57results about How to "Lower dose" patented technology

The invention discloses temperature-sensitive antibacterial hydrogel based on ultra-small-particle-size copper nanoparticles and a preparation method of the temperature-sensitive antibacterial hydrogel, and relates to the technical field of biomedical materials. The preparation method of the temperature-sensitive antibacterial hydrogel comprises the step of uniformly mixing the gel matrix, the stabilizer, the pH buffer solution and the ultra-small-particle-size copper nanoparticles to prepare the temperature-sensitive antibacterial hydrogel. The preparation method of the copper nanoparticles with the ultra-small particle size comprises the following steps that lactoferrin is dissolved in water, copper sulfate pentahydrate is added, an alkali solution is added to adjust the pH of the solution to be 8-14, then a reducing agent is added for a reaction, dialysis and drying treatment are conducted, and the copper nanoparticles with the ultra-small particle size are obtained. The hydrogel has good injectability, can release the copper nanoparticles under specific conditions and rapidly sterilize, in addition, the hydrogel is convenient to synthesize and simple to operate, has good biocompatibility, shows relatively low cytotoxicity to cells, and has relatively great application potential in the process of treating skin wound infection.

The invention relates to application of an Artemisia rupestris extract in preparation of medicines for preventing and treating lung diseases. According to the application of the artemisia rupestris extract in preparation of the medicine for preventing and treating the lung diseases, the artemisia rupestris extract is prepared by taking artemisia rupestris as a raw material, and the crude drug concentration is 20-110 mg / mL. The artemisia rupestris extract contains chemical components such as sesquiterpenoids, flavonoids, organic acids and phenylpropanoids. The medicine is a veterinary medicine. The lung diseases comprise allergic pneumonia, pulmonary fibrosis or diseases caused by injury of other lung tissues. The dosage form of the medicine for preventing and treating the lung diseases is a pharmaceutically acceptable dosage form. The pharmaceutically acceptable dosage form is oral liquid, powder, tablets, granules, capsules, pills, syrup, suspension or emulsion. The application defines the prevention and treatment effect of the Artemisia rupestris extract on lung diseases. During application, the artemisia rupestris extract is small in dosage and high in curative effect, and the weight of livestock and poultry can be greatly reduced due to the fact that lung tissue is damaged.

This invention belongs to the field of agricultural fungicides, and provides a fungicidal composition containing methamidophos and fluopyram and its application, wherein the mass ratio of methamidophos and fluopyram is 1:2-1:70; the fungicidal composition has excellent synergistic effects on crop diseases; it can effectively reduce the dosage of pesticides, slow down the development of pesticide resistance in diseases, reduce environmental pollution, and is safe for crops in field observations.

The present invention provides a pharmaceutical composition for preventing and treating avian white crown disease, belonging to the technical field of chicken breeding. The pharmaceutical composition of the present invention is prepared by mixing 10 to 30 parts of Morin hydrate, 5 to 20 parts of artemisinic acid, 5 to 20 parts of quinic acid, and 5 to 20 parts of ginsenoside total saponin sulfate derivatives. It can effectively improve the phenomena of a sharp drop in egg production rate, an increase in soft-shell eggs, and an increase in mortality rate of sick laying hens in cages, so that the egg production rate, egg quality, and lean meat content can be restored to normal levels; enhance the disease resistance of poultry, reduce stress reactions caused by factors such as drastic changes in temperature and microbial invasion, and improve the immunity of animal bodies; the dosage is small and the curative effect is significant. The high-dose oral liquid of the pharmaceutical composition prepared by the present application was used to feed sick chickens, and the effective rate of treatment reached 100%, and the cure rate reached 94.00%.

