86 results about "Penetration enhancer" patented technology

The invention discloses a preparation method of EVOH, and relates to the technical field of EVOH. According to the method, a low-temperature (0-5 DEG C) methanol-n-hexane mixed solvent system is creatively adopted and matched with a penetration enhancer to realize synergistic extraction, so that synchronous and deep removal of polar and non-polar small molecular impurities in the EVA is finally realized, the content of impurities in the EVA is remarkably reduced, and the self-polymerization reaction of residual monomers is effectively inhibited; therefore, a key guarantee is provided for subsequent preparation of high-quality EVOH products. The film processed by the EVOH prepared by the invention has the characteristics of few crystal points and high product quality, and can be applied to the field of high-barrier packaging film materials.

The present invention relates to a pharmaceutical composition for oral administration comprising a GLP receptor agonist or a pharmaceutically acceptable salt or derivative thereof, one or more penetration enhancers, one or more mucous membrane adhesives, and one or more basifying agents. More preferably, the penetration enhancer is a penetration enhancer based on medium chain fatty acids.

The invention provides a hair care composition with oil control, hair loss prevention and repair effects and a preparation method of the hair care composition, and belongs to the technical field of hair care. The hair care composition comprises functional peptides such as myristoyl pentapeptide-4, palmitoyl tripeptide-1, acetyl tetrapeptide-3, hexapeptide-3, acetyl hexapeptide-8, palmitoyl tetrapeptide-7 and the like which are synergistically combined according to a specific proportion, and glycerin, water and a penetration enhancer are supplemented to form a basic system. By optimizing peptide structure modification, adding proportion and the steps of pH control, ultrasonic treatment and collaborative assembly in the preparation process, multi-path collaborative regulation and control of hair follicle activation, scalp inflammation inhibition and keratin synthesis enhancement are realized.

The invention relates to the technical field of skin care product raw materials, and particularly discloses a composition for controlling oil and removing acne and application thereof. The composition for controlling oil and removing acne comprises the following components in parts by mass: 3.2478-5.413 parts of a humectant; 3-5 parts of a penetration enhancer; 0.0072 to 0.012 part of a preservative; 3.1164 to 5.194 parts of a composite extract product; 2.6286 to 4.381 parts of a solvent; the composite extract is prepared by compounding a lotus corniculatus seed extract, a yeast extract, a rosa multiflora flower extract and a parsley flower extract. The acne-removing mask has the advantage of further improving the acne-removing effect.

The invention relates to the related technical field of dispergators, in particular to a compound dispergator for ceramic cultural relics and a preparation method of the compound dispergator for the ceramic cultural relics, and the compound dispergator for the ceramic cultural relics is composed of a main solvent I, a main solvent II, a penetration enhancer, a pH buffering agent, a thickening agent and a surfactant, wherein the main solvent I is 40-70 parts, the main solvent II is 5-10 parts, the penetration enhancer is 5-15 parts, the pH buffering agent is 0.5-2 parts, the thickening agent is 0.5-2 parts, and the surfactant is 1-4 parts. The special dispergator for the ceramic cultural relics and the preparation method of the special dispergator have the following remarkable advantages of high efficiency and broad spectrum: through compounding of the two main solvents and the penetration enhancer (NMP), a synergistic effect is formed, various stubborn adhesives from cyanoacrylate to cross-linked epoxy resin and the like can be effectively treated, the removal efficiency is high, and the action time is short. The preparation method has the advantages of simple process, excellent safety, controllable operability and environmental friendliness, the whole preparation process is carried out at normal temperature and normal pressure, no special equipment is needed, the process is simple, the reproducibility is good, and standardized production is easy to realize.

The present application relates to the technical field of microneedle transdermal drug delivery, and particularly relates to a transdermal drug delivery patch and a penetration promoting patch assembly. The transdermal drug delivery patch comprises a driving device, the driving device comprises an elastic air bag, a pressure generating unit and a pressure limiting valve, the pressure generating unit is connected with the elastic air bag, is used for increasing the internal air pressure of the elastic air bag and making the elastic air bag expand, the pressure limiting valve is arranged on the elastic air bag, and is opened only when the air pressure in the elastic air bag exceeds a threshold value, is used for reducing the internal air pressure of the elastic air bag and making the elastic air bag shrink; the patch further comprises a dredging device, the dredging device comprises a substrate, one side surface of the substrate is in contact with the elastic air bag, and a dredging unit capable of treating the skin is arranged on the other side surface of the substrate; the dredging unit can repeatedly touch the skin in the process that the elastic air bag repeatedly expands and shrinks. The present application can effectively improve the absorption effect of the skin on active ingredients, and simultaneously reduce the operation and learning difficulty.

