95results about How to "Lower dose" patented technology

The invention, relating to the field of pesticide preparations, discloses a composite miticide for farmland and fruit trees. The active components of the miticide comprise 1-99 wt% of etoxazole and 1-99 wt% of one component selected from avermectin, azocylotin, propargite, clofentezine or pyridaben, wherein an acaricidal composition comprises the active components, and the acaricidal composition accounts for 1-99 wt% of the miticide. The acaricidal composition has obvious synergistic effect, increases the control effect, reduces the dosage of the active components, delays the generation of pest resistance, and reduces the environmental pollution. The miticide disclosed herein can effectively control farmland and fruit tree mites.

The invention belongs to the field of medicinal preparation, and relates to taxane medicines albumin nanoparticle preparation for injection and a preparation method of the preparation. According to the invention, the albumin nanoparticle preparation is prepared by combining the albumin with the taxane medicines to form the albumin nanoparticles by dispersing and stabilizing with the phospholipid. According to the invention, the strengthened osmosis and retention effect on the tumors by the nanoparticles are utilized, and more medicines are passively targeted and concentrated on the tumor tissues so as to improve the antitumor effect; simultaneously, due to the fact that the bioavailability in the injection way is high and the soluble albumin nanoparticle preparation for injection exists passive targeting, the administration dose can be greatly reduced, so that the medicinal concentration on the non-target parts can be effectively reduced, the toxic and side effects of the medicines can be reduced, and the good clinical application prospect can be implemented. The preparation is convenient in preparation method and is suitable for industrial mass production.

The invention discloses a pesticide compound containing thifluzamide and hexaconazole, and the application thereof; the compound comprises commonly used additive, thifluzamide and hexaconazole; and the weight part ratio of the thifluzamide to the hexaconazole is 24:1 to 1:1, and the weight percentage of the total weight of the thifluzamide and the hexaconazole is 5 to 80 percent. The invention isapplicable in preventing plant diseases in agriculture, particularly applicable in preventing rice sheath blight. The prevention effect of the invention has significant synergic effect than the single dose, and the invention reduces the used dose of the pesticide, reduces the medication cost, prolongs the service life of the preparation and reduces the adverse impact of the pesticide on the ecological environment.

The invention relates to a weeding composition for a rice direct-seeding field. The weeding composition comprises active components such as pretilachlor, pyrazosulfuron-ethyl and clomazone. The weeding composition for the rice direct-seeding field has the advantages that after the pretilachlor, the pyrazosulfuron-ethyl and the clomazone are compounded, the weeding effect can be improved, the weed-controlling spectrum is broadened, the toxicity and the residue rate are low, and the usage amount, the usage time and the service cost are obviously reduced, the effect is obviously higher than that of a single weeding agent. The weeding composition is a novel composition agent for the prevention and treatment of annual weeds in rice direct-seeding fields.

The invention discloses a pesticide composition containing butane fipronil and an organic phosphorus insecticide. The pesticide composition comprises a common adjuvant, the butane fipronil and the organic phosphorus insecticide, wherein the weight part ratio of the butane fipronil to the organic phosphorus insecticide in the pesticide composition is (1:40)-(10:1); and the weight percent of the weight sum of the butane fipronil and the organic phosphorus insecticide relative to the weight of the pesticide composition is 2-80%. The pesticide composition containing the butane fipronil and the organic phosphorus insecticide, disclosed by the invention, is used for treating Lepidoptera type pests of crops and has better fast-acting property and persistent effect compared with a single agent, and the dosage and the cost of the pesticide are reduced; and the pesticide composition containing the butane fipronil and the organic phosphorus insecticide is beneficial to environment protection and comprehensive treatment of agricultural pests.

The invention relates to an application of existing antimalarial artesunate and ulinastatin in combined treatment of pancreatitis. The combination of artesunate and ulinastatin generates a synergistic effect, enhances the therapeutic effect of ulinastatin, and reduces dosage of ulinastatin. The invention provides a new treatment use of antimalarial artesunate.

