60 results about "Glucosamine Hydrochloride" patented technology

The invention provides application of non-starch Chinese chestnut polysaccharide, the non-starch Chinese chestnut polysaccharide comprises polysaccharide CNP-1, polysaccharide CNP-2 and polysaccharide CNP-1, the weight-average molecular weight of the polysaccharide CNP-1 is 4.82 * 10 < 3 > kDa, the polysaccharide CNP-1 comprises glucose, galactose, arabinose, rhamnose, fructose, fucose, xylose and glucosamine hydrochloride, the molar ratio of the glucose to the galactose to the arabinose to the rhamnose to the fructose to the fucose to the xylose to the glucosamine hydrochloride is 0.626: 0.121: 0.084: 0.071: 0.061: 0.023: 0.011: 0.003; the polysaccharide CNP-2b has the weight-average molecular weight of 1.25 * 10 < 4 > kDa and comprises glucose, galactose, arabinose, rhamnose, fructose, fucose, xylose and glucosamine hydrochloride according to the molar ratio of (0.505): (0.161): (0.148): (0.077): (0.052): (0.025): (0.027): 0.003; the non-starch polysaccharide can regulate the intestinal flora abundance caused by colitis, improve the intestinal flora structure, maintain the intestinal steady state, relieve the injury degree of colon and ensure the body health.

The disclosure provides methods for synthesis of peracetylgalactosamine-1-pentanoic acid, also called peracetylated D-galactosamine C5 linker or GalNAc C5 linker, using a vegetal source as a starting material, such as vegetal-sourced D-glucosamine or D-glucosamine hydrochloride. Also provided are methods for purifying the peracetylgalactosamine-1-pentanoic acid, or GalNAc C5 linker, thus produced so that the end product comprises fewer impurities.

The invention relates to the technical field of biology, in particular to a composition, a culture medium and application of the culture medium in intestinal organ culture. The glucosamine hydrochloride is applied to culture of intestinal organs for the first time, organ proliferation and differentiation can be effectively promoted, and the number of formed organs is remarkably increased. On the basis, a three-dimensional culture system for staged time sequence induction in a postpartum newborn period, a child period and an adult period is constructed, and accurate construction of intestinal organs of the mice in different development periods is realized by combining dynamic regulation and control of an extracellular matrix and combinatorial optimization of growth factors; and an in-vitro model covering multiple time sequence stages is provided for intestinal development mechanism research and disease modeling.

The present invention provides a homogenized pumpkin polysaccharide and its preparation method and application, belonging to the technical field of polysaccharide extraction and purification. The homogenized pumpkin polysaccharide of the present invention contains mannose, glucosamine hydrochloride, rhamnose, glucuronic acid, galacturonic acid, glucose, galactose and arabinose, with the corresponding molar ratios being 0.005:0.004:0.041:0.013:0.545:0.004:0.241:0.147; the relative molecular weight of the homogenized pumpkin polysaccharide is 5.96×10 4 The homogenized pumpkin polysaccharide has significant lipid-lowering and blood sugar-lowering effects. The preparation method has mild process conditions and simple operation. The obtained polysaccharide has high purity and stable structure, and is suitable for industrial-scale production.

The utility model relates to the technical field of glucosamine hydrochloride, in particular to glucosamine hydrochloride post-processing equipment which comprises a coating barrel with an opening in the top, the coating barrel is connected with the lower end of a powder storage barrel, a plurality of discharging holes are formed in the bottom of the powder storage barrel, a baffle is arranged below the powder storage barrel, and a plurality of discharging holes are formed in the bottom of the powder storage barrel. A through hole matched with the discharging hole is formed in the baffle, the middle of the baffle is connected to the middle of the circumferential side face of a rotating shaft in a sleeving mode, a plurality of stirring rods are installed at the lower end of the circumferential side face of the rotating shaft, a scraper is installed on the circumferential side face of the rotating shaft on one side of the stirring rods, and the upper end of the rotating shaft penetrates through the top of the containing plate to be connected with the driving end of a rotating motor; due to the fact that the discharging holes are evenly distributed in the bottom of the powder storage barrel, powder can be evenly added, and due to the fact that the scraping plate is arranged, the scraping plate can be driven to rotate under driving of the rotating motor, scraping of the inner wall of the coating barrel is achieved, and the situation that in the coating process, the powder is prone to adhering to the inner wall of the coating barrel, and follow-up cleaning wastes time and labor is avoided.

