42 results about "Penetration enhancer" patented technology

The present application relates to the technical field of microneedle transdermal drug delivery, and particularly relates to a transdermal drug delivery patch and a penetration promoting patch assembly. The transdermal drug delivery patch comprises a driving device, the driving device comprises an elastic air bag, a pressure generating unit and a pressure limiting valve, the pressure generating unit is connected with the elastic air bag, is used for increasing the internal air pressure of the elastic air bag and making the elastic air bag expand, the pressure limiting valve is arranged on the elastic air bag, and is opened only when the air pressure in the elastic air bag exceeds a threshold value, is used for reducing the internal air pressure of the elastic air bag and making the elastic air bag shrink; the patch further comprises a dredging device, the dredging device comprises a substrate, one side surface of the substrate is in contact with the elastic air bag, and a dredging unit capable of treating the skin is arranged on the other side surface of the substrate; the dredging unit can repeatedly touch the skin in the process that the elastic air bag repeatedly expands and shrinks. The present application can effectively improve the absorption effect of the skin on active ingredients, and simultaneously reduce the operation and learning difficulty.

The application discloses an ant-termite drug barrier system for wood composites and a construction method and application thereof, and relates to the technical field of wood composite ant-termite prevention. The ant-termite drug barrier system comprises a drug active ingredient, a nanoscale modified silicon dioxide carrier, a penetration enhancer, an adhesion enhancer and a stabilizer, and the drug barrier can be efficiently constructed on the surface of the wood composite by a vacuum-assisted impregnation method, and the thickness is controllable and the operation is convenient. The nanoscale modified silicon dioxide carrier is combined with a complex system of sodium fatty alcohol polyoxyethylene ether sulfate and alkyl polyglycoside, so that the permeability and adhesion can be significantly improved. The system is suitable for indoor and outdoor environments, can be coated with a waterproof coating to prolong the service life, and can be conveniently repaired when locally damaged; the drug active ingredient is non-toxic or low-toxic, so that an efficient, durable and environmentally-friendly ant-termite solution for wood composites is provided.

The application belongs to the technical field of biological medicine, and particularly relates to a composite material containing a local anesthetic and a preparation method thereof. The composite material containing the local anesthetic comprises the following raw materials in parts by weight: bupivacaine hydrochloride 10-15 parts, a light-heat conversion agent 4-8 parts, delta-cadinene 0.5-1 part, a penetration enhancer 1-3 parts, and glycerol 2-5 parts. The light-heat conversion agent and the bupivacaine hydrochloride are added in combination, so that the discomfort caused by photothermal therapy is relieved. The delta-cadinene and the bupivacaine hydrochloride are combined, so that the analgesic effect is improved, the analgesic time is prolonged, the pain caused by frequent dressing change is avoided, and the toxic side effects caused by the accumulation of blood drug concentration are avoided. In addition, the penetration enhancer composed of egg membrane protein peptide and polylysine is introduced, so that the absorption of the effective components by the skin is further promoted, and the analgesic effect is quickly exerted.

The application discloses an aerosol and a preparation method and use thereof. The application unexpectedly realizes the synergy and balance of multiple advantages such as rapid onset, long-lasting, accurate dosage and uniform atomization by creatively combining a local anesthetic drug with a specific penetration enhancer, a film-forming agent and a mixed propellant system, and provides an excellent solution for the treatment of premature ejaculation.

This invention belongs to the field of patch technology and relates to a sleep-aiding and hypnotic transdermal patch and its preparation method. The sleep-aiding and hypnotic transdermal patch includes a drug-loaded layer, which, by weight, comprises 2-9 parts of active drug and 0.1-7 parts of a penetration enhancer. The penetration enhancer is a combination of menthol and essential oil; the weight ratio of menthol to essential oil is 1-4:0.1-3. This invention, through optimizing the formulation and preparation process, successfully prepares a sleep-aiding and hypnotic transdermal patch with good permeability and stability, enabling slow release and absorption of the drug, solving the problems of insomnia and poor sleep quality; and reducing the probability of side effects while improving the therapeutic effect.

