493 results about "Hesperidin" patented technology

Disclosed is a composition comprising at least two of the following ingredients: Magnolia extract, honokiol, humulus lupulus extract, hesperidin methyl chalcone, gotu kola, dipeptide valyl-tryptophane, palmitoyl tetrapeptide-3, corylus avellana bud extract, centella asiatica extract, cucumis sativa extract, morus alba extract, hibiscus sabdariffa flower extract, vitis vinifera extract, ascorbyl glucoside, citrus medica limonum extract, avena sativa kernel extract, hydrolyzed soy protein, aniseed myrtle extract, tasmania lanceolata leaf extract, artemisia abrotanum extract, or citrus grandis fruit extract or any combination thereof. Also disclosed are methods of treating skin conditions by topically applying the composition to skin.

The invention relates to novel cosmetic or dermopharmaceutical compositions for topical use which are used to prevent the symptoms of cutaneous slackening and, more specifically, to treat the visible signs of ageing and fatigue, such as bags and circles under the eyes. The inventive compositions comprise, in a cosmetically-acceptable medium, a combination of at least two, and preferably three, components selected from: a) hesperidin or the derivatives thereof; b) A.C.E. enzyme inhibitor dipeptides; and c) oligopeptides R₂-(AA)_n-Pro-Arg-OH, wherin (AA)_n is a peptide chain, (AA) is any amino acid or any derivative of any amino acid, n is included between 1 and 3, and R₂═H or an alkyl chain having a carbon length of between C₂ and C₂₂.

The invention relates to a method for preparing naringin or hesperidin, which comprises the following operating steps of: 1) drying and crushing fruits, fruit peels and fruit residues containing the naringin or the hesperidin, and respectively filling the crushed materials into an extraction kettle of a pressure solvent extraction device; 2) selecting an extraction solvent, setting an extraction pressure, an extraction temperature, an extraction static time and an extraction frequency, extracting with the pressure solvent extraction device, and collecting the extract liquor; and 3) concentrating the extract liquor in vacuum, centrifugating the extract liquor or filtering the extract liquor to remove insoluble substances, adjusting pH of the clear liquid, cooling the clear liquid to crystallize or precipitate, recrystallizing the coarse crystals, drying the coarse crystals, or re-dissolving the precipitate for re-precipitation, and obtaining a pure product of the naringin or the hesperidin. Compared with the conventional solvent extraction method, ultrasonic-assisted extraction method and microwave-assisted extraction method, the preparation method has the advantages of high speed, capability of repeatedly extracting, safety, high efficiency, and simple post treatment such as concentration and purification.

The invention relates to a process for preparing hesperidin, which has simple and convenient operation and less pollution and equipment investment. The process comprises the following steps: adding 3to 10 times of 10-80 percent of alcohol into dried orange peel coarse powder to heat, back flow and extract for one to three times for 2 hours each time; combining extracting liquid and filtering; decompressing filter liquid to recover the alcohol till completion; filtering when the filter liquid is hot, refrigerating for 12 hours and filtering; washing filter residues by water, drying at low temperature and adding 50 percent of alkaline alcohol to dissolve; filtering and adding acid into the filter liquid to neutralize; precipitating sediments and collecting the sediments; recrystallizing thealcohol, washing and drying to obtain the hesperidin. The process for preparing hesperidin has high product purity and is easy to realize industrialization amplification.

The invention relates to an action of ferulic acid on enhancing the drug effect of some medicaments and a purpose thereof, wherein the medicaments mainly comprise alkaloid medicaments including matrine, kushenin, sophocarpine, hyoscyamine, narceine, hanfangchin A, jamaicin, morphine, codeine, evodiamine, strychnine, catharanthine, vincristine, taxol, verticine, peimine, peiminine, ephedrine, pseudoephedrine, wilfordine, triptolide, tripdiolide and the like, and flavonoid medicaments including puerarin, ginsenoside, ginsengenin, mangiferin, scutelloside, alkannin, meletin, rutin, hesperidin, daidzin, soybean isoflavone, daidzein, carthamin, catechin and the like. The ferulic acid and the medicaments can form a compound or a medicament compound, or the ferulic acid and the medicaments can generate a chemical reaction (including salification, esterification, amidation, ketonization, etherification and the like), and/or the ferulic acid and the medicaments can generate a synergistic effect and an additive effect.