The invention provides a glucosamine hydrochloride capsule and a preparation method thereof, the capsule content comprises the following components in parts by weight: 240 parts of glucosamine hydrochloride, 50-60 parts of starch and 2-7 parts of hydroxypropyl cellulose; the glucosamine hydrochloride capsule prepared by controlling the particle sizes of the glucosamine hydrochloride and the starch within a specific range and using a specific adhesive is high in dissolution rate (the dissolution rate in four dissolution media for 45 minutes is not lower than 85%), and the dissolution rate is stable after the glucosamine hydrochloride capsule is placed for 24 months for a long time.

To provide a composition for improving blood vessel repair function using cells.SOLUTION: This composition for improving blood vessel repair function comprises: at least one selected from the group consisting of astaxanthin, glucosamine hydrochloride, chondroitin sulfate, tocopherol, resveratrol, hesperidin (vitamin P), beta-carotene, ubiquinone, lipoic acid, zinc, arsine, arginine, citrulline, taurine, vitamin E, and mucin; and stem cells.SELECTED DRAWING: Figure 1

The invention discloses a joint health-care tablet based on glucosamine hydrochloride and sodium chondroitin sulfate and a preparation method, and relates to the technical field of medical health care. The joint health-care tablet comprises the following components: glucosamine hydrochloride, sodium chondroitin sulfate, a frankincense extract, an aesculus chinensis extract, microcrystalline cellulose, povidone, croscarmellose sodium and silicon dioxide. Through scientific proportioning of various active components such as the glucosamine hydrochloride, the chondroitin sulfate sodium, the frankincense extract and the aesculus chinensis extract, comprehensive protection of joint health is realized, the glucosamine hydrochloride and the chondroitin sulfate sodium are used as basic components, repair and regeneration of articular cartilage are promoted, and the joint health is improved. Boswellic acid compounds in the frankincense extract and aescin in the aesculus chinensis extract have anti-inflammatory and analgesic effects and can effectively relieve arthralgia and inflammation, multiple effects are synergistic, and the joint health care effect is improved.

The invention is directed to a nanostructured composite material comprising a mixture of at least one metal particle such as iron and a carbon material from biomass such as D-glucose, D-glucosamine hydrochloride or α-cyclodextrin. The invention is also directed to a composition comprising the composite material comprising the composite material and an inorganic salt, and a method for synthesizing the composite material comprising immersing the carbon material into a solution of metal ions, drying the impregnated carbon particle and subjecting the impregnated carbon particle to a carbothermal reduction process. The nanostructured composite material is useful as an oxygen scavenging layer in a multi-layer film which comprises the oxygen scavenging layer and an oxygen barrier layer that retards the permeation of oxygen from an external environment.

The invention discloses a production process of N-acetylglucosamine, and belongs to the technical field of N-acetylglucosamine production. Methanol is used as a solvent, glucosamine hydrochloride and acetic anhydride are used as raw materials, sodium hydroxide is added as a catalyst, other toxic chemical substances are not introduced, and meanwhile, the product yield is increased. In addition, in the product purification treatment process, a specific fixing agent is added, the specific fixing agent is a magnetic nanoparticle immobilized phenylboronic acid derivative, and the phenylboronic acid derivative can recognize and combine D-glucosamine with cis-dihydroxyl and cannot react with N-acetylglucosamine; the D-glucosamine in the N-acetylglucosamine can be effectively and selectively removed; and after the magnetic nanoparticles are immobilized, the selective adsorption reaction can be amplified, the separation and removal are facilitated, and the operation steps are simplified.

The present application relates to the field of biotechnology, and particularly relates to a composition, a culture medium and application thereof in intestinal organoid culture. The present application first applies glucosamine hydrochloride to the culture of intestinal organoids, which can effectively promote organ proliferation and differentiation, and significantly increase the number of organ formation. On this basis, the present application constructs a three-dimensional culture system for postpartum neonatal, childhood and adult stages, and realizes the precise construction of mouse intestinal organoids at different development stages by combining dynamic regulation of extracellular matrix and optimization of growth factor combinations, thereby providing an in-vitro model covering multiple time sequences for intestinal development mechanism research and disease modeling.