The application discloses application of ecurin and rifampicin in preparation of a synergistic anti-tuberculosis drug, and belongs to the technical field of anti-tuberculosis drugs. The core of the application is that ecurin and rifampicin are used in combination, the bactericidal activity of rifampicin is significantly enhanced, the minimum inhibitory concentration of rifampicin is reduced, and the development of drug resistance of Mycobacterium tuberculosis is effectively inhibited. The application further provides a pharmaceutical preparation and a medicine box containing the two active ingredients. The combined application scheme can reduce the clinical dosage of rifampicin, thereby reducing the adverse reactions such as hepatotoxicity of rifampicin, and is suitable for the treatment of sensitive and rifampicin-resistant tuberculosis, and has important clinical value and application prospect.

The utility model provides an ultrasonic thrombolysis catheter. The ultrasonic thrombolysis catheter comprises an infusion basket, a driving mechanism and an ultrasonic assembly. The infusion basket comprises a plurality of infusion catheters, and a hollow structure is defined by the infusion catheters. The driving mechanism is used for controlling the infusion basket to expand and open or close in the radial direction. The ultrasonic assembly comprises a plurality of ultrasonic electrodes, and the ultrasonic electrodes are fixed in the hollow structure of the infusion basket. During use, the infusion basket which is initially in a closed state is conveyed to a lesion position, and the infusion basket is expanded and opened through the driving mechanism, so that blood flows through thrombus. Thrombolysis medicine enters each infusion catheter and is conveyed to diseased tissue through the infusion holes in the infusion catheters, the thrombolysis medicine is accurately released to thrombus, accurate thrombolysis is achieved, and the dosage of the thrombolysis medicine is reduced. Meanwhile, the ultrasonic electrode is communicated with an ultrasonic generator, so that the ultrasonic generator generates ultrasonic waves, and the ultrasonic waves accelerate point dissolution by unfastening and diluting a fibrin chain, so that more drug receptor sites are exposed.

The invention provides ruthenium-dihydromyricetin, ruthenium-dihydromyricetin-loaded apoptosis vesicles as well as a preparation method and application of the ruthenium-dihydromyricetin-loaded apoptosis vesicles, and belongs to the technical field of preparation of antibacterial and anti-inflammatory products. The invention provides ruthenium-dihydromyricetin. The ruthenium-dihydromyricetin is prepared from the following raw materials: 50 to 80 parts of polyvinylpyrrolidone, 20 to 30 parts of ruthenium trichloride and 5 to 15 parts of dihydromyricetin. Ruthenium-dihydromyricetin with good dispersibility is obtained, the method is simple, and the product is uniform in morphology. Besides, the ruthenium-dihydromyricetin disclosed by the invention has antibacterial and anti-inflammatory effects, and has relatively low toxicity and relatively high biological safety in the antibacterial and anti-inflammatory process. According to the prepared ruthenium-dihydromyricetin-loaded apoptosis vesicles, the apoptosis vesicles can cooperate with ruthenium-dihydromyricetin to further improve the treatment effect on bacteria and inflammation, and the use dosage of nano-drugs can be reduced. The ruthenium-dihydromyricetin-loaded apoptosis vesicle disclosed by the invention has a wide application prospect in preparation of antibacterial and anti-inflammatory products.

The invention belongs to the field of herbicides, and particularly relates to a ternary herbicide and application thereof. The herbicide is prepared from anilofos, clomazone, butachlor, an emulsifier, a stabilizer and water. The composition provided by the invention can effectively reduce the use dosage of active ingredients, reduce the probability of phytotoxicity, prolong the lasting period, slow down the generation of drug resistance of weeds and relieve environmental pollution.

The invention relates to the technical field of biological medicine, in particular to selenium and application of a selenium composition, a nasal composition and application of the nasal composition. The invention provides application of selenium in inhibition of nasal cavity or airway epithelium inflammatory factor expression and a nasal composition containing the selenium. The selenium element is used for regulating and controlling a signal channel, so that the expression of key inflammatory factors in epithelial cells of the nasal cavity or the airway is effectively reduced, the level of reactive oxygen species (ROS) of the epithelial cells of the nasal cavity or the airway is reduced, and the dual effects of inflammation resistance and oxidation resistance are achieved. Therefore, the nasal composition containing the selenium element can effectively block the preinflammatory syndrome driven by upstream oxidative stress by regulating and controlling dual mechanisms of inflammation and oxidative stress reaction, and nasal cavity or airway diseases such as rhinitis and allergic rhinitis are relieved and treated from the source.

