36results about How to "Lower dose" patented technology

The invention discloses temperature-sensitive antibacterial hydrogel based on ultra-small-particle-size copper nanoparticles and a preparation method of the temperature-sensitive antibacterial hydrogel, and relates to the technical field of biomedical materials. The preparation method of the temperature-sensitive antibacterial hydrogel comprises the step of uniformly mixing the gel matrix, the stabilizer, the pH buffer solution and the ultra-small-particle-size copper nanoparticles to prepare the temperature-sensitive antibacterial hydrogel. The preparation method of the copper nanoparticles with the ultra-small particle size comprises the following steps that lactoferrin is dissolved in water, copper sulfate pentahydrate is added, an alkali solution is added to adjust the pH of the solution to be 8-14, then a reducing agent is added for a reaction, dialysis and drying treatment are conducted, and the copper nanoparticles with the ultra-small particle size are obtained. The hydrogel has good injectability, can release the copper nanoparticles under specific conditions and rapidly sterilize, in addition, the hydrogel is convenient to synthesize and simple to operate, has good biocompatibility, shows relatively low cytotoxicity to cells, and has relatively great application potential in the process of treating skin wound infection.

The invention relates to application of an Artemisia rupestris extract in preparation of medicines for preventing and treating lung diseases. According to the application of the artemisia rupestris extract in preparation of the medicine for preventing and treating the lung diseases, the artemisia rupestris extract is prepared by taking artemisia rupestris as a raw material, and the crude drug concentration is 20-110 mg / mL. The artemisia rupestris extract contains chemical components such as sesquiterpenoids, flavonoids, organic acids and phenylpropanoids. The medicine is a veterinary medicine. The lung diseases comprise allergic pneumonia, pulmonary fibrosis or diseases caused by injury of other lung tissues. The dosage form of the medicine for preventing and treating the lung diseases is a pharmaceutically acceptable dosage form. The pharmaceutically acceptable dosage form is oral liquid, powder, tablets, granules, capsules, pills, syrup, suspension or emulsion. The application defines the prevention and treatment effect of the Artemisia rupestris extract on lung diseases. During application, the artemisia rupestris extract is small in dosage and high in curative effect, and the weight of livestock and poultry can be greatly reduced due to the fact that lung tissue is damaged.

This invention belongs to the field of agricultural fungicides, and provides a fungicidal composition containing methamidophos and fluopyram and its application, wherein the mass ratio of methamidophos and fluopyram is 1:2-1:70; the fungicidal composition has excellent synergistic effects on crop diseases; it can effectively reduce the dosage of pesticides, slow down the development of pesticide resistance in diseases, reduce environmental pollution, and is safe for crops in field observations.

The application discloses application of ecurin and rifampicin in preparation of a synergistic anti-tuberculosis drug, and belongs to the technical field of anti-tuberculosis drugs. The core of the application is that ecurin and rifampicin are used in combination, the bactericidal activity of rifampicin is significantly enhanced, the minimum inhibitory concentration of rifampicin is reduced, and the development of drug resistance of Mycobacterium tuberculosis is effectively inhibited. The application further provides a pharmaceutical preparation and a medicine box containing the two active ingredients. The combined application scheme can reduce the clinical dosage of rifampicin, thereby reducing the adverse reactions such as hepatotoxicity of rifampicin, and is suitable for the treatment of sensitive and rifampicin-resistant tuberculosis, and has important clinical value and application prospect.

The invention provides ruthenium-dihydromyricetin, ruthenium-dihydromyricetin-loaded apoptosis vesicles as well as a preparation method and application of the ruthenium-dihydromyricetin-loaded apoptosis vesicles, and belongs to the technical field of preparation of antibacterial and anti-inflammatory products. The invention provides ruthenium-dihydromyricetin. The ruthenium-dihydromyricetin is prepared from the following raw materials: 50 to 80 parts of polyvinylpyrrolidone, 20 to 30 parts of ruthenium trichloride and 5 to 15 parts of dihydromyricetin. Ruthenium-dihydromyricetin with good dispersibility is obtained, the method is simple, and the product is uniform in morphology. Besides, the ruthenium-dihydromyricetin disclosed by the invention has antibacterial and anti-inflammatory effects, and has relatively low toxicity and relatively high biological safety in the antibacterial and anti-inflammatory process. According to the prepared ruthenium-dihydromyricetin-loaded apoptosis vesicles, the apoptosis vesicles can cooperate with ruthenium-dihydromyricetin to further improve the treatment effect on bacteria and inflammation, and the use dosage of nano-drugs can be reduced. The ruthenium-dihydromyricetin-loaded apoptosis vesicle disclosed by the invention has a wide application prospect in preparation of antibacterial and anti-inflammatory products.