The application discloses an ant-termite drug barrier system for wood composites and a construction method and application thereof, and relates to the technical field of wood composite ant-termite prevention. The ant-termite drug barrier system comprises a drug active ingredient, a nanoscale modified silicon dioxide carrier, a penetration enhancer, an adhesion enhancer and a stabilizer, and the drug barrier can be efficiently constructed on the surface of the wood composite by a vacuum-assisted impregnation method, and the thickness is controllable and the operation is convenient. The nanoscale modified silicon dioxide carrier is combined with a complex system of sodium fatty alcohol polyoxyethylene ether sulfate and alkyl polyglycoside, so that the permeability and adhesion can be significantly improved. The system is suitable for indoor and outdoor environments, can be coated with a waterproof coating to prolong the service life, and can be conveniently repaired when locally damaged; the drug active ingredient is non-toxic or low-toxic, so that an efficient, durable and environmentally-friendly ant-termite solution for wood composites is provided.

The application belongs to the technical field of biological medicine, and particularly relates to a composite material containing a local anesthetic and a preparation method thereof. The composite material containing the local anesthetic comprises the following raw materials in parts by weight: bupivacaine hydrochloride 10-15 parts, a light-heat conversion agent 4-8 parts, delta-cadinene 0.5-1 part, a penetration enhancer 1-3 parts, and glycerol 2-5 parts. The light-heat conversion agent and the bupivacaine hydrochloride are added in combination, so that the discomfort caused by photothermal therapy is relieved. The delta-cadinene and the bupivacaine hydrochloride are combined, so that the analgesic effect is improved, the analgesic time is prolonged, the pain caused by frequent dressing change is avoided, and the toxic side effects caused by the accumulation of blood drug concentration are avoided. In addition, the penetration enhancer composed of egg membrane protein peptide and polylysine is introduced, so that the absorption of the effective components by the skin is further promoted, and the analgesic effect is quickly exerted.

The application discloses an aerosol and a preparation method and use thereof. The application unexpectedly realizes the synergy and balance of multiple advantages such as rapid onset, long-lasting, accurate dosage and uniform atomization by creatively combining a local anesthetic drug with a specific penetration enhancer, a film-forming agent and a mixed propellant system, and provides an excellent solution for the treatment of premature ejaculation.

This invention belongs to the field of patch technology and relates to a sleep-aiding and hypnotic transdermal patch and its preparation method. The sleep-aiding and hypnotic transdermal patch includes a drug-loaded layer, which, by weight, comprises 2-9 parts of active drug and 0.1-7 parts of a penetration enhancer. The penetration enhancer is a combination of menthol and essential oil; the weight ratio of menthol to essential oil is 1-4:0.1-3. This invention, through optimizing the formulation and preparation process, successfully prepares a sleep-aiding and hypnotic transdermal patch with good permeability and stability, enabling slow release and absorption of the drug, solving the problems of insomnia and poor sleep quality; and reducing the probability of side effects while improving the therapeutic effect.

The present application relates to a kind of anti-hair loss essence containing kudingcha ilex extract and its preparation method, kudingcha ilex extract is added in anti-hair loss essence, anti-hair loss essence can show the effect of promoting hair growth and inhibiting hair loss after use;Anti-hair loss essence also includes lactobacillus fermentation product and penetration enhancer;Lactobacillus fermentation product is used as conditioner, can improve the microenvironment of scalp, and cooperates with kudingcha ilex extract to improve the condition of hair loss;In addition, through the effect of penetration enhancer, the absorption degree of scalp to kudingcha ilex extract and is improved.

The application provides a dexmedetomidine hydrochloride soluble microneedle; the dexmedetomidine hydrochloride soluble microneedle comprises a substrate and a drug-loaded needle body, the drug-loaded needle body comprises dexmedetomidine hydrochloride and a penetration enhancer; the penetration enhancer comprises at least two of laurocapram, polyvinylpyrrolidone and polysorbate; the weight average molecular weight of the polyvinylpyrrolidone is 2000 Da to 13000 Da. The dexmedetomidine hydrochloride soluble microneedle provided by the application can significantly improve the peak drug concentration after transdermal delivery under the promotion of the penetration enhancer, has a short onset time and a long duration, and can achieve the effects of rapid release, rapid onset and sustained effectiveness.