The invention relates to a corn field weeding composition which is composed of effective components A, B and C and proper amounts of pesticide adjuvants, wherein the effective component A is halosulfuron-methyl, B is nicosulfuron or rimsulfuron, and C is fluroxypyr or an ester compound thereof. The weeding composition is reasonable in components, has synergistic effect, overcomes the defects of incomplete weeding spectrum or lower activity for some weed and slow effect taking due to use of single weedicide, and lowers the risk in resistance due to use of single or two-element compounds. The weeding composition has obviously better preventing and treating effects than a single agent, lowers the consumption of the pesticide, and reduces the adverse effect of the pesticide on the ecological environment; and the weeding composition has important meanings for comprehensive treatment of weed resistance, and has huge economic benefit and social benefit.

The invention discloses a yellow wine rice milk reusing method. The method comprises the following steps of: a, guiding rice milk obtained by soaking rice in a yellow wine brewing process to a storage tank for storage, and placing the rice milk for certain time so that certain sediments settle naturally; b, introducing the naturally settled water in the storage tank into a container for placing a cylinder; c, adding a flocculating agent into the water incompletely consumed in the step b into the storage tank, and introducing the settled clear water into the rice soaking container; and d, introducing the silt obtained by settling in the step c out for brewing wine or animal feed. In the step a, the rice milk is placed in the storage tank for 36 to 48 hours. According to the yellow wine rice milk reusing method provided by the invention, the rice milk generated in the yellow wine brewing process is reused, the consumption of the flocculating agent is greatly reduced, the cost is saved, and the environment is protected; and because the generated rice milk is not directly discharged to the external environment, zero discharge of rice milk pollutants is realized.

The invention discloses an oxine-copper and validamycin compound pesticide composition and a preparation method and application thereof, belonging to the field of crop protection. The pesticide composition comprises 1-90 parts of active ingredients by weight and 10-99 parts of pesticide carrier by weight, wherein the active ingredients include oxine-copper and validamycin at a weight ratio of (0.1-90):(0.1-60). According to a great number of experiments, after the oxine-copper and validamycin are combined according to the weight ratio, an obvious synergistic effect is realized in preventing and curing fungal or bacterial diseases of plants; and the composition expands the sterilization spectrum, reduces the dosage, is safe to people and livestock and friendly to the environment, and is suitable for preventing and curing various fungal and bacterial diseases of corps such as rice, cotton, fruit trees, vegetables, tobaccos and the like.

A gel of recombinant human granulocyte-macrophage colony stimulating factor for treating ulcer, scald, burn, mucitis and mucosa wound is prepared from carbomer, propanetriol, sodium hydroxide, raw liquid, human plasma albumin, purified water, etc. Its advantages are high curative effect and low dosage.

The invention relates to a synergetic method for bacterial inhibition of ceftriaxone sodium by chitosan. According to the method, a natural nontoxic macromolecular substance chitosan is added to the commercial ceftriaxone sodium to play a synergetic effect on the bacterial inhibition of the ceftriaxone sodium. Compared with the prior art, excellent synergetic bacterial inhibition of the ceftriaxone sodium is achieved by the chitosan, thus greatly reducing the dosage of the original ceftriaxone sodium, and achieving a better bacterial inhibition effect by a lower drug concentration.

The present invention relates to medicine composition of alprostadil and Chuanhuning/Yanhuning liposome and its preparation process. The nanometer liposome medicine contains the mixture of alprostadil and Chuanhuning/Yanhuning in the weight ratio of 0.1-1.0 to 50-300 in 10.1-80.2 weight portions, the mixture of soybean lecithin and yolk lecithin in the weight ratio of 4 to 1 in 88-440 weight portions, the mixture of cholesterol and beta-sitosterol n the weight ratio of 9 to 1 in 40-200, polyethylene glycol in 4000 15-40 weight portions, sodium glucuronate in 100 -280 weight portions and vitamin C in 160-800 weight portions. The medicine of the present invention may be used in antagonizing pneumonia adenovirus and influenza virus.