The application discloses a multi-component synovitis treatment composition based on repairing cartilage tissue and application thereof, and relates to the technical field of biological medicine, and the composition is composed of glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone and graded molecular weight sodium hyaluronate; the application precisely compounding the graded molecular weight sodium hyaluronate with the glucosamine hydrochloride, the chondroitin sulfate and the dimethyl sulfone according to weight parts, constructs a gradient slow-release and target delivery system of synovitis lesions, specifically inhibits the activity of hyaluronidase in the inflammatory joint cavity by using the dimethyl sulfone, greatly reduces the degradation of the sodium hyaluronate, prolongs the residence time of the active ingredients at the lesion site, realizes immediate analgesia and relieves joint stiffness by quickly forming a lubricating protective film by the high molecular weight sodium hyaluronate, the medium and low molecular weight sodium hyaluronate penetrates the synovial membrane barrier and carries the cartilage repair components to enrich in the cartilage defect area, and the synergistic effect of the components is realized.

The present invention discloses a glucosamine chondroitin composition and a preparation method thereof, belonging to the field of health care products. The composition comprises a turmeric extract, a drynaria extract, an eucommia extract, a rehmannia extract, vitamin K, bovine collagen peptides, chondroitin sulfate, glucosamine hydrochloride, and lactic acid calcium. The present invention achieves an excellent bone density-enhancing effect by compounding the turmeric extract, the drynaria extract, the eucommia extract, the rehmannia extract, vitamin K, bovine collagen peptides, chondroitin sulfate, glucosamine hydrochloride, and lactic acid calcium.

The utility model relates to the technical field of material drying, and discloses a drying device for preparing a glucosamine hydrochloride crude product, which comprises a heating box body, and a movable groove is formed in the front surface of the heating box body; the conveying mechanism is arranged on one side of the heating box body; the vibration mechanism is arranged in the heating box body; the collecting box is arranged in a movable groove formed in the heating box body; the handle is arranged on the front face of the collecting box. After materials fall into the vibration box, the second motor is started, the second motor operates to drive the rotating rod to rotate, the rotating rod rotates to drive the cam to rotate, when the cam moves to make contact with the vibration box, the vibration box is extruded to make the vibration box ascend, and when the cam does not make contact with the vibration box, the reset spring drives the vibration box to descend and reset. And the vibration box is vibrated by repeating the steps, so that the materials in the vibration box are vibrated, and the effect of uniformly drying the materials is achieved.

The invention belongs to the technical field of health-care food, and particularly relates to a glucosamine chondroitin bone collagen composition for improving bone and joint functions and a preparation method of the glucosamine chondroitin bone collagen composition. The glucosamine chondroitin collagen composition is characterized by being prepared from the following raw materials in parts by weight: 160 to 200 parts of calcium carbonate, 150 to 200 parts of D-glucosamine hydrochloride, 40 to 50 parts of chondroitin sulfate, 30 to 50 parts of bone collagen powder, 5 to 10 parts of hydroxypropyl methyl cellulose, 10 to 20 parts of sodium carboxymethyl starch and 2 to 8 parts of magnesium stearate. By reasonably controlling the ratio of the D-glucosamine hydrochloride to the chondroitin sulfate and the ratio of the calcium carbonate to the bone collagen powder, a better effect of increasing the bone mineral density is achieved. By reasonably controlling the content of the auxiliary materials, the product has better hardness, disintegration time limit and friability.

The utility model discloses a glucosamine hydrochloride production hydrolysis device, and relates to the technical field of hydrolysis. The outer reaction kettle comprises a plurality of supporting legs and a bottom plate fixedly connected to the tops of the supporting legs, a rotating mechanism and a plurality of configuration mechanisms are arranged on the supporting legs, the rotating mechanism comprises two supporting plates fixedly connected to the top of the bottom plate, and an outer reaction kettle is rotationally connected to the two supporting plates. Through the arrangement of the rotating mechanism, in the rotating process of the rotating shaft I, the rotating shaft I drives the rotating shaft II to drive the pinion to be meshed with the bull gear outside the outer reaction kettle through the transmission of the belt, so that the outer reaction kettle rotates, and the rotation of the outer reaction kettle drives internal heating gas to uniformly heat raw materials in the inner reaction kettle; through the arrangement, the uniform heating of raw materials in the inner reaction kettle is ensured, and the reaction rate difference caused by non-uniform heating is avoided, so that the product quality and the stability of the production efficiency are ensured.

