The present application relates to the technical field of supramolecular, in particular to a collagen supramolecule, a preparation method and application thereof, the collagen supramolecule is prepared by taking collagen, a stabilizer, an
alcohol solvent,
glycerol, an
ionic liquid and water as raw materials, the preparation method of the collagen supramolecule is simple and easy to operate, and the prepared collagen supramolecule has high stability. Meanwhile, in the collagen supramolecule, the collagen can not only be used as one of active ingredients to improve the
skin condition, but also be used as a carrier of active ingredients to improve the
solubility and transdermal performance of various active ingredients including the collagen itself, so as to solve the defects in the prior art.