The present invention relates to pharmaceutical compositions comprising dextromethorphan or a physiologically acceptable salt thereof, quercetin, resveratrol, and hesperidin. The invention further relates to nutraceutical or dietary supplement composition comprising a physiologically acceptable salt of magnesium, quercetin, resveratrol, and hesperidin. Further provided are methods for treating respiratory disease in a human subject by substantially eliminating phlegm from the lung through administering to the subject effective amounts of compositions of the invention.

The invention discloses a method for extracting hesperidin from tangerine peel. The method comprises: mixing tangerine peel with a solid-phase alkali reagent, wherein the tangerine peel is tangerine peel powder which is ground to have a powder particle size analysis result D90 between 10 and 200 mu m; adding water, stirring, centrifuging and taking supernatant; adding acid to regulate pH between 2.0 and 6.0; standing and then filtering the obtained product; drying a filter cake; and obtaining hesperidin. The solid-phase alkali reagent is one or arbitrary mixture of more than two of sodium hydroxide, aluminum hydroxide, calcium hydroxide, potassium hydroxide, sodium bicarbonate, potassium bicarbonate, sodium carbonate, potassium carbonate, calcium carbonate, sodium silicate, disodium hydrogen phosphate or dipotassium hydrogen phosphate. By adopting a mechanochemical technique to extract and separate the hesperidin, the method has the advantages of high extraction rate, high product purity, simple process, environment-friendly property, low cost and short production cycle, and is an extraction-separation route with broad industrialization prospects.

The invention belongs to the technical field of natural product extraction from oranges, and specifically relates to a method for continuously extracting natural activated products such as synephrine, hesperidin and limonin from physiological orange drops. The method comprises the following steps: using orange drops which are dried and crushed into 20-100 meshes as raw materials, adding 50-90% ethanol according to a weight/volume ratio of (1:10)-(1:50), extracting under reflux at 40-80 DEG C for 1-3 hours, filtering, recovering ethanol from the filtrate, and obtaining a concentrated solution for later use; adding a small number of chloroform crystals into the concentrated solution, adding water for layering, directly heating the water layer to 75 DEG C, filtering, adding 0.1mol/L hydrochloric acid to regulate the pH value to 3-4, and precipitating to obtain a hesperidin crude product; carrying out spin drying on the obtained chloroform layer solution, adding a right number of acetone crystals, and carrying out vacuum drying to obtain a synephrine crude product; and carrying out spin drying on the acetone solution after the crystal filtration, adding dichloromethane for dissolution, filtering, adding isopropanol into the solution according to a volume ratio of 1:2, and crystallizing to obtain a limonin crude product. Qualitative and quantitative analysis are carried out on the three resulting activated products through high-pressure liquid chromatography, and the result shows that the hesperidin has the highest purity (91.41%).

The invention belongs to a preparation method of Chinese medicine dried orange peels. The method has the characteristics of reducing the content of volatile oil and reducing pungentness, warmth and dryness. The method specifically comprises the following steps of: putting dried orange peels in a closed container; adding water which is 1-2 times as heavy as the dried orange peels; stuffily moistening for 1-3h at room temperature; steaming for 20-90 min at a temperature of 70-100 DEG C; taking out; air drying; and cutting into shreds to obtain a steamed product. At present, other areas in China all adopt the process of fine selecting, washing and cutting into shreds for raw use, but the preparation method of the invention adopts the process of steaming after fine selecting and then cutting into shreds for prepared use, which suppresses the pungentness and the dryness of the dried orange peels through reducing the content of the volatile oil and corrects the bias of medicinal materials, and meanwhile, the increase of the content of hesperidin guarantees the quality of the medicinal materials. The preparation method conforms to the characteristics of geographical and climatic environments and symptom medication in south of the Five Ridges in China and provides a new decoction slice variety for the reasonable clinical application of the dried orange peels of the area.

The invention discloses a method for extracting synephrine and hesperidin from citrus aurantium, and relates to a method for producing and processing traditional Chinese medicine. The method comprises the following steps of: step 1, washing and crushing a citrus aurantium raw material into citrus aurantium granules; adding an acid solution for soaking the citrus aurantium granules, then carrying out percolation and extracting extract, concentrating the extract under the reduced pressure to obtain extractum, and drying the extractum under the reduced pressure to obtain synephrine; step 2, adding a weak base solution into the leached citrus aurantium granules which are extracted after being soaked by the acid solution, carrying out decoction and removing impurities, then adding a mixed solvent of sodium hydroxide and calcium chloride into the citrus aurantium granules, and extracting to obtain extract; step 3, adding hydrochloric acid into the extract for neutralization until the pH value is 3-7, standing still and crystallizating; and step 4, collecting crystalline, and drying to obtain the hesperidin. Compared with the prior art, the method can be used for extracting two components without using an organic solvent, so that the production cost is reduced, the production technology is simplified, the synephrine yield is more than 15%, the content of the synephrine is more than 10%, the hesperidin yield reaches more than 27%, and the content of the hesperidin is more than 96%; and therefore, the method is suitable for industrialized mass production.