The invention relates to the technical field of biological medicine, in particular to selenium and application of a selenium composition, a nasal composition and application of the nasal composition. The invention provides application of selenium in inhibition of nasal cavity or airway epithelium inflammatory factor expression and a nasal composition containing the selenium. The selenium element is used for regulating and controlling a signal channel, so that the expression of key inflammatory factors in epithelial cells of the nasal cavity or the airway is effectively reduced, the level of reactive oxygen species (ROS) of the epithelial cells of the nasal cavity or the airway is reduced, and the dual effects of inflammation resistance and oxidation resistance are achieved. Therefore, the nasal composition containing the selenium element can effectively block the preinflammatory syndrome driven by upstream oxidative stress by regulating and controlling dual mechanisms of inflammation and oxidative stress reaction, and nasal cavity or airway diseases such as rhinitis and allergic rhinitis are relieved and treated from the source.

The invention belongs to the field of biotechnology, relates to locust control, and particularly refers to the application of biological materials for regulating the expression of P120 catenin genes in locust control. The present invention can specifically silence the P120 catenin gene of locusts by injecting the dsRNA of the synthesized P120 catenin gene into the locust body cavity, thereby inhibiting the oviposition of locusts and causing a large number of deaths, with a mortality rate of 98.4%, thereby effectively inhibiting the growth of locust populations and achieving good results in preventing and controlling locusts. Due to the high efficiency, specificity and safety of the present invention, the present invention has broad application prospects in locust pest control, and has good economic benefits for protecting my country's agricultural production and ecological safety.

The invention discloses a bactericidal composition for preventing and treating corn stalk rot and application of the bactericidal composition. The bactericidal composition is formed by compounding hymexazol and benzovindiflupyr according to the weight ratio of (1-20): (1-25). The invention finds that the effect of the mixture of hymexazol and benzovindiflupyr for preventing and treating corn stalk rot caused by infection of pythium and fusarium is obviously higher than that of a single component, the mixture of hymexazol and benzovindiflupyr has a remarkable synergistic effect on pythium and fusarium when the ratio of hymexazol to benzovindiflupyr is (1: 1)-(1: 20) and (1: 1)-(15: 1), the composition has an excellent prevention and treatment effect on corn stalk rot caused by common infection of pythium and fusarium, and the safety to crops and the environment is improved.

The invention discloses a bactericidal composition and application thereof in prevention and treatment of maize dwarf mosaic disease, and belongs to the technical field of pesticides. The active ingredients of the bactericidal composition comprise carvacrol and chlorobromoisocyanuric acid, and the weight ratio of the carvacrol to the chlorobromoisocyanuric acid is 1: 1-1: 15. According to the invention, the effect of the mixture of carvacrol and chlorobromoisocyanuric acid for preventing and treating the maize dwarf mosaic disease is obviously higher than that of a single component, the synergistic effect of carvacrol and chlorobromoisocyanuric acid is obvious when the ratio of carvacrol to chlorobromoisocyanuric acid is 1: 1-1: 15, and the optimal ratio is 1: 5. The dosage of the pesticide can be reduced, the control effect is improved, the use cost is reduced, and the safety to crops and the environment is improved.

The present invention discloses a pesticide composition containing quinoline copper and clofoconazole and its application. The pesticide composition comprises active ingredients clofoconazole and active ingredient quinoline copper, and the mass ratio of the two is 1:50 to 50:1. The present invention can effectively prevent and treat diseases such as potato, tomato early blight, cucumber target spot and the like. The present application compounds clofoconazole and quinoline copper, and the two can produce a synergistic effect, thereby making the formed pesticide fungicide have a good fungicide effect, and has good activity against diseases such as potato, tomato early blight, cucumber target spot and the like; and the mechanisms of action of the active ingredients in the fungicide composition are different from each other, so that the sites of action are increased, the control spectrum is expanded, and the single selection pressure on the pathogen is reduced, which is conducive to delaying the speed of the generation of disease resistance, and the dosage is low and the cost is low. At the same time, the fungicide composition has low side effects and will not affect the safety and yield of crops.

