63 results about "Joint pain" patented technology

The invention belongs to the field of biological products, and particularly relates to a bone glue product for preventing and treating osteoporosis and application, the bone glue comprises sheep bone glue (small molecules), pig bone glue (small molecules) and black pig bone glue (small molecules); five animals are beneficial, sheep and pigs are food beneficial to body health, bones are made into bone glue (small molecules) through modern production processes such as an enzyme preparation method and the like, the bone glue (small molecules) is easily dissolved in water and easily absorbed by a human body, can supplement colloid in the bones, is non-toxic and can be eaten for a long time; due to different yin and yang attributes, different types of osteoporosis patients can be prevented and treated; the traditional Chinese medicine also has good prevention and treatment effects on complications, fracture, hairline fracture, arthralgia and other bone diseases caused by osteoporosis; the compound can be applied to preparation of medicines, foods and health-care foods for preventing and treating osteoporosis.

This invention discloses a muscle-relaxing and meridian-clearing health powder and its preparation and application methods, belonging to the technical field of traditional Chinese medicine external health care products. The health powder is composed of fifteen raw medicinal materials: safflower, angelica, asarum, kudzu root, red peony root, scutellaria, dragon's blood, saposhnikovia root, frankincense, myrrh, cinnamon twig, mugwort leaf, coptis root, *Lycopodium clavatum*, and *Clematis armandii*. These materials are dried, pulverized to 80-120 mesh, and then evenly mixed. This invention, through a unique formulation design, integrates multiple effects such as promoting blood circulation and removing blood stasis, dispelling wind and cold, relieving muscle tension and clearing meridians, and clearing heat and drying dampness. Combined with a refined pulverization process, it significantly improves the dissolution rate and transdermal absorption efficiency of the drugs. During use, a hot compress applied via steam allows the medicinal properties to directly reach the affected area, effectively relieving pain and discomfort in the neck, shoulders, waist, legs, and joints. This invention's product has a scientific formulation, advanced technology, is convenient to use, and highly safe, possessing broad market application prospects.

The invention discloses a bone strengthening and pain relieving preparation and a preparation and use method thereof, and belongs to the technical field of traditional Chinese medicine. The preparation is prepared from unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, radix angelicae, radix cynanchi paniculati, ardisia crenata, radix salviae miltiorrhizae, cortex phellodendri, radix clematidis, peach kernels, flos carthami, cortex acanthopanacis, rhizoma drynariae, ground beetles, herba asari, short-pedicel aconite roots, borax and borneol. The auxiliary materials comprise sesame oil and minium. The prescription has the treatment rules and treatment methods of setting bones, relieving pain, clearing damp, dredging collaterals, diminishing swelling and dissipating blood stasis. The traditional Chinese medicine is mainly used for treating traumatic injury, soft tissue contusion and arthralgia, and belongs to qi stagnation and blood stasis type. The preparation is used by spreading the preparation on a non-woven fabric or oil paper. The plaster is heated and softened, and is pasted on an affected part. The traditional Chinese medicine has the symptoms of onset caused by trauma or strain, local swelling, stabbing pain, numbness of limbs, joint movement disadvantage or aggravated arthralgia when encountering wind-cold. The tongue is light, the tongue coating is thin white or white greasy, and the pulse is tight or soft.

The invention discloses application of a yang-warming and cold-dispelling traditional Chinese medicine composition in preparation of a medicine for improving cold limbs, and belongs to the field of traditional Chinese medicines. The prescription consists of folium artemisiae argyi, cassia twig, ligusticum wallichii, notopterygium root, divaricate saposhnikovia root, ginger, pepper, safflower, radix clematidis, radix aconiti carmichaeli, dried ginger and cinnamon according to a specific mass part ratio. The prescription disclosed by the invention has the effects of warming channels and expelling cold, and promoting blood circulation to remove meridian obstruction, and is mainly used for improving the symptoms such as cold hands and feet, intolerance of cold and sensation of chill, joint crymodynia and the like caused by insufficiency of yang qi and congealing cold in meridians. The invention also provides a preparation method of dosage forms such as an application agent of the prescription. Clinical tests show that the prescription preparation, especially the acupoint application agent, can obviously improve the symptoms, the total effective rate can reach 93.3%, the safety is good, and a safe, effective and convenient-to-use external treatment choice is provided for related diseases.