The application discloses a kind of glucosamine hydrochloride crude product purification refining process, comprising the following steps: (1) glucosamine hydrochloride crude product is dissolved in water, then add the composite precipitant consisting of sodium chloride and sodium hydroxide, after standing, solid-liquid separation, collected separated liquid phase.(2) after the liquid phase is concentrated, add sodium percarbonate and mix evenly and stand still.After completion, pass in carbon dioxide to convert sodium hydroxide in concentrated solution into sodium carbonate, then continue to add calcium nitrate under stirring condition to make carbonate ion in system complete precipitation, i.e., the liquid to be extracted is obtained.(3) after the liquid to be extracted is cooled, add ethanol for alcohol precipitation, after completion, carry out solid-liquid separation, and the obtained solid product and separated liquid are collected respectively.The solid product is washed with ethanol and dried, and glucosamine hydrochloride finished product is obtained.The above process not only can improve the purity of glucosamine hydrochloride, but also can improve the yield of glucosamine hydrochloride in alcohol precipitation process, thereby reducing waste.

This invention relates to the field of fabric technology, specifically to a highly flexible suit coat fabric and its textile process. The fabric comprises a 2 / 2 twill cotton greige fabric and a flexible finishing layer fixed to the surface of the cotton fibers. The flexible finishing layer is formed by sequentially padding and pre-drying the greige fabric, which has undergone limited pretreatment with cellulase, with a first surface finishing solution of aldehyde-modified amylopectin / D-glucosamine hydrochloride, followed by coupling with a 3-aminopropyltriethoxysilane surface coupling solution, and a final finishing with D-glucosamine hydrochloride. The weight-average molecular weight of the aldehyde-modified amylopectin is 2.50 × 10⁻⁶. 5 -4.50×10 5 The degree of aldehyde substitution is 3.0%–7.0%. This invention enables the fabric to possess softness, washability and softness retention, tensile strength retention, breathability and moisture diffusion properties without the addition of formaldehyde resin finishing agent, making it suitable for clothing fabrics such as suits and overcoats.

The present invention relates to the technical field of natural extracts, and specifically to a camphor seed kernel polysaccharide, a preparation method thereof, and an application thereof. The camphor seed kernel polysaccharide provided in the present application comprises the following monosaccharides: glucose, mannose, galactose, arabinose, and glucosamine hydrochloride, and the molar ratio is (0.88-0.92): (0.06-0.1): (0.015-0.02): (0.003-0.004): (0.003-0.004); the weight-average molecular weight of the camphor seed kernel polysaccharide is 1000Da-20000Da. The present invention also provides a preparation method for the above-mentioned camphor seed kernel polysaccharide and an application of the polysaccharide. The results showed that camphor seed kernel polysaccharides CCSKP and CCSKP1‑A had good in vitro digestibility, and could promote the growth and reproduction of Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium infantis and Bifidobacterium adolescentis, and produce corresponding SCFAs. They had potential prebiotic activity, which was beneficial to improving the comprehensive utilization efficiency and added value of camphor seed resources.

The invention relates to an alginic acid-glucosamine-calcium-collagen peptide complex with a three-component synchronous slow release effect as well as a large-scale preparation method and application of the alginic acid-glucosamine-calcium-collagen peptide complex. The preparation method comprises the following steps: preparing collagen peptide purified by anion exchange chromatography / resin by taking animal connective tissue as a raw material; preparing glucosamine hydrochloride by taking squid cartilage as a raw material, adding a calcium chloride solution, and stirring at constant temperature to complete a first complexation reaction to obtain a glucosamine-calcium complex; then adding a collagen peptide solution purified by anion exchange chromatography / resin, and stirring at a constant temperature to complete a second complex reaction to obtain a glucosamine-calcium-collagen peptide complex; and finally adding a sodium alginate solution, stirring at a constant temperature to complete a third complexation reaction, and desalting through a nanofiltration membrane and spray-drying to obtain the alginic acid-glucosamine-calcium-collagen peptide complex. The complex can realize the synchronous slow-release effect of three components of glucosamine, calcium and collagen peptide for not less than 3 hours, and can prevent high-concentration sodium and chloride ions from hurting a human body.