The invention discloses a pesticide composition with flufiprole and benzoylurea insecticide. The effective components are flufiprole and benzoylurea insecticide, the benzoylurea insecticide is one of chlorbenzuron, hexaflumuron and chlorfluazuron, the weight ratio of the flufiprole to benzoylurea insecticide is (1:20)-(20:1), the weight percentage of the weight summation of the flufiprole and the benzoylurea insecticide in the composition is 2-80%. The pesticide composition disclosed by the invention is used for preventing and controlling vegetable plutella xylostella. The preventing and controlling effect of the pesticide composition is obviously improved in comparison with that of a single agent, the use dosage of the pesticide is lowered, the influence on the environment caused by the pesticide is reduced, and the drug use cost is lowered.

The invention provides a weeding composition containing mesotrione and propanil, the active ingredients of the weeding composition comprise mesotrione and propanil, and the mass ratio of mesotrione to propanil is (0.1-10): (1-100); and preferably, the ratio is (0.1-10): (1-60). The weeding composition can be used for preventing and removing annual and partial perennial weeds in paddy fields, and has a remarkable synergistic effect.

The invention discloses a traditional Chinese medicine composition for external use and application thereof. The composition is prepared by processing the following traditional Chinese medicinal raw materials by weight: 40 to 80 parts of Maoyanmei, 10 to 30 parts of sophora flower and 10 to 30 parts of large-flowered skullcap root. The extracts of Maoyanmei, sophora flower and large-flowered skullcap root are added into a buffer solution with a pH value of 5 to 7, then a proper amount of organic alkaline substances are added, and vibration dissolving is carried out so as to obtain the composition. The traditional Chinese medicine composition provided by the invention has higher bacteriostatic, anti-inflammation, pain-relieving and antioxidative effects, can be applied to transdermal drug delivery preparations and cosmetics and exerts treatment effects on acne and angular cheilitis. According to the invention, the application dosage of the composition can be reduced, the composition has small side-effects, generation of precipitates and color changes of the composition can be reduced, and skin permeation of the composition and performance of drug effects are effectively promoted.

The invention discloses a medicine for colonoscopy and intestine tract preparation before colonic and rectal surgeries. The medicine is a medicinal combination containing L-glucose and L-mannose. The L-glucose and the L-mannose are not required to be separated, so the production cost is reduced; and the method has high industrial value. The medicinal combination of the L-glucose and the L-mannose has the characteristics of safety, reliability, convenience for use, good patient compliance and the like.

The invention discloses a bactericidal composition containing fluopyram and difenoconazole and application thereof, wherein the bactericidal composition contains fluopyram and difenoconazole as active components in weight ratio of 20: 1 to 1: 20. The weight percentage of total weight of the fluopyram and difenoconazole is 10-70% of the bactericidal composition. The bactericidal composition is used for preventing and controlling powdery mildew of cucumber. The composition is of obvious synergistic action in comparison with single component, which can reduce use dosage and use frequency of the pesticide, reduce dose cost and bad influence to entironment. The composition is safe to crops and plays an important role in comprehensively treating disease resistance.

The invention discloses an herbicidal composition applicable to a potato field. The herbicidal composition contains cyclo-oxadiargyl and pendimethalin which serve as active ingredients, wherein a ratio of cyclo-oxadiargyl to pendimethalin is equal to (1:20) to (20:1) in parts by mass, and the total mass of cyclo-oxadiargyl to pendimethalin accounts for 20%-80% of the mass of the composition. Depending on application demands, the herbicidal composition disclosed by the invention can be prepared into water dispersible granules, wettable powder, an emulsion in water or in other application dosage forms applicable to agricultural use; the herbicidal composition is suitable for preventing and removing annual weeds of the potato field, and has a weeding effect significantly better than that of single cyclo-oxadiargyl or single pendimethalin; a weed controlling spectrum is widened, a dosage is reduced and disease resistance of weeds is delayed.

The invention discloses a pesticide composition containing agritol and metaflumizone. The pesticide composition comprises common auxiliaries, the agritol and the metaflumizone, wherein the weight part ratio of the agritol to the metaflumizone is 20:1-1:20, and the weight sum of the agritol and the metaflumizone accounts for 1 to 60 percent of the weight percentage of the pesticide composition. The auxiliaries are one kind or several kinds of materials from solvents, emulsifying agents, wetting agents, stabilizing agents, dispersing agents, thickening agents, pH regulating agents, defoaming agents, antifreezing agents and fillings. The pesticide composition is used for preventing and treating crop lepidoptera type insects, and has the advantages that the quick acting effect and the persistence are better than those of single dosages, in addition, the use dosage of pesticide is reduced, the pesticide consumption cost is reduced, and the comprehensive treatment of environment protection and agricultural insects is favorably realized.

