16 results about "Glucosamine Hydrochloride" patented technology

The utility model relates to the technical field of glucosamine hydrochloride, in particular to glucosamine hydrochloride post-processing equipment which comprises a coating barrel with an opening in the top, the coating barrel is connected with the lower end of a powder storage barrel, a plurality of discharging holes are formed in the bottom of the powder storage barrel, a baffle is arranged below the powder storage barrel, and a plurality of discharging holes are formed in the bottom of the powder storage barrel. A through hole matched with the discharging hole is formed in the baffle, the middle of the baffle is connected to the middle of the circumferential side face of a rotating shaft in a sleeving mode, a plurality of stirring rods are installed at the lower end of the circumferential side face of the rotating shaft, a scraper is installed on the circumferential side face of the rotating shaft on one side of the stirring rods, and the upper end of the rotating shaft penetrates through the top of the containing plate to be connected with the driving end of a rotating motor; due to the fact that the discharging holes are evenly distributed in the bottom of the powder storage barrel, powder can be evenly added, and due to the fact that the scraping plate is arranged, the scraping plate can be driven to rotate under driving of the rotating motor, scraping of the inner wall of the coating barrel is achieved, and the situation that in the coating process, the powder is prone to adhering to the inner wall of the coating barrel, and follow-up cleaning wastes time and labor is avoided.

The invention provides a glucosamine hydrochloride capsule and a preparation method thereof, the capsule content comprises the following components in parts by weight: 240 parts of glucosamine hydrochloride, 50-60 parts of starch and 2-7 parts of hydroxypropyl cellulose; the glucosamine hydrochloride capsule prepared by controlling the particle sizes of the glucosamine hydrochloride and the starch within a specific range and using a specific adhesive is high in dissolution rate (the dissolution rate in four dissolution media for 45 minutes is not lower than 85%), and the dissolution rate is stable after the glucosamine hydrochloride capsule is placed for 24 months for a long time.

The application discloses a multi-component synovitis treatment composition based on repairing cartilage tissue and application thereof, and relates to the technical field of biological medicine, and the composition is composed of glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone and graded molecular weight sodium hyaluronate; the application precisely compounding the graded molecular weight sodium hyaluronate with the glucosamine hydrochloride, the chondroitin sulfate and the dimethyl sulfone according to weight parts, constructs a gradient slow-release and target delivery system of synovitis lesions, specifically inhibits the activity of hyaluronidase in the inflammatory joint cavity by using the dimethyl sulfone, greatly reduces the degradation of the sodium hyaluronate, prolongs the residence time of the active ingredients at the lesion site, realizes immediate analgesia and relieves joint stiffness by quickly forming a lubricating protective film by the high molecular weight sodium hyaluronate, the medium and low molecular weight sodium hyaluronate penetrates the synovial membrane barrier and carries the cartilage repair components to enrich in the cartilage defect area, and the synergistic effect of the components is realized.

The application discloses a kind of glucosamine hydrochloride crude product purification refining process, comprising the following steps: (1) glucosamine hydrochloride crude product is dissolved in water, then add the composite precipitant consisting of sodium chloride and sodium hydroxide, after standing, solid-liquid separation, collected separated liquid phase.(2) after the liquid phase is concentrated, add sodium percarbonate and mix evenly and stand still.After completion, pass in carbon dioxide to convert sodium hydroxide in concentrated solution into sodium carbonate, then continue to add calcium nitrate under stirring condition to make carbonate ion in system complete precipitation, i.e., the liquid to be extracted is obtained.(3) after the liquid to be extracted is cooled, add ethanol for alcohol precipitation, after completion, carry out solid-liquid separation, and the obtained solid product and separated liquid are collected respectively.The solid product is washed with ethanol and dried, and glucosamine hydrochloride finished product is obtained.The above process not only can improve the purity of glucosamine hydrochloride, but also can improve the yield of glucosamine hydrochloride in alcohol precipitation process, thereby reducing waste.