The invention belongs to the field of transdermal drug delivery materials, and provides a high-molecular sustained-release material for sleep disorders and a preparation method of the high-molecular sustained-release material. The design that a star-shaped polyurethane-silane prepolymer is self-assembled in an ethanol-water mixed solvent to form nano-micelles, melatonin is loaded, and a Si-O-Si cross-linked stable structure is formed on a shell layer through hydrolytic condensation of triethoxysilane is adopted, the median particle size of the obtained nano-dispersion system is 80-200 nanometers, the drug loading capacity is 5-20%, and the stability of the melatonin is improved. And propylene glycol is used as a penetration enhancer to form a coating transdermal drug delivery preparation. The synergistic improvement of low viscosity, coating processability, shell crosslinking stability, drug sustained release and transdermal permeability under high solid content is realized. The problem that an existing nano-micelle film-forming type percutaneous dispersion system is difficult to give consideration to coupling contradictions of a processing window, drug release permeability and safety is solved, and the nano-micelle film-forming type percutaneous dispersion system has wide application value in the field of sleep disorder percutaneous treatment.

This application relates to a biphasic lipid vesicle pharmaceutical composition comprising a lipid bilayer comprising vesicle-forming lipids, an oil-in-water emulsion stabilized by one or more surfactants, one or more compounds, and one or more penetration enhancers. The one or more penetration enhancers include one or more non-ionic surfactants having a hydrophilic-lipophilic balance (HLB) of about 10 or less, alone or in combination with one or more penetration enhancers selected from one or more of terpenes, alkaloids, salicylate derivatives, and polycationic surfactants, and combinations thereof. This application also relates to a pharmaceutical composition comprising a biphasic lipid vesicle comprising a lipid bilayer, the biphasic lipid vesicle comprising a vesicle-forming lipid, an oil-in-water emulsion stabilized by one or more polycationic surfactants, and one or more compounds.

This invention provides an aqueous dewaxing reagent comprising the following components by weight percentage: 0.3-6% surfactant and 0.5-3% composite penetration enhancer, with the balance being water. The composite penetration enhancer is composed of limonene and terpineol, wherein the mass of terpineol is not less than 10% of the total mass of the composite penetration enhancer. The preparation method involves mixing the surfactant, composite penetration enhancer, and water. This invention utilizes a composite penetration enhancer composed of limonene and terpineol, which significantly improves dewaxing speed, reduces temperature dependence, widens the operating temperature window, reduces tissue damage, provides better protection against antigens, and is beneficial for IHC staining.

The invention discloses a quintuple VC (Vitamin C) nano-liposome composition and a preparation method thereof. The composition has a unique core-shell structure, wherein an inner core of the composition is a stable compound formed by a quintuple VC active system extracted through biological fermentation of kiwi fruits and cationic polysaccharide through electrostatic interaction; and the shell is a lipid bilayer membrane formed by self-assembly of phospholipid, cholesterol and a glycoside surfactant. The quintuple VC active system is a synergistic system and comprises five functional components including prototype VC, a VC derivative, a VC endogenous synthesis precursor, a VC natural protective agent and a VC penetration enhancer. The core of the preparation method is as follows: firstly, a VC-polysaccharide compound nano dispersion is prefabricated through a microjet technology to serve as an inner core; injecting the warm W / O type colostrum into a low-temperature bulk water phase by utilizing a temperature difference triggering type self-assembly technology, and instantaneously triggering lipid to encapsulate the inner core to form the nano-liposome; and finally, carrying out continuous purification and concentration through online tangential flow ultrafiltration.

The present application relates to the field of medicine biology, and particularly relates to a transdermal patch containing dexmedetomidine. By adding a penetration enhancer, the transdermal rate and the permeation amount are improved, the onset time is shortened, the patch content is reduced, the skin residue is reduced, and the skin redness / scarring at the administration site caused by the accumulation of the drug in the skin is effectively avoided.

A method in accordance with a particular embodiment of the present invention includes increasing a concentration of a modified or unmodified saccharide within a subject's skin, applying an applicator to the subject's skin, and cooling the subject's skin via a heat-transfer surface of the applicator. The saccharide within the subject's skin can enhance a resistance of at least some cells within the subject's skin to damage associated with the cooling. A corresponding system includes the applicator, the saccharide, and an energy-delivery device. The energy-delivery device can be configured to apply ultrasound, optical, thermal, or another type of energy to the subject's skin to drive the saccharide into the subject's skin. The system can also include a penetration enhancer configured to enhance penetration of the saccharide into the subject's skin. The penetration enhancer can be applied with the saccharide or separately.