The invention provides a bounce-resistant fluazinam suspension agent. The bounce-resistant fluazinam suspension agent comprises: fluazinam, a wetting agent, a dispersing agent, a thicker, a preservative, an antifreezing agent, a suspending assistant, a defoaming agent, a bounce-resistant agent, a bounce-resistant synergist and water. The preparation method of the bounce-resistant fluazinam suspension agent comprises the process steps of mixing, sanding and the like. The particle size of the suspension agent is controlled to be 5 mum or below, and the suspension ratio is more than 90%. The preparation has the characteristics of low dynamic surface tension, good bounce resistance, strong adhesion and the like, and the bounce loss of a fluazinam solution can be reduced on surfaces of leaves,so that the utilization rate of the pesticide is improved greatly, and the dosage of the pesticide is reduced under the condition of ensuring the same pesticide effect; in addition, the cost of pesticide application of a farmer is reduced, and pollution to the environment is reduced.

The invention provides a pesticide composition and application thereof. Active constituents in the composition are butene-fipronil and pyridaben; and the composition is suitable to control pests and pest mites in agriculture. The pesticide composition has the following advantages: (1) the composition shows excellent synergy effect within certain range of mixture ratio, the insecticidal effect of the composition is obviously improved than single pesticides, using dosage of pesticides as well as pesticide application labor and cost are reduced at the same time, and the adverse effect on the environment and the pesticide residue are also reduced; (2) the two effective constituents in the composition have different action mechanisms, and the application of the composition can prolong or overcome the drug fastness of the pests, and prolong the service life of the single pesticides; and (3) the composition can control the pests and can control pest mites synchronously.

The invention provides an insecticidal bactericidal composition containing thiamethoxam, pyraclostrobin and triazole. The composition is characterized by including, by mass, 1%-20% of thiamethoxam, 0.1%-5% of pyraclostrobin and 0.1%-5% of triazole. The insecticidal bactericidal composition is used for controlling crop diseases and insect pests.

The invention relates to a solution preparation for aerosol inhalation for treating child cough, and belongs to the field of pharmaceutics. The solution preparation for aerosol inhalation for treating child cough comprises effective constituents, an isotonic agent and a solvent, also may including a buffer. According to the solution preparation, the gap of the current domestic market is filled; moreover, the solution preparation is specially designed for patients need aerosol inhalation and is matched with a nebulizer in use, and use process is convenient; compared with a child lung-heat cough oral liquid, the administration route is different, the using dosage is reduced, and the safety is improved.

The invention belongs to the field of the pharmaceutics technology, and particularly relates to a honeysuckle flower and radix scutellariae solution preparation for inhalation and a preparing method thereof. The honeysuckle flower and radix scutellariae solution preparation for inhalation comprises a first extract, a second extract, an auxiliary and a solvent. The first extract is prepared by extracting honeysuckle flower, leaves of panax notoginseng and houttuynia cordata, and the second extract is prepared by extracting radix scutellariae. The honeysuckle flower and radix scutellariae solution preparation for inhalation is safe, effective, high in bioavailability, small in use dosage, rapid in effect, good in treatment effect and free of other toxic and side effects; the preparation is given to a patient through atomized inhalation, the medicine is directly transmitted to a respiratory tract, absorption is rapid, and acting is rapid; the first-pass effect and gastrointestinal tract degradation can be avoided, the medicine concentration of a focus part is increased, the dosage of administration is reduced, the distribution of the medicine in other tissue is reduced, and side effects of the medicine are reduced.