The invention provides a tendon-relaxing, collateral-activating and pain-relieving breast plaster for shoulder, neck, lumbar vertebra, arthralgia and traumatic injury. The plaster is prepared from the following raw materials in parts by weight: 22-35 parts of frankincense, 41-55 parts of mirabilite, 26-40 parts of ligusticum wallichii, 31-40 parts of lycopodium clavatum, 5-20 parts of dragon's blood, 5-20 parts of pseudo-ginseng, 10-25 parts of radix clematidis, 40-55 parts of pawpaw, 35-45 parts of radix angelicae pubescentis, 40-50 parts of pericarpium zanthoxyli, 40-50 parts of ginger, 30-35 parts of rhizoma drynariae, 42-47 parts of radix aconiti kusnezoffii, 43-48 parts of radix aconiti, 45-50 parts of asarum, 40-50 parts of 20 to 30 parts of chamomile, 10 to 25 parts of menthol oil, 10 to 25 parts of camphor oil, 15 to 25 parts of lavender essential oil and 10 to 25 parts of wintergreen oil; 15-25 parts of radix saposhnikoviae oil, 15-25 parts of garden balsam stem oil and 15-30 parts of safflower oil. The ointment has special effects on shoulder, neck and lumbar vertebra, arthralgia, traumatic injury, tendon relaxing, collateral activating and pain relieving; and the traditional Chinese medicine composition has the effect of treating both symptoms and root causes without relapse and side effects.

The invention belongs to the technical field of plant essential oil, and discloses gaultheria yunnanensis composite essential oil and a preparation method thereof. The essential oil comprises the following raw materials: 40-60 parts of gaultheria yunnanensis essential oil, 10-20 parts of peppermint oil and 20-30 parts of ginger oil. The gaultheria yunnanensis essential oil is used as a core raw material and matched with the peppermint oil and the ginger oil, the effects of the gaultheria yunnanensis essential oil, the peppermint oil and the ginger oil are complementary, the anti-inflammatory and analgesic effects of the gaultheria yunnanensis essential oil, the cooling and itching-relieving effects of the peppermint oil and the effects of the ginger oil for promoting blood circulation to remove blood stasis and warming channels and expelling cold are mutually matched, and the problem The compound essential oil can comprehensively relieve various discomforts such as muscle and joint pain, swelling, mosquito bite itching and chilblain, the relieving effect is better than that of existing single essential oil or conventional compound essential oil, the effective components of methyl salicylate, menthol and gingerol of the three essential oils jointly act on pain and inflammation targets, and the relieving effect is improved.

The invention belongs to the field of medical instruments, and particularly discloses a wearable hot compress device for relieving arthralgia, comprising: an internal medicine bag layer for contacting an arthralgia part; the middle wax therapy cladding is used for providing a stable and uniform hot compress environment; the external wearing layer is used for fixing the wearable hot compress device on an arthralgia part, and a rechargeable heating and temperature control device is arranged in the external wearing layer; the internal medicine bag layer is detachably connected with the middle wax therapy bag layer through a connecting part so as to be convenient to replace, and the middle wax therapy bag layer is medical paraffin wrapped by polyvinyl chloride. The external wearing layer provided with the charging type heating and temperature control device is used for heating, and the internal medicine bag layer is combined for wax therapy of medical paraffin, so that in the process of relieving pain, the effect of promoting local blood circulation through hot compress is achieved through the wax therapy; the medicine is matched and permeates to the affected part through the skin, so that the effect of reducing inflammatory factors is achieved, and the effect of fully relieving arthralgia at all positions is achieved.

The utility model provides an anti-direct-blowing structure of an air conditioner, which relates to the field of household equipment and comprises an air conditioner main unit, an anti-direct-blowing structure and a direct-blowing structure, the built-in plate is detachably arranged in the fixed screen frame; and the plurality of direct blowing prevention units are uniformly distributed on the built-in plate and are used for adjusting the airflow direction. By means of the spherical design and the universal rotation function of the air guide structure in the direct blowing prevention unit, airflow blown out of the air conditioner can be dispersed in a multi-angle and all-directional mode, cold air or hot air is effectively prevented from being directly blown to the human body, wind power can be dispersed, body discomfort such as cold and arthralgia caused by direct blowing is prevented, and the comfort level of indoor personnel is remarkably improved.