1. Name of the product in this design: Packaging Box (Glucosamine Hydrochloride Capsules). 2. Intended use of this design: pharmaceutical packaging box. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention relates to a composition with a function of improving bone mineral density, application of the composition and a preparation method of related health-care products or foods, and the composition comprises the following components in parts by weight: 0.5-4.5 parts of D-glucosamine hydrochloride, 0.5-3 parts of calcium carbonate, 0.1-1.5 parts of sodium chondroitin sulfate, 0.5-2.5 parts of American ginseng extract, 0.2-2 parts of salvia miltiorrhiza extract, 0.15-1.5 parts of radix paeoniae alba extract and 0.1-1 part of turmeric extract. The composition is prepared into a medicine, a health care product or a food to increase the bone mineral density. According to the composition, green, natural and high-quality raw materials and auxiliary materials are selected, the composition is prepared from the perspective of traditional Chinese medicine, modern nutriology and modern pharmacology, calcium supplement, articular cartilage protection and inflammation relieving are integrated, the formula plays a comprehensive role in increasing the bone mineral density in different links, and the effect of increasing the bone mineral density under the effect of three pipes is achieved. The composition can be prepared into medicines, health-care products or foods, the preparation process is simple, and the prepared product is green, safe and remarkable in curative effect and has a good market prospect.

The invention discloses a self-cleaning filtering method for water treatment, and belongs to the technical field of fountain water treatment. Comprising pretreatment, filtration and adsorption treatment and disinfection treatment. The pretreatment stage comprises the following steps: centrifugally separating the spring, adding a composite functional agent containing modified polyaspartic acid, modified glucosamine hydrochloride and the like, and filtering through a microfiltration screen; in the filtering adsorption treatment stage, the pretreated effluent is mixed with a modified silicon dioxide-polyepoxysuccinic acid compound self-cleaning agent and then introduced into a PVDF-TiO2 composite modified ultrafiltration membrane assembly, and membrane effluent is treated through an nHAP-activated carbon composite adsorption column; in the disinfection treatment stage, food-grade sodium hypochlorite is added into the deeply-treated water for disinfection, and the disinfected water is treated through an activated carbon adsorption tank to obtain the treated bubbling spring. The problems that a high-turbidity and high-calcium scale composite layer is difficult to remove, a humic acid-calcium complex is difficult to adsorb, and high-drug-resistance bacteria are difficult to disinfect in the karst rainy season can be solved.

The present invention provides a homogenized pitaya polysaccharide, a preparation method and application thereof, and belongs to the technical field of polysaccharide extraction and purification. The homogenized pitaya polysaccharide is a polysaccharide whose monosaccharide composition is mannose, glucosamine hydrochloride, rhamnose, glucuronic acid, galacturonic acid, glucose, galactose and arabinose, with a relative molecular weight of 8.08×104 Da and a corresponding molar ratio of 0.181:0.250:16.544:12.762:3.793:0.739:51.014:14.716. The present invention also provides a preparation method of the homogenized pitaya polysaccharide and its application in the preparation of lipid-lowering and blood sugar-lowering drugs. The homogenized pitaya polysaccharide of the present invention has obvious lipid-lowering and blood sugar-lowering effects. Since it comes from a natural product, it has no toxic side effects and can be used to prepare lipid-lowering and blood sugar-lowering drugs.

This invention relates to the field of glucose preparation technology and relates to an unsaturated glucosamine with retained amino groups, its preparation method, and its applications. It solves the problems of low polymer drug loading, severe drug burst release, and poor biocompatibility caused by the blocking of amino groups in existing polymerizable monomers of glucosamine, as well as the cumbersome, low-yield, and poor-purity problems of existing methods for retaining amino groups. The preparation method includes: adding acetyl chloride to 3-buten-1-ol, stirring evenly at 0-5°C, then adding D-glucosamine hydrochloride in batches, heating to 60-80°C, and reacting for 2-4 hours. After the reaction is complete, post-treatment is performed to obtain an intermediate compound; dissolving the intermediate compound in deionized water, adding barium hydroxide hydrate, heating to 90-110°C, and stirring for 12-20 hours, after which post-treatment is performed to obtain unsaturated glucosamine with retained free amino groups. This invention can be applied to the preparation of drug carriers and has broad application prospects in the biomedical field.