The present invention belongs to the field of biotechnology, and relates to the prevention and treatment of migratory locusts, and in particular refers to the application of the migratory locust Partitioning defective 1 (Par‑1) gene and its dsRNA in the prevention and treatment of migratory locusts. By injecting the dsRNA of the synthesized Par‑1 gene into the body cavity of the female migratory locust, the Par‑1 gene of the migratory locust can be specifically silenced, resulting in the female migratory locusts not laying eggs and causing a large number of deaths, with a mortality rate of 100%, effectively inhibiting the reproduction and survival of migratory locusts, indicating that inhibiting the expression of the Par‑1 gene can achieve a good effect of preventing and treating migratory locusts. Due to the high efficiency, specificity and safety of the present invention, it has broad application prospects in the prevention and treatment of migratory locust pests, and has good economic benefits for protecting my country's agricultural production and ecological security.

The invention provides a weeding composition containing foxacarb, the active ingredients of the weeding composition comprise foxacarb and pyroxasulfone, and the mass ratio of foxacarb to pyroxasulfone is (1-10): (1-10); or the active ingredients of the weeding composition comprise the foxacarb, the pyroxasulfone and the terbuthylazine, and the mass ratio of the foxacarb to the pyroxasulfone to the terbuthylazine is 1: (2-5): (15-25). The weeding composition disclosed by the invention has a remarkable synergistic effect, can be used for remarkably improving the weeding effect of a medicament, reducing the dosage of the medicament, slowing down the generation of pesticide resistance and relieving environmental pollution, can be used for preventing and removing annual weeds of corn, and has an excellent weeding effect.

Use of ritonavir in the manufacture of a medicament for the treatment of human cytomegalovirus infection. Ritonavir is used to inhibit replication of the HCMV immediate early phase. By targeting the HCMV immediate early protein 1, it is stifled at an early stage in the initiation of the HCMV viral gene expression program. This mechanism, which acts upstream in the viral life cycle, offers new possibilities for the treatment of HCMV infection.

The invention belongs to the technical field of pesticides, and particularly relates to a biopesticide for preventing and treating mango anthracnose. The invention relates to a biopesticide. Active ingredients of the biopesticide are formed by compounding cytosinpeptidamycin and eugenol or L-carvone. According to the biopesticide disclosed by the invention, the compound combination of cytosinpeptidamycin and eugenol or L-carvone is taken as an active ingredient, and a hypha growth rate method is adopted to find that the compound combination can generate a synergistic effect in a verified compounding proportion, so that the control effect on mango anthracnose can be improved, and meanwhile, the use dosage of the pesticide can be reduced.

The present invention belongs to the technical field of sterilization, and discloses a sterilization composition and its application, wherein the active ingredients of the sterilization composition include tetrazolium pyridine and a compound of formula I: the mass ratio of the tetrazolium pyridine to the compound of formula I is 1:20 to 30:1. The composition of the present invention has a synergistic effect on a variety of plant pathogens, can significantly reduce the dosage, and is safe for crops and non-target organisms.

The present application relates to a kind of herbicide composition and its preparation method and application.The active ingredient of the herbicide composition includes acetochlor, oxaziclomefone, 2,4-D isooctyl ester;Wherein, the mass ratio of acetochlor, oxaziclomefone, 2,4-D isooctyl ester is (1-60) :(1-25) :(1-35).The herbicide composition has good control effect on annual weeds in spring soybean field and spring corn field, and each active ingredient synergistic effect can significantly reduce the use dosage, and the dispersion effect is good, the weeding effect is excellent, has no influence on the following crops, is environment-friendly, high safety and stable system.

The invention belongs to the technical field of pesticides, and particularly relates to a botanical pesticide composition and application thereof. Active components of the bactericidal composition comprise rotenone and rhodinol, and the weight ratio of rotenone to rhodinol is (1: 20)-(10: 1). The insecticide disclosed by the invention belongs to a botanical insecticide and is environment-friendly, and the active ingredients have an obvious synergistic effect, so that the dosage of the insecticide can be reduced, and the insecticide resistance of pests can be delayed.