The application provides a dexmedetomidine hydrochloride soluble microneedle; the dexmedetomidine hydrochloride soluble microneedle comprises a substrate and a drug-loaded needle body, the drug-loaded needle body comprises dexmedetomidine hydrochloride and a penetration enhancer; the penetration enhancer comprises at least two of laurocapram, polyvinylpyrrolidone and polysorbate; the weight average molecular weight of the polyvinylpyrrolidone is 2000 Da to 13000 Da. The dexmedetomidine hydrochloride soluble microneedle provided by the application can significantly improve the peak drug concentration after transdermal delivery under the promotion of the penetration enhancer, has a short onset time and a long duration, and can achieve the effects of rapid release, rapid onset and sustained effectiveness.

The invention belongs to the field of transdermal drug delivery materials, and provides a high-molecular sustained-release material for sleep disorders and a preparation method of the high-molecular sustained-release material. The design that a star-shaped polyurethane-silane prepolymer is self-assembled in an ethanol-water mixed solvent to form nano-micelles, melatonin is loaded, and a Si-O-Si cross-linked stable structure is formed on a shell layer through hydrolytic condensation of triethoxysilane is adopted, the median particle size of the obtained nano-dispersion system is 80-200 nanometers, the drug loading capacity is 5-20%, and the stability of the melatonin is improved. And propylene glycol is used as a penetration enhancer to form a coating transdermal drug delivery preparation. The synergistic improvement of low viscosity, coating processability, shell crosslinking stability, drug sustained release and transdermal permeability under high solid content is realized. The problem that an existing nano-micelle film-forming type percutaneous dispersion system is difficult to give consideration to coupling contradictions of a processing window, drug release permeability and safety is solved, and the nano-micelle film-forming type percutaneous dispersion system has wide application value in the field of sleep disorder percutaneous treatment.

This invention provides an aqueous dewaxing reagent comprising the following components by weight percentage: 0.3-6% surfactant and 0.5-3% composite penetration enhancer, with the balance being water. The composite penetration enhancer is composed of limonene and terpineol, wherein the mass of terpineol is not less than 10% of the total mass of the composite penetration enhancer. The preparation method involves mixing the surfactant, composite penetration enhancer, and water. This invention utilizes a composite penetration enhancer composed of limonene and terpineol, which significantly improves dewaxing speed, reduces temperature dependence, widens the operating temperature window, reduces tissue damage, provides better protection against antigens, and is beneficial for IHC staining.

The invention discloses a quintuple VC (Vitamin C) nano-liposome composition and a preparation method thereof. The composition has a unique core-shell structure, wherein an inner core of the composition is a stable compound formed by a quintuple VC active system extracted through biological fermentation of kiwi fruits and cationic polysaccharide through electrostatic interaction; and the shell is a lipid bilayer membrane formed by self-assembly of phospholipid, cholesterol and a glycoside surfactant. The quintuple VC active system is a synergistic system and comprises five functional components including prototype VC, a VC derivative, a VC endogenous synthesis precursor, a VC natural protective agent and a VC penetration enhancer. The core of the preparation method is as follows: firstly, a VC-polysaccharide compound nano dispersion is prefabricated through a microjet technology to serve as an inner core; injecting the warm W / O type colostrum into a low-temperature bulk water phase by utilizing a temperature difference triggering type self-assembly technology, and instantaneously triggering lipid to encapsulate the inner core to form the nano-liposome; and finally, carrying out continuous purification and concentration through online tangential flow ultrafiltration.

A method for conditioning hair comprising applying to the hair a composition comprising: a) at least one water soluble penetration enhancer selected from the group consisting of C2-C8 monoalcohols; b) a nonionic surfactant; and c) at least one carboxylic acid of formula (I) and / or a salt thereof: R1-N-(CH (R2) COOH) 2 (I) wherein:-R1 represents a hydrogen atom or a group-CH (COOH)-(CH2) 2-COOH,-CH2CH2OH,-CH (CH3) COOH,-(CH2) 2N (COR3)-CH2-COOH or-CH (COOH)-CH2-COOH; and when R1 represents a hydrogen atom, R2 represents a CH2COOH group, or when R1 is a group other than a hydrogen atom, R2 represents a hydrogen atom; and-R3 represents a linear or branched alkyl group comprising 1 to 4 carbon atoms or a cycloalkyl group comprising 3 to 30 carbon atoms.