The invention belongs to the field of biotechnology, relates to locust control, and particularly refers to the application of biological materials for regulating the expression of P120 catenin genes in locust control. The present invention can specifically silence the P120 catenin gene of locusts by injecting the dsRNA of the synthesized P120 catenin gene into the locust body cavity, thereby inhibiting the oviposition of locusts and causing a large number of deaths, with a mortality rate of 98.4%, thereby effectively inhibiting the growth of locust populations and achieving good results in preventing and controlling locusts. Due to the high efficiency, specificity and safety of the present invention, the present invention has broad application prospects in locust pest control, and has good economic benefits for protecting my country's agricultural production and ecological safety.

The invention belongs to the technical field of insecticides, and particularly relates to a compound synergistic active insecticide. The invention relates to a compound synergistic active insecticidal composition. The active component of the compound synergistic active insecticidal composition is prepared by compounding an active component a and an active component b according to a mass ratio of (1-100): (200-1), the active ingredient a is diethyl aminoethyl hexanoate; and the active ingredient b is guadipyr or spinetoram. The diethylaminoethyl hexanoate and the guadipyr or the spinetoram are compounded, the killing effect of the diethylaminoethyl hexanoate and the guadipyr or the spinetoram is superior to that of single diethylaminoethyl hexanoate, guadipyr or spinetoram, and it is indicated that the insecticidal composition has high activity, and the prevention and removal effect on crop pests can be improved. On the basis, the dosage of the pesticide in unit area can be reduced, so that the problems of environmental pollution, pesticide residues and the like are relieved, and the method has important significance for developing green and efficient novel pesticides.

The invention discloses a bactericidal composition for preventing and treating corn stalk rot and application of the bactericidal composition. The bactericidal composition is formed by compounding hymexazol and benzovindiflupyr according to the weight ratio of (1-20): (1-25). The invention finds that the effect of the mixture of hymexazol and benzovindiflupyr for preventing and treating corn stalk rot caused by infection of pythium and fusarium is obviously higher than that of a single component, the mixture of hymexazol and benzovindiflupyr has a remarkable synergistic effect on pythium and fusarium when the ratio of hymexazol to benzovindiflupyr is (1: 1)-(1: 20) and (1: 1)-(15: 1), the composition has an excellent prevention and treatment effect on corn stalk rot caused by common infection of pythium and fusarium, and the safety to crops and the environment is improved.

The invention belongs to the technical field of pharmaceutical preparations, and provides a weeding composition containing isoxaflutole, pyroxasulfone and terbuthylazine as well as a herbicide and application thereof. The weeding composition is prepared from isoxaflutole, pyroxasulfone and terbuthylazine according to the mass ratio of (1-10): (1-20): (1-50), has a remarkable synergistic effect, and can effectively reduce the use dosage of pesticide, reduce the pesticide use frequency, reduce the pesticide use cost and reduce the adverse effect of the pesticide on the ecological environment. The weeding composition provided by the invention can expand the weeding spectrum, solves various weed problems through one-time medication, and makes up for the defects and limitations during use of a single agent; the service life of the herbicide is prolonged, and the herbicide has important significance on comprehensive treatment of weed resistance; the weeding composition is rapid in pesticide effect, long in lasting period and low in use cost, and can be used for controlling annual weeds in corn fields; the weeding composition is safe to crops.