The invention discloses anti-allergic facial mask fluid for promoting skin regeneration. According to the anti-allergic facial mask fluid, a variety of pure natural plant extracting solutions are in combined use to achieve a certain synergistic effect, immunoregulation and inflammation prevention can be really achieved endogenously, the self-repairing ability of the skin can also be activated, and after the anti-allergic facial mask fluid is used, the skin is comfortable, no irritation can be caused, and erythema can be improved. Relative to the total mass of the facial mask fluid, the anti-allergic facial mask fluid comprises the following components in percentage by mass: 0.1-0.2% of hyaluronic acid, 0.5-1% of tranexamic acid, 0.05-0.1% of methyl hesperidin, 0.01-0.03% of carboxymethyl dextran, 2-3% of a wheat protein hydrolysate, 0.5-0.8% of a common lophatherum herb extracting solution, 1-1.5% of a baikal skullcap root extracting solution, 2.3-3% of a danshen root extracting solution, 0.3-0.5% of a fresh ginger extracting solution, 0.5% of an aloe extracting solution, 2-2.5% of a wild chrysanthemum flower extracting solution, 0.2-0.8% of a largehead atractylodes rhizome extracting solution and 0.2-0.3% of 1,2-hexanediol.

The invention discloses a preparation method for extracting hesperidin from citrus aurantium, comprising the following steps: (1) preparing the raw material, i.e. citrus citrus fine powder, and pouring it into an extraction tank; (2) preparing an alkali solution to soak the material in the tank After the treatment, empty the liquid and turn over the material; (3) configure the alkali solution to heat the tank material; (4) configure the alkali solution to perform the first percolation treatment on the tank material, then drain the liquid and turn over the material; (5) Alkali solution is prepared to carry out the second diafiltration treatment on the material in the tank, and then the liquid is emptied and then turned over; (6) pumping in the extract to extract hesperidin; (7) isolating hesperidin crystallization; (8) treating hesperidin Glycoside crystals were filtered and dried. The invention has the beneficial effects of simple process, low cost and high purity of the extracted hesperidin.

The invention relates to a whitening composition (uniGlow) and an application thereof. The whitening composite comprises phenylbenzimidazole sulfonic acid, hydroxyphenylpropylamide benzoic acid, dipotassium glycyrrhizinate, undecylenoyl phenylalanine, hydrolyzed shellfish protein, beta-arbutin, ellagic acid, sodium ascorbate phosphate, carnosine, nicotinamide, inositol, papain and hesperidin extract. The whitening composition performs targeted inhibition from the melanin forming inducements of UV, inflammatory factors, melanoma and endothelin; in the melanin synthesis process, tyrosinase inhibits the reduction with a melanin intermediate, blocks the melanin transfer pathway, accelerates stratum corneum spalling and accelerates the metabolism; by conditioning, the skin is fine, tight, natural, white and bright.

The invention discloses a method for jointly extracting hesperidin and pectin from citrus peels, relating to a deep processing method for comprehensive utilization of the citrus peels. The method comprises the steps of preprocessing the raw material, namely dry or fresh citrus peels, then preparing a hesperidin product, and finally preparing a pectin product. The method has the characteristics that production equipment is conventional equipment, production conditions are easy for implementation, and the method is convenient to operate and is suitable for industrial production; the products are high in yield and high in purity (the yield of the hesperidin reaches up to 1.85%-2.72%, the purity of the hesperidin reaches up to 91.56%-95.34%, and the yield of the pectin reaches up to 9.35%-15.56%), and the quality of the products meets the requirements of the market. The method can be widely used for producing hesperidin and pectin products, the hesperidin product prepared by the method can be widely used in fields like anti-inflammation, antioxidation, and maintenance of blood vessel normal osmotic pressure, and the pectin product prepared by the method can be widely used in fields like foods and cosmetics.