The invention discloses efficient deep penetration acid liquor as well as a preparation method and application thereof. The efficient deep penetration acid liquor comprises the following components in parts by mass: 20-35 parts of a main acid agent, 5-15 parts of a penetration enhancer, 2-6 parts of a corrosion inhibitor, 2-5 parts of a stabilizer and 40-70 parts of deionized water, wherein the main acid agent is a compound of main acid and auxiliary acid, and the penetration enhancer is a compound of fatty alcohol-polyoxyethylene ether and sodium lauroyl sarcosinate. Main body acid (one or two of sulfamic acid and chloroacetic acid) and auxiliary acid (one or two of formic acid and acetic acid) are compounded to serve as a main acid agent, and the main acid agent is combined with a penetration enhancer compounded by fatty alcohol-polyoxyethylene ether and sodium lauroyl sarcosinate, a corrosion inhibitor and a stabilizer. The core goals of deep penetration and low corrosion are jointly achieved, and the method can be applied to various scenes such as soil improvement, oil and gas exploitation and industrial equipment cleaning in a cross-field mode.

The invention provides a method for detecting magnet attracts in talcum powder, and belongs to the technical field of magnetic substance detection.The detection method comprises the following steps that S1, talcum powder is added into water, absolute ethyl alcohol is added after stirring, and a mixed solution is obtained; s2, adding a dispersing agent into the mixed solution, adjusting the pH value to 8-9, and heating and stirring to obtain a dispersion solution; s3, the dispersion liquid is filtered, washed and dried, and pretreated powder is obtained; s4, dispersing and spreading the pretreated powder, and adsorbing with a magnet for detection; wherein the dispersing agent is composed of a penetration enhancer and a surface treating agent. The detection method provided by the invention has the characteristics of simplicity in operation, high detection efficiency and good repeatability, can accurately detect the content of the magnet attractant in the talcum powder body, and effectively improves the detection efficiency and the detection quality.

The invention discloses an animal collagen oral soluble membrane and a preparation method thereof, and relates to the technical field of traditional Chinese medicines and medicinal and edible preparations. The animal collagen oral soluble membrane comprises animal collagen, a filling agent, an adhesive, a penetration enhancer, a plasticizing forming agent and a seasoning component, and the animal collagen is prepared by the following steps: stirring a solution containing pepsin and diluted hydrochloric acid and the animal collagen in deionized water, then adjusting the pH value to 8-9 by using a sodium dihydrogen phosphate buffer solution, centrifuging, filtering, and drying to obtain the animal collagen oral soluble membrane. The small-molecule animal collagen is obtained and placed on the tongue, the small-molecule animal collagen can be rapidly dissolved and release medicine in saliva without drinking water, the compliance of a user can be greatly improved, the preparation process has low requirements on preparation instruments and low cost, large-scale industrial production is facilitated, no or little three wastes are generated, and the requirement for sustainable development is met. Good application prospects are realized.

The application relates to the technical field of skin care products, and particularly discloses a transdermal absorption whitening supermolecular composition and application thereof. The composition comprises a solvent, an external water-phase stabilizer dissolved in the solvent and whitening supermolecular particles dispersed in the solvent; the whitening supermolecular particles comprise an outer elastic liposome, the outer elastic liposome is wrapped with a water-soluble whitening agent, a water-soluble anti-glycation agent and small liposome particles; the outer elastic liposome is loaded with a penetration enhancer, a barrier repair agent and a cell autophagy activator, and the outer surface of the outer elastic liposome is also adsorbed with a keratinocyte target positioning agent; the small liposome particles comprise an inner elastic liposome, the inner elastic liposome is wrapped with a cyclodextrin-peptide amido supermolecular inclusion compound; the inner elastic liposome is loaded with an oil-soluble anti-glycation agent, and the inner elastic liposome is inlaid with a melanocyte target positioning agent. The application has the advantage of further improving the whitening effect.