This invention relates to the field of fabric technology, specifically to a highly flexible suit coat fabric and its textile process. The fabric comprises a 2 / 2 twill cotton greige fabric and a flexible finishing layer fixed to the surface of the cotton fibers. The flexible finishing layer is formed by sequentially padding and pre-drying the greige fabric, which has undergone limited pretreatment with cellulase, with a first surface finishing solution of aldehyde-modified amylopectin / D-glucosamine hydrochloride, followed by coupling with a 3-aminopropyltriethoxysilane surface coupling solution, and a final finishing with D-glucosamine hydrochloride. The weight-average molecular weight of the aldehyde-modified amylopectin is 2.50 × 10⁻⁶. 5 -4.50×10 5 The degree of aldehyde substitution is 3.0%–7.0%. This invention enables the fabric to possess softness, washability and softness retention, tensile strength retention, breathability and moisture diffusion properties without the addition of formaldehyde resin finishing agent, making it suitable for clothing fabrics such as suits and overcoats.

The invention relates to a composition with a function of improving bone mineral density, application of the composition and a preparation method of related health-care products or foods, and the composition comprises the following components in parts by weight: 0.5-4.5 parts of D-glucosamine hydrochloride, 0.5-3 parts of calcium carbonate, 0.1-1.5 parts of sodium chondroitin sulfate, 0.5-2.5 parts of American ginseng extract, 0.2-2 parts of salvia miltiorrhiza extract, 0.15-1.5 parts of radix paeoniae alba extract and 0.1-1 part of turmeric extract. The composition is prepared into a medicine, a health care product or a food to increase the bone mineral density. According to the composition, green, natural and high-quality raw materials and auxiliary materials are selected, the composition is prepared from the perspective of traditional Chinese medicine, modern nutriology and modern pharmacology, calcium supplement, articular cartilage protection and inflammation relieving are integrated, the formula plays a comprehensive role in increasing the bone mineral density in different links, and the effect of increasing the bone mineral density under the effect of three pipes is achieved. The composition can be prepared into medicines, health-care products or foods, the preparation process is simple, and the prepared product is green, safe and remarkable in curative effect and has a good market prospect.

This invention relates to the field of glucose preparation technology and relates to an unsaturated glucosamine with retained amino groups, its preparation method, and its applications. It solves the problems of low polymer drug loading, severe drug burst release, and poor biocompatibility caused by the blocking of amino groups in existing polymerizable monomers of glucosamine, as well as the cumbersome, low-yield, and poor-purity problems of existing methods for retaining amino groups. The preparation method includes: adding acetyl chloride to 3-buten-1-ol, stirring evenly at 0-5°C, then adding D-glucosamine hydrochloride in batches, heating to 60-80°C, and reacting for 2-4 hours. After the reaction is complete, post-treatment is performed to obtain an intermediate compound; dissolving the intermediate compound in deionized water, adding barium hydroxide hydrate, heating to 90-110°C, and stirring for 12-20 hours, after which post-treatment is performed to obtain unsaturated glucosamine with retained free amino groups. This invention can be applied to the preparation of drug carriers and has broad application prospects in the biomedical field.

The invention provides an edible and medicinal composite nutritional factor composition with a function of improving bone mineral density. Through optimization of nutrition composition and proportion and systematic research on verification, the formula which takes eucommia ulmoides and herba epimedii as a conditioning basis and is compounded with calcium carbonate, D-glucosamine hydrochloride, sodium chondroitin sulfate and collagen and has the function of improving bone mineral density is constructed. The whole plant components synergistically play a role in tonifying bones, and nutritional factors such as calcium, collagen and glucosamine complement each other in efficacy to provide nutritional support for bones and joints. Meanwhile, by combining the process design of nano embedding and the like, the preparation method for promoting the absorption of the composition is realized, and the calcium absorption rate and the bone calcium content can be improved. Animal safety and function experiments prove that the health-care food is a safe and non-toxic product capable of improving bone mineral density, and is used for strengthening waist and knees, strengthening muscles and bones, supplementing calcium, improving osteoporosis, protecting joints, relieving joint stiffness and pain and the like.