The present application relates to the technical field of supramolecular, in particular to a collagen supramolecule, a preparation method and application thereof, the collagen supramolecule is prepared by taking collagen, a stabilizer, an alcohol solvent, glycerol, an ionic liquid and water as raw materials, the preparation method of the collagen supramolecule is simple and easy to operate, and the prepared collagen supramolecule has high stability. Meanwhile, in the collagen supramolecule, the collagen can not only be used as one of active ingredients to improve the skin condition, but also be used as a carrier of active ingredients to improve the solubility and transdermal performance of various active ingredients including the collagen itself, so as to solve the defects in the prior art.

The invention belongs to the technical field of pest control, and particularly relates to a method capable of effectively preventing and controlling psidium guajava leaf tortrix. The invention relates to an insecticidal composition. The insecticidal composition is prepared by binary compounding of an effective component I and an effective component II, the effective component I is pyridalyl, and the effective component II is guadipyr; the mass ratio of the effective component I to the effective component II is (1-100): (100-1). According to the prevention and control method, the insecticidal composition is selected for foliage spraying, meanwhile, the guava fruits are subjected to bagging treatment, and therefore the angutortria can be effectively prevented and controlled. When the effective components in the insecticidal composition are compounded, the insecticidal composition has a synergistic effect on psidium guajava leaf roller, and compared with a single effective component, the insecticidal composition can improve the prevention and control effect on the psidium guajava leaf roller, reduce the use dosage of pesticides and reduce the influence on the environment; in addition, generation and development of pesticide resistance can be delayed, the service life of the pesticide is prolonged, and comprehensive prevention and control of agricultural pests are facilitated.

The application belongs to the technical field of biology, and specifically discloses a kind of composition containing fish oil and polypeptide and its use in anti-inflammation.The core active ingredient of the anti-inflammatory composition is fish oil and anti-inflammatory polypeptide P1, P2 and P3 from deep-sea fish, and the amino acid sequences are SEQ ID NO.1:QPMPANCNSTG, SEQ ID NO.2:VQWMMNHF and SEQ ID NO.3:TETSQKE.Three polypeptides are naturally safe and have no cytotoxicity, can significantly down-regulate the NO production of inflammatory cells, and strongly inhibit the secretion of core pro-inflammatory factors.The application scientifically compounds fish oil and anti-inflammatory polypeptide from deep-sea fish, and the two produce significant synergistic anti-inflammatory effect after compounding, and the anti-inflammatory effect is much better than single fish oil or single polypeptide, which can be widely applied to the preparation of anti-inflammatory drugs, anti-inflammatory health foods, anti-inflammatory functional dietary supplements and skin anti-inflammatory repair cosmetics, and has broad industrialization popularization and clinical application prospect.

The application discloses a kind of pharmaceutical composition and its purposes in preparation for treating major depressive disorder of drug. The pharmaceutical composition includes esketamine and yohimbine. The yohimbine in the pharmaceutical composition provided by the application can effectively promote the antidepressant effect of esketamine, significantly reduce the dosage of esketamine when it plays the antidepressant effect, prolong the duration of antidepressant effect, and a certain dosage of yohimbine can promote the antidepressant effect of less dosage of esketamine.

The invention belongs to the technical field of prawn culture, and particularly relates to a method for treating vibrio diseases of litopenaeus vannamei seedlings through biological floccules. The method comprises the following steps: (1) preparing runway type biofloc; (2) preparing functional biofloc; and (3) treating vibrio diseases in opossum shrimp and larval shrimp stages. The vibrio disease at the big seedling stage is treated. The invention provides an effective method for treating vibrio diseases of prawn seedlings without using antibiotics, solves the problem of antibiotic abuse in the seedling raising process, and has important significance in promoting green and healthy development of the prawn seedling raising industry.

The invention belongs to the technical field of pesticide disinfestation, and discloses an insecticidal composition containing bifenthrin and application thereof.The active ingredients of the insecticidal composition comprise an active ingredient A and an active ingredient B. The active ingredient A is bifenthrin, the active ingredient B is pyrifluquinazon, and the mass ratio of the active ingredient A to the active ingredient B is 1: 50-48: 1. The insecticidal composition disclosed by the invention has a relatively good prevention and treatment effect on piercing-sucking mouthpart pests, and can effectively control the harm of the pests to crops.

The invention provides a weeding composition containing oxyfluorfen and picloram. The mass ratio of the oxyfluorfen to the picloram is (5: 1)-(1: 20). The composition can be prepared into an agriculturally suitable preparation for controlling weeds. The weeding composition disclosed by the invention has a remarkable synergistic effect, and can effectively reduce the use dosage of active ingredients, enlarge the weed control spectrum, inhibit the spread of alien invasive weed solidago canadensis, reduce environmental pollution and protect ecological diversity.