The invention provides temperature-sensitive poloxamer gel for preventing vaginal radiation injury and a preparation method of the temperature-sensitive poloxamer gel, and belongs to the technical field of medical gel. The temperature-sensitive type poloxamer gel is prepared from the following components: 6 percent to 18 percent of a poloxamer compound, 3 percent to 8 percent of a functional component, 0.01 percent to 0.08 percent of a penetration enhancer, 0.10 percent to 0.45 percent of a regulator, 0.13 percent to 0.25 percent of a humectant, 0.05 percent to 0.12 percent of a preservative and the balance of water, the poloxamer compound is prepared by compounding poloxamer 407 and poloxamer 188, and the poloxamer compound is prepared by compounding the poloxamer 407 and the poloxamer 188. The temperature-sensitive poloxamer gel for preventing the vaginal radiation injury, disclosed by the invention, is relatively long in retention time at an acting part, has a certain slow release effect, can keep long-time stimulation to vaginal mucosa, is beneficial to rapid healing of a wound surface, can effectively prevent radioactive vaginitis, is convenient to use, and is safe and non-irritant to a human body.

The invention belongs to the technical field of traditional Chinese medicine preparations, and discloses a preparation method of a Mongolian medicine patch. The patch is a multi-layer skeleton type transdermal drug delivery system and sequentially comprises a backing layer, a drug matrix layer and a protective layer from outside to inside, and the drug matrix layer is double-layer composite hydrogel composed of a drug storage layer and a controlled release layer; mango seeds, syzygium jambos and caesalpinia cristae serve as main medicine components, freeze-dried powder is obtained after water extraction, alcohol precipitation and freeze drying are conducted, the freeze-dried powder is mixed with a matrix containing a transdermal enhancer, and then the skin care product is prepared through the steps of sequential coating, pre-curing and the like. According to the patch, the chemical penetration enhancer is added into the matrix, so that the skin cuticle can be softened, the patch medicine is promoted to permeate into the skin, and the problem of low medicine absorption efficiency is effectively avoided.

The invention provides a transdermal analgesic patch as well as a preparation method and application thereof. The transdermal analgesic patch consists of a polyethylene glycol terephthalate backing layer, a drug-containing gel layer and a silicified polyester anti-sticking layer. The medicine-containing gel layer takes diclofenac sodium, menthol and capsaicin as analgesic active ingredients according to a specific proportion, and raw materials such as a laurocapram and L-menthol compound penetration enhancer, a blending pressure-sensitive adhesive matrix and a compound antioxidant are matched. The preparation method comprises the steps of dissolving, mixing, coating, drying, compounding and the like, and the process is mild and controllable. The patch is excellent in transdermal performance, the steady-state transdermal rate reaches up to 38.3 micrograms / cm < 2 > h, the 24-hour analgesic total effective rate is 93.3%, and the patch is good in stability and free of layering and curling problems. The traditional Chinese medicine composition can be used for preparing medicines for treating postoperative acute pain or chronic neuropathic pain, and is convenient to use and stable in effect.

A transdermal sustained-release patch for buspirone hydrochloride comprises a polyester film carrier as the backing layer, a pressure-sensitive adhesive reservoir layer prepared on the surface of the backing layer, and finally covered with a polyethylene protective film to obtain the sustained-release patch. The pressure-sensitive adhesive reservoir layer consists of a drug solution layer and an adhesive layer matrix. The drug solution layer is composed of buspirone hydrochloride, triethylamine, and glycerin, while the adhesive layer matrix is ​​composed of polyacrylate, triethylamine, a penetration enhancer, and glycerin. This invention's transdermal sustained-release patch for buspirone hydrochloride achieves a transdermal bioavailability of over 60% within 24 hours. A dose of 1.5 mg / patch achieves the equivalent effect of 10 mg orally, reducing the dosing frequency from 2-3 times daily to once daily, significantly improving patient compliance. The patch's pH value is controlled at 7.2-7.5, resulting in low skin irritation (HRIPT score ≤1.0). The process is simple, requiring no added sustained-release materials, only standard transdermal patch excipients, making production straightforward.