A method for conditioning hair comprising applying to the hair a composition comprising: a) at least one water soluble penetration enhancer selected from the group consisting of C2-C8 monoalcohols; b) a nonionic surfactant; and c) at least one carboxylic acid of formula (I) and / or a salt thereof: R1-N-(CH (R2) COOH) 2 (I) wherein:-R1 represents a hydrogen atom or a group-CH (COOH)-(CH2) 2-COOH,-CH2CH2OH,-CH (CH3) COOH,-(CH2) 2N (COR3)-CH2-COOH or-CH (COOH)-CH2-COOH; and when R1 represents a hydrogen atom, R2 represents a CH2COOH group, or when R1 is a group other than a hydrogen atom, R2 represents a hydrogen atom; and-R3 represents a linear or branched alkyl group comprising 1 to 4 carbon atoms or a cycloalkyl group comprising 3 to 30 carbon atoms.

The invention discloses efficient deep penetration acid liquor as well as a preparation method and application thereof. The efficient deep penetration acid liquor comprises the following components in parts by mass: 20-35 parts of a main acid agent, 5-15 parts of a penetration enhancer, 2-6 parts of a corrosion inhibitor, 2-5 parts of a stabilizer and 40-70 parts of deionized water, wherein the main acid agent is a compound of main acid and auxiliary acid, and the penetration enhancer is a compound of fatty alcohol-polyoxyethylene ether and sodium lauroyl sarcosinate. Main body acid (one or two of sulfamic acid and chloroacetic acid) and auxiliary acid (one or two of formic acid and acetic acid) are compounded to serve as a main acid agent, and the main acid agent is combined with a penetration enhancer compounded by fatty alcohol-polyoxyethylene ether and sodium lauroyl sarcosinate, a corrosion inhibitor and a stabilizer. The core goals of deep penetration and low corrosion are jointly achieved, and the method can be applied to various scenes such as soil improvement, oil and gas exploitation and industrial equipment cleaning in a cross-field mode.

The invention provides a method for detecting magnet attracts in talcum powder, and belongs to the technical field of magnetic substance detection.The detection method comprises the following steps that S1, talcum powder is added into water, absolute ethyl alcohol is added after stirring, and a mixed solution is obtained; s2, adding a dispersing agent into the mixed solution, adjusting the pH value to 8-9, and heating and stirring to obtain a dispersion solution; s3, the dispersion liquid is filtered, washed and dried, and pretreated powder is obtained; s4, dispersing and spreading the pretreated powder, and adsorbing with a magnet for detection; wherein the dispersing agent is composed of a penetration enhancer and a surface treating agent. The detection method provided by the invention has the characteristics of simplicity in operation, high detection efficiency and good repeatability, can accurately detect the content of the magnet attractant in the talcum powder body, and effectively improves the detection efficiency and the detection quality.

Provided herein are topical pharmaceutical compositions of midostaurin or a pharmaceutically acceptable salt thereof and optionally a penetration enhancer (e.g., terpenoid such as menthol). Further described are methods for preparing such topical pharmaceutical compositions and methods of using the same for treating a subject.

The invention discloses an animal collagen oral soluble membrane and a preparation method thereof, and relates to the technical field of traditional Chinese medicines and medicinal and edible preparations. The animal collagen oral soluble membrane comprises animal collagen, a filling agent, an adhesive, a penetration enhancer, a plasticizing forming agent and a seasoning component, and the animal collagen is prepared by the following steps: stirring a solution containing pepsin and diluted hydrochloric acid and the animal collagen in deionized water, then adjusting the pH value to 8-9 by using a sodium dihydrogen phosphate buffer solution, centrifuging, filtering, and drying to obtain the animal collagen oral soluble membrane. The small-molecule animal collagen is obtained and placed on the tongue, the small-molecule animal collagen can be rapidly dissolved and release medicine in saliva without drinking water, the compliance of a user can be greatly improved, the preparation process has low requirements on preparation instruments and low cost, large-scale industrial production is facilitated, no or little three wastes are generated, and the requirement for sustainable development is met. Good application prospects are realized.