The present invention relates to the field of nutraceuticals, specifically to a synergistic bioactive composition designed to improve joint health. This composition comprises Palmitoylethanolamide (PEA) and Cucumis sativus, aimed at reducing joint pain and protecting cartilage. It addresses the complex pain components of osteoarthritis, including both nociceptive pain, which stems from ongoing joint inflammation and tissue damage, and neuropathic pain, which indicates nerve damage. This nutraceutical composition provides a novel solution for mitigating the debilitating effects of osteoarthritis through oral administration, utilizing pharmaceutically acceptable excipients to ensure efficacy and safety.

The invention discloses a small-molecule chondroitin sulfate group effect compound for interventional treatment of joint inflammation and application, relates to the technical field of joint inflammation improvement, and aims to solve the problems that small-molecule chondroitin sulfate obtained by an existing single degradation method is single in action way and difficult to comprehensively cope with the complex pathological process of joint inflammation. The composition is composed of an oxidative degradation product LMCSO, an acid degradation product LMCSA and an alkali degradation product LMCSB according to the weight ratio of 6: 3: 1, the number-average molecular weight of the three products is smaller than 10 kDa, and the composition is prepared through specific oxidative degradation, acid degradation and microwave-assisted alkali degradation methods containing a phase transfer catalyst. The small-molecular chondroitin sulfate combined-effect compound can be used for preparing medicines beneficial to repairing bone joint injuries and relieving arthralgia or stiffness.

This invention belongs to the field of rehabilitation training technology. It provides a method and system for analyzing upper limb rehabilitation training data, including the following steps: During the upper limb rehabilitation training process, static single-joint training parameter data and dynamic multi-joint collaborative training parameter data are collected in real time. The static single-joint training parameter data is then used to identify whether it meets the pain-free standard. This invention optimizes the problem of focusing only on single-joint data and ignoring multi-joint linkage and collaboration in upper limb rehabilitation training data analysis. It first identifies the static single-joint pain-free standard to eliminate basic interference, then filters and analyzes high-incidence combinations of multi-joint pain, and then reverse-engineers the final balance range where pain level meets the standard and range of motion is maximized, assessing the degree of achievement. Finally, it combines a safe expansion span to generate a stepped optimization range and predicts feasibility using a rehabilitation trend synergy index, achieving a shift from experience-driven to data-driven approaches.

To provide novel drugs effective in improving pain associated with osteoarthritis of the knee and periarthritis of the shoulder. [Solution] According to the present invention, a synovial pain reliever for arthritis is provided, comprising an endothelin A receptor antagonist as an active ingredient, wherein the arthritis is osteoarthritis of the knee or periarthritis of the shoulder. According to the present invention, it is possible to improve joint pain caused by movements that put a load on the knee joint and joint pain at rest in patients with osteoarthritis of the knee, and it is possible to improve joint pain caused by movements that put a load on the shoulder joint and joint pain at rest in patients with periarthritis of the shoulder.

Drug-loaded microspheres containing both a steroidal anti-inflammatory drug and a non-steroidal anti-inflammatory drug and injectable formulations containing the microspheres for sustained release of both drugs are disclosed. Methods of making such drug-loaded microspheres, formulations, and use of them for treating pains and inflammations, especially those caused by rheumatoid arthritis or osteoarthritis using such microspheres and formulations are also described.

The invention discloses a channel-warming, cold-dispelling and dampness-eliminating plaster for wind-cold-dampness arthralgia type osteoarthralgia and a preparation method thereof. The plaster is prepared by taking radix aconiti preparata and radix clematidis as monarch drugs, taking cassia twig, notopterygium root and radix angelicae pubescentis as ministerial drugs, taking frankincense, myrrh and safflower as adjuvant drugs and taking borneol and menthol as conductant drugs through scientific extraction and then combining with a water-based cataplasm matrix. Based on the theory of traditional Chinese medicine, the composition is precise and appropriate, the preparation process is stable, and the obtained product has the advantages of good transdermal absorption, remarkable curative effect, lasting effect, small skin irritation and the like, and is particularly suitable for symptoms such as arthralgia, swelling, unfavorable flexion and extension and the like caused by wind-cold damp evil.