The invention discloses a bactericidal composition and application thereof in prevention and treatment of maize dwarf mosaic disease, and belongs to the technical field of pesticides. The active ingredients of the bactericidal composition comprise carvacrol and chlorobromoisocyanuric acid, and the weight ratio of the carvacrol to the chlorobromoisocyanuric acid is 1: 1-1: 15. According to the invention, the effect of the mixture of carvacrol and chlorobromoisocyanuric acid for preventing and treating the maize dwarf mosaic disease is obviously higher than that of a single component, the synergistic effect of carvacrol and chlorobromoisocyanuric acid is obvious when the ratio of carvacrol to chlorobromoisocyanuric acid is 1: 1-1: 15, and the optimal ratio is 1: 5. The dosage of the pesticide can be reduced, the control effect is improved, the use cost is reduced, and the safety to crops and the environment is improved.

The present invention discloses a pesticide composition containing quinoline copper and clofoconazole and its application. The pesticide composition comprises active ingredients clofoconazole and active ingredient quinoline copper, and the mass ratio of the two is 1:50 to 50:1. The present invention can effectively prevent and treat diseases such as potato, tomato early blight, cucumber target spot and the like. The present application compounds clofoconazole and quinoline copper, and the two can produce a synergistic effect, thereby making the formed pesticide fungicide have a good fungicide effect, and has good activity against diseases such as potato, tomato early blight, cucumber target spot and the like; and the mechanisms of action of the active ingredients in the fungicide composition are different from each other, so that the sites of action are increased, the control spectrum is expanded, and the single selection pressure on the pathogen is reduced, which is conducive to delaying the speed of the generation of disease resistance, and the dosage is low and the cost is low. At the same time, the fungicide composition has low side effects and will not affect the safety and yield of crops.

The present invention belongs to the field of biotechnology, and relates to the prevention and treatment of migratory locusts, and in particular refers to the application of the migratory locust Partitioning defective 1 (Par‑1) gene and its dsRNA in the prevention and treatment of migratory locusts. By injecting the dsRNA of the synthesized Par‑1 gene into the body cavity of the female migratory locust, the Par‑1 gene of the migratory locust can be specifically silenced, resulting in the female migratory locusts not laying eggs and causing a large number of deaths, with a mortality rate of 100%, effectively inhibiting the reproduction and survival of migratory locusts, indicating that inhibiting the expression of the Par‑1 gene can achieve a good effect of preventing and treating migratory locusts. Due to the high efficiency, specificity and safety of the present invention, it has broad application prospects in the prevention and treatment of migratory locust pests, and has good economic benefits for protecting my country's agricultural production and ecological security.

The invention provides a bimetallic nano assembly and a preparation method and application thereof. The method comprises the following steps: A) mixing a phenolic polymer with a surfactant solution; b) mixing the solution obtained in the step A) with a hafnium chloride solution; c) mixing the solution obtained in the step B), a cross-linking agent and a copper sulfate solution; and D) adjusting the pH value of the solution obtained in the step C) to 7-9, and carrying out centrifugal precipitation to obtain the Hf-Cu polyphenol nano assembly. The coordination-mediated bimetallic HfCu-polyphenol self-assembly method provided by the invention is simple and easy to implement, green and environment-friendly, low in price and good in biocompatibility, provides a synthesis strategy of a nuclide labeled HfCu-bimetallic nano-assembly structure capable of improving tumor hypoxia, and also provides a new thought for clinical internal and external radiotherapy type tumor diagnosis and treatment.

The invention provides a weeding composition containing foxacarb, the active ingredients of the weeding composition comprise foxacarb and pyroxasulfone, and the mass ratio of foxacarb to pyroxasulfone is (1-10): (1-10); or the active ingredients of the weeding composition comprise the foxacarb, the pyroxasulfone and the terbuthylazine, and the mass ratio of the foxacarb to the pyroxasulfone to the terbuthylazine is 1: (2-5): (15-25). The weeding composition disclosed by the invention has a remarkable synergistic effect, can be used for remarkably improving the weeding effect of a medicament, reducing the dosage of the medicament, slowing down the generation of pesticide resistance and relieving environmental pollution, can be used for preventing and removing annual weeds of corn, and has an excellent weeding effect.