The invention discloses an upatinib gel plaster and a preparation method thereof, the gel plaster can improve the skin transmittance, absorptivity and stability of an upatinib gel composition through the combination of sorbitol and propylene glycol and the compounding of other components such as a penetration enhancer. The traditional Chinese medicine composition is used for treating psoriasis and arthritis, can be directly adhered to an affected part for administration, is convenient to use, reduces the influence of a gastrointestinal tract absorption way on the medicine, reduces toxic and side effects of gastrointestinal tract administration, is large in medicine loading capacity and long in acting time, and does not pollute clothes. The developed Upatinib gel plaster fills up the market blank, is convenient for patients to take, and has a wide market prospect.

The present invention discloses a composite essential oil efficacy core ball steady-state delivery system and a preparation method and application of its essence emulsion, belonging to the field of cosmetic technology. The present invention innovatively develops a composite essential oil efficacy core ball steady-state delivery system of "unstable small molecule active ingredient + biosynthetic active macromolecule + penetration enhancer molecule + functional small molecule + essential oil", which has an excellent spherical appearance, a smooth spherical surface, excellent solubility and dispersibility, and a porosity of more than 90%; when it is dispersed into the essence oil, the essence oil quickly fills the pores of the efficacy core ball to obtain the composite essential oil efficacy core ball. At the same time, the present invention also develops a full-process low-temperature production and processing technology based on liquid nitrogen quick freezing to ensure that the activity of the small molecule active ingredient is not affected by the process and to ensure the high-quality production of the efficacy core ball.

The invention provides a pharmaceutical composition as well as a preparation method and application thereof. The pharmaceutical composition provided by the invention utilizes the synergistic effect of the first penetration enhancer and the second penetration enhancer to improve the transdermal rate of AD16. By externally applying the pharmaceutical composition provided by the invention, the compliance of a patient can be improved, and the regularity of medication can be ensured.

The application relates to the technical field of skin care products, and particularly discloses a transdermal absorption whitening supermolecular composition and application thereof. The composition comprises a solvent, an external water-phase stabilizer dissolved in the solvent and whitening supermolecular particles dispersed in the solvent; the whitening supermolecular particles comprise an outer elastic liposome, the outer elastic liposome is wrapped with a water-soluble whitening agent, a water-soluble anti-glycation agent and small liposome particles; the outer elastic liposome is loaded with a penetration enhancer, a barrier repair agent and a cell autophagy activator, and the outer surface of the outer elastic liposome is also adsorbed with a keratinocyte target positioning agent; the small liposome particles comprise an inner elastic liposome, the inner elastic liposome is wrapped with a cyclodextrin-peptide amido supermolecular inclusion compound; the inner elastic liposome is loaded with an oil-soluble anti-glycation agent, and the inner elastic liposome is inlaid with a melanocyte target positioning agent. The application has the advantage of further improving the whitening effect.

The invention discloses a construction method and application of a keratin mixed lipid membrane model for screening terpenoid penetration enhancers, and the construction method comprises the following steps: embedding keratin into a lipid model, constructing a high-bionic transdermal model, optimizing guiding tension parameters by using a guiding transdermal method, balancing protein integrity and molecular penetration efficiency, and constructing a high-bionic transdermal model. The method comprises the following steps: constructing a cuticle lipid model, calculating model lipid membrane parameters, carrying out spearman correlation analysis on the lipid membrane parameters of different lipid models and cuticle retention and TEWL experimental results, and determining an optimal model in a terpene penetration enhancing process as a keratin mixed lipid membrane model for screening terpene penetration enhancers. The keratin mixed lipid membrane model constructed by the invention can be used for evaluating a keratin transmembrane model of the penetration enhancing effect of the penetration enhancer, and is applied to traditional Chinese medicine percutaneous external application, so that the time cost is reduced, and the optimal penetration enhancer is quickly screened out.

The application belongs to the technical field of transdermal patches, and particularly relates to a transdermal patch of hydrobromic acid high lappaconitine and a preparation method thereof. The transdermal patch of hydrobromic acid high lappaconitine comprises, from top to bottom, a film backing layer, a drug layer and a controlled-release film layer; the drug layer comprises hydrobromic acid high lappaconitine microcrystals and a gel body; the particle size of the hydrobromic acid high lappaconitine microcrystals is 0.5-1 microns; and the gel body comprises a gel base, a penetration enhancer, a preservative, a pH regulator and water. The transdermal patch of hydrobromic acid high lappaconitine can facilitate constant-speed and stable release of hydrobromic acid high lappaconitine.