The invention relates to an external transdermal enhanced gel composition for nursing joints of dogs and cats and a preparation method of the external transdermal enhanced gel composition, and belongs to the technical field of pet health care and health care. The gel composition comprises: a) 1.0-2.5% of a gel matrix, wherein the gel matrix comprises xanthan gum and gellan gum in a weight ratio of (3-1): 1; b) 6-20% of an active care component, wherein the active care component comprises a frankincense extract, glucosamine hydrochloride, low molecular weight chondroitin sulfate, menthol and methylsulfonylmethane; c) 7-20% of a transdermal enhancing component, the transdermal enhancing component comprises azone, propylene glycol and curcumin-loaded anion liposome dispersion liquid, the weight ratio of azone to propylene glycol is 1: (1.5-3), and the solid weight of the anion liposome accounts for 0.5-2.0% of the total weight of the gel composition. The composition has excellent transdermal performance, exact anti-inflammatory and analgesic effects and excellent pet nursing compliance.

The application discloses a composition for preventing and treating osteoporosis and a preparation method and application thereof, and belongs to the field of biopharmacy. The method comprises the following steps: uniformly spraying a sodium bicarbonate aqueous solution on eucommia ulmoides oliver powder, sealing and infiltrating, and then slowly frying, spraying vinegar in the frying process, turning off the fire after the silk is broken, and then spreading and airing to reduce the temperature, and then extracting by ethanol reflux to obtain eucommia ulmoides oliver extract; sterilizing the drynaria rhizome powder at high temperature, adding lactobacillus plantarum after cooling, sealing and fermenting, and then extracting by ethanol reflux to obtain drynaria rhizome extract; and uniformly mixing the extracted eucommia ulmoides oliver extract and the drynaria rhizome extract, D-glucosamine hydrochloride, sodium chondroitin sulfate, epimedium extract and oyster powder to obtain the composition for preventing and treating osteoporosis. The eucommia ulmoides oliver is prepared by the method of sodium bicarbonate salt stir-frying and vinegar stir-frying, and the drynaria rhizome is treated by fermentation, so that the warm and dry properties of the original composition can be neutralized, the side effects of heatiness such as constipation, dry mouth, gum swelling and pain or sore throat can be reduced, and the safety and tolerance of the composition are improved.

The present invention discloses a multi-component synovitis therapeutic composition based on cartilage tissue repair and a use thereof, relating to the technical field of biomedicine. The composition comprises glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone, and graded molecular weight sodium hyaluronate. By compounding these components in precise parts by weight, the present invention constructs a gradient sustained-release and targeted delivery system for synovitis lesions. Dimethyl sulfone specifically inhibits hyaluronidase activity in the inflamed joint cavity, significantly reducing sodium hyaluronate degradation and prolonging the retention time of each active ingredient at the lesion site. High molecular weight sodium hyaluronate rapidly forms a lubricating protective film to achieve immediate analgesia and relieve ankylosis, while medium- and low-molecular-weight sodium hyaluronate penetrates the synovial barrier and carries cartilage repair components to the cartilage defect area, thereby achieving synergistic enhancement and comprehensively improving synovitis treatment efficacy.

This invention discloses a composite deepening silicone oil and its preparation method, belonging to the field of silicone oil technology. The composite deepening silicone oil is made from the following raw materials in the indicated weight percentages: 40-50% amino silicone oil, 10-20% polyether-modified silicone oil, 1-2% nano-titanium dioxide, 0.5-1% γ-piperazinylpropylmethyldimethoxysilane, 2-4% emulsifier, 3-7% organic solvent, 1-2% glucosamine hydrochloride, 0.5-3% xylitol, with the balance being deionized water. The composite deepening silicone oil of this invention provides a deepening effect while ensuring its durability and stability, allowing fabrics to maintain a soft and smooth feel while deepening their texture, avoiding the stiffness problem caused by traditional silicone oil treatments.