The application discloses a traditional Chinese medicine micro-invasive regulating needle therapy method and belongs to the technical field of traditional Chinese medicine micro-invasive treatment, and solves the technical problems that traditional therapy for treating soft tissue pain only focuses on the local part and is difficult to solve the adhesion of deep and shallow fascia layers and has a high recurrence rate. The method takes a needle-knife as a main treatment tool, integrates a needle-knife medical theory, a fascia chain theory, a traditional Chinese medicine meridian theory and a biomechanics principle, adheres to a local relaxation + overall regulation core idea, accurately positions a treatment target through three points and one side, intervenes in inflammation-adhesion-spasm three pathological changes, follows a chain point finding and pain treatment by relaxation rule, and finally realizes a treatment goal of human body muscle and bone neutralization. The application is suitable for neck, lumbar vertebra disease, joint pain and related soft tissue lesions of head, face, spine and six big joints and has the advantages of micro-invasiveness, precision, treatment of both symptoms and root causes and low recurrence rate, and effectively restores the symmetry stability and functional coordination of the mechanical structure of the human body.

The invention discloses a massage composition for relieving muscle and neck, shoulder, waist and leg joint pain and a preparation method. The composition is prepared from pallas pit viper oil, a snow lotus herb extract, a pilose antler extract, a dragon's blood extract, garden balsam stem oil, a myrrh extract, saffron crocus oil, vanillyl butyl ether, ginger root oil, tortoise shells, menthol, frankincense oil, cetostearyl alcohol, a stearyl trimethyl ammonium chloride mixture, 2-bromine-2-nitropropane-1, 3-diol, methylparaben and water. The invention further provides a preparation method of the massage composition for relieving muscle and neck-shoulder-waist-leg joint pain and application of the composition. The massage composition for relieving the pain of the muscles, the neck, the shoulders, the waist and the legs shows remarkable effects in the aspects of relieving the pain of the muscles, the neck, the shoulders, the waist and the legs and relieving fatigue, the pain degree of a patient can be effectively relieved, and the life quality of the patient is improved.

The invention discloses a traditional Chinese medicine composition for soothing channels and activating collaterals. The traditional Chinese medicine composition comprises the following components: 2-4 parts of asiatic toddalia root, 1-3 parts of raw pinellia ternate, 1-3 parts of monkshood, 1-3 parts of radix aconiti agrestis, 1-3 parts of radix aconiti carmichaeli, 3-5 parts of safflower, 3-5 parts of asarum, 3-5 parts of angelica sinensis, 3-5 parts of ligusticum wallichii, 1-3 parts of croton root, 3-5 parts of pepper, 3-5 parts of ground beeltle, 5-7 parts of pseudo-ginseng root, 3-5 parts of radix clematidis, 3-5 parts of sappan wood, 2-4 parts of cortex dictamni, 2-4 parts of radix angelicae pubescentis, 2-4 parts of honeycomb and 2-4 parts of frankincense. , 3-5 parts of pomegranate rind, 1-3 parts of hippocampus, 1-3 parts of centipede and 1-3 parts of dragon's blood. The traditional Chinese medicine composition for relaxing the channels and activating the collaterals has the effects of relaxing the channels and activating the collaterals, dispelling wind and eliminating dampness, and relieving swelling and pain, can effectively relieve swelling and pain caused by traumatic injury, blood stasis, joint dysfunction and the like, can be used for treating diseases such as traumatic injury, rheumatic arthralgia and the like after a fracture operation, also has a certain curative effect on stroke, is sprayed or smeared on an affected part, and has no toxic or side effect. A preservative film can be used for covering, so that the pesticide effect is greatly improved.

The invention provides a nursing traditional Chinese medicine external preparation for relieving rheumatic arthralgia, and relates to the technical field of traditional Chinese medicines. On the basis of the theory of traditional Chinese medicine, a traditional Chinese medicine formula composed of pine nodular branch, ormosia henryi, shinyleaf pricklyash root, peach twig, lance asiabell root, arachnoid cyanotis root, dentiferous dendropanax root, rhizoma curculiginis, winter jasmine, wintergreen, folium cortex eucommiae, semen sesami nigrum, fructus viticis, semen allii tuberosi, rhizoma smilacis glabrae and herba menthae is prepared and used for externally treating rheumatoid arthritis in traditional Chinese medicine. The traditional Chinese medicine has the effects of promoting blood circulation to remove meridian obstruction, relieving swelling and pain, dispelling wind and eliminating dampness, tonifying liver and kidney, strengthening muscles and bones, clearing heat and promoting diuresis. The traditional Chinese medicine external preparation disclosed by the invention has excellent anti-inflammatory, detumescence and analgesic effects, has excellent performance in the aspects of improving clinical symptoms such as joint swelling, pain and pressing pain of a patient and improving sleep and joint functions, and takes effect quickly. The traditional Chinese medicine external preparation provides effective nursing means and measures for relieving or relieving rheumatic arthralgia.