The invention relates to a high performance liquid chromatography-mass spectrometry (HPLC-MS) quantitative method for measuring 10 components of a fructus evodiae formula granule. The method is characterized in that a HPLC-MS technology is used; acetonitrile is taken as the A phase; acetic acid (0.12%)-ammonium acetate (1 mmol/L) is taken as the B phase; gradient elution with four scale transformations is performed; the flowing speed is 0.8 mL/min; the column temperature is 40 DEG C; in a multiple reaction monitoring (MRM) mode, positive ions and negative ions are monitored at the same time, the ion source is an ESI source, the atomized gas (GS1) is N2, the auxiliary gas (GS2) is N2; nitrogen gas is used during the whole process; the collision gas pressure is medium; the resolutions of Q1 and Q3 are both UNIT; the method can detect 10 components in the fructus evodiae formula granule, namely chlorogenic acid, caffeic acid, rutin, hyperin, hesperidin, dehydroevodiamine, limonin, evodiamine, rutaecarpin, and evocarpine; 10 components can be all detected in 22 minutes, and the method is rapid and accurate and is not disturbed.

Antimicrobial and contraceptive compositions and methods which prevent and/or reduce the risk of transmission of sexually transmitted diseases through sexual activity as well as prevent and/or reduce the risk of pregnancy are provided. The compositions contain (1) a matrix-forming agent, (2) a bio-adhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water; wherein the composition is suitable for application within the vagina; wherein the compositions form a semisolid matrix on contact with ejaculate (thereby trapping ejaculated microbes and spermatozoa); wherein the composition causes hardening of cervical mucus (thereby decreasing the probability of sperm entry); wherein the composition forms a bio-adhesive layer over vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces); wherein the composition maintains an acidic vaginal pH of less than about 5 in the presence of semen ejaculated from the male; and wherein the composition does not significantly impair the natural microbiological balance within the vagina. The antimicrobial and contraceptive compositions may also contain additional antimicrobial and/or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H2SO4-modified mandelic acids, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, cyclopiroxolamine, and the like).

The invention relates to a method for extracting hesperidin and naringin by microwave-assisted extraction (MAE), which belongs to the field of analytical chemistry. The method includes quantitatively weighing sample, extracting hesperidin and naringin from the sample in mixed solvent of water and organic solvent in a microwave-assisted extraction device by selecting microwave power and extraction time through MAE, centrifuging, collecting the supernatant, diluting, and analyzing and measuring the content of hesperidin and naringin by HPLC. The method is simple and rapid, and has less sample usage amount, good repeatability, and high recovery rate. The method in combination with the HPLC can be used for accurately measuring the content of hesperidin and naringin in fruit juice, fresh fruit and Chinese traditional medicine, and evaluating quality thereof.

The invention discloses a production process of hesperidin, and in particular discloses a process for extracting the hesperidin from an immature bitter orange. The production process comprises the steps of (1) grinding the immature bitter orange, and adding a mixed solvent of methyl alcohol and alkali for cyclic soaking, extraction and filtration to obtain immature bitter orange residues; (2) washing the immature bitter orange residues with the mixed solvent of the methyl alcohol and the alkali, performing filtration to obtain filter liquid (A), and performing refined filtration on the obtained filter liquid (A) to obtain filter liquid (B); (3) adding acid into the filter liquid (B) to adjust the pH value to 5-6, and performing standing and crystallization; (4) collecting crystals, and performing washing and drying to obtain the hesperidin. The production process is simple, the extracted hesperidin is high in purity, other effective components can be also extracted, the emission of waste water is low, and the cost is low.

A method useful for inhibiting moisture loss from skin comprises the step of administering a composition to a subject's skin. The composition comprises a first humectant and a second humectant different from the first humectant. The humectants are useful for increasing moisture content of the subject's skin, specifically the subject's epidermis. The first humectant may comprise a conventional humectant, e.g. glycerol. The second humectant generally comprises certain types of honey. The honey is capable of inhibiting moisture loss from the subject's epidermis and/or moisture loss from the first humectant when the subject is exposed to dry air conditions, e.g. wintertime air having a relative humidity of about 50% or less. Specifically, the second humectant is useful for mitigating adverse effects of the first humectant under certain conditions. Examples of suitable honeys generally include those comprising the flavanone hesperidin, such as orange blossom honey, buckwheat (blossom) honey, or a combination thereof.