The application discloses a kind of tacrolimus transdermal aerosol and preparation method thereof, belong to the technical field of pharmaceutical preparation preparation.It includes the following weight parts raw materials: 63~74 complex liposome mixed solution, 22~29 weight parts propellant and 1~3 weight parts penetration enhancer.The application is obtained by mixing and pressure filling tacrolimus complex liposome solution, propellant and penetration enhancer in pressure-resistant container to obtain tacrolimus transdermal aerosol, improves the encapsulation efficiency of tacrolimus, and the prepared tacrolimus transdermal aerosol is uniform without sedimentation, with good dissolution and dispersion characteristics.

The invention relates to the technical field of medicines, in particular to a flurbiprofen organic silicon pressure-sensitive adhesive patch and a preparation process thereof. The patch is composed of a backing layer, a medicine storage layer and a protective layer, and the medicine storage layer takes an organic silicon pressure-sensitive adhesive as a matrix and comprises the following components in percentage by weight: 1-15% of flurbiprofen, 85-99% of the organic silicon pressure-sensitive adhesive and 0.5-5% of a composite penetration enhancer. The organic silicon pressure-sensitive adhesive is prepared from vinyl silicone oil, hydrogen-containing silicone oil, MQ silicon resin, a catalyst, an inhibitor and a solvent through hydrosilylation. The preparation method comprises the following steps: dissolving flurbiprofen in a composite penetration enhancer in advance, then mixing with an organic silicon pressure-sensitive adhesive system, coating and curing to prepare the patch. The patch disclosed by the invention has the advantages of high solubility of medicines in a matrix, uniform dispersion, controllable release behavior, moderate adhesion performance and good skin compatibility, can realize stable transdermal release of flurbiprofen, and is suitable for analgesic and anti-inflammatory external treatment.

Compositions and methods for treating hair loss and / or nail brittleness, fragility, and pitting, particularly in pediatric patients, using topically administered JAK / STAT inhibitors and one or more penetration enhancer are described herein.

The invention provides a macromolecular delivery system containing PDRN / DNA sodium, collagen and polypeptide, and a preparation method and application thereof, and belongs to the technical field of skin care products. The macromolecular delivery system comprises a penetration enhancer and an active matter; the penetration enhancer is prepared from hydroxyethyl chitosan and inositol. The macromolecular delivery system disclosed by the invention has a very good promotion effect on transdermal absorption of DNA sodium, collagen or a combination thereof, the cumulative permeation amount per unit area is greatly increased, and the DNA sodium, the collagen or the combination thereof is deepest delivered to a corium layer.

The present application provides a transdermal patch of agomelatine and a preparation method thereof. Specifically, the transdermal patch of agomelatine comprises (a) a backing layer, (b) an adhesive matrix layer and (c) a protective layer, wherein the adhesive matrix layer contains agomelatine and an adhesive matrix, and optionally further comprises a penetration enhancer. The transdermal patch of agomelatine prepared by the method has a fast transdermal absorption rate, a high transdermal absorption amount, and the characteristics of stability, high efficiency, good uniformity and low irritation, and the preparation method is simple.

The invention belongs to the technical field of medical nursing medical instruments, and relates to a musk-containing liquid medicine film band-aid and a preparation method thereof. According to the method, a musk substance is taken as a core, dragon's blood, frankincense, myrrh, borneol, safflower, catechu, pseudo-ginseng and free berberine are combined to form an active component, and the active component is combined with a polymer film-forming material, a plasticizer, a disinfectant, a penetration enhancer and the like to prepare a liquid wound nursing product capable of being sprayed or brushed. After the product is smeared on the surface of a wound, a layer of transparent, breathable and waterproof protective medicine film can be rapidly formed. The medical membrane not only plays a physical barrier role, but also can continuously release musk and other active ingredients, and realizes multiple effects of quickly stopping bleeding, easing pain, diminishing inflammation, promoting blood circulation to remove blood stasis and promoting healing. Compared with a traditional product, the device is suitable for irregular wounds, joints and other movable parts, and the application scene is wider; frequent replacement is not needed, and use is more convenient; edge warping is avoided, wound surface traction is avoided, and the comfort is higher.