The invention belongs to the technical field of knee joint arbor treatment equipment, and particularly relates to a knee joint force line appliance which comprises a body and a pressure mechanism, the body comprises a main body supporting frame, a thigh binding assembly and a shank binding assembly, and the thigh binding assembly and the shank binding assembly are in sliding connection with the main body supporting frame; after sliding in place, the main body supporting frame is fixed, and then the main body supporting frame is bound to the thigh and the shank respectively; the pressure mechanism is located between the thigh binding assembly and the shank binding assembly, and the pressure mechanism applies adjustable pressure to the key position of a force line to adjust the form of the force line of the lower limb joint, reduce and improve the development speed of gonitis lesion and reduce knee joint pain. Gradient pressure is applied to the outer side, the lower limb force line is guided to be corrected towards the outer side, and joint load redistribution is achieved. The structure of the device adopts an arc-shaped fitting design conforming to ergonomics, and it is ensured that a pressure acting point is accurately located at a key position of a knee joint force line.

A method for treating joint pain in an individual chronically afflicted with osteoarthritis, the method comprising administering to the osteoarthritis individual repeat doses of a liposomal composition comprising an effective amount of an intra-articular corticosteroid or a pharmaceutically acceptable salt thereof, in an intra-articular administration manner. A robust and long-lasting intra-articular corticosteroid treatment efficacy response is achieved for more than one year, without any signs or symptoms of adrenal insufficiency in the individual.

The invention relates to the field of medical treatment and public health, in particular to a traditional Chinese medicine formula ointment for treating osteoarthrosis pain. The first prescription is mainly composed of the following medicines: unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, asarum, artemisia rupestris, radix achyranthis bidentatae, loranthus parasiticus, cortex acanthopanacis, herba epimedii, kadsura pepper stem, cortex illicii, zaocys dhumnade, centipede, berchemia lanceolata, caesalpinia cucullata, ardisia mamillata, philippine flemingia root, whorlleaf stonecrop herb, ajuga parviflora, centella asiatica, physalis alkekengi, fructus psoraleae, rhizoma drynariae, cassia twig, rubia cordifolia and caulis spatholobi; the component II is mainly prepared from the following medicines: frankincense, myrrh, flos daturae, borneol and ferula asafetida; the invention relates to a preparation method of a traditional Chinese medicine formula ointment for treating osteoarthrosis pain. The preparation method comprises the following steps: pulverizing and filtering by using a powder screen in a formula I and a formula II, and preparing raw ointment and cooked ointment. The pharmaceutical ointment disclosed by the invention has a good curative effect, and particularly has a better treatment effect on symptoms such as swelling and pain of waist joints, neck joints, leg joints and hand joints; the traditional Chinese medicine composition is reasonable in composition, simple to use, remarkable in treatment effect and curative effect, few in side effect and environment-friendly.

The invention discloses pine-soot ink moxibustion as well as a preparation method and a use method thereof, and relates to the technical field of traditional Chinese medicine moxibustion therapy. Comprising the following raw materials: pine-soot ink, tourmaline powder, radix aconiti preparata, semen strychni preparata, sanguisorba officinalis, rhizoma corydalis, pseudo-ginseng, angelica sinensis, safflower carthamus, ligusticum wallichii, radix saposhnikoviae, gastrodia elata, frankincense, earthworm, herba epimedii, dogwood, lucid ganoderma, astragalus membranaceus, gynostemma pentaphyllum, artificial musk, wintergreen oil, borneol and beautifying wax. According to the pine-soot ink moxibustion and the preparation method and the use method thereof, the pine-soot ink is used as a substrate, the tourmaline powder is compounded, and a raw material system of multiple traditional Chinese medicines is selected, so that the product not only has the hot compress and pharmacodynamic permeation functions of the traditional Chinese medicines, but also has the adsorption characteristic of the pine-soot ink and the physical effects of negative ion release and far infrared effect generation of tourmaline; multiple synergy of a drug therapy and a physical therapy is realized, so that better health-care effects of relaxing tendons and activating collaterals, dispelling cold and removing dampness and relieving bone and joint pain are achieved.