The invention relates to a process technology for extracting hesperidin and synephrine from immature bitter oranges. The process technology comprises the following steps of: degreasing the dried immature bitter oranges through petroleum ether and carrying out high-oxidation catalyst by utilizing a diluted alkali solution; filtering and concentrating to be dry; dissolving by utilizing acid water; and adsorbing by resin, eluting by steps, and concentrating and crystallizing to prepare pure products of the hesperidin and the synephrine. The method is simple in operation, greatly improves the yield of the hesperidin and the synephrine, greatly reduces the production cost of the hesperidin and the synephrin, simplifies a production process, and can obtain a lot of oil substances. The immature bitter oranges are used as extraction raw materials so that the utilization efficiency of the immature bitter oranges is greatly improved and the additional value of the immature bitter oranges is improved.

The invention discloses a fragrant microcapsule for composite cigarettes.A nucleus of the microcapsule is prepared from novel methyl hesperidin dihydro chalcone, rhodinol and rhodinol-beta-D-glucopyranoside.A shell of the microcapsule is prepared from chitosan.The invention further discloses a preparation method of the fragrant microcapsule for composite cigarettes and application for increasing fragrance of cigarettes.The fragrant microcapsule for composite cigarettes can keep cigarette fragrance stability, durability and uniformity consistency of fragrance release along with time.

The invention relates to a method for preparing a rod-like imprinted polymer capable of efficiently separating naringin in a water phase. The rod-like imprinted polymer which is an adsorption material having specific recognition capability for naringin organic molecular medicaments with =O and -OH groups can be prepared by an emulsion polymerization method, with the naringin, hesperidin, the naringin or dihydrochalcone as an imprinting molecules, cyclodextrin as a functive and hexamethylene diisocyanate as a cross-linking agent. The prepared rod-like imprinted cyclodextrin polymer has larger specific area and pore volume, benefits the contact of a substrate with a combined locus and improves the capacity. The rod-like molecular imprinted polymer (RMIP) has high affinity and selectivity to the naringin (NG). When the concentration of the NG is 0.02mg/ml, the imprinted molecule alpha reaches 1.53.

A Chinese medicine for treating anorexia of baby is prepared from 12 Chinese-medicinal materials including tuckahoe, tangerine peel, haw, rhubarb, etc through decocting, filtering, concentrating, mixing, etc. Its quality control method including thin-layer chromatography and high-effect liquid-phase chromatography is also disclosed.

The invention relates to the technical field of plant separation and extraction, and in particularly discloses a method of combined extraction of essential oil, pectin, hesperidin, synephrine and limonin from citrus. The method comprises the following steps: inactivating the citrus, buffing and performing enzymolysis to obtain essential oil, a water phase and skin residues; separating the water phase through strong acidic cation-exchange resin to collect effusive liquid, and eluting to obtain synephrine; separating the effusive liquid using ultra-filtration method to obtain pectin and liquid passing through the ultra-filtration film; refluxing and extracting the liquid passing through the ultra-filtration film using ethanol to obtain supernatant and filter residue; crystallizing, and freeze-drying the filter residues to obtain aurantiamarin; separating the supernatant using macroporous resin, and eluting using ethanol to obtain limonin. The method is used for processing fresh citrus to co-produce the citrus pericarp essential oil, pectin, hesperidin, synephrine and limonin; the utilization rate of the resource is improved, the environment pollution is reduced, and the economic and social benefits are notable.

The invention belongs to the technical field of medicine, and relates to a method for preparing flavonoids and total flavonoids in Linaria vulgaris and application thereof. The flavonoids and the total flavonoids come from flavonoid compounds in the Linaria vulgaris (including flavonoid compounds such as pectolinarin, aglycon, acetyl pectolinarin, acetyl linarin, acetyl linarin, hesperidin, robinin, hispidulin, luteolin, vanilla lignin, chrysin and the like). Dried whole herbs of the Linaria vulgaris are subjected to reflux extraction by water or alcohol, then a macroporous resin is used to send to a column, alcohols with different concentrations are used for elution, eluents are collected, then different elution flow ingredients pass through a silica gel chromatographic column, a polyamide chromatographic column, a gel chromatographic column and the like, to obtain various compositions, and the content of an obtained total flavonoid substance is more than 60 percent. The flavonoid compounds can be used for preparing medicines for treating angiocardiopathy, cough, and asthma. An extraction method of the invention is simple, practical and cheap, and is suitable for industrialized production.