This invention belongs to the field of inorganic material crystal preparation technology, specifically relating to a method for preparing calcium sulfate dihydrate whiskers using carbide slag. The method includes the following steps: dissolving an organic acid salt in water to prepare a solution; adding carbide slag powder and reacting, followed by solid-liquid separation to obtain a calcium ion filtrate; adding dilute sulfuric acid dropwise to the filtrate under constant temperature stirring to generate a whisker-containing slurry; aging the slurry at a constant temperature, followed by filtration, washing, and drying to obtain the calcium sulfate dihydrate whisker product. The organic acid salt is selected from betaine hydrochloride, glucosamine hydrochloride, or lysine hydrochloride, which acts as a "calcium ion carrier" and "morphology regulator" in the reaction, and can achieve in-situ regeneration and recycling. By optimizing key parameters such as reaction temperature, reaction time, and aging time, this invention can stably prepare calcium sulfate dihydrate whiskers with an aspect ratio of 75:1. This method uses industrial waste carbide slag as the main raw material, achieving high-value utilization of waste, and the process is green and recyclable.

The invention discloses a porous carbon material and a template-free preparation method thereof. The specific surface area of the porous carbon material is not less than 500 m < 2 > / g, and the total content of pyrrole nitrogen and pyridine nitrogen accounts for not less than 85% of the total nitrogen element; the method comprises the following steps: dissolving carboxylated chitosan and glucosamine hydrochloride in water to obtain a mixed solution; carrying out hydrothermal reaction on the mixed solution to form a hydrogel precursor with a gap structure; and drying the precursor, and carrying out carbonization treatment in an inert atmosphere to finally obtain the porous carbon material rich in pyrrole nitrogen and pyridine nitrogen. The method does not need to use any template agent and etching agent, and is simple in process, low in cost, green, environment-friendly and easy for large-scale production. The porous carbon material prepared by the invention has high specific surface area and high content of electrochemical active nitrogen species, and the lithium ion battery silicon-carbon negative electrode material prepared by taking the porous carbon material as a substrate shows excellent electrochemical performance.

The application belongs to the technical field of lithium ion batteries, and specifically discloses a kind of lithium ion battery nano composite negative electrode material and its preparation method, with glucosamine hydrochloride as amorphous carbon source, GO and SnCl2 as raw material, SnO2@C-NH2 / rGO nano composite material is prepared by one-step hydrothermal method, the introduction of amino functional group can further enhance the interaction between SnO2 particles and amorphous carbon layer, make the growth of SnO2 grain be further inhibited, and help to firmly anchor SnO2 nanoparticles on the surface of rGO sheet layer;At the same time, the nitrogen doping of carbon structure not only improves the conductivity of the whole material, but also provides more active sites for Li + deintercalation;Therefore, the capacity of SnO2@C-NH2 / rGO prepared by the application is 810mAh / g after 75 cycles, which shows that the lithium ion battery nano composite negative electrode material prepared by the application has good electrochemical cycle performance.

This application relates to the field of pet bone repair, specifically to a nutritional supplement for pet bone repair and regeneration and its preparation method. The supplement comprises the following components in parts by weight: 5 parts non-denatured type II collagen, 10-15 parts hyaluronic acid, 20-25 parts chondroitin sulfate, 6-7 parts hydrogen phosphate, 3-4 parts vitamin D3, 15-20 parts glucosamine hydrochloride, 0.5-1 part manganese glycine, 0.5-1 part magnesium aspartate, and 5-6 parts ascorbate. This application utilizes non-denatured type II collagen to activate regulatory T cells, reducing the release of inflammatory factors and thus alleviating joint pain and swelling; simultaneously, Treg cells secrete growth factors to stimulate chondrocyte regeneration and matrix synthesis, repairing damaged cartilage structure; the other components, combined with non-denatured type II collagen, stimulate chondrocytes to synthesize proteoglycans and collagen fibers, enhancing joint lubrication and cushioning function.