The invention provides a method for determining the content of sodium hyaluronate. The method comprises the following steps: (1) preparing D-glucosamine hydrochloride standard curve solutions with series concentrations; (2) preparing a sample solution; (3) respectively taking the standard curve solution and the sample solution, adding a PMP-methanol solution and a sodium hydroxide solution, reacting at a constant temperature, extracting, separating and filtering to respectively obtain a derivatization standard solution and a derivatization sample solution; (4) performing gradient elution on the derivatization solution to obtain data of a corresponding relation between the concentration and the peak area of the derivatization standard solution and data of the peak area of a target peak of the glucosamine-PMP derivative in the derivatization sample solution; and (5) calculating the content of sodium hyaluronate according to the standard curve. PMP derivatization enables glucosamine to be converted into a strong absorption derivative, and gradient elution realizes efficient separation. And the effects of small impurity interference in the complex matrix and high accuracy of low-content sample determination are realized.

The invention belongs to the technical field of animal foods, and relates to a nutritional food for improving joint health of pets and a preparation method thereof. The nutritional food comprises the following raw materials: sweet potato powder, chicken powder, enzymolysis chicken, chicken oil, grains, beef powder, starch, fruit and vegetable powder, chicken liver powder, whole goat milk powder, fish oil, linseed oil, yolk powder, vitamin E, sodium hyaluronate, bovine bone collagen peptide, glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone, a vitamin mineral premix and a Chinese herbal medicine premix. The nutritional food for improving joint health of pets provided by the invention is rich in nutrition, good in palatability and simple in production process, does not lose nutrition of the raw materials, and promotes and improves digestibility of the nutritional food. Animal experiments show that the nutritional food for improving the joint health of the pets has the advantages that the Lequesne score of canine arthritis is reduced, the levels of IL-1beta and TNF-alpha in canine serum are reduced, the level of CTXII in the canine serum is reduced, and the canine osteoarthritis is effectively prevented and treated.

The invention relates to the technical field of analysis, in particular to an analysis method of glucosamine hydrochloride. The invention provides an analysis method of glucosamine hydrochloride, which can accurately, sensitively and quickly detect the content of glucosamine hydrochloride in a product (such as oral liquid), and can be used for realizing quality control on the product containing glucosamine hydrochloride.

A pulverizer output hopper is arranged at the lower end of a pulverizer main body, a feeding port is formed in the upper end of the pulverizer main body, a conveying pipe is arranged in the feeding port, a feeding port suction hood is arranged on the right side of the feeding port, and a discharging port suction hood is arranged on the right side of the feeding port. According to the glucosamine hydrochloride pulverizer convenient for dust collection, the situation that in the prior art, in the actual use process, wet dust removal is still adopted, removed medicine powder needs to be dried and ground again to be reused, the process is complex, and the efficiency is low is improved, and in the equipment working process, the dust removal efficiency is greatly improved. During grinding, dust floats out from the feeding port, at the moment, the air curtain arranged at the feeding port can block powder from drifting away and blow the powder into the air suction hood of the feeding port, then the powder enters the powder separator to be subjected to gas-solid separation, the separated powder can be directly recycled to the output hopper, waste is avoided, the powder does not need to make contact with water, and the use cost is low.

The invention provides an edible and medicinal composite nutritional factor composition with a function of improving bone mineral density. Through optimization of nutrition composition and proportion and systematic research on verification, the formula which takes eucommia ulmoides and herba epimedii as a conditioning basis and is compounded with calcium carbonate, D-glucosamine hydrochloride, sodium chondroitin sulfate and collagen and has the function of improving bone mineral density is constructed. The whole plant components synergistically play a role in tonifying bones, and nutritional factors such as calcium, collagen and glucosamine complement each other in efficacy to provide nutritional support for bones and joints. Meanwhile, by combining the process design of nano embedding and the like, the preparation method for promoting the absorption of the composition is realized, and the calcium absorption rate and the bone calcium content can be improved. Animal safety and function experiments prove that the health-care food is a safe and non-toxic product capable of improving bone mineral density, and is used for strengthening waist and knees, strengthening muscles and bones, supplementing calcium, improving osteoporosis, protecting joints, relieving joint stiffness and pain and the like.