The invention discloses a method for reducing insulin dosage of a diabetic patient by applying stem cell therapy. According to the method, the bone marrow mesenchymal stem cells in the body of a diabetic patient are separated and amplified; mature bone marrow mesenchymal stem cells are cultured; then, the mesenchymal stem cells are transfused and injected back to the diabetic patient; the dosage of insulin for the diabetic patient is reduced; intravenous injection is adopted in a reinfusion mode, the average quantity of the mesenchymal stem cells injected into each patient each time is 11.2 *10 < 10 >; the injection is carried out once every 10 days, the dosage of insulin is gradually reduced for a diabetic patient after each time of reinfusion, the total number of times of reinfusion is8-10, and the number of times of reinfusion is increased according to the illness state of the diabetic patient until the diabetic patient do not need insulin. The stem cell therapy makes a breakthrough in reducing the insulin dosage of diabetic patients, stem cell transplantation experiments are carried out on 15 diabetic patients, and results show that 13 patients get rid of insulin dependence.

The invention provides a compound insulin preparation, which is an oral administration oil preparation prepared by dissolving combined tetrodotoxin and insulin in medical or edible oil, wherein the insulin content is between 0.5 and 10 U/ml, and the tetrodotoxin content is between 0.01 and 10 mu g/ml. In the compound insulin preparation, a trace amount of tetrodotoxin and insulin are combined to form a compound oral administration oil-phase preparation for the defects of the side effect and administration mode of the insulin, so the trouble and flesh bitterness caused by injecting the insulinevery day are prevented, and the side effect of the insulin can be reduced or eliminated.

The invention belongs to the field of medicines, and relates to a pharmaceutical composition containing lorcaserin and a medical application of the pharmaceutical composition, in order to overcome the deficiencies in the prior art that lorcaserin has a large adverse reaction in an obesity treatment process, and the effect of continuously losing weight is not good. The pharmaceutical composition has definite treatment effect and small adverse reaction when applied to obesity treatment, and has good therapeutic action on a metabolic syndrome, and good clinical application prospects.

The invention discloses an antibacterial healing-promoting wound dressing and a preparation method thereof, and relates to the technical field of medical dressings. The antibacterial healing-promotingwound dressing comprises an effective substance and a wound dressing matrix, wherein the effective substances comprise 0.001-0.5% of otinidine and 0.1-5% of a traditional Chinese medicine extract, and the wound dressing matrix comprises 0.5-8% of a thickening agent, 0.1-10% of an emulsifying agent, 0.002-20% of an oil phase, 0.001-1% of a chelating agent and the balance of water. The antibacterial healing-promoting wound dressing disclosed by the invention is small in dosage, and obvious in effects of inhibiting the growth of wound bacteria and preventing infection; the wound dressing is goodin film-forming property and thin in formed film; the wound dressing is convenient to spray and smear, and meanwhile, the functions of wound disinfection and protection are achieved; no pricking feeling of an organic solvent is caused, the mildness is realized, and the compliance is good.

The invention discloses a sterilization composition containing benziothiazolinone and flumorph. The sterilization composition contains effective ingredients, namely benziothiazolinone and flumorph. The weight ratio of benziothiazolinone to flumorph is (1-20):(20-1), and the total weight of benziothiazolinone and flumorph accounts for 5-90% of the weight percent of the composition. According to practical application requirements, the composition containing benziothiazolinone and flumorph can be prepared into one of water suspension, microcapsule suspension, emulsion in water, micro-emulsion, ultra-low volume liquid, wettable powder and water dispersible granules, and is used for preventing and treating cucumber downy mildew.

The invention discloses a herbicide composition for preventing and eliminating weeds of a paddy field and a use thereof, in particular to a herbicide for preventing and eliminating grass weeds, broad-leaf weeds and sedge weeds in the paddy field. The herbicide is a three-element mixture consisting of metamifop, benzobicylon and methoxone. The weight ratio of metamifop to benzobicylon to methoxon in the composition is (1 to 15): (1 to 20): (2 to 60) and preferably 5:10:40. The compound herbicide composition is used for preventing and eliminating weeds of the paddy rice, and is reasonable in components, the prevention effect is better than the activity of each component used independently, the herbicidal spectrum of the weeds can be enlarged, the prevention cost can be reduced, the weed resistance can be retarded, the safety for crops is good, and the safety requirement of the pesticide preparation can be met.