This invention belongs to the field of pesticide weeding technology, and discloses a weeding composition and its application. The weeding composition comprises active ingredient A and active ingredient B. Active ingredient A is isoxaflutole or isoxaflutole methyl ester, and active ingredient B is any one of pyrimethanil, pyrimifluridine, or bispyribac-sodium. The mass ratio of active ingredient A to active ingredient B is 1:6 to 12:1. The weeding composition of this invention has a significant synergistic effect on weeds in paddy fields.

The invention relates to the technical field of rhodamine derivatives, and particularly discloses a selenium-containing rhodamine derivative and application thereof. The rhodamine derivative containing selenium heavy atoms is innovatively provided, and the visible light absorption wavelength of the rhodamine derivative is close to a near-infrared region of 700 NM, so that the rhodamine derivative can penetrate through deeper tissue parts for deep treatment; meanwhile, the rhodamine derivative containing the selenium heavy atoms also shows a high triplet state conversion rate, and can efficiently generate active oxygen species under an illumination excitation condition, so that the killing effect on cancer cells and cancer tissues is enhanced. Compared with the prior art, the rhodamine derivative containing the selenium heavy atoms can realize efficient removal of cancer cells and cancer tissues by only needing nanomole-level concentration, so that the treatment efficiency is remarkably improved, and the drug use dosage is reduced; meanwhile, the preparation process of the rhodamine derivative is simple and easy to implement, high synthesis yield can be obtained, and the rhodamine derivative is more suitable for large-scale and low-cost production and application.

This invention provides a herbicidal composition containing benzoxam, wherein the active ingredients comprise active ingredient A and active ingredient B; the mass ratio of active ingredient A to active ingredient B is 1:10-10:1; active ingredient A is benzoxam, and active ingredient B is one or both of pyrimethanil and propyzoxystrobin. This herbicidal composition exhibits a significant synergistic effect, significantly improving the herbicidal efficacy of the herbicide, reducing the dosage required, slowing the development of pesticide resistance, and mitigating environmental pollution. This herbicidal composition can be used for weed control in non-cultivated land, demonstrating excellent herbicidal efficacy.

The invention belongs to the field of pesticides, and particularly relates to a herbicide composition containing pendimethalin and pyroxasulfone, the weight ratio of pendimethalin to pyroxasulfone is (1: 15)-(15: 1), the two active ingredients have a remarkable synergistic effect on various weeds, the two active ingredients are compounded to form a suspoemulsion composition, the stability is good, and the herbicide composition is suitable for industrial production.

The invention belongs to the technical field of agricultural insecticide, and discloses an insecticidal composition and application thereof.The insecticidal composition comprises an active ingredient A and an active ingredient B. The active ingredient A is a compound shown in the formula I. The structure of the compound shown in the formula I. The active ingredient B is any one of ethiprole or flufiprole. The mass ratio of the active component A to the active component B is (1: 45)-(45: 1). According to the insecticidal composition disclosed by the invention, different compounds of acting preparations are reasonably compounded, so that the insecticidal composition has an obvious synergistic effect on agricultural pests and has the advantages of being long in lasting effect, small in dosage, low in cost, capable of delaying the drug resistance of the pests and the like.

The invention relates to the technical field of medical image processing, in particular to a 3D Gaussian model generating and rendering method for low-dose PET image processing. The method comprises the steps that a low-dose brain PET image is input, and the brain PET image is composed of a set of voxel points; carrying out voxel point clustering to generate a simplified Gaussian model # imgabs0 #; based on the simplified Gaussian model, resampling the Gaussian ellipsoid model, and finally constructing a Gaussian distribution model # imgabs1 # of the brain PET image; the UNet model receives the brain PET image as input, so as to extract and segment the outer contour of the brain PET image; a 3D Gaussian distribution model # imgabs2 is reconstructed on the basis of a VQ-VAE self-encoder and a Stable Diffusion model, and a 3D Gaussian distribution model # imgabs2 is reconstructed on the basis of the VQ-VAE self-encoder; and rendering the 3D Gaussian distribution model # imgabs3 # into a 3D image by calculating attenuation characteristics during interaction of light and voxel point data. Under the condition of low-dose brain PET imaging, noise and artifacts in the image are remarkably reduced, and the image resolution is improved.