Use of ritonavir in the manufacture of a medicament for the treatment of human cytomegalovirus infection. Ritonavir is used to inhibit replication of the HCMV immediate early phase. By targeting the HCMV immediate early protein 1, it is stifled at an early stage in the initiation of the HCMV viral gene expression program. This mechanism, which acts upstream in the viral life cycle, offers new possibilities for the treatment of HCMV infection.

The invention belongs to the technical field of pesticides, and particularly relates to a biopesticide for preventing and treating mango anthracnose. The invention relates to a biopesticide. Active ingredients of the biopesticide are formed by compounding cytosinpeptidamycin and eugenol or L-carvone. According to the biopesticide disclosed by the invention, the compound combination of cytosinpeptidamycin and eugenol or L-carvone is taken as an active ingredient, and a hypha growth rate method is adopted to find that the compound combination can generate a synergistic effect in a verified compounding proportion, so that the control effect on mango anthracnose can be improved, and meanwhile, the use dosage of the pesticide can be reduced.

The invention discloses a bactericide composition containing picoxystrobin and application of the bactericide composition, and belongs to the technical field of pesticides. The active ingredients of the bactericide composition comprise picoxystrobin and mancozeb, and the weight ratio of picoxystrobin to mancozeb is (1: 80)-(1: 1). The invention finds that the effect of the mixture of picoxystrobin and mancozeb for preventing and treating the southern rust disease of corn is obviously higher than that of a single component, the synergistic effect of the mixture of picoxystrobin and mancozeb in the range of 1: 80 to 1: 1 is obvious, the optimal ratio is 1: 40, the composition has excellent prevention and treatment effect on the southern rust disease of corn, and the safety to crops and environment is improved.

The invention discloses a water-saving circulating system based on beam dyeing, which belongs to the technical field of textile dyeing and comprises a dye vat, a beam, a water inlet pipe, a water outlet pipe, a color fixing mechanism, a cloth inlet mechanism, a cloth outlet mechanism, a sampling cup, a reversing valve and a preparation vat. The preparation vat is added in the dyeing process, the flowing direction of water between the dye vat and the reversing valve is switched through parts such as the communicating pipe, water is stored, the collected water is switched to proper dyeing process steps for reasonable application, and the use dosage of the water, dye and auxiliaries is further reduced; the dyeing process is improved by means of the preparation vat, part of dyeing water can be consumed every time the preparation vat pumps and recycles most reuse water from the dye vat to the preparation vat stores the most reuse water, but compared with a traditional four-water process, most water can be recycled, and the difficulty of follow-up wastewater treatment is reduced.

The present invention belongs to the technical field of sterilization, and discloses a sterilization composition and its application, wherein the active ingredients of the sterilization composition include tetrazolium pyridine and a compound of formula I: the mass ratio of the tetrazolium pyridine to the compound of formula I is 1:20 to 30:1. The composition of the present invention has a synergistic effect on a variety of plant pathogens, can significantly reduce the dosage, and is safe for crops and non-target organisms.

The present application relates to a kind of herbicide composition and its preparation method and application.The active ingredient of the herbicide composition includes acetochlor, oxaziclomefone, 2,4-D isooctyl ester;Wherein, the mass ratio of acetochlor, oxaziclomefone, 2,4-D isooctyl ester is (1-60) :(1-25) :(1-35).The herbicide composition has good control effect on annual weeds in spring soybean field and spring corn field, and each active ingredient synergistic effect can significantly reduce the use dosage, and the dispersion effect is good, the weeding effect is excellent, has no influence on the following crops, is environment-friendly, high safety and stable system.

The invention belongs to the technical field of pesticide sterilization, and discloses a bactericidal composition and application thereof, the bactericidal composition comprises an active component A and an active component B, the active component A is any one of tetrazopyramid, ethaboxam or amisulbrom, the active component B is fluoxapiprolin, and the mass ratio of the active component A to the active component B is 1: 40-45: 1. The bactericidal composition can effectively prevent and treat plant oomycetes diseases, can slow down generation and development of drug resistance of pathogenic bacteria while preventing and treating the diseases, and is remarkable in bactericidal effect and good in safety to crops.

