts by weight: 1 part of multivitamin, 10 parts of VE-selenium powder, 20 parts of a mineral matter additive, 10 parts of a compound enzyme, 20 parts of probiotics, 10 parts of magnesium oxide, 20 parts of sodium bicarbonate, 10 parts of zeolite powder and 10 parts of sodium sulfate. Compared with the prior art, the premix of the invention has the advantages and effects that: based on the needs such as vitamin, mineral matter, trace elements and the like of the Hu sheep ewes in gestation and lactation periods, the formula is formed, and assisted by a filler for preparation of the granular feed which is convenient for the Hu sheep ewes to ingest; the premix of the invention satisfies the growth needs of the Hu sheep ewes in gestation period, self maintenance requirements of the Hu sheep ewes and the normal lactation requirements of the Hu sheep ewes in lactation; and also toxic and side effects caused by excess of trace elements are prevented.

The invention provides an application of sulfonamide compounds in preparing medicines inhibiting medicine resistant bacteria activities, and especially relates to the application of sulfonamide compounds in preparing medicines inhibiting the activities of NDM-1-producing medicine resistant bacteria. The sulfonamide compounds have a general structural formula (I), wherein A ring represents C5-C10 aryl ring or a 5-10-element heteroaryl ring; R1 is selected from hydrogen, hydroxyl, halogen, C1-C6 alkyl, and C1-C4 alkoxy or nitro; R2 is selected from C1-C6 alkyl, C3-C6 cycloalkyl, C5-C10 aryl group, or a C5-C10 aryl-C1-C4 alkyl group. The aralkyl group is not substituted, or is substituted by any one or more groups selected from the following: halogen, C1-C4 alkyl, halogenated C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkanoyl, and C1-C4 alkanoyloxy or nitro. The compounds have the effect for inhibiting NDM-1 activity.

The invention discloses bacillus subtilis JYM841 with antibacterial activity. The bacillus subtilis is preserved in a China center for type culture collection in January 10, 2014, and the preservation number is CCTCC NO: M 2014012. The bacillus subtilis JYM841 has a strong inhibitory effect on staphylococcus aureus and candida albicans, is high in antibacterial activity, wide in antibacterial spectrum, high in enzyme production, sensitive to bacterial antibiotic, drug-resistant to fungal antibiotic, high in heat-resisting ability and tolerant to acid and alkaline, has high antibacterial activity after treated at the temperature of 100 DEG C for 20min, and has tolerance to various enzymes such as trypsin, papain and protease K. An acid and alkali resistant pH (potential of hydrogen) value ranges from 6 to 10, and metabolite is stable, so that the bacillus subtilis can be applied to preparation of medicines for treating genital tract infection.

The invention discloses a DQA-PEG 2000-DSPE (Dequalinium Chloride-Polyethylene Glycol-Distearoyl Phosphatidyl Ethanolamine) conjugated compound and resveratrol liposome modified thereby. The structural formula of the compound is shown by a formula I. In terms of composition, the resveratrol liposome comprises resveratrol and a fat material, wherein the mass ratio of the resveratrol to the fat material is (1:20)-(1:40); and the fat material consists of egg yolk lecithin, cholesterol and the compound shown by the formula I in the molar ratio of (63-67):(18-22):(2-4.35) in sequence. Pharmacodynamic tests prove that mitochondrial targeted resveratrol liposome has an extremely strong cell toxic effect in in-vitro cell experiments of human lung adenocarcinoma A549 cells and drug-resistant A549 / cDDP cells thereof, a tumor sphere model and an in-vivo transplantation tumor model and can penetrate through the core of the tumor sphere. The anti-tumor effect of vinorelbine liposome on the drug-resistant A549 / cDDP cells can be obviously improved by combining the resveratrol liposome with the vinorelbine liposome for use (formula I).

The invention discloses a triphenylphosphine-polyethyleneglycol 1000 vitamin E succinate (TPGS 1000-TPP) conjugated compound, and a preparation method and application thereof. The structural formula of the compound is disclosed as Formula I. The preparation method of the conjugated compound comprises the following steps: (1) reacting triphenylphosphine and 6-bromocaproic acid to obtain 5-carboxyamyltriphenylphosphonium bromide disclosed as Formula IV; and (2) carrying out esterification reaction on the 5-carboxyamyltriphenylphosphonium bromide disclosed as Formula IV and polyethyleneglycol 1000 vitamin E succinate to obtain the conjugated compound disclosed as Formula I. The invention also discloses a mitochondrion targeted taxol liposome comprising the conjugated compound. The drug effect test proves that the mitochondrion targeted taxol liposome has strong cell toxicant action in the in-vitro cell experiment and in-vivo transplantation tumor model of human lung adenocarcinoma A549 cells and drug-resistant A549 / cDDP cells thereof and can enhance the antitumor effect of taxol on drug-resistant A549 / cDDP cells.

The invention discloses an isosorbide mononitrate timing controlled release preparation and a preparation method thereof. The isosorbide mononitrate timing controlled release preparation of the present invention has certain time-lag and long-acting stationary release, and comprises a semi-permeable membrane with drug release apertures, an isolating coating and a double layer label including a drug contained layer and a boosting layer. The isosorbide mononitrate timing controlled release preparation of the present invention is an osmotic pump tablet with certain time-lag and long-acting stationary release, and can provide a more lasting and stationary plasma concentration and is bioequivalent compared with a sale long-acting preparation Elantan.

The invention discloses a multifunctional compound cellulose fiber and a preparation method thereof. By adoption of an advanced microcapsule preparation technique and modification of a cellulose fiber solution preparation process, a cellulose fiber is modified through polyvinyl alcohol, herba centellae, proteins and vitamins to obtain the multifunctional compound cellulose fiber by means of a cellulose fiber wet spinning process. The multifunctional compound cellulose fiber prepared according to the method is capable of meeting people's demands on moisture absorption, bacteria resistance, skin caring and the like of fibers, and a product is excellent in physical and mechanical performance and stable functionally and has a promising development prospect.