This invention belongs to the pharmaceutical field and specifically relates to magnesium hydroxide nanoparticles for treating joint pain and a method for preparing the same. The preparation method is as follows: a soluble magnesium salt is dissolved in purified water to obtain a magnesium salt solution; a soluble metal hydroxide is dissolved in purified water to obtain a metal hydroxide solution; a phospholipid is dissolved in an organic solvent to obtain a phospholipid solution; the phospholipid solution is removed by rotary vapor deposition to remove the organic reagents; after a thin film is formed, the magnesium salt solution is added to hydrate it to obtain a hydrated solution; the metal hydroxide solution is added to the hydrated solution to perform nano-processing; and the process is completed. The preparation method is simple and easy to control, and magnesium hydroxide nanoparticles can be prepared using only magnesium salt, hydroxide, and phospholipid. Verified by rat studies, after preparing magnesium salt into nano-level magnesium hydroxide using pharmaceutical formulation technology, it has joint analgesic effects, the duration of analgesia is significantly extended, the frequency of administration is greatly reduced, and thus the patient's suffering can be reduced.

The invention discloses an external traditional Chinese medicine composition for treating joint soft tissue pain and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: 1) arisaema cum bile and radix aconiti carmichaeli; the mass ratio of the two components is (1-1.2): 1; 2) pericarpium zanthoxyli, radix aucklandiae, fructus psoraleae, rhizoma cimicifugae, cortex cinnamomi, radix angelicae, rhizoma zingiberis, ligusticum wallichii, cortex erythrinae, radix clematidis, rhizoma corydalis, szechwan chinaberry fruit and clove; the mass ratio of the thirteen traditional Chinese medicines is 1: (0.8-1): (1-1.2): 1: (1-1.2): 1: (1-1.2): (1-2): 1: (1-2): 1: (1-2): 1: 1. The mass ratio of the folium artemisiae argyi to the pawpaw is 1: (1-1.5), and the ratio of the sum of the mass of the traditional Chinese medicines in the first group, the second group and the third group is 1: 13: 3. The traditional Chinese medicine composition provided by the invention has the efficacy of improving the heat pain area of mice, and can be widely popularized and applied to arthralgia diseases clinically so as to achieve the effects of relaxing the muscles, stimulating the blood circulation and relieving pain.

1. Name of the product in this design: Packaging Box (Muscle and Joint Support). 2. Purpose of this design: For packaging pharmaceuticals. 3. The key design features of this product are the combination of pattern and color. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The design for which protection is sought includes color.

This invention relates to the field of traditional Chinese medicine preparations, and discloses a Tongli capsule and its preparation process, comprising the following raw materials: Eupolyphaga sinensis, processed Arisaema heterophyllum, vinegar-processed frankincense, vinegar-processed myrrh, dragon bone, Angelica dahurica, Lysimachia christinae, safflower, Notopterygium incisum, Angelica sinensis, Saposhnikovia divaricata, Cimicifuga foetida, Ligusticum chuanxiong, and Acorus tatarinowii; wherein, the raw materials are dried, pulverized, mixed, and then filled into capsule shells to form capsules. This Tongli capsule, using a total of fourteen traditional Chinese medicines as raw materials, follows the treatment principles of traditional Chinese medicine of dispelling wind and dampness, relaxing muscles and tendons, and promoting blood circulation and removing blood stasis. It has significant efficacy for late-stage fractures and joint dislocations, joint pain, synovitis, and other diseases caused by wind-cold-dampness obstructing the meridians. Furthermore, the capsule dosage form, with its uniform fine powder contents, makes it convenient to take, provides accurate dosage, has high bioavailability, and improves patient compliance. Compared to decoctions, capsules do not require decocting, making them easier to carry and store; compared to pills and powders, capsules can mask unpleasant odors of the medicine, and disintegrate rapidly, resulting in faster onset of action.