The invention relates to a two-dimensional titanium hydroxide nanosheet as well as a preparation method and application thereof. The two-dimensional titanium hydroxide nanosheet is prepared by combining an alkali-assisted hydrolysis method with an ultrasonic-assisted liquid phase crushing method. The transverse size of the two-dimensional titanium hydroxide nanosheet is 10-200nm, and the thickness of the two-dimensional titanium hydroxide nanosheet is less than 10nm. The two-dimensional titanium hydroxide nanosheet prepared by the invention has better catalytic oxidation resistance, biocompatibility and stability, and can be widely applied to the fields of catalysis and biomedicine.

The invention belongs to the technical field of pesticides, and particularly relates to a botanical pesticide composition and application thereof. Active components of the bactericidal composition comprise rotenone and rhodinol, and the weight ratio of rotenone to rhodinol is (1: 20)-(10: 1). The insecticide disclosed by the invention belongs to a botanical insecticide and is environment-friendly, and the active ingredients have an obvious synergistic effect, so that the dosage of the insecticide can be reduced, and the insecticide resistance of pests can be delayed.

The present application relates to the technical field of supramolecular, in particular to a collagen supramolecule, a preparation method and application thereof, the collagen supramolecule is prepared by taking collagen, a stabilizer, an alcohol solvent, glycerol, an ionic liquid and water as raw materials, the preparation method of the collagen supramolecule is simple and easy to operate, and the prepared collagen supramolecule has high stability. Meanwhile, in the collagen supramolecule, the collagen can not only be used as one of active ingredients to improve the skin condition, but also be used as a carrier of active ingredients to improve the solubility and transdermal performance of various active ingredients including the collagen itself, so as to solve the defects in the prior art.

The invention belongs to the technical field of pest control, and particularly relates to a method capable of effectively preventing and controlling psidium guajava leaf tortrix. The invention relates to an insecticidal composition. The insecticidal composition is prepared by binary compounding of an effective component I and an effective component II, the effective component I is pyridalyl, and the effective component II is guadipyr; the mass ratio of the effective component I to the effective component II is (1-100): (100-1). According to the prevention and control method, the insecticidal composition is selected for foliage spraying, meanwhile, the guava fruits are subjected to bagging treatment, and therefore the angutortria can be effectively prevented and controlled. When the effective components in the insecticidal composition are compounded, the insecticidal composition has a synergistic effect on psidium guajava leaf roller, and compared with a single effective component, the insecticidal composition can improve the prevention and control effect on the psidium guajava leaf roller, reduce the use dosage of pesticides and reduce the influence on the environment; in addition, generation and development of pesticide resistance can be delayed, the service life of the pesticide is prolonged, and comprehensive prevention and control of agricultural pests are facilitated.

The present invention relates to the field of plant protection technology, and more particularly to a medicament for preventing and treating citrus fruit flies based on Beauveria bassiana and a test method thereof. The medicament is prepared by mixing Beauveria bassiana with an added drug, and the Beauveria bassiana is a Beauveria bassiana Bb‑swu10 strain, and the Beauveria bassiana Bb‑swu10 strain is deposited in the General Microbiological Center of the China Microbiological Culture Collection Committee on May 15, 2024, with a deposit number of CGMCC No.41228, and the added drug is at least one of avermectin and highly effective cypermethrin. A medicament for preventing and treating citrus fruit flies based on Beauveria bassiana provided by the present invention and a test method thereof, which shows a synergistic effect by compounding Beauveria bassiana with avermectin or highly effective cypermethrin, greatly improves the control effect, and can significantly reduce the dosage of chemical pesticides, reduce environmental pollution, and effectively solve the problems that pesticides are prone to resistance and the efficacy is not obvious, and has good application prospects and promotion value.