The invention discloses a dynamic response type analgesic plaster which comprises a back plaster and a plaster body, the back plaster is of a TPEE and acrylic acid adhesive composite structure, the plaster body comprises a microcapsule and a carrier, and the microcapsule comprises a core material and a capsule wall wrapping the core material; after the microcapsule dynamically responds, the released metal ions and the drug specifically interact with the penetration enhancer in the carrier, so that the dynamic response of pressure and humidity can be realized, and a large amount of metal ions are enriched near the capsule wall in a short time period; coordination cross-linking with polymer chain segments containing functional groups such as carboxylate and phenoloxy is carried out to realize self-repairing, and balance of continuous slow release, response burst release and later recovery is achieved. Dynamic adjustment can be made according to the complex physiological environment of instant pain, continuous soreness and swelling, local moisture and repeated stress generated in a rehabilitation exercise scene, the analgesic effect is more timely and lasting than that of ointment in the prior art in rehabilitation training, and follow-up response can be achieved.

The invention discloses a high-permeability rose collagen compound for deeply repairing and whitening and tendering lip color and application thereof, the compound takes recombinant collagen, rose hip oil ceramide, rose PDRN and grape flower cell extract as functional components, and a penetration enhancer is used for improving the transdermal absorption of the collagen and other components and improving the bioavailability of the active components. The rose collagen compound disclosed by the invention has the effects of relieving, deeply repairing, whitening and tendering the lip color, resisting wrinkles, fullness and the like, and can be applied to lip cosmetics such as lipsticks, lip masks and the like.

The utility model relates to penetration enhancer accessories and instruments in the technical field of micro-needle transdermal penetration enhancement, in particular to a pressure sensing device and a penetration enhancer. The pressure sensing device comprises an outer cylinder, and a limiting groove is formed in the outer cylinder; the inner cylinder is sleeved with the outer cylinder, and a limiting buckle is arranged on the inner cylinder; the inner cylinder is also provided with a control part; an elastic piece is connected between the inner cylinder and the outer cylinder; the pressure sensing device further comprises a prompting element, a first element and a second element which are electrically connected, the first element is fixedly arranged in the outer cylinder, and the second element is movably arranged in the outer cylinder and connected with the control part; when no external force is applied, the first element is separated from the second element so that the circuit of the prompting element is disconnected. When the inner cylinder moves relative to the outer cylinder under the action of external force, the control part drives the second element to contact with the first element, and the circuit of the prompting element is switched on. The pressure sensing device can sense the contact pressure between the penetration enhancer and the skin in real time and remind a user of the use force.

The present application relates to the technical field of pharmaceutical preparation, and discloses a tulobuterol transdermal patch and a preparation method thereof.The tulobuterol transdermal patch comprises a backing layer, a paste layer and an anti-sticking layer, the paste layer comprises tulobuterol, pressure-sensitive adhesive and a penetration enhancer, the pressure-sensitive adhesive is a copolymer of 2-ethylhexyl acrylate, butyl acrylate, tertiary octyl acrylamide and methyl methacrylate, and the penetration enhancer contains propylene glycol and ethyl oleate.The present application adopts a new pressure-sensitive adhesive matrix, solves the problem that tulobuterol is easy to crystallize out in the patch, and enhances the transdermal effect of tulobuterol by using a penetration enhancer.The present application also discloses a preparation method of the tulobuterol transdermal patch, and the preparation process is improved, so that the loss of tulobuterol in the preparation process is reduced, the quality of the medicine is improved, and the cost is reduced.