This invention discloses a topical ointment for treating lumbar disc herniation and vertebral joint pain, and its preparation method. The ointment is prepared from Strychnos nux-vomica, Spatholobus suberectus, Polygonum cuspidatum, Acorus tatarinowii, Clematis chinensis, white wine, Asarum heterotropoides, frankincense, myrrh, cinnamon twig, Achyranthes bidentata, Pueraria lobata, Lycopodium clavatum, and excipients honey and petrolatum. The preparation method is as follows: Strychnos nux-vomica, Spatholobus suberectus, Polygonum cuspidatum, Acorus tatarinowii, and Clematis chinensis are soaked in white wine for one year to obtain a medicinal wine concentrate; Asarum heterotropoides, frankincense, myrrh, cinnamon twig, Achyranthes bidentata, Pueraria lobata, and Lycopodium clavatum are ground into a fine powder and mixed evenly to obtain a medicinal powder; the obtained medicinal powder is moistened with the medicinal wine concentrate, and honey and petrolatum are added and mixed evenly. Existing typical clinical cases show that the ointment of this invention has no side effects, can effectively relieve the symptoms of lumbar disc herniation, and the pain disappears after use with no long-term recurrence, demonstrating significant efficacy and ease of use.

The application discloses a gradient controlled-release wax therapy traditional Chinese medicine preparation for relieving joint pain and a preparation method thereof, and belongs to the technical field of external treatment of traditional Chinese medicine. The preparation is a three-layer composite structure, and from outside to inside, the three-layer composite structure is successively a quick-release layer containing penetration promoting components, a sustained-release layer containing temperature-sensitive microcapsules and a controlled-release layer containing a gel matrix. The application embeds active / toxic medicinal materials such as aconite by using PLGA temperature-sensitive microcapsules, realizes gradient, sustained release and controlled release of the drugs under the trigger of body temperature, significantly improves the transdermal absorption rate and the clinical effective rate, and effectively reduces the blood drug peak concentration of toxic components and the risk of liver damage. The application also provides a precise temperature gradient layering casting process, and ensures that the three-layer structure is tightly combined and stable and controllable in quality. The application solves the problems of uncontrollable drug release, great toxic and side effects and poor drug efficacy persistence in the existing traditional Chinese medicine wax therapy technology, and provides a safer, more efficient and long-acting new external preparation for bone joint pain treatment.

This document presents a novel composition and method for treating osteoarthritis using a cannabinoid-based nanoplatform administered via intra-articular injection. The composition includes phytocannabinoids such as CBG and CBC, along with hyaluronic acid, type II collagen, and calcium gluconate, embedded within a nanoplatform designed to enhance bioavailability and ensure controlled release in the synovial space. Tailored for osteoarthritis patients, the treatment alleviates joint pain, stiffness, reduced mobility, inflammation, sensations of friction, muscle weakness, and joint deformity. Cannabinoids act through multiple mechanisms, including interaction with CB1 and CB2 receptors, cytokine modulation, inhibition of NF-κB, and activation of the TRPV1 receptor, providing a potent anti-inflammatory effect. The formulation aims to halt cartilage degeneration, reduce pain, and slow osteoarthritis progression. The production process uses nanoemulsification techniques to create particles smaller than 200 nm, with pre-sterilization through membrane filtration, ensuring both efficacy and safety.

The invention provides a traditional Chinese medicine composition. The invention further provides a preparation method of the traditional Chinese medicine composition. The invention further provides a traditional Chinese medicine extract and a preparation method thereof. The invention further provides a traditional Chinese medicine preparation. The invention further provides traditional Chinese medicine granules and a preparation method thereof. In addition, the invention also provides application of the traditional Chinese medicine composition, the traditional Chinese medicine extract, the traditional Chinese medicine preparation or the traditional Chinese medicine granules in preparation of medicines for treating joint adhesion after elbow joint fracture operation. The traditional Chinese medicine composition for treating the joint adhesion after the elbow joint fracture operation has the effects of expelling wind, removing cold, removing dampness, relaxing tendons, activating meridians and relieving pain, is suitable for pain, soreness, heavy, numbness and unfavorable flexion and extension of muscles and bones, muscles and joints caused by blood stasis in the later stage of fracture, obstruction of meridians and collaterals by wind-cold-dampness and unsmooth qi and blood circulation, and has the advantages of high curative effect, quick response, no toxic or side effects and the like. The cost is low; the safety is realized; no side effect exists; the use is convenient and quick.